{"reactions": [{"subsystem": "Transport Inner Membrane", "name": "1,2 diacylglycerol transport via flipping (periplasm to cytoplasm, n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["12DGR120tipp"]}, "metabolites": {"12dgr120_p": -1.0, "12dgr120_c": 1.0}, "id": "12DGR120tipp", "gene_reaction_rule": ""}, {"subsystem": "Transport Inner Membrane", "name": "1,2 diacylglycerol transport via flipping (periplasm to cytoplasm, n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["12DGR140tipp"]}, "metabolites": {"12dgr140_c": 1.0, "12dgr140_p": -1.0}, "id": "12DGR140tipp", "gene_reaction_rule": ""}, {"subsystem": "Transport Inner Membrane", "name": "1,2 diacylglycerol transport via flipping (periplasm to cytoplasm, n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["12DGR141tipp"]}, "metabolites": {"12dgr141_c": 1.0, "12dgr141_p": -1.0}, "id": "12DGR141tipp", "gene_reaction_rule": ""}, 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"2-acyl-glycerophospho-glycerol acyltransferase (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPGAT161"]}, "metabolites": {"atp_c": -1.0, "2agpg161_c": -1.0, "ppi_c": 1.0, "hdcea_c": -1.0, "pg161_c": 1.0, "amp_c": 1.0}, "id": "2AGPGAT161", "gene_reaction_rule": "STM3010"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-glycerol acyltransferase (n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPGAT180"]}, "metabolites": {"pg180_c": 1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "ocdca_c": -1.0, "2agpg180_c": -1.0}, "id": "2AGPGAT180", "gene_reaction_rule": "STM3010"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-glycerol acyltransferase (n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPGAT181"]}, "metabolites": {"ocdcea_c": -1.0, "atp_c": -1.0, "2agpg181_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, 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"3OAS180", "gene_reaction_rule": "STM1197 or STM2378"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "3-oxoacyl-[acyl-carrier-protein] synthase (n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3OAS181"]}, "metabolites": {"3ocvac11eACP_c": 1.0, "ACP_c": 1.0, "malACP_c": -1.0, "h_c": -1.0, "co2_c": 1.0, "hdeACP_c": -1.0}, "id": "3OAS181", "gene_reaction_rule": "STM1197"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "3-oxoacyl-[acyl-carrier-protein] synthase (n-C6:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3OAS60"]}, "metabolites": {"3ohexACP_c": 1.0, "butACP_c": -1.0, "ACP_c": 1.0, "malACP_c": -1.0, "h_c": -1.0, "co2_c": 1.0}, "id": "3OAS60", "gene_reaction_rule": "STM2378 or STM1197"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "3-oxoacyl-[acyl-carrier-protein] synthase (n-C8:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3OAS80"]}, "metabolites": {"co2_c": 1.0, "3ooctACP_c": 1.0, "ACP_c": 1.0, "malACP_c": -1.0, "h_c": -1.0, "hexACP_c": -1.0}, "id": "3OAS80", "gene_reaction_rule": "STM2378 or STM1197"}, {"subsystem": "Murein Recycling", "name": "Tripeptide (LalaDgluMdap) transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3PEPTabcpp"]}, "metabolites": {"h2o_c": -1.0, "LalaDgluMdap_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "LalaDgluMdap_p": -1.0}, "id": "3PEPTabcpp", "gene_reaction_rule": "STM1679 and STM1745 and STM1744 and STM1743 and STM1742"}, {"subsystem": "Transport Outer Membrane Porin", "name": "LalaDgluMdap (tripeptide) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["3PEPTtex"]}, "metabolites": {"LalaDgluMdap_e": -1.0, "LalaDgluMdap_p": 1.0}, "id": "3PEPTtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "3UMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["3UMPtex"]}, "metabolites": {"3ump_e": -1.0, "3ump_p": 1.0}, "id": "3UMPtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "4-hydroxyphenylacetaldehyde transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["4HOXPACDtex"]}, "metabolites": {"4hoxpacd_p": 1.0, "4hoxpacd_e": -1.0}, "id": "4HOXPACDtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Murein Recycling", "name": "Tetrapeptide L,D-carboxypeptidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["4PCP"]}, "metabolites": {"h2o_c": -1.0, "ala__D_c": 1.0, "LalaDgluMdapDala_c": -1.0, "LalaDgluMdap_c": 1.0}, "id": "4PCP", "gene_reaction_rule": "STM1800"}, {"subsystem": "Murein Recycling", "name": "Tetrapeptide L,D-carboxypeptidase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["4PCPpp"]}, "metabolites": {"LalaDgluMdapDala_p": -1.0, "h2o_p": -1.0, "LalaDgluMdap_p": 1.0, "ala__D_p": 1.0}, "id": "4PCPpp", "gene_reaction_rule": ""}, {"subsystem": "Murein Recycling", "name": "Tetrapeptide (LalaDgluMdapDala) transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["4PEPTabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "LalaDgluMdapDala_c": 1.0, "LalaDgluMdapDala_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "4PEPTabcpp", "gene_reaction_rule": "STM1746_S and STM1745 and STM1744 and STM1743 and STM1742"}, {"subsystem": "Transport Outer Membrane Porin", "name": "LalaDgluMdapDala (pentapeptide) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["4PEPTtex"]}, "metabolites": {"LalaDgluMdapDala_p": 1.0, "LalaDgluMdapDala_e": -1.0}, "id": "4PEPTtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Alternate Carbon Metabolism", "name": "5-dehydro-D-gluconate reductase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["5DGLCNR"]}, "metabolites": {"5dglcn_c": -1.0, "glcn_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0}, "id": "5DGLCNR", "gene_reaction_rule": "STM4483"}, {"subsystem": "Transport Inner Membrane", "name": "5-Dehydro-D-gluconate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["5DGLCNt2rpp"]}, "metabolites": {"5dglcn_p": -1.0, "5dglcn_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "5DGLCNt2rpp", "gene_reaction_rule": "STM4482"}, {"subsystem": "Transport Outer Membrane Porin", "name": "5-Dehydro-D-gluconate transport via diffusion (extracellular to 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"notes": {"original_bigg_ids": ["AACPS1"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "ACP_c": -1.0, "amp_c": 1.0, "myrsACP_c": 1.0, "ttdca_c": -1.0}, "id": "AACPS1", "gene_reaction_rule": "STM3010 and STM1196"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase  (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS2"]}, "metabolites": {"atp_c": -1.0, "tdeACP_c": 1.0, "ppi_c": 1.0, "ACP_c": -1.0, "amp_c": 1.0, "ttdcea_c": -1.0}, "id": "AACPS2", "gene_reaction_rule": "STM3010 and STM1196"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase  (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS3"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "ACP_c": -1.0, "amp_c": 1.0, "palmACP_c": 1.0, "hdca_c": -1.0}, "id": "AACPS3", "gene_reaction_rule": "STM3010 and STM1196"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase  (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS4"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "ACP_c": -1.0, "hdcea_c": -1.0, "amp_c": 1.0, "hdeACP_c": 1.0}, "id": "AACPS4", "gene_reaction_rule": "STM3010 and STM1196"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase  (n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS5"]}, "metabolites": {"ocdcea_c": -1.0, "atp_c": -1.0, "octeACP_c": 1.0, "ACP_c": -1.0, "amp_c": 1.0, "ppi_c": 1.0}, "id": "AACPS5", "gene_reaction_rule": "STM3010 and STM1196"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase  (n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS6"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "ACP_c": -1.0, "amp_c": 1.0, "ocdca_c": -1.0, "ocdcaACP_c": 1.0}, "id": "AACPS6", "gene_reaction_rule": "STM3010 and STM1196"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase  (n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS7"]}, "metabolites": {"atp_c": -1.0, "ddca_c": -1.0, "ppi_c": 1.0, "ACP_c": -1.0, "amp_c": 1.0, "ddcaACP_c": 1.0}, "id": "AACPS7", "gene_reaction_rule": "STM3010 and STM1196"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase  (n-C10:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS8"]}, "metabolites": {"dcaACP_c": 1.0, "atp_c": -1.0, "ppi_c": 1.0, "ACP_c": -1.0, "amp_c": 1.0, "dca_c": -1.0}, "id": "AACPS8", "gene_reaction_rule": "STM3010 and STM1196"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase  (n-C8:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS9"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 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"gene_reaction_rule": "STM3664"}, {"subsystem": "Arginine and Proline Metabolism", "name": "4-aminobutyrate transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ABTA"]}, "metabolites": {"akg_c": -1.0, "glu__L_c": 1.0, "sucsal_c": 1.0, "4abut_c": -1.0}, "id": "ABTA", "gene_reaction_rule": "STM2792"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Aminobutyraldehyde dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ABUTD"]}, "metabolites": {"h2o_c": -1.0, "4abutn_c": -1.0, "4abut_c": 1.0, "h_c": 2.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "ABUTD", "gene_reaction_rule": "STM1597"}, {"subsystem": "Transport Inner Membrane", "name": "4-aminobutyrate transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ABUTt2pp"]}, "metabolites": {"4abut_p": -1.0, "h_c": 1.0, "h_p": -1.0, "4abut_c": 1.0}, "id": "ABUTt2pp", "gene_reaction_rule": "STM2793"}, {"subsystem": "Transport Outer Membrane Porin", "name": "4-aminobutyrate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ABUTtex"]}, "metabolites": {"4abut_e": -1.0, "4abut_p": 1.0}, "id": "ABUTtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Acetoacetate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACtex"]}, "metabolites": {"acac_p": 1.0, "acac_e": -1.0}, "id": "ACACtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Pyruvate Metabolism", "name": "Acetaldehyde dehydrogenase (acetylating)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACALD"]}, "metabolites": {"accoa_c": 1.0, "acald_c": -1.0, "coa_c": -1.0, "h_c": 1.0, "nad_c": -1.0, "nadh_c": 1.0}, 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"agdpcbi_c": 1.0}, "id": "ACBIPGT", "gene_reaction_rule": "STM2018"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA carboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACCOAC"]}, "metabolites": {"malcoa_c": 1.0, "adp_c": 1.0, "atp_c": -1.0, "hco3_c": -1.0, "h_c": 1.0, "accoa_c": -1.0, "pi_c": 1.0}, "id": "ACCOAC", "gene_reaction_rule": "STM0232 and STM2366 and STM3379 and STM3380"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Acetate-CoA ligase (ADP-forming)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACCOAL"]}, "metabolites": {"ppcoa_c": 1.0, "atp_c": -1.0, "ppa_c": -1.0, "coa_c": -1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "ACCOAL", "gene_reaction_rule": "STM0371 or STM4275"}, {"subsystem": "Alternate Carbon Metabolism", "name": "N-acetyl-D-galactosamine 1-phosphatase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGAL1PPpp"]}, "metabolites": 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STM1473 or STM2267"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Acetylglutamate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGK"]}, "metabolites": {"acg5p_c": 1.0, "acglu_c": -1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "ACGK", "gene_reaction_rule": "STM4122"}, {"subsystem": "Arginine and Proline Metabolism", "name": "N-acetylglutamate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGS"]}, "metabolites": {"glu__L_c": -1.0, "acglu_c": 1.0, "coa_c": 1.0, "h_c": 1.0, "accoa_c": -1.0}, "id": "ACGS", "gene_reaction_rule": "STM2992"}, {"subsystem": "Valine Leucine and Isoleucine Metabolism", "name": "2-aceto-2-hydroxybutanoate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACHBS"]}, "metabolites": {"2ahbut_c": 1.0, "2obut_c": -1.0, "pyr_c": -1.0, "co2_c": 1.0, "h_c": -1.0}, "id": "ACHBS", "gene_reaction_rule": "(STM3795 and STM3796) or (STM3901 and STM3902)"}, {"subsystem": "Pyruvate Metabolism", "name": "Acetate kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACKr"]}, "metabolites": {"ac_c": -1.0, "actp_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "ACKr", "gene_reaction_rule": "STM3242 or STM2337 or STM1883"}, {"subsystem": "Valine Leucine and Isoleucine Metabolism", "name": "Acetolactate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACLS"]}, "metabolites": {"pyr_c": -2.0, "co2_c": 1.0, "h_c": -1.0, "alac__S_c": 1.0}, "id": "ACLS", "gene_reaction_rule": "(STM3795 and STM3796) or (STM3901 and STM3902)"}, {"subsystem": "Alternate Carbon Metabolism", "name": "N-acetylmuramate 6-phosphate hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACM6PH"]}, "metabolites": {"acgam6p_c": 1.0, "h2o_c": -1.0, "lac__D_c": 1.0, "acmum6p_c": -1.0}, "id": "ACM6PH", "gene_reaction_rule": ""}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetyl-D-mannosaminuronic acid transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACMAMUT"]}, "metabolites": {"udp_c": 1.0, "unagamu_c": 1.0, "h_c": 1.0, "uacmamu_c": -1.0, "unaga_c": -1.0}, "id": "ACMAMUT", "gene_reaction_rule": "STM3929"}, {"subsystem": "Transport Inner Membrane", "name": "N-acetyl-D-mannosamine transport via PTS  (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACMANAptspp"]}, "metabolites": {"acmana_p": -1.0, "pep_c": -1.0, "pyr_c": 1.0, "acmanap_c": 1.0}, "id": "ACMANAptspp", "gene_reaction_rule": "STM1830 and STM1831 and STM1832 and STM2431 and STM2432"}, {"subsystem": "Transport Outer Membrane Porin", "name": "N-acetyl-D-mannosamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACMANAtex"]}, "metabolites": {"acmana_p": 1.0, "acmana_e": -1.0}, "id": "ACMANAtex", "gene_reaction_rule": "STM2267 or STM0320 or STM0999 or STM1473"}, {"subsystem": "Transport Outer Membrane Porin", "name": "N-acetylmuramate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACMUMtex"]}, "metabolites": {"acmum_e": -1.0, "acmum_p": 1.0}, "id": "ACMUMtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "N-acetylneuraminate proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACNAMt2pp"]}, "metabolites": {"acnam_p": -1.0, "h_c": 1.0, "h_p": -1.0, "acnam_c": 1.0}, "id": "ACNAMt2pp", "gene_reaction_rule": "STM3338"}, {"subsystem": "Transport Outer Membrane", "name": "N-acetylneuraminate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACNAMtex"]}, "metabolites": {"acnam_e": -1.0, "acnam_p": 1.0}, "id": "ACNAMtex", "gene_reaction_rule": "STM0999 or STM2267"}, {"subsystem": "Alternate Carbon Metabolism", "name": "N-Acetylneuraminate lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACNML"]}, "metabolites": {"pyr_c": 1.0, "acmana_c": 1.0, "acnam_c": -1.0}, "id": "ACNML", "gene_reaction_rule": "STM3339"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (butanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOAD1f"]}, "metabolites": {"btcoa_c": -1.0, "fadh2_c": 1.0, "b2coa_c": 1.0, "fad_c": -1.0}, "id": "ACOAD1f", "gene_reaction_rule": "STM0309"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (hexanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOAD2f"]}, "metabolites": {"fadh2_c": 1.0, "fad_c": -1.0, "hxcoa_c": -1.0, "hx2coa_c": 1.0}, "id": "ACOAD2f", "gene_reaction_rule": "STM0309"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (octanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOAD3f"]}, "metabolites": {"oc2coa_c": 1.0, "fadh2_c": 1.0, "occoa_c": -1.0, "fad_c": -1.0}, "id": "ACOAD3f", "gene_reaction_rule": "STM0309"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (decanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOAD4f"]}, "metabolites": {"fadh2_c": 1.0, "dc2coa_c": 1.0, "dcacoa_c": -1.0, "fad_c": -1.0}, "id": "ACOAD4f", "gene_reaction_rule": "STM0309"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (dodecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOAD5f"]}, "metabolites": {"ddcacoa_c": -1.0, "fadh2_c": 1.0, "fad_c": -1.0, "dd2coa_c": 1.0}, "id": "ACOAD5f", "gene_reaction_rule": "STM0309"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (tetradecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOAD6f"]}, "metabolites": {"fadh2_c": 1.0, "tdcoa_c": -1.0, "fad_c": -1.0, "td2coa_c": 1.0}, "id": "ACOAD6f", "gene_reaction_rule": "STM0309"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (hexadecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOAD7f"]}, "metabolites": {"pmtcoa_c": -1.0, "fadh2_c": 1.0, "hdd2coa_c": 1.0, "fad_c": -1.0}, "id": "ACOAD7f", "gene_reaction_rule": "STM0309"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (octadecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOAD8f"]}, "metabolites": {"stcoa_c": -1.0, "od2coa_c": 1.0, "fadh2_c": 1.0, "fad_c": -1.0}, "id": "ACOAD8f", "gene_reaction_rule": "STM0309"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA ACP transacylase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOATA"]}, "metabolites": {"acACP_c": 1.0, "ACP_c": -1.0, "coa_c": 1.0, "accoa_c": -1.0}, "id": "ACOATA", "gene_reaction_rule": "STM1196 and STM1193"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Acetylornithine deacetylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACODA"]}, "metabolites": {"h2o_c": -1.0, "orn_c": 1.0, "ac_c": 1.0, "acorn_c": -1.0}, "id": "ACODA", "gene_reaction_rule": "STM4120"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Arabinose modified core oligosaccharide lipid A transport via vector (periplasm to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACOLIPAtex"]}, "metabolites": {"acolipa_p": -1.0, "acolipa_e": 1.0}, "id": "ACOLIPAtex", "gene_reaction_rule": ""}, {"subsystem": "Unassigned", "name": "Aconitate isomerase (spontaneous)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACONIs"]}, "metabolites": {"acon_T_c": -1.0, "acon_C_c": 1.0}, "id": "ACONIs", "gene_reaction_rule": "s0001"}, {"subsystem": "Citric Acid Cycle", "name": "Aconitase (half-reaction A, Citrate hydro-lyase)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACONTa"]}, "metabolites": {"h2o_c": 1.0, "acon_C_c": 1.0, "cit_c": -1.0}, "id": "ACONTa", "gene_reaction_rule": "STM0158 or STM1712"}, {"subsystem": "Citric Acid Cycle", "name": "Aconitase (half-reaction B, Isocitrate hydro-lyase)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACONTb"]}, "metabolites": {"h2o_c": -1.0, "icit_c": 1.0, "acon_C_c": -1.0}, "id": "ACONTb", "gene_reaction_rule": "STM0158 or STM1712"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Acetylornithine transaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOTA"]}, "metabolites": {"akg_c": -1.0, "glu__L_c": 1.0, "acorn_c": -1.0, "acg5sa_c": 1.0}, "id": "ACOTA", "gene_reaction_rule": "STM3468 or STM1303"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Acyl-carrier protein synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACPS1"]}, "metabolites": {"pap_c": 1.0, "ACP_c": 1.0, "coa_c": -1.0, "h_c": 1.0, "apoACP_c": -1.0}, "id": "ACPS1", "gene_reaction_rule": "STM2577 or STM3583"}, {"subsystem": "Pyruvate Metabolism", "name": "Acetyl-CoA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACS"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "coa_c": -1.0, "amp_c": 1.0, "accoa_c": 1.0, "ac_c": -1.0}, "id": "ACS", "gene_reaction_rule": "STM4275"}, {"subsystem": "Transport Outer Membrane Porin", "name": "O-Acetyl-L-serine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACSERtex"]}, "metabolites": {"acser_p": 1.0, "acser_e": -1.0}, "id": "ACSERtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "O-Acetyl-L-serine export via facilitated transport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACSERtpp"]}, "metabolites": {"acser_p": 1.0, "acser_c": -1.0}, "id": "ACSERtpp", "gene_reaction_rule": "STM2645 or STM1517"}, {"subsystem": "Transport Inner Membrane", "name": "Acetate reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACt2rpp"]}, "metabolites": {"ac_p": -1.0, "ac_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "ACt2rpp", "gene_reaction_rule": ""}, {"subsystem": "Transport Inner Membrane", "name": "Na+/Acetate symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACt4pp"]}, "metabolites": {"na1_p": -1.0, "ac_p": -1.0, "ac_c": 1.0, "na1_c": 1.0}, "id": "ACt4pp", "gene_reaction_rule": "STM4273"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Acetate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACtex"]}, "metabolites": {"ac_p": 1.0, "ac_e": -1.0}, "id": "ACtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Adenosine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADA"]}, "metabolites": {"h2o_c": -1.0, "nh4_c": 1.0, "adn_c": -1.0, "h_c": -1.0, "ins_c": 1.0}, "id": "ADA", "gene_reaction_rule": "STM1463"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "4-aminobenzoate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADCL"]}, "metabolites": {"pyr_c": 1.0, "4adcho_c": -1.0, "4abz_c": 1.0, "h_c": 1.0}, "id": "ADCL", "gene_reaction_rule": "STM1198"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "4-amino-4-deoxychorismate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADCS"]}, "metabolites": {"glu__L_c": 1.0, "4adcho_c": 1.0, "chor_c": -1.0, "gln__L_c": -1.0}, "id": "ADCS", "gene_reaction_rule": "STM3469 and STM1824"}, {"subsystem": "Transport Inner Membrane", "name": "Adenine transport via proton symport (reversible) (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ADEt2rpp"]}, "metabolites": {"ade_p": -1.0, "ade_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "ADEt2rpp", "gene_reaction_rule": "STM3747"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Adenine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ADEtex"]}, "metabolites": {"ade_p": 1.0, "ade_e": -1.0}, "id": "ADEtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Adenylate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADK1"]}, "metabolites": {"amp_c": -1.0, "atp_c": -1.0, "adp_c": 2.0}, "id": "ADK1", "gene_reaction_rule": "STM0488"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Adentylate kinase (GTP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ADK3"]}, "metabolites": {"gdp_c": 1.0, "gtp_c": -1.0, "amp_c": -1.0, "adp_c": 1.0}, "id": "ADK3", "gene_reaction_rule": "STM0488"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Adentylate kinase (ITP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ADK4"]}, "metabolites": {"amp_c": -1.0, "itp_c": -1.0, "idp_c": 1.0, "adp_c": 1.0}, "id": "ADK4", "gene_reaction_rule": "STM0488"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Adenosylmethionine decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": 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"gene_reaction_rule": "STM0051"}, {"subsystem": "Transport Inner Membrane", "name": "Adenosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADNt2pp", "ADNt2rpp"]}, "metabolites": {"adn_c": 1.0, "h_c": 1.0, "h_p": -1.0, "adn_p": -1.0}, "id": "ADNt2pp_copy1", "gene_reaction_rule": "STM3113 or STM2409"}, {"subsystem": "Transport Inner Membrane", "name": "Adenosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ADNt2pp", "ADNt2rpp"]}, "metabolites": {"adn_c": 1.0, "h_c": 1.0, "h_p": -1.0, "adn_p": -1.0}, "id": "ADNt2pp_copy2", "gene_reaction_rule": "STM2421"}, {"subsystem": "Transport Outer Membrane", "name": "Adenosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ADNtex"]}, "metabolites": {"adn_e": -1.0, "adn_p": 1.0}, "id": "ADNtex", "gene_reaction_rule": "STM0413"}, {"subsystem": "Transport Inner Membrane", "name": "Adenosylcobalamin transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADOCBLabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "adocbl_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "adocbl_p": -1.0, "pi_c": 1.0}, "id": "ADOCBLabcpp", "gene_reaction_rule": "STM1340 and STM1342 and STM0206"}, {"subsystem": "Transport Outer Membrane", "name": "Adenosylcobalimin transport via ton system (extermal)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADOCBLtonex"]}, "metabolites": {"adocbl_p": 1.0, "h_c": 1.0, "h_p": -1.0, "adocbl_e": -1.0}, "id": "ADOCBLtonex", "gene_reaction_rule": "STM4130 and (STM1737 and STM3158 and STM3159)"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "ADPribose diphosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADPRDP"]}, "metabolites": {"h2o_c": -1.0, "r5p_c": 1.0, "h_c": 2.0, "adprib_c": -1.0, "amp_c": 1.0}, "id": "ADPRDP", "gene_reaction_rule": "STM3185"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Adenine phosphoribosyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADPT"]}, "metabolites": {"ppi_c": 1.0, "ade_c": -1.0, "amp_c": 1.0, "prpp_c": -1.0}, "id": "ADPT", "gene_reaction_rule": "STM0483"}, {"subsystem": "Cysteine Metabolism", "name": "Adenylyl-sulfate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADSK"]}, "metabolites": {"adp_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "paps_c": 1.0, "aps_c": -1.0}, "id": "ADSK", "gene_reaction_rule": "STM2933"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Adenylsuccinate lyase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ADSL1r"]}, "metabolites": {"fum_c": 1.0, "amp_c": 1.0, "dcamp_c": -1.0}, "id": "ADSL1r", "gene_reaction_rule": "STM1232"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Adenylosuccinate lyase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ADSL2r"]}, "metabolites": {"25aics_c": -1.0, "fum_c": 1.0, "aicar_c": 1.0}, "id": "ADSL2r", "gene_reaction_rule": "STM1232"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Adenylosuccinate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADSS"]}, "metabolites": {"gdp_c": 1.0, "asp__L_c": -1.0, "gtp_c": -1.0, "h_c": 2.0, "pi_c": 1.0, "imp_c": -1.0, "dcamp_c": 1.0}, "id": "ADSS", "gene_reaction_rule": "STM4366"}, {"subsystem": "Alternate Carbon Metabolism", "name": "N-acetylglucosamine-6-phosphate deacetylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGDC"]}, "metabolites": {"h2o_c": -1.0, "ac_c": 1.0, "acgam6p_c": -1.0, "gam6p_c": 1.0}, "id": "AGDC", "gene_reaction_rule": "STM0683"}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tripeptide amidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM3PA"]}, "metabolites": {"h2o_c": -1.0, "anhgm3p_c": -1.0, "LalaDgluMdap_c": 1.0, "anhgm_c": 1.0}, "id": "AGM3PA", "gene_reaction_rule": "STM0146"}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tripeptide amidase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM3PApp"]}, "metabolites": {"h2o_p": -1.0, "anhgm_p": 1.0, "anhgm3p_p": -1.0, "LalaDgluMdap_p": 1.0}, "id": "AGM3PApp", "gene_reaction_rule": "STM4358 or STM2450 or STM2991"}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tripeptide beta -1,4-N-acetylglucosaminidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM3PH"]}, "metabolites": {"acgam_c": 1.0, "h2o_c": -1.0, "anhgm3p_c": -1.0, "anhm3p_c": 1.0}, "id": "AGM3PH", "gene_reaction_rule": "STM1209"}, {"subsystem": "Murein Recycling", "name": "GlcNAc-anhMurNAc tripeptide transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM3Pt2pp"]}, "metabolites": {"h_p": -1.0, "anhgm3p_c": 1.0, "anhgm3p_p": -1.0, "h_c": 1.0}, "id": "AGM3Pt2pp", "gene_reaction_rule": "STM0444"}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide amidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM4PA"]}, "metabolites": {"h2o_c": -1.0, "anhgm4p_c": -1.0, "LalaDgluMdapDala_c": 1.0, "anhgm_c": 1.0}, "id": "AGM4PA", "gene_reaction_rule": "STM0146"}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide amidase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM4PApp"]}, "metabolites": {"LalaDgluMdapDala_p": 1.0, "h2o_p": -1.0, "anhgm_p": 1.0, "anhgm4p_p": -1.0}, "id": "AGM4PApp", "gene_reaction_rule": "STM2991 or STM4358 or STM2450"}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide L,D-carboxypeptidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM4PCP"]}, "metabolites": {"ala__D_c": 1.0, "h2o_c": -1.0, "anhgm4p_c": -1.0, "anhgm3p_c": 1.0}, "id": "AGM4PCP", "gene_reaction_rule": "STM1800"}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide L,D-carboxypeptidase (periplasmic)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM4PCPpp"]}, "metabolites": {"h2o_p": -1.0, "ala__D_p": 1.0, "anhgm3p_p": 1.0, "anhgm4p_p": -1.0}, "id": "AGM4PCPpp", "gene_reaction_rule": ""}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide beta -1,4-N-acetylglucosaminidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM4PH"]}, "metabolites": {"acgam_c": 1.0, "h2o_c": -1.0, "anhgm4p_c": -1.0, "anhm4p_c": 1.0}, "id": "AGM4PH", "gene_reaction_rule": "STM1209"}, {"subsystem": "Murein Recycling", "name": "GlcNAc-anhMurNAc tetrapeptide transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM4Pt2pp"]}, "metabolites": {"anhgm4p_c": 1.0, "h_c": 1.0, "h_p": -1.0, "anhgm4p_p": -1.0}, "id": "AGM4Pt2pp", "gene_reaction_rule": "STM0444"}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl beta -1,4-N-acetylglucosaminidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGMH"]}, "metabolites": {"acgam_c": 1.0, "anhm_c": 1.0, "h2o_c": -1.0, "anhgm_c": -1.0}, "id": "AGMH", "gene_reaction_rule": "STM1209"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "ADP-D-glycero-D-manno-heptose epimerase", 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["AGMtex"]}, "metabolites": {"agm_p": 1.0, "agm_e": -1.0}, "id": "AGMtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-tetradecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT120"]}, "metabolites": {"1ddecg3p_c": -1.0, "ACP_c": 1.0, "pa120_c": 1.0, "ddcaACP_c": -1.0}, "id": "AGPAT120", "gene_reaction_rule": "STM3173"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-tetradecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT140"]}, "metabolites": {"1tdecg3p_c": -1.0, "pa140_c": 1.0, "ACP_c": 1.0, "myrsACP_c": -1.0}, "id": "AGPAT140", "gene_reaction_rule": "STM3173"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-tetradec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT141"]}, "metabolites": {"tdeACP_c": -1.0, "pa141_c": 1.0, "ACP_c": 1.0, "1tdec7eg3p_c": -1.0}, "id": "AGPAT141", "gene_reaction_rule": "STM3173"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-hexadecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT160"]}, "metabolites": {"pa160_c": 1.0, "ACP_c": 1.0, "1hdecg3p_c": -1.0, "palmACP_c": -1.0}, "id": "AGPAT160", "gene_reaction_rule": "STM3173"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-hexadec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT161"]}, "metabolites": {"pa161_c": 1.0, "1hdec9eg3p_c": -1.0, "ACP_c": 1.0, "hdeACP_c": -1.0}, "id": "AGPAT161", "gene_reaction_rule": "STM3173"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-octadecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT180"]}, "metabolites": {"ocdcaACP_c": -1.0, "ACP_c": 1.0, "1odecg3p_c": -1.0, "pa180_c": 1.0}, "id": "AGPAT180", "gene_reaction_rule": "STM3173"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-octadec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT181"]}, "metabolites": {"1odec11eg3p_c": -1.0, "octeACP_c": -1.0, "ACP_c": 1.0, "pa181_c": 1.0}, "id": "AGPAT181", "gene_reaction_rule": "STM3173"}, {"subsystem": "Arginine and Proline Metabolism", "name": "N-acetyl-g-glutamyl-phosphate reductase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AGPR"]}, "metabolites": {"nadp_c": -1.0, "nadph_c": 1.0, "acg5p_c": 1.0, "acg5sa_c": -1.0, "h_c": 1.0, "pi_c": -1.0}, "id": "AGPR", "gene_reaction_rule": "STM4121"}, {"subsystem": "Methionine Metabolism", "name": "S-adenosylhomocysteine nucleosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AHCYSNS"]}, "metabolites": {"ahcys_c": -1.0, "h2o_c": -1.0, "ade_c": 1.0, "rhcys_c": 1.0}, "id": "AHCYSNS", "gene_reaction_rule": "STM0207"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylaminoimidazolecarboxamide formyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AICART"]}, "metabolites": {"aicar_c": -1.0, "fprica_c": 1.0, "10fthf_c": -1.0, "thf_c": 1.0}, "id": "AICART", "gene_reaction_rule": "STM4176"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylaminoimidazole carboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AIRC2"]}, "metabolites": {"5caiz_c": 1.0, "atp_c": -1.0, "hco3_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "air_c": -1.0, "pi_c": 1.0}, "id": "AIRC2", "gene_reaction_rule": "STM0533"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylaminoimidazole carboxylase (mutase rxn)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AIRC3"]}, "metabolites": {"5caiz_c": 1.0, "5aizc_c": -1.0}, "id": "AIRC3", "gene_reaction_rule": "STM0534"}, {"subsystem": "Citric Acid Cycle", "name": "2-Oxogluterate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AKGDH"]}, "metabolites": {"akg_c": -1.0, "nadh_c": 1.0, "succoa_c": 1.0, "coa_c": -1.0, "nad_c": -1.0, "co2_c": 1.0}, "id": "AKGDH", "gene_reaction_rule": "STM0154 and STM0736 and STM0737"}, {"subsystem": "Transport Inner Membrane", "name": "2-oxoglutarate reversible transport via symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AKGt2rpp"]}, "metabolites": {"akg_c": 1.0, "akg_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "AKGt2rpp", "gene_reaction_rule": "STM2654"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Alpha-ketoglutarate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AKGtex"]}, "metabolites": {"akg_p": 1.0, "akg_e": -1.0}, "id": "AKGtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "D-alanyl-D-alanine (DalaDala) transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAALAabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "alaala_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "alaala_c": 1.0}, "id": "ALAALAabcpp", "gene_reaction_rule": "STM3630 and STM3629 and STM3628 and STM3627 and STM3626"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "D-alanine-D-alanine ligase (reversible)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAALAr"]}, "metabolites": 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"gene_reaction_rule": "STM0934 or STM2555"}, {"subsystem": "tRNA Charging", "name": "Alanyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALATRS"]}, "metabolites": {"trnaala_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "ala__L_c": -1.0, "amp_c": 1.0, "alatrna_c": 1.0}, "id": "ALATRS", "gene_reaction_rule": "STM2827"}, {"subsystem": "Transport Inner Membrane", "name": "L-alanine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "ala__L_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "ala__L_p": -1.0}, "id": "ALAabcpp", "gene_reaction_rule": "STM3560 and STM3561 and STM3563 and STM3567 and STM3562"}, {"subsystem": "Transport Inner Membrane", "name": "L-alanine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAt2pp"]}, "metabolites": {"ala__L_c": 1.0, "h_c": 1.0, "h_p": -1.0, "ala__L_p": -1.0}, "id": "ALAt2pp", "gene_reaction_rule": "STM4398"}, {"subsystem": "Transport Inner Membrane", "name": "L-alanine transport in via sodium symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAt4pp"]}, "metabolites": {"na1_p": -1.0, "na1_c": 1.0, "ala__L_c": 1.0, "ala__L_p": -1.0}, "id": "ALAt4pp", "gene_reaction_rule": "STM0006"}, {"subsystem": "Transport Outer Membrane Porin", "name": "L-alanine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAtex"]}, "metabolites": {"ala__L_e": -1.0, "ala__L_p": 1.0}, "id": "ALAtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Aldehyde dehydrogenase (acetaldehyde, NADP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALDD2y"]}, "metabolites": {"h2o_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "acald_c": -1.0, "h_c": 2.0, "ac_c": 1.0}, "id": "ALDD2y", "gene_reaction_rule": "STM3680"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Aldehyde dehydrogenase (propanal, NADP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALDD3y"]}, "metabolites": {"h2o_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "ppa_c": 1.0, "ppal_c": -1.0, "h_c": 2.0}, "id": "ALDD3y", "gene_reaction_rule": "STM3680"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Allantoate amidohydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALLTAMH"]}, "metabolites": {"alltt_c": -1.0, "urdglyc_c": 1.0, "h2o_c": -2.0, "h_c": -2.0, "co2_c": 1.0, "nh4_c": 2.0}, "id": "ALLTAMH", "gene_reaction_rule": "STM0527"}, {"subsystem": "Nitrogen Metabolism", "name": "Allantoinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALLTN"]}, "metabolites": {"alltt_c": 1.0, "h2o_c": -1.0, "h_c": 1.0, "alltn_c": -1.0}, "id": "ALLTN", "gene_reaction_rule": "STM0523"}, {"subsystem": "Transport Inner Membrane", "name": "Allantoin transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALLTNt2rpp"]}, "metabolites": {"h_p": -1.0, "h_c": 1.0, "alltn_c": 1.0, "alltn_p": -1.0}, "id": "ALLTNt2rpp", "gene_reaction_rule": "STM0522"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Allantoin transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALLTNtex"]}, "metabolites": {"alltn_e": -1.0, "alltn_p": 1.0}, "id": "ALLTNtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Allose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALLtex"]}, "metabolites": {"all__D_p": 1.0, "all__D_e": -1.0}, "id": "ALLtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Methylglyoxal Metabolism", "name": "Aldose reductase (methylglyoxal)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALR2"]}, "metabolites": {"acetol_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "mthgxl_c": -1.0}, "id": "ALR2", "gene_reaction_rule": "STM3165 or STM0255 or STM1288"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Aldose reductase (acetol)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALR4x"]}, "metabolites": {"nadh_c": -1.0, "acetol_c": -1.0, "12ppd__R_c": 1.0, "nad_c": 1.0, "h_c": -1.0}, "id": "ALR4x", "gene_reaction_rule": "STM4108"}, {"subsystem": "Murein Recycling", "name": "Anhydrous-N-Acetylmuramyl-tripeptide amidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AM3PA"]}, "metabolites": {"anhm_c": 1.0, "h2o_c": -1.0, "LalaDgluMdap_c": 1.0, "anhm3p_c": -1.0}, "id": "AM3PA", "gene_reaction_rule": "STM0146"}, {"subsystem": "Murein Recycling", "name": "Anhydrous-N-Acetylmuramyl-tetrapeptide amidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AM4PA"]}, "metabolites": {"anhm_c": 1.0, "LalaDgluMdapDala_c": 1.0, "anhm4p_c": -1.0, "h2o_c": -1.0}, "id": "AM4PA", "gene_reaction_rule": "STM0146"}, {"subsystem": "Murein Recycling", "name": "Anhydrous-N-Acetylmuramyl-tetrapeptide L,D-carboxypeptidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AM4PCP"]}, "metabolites": {"h2o_c": -1.0, "ala__D_c": 1.0, "anhm4p_c": -1.0, "anhm3p_c": 1.0}, "id": "AM4PCP", "gene_reaction_rule": "STM1800"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Amylomaltase (maltotriose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMALT1"]}, "metabolites": {"glc__D_c": 1.0, "malt_c": -1.0, "malttr_c": -1.0, "maltttr_c": 1.0}, "id": "AMALT1", "gene_reaction_rule": "STM3513"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Amylomaltase (maltotetraose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMALT2"]}, "metabolites": {"glc__D_c": 1.0, "maltpt_c": 1.0, "malt_c": -1.0, "maltttr_c": -1.0}, "id": "AMALT2", "gene_reaction_rule": "STM3513"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Amylomaltase (maltopentaose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMALT3"]}, "metabolites": {"maltpt_c": -1.0, "glc__D_c": 1.0, "malt_c": -1.0, "malthx_c": 1.0}, "id": "AMALT3", "gene_reaction_rule": "STM3513"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Amylomaltase (maltohexaose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMALT4"]}, "metabolites": {"glc__D_c": 1.0, "malthx_c": -1.0, "malt_c": -1.0, "malthp_c": 1.0}, "id": "AMALT4", "gene_reaction_rule": "STM3513"}, {"subsystem": "Alternate Carbon Metabolism", "name": "N-acetylmannosamine 6-phosphate epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AMANAPEr"]}, "metabolites": {"acmanap_c": -1.0, "acgam6p_c": 1.0}, "id": "AMANAPEr", "gene_reaction_rule": "STM3337"}, {"subsystem": "Alternate Carbon Metabolism", "name": "N-acetyl-D-mannosamine kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMANK"]}, "metabolites": {"acmana_c": -1.0, "acmanap_c": 1.0, "atp_c": -1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "AMANK", "gene_reaction_rule": "STM3336"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Adenosylmethionine-8-amino-7-oxononanoate transaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AMAOTr"]}, "metabolites": {"8aonn_c": -1.0, "amet_c": -1.0, "amob_c": 1.0, "dann_c": 1.0}, "id": "AMAOTr", "gene_reaction_rule": "STM0793"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "S-adenosylmethione:2-demthylmenaquinole methyltransferase (menaquinone 8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMMQLT8"]}, "metabolites": {"amet_c": -1.0, "ahcys_c": 1.0, "2dmmql8_c": -1.0, "mql8_c": 1.0, "h_c": 1.0}, "id": "AMMQLT8", "gene_reaction_rule": "STM3970"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "4-amino-2-methyl-5-phosphomethylpyrimidine synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMPMS2"]}, "metabolites": {"h2o_c": -1.0, "nad_c": -1.0, "4ampm_c": 1.0, "h_c": 3.0, "for_c": 2.0, "air_c": -1.0, "nadh_c": 1.0}, "id": "AMPMS2", "gene_reaction_rule": "STM4164"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "AMP nucleosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMPN"]}, "metabolites": {"h2o_c": -1.0, "ade_c": 1.0, "r5p_c": 1.0, "amp_c": -1.0}, "id": "AMPN", "gene_reaction_rule": "STM2009"}, {"subsystem": "Cysteine Metabolism", "name": "Alanyl aminopeptidase (cys-gly)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMPTASECG"]}, "metabolites": {"cys__L_c": 1.0, "h2o_c": -1.0, "gly_c": 1.0, "cgly_c": -1.0}, "id": "AMPTASECG", "gene_reaction_rule": "STM1057 or STM0316 or STM4477 or STM2536"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Aminopeptidase (pro-gly)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMPTASEPG"]}, "metabolites": {"h2o_c": -1.0, "pro__L_c": 1.0, "gly_c": 1.0, "progly_c": -1.0}, "id": "AMPTASEPG", "gene_reaction_rule": "STM2536 or STM4477 or STM0316 or STM1057"}, {"subsystem": "Transport Outer Membrane Porin", "name": "AMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AMPtex"]}, "metabolites": {"amp_e": -1.0, "amp_p": 1.0}, "id": "AMPtex", "gene_reaction_rule": "STM0999 or STM1473 or STM2267 or STM0320"}, {"subsystem": "Transport Outer Membrane Porin", "name": "GlcNAc-anhMurNAc transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ANHGMtex"]}, "metabolites": {"anhgm_e": -1.0, "anhgm_p": 1.0}, "id": "ANHGMtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Murein Recycling", "name": "1,6-anhydrous-N-Acetylmuramate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ANHMK"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "anhm_c": -1.0, "acmum6p_c": 1.0}, "id": "ANHMK", "gene_reaction_rule": "STM1446"}, {"subsystem": "Tyrosine Tryptophan and Phenylalanine Metabolism", "name": "Anthranilate phosphoribosyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ANPRT"]}, "metabolites": {"anth_c": -1.0, "ppi_c": 1.0, "prpp_c": -1.0, "pran_c": 1.0}, "id": "ANPRT", "gene_reaction_rule": "STM1724"}, {"subsystem": "Tyrosine Tryptophan and Phenylalanine Metabolism", "name": "Anthranilate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ANS"]}, "metabolites": {"anth_c": 1.0, "glu__L_c": 1.0, "chor_c": -1.0, "h_c": 1.0, "pyr_c": 1.0, "gln__L_c": -1.0}, "id": "ANS", "gene_reaction_rule": "STM1724 and STM1723"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "L-2-amino-3-oxobutanoate decarboxylation (spontaneous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AOBUTDs"]}, "metabolites": {"h_c": -1.0, "co2_c": 1.0, "2aobut_c": -1.0, "aact_c": 1.0}, "id": "AOBUTDs", "gene_reaction_rule": "s0001"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "8-amino-7-oxononanoate synthase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AOXSr"]}, "metabolites": {"pmcoa_c": -1.0, "8aonn_c": 1.0, "ala__L_c": -1.0, "coa_c": 1.0, "h_c": -1.0, "co2_c": 1.0}, "id": "AOXSr", "gene_reaction_rule": "STM0795"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Ap4A hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AP4AH"]}, "metabolites": {"ap4a_c": -1.0, "h2o_c": -1.0, "adp_c": 2.0, "h_c": 2.0}, "id": "AP4AH", "gene_reaction_rule": "STM0088"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Ap5A hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AP5AH"]}, "metabolites": {"h_c": 2.0, "h2o_c": -1.0, "ap5a_c": -1.0, "atp_c": 1.0, "adp_c": 1.0}, "id": "AP5AH", "gene_reaction_rule": "STM0088"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "5-amino-6-(5-phosphoribosylamino)uracil reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["APRAUR"]}, "metabolites": {"5apru_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "5aprbu_c": 1.0, "h_c": -1.0}, "id": "APRAUR", "gene_reaction_rule": "STM0416"}, {"subsystem": "Alternate Carbon Metabolism", "name": "L-arabinose isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ARAI"]}, "metabolites": {"rbl__L_c": 1.0, "arab__L_c": -1.0}, "id": "ARAI", "gene_reaction_rule": "STM0102"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Aerobactin reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ARBTNR1"]}, "metabolites": {"arbtn_fe3_c": -2.0, "fe2_c": 2.0, "arbtn_c": 2.0, "fadh2_c": -1.0, "h_c": 2.0, "fad_c": 1.0}, "id": "ARBTNR1", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Aerobactin reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ARBTNR2"]}, "metabolites": {"arbtn_fe3_c": -2.0, "fe2_c": 2.0, "arbtn_c": 2.0, "fmnh2_c": -1.0, "fmn_c": 1.0, "h_c": 2.0}, "id": "ARBTNR2", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Aerobactin reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ARBTNR3"]}, "metabolites": {"rbflvrd_c": -1.0, "arbtn_fe3_c": -2.0, "fe2_c": 2.0, "arbtn_c": 2.0, "h_c": 2.0, "ribflv_c": 1.0}, "id": "ARBTNR3", "gene_reaction_rule": ""}, {"subsystem": "Transport Inner Membrane", "name": "Aerobactin transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ARBTNabcpp"]}, "metabolites": {"h2o_c": -1.0, "arbtn_fe3_p": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "arbtn_fe3_c": 1.0}, "id": "ARBTNabcpp", "gene_reaction_rule": "STM0194 and STM0192 and STM0193"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Aerobactin Fe-loading reaction (spontaneous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ARBTNexs"]}, "metabolites": {"arbtn_e": -1.0, "arbtn_fe3_e": 1.0, "fe3_e": -1.0}, "id": "ARBTNexs", "gene_reaction_rule": "s0001"}, {"subsystem": "Transport Outer Membrane", "name": "Aerobactin secretion (to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ARBTNtex"]}, "metabolites": {"arbtn_e": 1.0, "arbtn_p": -1.0, "h_p": -1.0, "h_c": 1.0}, "id": "ARBTNtex", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane", "name": "Aerobactin transport via ton system (extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ARBTNtonex"]}, "metabolites": {"h_p": -1.0, "arbtn_fe3_e": -1.0, "h_c": 1.0, "arbtn_fe3_p": 1.0}, "id": "ARBTNtonex", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Aerobactin secretion (to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ARBTNtpp"]}, "metabolites": {"h_p": -1.0, "h_c": 1.0, "arbtn_c": -1.0, "arbtn_p": 1.0}, "id": "ARBTNtpp", "gene_reaction_rule": ""}, {"subsystem": "Transport Inner Membrane", "name": "L-arabinose transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ARBt2rpp"]}, "metabolites": {"h_p": -1.0, "h_c": 1.0, "arab__L_p": -1.0, "arab__L_c": 1.0}, "id": "ARBt2rpp", "gene_reaction_rule": "STM3016"}, {"subsystem": "Transport Inner Membrane", "name": "L-arabinose transport via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ARBt3ipp"]}, "metabolites": {"h_c": 1.0, "h_p": -1.0, "arab__L_p": 1.0, "arab__L_c": -1.0}, "id": "ARBt3ipp", "gene_reaction_rule": "STM1522"}, {"subsystem": "Transport Outer Membrane Porin", "name": "L-arabinose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ARBtex"]}, "metabolites": {"arab__L_e": -1.0, "arab__L_p": 1.0}, "id": "ARBtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "Arginine/agmatine antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ARGAGMt7pp"]}, "metabolites": {"agm_p": 1.0, "agm_c": -1.0, "arg__L_c": 1.0, "arg__L_p": -1.0}, "id": "ARGAGMt7pp", "gene_reaction_rule": "STM4294"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Arginine decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ARGDC"]}, "metabolites": {"agm_c": 1.0, "co2_c": 1.0, "arg__L_c": -1.0, "h_c": -1.0}, "id": "ARGDC", "gene_reaction_rule": "STM4296 or STM3086"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Arginine decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ARGDCpp"]}, "metabolites": {"co2_p": 1.0, "agm_p": 1.0, "h_p": -1.0, "arg__L_p": -1.0}, "id": "ARGDCpp", "gene_reaction_rule": "STM3086"}, {"subsystem": "Transport Inner Membrane", "name": "Arginine/ornithine antiporter (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ARGORNt7pp"]}, "metabolites": {"arg__L_c": 1.0, "arg__L_p": -1.0, "orn_c": -1.0, "orn_p": 1.0}, "id": "ARGORNt7pp", "gene_reaction_rule": "STM1477"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Argininosuccinate lyase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ARGSL"]}, "metabolites": {"argsuc_c": -1.0, "fum_c": 1.0, "arg__L_c": 1.0}, "id": "ARGSL", "gene_reaction_rule": "STM4123"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Argininosuccinate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ARGSS"]}, "metabolites": {"atp_c": -1.0, "asp__L_c": -1.0, "ppi_c": 1.0, "argsuc_c": 1.0, "h_c": 1.0, "citr__L_c": -1.0, "amp_c": 1.0}, "id": "ARGSS", "gene_reaction_rule": "STM3290_S"}, {"subsystem": "tRNA Charging", "name": "Arginyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ARGTRS"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "argtrna_c": 1.0, "trnaarg_c": -1.0, "amp_c": 1.0, "arg__L_c": -1.0}, "id": "ARGTRS", "gene_reaction_rule": "STM1909"}, {"subsystem": "Transport Inner Membrane", "name": "L-arginine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ARGabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "arg__L_p": -1.0, "arg__L_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "ARGabcpp", "gene_reaction_rule": "(STM2355 and STM2352 and STM2351 and STM2353) or (STM0890 and STM0887 and STM0888 and STM0891 and STM0889)"}, {"subsystem": "Transport Inner Membrane", "name": "L-arginine transport out via proton antiport (cytoplasm to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ARGt3pp"]}, "metabolites": {"arg__L_c": -1.0, "h_c": 1.0, "h_p": -1.0, "arg__L_p": 1.0}, "id": "ARGt3pp", "gene_reaction_rule": "STM3066"}, {"subsystem": "Transport Outer Membrane Porin", "name": "L-arginine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ARGtex"]}, "metabolites": {"arg__L_e": -1.0, "arg__L_p": 1.0}, "id": "ARGtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Aspartate-semialdehyde dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ASAD"]}, "metabolites": {"aspsa_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "h_c": 1.0, "pi_c": -1.0, "4pasp_c": 1.0}, "id": "ASAD", "gene_reaction_rule": "STM3539"}, {"subsystem": "Alternate Carbon Metabolism", "name": "L-ascorbate 6-phosphate lactonase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASCBPL"]}, "metabolites": {"3dhgulnp_c": 1.0, "ascb6p_c": -1.0, "h_c": 1.0, "h2o_c": -1.0}, "id": "ASCBPL", "gene_reaction_rule": "STM4382"}, {"subsystem": "Transport Inner Membrane", "name": "L-ascorbate transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASCBptspp"]}, "metabolites": {"pep_c": -1.0, "ascb6p_c": 1.0, "ascb__L_p": -1.0, "pyr_c": 1.0}, "id": "ASCBptspp", "gene_reaction_rule": "STM2431 and STM2432 and STM4385 and STM4384 and STM4383_S"}, {"subsystem": "Transport Outer Membrane Porin", "name": "L-ascorbate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ASCBtex"]}, "metabolites": {"ascb__L_p": 1.0, "ascb__L_e": -1.0}, "id": "ASCBtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "L-asparaginase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASNN"]}, "metabolites": {"asp__L_c": 1.0, "asn__L_c": -1.0, "h2o_c": -1.0, "nh4_c": 1.0}, "id": "ASNN", "gene_reaction_rule": "STM1294 or STM0847 or STM3598"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "L-asparaginase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASNNpp"]}, "metabolites": {"h2o_p": -1.0, "asp__L_p": 1.0, "nh4_p": 1.0, "asn__L_p": -1.0}, "id": "ASNNpp", "gene_reaction_rule": "STM3106"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "Asparagine synthase (glutamine-hydrolysing)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASNS1"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "asp__L_c": -1.0, "asn__L_c": 1.0, "h_c": 1.0, "ppi_c": 1.0, "amp_c": 1.0, "glu__L_c": 1.0, "gln__L_c": -1.0}, "id": "ASNS1", "gene_reaction_rule": "STM0680"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "Asparagine synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASNS2"]}, "metabolites": {"atp_c": -1.0, "asp__L_c": -1.0, "asn__L_c": 1.0, "nh4_c": -1.0, "h_c": 1.0, "ppi_c": 1.0, "amp_c": 1.0}, "id": "ASNS2", "gene_reaction_rule": "STM3877"}, {"subsystem": "tRNA Charging", "name": "Asparaginyl tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASNTRS"]}, "metabolites": {"trnaasn_c": -1.0, "atp_c": -1.0, "asn__L_c": -1.0, "h_c": 1.0, "asntrna_c": 1.0, "ppi_c": 1.0, "amp_c": 1.0}, "id": "ASNTRS_1", "gene_reaction_rule": "STM1000"}, {"subsystem": "Transport Inner Membrane", "name": "L-asparagine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASNabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "asn__L_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "asn__L_p": -1.0, "pi_c": 1.0}, "id": "ASNabcpp", "gene_reaction_rule": ""}, {"subsystem": "Transport Inner Membrane", "name": "L-asparagine reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ASNt2rpp"]}, "metabolites": {"asn__L_p": -1.0, "asn__L_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "ASNt2rpp", "gene_reaction_rule": "STM1584"}, {"subsystem": "Transport Outer Membrane Porin", "name": "L-asparagine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ASNtex"]}, "metabolites": {"asn__L_p": 1.0, "asn__L_e": -1.0}, "id": "ASNtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Arsenite transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ASO3tex"]}, "metabolites": {"aso3_p": 1.0, "aso3_e": -1.0}, "id": "ASO3tex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Aspartate 1-decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASP1DC"]}, "metabolites": {"asp__L_c": -1.0, "co2_c": 1.0, "h_c": -1.0, "ala_B_c": 1.0}, "id": "ASP1DC", "gene_reaction_rule": "STM0180"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Aspartate carbamoyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASPCT"]}, "metabolites": {"asp__L_c": -1.0, "cbasp_c": 1.0, "cbp_c": -1.0, "pi_c": 1.0, "h_c": 1.0}, "id": "ASPCT", "gene_reaction_rule": "STM4459 and STM4460"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Aspartate kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ASPK"]}, "metabolites": {"asp__L_c": -1.0, "4pasp_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "ASPK", "gene_reaction_rule": "STM0002 or STM4101 or STM4220"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "L-aspartate oxidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASPO3"]}, "metabolites": {"asp__L_c": -1.0, "q8h2_c": 1.0, "iasp_c": 1.0, "h_c": 1.0, "q8_c": -1.0}, "id": "ASPO3", "gene_reaction_rule": "STM2641"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "L-aspartate oxidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASPO4"]}, "metabolites": {"asp__L_c": -1.0, "iasp_c": 1.0, "mqn8_c": -1.0, "h_c": 1.0, "mql8_c": 1.0}, "id": "ASPO4", "gene_reaction_rule": "STM2641"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "L-aspartate oxidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASPO5"]}, "metabolites": {"asp__L_c": -1.0, "fum_c": -1.0, "succ_c": 1.0, "iasp_c": 1.0, "h_c": 1.0}, "id": "ASPO5", "gene_reaction_rule": "STM2641"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "L-aspartate oxidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASPO6"]}, "metabolites": {"asp__L_c": -1.0, "o2_c": -1.0, "iasp_c": 1.0, "h_c": 1.0, "h2o2_c": 1.0}, "id": "ASPO6", "gene_reaction_rule": "STM2641"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "L-aspartase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASPT"]}, "metabolites": {"asp__L_c": -1.0, "fum_c": 1.0, "nh4_c": 1.0}, "id": "ASPT", "gene_reaction_rule": "STM4326"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "Aspartate transaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ASPTA"]}, "metabolites": {"akg_c": -1.0, "asp__L_c": -1.0, "glu__L_c": 1.0, "oaa_c": 1.0}, "id": "ASPTA", "gene_reaction_rule": "STM0998"}, {"subsystem": "tRNA Charging", "name": "Aspartyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASPTRS"]}, "metabolites": {"asptrna_c": 1.0, "atp_c": -1.0, "asp__L_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "trnaasp_c": -1.0}, "id": "ASPTRS", "gene_reaction_rule": "STM1901"}, {"subsystem": "Transport Inner Membrane", "name": "L-aspartate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASPabcpp"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "atp_c": -1.0, "asp__L_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "asp__L_p": -1.0}, "id": "ASPabcpp", "gene_reaction_rule": "STM0665 and STM0664 and STM0663 and STM0662"}, {"subsystem": "Transport Inner Membrane", "name": "Aspartate transport via proton symport (2 H) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASPt2_2pp"]}, "metabolites": {"asp__L_c": 1.0, "asp__L_p": -1.0, "h_c": 2.0, "h_p": -2.0}, "id": "ASPt2_2pp", "gene_reaction_rule": "STM3614"}, {"subsystem": "Transport Inner Membrane", "name": "L-aspartate transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASPt2pp"]}, "metabolites": {"asp__L_c": 1.0, "asp__L_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "ASPt2pp", "gene_reaction_rule": "STM4283"}, {"subsystem": "Transport Outer Membrane Porin", "name": "L-aspartate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ASPtex"]}, "metabolites": {"asp__L_p": 1.0, "asp__L_e": -1.0}, "id": "ASPtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Arginine succinyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AST"]}, "metabolites": {"coa_c": 1.0, "succoa_c": -1.0, "sucarg_c": 1.0, "arg__L_c": -1.0, "h_c": 1.0}, "id": "AST", "gene_reaction_rule": "STM1304"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "L-allo-threonine dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ATHRDHr"]}, "metabolites": {"nadp_c": -1.0, "nadph_c": 1.0, "2aobut_c": 1.0, "athr__L_c": -1.0, "h_c": 1.0}, "id": "ATHRDHr", "gene_reaction_rule": "STM1511"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "ATP amine hydrolysis (spontaneous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ATPHs"]}, "metabolites": {"h2o_c": -1.0, "itp_c": 1.0, "nh4_c": 1.0, "atp_c": -1.0, "h_c": -1.0}, "id": "ATPHs", "gene_reaction_rule": "s0001"}, {"subsystem": "Unassigned", "name": "ATP maintenance requirement", "upper_bound": 8.39, "lower_bound": 8.39, "notes": {"original_bigg_ids": ["ATPM"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "ATPM", "gene_reaction_rule": ""}, {"subsystem": "Histidine Metabolism", "name": "ATP phosphoribosyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ATPPRT"]}, "metabolites": {"ppi_c": 1.0, "atp_c": -1.0, "prpp_c": -1.0, "prbatp_c": 1.0}, "id": "ATPPRT", "gene_reaction_rule": "STM2071"}, {"subsystem": "Oxidative Phosphorylation", "name": "ATP synthase (four protons for one ATP) (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ATPS4rpp"]}, "metabolites": {"h2o_c": 1.0, "h_p": -4.0, "atp_c": 1.0, "h_c": 3.0, "adp_c": -1.0, "pi_c": -1.0}, "id": "ATPS4rpp", "gene_reaction_rule": "((STM3869 and STM3870 and STM3871) and (STM3864 and STM3865 and STM3866 and STM3867 and STM3868)) or ((STM3869 and STM3870 and STM3871) and (STM3864 and STM3865 and STM3866 and STM3867 and STM3868) and STM3872)"}, {"subsystem": "Transport Inner Membrane", "name": "Beta-alanine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["BALAt2pp"]}, "metabolites": {"h_p": -1.0, "ala_B_p": -1.0, "ala_B_c": 1.0, "h_c": 1.0}, "id": "BALAt2pp", "gene_reaction_rule": "STM4398"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Beta-alanine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["BALAtex"]}, "metabolites": {"ala_B_e": -1.0, "ala_B_p": 1.0}, "id": "BALAtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Cysteine Metabolism", "name": "3',5'-bisphosphate nucleotidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["BPNT"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "pap_c": -1.0, "amp_c": 1.0}, "id": "BPNT", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Biotin sulfoxide reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["BSORx"]}, "metabolites": {"h2o_c": 1.0, "btn_c": 1.0, "btnso_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "nadh_c": -1.0}, "id": "BSORx", "gene_reaction_rule": "STM3644"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Biotin sulfoxide reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["BSORy"]}, "metabolites": {"h2o_c": 1.0, "btn_c": 1.0, "nadph_c": -1.0, "btnso_c": -1.0, "nadp_c": 1.0, "h_c": -1.0}, "id": "BSORy", "gene_reaction_rule": "STM3644"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Biotin synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["BTS4"]}, "metabolites": {"btn_c": 1.0, "dtbt_c": -1.0, "dad_5_c": 1.0, "s_c": -1.0, "h_c": 1.0, "met__L_c": 1.0, "amet_c": -1.0}, "id": "BTS4", "gene_reaction_rule": "STM0794"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Butanesulfonate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["BUTSO3tex"]}, "metabolites": {"butso3_p": 1.0, "butso3_e": -1.0}, "id": "BUTSO3tex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Butyrate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["BUTtex"]}, "metabolites": {"but_e": -1.0, "but_p": 1.0}, "id": "BUTtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Calcium (Ca+2) transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CA2t3pp"]}, "metabolites": {"h_c": 1.0, "h_p": -1.0, "ca2_p": 1.0, "ca2_c": -1.0}, "id": "CA2t3pp", "gene_reaction_rule": "STM1771"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Calcium (Ca+2) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CA2tex"]}, "metabolites": {"ca2_e": -1.0, "ca2_p": 1.0}, "id": "CA2tex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "Lysine/Cadaverine antiporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CADVtpp"]}, "metabolites": {"lys__L_c": 1.0, "h_p": -1.0, "15dap_p": 1.0, "h_c": 1.0, "lys__L_p": -1.0, "15dap_c": -1.0}, "id": "CADVtpp", "gene_reaction_rule": "STM2558"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Calcium / sodium antiporter (1:1)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CAt6pp"]}, "metabolites": {"na1_p": -1.0, "na1_c": 1.0, "ca2_c": -1.0, "ca2_p": 1.0}, "id": "CAt6pp", "gene_reaction_rule": "STM3314"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Cobinamide adenyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CBIAT"]}, "metabolites": {"pppi_c": 1.0, "cbi_c": -1.0, "adocbi_c": 1.0, "h_c": -1.0, "atp_c": -1.0}, "id": "CBIAT", "gene_reaction_rule": "STM1718"}, {"subsystem": "Transport Outer Membrane", "name": "Cobinamide transport via ton system (extermal)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CBItonex"]}, "metabolites": {"cbi_p": 1.0, "cbi_e": -1.0, "h_p": -1.0, "h_c": 1.0}, "id": "CBItonex", "gene_reaction_rule": "STM4130 and (STM1737 and STM3158 and STM3159)"}, {"subsystem": "Transport Inner Membrane", "name": "Cobinamide transport via ABC system (uptake, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CBIuabcpp"]}, "metabolites": {"cbi_p": -1.0, "h2o_c": -1.0, "atp_c": -1.0, "cbi_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "CBIuabcpp", "gene_reaction_rule": "STM1340 and STM1342 and STM0206"}, {"subsystem": "Transport Inner Membrane", "name": "Cob(1)alamin transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CBL1abcpp"]}, "metabolites": {"cbl1_p": -1.0, "h2o_c": -1.0, "atp_c": -1.0, "cbl1_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "CBL1abcpp", "gene_reaction_rule": "STM1340 and STM1342 and STM0206"}, {"subsystem": "Transport Outer Membrane", "name": "Cob(1)alamin transport via ton system (extermal)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CBL1tonex"]}, "metabolites": {"cbl1_p": 1.0, "cbl1_e": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "CBL1tonex", "gene_reaction_rule": "STM4130 and (STM1737 and STM3158 and STM3159)"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Carbamoyl-phosphate synthase (glutamine-hydrolysing)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CBPS"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -2.0, "hco3_c": -1.0, "glu__L_c": 1.0, "cbp_c": 1.0, "h_c": 2.0, "adp_c": 2.0, "pi_c": 1.0, "gln__L_c": -1.0}, "id": "CBPS", "gene_reaction_rule": "STM0066 and STM0067"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Cadmium (Cd+2) ABC transporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CD2abcpp"]}, "metabolites": {"h2o_c": -1.0, "cd2_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "cd2_p": 1.0}, "id": "CD2abcpp", "gene_reaction_rule": "STM3576"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Cadmium (Cd+2) transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CD2t3pp"]}, "metabolites": {"h_p": -1.0, "h_c": 1.0, "cd2_c": -1.0, "cd2_p": 1.0}, "id": "CD2t3pp", "gene_reaction_rule": "STM0758 or STM4061"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Cadmium (Cd+2) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CD2tex"]}, "metabolites": {"cd2_e": -1.0, "cd2_p": 1.0}, "id": "CD2tex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Cadmium (+2) transport in via permease (no H+)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CD2tpp"]}, "metabolites": {"cd2_p": -1.0, "cd2_c": 1.0}, "id": "CD2tpp", "gene_reaction_rule": "STM3190"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-Diacylglycerol pyrophostatase (n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDAPPA120"]}, "metabolites": {"h_c": 2.0, "cdpdddecg_c": -1.0, "h2o_c": -1.0, "pa120_c": 1.0, "cmp_c": 1.0}, "id": "CDAPPA120", "gene_reaction_rule": "STM4064"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-Diacylglycerol pyrophostatase (n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDAPPA140"]}, "metabolites": {"cdpdtdecg_c": -1.0, "h2o_c": -1.0, "pa140_c": 1.0, "h_c": 2.0, "cmp_c": 1.0}, "id": "CDAPPA140", "gene_reaction_rule": "STM4064"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-Diacylglycerol pyrophostatase (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDAPPA141"]}, "metabolites": {"pa141_c": 1.0, "cmp_c": 1.0, "h_c": 2.0, "h2o_c": -1.0, "cdpdtdec7eg_c": -1.0}, "id": "CDAPPA141", "gene_reaction_rule": "STM4064"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-Diacylglycerol pyrophostatase (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDAPPA160"]}, "metabolites": {"h_c": 2.0, "pa160_c": 1.0, "h2o_c": -1.0, "cdpdhdecg_c": -1.0, "cmp_c": 1.0}, "id": "CDAPPA160", "gene_reaction_rule": "STM4064"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-Diacylglycerol pyrophostatase (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDAPPA161"]}, "metabolites": {"pa161_c": 1.0, "h2o_c": -1.0, "cdpdhdec9eg_c": -1.0, "h_c": 2.0, "cmp_c": 1.0}, "id": "CDAPPA161", "gene_reaction_rule": "STM4064"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-Diacylglycerol pyrophostatase (n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDAPPA180"]}, "metabolites": {"cdpdodecg_c": -1.0, "cmp_c": 1.0, "h_c": 2.0, "h2o_c": -1.0, "pa180_c": 1.0}, "id": "CDAPPA180", "gene_reaction_rule": "STM4064"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-Diacylglycerol pyrophostatase (n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDAPPA181"]}, "metabolites": {"h_c": 2.0, "h2o_c": -1.0, "pa181_c": 1.0, "cdpdodec11eg_c": -1.0, "cmp_c": 1.0}, "id": "CDAPPA181", "gene_reaction_rule": "STM4064"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDPMEK"]}, "metabolites": {"4c2me_c": -1.0, "2p4c2me_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "CDPMEK", "gene_reaction_rule": "STM1779"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cyclopropane fatty acid synthase (Phosphatidylethanolamine, n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": 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(Phosphatidylglycerol, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CFAS180G"]}, "metabolites": {"ahcys_c": 2.0, "cpg180_c": 1.0, "pg181_c": -1.0, "h_c": 2.0, "amet_c": -2.0}, "id": "CFAS180G", "gene_reaction_rule": "STM1427"}, {"subsystem": "Transport Inner Membrane", "name": "L-Cysteinylglycine (Cys-Gly) transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CGLYabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "cgly_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "cgly_c": 1.0}, "id": "CGLYabcpp", "gene_reaction_rule": "STM3630 and STM3629 and STM3628 and STM3627 and STM3626"}, {"subsystem": "Transport Outer Membrane Porin", "name": "L-Cysteinylglycine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CGLYtex"]}, "metabolites": {"cgly_e": -1.0, "cgly_p": 1.0}, "id": "CGLYtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "Choline transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHLabcpp"]}, "metabolites": {"h2o_c": -1.0, "chol_p": -1.0, "atp_c": -1.0, "chol_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "CHLabcpp", "gene_reaction_rule": "STM2162 and STM2163 and STM2164 and STM2165"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Choline transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CHLtex"]}, "metabolites": {"chol_p": 1.0, "chol_e": -1.0}, "id": "CHLtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Tyrosine Tryptophan and Phenylalanine Metabolism", "name": "Chorismate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHORS"]}, "metabolites": {"chor_c": 1.0, "pi_c": 1.0, "3psme_c": -1.0}, "id": "CHORS", "gene_reaction_rule": "STM2384"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Chorismate pyruvate lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHRPL"]}, "metabolites": {"4hbz_c": 1.0, "chor_c": -1.0, "pyr_c": 1.0}, "id": "CHRPL", "gene_reaction_rule": "STM4233"}, {"subsystem": "Citric Acid Cycle", "name": "Citrate lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CITL"]}, "metabolites": {"ac_c": 1.0, "oaa_c": 1.0, "cit_c": -1.0}, "id": "CITL", "gene_reaction_rule": "((STM0621 and STM0622 and STM0623) or (STM0059 and STM0060 and STM0061)) and STM0620"}, {"subsystem": "Transport Inner Membrane", "name": "Citrate transport via succinate antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CITt7pp"]}, "metabolites": {"succ_p": 1.0, "succ_c": -1.0, "cit_p": -1.0, "cit_c": 1.0}, "id": "CITt7pp", "gene_reaction_rule": "STM0618"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Citrate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CITtex"]}, "metabolites": {"cit_e": -1.0, "cit_p": 1.0}, "id": "CITtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Citrate transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ICITtex"]}, "metabolites": {"icit_p": 1.0, "icit_e": -1.0}, "id": "ICITtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Cisaconitat transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACONCtex"]}, "metabolites": {"acon_C_e": -1.0, "acon_C_p": 1.0}, "id": "ACONCtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Cold lipid A transport via vector (periplasm to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLIPAtex"]}, "metabolites": {"lipa_cold_e": 1.0, "lipa_cold_p": -1.0}, "id": "CLIPAtex", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH120pp"]}, "metabolites": {"pg120_p": 1.0, "h2o_p": -1.0, "pa120_p": 1.0, "h_p": 1.0, "clpn120_p": -1.0}, "id": "CLPNH120pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH140pp"]}, "metabolites": {"pa140_p": 1.0, "h2o_p": -1.0, "pg140_p": 1.0, "clpn140_p": -1.0, "h_p": 1.0}, "id": "CLPNH140pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH141pp"]}, "metabolites": {"h2o_p": -1.0, "pg141_p": 1.0, "clpn141_p": -1.0, "h_p": 1.0, "pa141_p": 1.0}, "id": "CLPNH141pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH160pp"]}, "metabolites": {"pg160_p": 1.0, "h2o_p": -1.0, "clpn160_p": -1.0, "pa160_p": 1.0, "h_p": 1.0}, "id": "CLPNH160pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH161pp"]}, "metabolites": {"pa161_p": 1.0, "h2o_p": -1.0, "clpn161_p": -1.0, "h_p": 1.0, "pg161_p": 1.0}, "id": "CLPNH161pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH180pp"]}, "metabolites": {"pa180_p": 1.0, "h2o_p": -1.0, "clpn180_p": -1.0, "pg180_p": 1.0, "h_p": 1.0}, "id": "CLPNH180pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH181pp"]}, "metabolites": {"h2o_p": -1.0, "pg181_p": 1.0, "clpn181_p": -1.0, "h_p": 1.0, "pa181_p": 1.0}, "id": "CLPNH181pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin synthase (periplasmic, n-C12:0)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CLPNS120pp"]}, "metabolites": {"pg120_p": -2.0, "glyc_p": 1.0, "clpn120_p": 1.0}, "id": "CLPNS120pp", "gene_reaction_rule": "STM1739 or STM0812"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin synthase (periplasmic, n-C14:0)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CLPNS140pp"]}, "metabolites": {"clpn140_p": 1.0, "pg140_p": -2.0, "glyc_p": 1.0}, "id": "CLPNS140pp", "gene_reaction_rule": "STM1739 or STM0812"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin synthase (periplasmic, n-C14:1)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CLPNS141pp"]}, "metabolites": {"clpn141_p": 1.0, "pg141_p": -2.0, "glyc_p": 1.0}, "id": "CLPNS141pp", "gene_reaction_rule": "STM1739 or STM0812"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin synthase (periplasmic, n-C16:0)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CLPNS160pp"]}, "metabolites": {"pg160_p": -2.0, "clpn160_p": 1.0, "glyc_p": 1.0}, "id": "CLPNS160pp", "gene_reaction_rule": "STM1739 or STM0812"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin synthase (periplasmic, n-C16:1)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CLPNS161pp"]}, "metabolites": {"pg161_p": -2.0, "clpn161_p": 1.0, "glyc_p": 1.0}, "id": "CLPNS161pp", "gene_reaction_rule": "STM1739 or STM0812"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin synthase (periplasmic, n-C18:0)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CLPNS180pp"]}, "metabolites": {"clpn180_p": 1.0, "glyc_p": 1.0, "pg180_p": -2.0}, "id": "CLPNS180pp", "gene_reaction_rule": "STM1739 or STM0812"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin synthase (periplasmic, n-C18:1)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CLPNS181pp"]}, "metabolites": {"clpn181_p": 1.0, "glyc_p": 1.0, "pg181_p": -2.0}, "id": "CLPNS181pp", "gene_reaction_rule": "STM1739 or STM0812"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Chloride transport out via proton antiport (2:1) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLt3_2pp"]}, "metabolites": {"cl_p": -2.0, "h_c": -1.0, "h_p": 1.0, "cl_c": 2.0}, "id": "CLt3_2pp", "gene_reaction_rule": "STM0203 or STM1490"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Chloride (Cl-1) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CLtex"]}, "metabolites": {"cl_e": -1.0, "cl_p": 1.0}, "id": "CLtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "CMP nucleosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CMPN"]}, "metabolites": {"h2o_c": -1.0, "csn_c": 1.0, "r5p_c": 1.0, "cmp_c": -1.0}, "id": "CMPN", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "CMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CMPtex"]}, "metabolites": {"cmp_e": -1.0, "cmp_p": 1.0}, "id": "CMPtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "CO2 transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CO2tex"]}, "metabolites": {"co2_p": 1.0, "co2_e": -1.0}, "id": "CO2tex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "CO2 transporter via diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CO2tpp"]}, "metabolites": {"co2_p": -1.0, "co2_c": 1.0}, "id": "CO2tpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Cobalt (Co+2) ABC transporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["COBALT2abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "cobalt2_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "cobalt2_p": 1.0}, "id": "COBALT2abcpp", "gene_reaction_rule": "STM3576"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Cobalt (Co+2) transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["COBALT2t3pp"]}, "metabolites": {"h_c": 1.0, "h_p": -1.0, "cobalt2_c": -1.0, "cobalt2_p": 1.0}, "id": "COBALT2t3pp", "gene_reaction_rule": "STM4061 or STM0758"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Cobalt (Co+2) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["COBALT2tex"]}, "metabolites": {"cobalt2_e": -1.0, "cobalt2_p": 1.0}, "id": "COBALT2tex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Cobalt transport in via permease (no H+)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["COBALT2tpp", "Cobalt2abcppII"]}, "metabolites": {"cobalt2_p": -1.0, "cobalt2_c": 1.0}, "id": "COBALT2tpp_copy1", "gene_reaction_rule": "STM3190 or STM3952"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Core oligosaccharide lipid A transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["COLIPAabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "colipa_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "colipa_c": -1.0, "pi_c": 1.0}, "id": "COLIPAabcpp", "gene_reaction_rule": "STM0984"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Core oligosaccharide lipid A transport via vector (periplasm to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["COLIPAtex"]}, "metabolites": {"colipa_p": -1.0, "colipa_e": 1.0}, "id": "COLIPAtex", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Coprogen(Fe(III)) reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CPGNR1"]}, "metabolites": {"cpgn_c": -2.0, "fe2_c": 2.0, "fadh2_c": -1.0, "h_c": 2.0, "cpgn_un_c": 2.0, "fad_c": 1.0}, "id": "CPGNR1", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Coprogen(Fe(III)) reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CPGNR2"]}, "metabolites": {"cpgn_c": -2.0, "fe2_c": 2.0, "fmnh2_c": -1.0, "fmn_c": 1.0, "h_c": 2.0, "cpgn_un_c": 2.0}, "id": "CPGNR2", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Coprogen(Fe(III)) reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CPGNR3"]}, "metabolites": {"rbflvrd_c": -1.0, "cpgn_c": -2.0, "fe2_c": 2.0, "h_c": 2.0, "cpgn_un_c": 2.0, "ribflv_c": 1.0}, "id": "CPGNR3", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Coprogen unloaded secretion (extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CPGNUtex"]}, "metabolites": {"cpgn_un_p": -1.0, "cpgn_un_e": 1.0, "h_p": -1.0, "h_c": 1.0}, "id": "CPGNUtex", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Coprogen unloaded secretion", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CPGNUtpp"]}, "metabolites": {"cpgn_un_p": 1.0, "cpgn_un_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "CPGNUtpp", "gene_reaction_rule": ""}, {"subsystem": "Transport Inner Membrane", "name": "Coprogen transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CPGNabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "cpgn_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "cpgn_p": -1.0}, "id": "CPGNabcpp", "gene_reaction_rule": "STM0194 and STM0192 and STM0193"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Coprogen Fe-loading reaction (spontaneaous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CPGNexs"]}, "metabolites": {"cpgn_e": 1.0, "cpgn_un_e": -1.0, "fe3_e": -1.0}, "id": "CPGNexs", "gene_reaction_rule": "s0001"}, {"subsystem": "Transport Outer Membrane", "name": "Coprogen transport via ton system (extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CPGNtonex"]}, "metabolites": {"cpgn_e": -1.0, "cpgn_p": 1.0, "h_p": -1.0, "h_c": 1.0}, "id": "CPGNtonex", "gene_reaction_rule": "STM1204 and (STM1737 and STM3158 and STM3159)"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Coproporphyrinogen oxidase (O2 required)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CPPPGO"]}, "metabolites": {"o2_c": -1.0, "h2o_c": 2.0, "pppg9_c": 1.0, "cpppg3_c": -1.0, "h_c": -2.0, "co2_c": 2.0}, "id": "CPPPGO", "gene_reaction_rule": "STM2451"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Oxygen Independent coproporphyrinogen-III oxidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CPPPGO2"]}, "metabolites": {"pppg9_c": 1.0, "dad_5_c": 2.0, "cpppg3_c": -1.0, "met__L_c": 2.0, "amet_c": -2.0, "co2_c": 2.0}, "id": "CPPPGO2", "gene_reaction_rule": "STM4004"}, {"subsystem": "Oxidative Phosphorylation", "name": "Gamma-butyrobetainyl-CoA: carnitine CoA transferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CRNBTCT"]}, "metabolites": {"crn_c": -1.0, "gbbtn_c": 1.0, "crncoa_c": 1.0, "bbtcoa_c": -1.0}, "id": "CRNBTCT", "gene_reaction_rule": "STM0072"}, {"subsystem": "Oxidative Phosphorylation", "name": "Carnitine-CoA Ligase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CRNCAL2"]}, "metabolites": {"crn_c": -1.0, "crncoa_c": 1.0, "atp_c": -1.0, "coa_c": -1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "CRNCAL2", "gene_reaction_rule": "STM0071"}, {"subsystem": "Oxidative Phosphorylation", "name": "Carnitine-CoA racemase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CRNCAR"]}, "metabolites": {"crnDcoa_c": 1.0, "crncoa_c": -1.0}, "id": "CRNCAR", "gene_reaction_rule": "STM0070"}, {"subsystem": "Oxidative Phosphorylation", "name": "Crotonobetainyl-CoA: carnitine CoA transferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CRNCBCT"]}, "metabolites": {"crn_c": -1.0, "ctbtcoa_c": -1.0, "crncoa_c": 1.0, "ctbt_c": 1.0}, "id": "CRNCBCT", "gene_reaction_rule": "STM0072"}, {"subsystem": "Oxidative Phosphorylation", "name": "Carnityl-CoA dehydratse", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CRNCDH"]}, "metabolites": {"ctbtcoa_c": 1.0, "h2o_c": 1.0, "crncoa_c": -1.0}, "id": "CRNCDH", "gene_reaction_rule": "STM0070"}, {"subsystem": "Oxidative Phosphorylation", "name": "D-Carnitine-CoA Ligase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CRNDCAL2"]}, "metabolites": {"atp_c": -1.0, "crnDcoa_c": 1.0, "coa_c": -1.0, "adp_c": 1.0, "pi_c": 1.0, "crn__D_c": -1.0}, "id": "CRNDCAL2", "gene_reaction_rule": "STM0071"}, {"subsystem": "Transport Inner Membrane", "name": "D-carnitine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CRNDabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "crn__D_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "crn__D_c": 1.0}, "id": "CRNDabcpp", "gene_reaction_rule": "STM2809 and STM2810 and STM2811"}, {"subsystem": "Transport Inner Membrane", "name": "D-carnitine outward transport (H+ antiport)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CRNDt2rpp"]}, "metabolites": {"h_c": 1.0, "h_p": -1.0, "crn__D_p": -1.0, "crn__D_c": 1.0}, "id": "CRNDt2rpp", "gene_reaction_rule": "STM4290"}, {"subsystem": "Transport Inner Membrane", "name": "L-carnitine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CRNabcpp"]}, "metabolites": {"crn_c": 1.0, "h2o_c": -1.0, "atp_c": -1.0, "crn_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "CRNabcpp", "gene_reaction_rule": "STM2809 and STM2810 and STM2811"}, {"subsystem": "Transport Inner Membrane", "name": "L-carnitine outward transport (H+ antiport)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CRNt2rpp"]}, "metabolites": {"crn_c": 1.0, "crn_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "CRNt2rpp", "gene_reaction_rule": "STM4290"}, {"subsystem": "Transport Inner Membrane", "name": "Carnitine/butyrobetaine antiporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CRNt7pp"]}, "metabolites": {"crn_c": 1.0, "crn_p": -1.0, "gbbtn_c": -1.0, "gbbtn_p": 1.0}, "id": "CRNt7pp", "gene_reaction_rule": "STM0074"}, {"subsystem": "Transport Inner Membrane", "name": "L-carnitine/D-carnitine antiporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CRNt8pp"]}, "metabolites": {"crn_c": 1.0, "crn_p": -1.0, "crn__D_c": -1.0, "crn__D_p": 1.0}, "id": "CRNt8pp", "gene_reaction_rule": "STM0074"}, {"subsystem": "Transport Outer Membrane Porin", "name": "L-carnitine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CRNtex"]}, "metabolites": {"crn_p": 1.0, "crn_e": -1.0}, "id": "CRNtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Citric Acid Cycle", "name": "Citrate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CS"]}, "metabolites": {"h2o_c": -1.0, "oaa_c": -1.0, "cit_c": 1.0, "coa_c": 1.0, "h_c": 1.0, "accoa_c": -1.0}, "id": "CS", "gene_reaction_rule": "STM0730"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Cytosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CSNtex"]}, "metabolites": {"csn_p": 1.0, "csn_e": -1.0}, "id": "CSNtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Oxidative Phosphorylation", "name": "Crotonobetaine-CoA Ligase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CTBTCAL2"]}, "metabolites": {"atp_c": -1.0, "coa_c": -1.0, "adp_c": 1.0, "ctbtcoa_c": 1.0, "pi_c": 1.0, "ctbt_c": -1.0}, "id": "CTBTCAL2", "gene_reaction_rule": "STM0071"}, {"subsystem": "Transport Inner Membrane", "name": "Crotonobetaine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CTBTabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "ctbt_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "ctbt_c": 1.0}, "id": "CTBTabcpp", "gene_reaction_rule": "STM2809 and STM2810 and STM2811"}, {"subsystem": "Transport Inner Membrane", "name": "Cronobetaine outward transport (H+ antiport)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CTBTt2rpp"]}, "metabolites": {"ctbt_p": -1.0, "h_c": 1.0, "h_p": -1.0, "ctbt_c": 1.0}, "id": "CTBTt2rpp", "gene_reaction_rule": "STM4290"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "CTP synthase (glutamine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CTPS2"]}, "metabolites": {"utp_c": -1.0, "atp_c": -1.0, "glu__L_c": 1.0, "h2o_c": -1.0, "h_c": 2.0, "adp_c": 1.0, "ctp_c": 1.0, "pi_c": 1.0, "gln__L_c": -1.0}, "id": "CTPS2", "gene_reaction_rule": "STM2953"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Cuprous Oxidase (Cu+1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CU1Opp"]}, "metabolites": {"h2o_p": 2.0, "cu2_p": 4.0, "o2_p": -1.0, "cu_p": -4.0, "h_p": -4.0}, "id": "CU1Opp", "gene_reaction_rule": "STM0168"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Copper (Cu +1) ABC transporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CU1abcpp"]}, "metabolites": {"h2o_c": -1.0, "cu_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "cu_p": 1.0}, "id": "CU1abcpp", "gene_reaction_rule": "STM0498"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Gold Au 1 ABC transporter periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AU1abcpp"]}, "metabolites": {"h2o_c": -1.0, "au_p": 1.0, "atp_c": -1.0, "au_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "AU1abcpp", "gene_reaction_rule": "STM0353"}, 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"STM3190"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Copper (Cu+1) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CUtex"]}, "metabolites": {"cu_e": -1.0, "cu_p": 1.0}, "id": "CUtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Unassigned", "name": "Cyanide sulfurtransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYANST"]}, "metabolites": {"h_c": 1.0, "so3_c": 1.0, "tsul_c": -1.0, "cyan_c": -1.0, "tcynt_c": 1.0}, "id": "CYANST", "gene_reaction_rule": "STM3525"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Cyanide sulfurtransferase (periplasmic)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYANSTpp"]}, "metabolites": {"so3_p": 1.0, "tcynt_p": 1.0, "h_p": 1.0, "cyan_p": -1.0, "tsul_p": -1.0}, "id": "CYANSTpp", "gene_reaction_rule": "STM1686"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Cyanide transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CYANtex"]}, "metabolites": {"cyan_e": -1.0, "cyan_p": 1.0}, "id": "CYANtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Cyanate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CYNTtex"]}, "metabolites": {"cynt_p": 1.0, "cynt_e": -1.0}, "id": "CYNTtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Cysteine Metabolism", "name": "Cysteine Desulfhydrase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYSDS", "CYSLDS"]}, "metabolites": {"cys__L_c": -1.0, "h2o_c": -1.0, "pyr_c": 1.0, "nh4_c": 1.0, "h2s_c": 1.0}, "id": "CYSDS_copy1", "gene_reaction_rule": "STM3161"}, {"subsystem": "Transport Outer Membrane Porin", "name": "D-cysteine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CYSDtex"]}, "metabolites": {"cys__D_p": 1.0, "cys__D_e": -1.0}, "id": "CYSDtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Cysteine Metabolism", "name": "Cysteine synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYSS"]}, "metabolites": {"cys__L_c": 1.0, "ac_c": 1.0, "acser_c": -1.0, "h_c": 1.0, "h2s_c": -1.0}, "id": "CYSS", "gene_reaction_rule": "STM2430 or STM2440"}, {"subsystem": "Cysteine Metabolism", "name": "L-cysteine sulfinic acid desulfurase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYSSADS"]}, "metabolites": {"so2_c": 1.0, "ala__L_c": 1.0, "h_c": -2.0, "3sala_c": -1.0}, "id": "CYSSADS", "gene_reaction_rule": "STM2984"}, {"subsystem": "Methionine Metabolism", "name": "Cystathionine b-lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYSTL"]}, "metabolites": {"hcys__L_c": 1.0, "cyst__L_c": -1.0, "pyr_c": 1.0, "nh4_c": 1.0, "h2o_c": -1.0}, "id": "CYSTL", "gene_reaction_rule": "STM1464 or STM3161 or STM1557"}, {"subsystem": "tRNA Charging", "name": "Cysteinyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYSTRS"]}, "metabolites": {"cystrna_c": 1.0, "atp_c": -1.0, "cys__L_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "trnacys_c": -1.0}, "id": "CYSTRS", "gene_reaction_rule": "STM0537"}, {"subsystem": "Transport Inner Membrane", "name": "L-cysteine export via ABC system (cytoplasm to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYSabc2pp"]}, "metabolites": {"cys__L_c": -1.0, "h2o_c": -1.0, "atp_c": -1.0, "cys__L_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "CYSabc2pp", "gene_reaction_rule": "STM0956 and STM0957"}, {"subsystem": "Transport Inner Membrane", "name": "L-cysteine uptake via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYSabcpp"]}, "metabolites": {"cys__L_c": 1.0, "h2o_c": -1.0, "atp_c": -1.0, "cys__L_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "CYSabcpp", "gene_reaction_rule": ""}, {"subsystem": "Transport Inner Membrane", "name": "L cystine uptake via ABC system periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYSIabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "cysi__L_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "cysi__L_p": -1.0, "pi_c": 1.0}, "id": "CYSIabcpp", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "L-cysteine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CYStex"]}, "metabolites": {"cys__L_p": 1.0, "cys__L_e": -1.0}, "id": "CYStex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "L cystine transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CYSItex"]}, "metabolites": {"cysi__L_p": 1.0, "cysi__L_e": -1.0}, "id": "CYSItex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "L-cysteine export via facilitated transport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYStpp"]}, "metabolites": {"cys__L_c": -1.0, "cys__L_p": 1.0}, "id": "CYStpp", "gene_reaction_rule": "STM2645 or STM1517"}, {"subsystem": "Oxidative Phosphorylation", "name": "Cytochrome oxidase bo3 (ubiquinol-8: 4 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYTBO3_4pp"]}, "metabolites": {"o2_c": -0.5, "h2o_c": 1.0, "h_p": 4.0, "q8h2_c": -1.0, "h_c": -4.0, "q8_c": 1.0}, "id": "CYTBO3_4pp", "gene_reaction_rule": "STM0440 and STM0441 and STM0442 and STM0443"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Cytidine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYTD"]}, "metabolites": {"cytd_c": -1.0, "uri_c": 1.0, "h2o_c": -1.0, "nh4_c": 1.0, "h_c": -1.0}, "id": "CYTD", "gene_reaction_rule": "STM2183"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Cytidine hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYTDH"]}, "metabolites": {"cytd_c": -1.0, "h2o_c": -1.0, "csn_c": 1.0, "rib__D_c": 1.0}, "id": "CYTDH", "gene_reaction_rule": "STM0661 or STM0051"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Cytidine kinase (GTP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYTDK2"]}, "metabolites": {"cytd_c": -1.0, "gdp_c": 1.0, "gtp_c": -1.0, "h_c": 1.0, "cmp_c": 1.0}, "id": "CYTDK2", "gene_reaction_rule": "STM2122"}, {"subsystem": "Transport Inner Membrane", "name": "Cytidine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYTDt2pp", "CYTDt2rpp"]}, "metabolites": {"cytd_c": 1.0, "cytd_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "CYTDt2pp_copy1", "gene_reaction_rule": "STM3113 or STM2409"}, {"subsystem": "Transport Inner Membrane", "name": "Cytidine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CYTDt2pp", "CYTDt2rpp"]}, "metabolites": {"cytd_c": 1.0, "cytd_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "CYTDt2pp_copy2", "gene_reaction_rule": "STM2421"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Cytidine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CYTDtex"]}, "metabolites": {"cytd_p": 1.0, "cytd_e": -1.0}, "id": "CYTDtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Cytidylate kinase (CMP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CYTK1"]}, "metabolites": {"cdp_c": 1.0, "adp_c": 1.0, "atp_c": -1.0, "cmp_c": -1.0}, "id": "CYTK1", "gene_reaction_rule": "STM0980"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Cytidylate kinase (dCMP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CYTK2"]}, "metabolites": {"dcmp_c": -1.0, "adp_c": 1.0, "atp_c": -1.0, "dcdp_c": 1.0}, "id": "CYTK2", "gene_reaction_rule": "STM0980"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "D-Amino acid dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAAD"]}, "metabolites": {"h2o_c": -1.0, "pyr_c": 1.0, "fadh2_c": 1.0, "ala__D_c": -1.0, "nh4_c": 1.0, "fad_c": -1.0}, "id": "DAAD", "gene_reaction_rule": "STM1803"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Deoxyadenosine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DADA"]}, "metabolites": {"din_c": 1.0, "dad_2_c": -1.0, "h2o_c": -1.0, "h_c": -1.0, "nh4_c": 1.0}, "id": "DADA", "gene_reaction_rule": "STM1463"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Deoxyadenylate kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DADK"]}, "metabolites": {"dadp_c": 1.0, "damp_c": -1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "DADK", "gene_reaction_rule": "STM0488"}, {"subsystem": "Transport Inner Membrane", "name": "Deoxyadenosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DADNt2pp"]}, "metabolites": {"dad_2_c": 1.0, "dad_2_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "DADNt2pp", "gene_reaction_rule": "STM2409 or STM3113"}, {"subsystem": "Transport Outer Membrane", "name": "Deoxyadenosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DADNtex"]}, "metabolites": {"dad_2_p": 1.0, "dad_2_e": -1.0}, "id": "DADNtex", "gene_reaction_rule": "STM0413"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Diacylglycerol kinase (n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAGK120"]}, "metabolites": {"adp_c": 1.0, "pa120_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "12dgr120_c": -1.0}, "id": "DAGK120", "gene_reaction_rule": "STM4236"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Diacylglycerol kinase (n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAGK140"]}, "metabolites": {"adp_c": 1.0, "pa140_c": 1.0, "12dgr140_c": -1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "DAGK140", "gene_reaction_rule": "STM4236"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Diacylglycerol kinase (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAGK141"]}, "metabolites": {"pa141_c": 1.0, "12dgr141_c": -1.0, "atp_c": -1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "DAGK141", "gene_reaction_rule": "STM4236"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Diacylglycerol kinase (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAGK160"]}, "metabolites": {"pa160_c": 1.0, "12dgr160_c": -1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "DAGK160", "gene_reaction_rule": "STM4236"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Diacylglycerol kinase (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAGK161"]}, "metabolites": {"pa161_c": 1.0, "12dgr161_c": -1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "DAGK161", "gene_reaction_rule": "STM4236"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Diacylglycerol kinase (n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAGK180"]}, "metabolites": {"12dgr180_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pa180_c": 1.0}, "id": "DAGK180", "gene_reaction_rule": "STM4236"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Diacylglycerol kinase (n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAGK181"]}, "metabolites": {"adp_c": 1.0, "12dgr181_c": -1.0, "pa181_c": 1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "DAGK181", "gene_reaction_rule": "STM4236"}, {"subsystem": "Transport Inner Membrane", "name": "D-alanine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DALAt2pp"]}, "metabolites": {"ala__D_c": 1.0, "h_c": 1.0, "h_p": -1.0, "ala__D_p": -1.0}, "id": "DALAt2pp", "gene_reaction_rule": "STM4398"}, {"subsystem": "Transport Outer Membrane Porin", "name": "D-Alanine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DALAtex"]}, "metabolites": {"ala__D_e": -1.0, "ala__D_p": 1.0}, "id": "DALAtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "DAMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DAMPtex"]}, "metabolites": {"damp_p": 1.0, "damp_e": -1.0}, "id": "DAMPtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Diaminopimelate decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAPDC"]}, "metabolites": {"co2_c": 1.0, "lys__L_c": 1.0, "h_c": -1.0, "26dap__M_c": -1.0}, "id": "DAPDC", "gene_reaction_rule": "STM3013"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Diaminopimelate epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DAPE"]}, "metabolites": {"26dap_LL_c": -1.0, "26dap__M_c": 1.0}, "id": "DAPE", "gene_reaction_rule": "STM3947"}, {"subsystem": "Transport Inner Membrane", "name": "M-diaminopimelic acid ABC transport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAPabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "26dap__M_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "26dap__M_p": -1.0}, "id": "DAPabcpp", "gene_reaction_rule": "STM1954"}, {"subsystem": "Transport Outer Membrane Porin", "name": "1,5-Diaminopentane transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DAPtex"]}, "metabolites": {"15dap_p": 1.0, "15dap_e": -1.0}, "id": "DAPtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-diacylglycerol synthetase (n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": 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"lower_bound": 0.0, "notes": {"original_bigg_ids": ["DASYN181"]}, "metabolites": {"ctp_c": -1.0, "pa181_c": -1.0, "ppi_c": 1.0, "h_c": -1.0, "cdpdodec11eg_c": 1.0}, "id": "DASYN181", "gene_reaction_rule": "STM0222"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "DATP amine hydrolysis (spontaneous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DATPHs"]}, "metabolites": {"ditp_c": 1.0, "h2o_c": -1.0, "datp_c": -1.0, "h_c": -1.0, "nh4_c": 1.0}, "id": "DATPHs", "gene_reaction_rule": "s0001"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "3,4-Dihydroxy-2-butanone-4-phosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DB4PS"]}, "metabolites": {"ru5p__D_c": -1.0, "for_c": 1.0, "db4p_c": 1.0, "h_c": 1.0}, "id": "DB4PS", "gene_reaction_rule": "STM3195"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dethiobiotin synthase", "upper_bound": 1000.0, "lower_bound": 0.0, 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"lower_bound": 0.0, "notes": {"original_bigg_ids": ["DCTPD"]}, "metabolites": {"dutp_c": 1.0, "h2o_c": -1.0, "nh4_c": 1.0, "h_c": -1.0, "dctp_c": -1.0}, "id": "DCTPD", "gene_reaction_rule": "STM2121"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Deoxycytidine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DCYTD"]}, "metabolites": {"dcyt_c": -1.0, "h2o_c": -1.0, "nh4_c": 1.0, "duri_c": 1.0, "h_c": -1.0}, "id": "DCYTD", "gene_reaction_rule": "STM2183"}, {"subsystem": "Transport Inner Membrane", "name": "Deoxycytidine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DCYTt2pp"]}, "metabolites": {"dcyt_c": 1.0, "dcyt_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "DCYTt2pp", "gene_reaction_rule": "STM3113 or STM2409"}, {"subsystem": "Transport Outer Membrane", "name": "Deoxycytidine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DCYTtex"]}, "metabolites": {"dcyt_p": 1.0, "dcyt_e": -1.0}, "id": "DCYTtex", "gene_reaction_rule": "STM0413"}, {"subsystem": "Transport Outer Membrane", "name": "Fatty acid (dodecanoate) transport via facilitated irreversible diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DDCAtexi"]}, "metabolites": {"ddca_p": 1.0, "ddca_e": -1.0}, "id": "DDCAtexi", "gene_reaction_rule": "STM2391"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-dehydro-3-deoxygalactonokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DDGALK"]}, "metabolites": {"2dh3dgal6p_c": 1.0, "atp_c": -1.0, "2dh3dgal_c": -1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "DDGALK", "gene_reaction_rule": "STM3829"}, {"subsystem": "Transport Outer Membrane Porin", "name": "2-dehydro-3-deoxy-D-gluconate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DDGLCNtex"]}, "metabolites": {"2ddglcn_p": 1.0, "2ddglcn_e": -1.0}, "id": "DDGLCNtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-dehydro-3-deoxygluconokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DDGLK"]}, "metabolites": {"h_c": 1.0, "2ddglcn_c": -1.0, "2ddg6p_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "DDGLK", "gene_reaction_rule": "STM3612"}, {"subsystem": "Tyrosine Tryptophan and Phenylalanine Metabolism", "name": "3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DDPA"]}, "metabolites": {"pep_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0, "2dda7p_c": 1.0, "e4p_c": -1.0}, "id": "DDPA", "gene_reaction_rule": "STM2670 or STM0760 or STM1347"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Deoxyguanylate kinase (dGMP:ATP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DGK1"]}, "metabolites": {"dgdp_c": 1.0, "dgmp_c": -1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "DGK1", "gene_reaction_rule": "STM3740"}, {"subsystem": "Transport Outer Membrane Porin", "name": "DGMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DGMPtex"]}, "metabolites": {"dgmp_e": -1.0, "dgmp_p": 1.0}, "id": "DGMPtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "Deoxyguanosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DGSNt2pp"]}, "metabolites": {"dgsn_c": 1.0, "dgsn_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "DGSNt2pp", "gene_reaction_rule": "STM3113"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Deoxyguanosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DGSNtex"]}, "metabolites": {"dgsn_p": 1.0, "dgsn_e": -1.0}, "id": "DGSNtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Valine Leucine and Isoleucine Metabolism", "name": "Dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHAD1"]}, "metabolites": {"h2o_c": 1.0, "23dhmb_c": -1.0, "3mob_c": 1.0}, "id": "DHAD1", "gene_reaction_rule": "STM3904"}, {"subsystem": "Valine Leucine and Isoleucine Metabolism", "name": "Dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHAD2"]}, "metabolites": {"23dhmp_c": -1.0, "3mop_c": 1.0, "h2o_c": 1.0}, "id": "DHAD2", "gene_reaction_rule": "STM3904"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Dihydroxyacetone transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHAtex"]}, "metabolites": {"dha_e": -1.0, "dha_p": 1.0}, "id": "DHAtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "Dihydroxyacetone transport via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHAtpp"]}, "metabolites": {"dha_p": -1.0, "dha_c": 1.0}, "id": "DHAtpp", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHBD"]}, "metabolites": {"23dhb_c": 1.0, "nadh_c": 1.0, "23ddhb_c": -1.0, "nad_c": -1.0, "h_c": 1.0}, "id": "DHBD", "gene_reaction_rule": "STM0598"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2,3-dihydroxybenzoate adenylate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHBS"]}, "metabolites": {"23dhb_c": -1.0, "23dhba_c": 1.0, "ppi_c": 1.0, "h_c": -1.0, "atp_c": -1.0}, "id": "DHBS", "gene_reaction_rule": "STM0596"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Dihydrodipicolinate reductase (NADPH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHDPRy"]}, "metabolites": {"23dhdp_c": -1.0, "thdp_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0}, "id": "DHDPRy", "gene_reaction_rule": "STM0064"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Dihydrodipicolinate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHDPS"]}, "metabolites": {"aspsa_c": -1.0, "h2o_c": 2.0, "23dhdp_c": 1.0, "pyr_c": -1.0, "h_c": 1.0}, "id": "DHDPS", "gene_reaction_rule": "STM2489"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydrofolate reductase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHFR"]}, "metabolites": {"thf_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "dhf_c": -1.0, "h_c": -1.0}, "id": "DHFR", "gene_reaction_rule": "STM0087"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydrofolate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHFS"]}, "metabolites": {"dhf_c": 1.0, "atp_c": -1.0, "glu__L_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "dhpt_c": -1.0, "pi_c": 1.0}, "id": "DHFS", "gene_reaction_rule": "STM2365"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "1,4-dihydroxy-2-naphthoate octaprenyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHNAOT4"]}, "metabolites": {"co2_c": 1.0, "octdp_c": -1.0, "ppi_c": 1.0, "2dmmql8_c": 1.0, "h_c": -1.0, "dhna_c": -1.0}, "id": "DHNAOT4", "gene_reaction_rule": "STM4090"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydroneopterin aldolase reversible", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHNPA2"]}, "metabolites": {"dhnpt_c": -1.0, "gcald_c": 1.0, "6hmhpt_c": 1.0}, "id": "DHNPA2r", "gene_reaction_rule": "STM3206"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Dihydoorotic acid dehydrogenase (quinone8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHORD2"]}, "metabolites": {"q8h2_c": 1.0, "dhor__S_c": -1.0, "q8_c": -1.0, "orot_c": 1.0}, "id": "DHORD2", "gene_reaction_rule": "STM1058"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Dihydroorotic acid (menaquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHORD5"]}, "metabolites": {"dhor__S_c": -1.0, "mqn8_c": -1.0, "mql8_c": 1.0, "orot_c": 1.0}, "id": "DHORD5", "gene_reaction_rule": "STM1058"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Dihydroorotase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHORTS"]}, "metabolites": {"cbasp_c": 1.0, "h2o_c": -1.0, "dhor__S_c": -1.0, "h_c": 1.0}, "id": "DHORTS", "gene_reaction_rule": "STM1163"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Diaminohydroxyphosphoribosylaminopryrimidine deaminase (25drapp)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPPDA2"]}, "metabolites": {"5apru_c": 1.0, "h2o_c": -1.0, "nh4_c": 1.0, "25drapp_c": -1.0, "h_c": -1.0}, "id": "DHPPDA2", "gene_reaction_rule": "STM0416"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydropteroate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPS2"]}, "metabolites": {"dhpt_c": 1.0, "6hmhptpp_c": -1.0, "ppi_c": 1.0, "4abz_c": -1.0}, "id": "DHPS2", "gene_reaction_rule": "STM3295"}, {"subsystem": "Methionine Metabolism", "name": "4,5-dihydroxy-2,3-pentanedione cyclization (spontaneous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPTDCs"]}, "metabolites": {"h2o_c": 1.0, "hmfurn_c": 1.0, "dhptd_c": -1.0}, "id": "DHPTDCs", "gene_reaction_rule": "s0001"}, {"subsystem": "Tyrosine Tryptophan and Phenylalanine Metabolism", "name": "3-dehydroquinate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHQS"]}, "metabolites": {"3dhq_c": 1.0, "pi_c": 1.0, "2dda7p_c": -1.0}, "id": "DHQS", "gene_reaction_rule": "STM3486"}, {"subsystem": "Tyrosine Tryptophan and Phenylalanine Metabolism", "name": "3-dehydroquinate dehydratase, irreversible", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHQTi"]}, "metabolites": {"3dhsk_c": 1.0, "h2o_c": 1.0, "3dhq_c": -1.0}, "id": "DHQTi", "gene_reaction_rule": "STM1358"}, {"subsystem": "Transport Outer Membrane Porin", "name": "DIMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DIMPtex"]}, "metabolites": {"dimp_p": 1.0, "dimp_e": -1.0}, "id": "DIMPtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "Deoxyinosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DINSt2pp"]}, "metabolites": {"din_p": -1.0, "din_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "DINSt2pp", "gene_reaction_rule": "STM3113"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Deoxyinosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DINStex"]}, "metabolites": {"din_p": 1.0, "din_e": -1.0}, "id": "DINStex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2,5-diketo-D-gluconate reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DKGLCNR1"]}, "metabolites": {"25dkglcn_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "2dhguln_c": 1.0}, "id": "DKGLCNR1", "gene_reaction_rule": "STM3165 or STM0255"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2,5-diketo-D-gluconate reductase (NADH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DKGLCNR2x"]}, "metabolites": {"25dkglcn_c": -1.0, "nadh_c": -1.0, "5dglcn_c": 1.0, "h_c": -1.0, "nad_c": 1.0}, "id": "DKGLCNR2x", "gene_reaction_rule": "STM3646"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2,5-diketo-D-gluconate reductase (NADPH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DKGLCNR2y"]}, "metabolites": {"nadph_c": -1.0, "25dkglcn_c": -1.0, "5dglcn_c": 1.0, "nadp_c": 1.0, "h_c": -1.0}, "id": "DKGLCNR2y", "gene_reaction_rule": "STM3646"}, {"subsystem": "Arginine and Proline Metabolism", "name": "2,3-diketo-5-methylthio-1-phosphopentane degradation reaction", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DKMPPD"]}, "metabolites": {"dkmpp_c": -1.0, "h2o_c": -1.0, "o2_c": -1.0, "2kmb_c": 1.0, "h_c": 2.0, "for_c": 1.0, "pi_c": 1.0}, "id": "DKMPPD", "gene_reaction_rule": ""}, {"subsystem": "Arginine and Proline Metabolism", "name": "2,3-diketo-5-methylthio-1-phosphopentane degradation reaction", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DKMPPD3"]}, "metabolites": {"dkmpp_c": -1.0, "h2o_c": -3.0, "pi_c": 1.0, "nad_c": -2.0, "2kmb_c": 1.0, "h_c": 4.0, "for_c": 1.0, "nadh_c": 2.0}, "id": "DKMPPD3", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dimethylallyltranstransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DMATT"]}, "metabolites": {"dmpp_c": -1.0, "ppi_c": 1.0, "ipdp_c": -1.0, "grdp_c": 1.0}, "id": "DMATT", "gene_reaction_rule": "STM0423"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (dmpp)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DMPPS"]}, "metabolites": {"h2o_c": 1.0, "dmpp_c": 1.0, "h2mb4p_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "nadh_c": -1.0}, "id": "DMPPS", "gene_reaction_rule": "STM0049"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "3-Dimethylubiquinonol 3-methyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DMQMT"]}, "metabolites": {"amet_c": -1.0, "2omhmbl_c": -1.0, "ahcys_c": 1.0, "h_c": 1.0, "q8h2_c": 1.0}, "id": "DMQMT", "gene_reaction_rule": "STM2276"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Dimethyl sulfoxide transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DMSOtex"]}, "metabolites": {"dmso_p": 1.0, "dmso_e": -1.0}, "id": "DMSOtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Dimethyl sulfide transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DMStex"]}, "metabolites": {"dms_p": 1.0, "dms_e": -1.0}, "id": "DMStex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Intracellular demand", "name": "Sink needed to allow 4-hydroxy-benzoate to leave system", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DM_4HBA"]}, "metabolites": {"4hba_c": -1.0}, "id": "DM_4hba_c", "gene_reaction_rule": ""}, {"subsystem": "Intracellular demand", "name": "Sink needed to allow 5'-deoxyribose to leave system", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DM_5DRIB"]}, "metabolites": {"5drib_c": -1.0}, "id": "DM_5drib_c", "gene_reaction_rule": ""}, {"subsystem": "Intracellular demand", "name": "Sink needed to allow 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{"original_bigg_ids": ["DPCOAK"]}, "metabolites": {"dpcoa_c": -1.0, "coa_c": 1.0, "adp_c": 1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "DPCOAK", "gene_reaction_rule": "STM0140"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Deoxyribose-phosphate aldolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DRPA"]}, "metabolites": {"acald_c": 1.0, "g3p_c": 1.0, "2dr5p_c": -1.0}, "id": "DRPA", "gene_reaction_rule": "STM4567"}, {"subsystem": "Unassigned", "name": "DsbA protein reoxidation reaction (aerobic)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DSBAO1"]}, "metabolites": {"q8h2_c": 1.0, "dsbaox_p": 1.0, "q8_c": -1.0, "dsbard_p": -1.0}, "id": "DSBAO1", "gene_reaction_rule": "STM3997 and STM1807"}, {"subsystem": "Unassigned", "name": "DsbA protein reoxidation reaction (anaerobic)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DSBAO2"]}, "metabolites": {"dsbaox_p": 1.0, "mqn8_c": -1.0, 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{"subsystem": "Glycine and Serine Metabolism", "name": "D-serine dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DSERDHr"]}, "metabolites": {"2amsa_c": 1.0, "ser__D_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "h_c": 1.0}, "id": "DSERDHr", "gene_reaction_rule": "STM1511"}, {"subsystem": "Transport Inner Membrane", "name": "D-serine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DSERt2pp"]}, "metabolites": {"ser__D_p": -1.0, "ser__D_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "DSERt2pp", "gene_reaction_rule": "STM4398"}, {"subsystem": "Transport Outer Membrane Porin", "name": "D-serine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DSERtex"]}, "metabolites": {"ser__D_p": 1.0, "ser__D_e": -1.0}, "id": "DSERtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "DTMP kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DTMPK"]}, "metabolites": {"dtmp_c": -1.0, "dtdp_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "DTMPK", "gene_reaction_rule": "STM1200"}, {"subsystem": "Transport Outer Membrane Porin", "name": "DTMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DTMPtex"]}, "metabolites": {"dtmp_p": 1.0, "dtmp_e": -1.0}, "id": "DTMPtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "DUMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DUMPtex"]}, "metabolites": {"dump_e": -1.0, "dump_p": 1.0}, "id": "DUMPtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Nucleotide Salvage 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transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DURItex"]}, "metabolites": {"duri_e": -1.0, "duri_p": 1.0}, "id": "DURItex", "gene_reaction_rule": "STM0413"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "DUTP diphosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DUTPDP"]}, "metabolites": {"h2o_c": -1.0, "ppi_c": 1.0, "dutp_c": -1.0, "dump_c": 1.0, "h_c": 1.0}, "id": "DUTPDP", "gene_reaction_rule": "STM3731"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "1-deoxy-D-xylulose reductoisomerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DXPRIi"]}, "metabolites": {"2me4p_c": 1.0, "dxyl5p_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0}, "id": "DXPRIi", "gene_reaction_rule": "STM0220"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "1-deoxy-D-xylulose 5-phosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DXPS"]}, "metabolites": {"pyr_c": -1.0, "dxyl5p_c": 1.0, "co2_c": 1.0, "h_c": -1.0, "g3p_c": -1.0}, "id": "DXPS", "gene_reaction_rule": "STM0422"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "1-Deoxy-D-xylulose kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DXYLK"]}, "metabolites": {"dxyl5p_c": 1.0, "dxyl_c": -1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "DXYLK", "gene_reaction_rule": "STM3660"}, {"subsystem": "Transport Inner Membrane", "name": "D-lactate transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["D_LACt2pp"]}, "metabolites": {"lac__D_c": 1.0, "h_c": 1.0, "h_p": -1.0, "lac__D_p": -1.0}, "id": "D_LACt2pp", "gene_reaction_rule": "STM3692"}, {"subsystem": "Transport Outer Membrane Porin", "name": "D-lactate transport via diffusion (extracellular to periplasm)", 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"Enoyl-[acyl-carrier-protein] reductase (NADPH) (n-C10:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EAR100y"]}, "metabolites": {"tdec2eACP_c": -1.0, "dcaACP_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0}, "id": "EAR100y", "gene_reaction_rule": "STM1700"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Enoyl-[acyl-carrier-protein] reductase (NADH) (n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EAR120x"]}, "metabolites": {"tddec2eACP_c": -1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "ddcaACP_c": 1.0}, "id": "EAR120x", "gene_reaction_rule": "STM1700"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Enoyl-[acyl-carrier-protein] reductase (NADPH) (n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EAR120y"]}, "metabolites": {"nadp_c": 1.0, "tddec2eACP_c": -1.0, "nadph_c": -1.0, "h_c": -1.0, "ddcaACP_c": 1.0}, "id": "EAR120y", "gene_reaction_rule": "STM1700"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Enoyl-[acyl-carrier-protein] reductase (NADH) (n-C12:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EAR121x"]}, "metabolites": {"nadh_c": -1.0, "t3c5ddeceACP_c": -1.0, "cddec5eACP_c": 1.0, "nad_c": 1.0, "h_c": -1.0}, "id": "EAR121x", "gene_reaction_rule": "STM1700"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Enoyl-[acyl-carrier-protein] reductase (NADPH) (n-C12:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EAR121y"]}, "metabolites": {"t3c5ddeceACP_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "cddec5eACP_c": 1.0}, "id": "EAR121y", "gene_reaction_rule": "STM1700"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Enoyl-[acyl-carrier-protein] reductase (NADH) (n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EAR140x"]}, "metabolites": {"myrsACP_c": 1.0, "nadh_c": -1.0, "tmrs2eACP_c": -1.0, 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"STM1700"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Enoyl-[acyl-carrier-protein] reductase (NADPH) (n-C6:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EAR60y"]}, "metabolites": {"thex2eACP_c": -1.0, "hexACP_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "nadp_c": 1.0}, "id": "EAR60y", "gene_reaction_rule": "STM1700"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Enoyl-[acyl-carrier-protein] reductase (NADH) (n-C8:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EAR80x"]}, "metabolites": {"nad_c": 1.0, "nadh_c": -1.0, "toct2eACP_c": -1.0, "ocACP_c": 1.0, "h_c": -1.0}, "id": "EAR80x", "gene_reaction_rule": "STM1700"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Enoyl-[acyl-carrier-protein] reductase (NADPH) (n-C8:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EAR80y"]}, "metabolites": {"ocACP_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "toct2eACP_c": -1.0}, "id": "EAR80y", "gene_reaction_rule": "STM1700"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Enterobacterial common antigen (x4) core oligosaccharide lipid A transport (periplasm to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ECA4COLIPAtex"]}, "metabolites": {"eca4colipa_e": 1.0, "eca4colipa_p": -1.0}, "id": "ECA4COLIPAtex", "gene_reaction_rule": ""}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Enterobacterial common antigen (x4) O-antigen ligase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ECA4OALpp"]}, "metabolites": {"eca4colipa_p": 1.0, "eca4und_p": -1.0, "colipa_p": -1.0, "udcpdp_p": 1.0, "h_p": 1.0}, "id": "ECA4OALpp", "gene_reaction_rule": "STM3713"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Enterobacterial common antigen polymerase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ECAP1pp"]}, "metabolites": {"eca2und_p": 1.0, "unagamuf_p": -2.0, "udcpdp_p": 1.0, "h_p": 1.0}, "id": "ECAP1pp", "gene_reaction_rule": "STM3928 and STM3919"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Enterobacterial common antigen polymerase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ECAP2pp"]}, "metabolites": {"eca2und_p": -1.0, "unagamuf_p": -1.0, "eca3und_p": 1.0, "udcpdp_p": 1.0, "h_p": 1.0}, "id": "ECAP2pp", "gene_reaction_rule": "STM3928 and STM3919"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Enterobacterial common antigen polymerase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ECAP3pp"]}, "metabolites": {"unagamuf_p": -1.0, "eca4und_p": 1.0, "eca3und_p": -1.0, "udcpdp_p": 1.0, "h_p": 1.0}, "id": "ECAP3pp", "gene_reaction_rule": "STM3928 and STM3919"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Enterobacterial common antigen transferase (flippase, cytoplasm to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ECAtpp"]}, "metabolites": {"unagamuf_p": 1.0, "unagamuf_c": -1.0}, "id": "ECAtpp", "gene_reaction_rule": "STM3926"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH1"]}, "metabolites": {"h2o_c": 1.0, "3hbcoa_c": -1.0, "b2coa_c": 1.0}, "id": "ECOAH1", "gene_reaction_rule": "STM3983 or STM2388"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxyhexanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH2"]}, "metabolites": {"3hhcoa_c": -1.0, "h2o_c": 1.0, "hx2coa_c": 1.0}, "id": "ECOAH2", "gene_reaction_rule": "STM3983 or STM2388"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxyoctanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH3"]}, "metabolites": {"oc2coa_c": 1.0, "h2o_c": 1.0, "3hocoa_c": -1.0}, "id": "ECOAH3", "gene_reaction_rule": "STM2388 or STM3983"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxydecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH4"]}, "metabolites": {"3hdcoa_c": -1.0, "h2o_c": 1.0, "dc2coa_c": 1.0}, "id": "ECOAH4", "gene_reaction_rule": "STM3983 or STM2388"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxydodecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH5"]}, "metabolites": {"h2o_c": 1.0, "3hddcoa_c": -1.0, "dd2coa_c": 1.0}, "id": "ECOAH5", "gene_reaction_rule": "STM3983 or STM2388"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxytetradecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH6"]}, "metabolites": {"h2o_c": 1.0, "3htdcoa_c": -1.0, "td2coa_c": 1.0}, "id": "ECOAH6", "gene_reaction_rule": "STM3983 or STM2388"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxyhexadecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH7"]}, "metabolites": {"h2o_c": 1.0, "hdd2coa_c": 1.0, "3hhdcoa_c": -1.0}, "id": "ECOAH7", "gene_reaction_rule": "STM3983 or STM2388"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxyoctadecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH8"]}, "metabolites": {"3hodcoa_c": -1.0, "od2coa_c": 1.0, "h2o_c": 1.0}, "id": "ECOAH8", "gene_reaction_rule": "STM3983 or STM2388"}, {"subsystem": "Pentose Phosphate Pathway", "name": "2-dehydro-3-deoxy-phosphogluconate aldolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EDA"]}, "metabolites": {"pyr_c": 1.0, "g3p_c": 1.0, "2ddg6p_c": -1.0}, "id": "EDA", "gene_reaction_rule": "STM1884"}, {"subsystem": "Pentose Phosphate Pathway", "name": "6-phosphogluconate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EDD"]}, "metabolites": {"6pgc_c": -1.0, "h2o_c": 1.0, "2ddg6p_c": 1.0}, "id": "EDD", "gene_reaction_rule": "STM1885"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Endotoxin Synthesis (lauroyl transferase)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EDTXS1"]}, "metabolites": {"kdo2lipid4_c": -1.0, "kdo2lipid4L_c": 1.0, "ACP_c": 1.0, "ddcaACP_c": -1.0}, "id": "EDTXS1", "gene_reaction_rule": "STM1155"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Endotoxin Synthesis (myristoyl transferase)", "upper_bound": 1000.0, 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"FACOAE181", "gene_reaction_rule": "STM0464"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Fatty-acid-CoA thioesterase (hexanoate)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FACOAE60"]}, "metabolites": {"h2o_c": -1.0, "coa_c": 1.0, "hxa_c": 1.0, "hxcoa_c": -1.0, "h_c": 1.0}, "id": "FACOAE60", "gene_reaction_rule": "STM0464"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Fatty-acid-CoA thioesterase (octanoate)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FACOAE80"]}, "metabolites": {"occoa_c": -1.0, "h2o_c": -1.0, "coa_c": 1.0, "h_c": 1.0, "octa_c": 1.0}, "id": "FACOAE80", "gene_reaction_rule": "STM0464"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Fatty-acid-CoA ligase (decanoate transport via vectoral Co-A coupling)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FACOAL100t2pp"]}, "metabolites": {"dca_p": -1.0, "atp_c": -1.0, "h_p": -1.0, "ppi_c": 1.0, "coa_c": 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"metabolites": {"fecrm_e": -1.0, "h_c": 1.0, "h_p": -1.0, "fecrm_p": 1.0}, "id": "FECRMtonex", "gene_reaction_rule": "STM0191 and (STM1737 and STM3158 and STM3159)"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Fe-enterobactin transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FEENTERabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "feenter_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "feenter_c": 1.0}, "id": "FEENTERabcpp", "gene_reaction_rule": "STM0594 and STM0590 and STM0592 and STM0591"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Enterobactin Fe(III) binding (spontaneous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FEENTERexs"]}, "metabolites": {"enter_e": -1.0, "feenter_e": 1.0, "fe3_e": -1.0}, "id": "FEENTERexs", "gene_reaction_rule": "s0001"}, {"subsystem": "Transport Outer Membrane", "name": "Fe-enterobactin transport via ton 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"name": "Ferroxamine (minus Fe3) secretion (to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FEOXAMUtpp"]}, "metabolites": {"feoxam_un_p": 1.0, "feoxam_un_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "FEOXAMUtpp", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Ferroxamine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FEOXAMabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "feoxam_c": 1.0, "feoxam_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "FEOXAMabcpp", "gene_reaction_rule": "STM0194 and STM0192 and STM0193"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Ferroxamine Fe3-loading reaction (spontaneous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FEOXAMexs"]}, "metabolites": {"feoxam_e": 1.0, "feoxam_un_e": -1.0, "fe3_e": -1.0}, "id": "FEOXAMexs", "gene_reaction_rule": "s0001"}, {"subsystem": "Transport Outer Membrane", "name": "Ferroxamine transport via ton system (extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FEOXAMtonex"]}, "metabolites": {"feoxam_p": 1.0, "feoxam_e": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "FEOXAMtonex", "gene_reaction_rule": "STM0191 and (STM1737 and STM3158 and STM3159)"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Ferroxidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FEROpp"]}, "metabolites": {"h2o_p": 2.0, "o2_p": -1.0, "fe2_p": -4.0, "fe3_p": 4.0, "h_p": -4.0}, "id": "FEROpp", "gene_reaction_rule": "STM0168"}, {"subsystem": "Pyruvate Metabolism", "name": "Formate-hydrogen lyase", "upper_bound": 0.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FHL"]}, "metabolites": {"co2_c": 1.0, "h2_c": 1.0, "h_c": -1.0, "for_c": -1.0}, "id": "FHL", "gene_reaction_rule": "STM4285 and (STM2847 and STM2848 and STM2849 and STM2850 and STM2851 and STM2852)"}, {"subsystem": "Unassigned", "name": "Flavodoxin reductase (NADPH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FLDR"]}, "metabolites": {"fldox_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "fldrd_c": 1.0}, "id": "FLDR", "gene_reaction_rule": "(STM0694 and STM4084) or (STM3045 and STM4084)"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Flavin reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FLVR"]}, "metabolites": {"rbflvrd_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "ribflv_c": -1.0}, "id": "FLVR", "gene_reaction_rule": "(STM2947 and STM2948) or STM3979"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Flavin reductase (NAD)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FLVRx"]}, "metabolites": {"rbflvrd_c": 1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "ribflv_c": -1.0}, "id": "FLVRx", "gene_reaction_rule": "STM3979"}, {"subsystem": "tRNA Charging", "name": "Methionyl-tRNA formyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FMETTRS"]}, "metabolites": {"h_c": 1.0, "10fthf_c": -1.0, "mettrna_c": -1.0, "thf_c": 1.0, "fmettrna_c": 1.0}, "id": "FMETTRS", "gene_reaction_rule": "STM3407"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "FMN adenylyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FMNAT"]}, "metabolites": {"fad_c": 1.0, "ppi_c": 1.0, "fmn_c": -1.0, "h_c": -1.0, "atp_c": -1.0}, "id": "FMNAT", "gene_reaction_rule": "STM0045"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "FMN reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FMNRx"]}, "metabolites": {"fmnh2_c": 1.0, "nadh_c": -1.0, "fmn_c": -1.0, "h_c": -1.0, "nad_c": 1.0}, "id": "FMNRx", "gene_reaction_rule": "STM3979"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "FMN reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FMNRx2"]}, "metabolites": {"fmnh2_c": 1.0, "fmn_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0}, "id": "FMNRx2", "gene_reaction_rule": "(STM2947 and STM2948) or STM3979"}, {"subsystem": "Transport Inner Membrane", "name": "Formate transport via proton symport (uptake only, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FORt2pp"]}, "metabolites": {"h_p": -1.0, "h_c": 1.0, "for_c": 1.0, "for_p": -1.0}, "id": "FORt2pp", "gene_reaction_rule": "STM0974"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Formate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FORtex"]}, "metabolites": {"for_e": -1.0, "for_p": 1.0}, "id": "FORtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "Formate transport via diffusion (cytoplasm to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FORtppi"]}, "metabolites": {"for_p": 1.0, "for_c": -1.0}, "id": "FORtppi", "gene_reaction_rule": "STM0974"}, {"subsystem": "Citric Acid Cycle", "name": "Fumarate reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FRD2"]}, "metabolites": {"succ_c": 1.0, "fum_c": -1.0, "mqn8_c": 1.0, "mql8_c": -1.0}, "id": "FRD2", "gene_reaction_rule": "STM4340 and STM4341 and STM4342 and STM4343"}, {"subsystem": "Citric Acid Cycle", "name": "Fumarate reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FRD3"]}, "metabolites": {"succ_c": 1.0, "fum_c": -1.0, "2dmmq8_c": 1.0, "2dmmql8_c": -1.0}, "id": "FRD3", "gene_reaction_rule": "STM4340 and STM4341 and STM4342 and STM4343"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Fructose-1-phosphate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FRUK"]}, "metabolites": {"adp_c": 1.0, "f1p_c": -1.0, "fdp_c": 1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "FRUK", "gene_reaction_rule": "STM2205"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Fructoselysine transporter via diffusion (extracellular)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FRULYStex"]}, "metabolites": {"frulys_p": 1.0, "frulys_e": -1.0}, "id": "FRULYStex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "D-fructuronate transport via diffusion (extracellular)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FRUURtex"]}, "metabolites": {"fruur_e": -1.0, "fruur_p": 1.0}, "id": "FRUURtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "Fructose transport via PEP:Pyr PTS (f6p generating) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FRUpts2pp"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "fru_p": -1.0, "f6p_c": 1.0}, "id": "FRUpts2pp", "gene_reaction_rule": "STM1830 and STM1831 and STM1832 and STM2431 and STM2432"}, {"subsystem": "Transport Inner Membrane", "name": "D-fructose transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FRUptspp"]}, "metabolites": {"pep_c": -1.0, "f1p_c": 1.0, "pyr_c": 1.0, "fru_p": -1.0}, "id": "FRUptspp", "gene_reaction_rule": "STM2204 and STM2206 and STM2431 and STM2432"}, {"subsystem": "Transport Outer Membrane Porin", "name": "D-fructose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FRUtex"]}, "metabolites": {"fru_e": -1.0, "fru_p": 1.0}, "id": "FRUtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Folate Metabolism", "name": "Formyltetrahydrofolate deformylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FTHFD"]}, "metabolites": {"h_c": 1.0, "h2o_c": -1.0, "thf_c": 1.0, "for_c": 1.0, "10fthf_c": -1.0}, "id": "FTHFD", "gene_reaction_rule": "STM1756"}, {"subsystem": "Transport Outer Membrane Porin", "name": "L-fucose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FUCtex"]}, "metabolites": {"fuc__L_p": 1.0, "fuc__L_e": -1.0}, "id": "FUCtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "L-fucose transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FUCtpp"]}, "metabolites": {"fuc__L_p": -1.0, "fuc__L_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "FUCtpp", "gene_reaction_rule": "STM2975"}, {"subsystem": "Citric Acid Cycle", "name": "Fumarase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FUM"]}, "metabolites": {"h2o_c": -1.0, "fum_c": -1.0, "mal__L_c": 1.0}, "id": "FUM", "gene_reaction_rule": "STM1468 or STM4300 or STM1469 or (STM0761 and STM0762)"}, {"subsystem": "Transport Inner Membrane", "name": "Fumarate transport via proton symport (2 H) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FUMt2_2pp"]}, "metabolites": {"fum_p": -1.0, "fum_c": 1.0, "h_c": 2.0, "h_p": -2.0}, "id": "FUMt2_2pp", "gene_reaction_rule": "STM3614"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Fumarate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FUMtex"]}, "metabolites": {"fum_p": 1.0, "fum_e": -1.0}, "id": "FUMtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Glucosamine-1-phosphate N-acetyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G1PACT"]}, "metabolites": {"gam1p_c": -1.0, "coa_c": 1.0, "h_c": 1.0, "accoa_c": -1.0, "acgam1p_c": 1.0}, "id": "G1PACT", "gene_reaction_rule": "STM3862"}, {"subsystem": "GlycolysisGluconeogenesis", "name": "Glucose-1-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G1PPpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "glc__D_p": 1.0, "g1p_p": -1.0}, "id": "G1PPpp", "gene_reaction_rule": "STM1117"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Glucose-1-phosphate thymidylyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G1PTT"]}, "metabolites": {"dtdpglu_c": 1.0, "ppi_c": 1.0, "dttp_c": -1.0, "h_c": -1.0, "g1p_c": -1.0}, "id": "G1PTT", "gene_reaction_rule": "STM3923 or STM2095"}, {"subsystem": "Transport Outer Membrane Porin", "name": "D-glucose 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1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PAT120"]}, "metabolites": {"1ddecg3p_c": 1.0, "glyc3p_c": -1.0, "ACP_c": 1.0, "ddcaACP_c": -1.0}, "id": "G3PAT120", "gene_reaction_rule": "STM4235"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerol-3-phosphate acyltransferase (C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PAT140"]}, "metabolites": {"1tdecg3p_c": 1.0, "glyc3p_c": -1.0, "ACP_c": 1.0, "myrsACP_c": -1.0}, "id": "G3PAT140", "gene_reaction_rule": "STM4235"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerol-3-phosphate acyltransferase (C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PAT141"]}, "metabolites": {"tdeACP_c": -1.0, "glyc3p_c": -1.0, "ACP_c": 1.0, "1tdec7eg3p_c": 1.0}, "id": "G3PAT141", "gene_reaction_rule": "STM4235"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerol-3-phosphate acyltransferase (C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PAT160"]}, "metabolites": {"glyc3p_c": -1.0, "ACP_c": 1.0, "1hdecg3p_c": 1.0, "palmACP_c": -1.0}, "id": "G3PAT160", "gene_reaction_rule": "STM4235"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerol-3-phosphate acyltransferase (C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PAT161"]}, "metabolites": {"1hdec9eg3p_c": 1.0, "glyc3p_c": -1.0, "ACP_c": 1.0, "hdeACP_c": -1.0}, "id": "G3PAT161", "gene_reaction_rule": "STM4235"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerol-3-phosphate acyltransferase (C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PAT180"]}, "metabolites": {"ocdcaACP_c": -1.0, "ACP_c": 1.0, "glyc3p_c": -1.0, "1odecg3p_c": 1.0}, "id": "G3PAT180", "gene_reaction_rule": "STM4235"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerol-3-phosphate acyltransferase (C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PAT181"]}, "metabolites": {"1odec11eg3p_c": 1.0, "glyc3p_c": -1.0, "ACP_c": 1.0, "octeACP_c": -1.0}, "id": "G3PAT181", "gene_reaction_rule": "STM4235"}, {"subsystem": "Transport Inner Membrane", "name": "Sn-glycerol-3-phosphocholine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PCabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "g3pc_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "g3pc_c": 1.0}, "id": "G3PCabcpp", "gene_reaction_rule": "STM3556 and STM3557 and STM3554 and STM3555"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Glycero-3-phosphocholine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G3PCtex"]}, "metabolites": {"g3pc_e": -1.0, "g3pc_p": 1.0}, "id": "G3PCtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glycerol-3-phosphate dehydrogenase (NADP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G3PD2"]}, "metabolites": {"nadph_c": 1.0, "glyc3p_c": -1.0, "dhap_c": 1.0, "nadp_c": -1.0, "h_c": 1.0}, "id": "G3PD2", "gene_reaction_rule": "STM3700"}, {"subsystem": "Oxidative Phosphorylation", "name": "Glycerol-3-phosphate dehydrogenase (ubiquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PD5"]}, "metabolites": {"q8h2_c": 1.0, "glyc3p_c": -1.0, "dhap_c": 1.0, "q8_c": -1.0}, "id": "G3PD5", "gene_reaction_rule": "(STM2284 and STM2285 and STM2286) or STM3526"}, {"subsystem": "Oxidative Phosphorylation", "name": "Glycerol-3-phosphate dehydrogenase (menaquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PD6"]}, "metabolites": {"glyc3p_c": -1.0, "dhap_c": 1.0, "mqn8_c": -1.0, "mql8_c": 1.0}, "id": "G3PD6", "gene_reaction_rule": "STM2284 and STM2285 and STM2286"}, {"subsystem": "Oxidative Phosphorylation", "name": "Glycerol-3-phosphate dehydrogenase (demethylmenaquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PD7"]}, "metabolites": {"glyc3p_c": -1.0, "dhap_c": 1.0, "2dmmq8_c": -1.0, "2dmmql8_c": 1.0}, "id": "G3PD7", "gene_reaction_rule": "STM2284 and STM2285 and STM2286"}, {"subsystem": "Transport Inner Membrane", "name": "Sn-glycerol-3-phosphoethanolamine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PEabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "g3pe_c": 1.0, "g3pe_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "G3PEabcpp", "gene_reaction_rule": "STM3556 and STM3557 and STM3554 and STM3555"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Glycero-3-phosphoethanolamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G3PEtex"]}, "metabolites": {"g3pe_e": -1.0, "g3pe_p": 1.0}, "id": "G3PEtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "Sn-glycerol-3-phosphoglycerol transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PGabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "g3pg_p": -1.0, "g3pg_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "G3PGabcpp", "gene_reaction_rule": "STM3556 and STM3557 and STM3554 and STM3555"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Glycerophoglycerol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G3PGtex"]}, "metabolites": {"g3pg_p": 1.0, "g3pg_e": -1.0}, "id": "G3PGtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "Sn-glycerol-3-phosphoethanolamine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PIabcpp"]}, "metabolites": {"g3pi_p": -1.0, "h2o_c": -1.0, "atp_c": -1.0, "g3pi_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "G3PIabcpp", "gene_reaction_rule": "STM3556 and STM3557 and STM3554 and STM3555"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Glycero-3-phospho-1-inositol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G3PItex"]}, "metabolites": {"g3pi_p": 1.0, "g3pi_e": -1.0}, "id": "G3PItex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "Sn-glycerol-3-phosphoserine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PSabcpp"]}, "metabolites": {"h2o_c": -1.0, "g3ps_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "g3ps_p": -1.0, "pi_c": 1.0}, "id": "G3PSabcpp", "gene_reaction_rule": "STM3556 and STM3557 and STM3554 and STM3555"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Glycerophosphserine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G3PStex"]}, "metabolites": {"g3ps_e": -1.0, "g3ps_p": 1.0}, "id": "G3PStex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glycerol-3-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PT"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "glyc3p_c": -1.0, "glyc_c": 1.0}, "id": "G3PT", "gene_reaction_rule": "STM0840 or STM0842"}, {"subsystem": "Arginine and Proline Metabolism", "name": "L-glutamate 5-semialdehyde dehydratase (spontaneous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G5SADs"]}, "metabolites": {"1pyr5c_c": 1.0, "glu5sa_c": -1.0, "h2o_c": 1.0, "h_c": 1.0}, "id": "G5SADs", "gene_reaction_rule": "s0001"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Glutamate-5-semialdehyde dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G5SD"]}, "metabolites": {"glu5sa_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "pi_c": 1.0, "glu5p_c": -1.0}, "id": "G5SD", "gene_reaction_rule": "STM0322"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glucosamine-6-phosphate deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G6PDA"]}, "metabolites": {"h2o_c": -1.0, "nh4_c": 1.0, "gam6p_c": -1.0, "f6p_c": 1.0}, "id": "G6PDA", "gene_reaction_rule": "STM0684"}, {"subsystem": "Pentose Phosphate Pathway", "name": "Glucose 6-phosphate dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G6PDH2r"]}, "metabolites": {"nadph_c": 1.0, "g6p_c": -1.0, "6pgl_c": 1.0, "nadp_c": -1.0, "h_c": 1.0}, "id": "G6PDH2r", "gene_reaction_rule": "STM1886"}, {"subsystem": "GlycolysisGluconeogenesis", "name": "Glucose-6-phosphate phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G6PP"]}, "metabolites": {"glc__D_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0, "g6p_c": -1.0}, "id": "G6PP", "gene_reaction_rule": "STM0840 or STM0842"}, {"subsystem": "Transport Inner Membrane", "name": "Glucose-6-phosphate transport via phosphate antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G6Pt6_2pp"]}, "metabolites": {"pi_p": 2.0, "g6p_p": -1.0, "g6p_c": 1.0, "pi_c": -2.0}, "id": "G6Pt6_2pp", "gene_reaction_rule": "STM3787"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Glucose 6-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G6Ptex"]}, "metabolites": {"g6p_p": 1.0, "g6p_e": -1.0}, "id": "G6Ptex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Alternate Carbon Metabolism", "name": "D-galactose 1-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GAL1PPpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "gal_p": 1.0, "gal1p_p": -1.0}, "id": "GAL1PPpp", "gene_reaction_rule": "STM1117"}, {"subsystem": "Transport Outer Membrane Porin", "name": "D-galactose 1-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GAL1Ptex"]}, "metabolites": {"gal1p_e": -1.0, "gal1p_p": 1.0}, "id": "GAL1Ptex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Beta D-galactose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALBDtex"]}, "metabolites": {"gal_bD_e": -1.0, "gal_bD_p": 1.0}, "id": "GALBDtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "L-galactonate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALCTNLtex"]}, "metabolites": {"galctn__L_p": 1.0, "galctn__L_e": -1.0}, "id": "GALCTNLtex", "gene_reaction_rule": "STM2267 or STM1473 or STM0999 or STM0320"}, {"subsystem": "Transport Inner Membrane", "name": "D-galactonate transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALCTNt2pp"]}, "metabolites": {"galctn__D_c": 1.0, "galctn__D_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GALCTNt2pp", "gene_reaction_rule": "STM3827"}, {"subsystem": "Transport Outer Membrane Porin", "name": "D-galactonate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALCTNtex"]}, "metabolites": {"galctn__D_p": 1.0, "galctn__D_e": -1.0}, "id": "GALCTNtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "D-galactarte transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALCTt2rpp"]}, "metabolites": {"h_p": -1.0, "galct__D_c": 1.0, "galct__D_p": -1.0, "h_c": 1.0}, "id": "GALCTt2rpp", "gene_reaction_rule": "STM2962"}, {"subsystem": "Transport Outer Membrane Porin", "name": "D-galactarte transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALCTtex"]}, "metabolites": {"galct__D_e": -1.0, "galct__D_p": 1.0}, "id": "GALCTtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Galactokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALKr"]}, "metabolites": {"gal_c": -1.0, "atp_c": -1.0, "adp_c": 1.0, "gal1p_c": 1.0, "h_c": 1.0}, "id": "GALKr", "gene_reaction_rule": "STM0774 or STM2101"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Aldose-1-epimerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALM2pp"]}, "metabolites": {"gal_p": 1.0, "gal_bD_p": -1.0}, "id": "GALM2pp", "gene_reaction_rule": "STM0773"}, {"subsystem": "Alternate Carbon Metabolism", "name": "A-galactosidase (melibiose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALS3"]}, "metabolites": {"glc__D_c": 1.0, "h2o_c": -1.0, "gal_c": 1.0, "melib_c": -1.0}, "id": "GALS3", "gene_reaction_rule": "STM4298"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Galactosyltransferase I (LPS core synthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALT1"]}, "metabolites": {"gagicolipa_c": 1.0, "udp_c": 1.0, "udpg_c": -1.0, "h_c": 1.0, "gicolipa_c": -1.0}, "id": "GALT1", "gene_reaction_rule": "STM3719"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Galactitol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALTtex"]}, "metabolites": {"galt_e": -1.0, "galt_p": 1.0}, "id": "GALTtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "D-galacturonate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALURt2rpp"]}, "metabolites": {"galur_c": 1.0, "h_c": 1.0, "h_p": -1.0, "galur_p": -1.0}, "id": "GALURt2rpp", "gene_reaction_rule": "STM3134"}, {"subsystem": "Transport Outer Membrane Porin", "name": "D-galacturonate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALURtex"]}, "metabolites": {"galur_e": -1.0, "galur_p": 1.0}, "id": "GALURtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UTP-glucose-1-phosphate uridylyltransferase (irreversible)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALUi"]}, "metabolites": {"utp_c": -1.0, "ppi_c": 1.0, "udpg_c": 1.0, "h_c": -1.0, "g1p_c": -1.0}, "id": "GALUi", "gene_reaction_rule": "STM1752 and STM2098"}, {"subsystem": "Transport Inner Membrane", "name": "D-galactose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "gal_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "gal_p": -1.0, "pi_c": 1.0}, "id": "GALabcpp", "gene_reaction_rule": "STM2189 and STM2190 and STM2188"}, {"subsystem": "Transport Inner Membrane", "name": "D-galactose transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALt2pp"]}, "metabolites": {"gal_p": -1.0, "gal_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GALt2pp", "gene_reaction_rule": "STM3091"}, {"subsystem": "Transport Outer Membrane Porin", "name": "D-galactose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALtex"]}, "metabolites": {"gal_p": 1.0, "gal_e": -1.0}, "id": "GALtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "D-Glucosamine 6-phosphate transport via phosphate antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GAM6Pt6_2pp"]}, "metabolites": {"pi_p": 2.0, "gam6p_p": -1.0, "gam6p_c": 1.0, "pi_c": -2.0}, "id": "GAM6Pt6_2pp", "gene_reaction_rule": "STM3787"}, {"subsystem": "Transport Outer Membrane Porin", "name": "D-glucosamine 6-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GAMAN6Ptex"]}, "metabolites": {"gam6p_p": 1.0, "gam6p_e": -1.0}, "id": "GAMAN6Ptex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "D-glucosamine transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GAMptspp"]}, "metabolites": {"pep_c": -1.0, "gam_p": -1.0, "gam6p_c": 1.0, "pyr_c": 1.0}, "id": "GAMptspp", "gene_reaction_rule": "STM1830 and STM1831 and STM1832 and STM2431 and STM2432"}, {"subsystem": "Transport Outer Membrane Porin", "name": "D-glucosamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GAMtex"]}, "metabolites": {"gam_p": 1.0, "gam_e": -1.0}, "id": "GAMtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "GlycolysisGluconeogenesis", "name": "Glyceraldehyde-3-phosphate dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GAPD"]}, "metabolites": {"nadh_c": 1.0, "13dpg_c": 1.0, "g3p_c": -1.0, "h_c": 1.0, "nad_c": -1.0, "pi_c": -1.0}, "id": "GAPD", "gene_reaction_rule": "STM1290"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylglycinamide formyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GARFT"]}, "metabolites": {"gar_c": -1.0, "fgam_c": 1.0, "thf_c": 1.0, "h_c": 1.0, "10fthf_c": -1.0}, "id": "GARFT", "gene_reaction_rule": "STM2500"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "GAR transformylase-T", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GART"]}, "metabolites": {"for_c": -1.0, "atp_c": -1.0, "fgam_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "gar_c": -1.0, "pi_c": 1.0}, "id": "GART", "gene_reaction_rule": "STM1883"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Gamma-butyrobetaine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GBBTNtex"]}, "metabolites": {"gbbtn_e": -1.0, "gbbtn_p": 1.0}, "id": "GBBTNtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "GDP-4-dehydro-6-deoxy-D-mannose epimerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GDMANE"]}, "metabolites": {"gdpddman_c": -1.0, "gdpofuc_c": 1.0}, "id": "GDMANE", "gene_reaction_rule": "STM2108"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "GDP diphosphokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GDPDPK"]}, "metabolites": {"ppgpp_c": 1.0, "gdp_c": -1.0, "amp_c": 1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "GDPDPK", "gene_reaction_rule": "STM2956 or STM3742"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "GDP-mannose mannosyl hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GDPMNH"]}, "metabolites": {"h2o_c": -1.0, "man_c": 1.0, "gdp_c": 1.0, "h_c": 1.0, "gdpmann_c": -1.0}, "id": "GDPMNH", "gene_reaction_rule": "STM2107"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "GDP-mannose phyrophosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GDPMNP"]}, "metabolites": {"man1p_c": 1.0, "gmp_c": 1.0, "h_c": 2.0, "h2o_c": -1.0, "gdpmann_c": -1.0}, "id": "GDPMNP", "gene_reaction_rule": "STM2477"}, {"subsystem": "Transport Outer Membrane Porin", "name": "GDP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GDPtex"]}, "metabolites": {"gdp_e": -1.0, "gdp_p": 1.0}, "id": "GDPtex", "gene_reaction_rule": "STM0320 or STM1473 or STM2267 or STM0999"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Glutamine-fructose-6-phosphate transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GF6PTA"]}, "metabolites": {"gam6p_c": 1.0, "gln__L_c": -1.0, "glu__L_c": 1.0, "f6p_c": -1.0}, "id": "GF6PTA", "gene_reaction_rule": "STM3861"}, {"subsystem": "Glycine and Serine Metabolism", "name": "Glycine hydroxymethyltransferase, reversible", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GHMT2r"]}, "metabolites": {"h2o_c": 1.0, "ser__L_c": -1.0, "thf_c": -1.0, "mlthf_c": 1.0, "gly_c": 1.0}, "id": "GHMT2r", "gene_reaction_rule": "STM2555"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Guanylate kinase (GMP:ATP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GK1"]}, "metabolites": {"gmp_c": -1.0, "gdp_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "GK1", "gene_reaction_rule": "STM3740"}, {"subsystem": "GlycolysisGluconeogenesis", "name": "1,4-alpha-glucan branching enzyme (glycogen -> bglycogen)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLBRAN2"]}, "metabolites": {"bglycogen_c": 1.0, "glycogen_c": -1.0}, "id": "GLBRAN2", "gene_reaction_rule": "STM3538"}, {"subsystem": "Alternate Carbon Metabolism", "name": "D-glucose O-acetyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCATr"]}, "metabolites": {"glc__D_c": -1.0, "acglc__D_c": 1.0, "coa_c": 1.0, "accoa_c": -1.0}, "id": "GLCATr", "gene_reaction_rule": "STM0472"}, {"subsystem": "Oxidative Phosphorylation", "name": "Glucose dehydrogenase (ubiquinone-8 as acceptor) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCDpp"]}, "metabolites": {"glcn_p": 1.0, "h_p": 1.0, "q8h2_c": 1.0, "glc__D_p": -1.0, "h2o_p": -1.0, "q8_c": -1.0}, "id": "GLCDpp", "gene_reaction_rule": "STM0861 or STM0169"}, {"subsystem": "Transport Inner Membrane", "name": "D-gluconate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCNt2rpp"]}, "metabolites": {"glcn_p": -1.0, "glcn_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GLCNt2rpp", "gene_reaction_rule": "STM3512 or STM4482 or STM3541"}, {"subsystem": "Transport Outer Membrane Porin", "name": "D-gluconate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCNtex"]}, "metabolites": {"glcn_p": 1.0, "glcn_e": -1.0}, "id": "GLCNtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "GlycolysisGluconeogenesis", "name": "Glycogen phosphorylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCP"]}, "metabolites": {"pi_c": -1.0, "glycogen_c": -1.0, "g1p_c": 1.0}, "id": "GLCP", "gene_reaction_rule": "STM3534 or STM3514"}, {"subsystem": "GlycolysisGluconeogenesis", "name": "Glycogen phosphorylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCP2"]}, "metabolites": {"bglycogen_c": -1.0, "pi_c": -1.0, "g1p_c": 1.0}, "id": "GLCP2", "gene_reaction_rule": "STM3514 or STM3534"}, {"subsystem": "Alternate Carbon Metabolism", "name": "5-dehydro-4-deoxyglucarate aldolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCRAL"]}, "metabolites": {"pyr_c": 1.0, "5dh4dglc_c": -1.0, "2h3oppan_c": 1.0}, "id": "GLCRAL", "gene_reaction_rule": "STM3249"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glucarate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCRD"]}, "metabolites": {"h2o_c": 1.0, "5dh4dglc_c": 1.0, "glcr_c": -1.0}, "id": "GLCRD", "gene_reaction_rule": "STM2960 or STM2961"}, {"subsystem": "Transport Inner Membrane", "name": "D-glucarate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCRt2rpp"]}, "metabolites": {"h_p": -1.0, "glcr_p": -1.0, "glcr_c": 1.0, "h_c": 1.0}, "id": "GLCRt2rpp", "gene_reaction_rule": "STM2962"}, {"subsystem": "Transport Outer Membrane Porin", "name": "D-glucarate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCRtex"]}, "metabolites": {"glcr_e": -1.0, "glcr_p": 1.0}, "id": "GLCRtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "GlycolysisGluconeogenesis", "name": "Glycogen synthase (ADPGlc)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCS1"]}, "metabolites": {"adpglc_c": -1.0, "glycogen_c": 1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "GLCS1", "gene_reaction_rule": "STM3535"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Glucosyltransferase I (LPS core synthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCTR1"]}, "metabolites": {"icolipa_c": -1.0, "udp_c": 1.0, "udpg_c": -1.0, "h_c": 1.0, "gicolipa_c": 1.0}, "id": "GLCTR1", "gene_reaction_rule": "STM3722"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Glucosyltransferase II (LPS core synthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCTR2"]}, "metabolites": {"ggagicolipa_c": 1.0, "gagicolipa_c": -1.0, "udp_c": 1.0, "udpg_c": -1.0, "h_c": 1.0}, "id": "GLCTR2", "gene_reaction_rule": "STM3718"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Glucosyltransferase III (LPS core synthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCTR3"]}, "metabolites": {"gggagicolipa_c": 1.0, "udp_c": 1.0, "udpg_c": -1.0, "ggagicolipa_c": -1.0, "h_c": 1.0}, "id": "GLCTR3", "gene_reaction_rule": "STM3717"}, {"subsystem": "Transport Outer Membrane Porin", "name": "D-glucuronate 1-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCUR1Ptex"]}, "metabolites": {"glcur1p_p": 1.0, "glcur1p_e": -1.0}, "id": "GLCUR1Ptex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "D-glucuronate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCURt2rpp"]}, "metabolites": {"glcur_c": 1.0, "h_c": 1.0, "h_p": -1.0, "glcur_p": -1.0}, "id": "GLCURt2rpp", "gene_reaction_rule": "STM3134 or STM0161"}, {"subsystem": "Transport Outer Membrane Porin", "name": "D-glucuronat transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCURtex"]}, "metabolites": {"glcur_e": -1.0, "glcur_p": 1.0}, "id": "GLCURtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "D-glucose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "glc__D_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "glc__D_c": 1.0, "pi_c": 1.0}, "id": "GLCabcpp", "gene_reaction_rule": "STM2189 and STM2190 and STM2188"}, {"subsystem": "Transport Inner Membrane", "name": "D-glucose transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCptspp"]}, "metabolites": {"pep_c": -1.0, "g6p_c": 1.0, "glc__D_p": -1.0, "pyr_c": 1.0}, "id": "GLCptspp", "gene_reaction_rule": "(STM2433 and STM1203 and STM2431 and STM2432) or (STM1830 and STM1831 and STM1832 and STM2431 and STM2432) or (STM2433 and STM1465 and STM2431 and STM2432)"}, {"subsystem": "Transport Inner Membrane", "name": "D-glucose transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCt2pp"]}, "metabolites": {"glc__D_c": 1.0, "glc__D_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GLCt2pp", "gene_reaction_rule": "STM3091"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Glucose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCtex", "GLCtexi"]}, "metabolites": {"glc__D_p": 1.0, "glc__D_e": -1.0}, "id": "GLCtex_copy1", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane", "name": "Glucose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCtex", "GLCtexi"]}, "metabolites": {"glc__D_p": 1.0, "glc__D_e": -1.0}, "id": "GLCtex_copy2", "gene_reaction_rule": "STM4231"}, {"subsystem": "GlycolysisGluconeogenesis", "name": "Glycogen debranching enzyme (bglycogen -> glycogen)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLDBRAN2"]}, "metabolites": {"bglycogen_c": -1.0, "glycogen_c": 1.0}, "id": "GLDBRAN2", "gene_reaction_rule": "STM3537"}, {"subsystem": "GlycolysisGluconeogenesis", "name": "Glucose-1-phosphate adenylyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLGC"]}, "metabolites": {"h_c": -1.0, "ppi_c": 1.0, "adpglc_c": 1.0, "atp_c": -1.0, "g1p_c": -1.0}, "id": "GLGC", "gene_reaction_rule": "STM3536"}, {"subsystem": "Glutamate metabolism", "name": "Glutamine synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLNS"]}, "metabolites": {"atp_c": -1.0, "glu__L_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "nh4_c": -1.0, "gln__L_c": 1.0}, "id": "GLNS", "gene_reaction_rule": "STM4007"}, {"subsystem": "tRNA Charging", "name": "Glutaminyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLNTRS"]}, "metabolites": {"glntrna_c": 1.0, "atp_c": -1.0, "trnagln_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "gln__L_c": -1.0}, "id": "GLNTRS", "gene_reaction_rule": "STM0686"}, {"subsystem": "Transport Inner Membrane", "name": "L-glutamine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLNabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "gln__L_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "gln__L_c": 1.0}, "id": "GLNabcpp", "gene_reaction_rule": "STM0830 and STM0829 and STM0828"}, {"subsystem": "Transport Outer Membrane Porin", "name": "L-glutamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLNtex"]}, "metabolites": {"gln__L_e": -1.0, "gln__L_p": 1.0}, "id": "GLNtex", "gene_reaction_rule": "STM0999 or STM1473 or STM2267 or STM0320"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Glutamate 5-kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLU5K"]}, "metabolites": {"glu__L_c": -1.0, "glu5p_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "GLU5K", "gene_reaction_rule": "STM0321"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Gamma-glutamylcysteine synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUCYS"]}, "metabolites": {"cys__L_c": -1.0, "glucys_c": 1.0, "atp_c": -1.0, "glu__L_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "GLUCYS", "gene_reaction_rule": "STM2818"}, {"subsystem": "Glutamate Metabolism", "name": "Glutamate dehydrogenase (NADP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLUDy"]}, "metabolites": {"akg_c": 1.0, "h2o_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "glu__L_c": -1.0, "h_c": 1.0, "nh4_c": 1.0}, "id": "GLUDy", "gene_reaction_rule": "STM1299"}, {"subsystem": "Glutamate Metabolism", "name": "Glutaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUN"]}, "metabolites": {"h2o_c": -1.0, "glu__L_c": 1.0, "nh4_c": 1.0, "gln__L_c": -1.0}, "id": "GLUN", "gene_reaction_rule": "STM1525"}, {"subsystem": "Glutamate Metabolism", "name": "Glutaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUNpp"]}, "metabolites": {"glu__L_p": 1.0, "gln__L_p": -1.0, "nh4_p": 1.0, "h2o_p": -1.0}, "id": "GLUNpp", "gene_reaction_rule": "STM3106"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Glutamine phosphoribosyldiphosphate amidotransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUPRT"]}, "metabolites": {"pram_c": 1.0, "h2o_c": -1.0, "ppi_c": 1.0, "glu__L_c": 1.0, "prpp_c": -1.0, "gln__L_c": -1.0}, "id": "GLUPRT", "gene_reaction_rule": "STM2362"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Glutamate racemase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLUR"]}, "metabolites": {"glu__D_c": -1.0, "glu__L_c": 1.0}, "id": "GLUR", "gene_reaction_rule": "STM4131"}, {"subsystem": "Glutamate metabolism", "name": "Glutamate synthase (NADPH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUSy"]}, "metabolites": {"akg_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "glu__L_c": 2.0, "h_c": -1.0, "gln__L_c": -1.0}, "id": "GLUSy", "gene_reaction_rule": "STM3330 and STM3331"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Glutamyl-tRNA reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUTRR"]}, "metabolites": {"nadp_c": 1.0, "nadph_c": -1.0, "glu1sa_c": 1.0, "trnaglu_c": 1.0, "h_c": -1.0, "glutrna_c": -1.0}, "id": "GLUTRR", "gene_reaction_rule": "STM1777"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Glutamyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUTRS"]}, "metabolites": {"atp_c": -1.0, "glu__L_c": -1.0, 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{"original_bigg_ids": ["GLUt4pp"]}, "metabolites": {"na1_p": -1.0, "glu__L_p": -1.0, "glu__L_c": 1.0, "na1_c": 1.0}, "id": "GLUt4pp", "gene_reaction_rule": "STM3746"}, {"subsystem": "Transport Outer Membrane Porin", "name": "L-glutamate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLUtex"]}, "metabolites": {"glu__L_p": 1.0, "glu__L_e": -1.0}, "id": "GLUtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Glyoxylate Metabolism", "name": "Glyoxalate carboligase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLXCL"]}, "metabolites": {"co2_c": 1.0, "glx_c": -2.0, "h_c": -1.0, "2h3oppan_c": 1.0}, "id": "GLXCL", "gene_reaction_rule": "STM0517"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Glyceraldehyde transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYALDtex"]}, "metabolites": {"glyald_e": -1.0, "glyald_p": 1.0}, "id": "GLYALDtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "Glyceraldehyde facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYALDtpp"]}, "metabolites": {"glyald_c": 1.0, "glyald_p": -1.0}, "id": "GLYALDtpp", "gene_reaction_rule": "STM4087"}, {"subsystem": "Glycine and Serine Metabolism", "name": "Glycine C-acetyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYAT"]}, "metabolites": {"coa_c": 1.0, "gly_c": -1.0, "accoa_c": -1.0, "2aobut_c": 1.0}, "id": "GLYAT", "gene_reaction_rule": "STM3709"}, {"subsystem": "Transport Inner Membrane", "name": "Glycine betaine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYBabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "glyb_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "glyb_p": -1.0}, "id": "GLYBabcpp", "gene_reaction_rule": "STM2162 and STM2163 and STM2164 and STM2165"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Glycine betaine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYBtex", "GLYBt6ex"]}, "metabolites": {"glyb_e": -1.0, "glyb_p": 1.0}, "id": "GLYBtex_copy1", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Glycerol-2-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYC2Ptex"]}, "metabolites": {"glyc2p_e": -1.0, "glyc2p_p": 1.0}, "id": "GLYC2Ptex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "Sn-Glycerol 3-phosphate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYC3Pabcpp"]}, "metabolites": {"glyc3p_c": 1.0, "atp_c": -1.0, "h2o_c": -1.0, "glyc3p_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "GLYC3Pabcpp", "gene_reaction_rule": "STM3556 and STM3557 and STM3554 and STM3555"}, {"subsystem": "Transport Inner Membrane", "name": "Glycerol-3-phosphate : phosphate antiporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYC3Pt6pp"]}, "metabolites": {"pi_p": 1.0, "glyc3p_p": -1.0, "glyc3p_c": 1.0, "pi_c": -1.0}, "id": "GLYC3Pt6pp", "gene_reaction_rule": "STM2283"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Glycerol-3-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYC3Ptex"]}, "metabolites": {"glyc3p_p": 1.0, "glyc3p_e": -1.0}, "id": "GLYC3Ptex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "D-glycerate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYCAt2rpp"]}, "metabolites": {"glyc__R_c": 1.0, "h_c": 1.0, "h_p": -1.0, "glyc__R_p": -1.0}, "id": "GLYCAt2rpp", "gene_reaction_rule": "STM2962"}, {"subsystem": "Transport Outer Membrane Porin", "name": "D-glycerate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYCAtex"]}, "metabolites": {"glyc__R_e": -1.0, "glyc__R_p": 1.0}, "id": "GLYCAtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glycerol dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCDx"]}, "metabolites": {"nad_c": -1.0, "nadh_c": 1.0, "h_c": 1.0, "dha_c": 1.0, "glyc_c": -1.0}, "id": "GLYCDx", "gene_reaction_rule": "STM4108 or STM3529"}, {"subsystem": "Glyoxylate Metabolism", "name": "Glycerate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCK"]}, "metabolites": {"h_c": 1.0, "glyc__R_c": -1.0, "adp_c": 1.0, "atp_c": -1.0, "3pg_c": 1.0}, "id": "GLYCK", "gene_reaction_rule": "STM2959 or STM2492 or STM3247 or STM0525"}, {"subsystem": "Glycine and Serine Metabolism", "name": "Glycerate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCK2"]}, "metabolites": {"2pg_c": 1.0, "glyc__R_c": -1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "GLYCK2", "gene_reaction_rule": "STM3247"}, {"subsystem": "Folate Metabolism", "name": "Glycine Cleavage System", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCL"]}, "metabolites": {"co2_c": 1.0, "mlthf_c": 1.0, "gly_c": -1.0, "thf_c": -1.0, "nad_c": -1.0, "nadh_c": 1.0, "nh4_c": 1.0}, "id": "GLYCL", "gene_reaction_rule": "STM3054 and STM3053 and STM3055 and STM0154"}, {"subsystem": "Glyoxylate Metabolism", "name": "Glycolate dehydrogenase (NAD)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCLTDx"]}, "metabolites": {"glyclt_c": 1.0, "nadh_c": -1.0, "glx_c": -1.0, "h_c": -1.0, "nad_c": 1.0}, "id": "GLYCLTDx", "gene_reaction_rule": "STM3646 or STM1135"}, {"subsystem": "Glyoxylate Metabolism", "name": "Glycolate dehydrogenase (NADP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCLTDy"]}, "metabolites": {"glx_c": -1.0, "glyclt_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "nadp_c": 1.0}, "id": "GLYCLTDy", "gene_reaction_rule": "STM3646 or STM1135"}, {"subsystem": "Transport Inner Membrane", "name": "Glycolate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYCLTt2rpp"]}, "metabolites": {"glyclt_p": -1.0, "glyclt_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GLYCLTt2rpp", "gene_reaction_rule": "STM3692"}, {"subsystem": "Transport Inner Membrane", "name": "Glycolate transport via sodium symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCLTt4pp"]}, "metabolites": {"glyclt_p": -1.0, "na1_p": -1.0, "glyclt_c": 1.0, "na1_c": 1.0}, "id": "GLYCLTt4pp", "gene_reaction_rule": "STM4273"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Glycolate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYCLTtex"]}, "metabolites": {"glyclt_p": 1.0, "glyclt_e": -1.0}, "id": "GLYCLTtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glycolate oxidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCTO2"]}, "metabolites": {"q8h2_c": 1.0, "glyclt_c": -1.0, "glx_c": 1.0, "q8_c": -1.0}, "id": "GLYCTO2", "gene_reaction_rule": "STM1620"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glycolate oxidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCTO3"]}, "metabolites": {"glx_c": 1.0, "glyclt_c": -1.0, "mqn8_c": -1.0, "mql8_c": 1.0}, "id": "GLYCTO3", "gene_reaction_rule": "STM1620"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glycolate oxidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCTO4"]}, "metabolites": {"glyclt_c": -1.0, "glx_c": 1.0, "2dmmq8_c": -1.0, "2dmmql8_c": 1.0}, "id": "GLYCTO4", "gene_reaction_rule": "STM1620"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Glycerol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYCtex"]}, "metabolites": {"glyc_e": -1.0, "glyc_p": 1.0}, "id": "GLYCtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "Glycerol transport via channel (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYCtpp"]}, "metabolites": {"glyc_c": -1.0, "glyc_p": 1.0}, "id": "GLYCtpp", "gene_reaction_rule": "s0001 or STM4087"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glycerol kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYK"]}, "metabolites": {"h_c": 1.0, "glyc3p_c": 1.0, "atp_c": -1.0, "adp_c": 1.0, "glyc_c": -1.0}, "id": "GLYK", "gene_reaction_rule": "STM4086"}, {"subsystem": "Methylglyoxal Metabolism", "name": "Hydroxyacylglutathione hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYOX"]}, "metabolites": {"gthrd_c": 1.0, "h2o_c": -1.0, "lac__D_c": 1.0, "h_c": 1.0, "lgt__S_c": -1.0}, "id": "GLYOX", "gene_reaction_rule": "STM0261"}, {"subsystem": "Methylglyoxal Metabolism", "name": "Glyoxalase III", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYOX3"]}, "metabolites": {"h2o_c": -1.0, "lac__D_c": 1.0, "h_c": 1.0, "mthgxl_c": -1.0}, "id": "GLYOX3", "gene_reaction_rule": ""}, {"subsystem": "tRNA Charging", "name": "Glycyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYTRS"]}, "metabolites": {"glytrna_c": 1.0, "atp_c": -1.0, "ppi_c": 1.0, "trnagly_c": -1.0, "amp_c": 1.0, "gly_c": -1.0}, "id": "GLYTRS", "gene_reaction_rule": "STM3655 and STM3656"}, {"subsystem": "Transport Inner Membrane", "name": "Glycine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYt2pp"]}, "metabolites": {"h_p": -1.0, "gly_c": 1.0, "gly_p": -1.0, "h_c": 1.0}, "id": "GLYt2pp", "gene_reaction_rule": "STM4398"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Glycine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYtex"]}, "metabolites": {"gly_e": -1.0, "gly_p": 1.0}, "id": "GLYtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "GDP-D-mannose dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GMAND"]}, "metabolites": {"h2o_c": 1.0, "gdpddman_c": 1.0, "gdpmann_c": -1.0}, "id": "GMAND", "gene_reaction_rule": "STM2109"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "D-glycero-D-manno-hepose 1-phosphate adenyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GMHEPAT"]}, "metabolites": {"ppi_c": 1.0, "gmhep1p_c": -1.0, "adphep_DD_c": 1.0, "h_c": -1.0, "atp_c": -1.0}, "id": "GMHEPAT", "gene_reaction_rule": "STM3200"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "D-glycero-D-manno-heptose 7-phosphate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GMHEPK"]}, "metabolites": {"gmhep7p_c": -1.0, "gmhep17bp_c": 1.0, "atp_c": -1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "GMHEPK", "gene_reaction_rule": "STM3200"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GMHEPPA"]}, "metabolites": {"h2o_c": -1.0, "gmhep1p_c": 1.0, "gmhep17bp_c": -1.0, "pi_c": 1.0}, "id": "GMHEPPA", "gene_reaction_rule": "STM0248"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "GMP reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GMPR"]}, "metabolites": {"nadp_c": 1.0, "nadph_c": -1.0, "nh4_c": 1.0, "gmp_c": -1.0, "h_c": -2.0, "imp_c": 1.0}, "id": "GMPR", "gene_reaction_rule": "STM0141"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "GMP synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GMPS2"]}, "metabolites": {"xmp_c": -1.0, "h2o_c": -1.0, "gmp_c": 1.0, "atp_c": -1.0, "glu__L_c": 1.0, "amp_c": 1.0, "gln__L_c": -1.0, "ppi_c": 1.0, "h_c": 2.0}, "id": "GMPS2", "gene_reaction_rule": "STM2510"}, {"subsystem": "Transport Outer Membrane Porin", "name": "GMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GMPtex"]}, "metabolites": {"gmp_p": 1.0, "gmp_e": -1.0}, "id": "GMPtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Pentose Phosphate Pathway", "name": "Phosphogluconate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GND"]}, "metabolites": {"6pgc_c": -1.0, "nadph_c": 1.0, "co2_c": 1.0, "nadp_c": -1.0, "ru5p__D_c": 1.0}, "id": "GND", "gene_reaction_rule": "STM2081"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Gluconokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GNK"]}, "metabolites": {"6pgc_c": 1.0, "glcn_c": -1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "GNK", "gene_reaction_rule": "STM4485 or STM3542"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "GDP-4-oxo-L-fucose reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GOFUCR"]}, "metabolites": {"gdpfuc_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "gdpofuc_c": -1.0}, "id": "GOFUCR", "gene_reaction_rule": "STM2108"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GPDDA1"]}, "metabolites": {"chol_c": 1.0, "h2o_c": -1.0, "glyc3p_c": 1.0, "g3pc_c": -1.0, "h_c": 1.0}, "id": "GPDDA1", "gene_reaction_rule": "STM3553"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GPDDA1pp"]}, "metabolites": {"glyc3p_p": 1.0, "chol_p": 1.0, "g3pc_p": -1.0, "h_p": 1.0, "h2o_p": -1.0}, "id": "GPDDA1pp", "gene_reaction_rule": "STM2282"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerophosphodiester phosphodiesterase (Glycerophosphoethanolamine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GPDDA2"]}, "metabolites": {"h2o_c": -1.0, "glyc3p_c": 1.0, "h_c": 1.0, "etha_c": 1.0, "g3pe_c": -1.0}, "id": "GPDDA2", "gene_reaction_rule": "STM3553"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerophosphodiester phosphodiesterase (Glycerophosphoethanolamine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GPDDA2pp"]}, "metabolites": {"glyc3p_p": 1.0, "g3pe_p": -1.0, "etha_p": 1.0, "h_p": 1.0, "h2o_p": -1.0}, "id": "GPDDA2pp", "gene_reaction_rule": "STM2282"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerophosphodiester phosphodiesterase (Glycerophosphoserine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GPDDA3"]}, "metabolites": {"glyc3p_c": 1.0, "ser__L_c": 1.0, "h_c": 1.0, "h2o_c": -1.0, "g3ps_c": -1.0}, "id": "GPDDA3", "gene_reaction_rule": "STM3553"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerophosphodiester phosphodiesterase (Glycerophosphoserine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GPDDA3pp"]}, "metabolites": {"g3ps_p": -1.0, "glyc3p_p": 1.0, "ser__L_p": 1.0, "h_p": 1.0, "h2o_p": -1.0}, "id": "GPDDA3pp", "gene_reaction_rule": "STM2282"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerophosphodiester phosphodiesterase (Glycerophosphoglycerol)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GPDDA4"]}, "metabolites": {"g3pg_c": -1.0, "h2o_c": -1.0, "glyc_c": 1.0, "glyc3p_c": 1.0, "h_c": 1.0}, "id": "GPDDA4", "gene_reaction_rule": "STM3553"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerophosphodiester phosphodiesterase (Glycerophosphoglycerol)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GPDDA4pp"]}, "metabolites": {"glyc3p_p": 1.0, "g3pg_p": -1.0, "glyc_p": 1.0, "h_p": 1.0, "h2o_p": -1.0}, "id": "GPDDA4pp", "gene_reaction_rule": "STM2282"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerophosphodiester phosphodiesterase (Glycerophosphoinositol)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GPDDA5"]}, "metabolites": {"h2o_c": -1.0, "g3pi_c": -1.0, "inost_c": 1.0, "glyc3p_c": 1.0, "h_c": 1.0}, "id": "GPDDA5", "gene_reaction_rule": "STM3553"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerophosphodiester phosphodiesterase (Glycerophosphoinositol)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GPDDA5pp"]}, "metabolites": {"g3pi_p": -1.0, "glyc3p_p": 1.0, "inost_p": 1.0, "h_p": 1.0, "h2o_p": -1.0}, "id": "GPDDA5pp", "gene_reaction_rule": "STM2282"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Geranyltranstransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GRTT"]}, "metabolites": {"ppi_c": 1.0, "ipdp_c": -1.0, "frdp_c": 1.0, "grdp_c": -1.0}, "id": "GRTT", "gene_reaction_rule": "STM0423"}, {"subsystem": "Unassigned", "name": "Glutaredoxin reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GRXR"]}, "metabolites": {"grxox_c": -1.0, "gthrd_c": -2.0, "grxrd_c": 1.0, "gthox_c": 1.0}, "id": "GRXR", "gene_reaction_rule": "STM3702 or STM0872 or STM1433 or STM1165"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Guanosine kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GSNK"]}, "metabolites": {"gmp_c": 1.0, "gsn_c": -1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "GSNK", "gene_reaction_rule": "STM0491"}, {"subsystem": "Transport Inner Membrane", "name": "Guanosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GSNt2pp"]}, "metabolites": {"gsn_p": -1.0, "h_c": 1.0, "h_p": -1.0, "gsn_c": 1.0}, "id": "GSNt2pp", "gene_reaction_rule": "STM3113"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Guanosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GSNtex"]}, "metabolites": {"gsn_e": -1.0, "gsn_p": 1.0}, "id": "GSNtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Glutathionylspermidine amidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GSPMDA"]}, "metabolites": {"gtspmd_c": -1.0, "h2o_c": -1.0, "gthrd_c": 1.0, "spmd_c": 1.0}, "id": "GSPMDA", "gene_reaction_rule": "STM3139"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Glutathionylspermidine synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GSPMDS"]}, "metabolites": {"spmd_c": -1.0, "atp_c": -1.0, "gtspmd_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "gthrd_c": -1.0}, "id": "GSPMDS", "gene_reaction_rule": "STM3139"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Glutathione (ox) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GTHOXtex"]}, "metabolites": {"gthox_e": -1.0, "gthox_p": 1.0}, "id": "GTHOXtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Glutathione oxidoreductase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GTHOr"]}, "metabolites": {"gthrd_c": 2.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "gthox_c": -1.0}, "id": "GTHOr", "gene_reaction_rule": "STM3597"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Glutathione hydralase (periplasmic)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GTHRDHpp"]}, "metabolites": {"glu__L_p": 1.0, "gthrd_p": -1.0, "cgly_p": 1.0, "h2o_p": -1.0}, "id": "GTHRDHpp", "gene_reaction_rule": "STM3551"}, {"subsystem": "Transport Inner Membrane", "name": "Glutathione export via ABC system (cytoplasm to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GTHRDabc2pp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "gthrd_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "gthrd_c": -1.0}, "id": "GTHRDabc2pp", "gene_reaction_rule": "STM0956 and STM0957"}, {"subsystem": "Transport Inner Membrane", "name": "Reduced glutathione via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GTHRDabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "gthrd_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "gthrd_c": 1.0}, "id": "GTHRDabcpp", "gene_reaction_rule": "STM0848 and STM0849 and STM0850 and STM0851"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Glutathione transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GTHRDtex"]}, "metabolites": {"gthrd_e": -1.0, "gthrd_p": 1.0}, "id": "GTHRDtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Glutathione synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GTHS"]}, "metabolites": {"pi_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "glucys_c": -1.0, "gthrd_c": 1.0, "gly_c": -1.0}, "id": "GTHS", "gene_reaction_rule": "STM3095"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "GTP cyclohydrolase I", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GTPCI"]}, "metabolites": {"h2o_c": -1.0, "gtp_c": -1.0, "h_c": 1.0, "for_c": 1.0, "ahdt_c": 1.0}, "id": "GTPCI", "gene_reaction_rule": "STM2193"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "GTP cyclohydrolase II (25drapp)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GTPCII2"]}, "metabolites": {"h2o_c": -3.0, "ppi_c": 1.0, "gtp_c": -1.0, "25drapp_c": 1.0, "for_c": 1.0, "h_c": 2.0}, "id": "GTPCII2", "gene_reaction_rule": "STM1711"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Guanosine-5'-triphosphate,3'-diphosphate diphosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GTPDPDP"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "gdptp_c": -1.0, "ppgpp_c": 1.0, "h_c": 1.0}, "id": "GTPDPDP", "gene_reaction_rule": "STM3913"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "GTP diphosphokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GTPDPK"]}, "metabolites": {"gdptp_c": 1.0, "gtp_c": -1.0, "amp_c": 1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "GTPDPK", "gene_reaction_rule": "STM2956"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "GTP amine hydrolysis (spontaneous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GTPHs"]}, "metabolites": {"h2o_c": -1.0, "xtp_c": 1.0, "gtp_c": -1.0, "nh4_c": 1.0, "h_c": -1.0}, "id": "GTPHs", "gene_reaction_rule": "s0001"}, {"subsystem": "Transport Outer Membrane Porin", "name": "GTP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GTPtex"]}, "metabolites": {"gtp_e": -1.0, "gtp_p": 1.0}, "id": "GTPtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Guanine phosphoribosyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GUAPRT"]}, "metabolites": {"gua_c": -1.0, "gmp_c": 1.0, "ppi_c": 1.0, "prpp_c": -1.0}, "id": "GUAPRT", "gene_reaction_rule": "STM0317 or STM0170"}, {"subsystem": "Transport Inner Membrane", "name": "Guanine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GUAt2pp"]}, "metabolites": {"gua_p": -1.0, "gua_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GUAt2pp", "gene_reaction_rule": "STM3747"}, {"subsystem": "Transport Outer Membrane", "name": "Guanine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GUAtex"]}, "metabolites": {"gua_p": 1.0, "gua_e": -1.0}, "id": "GUAtex", "gene_reaction_rule": "STM0413"}, {"subsystem": "Transport Inner Membrane", "name": "Guanine transport via diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GUAtpp"]}, "metabolites": {"gua_p": -1.0, "gua_c": 1.0}, "id": "GUAtpp", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glucuronate 1-phosphate phosphatase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GUR1PPpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "glcur1p_p": -1.0, "glcur_p": 1.0}, "id": "GUR1PPpp", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "Hydrogen peroxide transport via diffusion (external)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["H2O2tex"]}, "metabolites": {"h2o2_p": 1.0, "h2o2_e": -1.0}, "id": "H2O2tex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane", "name": "H2O transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["H2Otex"]}, "metabolites": {"h2o_p": 1.0, "h2o_e": -1.0}, "id": "H2Otex", "gene_reaction_rule": "STM1473 or STM0999 or STM2267 or STM0320 or s0001 or STM4016"}, {"subsystem": "Transport Inner Membrane", "name": "H2O transport via diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["H2Otpp"]}, "metabolites": {"h2o_p": -1.0, "h2o_c": 1.0}, "id": "H2Otpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Hydrogen sulfide oxidation", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["H2SO"]}, "metabolites": {"o2_c": -2.0, "h_c": 2.0, "h2s_c": -1.0, "so4_c": 1.0}, "id": "H2SO", "gene_reaction_rule": ""}, {"subsystem": "Transport Inner Membrane", "name": "H2s transport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["H2St1pp"]}, "metabolites": {"h2s_p": 1.0, "h2s_c": -1.0}, "id": "H2St1pp", "gene_reaction_rule": "s0001"}, {"subsystem": "Transport Outer Membrane Porin", "name": "H2s transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["H2Stex"]}, "metabolites": {"h2s_e": -1.0, "h2s_p": 1.0}, "id": "H2Stex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Hydrogen transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["H2tex"]}, "metabolites": {"h2_e": -1.0, "h2_p": 1.0}, "id": "H2tex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "Hydrogen transport diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["H2tpp"]}, "metabolites": {"h2_c": 1.0, "h2_p": -1.0}, "id": "H2tpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HACD1i"]}, "metabolites": {"aacoa_c": 1.0, "3hbcoa_c": -1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "HACD1i", "gene_reaction_rule": "STM3983 or STM2388"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxohexanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HACD2i"]}, "metabolites": {"3hhcoa_c": -1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0, "3ohcoa_c": 1.0}, "id": "HACD2i", "gene_reaction_rule": "STM3983 or STM2388"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxooctanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HACD3i"]}, "metabolites": {"h_c": 1.0, "nadh_c": 1.0, "3oocoa_c": 1.0, "nad_c": -1.0, "3hocoa_c": -1.0}, "id": "HACD3i", "gene_reaction_rule": "STM2388 or STM3983"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxodecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HACD4i"]}, "metabolites": {"nadh_c": 1.0, "3hdcoa_c": -1.0, "nad_c": -1.0, "3odcoa_c": 1.0, "h_c": 1.0}, "id": "HACD4i", "gene_reaction_rule": "STM3983 or STM2388"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxododecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HACD5i"]}, "metabolites": {"3oddcoa_c": 1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0, "3hddcoa_c": -1.0}, "id": "HACD5i", "gene_reaction_rule": "STM3983 or STM2388"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxotetradecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HACD6i"]}, "metabolites": {"3otdcoa_c": 1.0, "3htdcoa_c": -1.0, "nadh_c": 1.0, "nad_c": -1.0, "h_c": 1.0}, "id": "HACD6i", "gene_reaction_rule": "STM3983 or STM2388"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxohexadecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HACD7i"]}, "metabolites": {"nad_c": -1.0, "nadh_c": 1.0, "h_c": 1.0, "3ohdcoa_c": 1.0, "3hhdcoa_c": -1.0}, "id": "HACD7i", "gene_reaction_rule": "STM3983 or STM2388"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxooctadecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HACD8i"]}, "metabolites": {"3hodcoa_c": -1.0, "3oodcoa_c": 1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "HACD8i", "gene_reaction_rule": "STM3983 or STM2388"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Hydroxybenzoate octaprenyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HBZOPT"]}, "metabolites": {"4hbz_c": -1.0, "3ophb_c": 1.0, "ppi_c": 1.0, "octdp_c": -1.0}, "id": "HBZOPT", "gene_reaction_rule": "STM4234"}, {"subsystem": "Transport Outer Membrane Porin", "name": "3-hydroxycinnamic acid transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HCINNMtex"]}, "metabolites": {"3hcinnm_e": -1.0, "3hcinnm_p": 1.0}, "id": "HCINNMtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Unassigned", "name": "HCO3 equilibration reaction", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HCO3E"]}, "metabolites": {"hco3_c": 1.0, "h2o_c": -1.0, "co2_c": -1.0, "h_c": 1.0}, "id": "HCO3E", "gene_reaction_rule": "STM0171"}, {"subsystem": "Transport Outer Membrane", "name": "Hexadecanoate transport via facilitated irreversible diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HDCAtexi"]}, "metabolites": {"hdca_e": -1.0, "hdca_p": 1.0}, "id": "HDCAtexi", "gene_reaction_rule": "STM2391"}, {"subsystem": "Transport Outer Membrane", "name": "Hexadecenoate transport via facilitated irreversible diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HDCEAtexi"]}, "metabolites": {"hdcea_p": 1.0, "hdcea_e": -1.0}, "id": "HDCEAtexi", "gene_reaction_rule": "STM2391"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-cis-2-trans-enoyl-CoA isomerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HDCOAI"]}, "metabolites": {"hdcoa_c": -1.0, "hdd2coa_c": 1.0}, "id": "CTECOAI7", "gene_reaction_rule": "STM3983"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Heme O synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEMEOS"]}, "metabolites": {"h2o_c": -1.0, "hemeO_c": 1.0, "frdp_c": -1.0, "ppi_c": 1.0, "pheme_c": -1.0}, "id": "HEMEOS", "gene_reaction_rule": "STM0439"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "LPS heptose kinase I (LPS core synthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEPK1"]}, "metabolites": {"hhlipa_c": -1.0, "phhlipa_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "HEPK1", "gene_reaction_rule": "STM3721"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "LPS heptose kinase II (LPS core synthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEPK2"]}, "metabolites": {"hphhlipa_c": -1.0, "phphhlipa_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "HEPK2", "gene_reaction_rule": "STM3716"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Heptosyltransferase I (LPS core synthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEPT1"]}, "metabolites": {"adp_c": 1.0, "lipa_c": -1.0, "hlipa_c": 1.0, "adphep_LD_c": -1.0, "h_c": 1.0}, "id": "HEPT1", "gene_reaction_rule": "STM3712"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Heptosyltransferase II (LPS core synthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEPT2"]}, "metabolites": {"adp_c": 1.0, "hhlipa_c": 1.0, "hlipa_c": -1.0, "adphep_LD_c": -1.0, "h_c": 1.0}, "id": "HEPT2", "gene_reaction_rule": "STM3711"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Heptosyltransferase III (LPS core synthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEPT3"]}, "metabolites": {"hphhlipa_c": 1.0, "phhlipa_c": -1.0, "h_c": 1.0, "adphep_LD_c": -1.0, "adp_c": 1.0}, "id": "HEPT3", "gene_reaction_rule": "STM3723"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Heptosyltransferase IV (LPS core synthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEPT4"]}, "metabolites": {"colipa_c": 1.0, "gggagicolipa_c": -1.0, "adp_c": 1.0, "adphep_LD_c": -1.0, "h_c": 1.0}, "id": "HEPT4", "gene_reaction_rule": "STM3714"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Hydroxyethylthiazole kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HETZK"]}, "metabolites": {"4mpetz_c": 1.0, "4mhetz_c": -1.0, "adp_c": 1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "HETZK", "gene_reaction_rule": "STM2147"}, {"subsystem": "GlycolysisGluconeogenesis", "name": "Hexokinase (D-glucose:ATP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEX1"]}, "metabolites": {"glc__D_c": -1.0, "g6p_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "HEX1", "gene_reaction_rule": "STM2403"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Hexokinase (D-mannose:ATP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEX4"]}, "metabolites": {"man6p_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "man_c": -1.0}, "id": "HEX4", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Hexokinase (D-fructose:ATP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEX7"]}, "metabolites": {"adp_c": 1.0, "fru_c": -1.0, "h_c": 1.0, "atp_c": -1.0, "f6p_c": 1.0}, "id": "HEX7", "gene_reaction_rule": "STM0393"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Mercury (Hg+2) ABC transporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HG2abcpp"]}, "metabolites": {"h2o_c": -1.0, "hg2_p": 1.0, "atp_c": -1.0, "hg2_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "HG2abcpp", "gene_reaction_rule": "STM3576"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Mercury (Hg+2) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HG2tex"]}, "metabolites": {"hg2_p": 1.0, "hg2_e": -1.0}, "id": "HG2tex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Histidine Metabolism", "name": "Histidinol dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HISTD"]}, "metabolites": {"histd_c": -1.0, "h2o_c": -1.0, "his__L_c": 1.0, "h_c": 3.0, "nad_c": -2.0, "nadh_c": 2.0}, "id": "HISTD", "gene_reaction_rule": "STM2072"}, {"subsystem": "Histidine Metabolism", "name": "Histidinol-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HISTP"]}, "metabolites": {"hisp_c": -1.0, "histd_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0}, "id": "HISTP", "gene_reaction_rule": "STM2074"}, {"subsystem": "tRNA Charging", "name": "Histidyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HISTRS"]}, "metabolites": {"histrna_c": 1.0, "atp_c": -1.0, "his__L_c": -1.0, "ppi_c": 1.0, "trnahis_c": -1.0, "amp_c": 1.0}, "id": "HISTRS", "gene_reaction_rule": "STM2522"}, {"subsystem": "Transport Inner Membrane", "name": "L-histidine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HISabcpp"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "atp_c": -1.0, "his__L_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "his__L_p": -1.0}, "id": "HISabcpp", "gene_reaction_rule": "STM2354 and STM2352 and STM2351 and STM2353"}, {"subsystem": "Transport Inner Membrane", "name": "L-histidine reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HISt2rpp"]}, "metabolites": {"his__L_c": 1.0, "his__L_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "HISt2rpp", "gene_reaction_rule": "STM0150"}, {"subsystem": "Transport Outer Membrane Porin", "name": "L-histidine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HIStex"]}, "metabolites": {"his__L_p": 1.0, "his__L_e": -1.0}, "id": "HIStex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Hydroxymethylbilane synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HMBS"]}, "metabolites": {"ppbng_c": -4.0, "hmbil_c": 1.0, "nh4_c": 4.0, "h2o_c": -1.0}, "id": "HMBS", "gene_reaction_rule": "STM3938"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Hydroxymethylpyrimidine kinase (ATP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HMPK1"]}, "metabolites": {"h_c": 1.0, "4ampm_c": 1.0, "atp_c": -1.0, "adp_c": 1.0, "4ahmmp_c": -1.0}, "id": "HMPK1", "gene_reaction_rule": "STM2146 or STM2435"}, {"subsystem": "Transport Inner Membrane", "name": "L-homoserineserine efflux via proton symport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HOMt2pp"]}, "metabolites": {"hom__L_c": -1.0, "hom__L_p": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "HOMt2pp", "gene_reaction_rule": "STM0832 or STM3960"}, {"subsystem": "Transport Outer Membrane Porin", "name": "L-homoserine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HOMtex"]}, "metabolites": {"hom__L_p": 1.0, "hom__L_e": -1.0}, "id": "HOMtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "6-hydroxymethyl-dihydropterin pyrophosphokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HPPK2"]}, "metabolites": {"6hmhptpp_c": 1.0, "6hmhpt_c": -1.0, "h_c": 1.0, "atp_c": -1.0, "amp_c": 1.0}, "id": "HPPK2", "gene_reaction_rule": "STM0183"}, {"subsystem": "Transport Outer Membrane Porin", "name": "3-(3-hydroxyphenyl)propionate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HPPPNtex"]}, "metabolites": {"3hpppn_e": -1.0, "3hpppn_p": 1.0}, "id": "HPPPNtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Hydroxypyruvate isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HPYRI"]}, "metabolites": {"hpyr_c": -1.0, "2h3oppan_c": 1.0}, "id": "HPYRI", "gene_reaction_rule": "STM0518"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Hydroxypyruvate reductase (NADH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HPYRRx"]}, "metabolites": {"hpyr_c": -1.0, "nadh_c": -1.0, "glyc__R_c": 1.0, "h_c": -1.0, "nad_c": 1.0}, "id": "HPYRRx", "gene_reaction_rule": "STM1135 or STM3646"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Hydroxypyruvate reductase (NADPH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HPYRRy"]}, "metabolites": {"glyc__R_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "hpyr_c": -1.0}, "id": "HPYRRy", "gene_reaction_rule": "STM3646 or STM1135"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Homoserine dehydrogenase (NADPH)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HSDy"]}, "metabolites": {"hom__L_c": -1.0, "aspsa_c": 1.0, "nadp_c": -1.0, "nadph_c": 1.0, "h_c": 1.0}, "id": "HSDy", "gene_reaction_rule": "STM4101 or STM0002"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Homoserine kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HSK"]}, "metabolites": {"phom_c": 1.0, "hom__L_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "HSK", "gene_reaction_rule": "STM0003"}, {"subsystem": "Methionine Metabolism", "name": "Homoserine O-succinyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HSST"]}, "metabolites": {"hom__L_c": -1.0, "succoa_c": -1.0, "suchms_c": 1.0, "coa_c": 1.0}, "id": "HSST", "gene_reaction_rule": "STM4182"}, {"subsystem": "Histidine Metabolism", "name": "Histidinol-phosphate transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HSTPT"]}, "metabolites": {"akg_c": 1.0, "hisp_c": 1.0, "glu__L_c": -1.0, "imacp_c": -1.0}, "id": "HSTPT", "gene_reaction_rule": "STM2073"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Hexanoate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HXAtex"]}, "metabolites": {"hxa_p": 1.0, "hxa_e": -1.0}, "id": "HXAtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Hypoxanthine phosphoribosyltransferase (Hypoxanthine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HXPRT"]}, "metabolites": {"ppi_c": 1.0, "imp_c": 1.0, "prpp_c": -1.0, "hxan_c": -1.0}, "id": "HXPRT", "gene_reaction_rule": "STM0317 or STM0170"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Hypothetical enyme", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HYPOE"]}, "metabolites": {"pydam_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0, "pyam5p_c": -1.0}, "id": "HYPOE", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "Hypoxanthine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HYXNtex"]}, "metabolites": {"hxan_e": -1.0, "hxan_p": 1.0}, "id": "HYXNtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "Hypoxanthine transport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HYXNtpp"]}, "metabolites": {"hxan_c": 1.0, "hxan_p": -1.0}, "id": "HYXNtpp", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "Proton transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["Htex"]}, "metabolites": {"h_e": -1.0, "h_p": 1.0}, "id": "Htex", "gene_reaction_rule": "STM0999 or STM1473 or STM2267 or STM0320"}, {"subsystem": "Citric Acid Cycle", "name": "Isocitrate dehydrogenase (NADP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ICDHyr"]}, "metabolites": {"akg_c": 1.0, "co2_c": 1.0, "icit_c": -1.0, "nadph_c": 1.0, "nadp_c": -1.0}, "id": "ICDHyr", "gene_reaction_rule": "STM1238"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Isochorismate synthase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ICHORS", "ICHORSi"]}, "metabolites": {"chor_c": -1.0, "ichor_c": 1.0}, "id": "ICHORS_copy1", "gene_reaction_rule": "STM2310"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Isochorismate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ICHORS", "ICHORSi"]}, "metabolites": {"chor_c": -1.0, "ichor_c": 1.0}, "id": "ICHORS_copy2", "gene_reaction_rule": "STM0595 or STM2310"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Isochorismatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ICHORT"]}, "metabolites": {"pyr_c": 1.0, "h2o_c": -1.0, "ichor_c": -1.0, "23ddhb_c": 1.0}, "id": "ICHORT", "gene_reaction_rule": "STM0597"}, {"subsystem": "Anaplerotic Reactions", "name": "Isocitrate lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ICL"]}, "metabolites": {"succ_c": 1.0, "icit_c": -1.0, "glx_c": 1.0}, "id": "ICL", "gene_reaction_rule": "STM4184"}, {"subsystem": "Alternate Carbon Metabolism", "name": "L-idonate 5-dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IDOND"]}, "metabolites": {"idon__L_c": 1.0, "5dglcn_c": -1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0}, "id": "IDOND", "gene_reaction_rule": "STM4484"}, {"subsystem": "Alternate Carbon Metabolism", "name": "L-indonate 5-dehydrogenase (NADP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IDOND2"]}, "metabolites": {"idon__L_c": 1.0, "5dglcn_c": -1.0, "nadph_c": -1.0, "h_c": -1.0, "nadp_c": 1.0}, "id": "IDOND2", "gene_reaction_rule": "STM4484"}, {"subsystem": "Transport Inner Membrane", "name": "L-idonate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IDONt2rpp"]}, "metabolites": {"idon__L_c": 1.0, "idon__L_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "IDONt2rpp", "gene_reaction_rule": "STM4482"}, {"subsystem": "Transport Outer Membrane Porin", "name": "L-idonate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IDONtex"]}, "metabolites": {"idon__L_p": 1.0, "idon__L_e": -1.0}, "id": "IDONtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Histidine Metabolism", "name": "Imidazole-glycerol-3-phosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IG3PS"]}, "metabolites": {"aicar_c": 1.0, "glu__L_c": 1.0, "eig3p_c": 1.0, "h_c": 1.0, "prlp_c": -1.0, "gln__L_c": -1.0}, "id": "IG3PS", "gene_reaction_rule": "STM2075 and STM2077"}, {"subsystem": "Histidine Metabolism", "name": "Imidazoleglycerol-phosphate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IGPDH"]}, "metabolites": {"h2o_c": 1.0, "imacp_c": 1.0, "eig3p_c": -1.0}, "id": "IGPDH", "gene_reaction_rule": "STM2074"}, {"subsystem": "Tyrosine Tryptophan and Phenylalanine Metabolism", "name": "Indole-3-glycerol-phosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IGPS"]}, "metabolites": {"h2o_c": 1.0, "co2_c": 1.0, "h_c": -1.0, "2cpr5p_c": -1.0, "3ig3p_c": 1.0}, "id": "IGPS", "gene_reaction_rule": "STM1725"}, {"subsystem": "Valine Leucine and Isoleucine Metabolism", "name": "Isoleucine transaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ILETA"]}, "metabolites": {"akg_c": -1.0, "3mop_c": 1.0, "glu__L_c": 1.0, "ile__L_c": -1.0}, "id": "ILETA", "gene_reaction_rule": "STM3903"}, {"subsystem": "tRNA Charging", "name": "Isoleucyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ILETRS"]}, "metabolites": {"iletrna_c": 1.0, "trnaile_c": -1.0, "atp_c": -1.0, "ile__L_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0}, "id": "ILETRS", "gene_reaction_rule": "STM0046"}, {"subsystem": "Transport Inner Membrane", "name": "L-isoleucine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ILEabcpp"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "atp_c": -1.0, "ile__L_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "ile__L_p": -1.0}, "id": "ILEabcpp", "gene_reaction_rule": "STM3560 and STM3561 and STM3563 and STM3567 and STM3562"}, {"subsystem": "Transport Inner Membrane", "name": "L-isoleucine reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ILEt2rpp"]}, "metabolites": {"ile__L_c": 1.0, "ile__L_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "ILEt2rpp", "gene_reaction_rule": "STM0399"}, {"subsystem": "Transport Outer Membrane Porin", "name": "L-isoleucine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ILEtex"]}, "metabolites": {"ile__L_p": 1.0, "ile__L_e": -1.0}, "id": "ILEtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "IMP cyclohydrolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IMPC"]}, "metabolites": {"h2o_c": -1.0, "fprica_c": 1.0, "imp_c": -1.0}, "id": "IMPC", "gene_reaction_rule": "STM4176"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "IMP dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IMPD"]}, "metabolites": {"xmp_c": 1.0, "h2o_c": -1.0, "h_c": 1.0, "nad_c": -1.0, "nadh_c": 1.0, "imp_c": -1.0}, "id": "IMPD", "gene_reaction_rule": "STM2511"}, {"subsystem": "Transport Outer Membrane Porin", "name": "IMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IMPtex"]}, "metabolites": {"imp_e": -1.0, "imp_p": 1.0}, "id": "IMPtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "Indole transport via proton symport, irreversible (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["INDOLEt2pp"]}, "metabolites": {"h_p": 1.0, "indole_c": -1.0, "indole_p": 1.0, "h_c": -1.0}, "id": "INDOLEt2pp", "gene_reaction_rule": "STM3390 and STM3391"}, {"subsystem": "Transport Inner Membrane", "name": "Indole transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["INDOLEt2rpp"]}, "metabolites": {"indole_c": 1.0, "h_p": -1.0, "indole_p": -1.0, "h_c": 1.0}, "id": "INDOLEt2rpp", "gene_reaction_rule": "STM3279"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Indole transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["INDOLEtex"]}, "metabolites": {"indole_e": -1.0, "indole_p": 1.0}, "id": "INDOLEtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Inosine hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["INSH"]}, "metabolites": {"rib__D_c": 1.0, "h2o_c": -1.0, "hxan_c": 1.0, "ins_c": -1.0}, "id": "INSH", "gene_reaction_rule": "STM0051"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Insosine kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["INSK"]}, "metabolites": {"h_c": 1.0, "imp_c": 1.0, "atp_c": -1.0, "adp_c": 1.0, "ins_c": -1.0}, "id": "INSK", "gene_reaction_rule": "STM0491"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Inositol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["INSTtex"]}, "metabolites": {"inost_e": -1.0, "inost_p": 1.0}, "id": "INSTtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "Inosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["INSt2pp", "INSt2rpp"]}, "metabolites": {"ins_p": -1.0, "h_c": 1.0, "h_p": -1.0, "ins_c": 1.0}, "id": "INSt2pp_copy1", "gene_reaction_rule": "STM3113"}, {"subsystem": "Transport Inner Membrane", "name": "Inosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["INSt2pp", "INSt2rpp"]}, "metabolites": {"ins_p": -1.0, "h_c": 1.0, "h_p": -1.0, "ins_c": 1.0}, "id": "INSt2pp_copy2", "gene_reaction_rule": "STM2421"}, {"subsystem": "Transport Outer Membrane", "name": "Inosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["INStex"]}, "metabolites": {"ins_e": -1.0, "ins_p": 1.0}, "id": "INStex", "gene_reaction_rule": "STM0413"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Isopentenyl-diphosphate D-isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IPDDI"]}, "metabolites": {"dmpp_c": 1.0, "ipdp_c": -1.0}, "id": "IPDDI", "gene_reaction_rule": "STM3039"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (ipdp)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IPDPS"]}, "metabolites": {"h2o_c": 1.0, "ipdp_c": 1.0, "h2mb4p_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "nadh_c": -1.0}, "id": "IPDPS", "gene_reaction_rule": "STM0049"}, {"subsystem": "Valine Leucine and Isoleucine Metabolism", "name": "3-isopropylmalate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IPMD"]}, "metabolites": {"3c4mop_c": 1.0, "3c2hmp_c": -1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "IPMD", "gene_reaction_rule": "STM0112"}, {"subsystem": "Valine Leucine and Isoleucine Metabolism", "name": "3-isopropylmalate dehydratase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IPPMIa"]}, "metabolites": {"2ippm_c": 1.0, "h2o_c": 1.0, "3c2hmp_c": -1.0}, "id": "IPPMIa", "gene_reaction_rule": "(STM0110 and STM0111) or (STM0329 and STM0330)"}, {"subsystem": "Valine Leucine and Isoleucine Metabolism", "name": "2-isopropylmalate hydratase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IPPMIb"]}, "metabolites": {"2ippm_c": -1.0, "h2o_c": -1.0, "3c3hmp_c": 1.0}, "id": "IPPMIb", "gene_reaction_rule": "(STM0110 and STM0111) or (STM0329 and STM0330)"}, {"subsystem": "Valine Leucine and Isoleucine Metabolism", "name": "2-isopropylmalate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IPPS"]}, "metabolites": {"h2o_c": -1.0, "accoa_c": -1.0, "3mob_c": -1.0, "coa_c": 1.0, "h_c": 1.0, "3c3hmp_c": 1.0}, "id": "IPPS", "gene_reaction_rule": "STM0113"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Isethionate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ISETACtex"]}, "metabolites": {"isetac_p": 1.0, "isetac_e": -1.0}, "id": "ISETACtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "KDO(2)-lipid IV A transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["K2L4Aabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "kdo2lipid4_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "kdo2lipid4_c": -1.0, "pi_c": 1.0}, "id": "K2L4Aabcpp", "gene_reaction_rule": "STM0984"}, {"subsystem": "Transport Outer Membrane", "name": "KDO(2)-lipid IV A transport via vector (periplasm to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["K2L4Atex"]}, "metabolites": {"kdo2lipid4_p": -1.0, "kdo2lipid4_e": 1.0}, "id": "K2L4Atex", "gene_reaction_rule": ""}, {"subsystem": "Valine Leucine and Isoleucine Metabolism", "name": "Ketol-acid reductoisomerase (2,3-dihydroxy-3-methylbutanoate)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["KARA1"]}, "metabolites": {"nadp_c": -1.0, "nadph_c": 1.0, "h_c": 1.0, "23dhmb_c": -1.0, "alac__S_c": 1.0}, "id": "KARA1", "gene_reaction_rule": "STM3909"}, {"subsystem": "Valine Leucine and Isoleucine Metabolism", "name": "Ketol-acid reductoisomerase (2-Acetolactate)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["KARA2"]}, "metabolites": {"23dhmp_c": 1.0, "2ahbut_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0}, "id": "KARA2", "gene_reaction_rule": "STM3909"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Beta-ketoacyl-ACP synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KAS14"]}, "metabolites": {"acACP_c": -1.0, "ACP_c": 1.0, "malACP_c": -1.0, "h_c": -1.0, "actACP_c": 1.0, "co2_c": 1.0}, "id": "KAS14", "gene_reaction_rule": "STM2378 or STM1197"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Beta-ketoacyl-ACP synthase (2)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KAS15"]}, "metabolites": {"malACP_c": -1.0, "coa_c": 1.0, "h_c": -1.0, "accoa_c": -1.0, "actACP_c": 1.0, "co2_c": 1.0}, "id": "KAS15", "gene_reaction_rule": "STM1193"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-ketoacyl-CoA thiolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KAT1"]}, "metabolites": {"aacoa_c": -1.0, "coa_c": -1.0, "accoa_c": 2.0}, "id": "KAT1", "gene_reaction_rule": "STM2389 or STM3982"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-ketoacyl-CoA thiolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KAT2"]}, "metabolites": {"btcoa_c": 1.0, "coa_c": -1.0, "accoa_c": 1.0, "3ohcoa_c": -1.0}, "id": "KAT2", "gene_reaction_rule": "STM3982 or STM2389"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-ketoacyl-CoA thiolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KAT3"]}, "metabolites": {"coa_c": -1.0, "3oocoa_c": -1.0, "hxcoa_c": 1.0, "accoa_c": 1.0}, "id": "KAT3", "gene_reaction_rule": "STM2389 or STM3982"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-ketoacyl-CoA thiolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KAT4"]}, "metabolites": {"occoa_c": 1.0, "3odcoa_c": -1.0, "coa_c": -1.0, "accoa_c": 1.0}, "id": "KAT4", "gene_reaction_rule": "STM2389 or STM3982"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-ketoacyl-CoA thiolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KAT5"]}, "metabolites": {"3oddcoa_c": -1.0, "coa_c": -1.0, "dcacoa_c": 1.0, "accoa_c": 1.0}, "id": "KAT5", "gene_reaction_rule": "STM2389 or STM3982"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-ketoacyl-CoA thiolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KAT6"]}, "metabolites": {"ddcacoa_c": 1.0, "3otdcoa_c": -1.0, "coa_c": -1.0, "accoa_c": 1.0}, "id": "KAT6", "gene_reaction_rule": "STM3982 or STM2389"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-ketoacyl-CoA thiolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KAT7"]}, "metabolites": {"coa_c": -1.0, "tdcoa_c": 1.0, "3ohdcoa_c": -1.0, "accoa_c": 1.0}, "id": "KAT7", "gene_reaction_rule": "STM3982 or STM2389"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA acyltransferase (hexadecanoyl-CoA), (r)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KAT8"]}, "metabolites": {"pmtcoa_c": 1.0, "3oodcoa_c": -1.0, "coa_c": -1.0, "accoa_c": 1.0}, "id": "ACACT8r", "gene_reaction_rule": "STM3982 or STM2389"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "3-deoxy-manno-octulosonate cytidylyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KDOCT2"]}, "metabolites": {"ctp_c": -1.0, "ckdo_c": 1.0, "ppi_c": 1.0, "kdo_c": -1.0}, "id": "KDOCT2", "gene_reaction_rule": "STM0988"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "3-deoxy-manno-octulosonate-8-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KDOPP"]}, "metabolites": {"kdo8p_c": -1.0, "h2o_c": -1.0, "kdo_c": 1.0, "pi_c": 1.0}, "id": "KDOPP", "gene_reaction_rule": "STM3316"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "3-deoxy -D-manno-octulosonic -acid 8-phosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KDOPS"]}, "metabolites": {"ara5p_c": -1.0, "kdo8p_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0, "pep_c": -1.0}, "id": "KDOPS", "gene_reaction_rule": "STM1772"}, {"subsystem": "Alternate Carbon Metabolism", "name": "3-keto-L-gulonate 6-phosphate decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KG6PDC"]}, "metabolites": {"xu5p__L_c": 1.0, "3dhgulnp_c": -1.0, "co2_c": 1.0, "h_c": -1.0}, "id": "KG6PDC", "gene_reaction_rule": "STM4386 or STM3675"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Potassium ABC transporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["Kabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "k_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "k_c": 1.0, "pi_c": 1.0}, "id": "Kabcpp", "gene_reaction_rule": "STM0706 and STM0705 and STM0704"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Potassium transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["Kt2pp"]}, "metabolites": {"k_p": -1.0, "k_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "Kt2pp", "gene_reaction_rule": "STM3880 or (STM1695 and STM3409 and STM3986)"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Potassium transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["Kt3pp"]}, "metabolites": {"k_p": 1.0, "k_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "Kt3pp", "gene_reaction_rule": "STM3457 or STM0086 or STM1771 or STM0866"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Potassium transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["Ktex"]}, "metabolites": {"k_p": 1.0, "k_e": -1.0}, "id": "Ktex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "4-amino-4-deoxy-L-arabinotransferase (LPS lipid A modification, periplasmic face of membrane))", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LA4NTpp"]}, "metabolites": {"udcpp_p": 1.0, "acolipa_p": 1.0, "colipa_p": -1.0, "uLa4n_p": -1.0}, "id": "LA4NTpp", "gene_reaction_rule": "STM2301"}, {"subsystem": "Murein Recycling", "name": "L-alanyl-gamma-D-glutamyl-meso-diaminopimelate hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LADGMDH"]}, "metabolites": {"h2o_c": -1.0, "26dap__M_c": 1.0, "LalaDglu_c": 1.0, "LalaDgluMdap_c": -1.0}, "id": "LADGMDH", "gene_reaction_rule": "STM1680"}, {"subsystem": "Methylglyoxal Metabolism", "name": "D-Lactaldehyde:NAD+ 1-oxidoreductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LALDO2x"]}, "metabolites": {"nad_c": 1.0, "nadh_c": -1.0, "h_c": -1.0, "lald__D_c": 1.0, "mthgxl_c": -1.0}, "id": "LALDO2x", "gene_reaction_rule": "STM4108"}, {"subsystem": "Murein Recycling", "name": "L-alanyl-gamma-L-glutamate peptidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LALGP"]}, "metabolites": {"LalaLglu_c": -1.0, "ala__L_c": 1.0, "glu__L_c": 1.0, "h2o_c": -1.0}, "id": "LALGP", "gene_reaction_rule": "STM0316"}, {"subsystem": "Methylglyoxal Metabolism", "name": "Lacaldehyde reductase (R-propane-1,2-diol forming)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LCARR"]}, "metabolites": {"h_c": -1.0, "nadh_c": -1.0, "lald__D_c": -1.0, "nad_c": 1.0, "12ppd__R_c": 1.0}, "id": "LCARR", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Lacaldehyde reductase (S-propane-1,2-diol forming)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LCARS"]}, "metabolites": {"nadh_c": -1.0, "12ppd__S_c": 1.0, "lald__L_c": -1.0, "nad_c": 1.0, "h_c": -1.0}, "id": "LCARS", "gene_reaction_rule": "STM2973"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Lactose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LCTStex"]}, "metabolites": {"lcts_p": 1.0, "lcts_e": -1.0}, "id": "LCTStex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Pyruvate Metabolism", "name": "D-lactate dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LDH_D"]}, "metabolites": {"pyr_c": 1.0, "nadh_c": 1.0, "lac__D_c": -1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "LDH_D", "gene_reaction_rule": "STM2167 or STM1647"}, {"subsystem": "Oxidative Phosphorylation", "name": "D-lactate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LDH_D2"]}, "metabolites": {"q8h2_c": 1.0, "pyr_c": 1.0, "lac__D_c": -1.0, "q8_c": -1.0}, "id": "LDH_D2", "gene_reaction_rule": "STM2167"}, {"subsystem": "Valine Leucine and Isoleucine Metabolism", "name": "Leucine transaminase (irreversible)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LEUTAi"]}, "metabolites": {"akg_c": 1.0, "leu__L_c": 1.0, "4mop_c": -1.0, "glu__L_c": -1.0}, "id": "LEUTAi", "gene_reaction_rule": "STM3903 or STM4248"}, {"subsystem": "tRNA Charging", "name": "Leucyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LEUTRS"]}, "metabolites": {"leutrna_c": 1.0, "leu__L_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "trnaleu_c": -1.0}, "id": "LEUTRS", "gene_reaction_rule": "STM0648"}, {"subsystem": "Transport Inner Membrane", "name": "L-leucine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LEUabcpp"]}, "metabolites": {"leu__L_c": 1.0, "atp_c": -1.0, "h2o_c": -1.0, "leu__L_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "LEUabcpp", "gene_reaction_rule": "(STM3560 and STM3561 and STM3563 and STM3567 and STM3562) or (STM3560 and STM3561 and STM3563 and STM3564 and STM3562)"}, {"subsystem": "Transport Inner Membrane", "name": "L-leucine reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LEUt2rpp"]}, "metabolites": {"leu__L_p": -1.0, "leu__L_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "LEUt2rpp", "gene_reaction_rule": "STM0399"}, {"subsystem": "Transport Outer Membrane Porin", "name": "L-leucine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LEUtex"]}, "metabolites": {"leu__L_p": 1.0, "leu__L_e": -1.0}, "id": "LEUtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Methylglyoxal Metabolism", "name": "Lactoylglutathione lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LGTHL"]}, "metabolites": {"gthrd_c": -1.0, "lgt__S_c": 1.0, "mthgxl_c": -1.0}, "id": "LGTHL", "gene_reaction_rule": "STM1435 or STM0235"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Lipid (cold) A transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPACabcpp"]}, "metabolites": {"h2o_c": -1.0, "lipa_cold_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "lipa_cold_p": 1.0, "pi_c": 1.0}, "id": "LIPACabcpp", "gene_reaction_rule": "STM0984"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Lipid A transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPAabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "lipa_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "lipa_c": -1.0}, "id": "LIPAabcpp", "gene_reaction_rule": "STM0984"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Lipid A transport via vector (periplasm to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPAtex"]}, "metabolites": {"lipa_e": 1.0, "lipa_p": -1.0}, "id": "LIPAtex", "gene_reaction_rule": ""}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Lipid A disaccaride synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPADSS"]}, "metabolites": {"udp_c": 1.0, "u23ga_c": -1.0, "lipidAds_c": 1.0, "h_c": 1.0, "lipidX_c": -1.0}, "id": "LPADSS", "gene_reaction_rule": "STM0229"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphotidate, n-C12:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1A120pp"]}, "metabolites": {"glyc3p_p": 1.0, "1ddecg3p_p": -1.0, "ddca_p": 1.0, "h_p": 1.0, "h2o_p": -1.0}, "id": "LPLIPAL1A120pp", "gene_reaction_rule": "STM0506"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphotidate, n-C14:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1A140pp"]}, "metabolites": {"glyc3p_p": 1.0, "1tdecg3p_p": -1.0, "h_p": 1.0, "ttdca_p": 1.0, "h2o_p": -1.0}, "id": "LPLIPAL1A140pp", "gene_reaction_rule": "STM0506"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphotidate, n-C14:1) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1A141pp"]}, "metabolites": {"glyc3p_p": 1.0, "ttdcea_p": 1.0, "1tdec7eg3p_p": -1.0, "h_p": 1.0, "h2o_p": -1.0}, "id": "LPLIPAL1A141pp", "gene_reaction_rule": "STM0506"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphotidate, n-C16:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1A160pp"]}, "metabolites": {"h2o_p": -1.0, "glyc3p_p": 1.0, "h_p": 1.0, "1hdecg3p_p": -1.0, "hdca_p": 1.0}, "id": "LPLIPAL1A160pp", "gene_reaction_rule": "STM0506"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphotidate, n-C16:1) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1A161pp"]}, "metabolites": {"glyc3p_p": 1.0, "1hdec9eg3p_p": -1.0, "hdcea_p": 1.0, "h_p": 1.0, "h2o_p": -1.0}, "id": "LPLIPAL1A161pp", "gene_reaction_rule": "STM0506"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphotidate, n-C18:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1A180pp"]}, "metabolites": {"glyc3p_p": 1.0, "ocdca_p": 1.0, "1odecg3p_p": -1.0, "h_p": 1.0, "h2o_p": -1.0}, "id": "LPLIPAL1A180pp", "gene_reaction_rule": "STM0506"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphotidate, n-C18:1) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1A181pp"]}, "metabolites": {"glyc3p_p": 1.0, "ocdcea_p": 1.0, "1odec11eg3p_p": -1.0, "h_p": 1.0, "h2o_p": -1.0}, "id": "LPLIPAL1A181pp", "gene_reaction_rule": "STM0506"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphoethanolamine, n-C12:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1E120pp"]}, "metabolites": {"h2o_p": -1.0, "ddca_p": 1.0, "g3pe_p": 1.0, "1agpe120_p": -1.0, "h_p": 1.0}, "id": "LPLIPAL1E120pp", "gene_reaction_rule": "STM0506"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphoethanolamine, n-C14:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1E140pp"]}, "metabolites": {"h_p": 1.0, "h2o_p": -1.0, "g3pe_p": 1.0, "ttdca_p": 1.0, "1agpe140_p": -1.0}, "id": "LPLIPAL1E140pp", "gene_reaction_rule": "STM0506"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphoethanolamine, n-C14:1) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1E141pp"]}, "metabolites": {"h2o_p": -1.0, "g3pe_p": 1.0, "ttdcea_p": 1.0, "h_p": 1.0, "1agpe141_p": -1.0}, "id": "LPLIPAL1E141pp", "gene_reaction_rule": "STM0506"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphoethanolamine, n-C16:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1E160pp"]}, "metabolites": {"1agpe160_p": -1.0, "h2o_p": -1.0, "g3pe_p": 1.0, "h_p": 1.0, "hdca_p": 1.0}, "id": "LPLIPAL1E160pp", "gene_reaction_rule": "STM0506"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphoethanolamine, n-C16:1) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1E161pp"]}, "metabolites": {"h2o_p": -1.0, "hdcea_p": 1.0, "g3pe_p": 1.0, "h_p": 1.0, "1agpe161_p": -1.0}, "id": "LPLIPAL1E161pp", "gene_reaction_rule": "STM0506"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphoethanolamine, n-C18:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1E180pp"]}, "metabolites": {"h2o_p": -1.0, "1agpe180_p": -1.0, "ocdca_p": 1.0, "g3pe_p": 1.0, "h_p": 1.0}, "id": "LPLIPAL1E180pp", "gene_reaction_rule": "STM0506"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphoethanolamine, n-C18:1) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1E181pp"]}, "metabolites": {"h2o_p": -1.0, "ocdcea_p": 1.0, "1agpe181_p": -1.0, "g3pe_p": 1.0, "h_p": 1.0}, "id": "LPLIPAL1E181pp", "gene_reaction_rule": "STM0506"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphoglycerol, n-C12:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1G120pp"]}, "metabolites": {"h2o_p": -1.0, "g3pg_p": 1.0, "ddca_p": 1.0, "h_p": 1.0, "1agpg120_p": -1.0}, "id": "LPLIPAL1G120pp", "gene_reaction_rule": "STM0506"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphoglycerol, n-C14:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1G140pp"]}, "metabolites": {"h2o_p": -1.0, "g3pg_p": 1.0, "1agpg140_p": -1.0, "ttdca_p": 1.0, "h_p": 1.0}, "id": "LPLIPAL1G140pp", "gene_reaction_rule": "STM0506"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphoglycerol, n-C14:1) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1G141pp"]}, "metabolites": {"h2o_p": -1.0, "g3pg_p": 1.0, "ttdcea_p": 1.0, "1agpg141_p": -1.0, "h_p": 1.0}, "id": "LPLIPAL1G141pp", "gene_reaction_rule": "STM0506"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphoglycerol, n-C16:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1G160pp"]}, "metabolites": {"h2o_p": -1.0, "g3pg_p": 1.0, "1agpg160_p": -1.0, "h_p": 1.0, "hdca_p": 1.0}, "id": "LPLIPAL1G160pp", "gene_reaction_rule": "STM0506"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphoglycerol, n-C16:1) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1G161pp"]}, "metabolites": {"hdcea_p": 1.0, "h2o_p": -1.0, "g3pg_p": 1.0, "1agpg161_p": -1.0, "h_p": 1.0}, "id": "LPLIPAL1G161pp", "gene_reaction_rule": "STM0506"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphoglycerol, n-C18:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1G180pp"]}, "metabolites": {"1agpg180_p": -1.0, "h2o_p": -1.0, "g3pg_p": 1.0, "ocdca_p": 1.0, "h_p": 1.0}, "id": "LPLIPAL1G180pp", "gene_reaction_rule": "STM0506"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphoglycerol, n-C18:1) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1G181pp"]}, "metabolites": {"h2o_p": -1.0, "g3pg_p": 1.0, "ocdcea_p": 1.0, "h_p": 1.0, "1agpg181_p": -1.0}, "id": "LPLIPAL1G181pp", "gene_reaction_rule": "STM0506"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphotidate, n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2A120"]}, "metabolites": {"ddca_c": 1.0, "h2o_c": -1.0, "2ddecg3p_c": -1.0, "glyc3p_c": 1.0, "h_c": 2.0}, "id": "LPLIPAL2A120", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphotidate, n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2A140"]}, "metabolites": {"h_c": 2.0, "h2o_c": -1.0, "2tdecg3p_c": -1.0, "glyc3p_c": 1.0, "ttdca_c": 1.0}, "id": "LPLIPAL2A140", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphotidate, n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2A141"]}, "metabolites": {"h2o_c": -1.0, "glyc3p_c": 1.0, "h_c": 2.0, "2tdec7eg3p_c": -1.0, "ttdcea_c": 1.0}, "id": "LPLIPAL2A141", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphotidate, n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2A160"]}, "metabolites": {"2hdecg3p_c": -1.0, "h2o_c": -1.0, "hdca_c": 1.0, "glyc3p_c": 1.0, "h_c": 2.0}, "id": "LPLIPAL2A160", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphotidate, n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2A161"]}, "metabolites": {"2hdec9eg3p_c": -1.0, "hdcea_c": 1.0, "glyc3p_c": 1.0, "h_c": 2.0, "h2o_c": -1.0}, "id": "LPLIPAL2A161", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphotidate, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2A180"]}, "metabolites": {"h_c": 2.0, "h2o_c": -1.0, "2odecg3p_c": -1.0, "glyc3p_c": 1.0, "ocdca_c": 1.0}, "id": "LPLIPAL2A180", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphotidate, n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2A181"]}, "metabolites": {"ocdcea_c": 1.0, "glyc3p_c": 1.0, "h_c": 2.0, "h2o_c": -1.0, "2odec11eg3p_c": -1.0}, "id": "LPLIPAL2A181", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoethanolamine, n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATE120"]}, "metabolites": {"2agpe120_c": -1.0, "apg120_c": 1.0, "pg120_c": -1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2ATE120", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoethanolamine, n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, 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Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoethanolamine, n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATE161"]}, "metabolites": {"pg161_c": -1.0, "g3pe_c": 1.0, "apg161_c": 1.0, "2agpe161_c": -1.0}, "id": "LPLIPAL2ATE161", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoethanolamine, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATE180"]}, "metabolites": {"2agpe180_c": -1.0, "apg180_c": 1.0, "pg180_c": -1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2ATE180", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoethanolamine, n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATE181"]}, "metabolites": {"apg181_c": 1.0, "2agpe181_c": -1.0, "pg181_c": -1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2ATE181", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATG120"]}, "metabolites": {"g3pg_c": 1.0, "pg120_c": -1.0, "2agpg120_c": -1.0, "apg120_c": 1.0}, "id": "LPLIPAL2ATG120", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATG140"]}, "metabolites": {"g3pg_c": 1.0, "2agpg140_c": -1.0, "apg140_c": 1.0, "pg140_c": -1.0}, "id": "LPLIPAL2ATG140", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATG141"]}, "metabolites": {"pg141_c": -1.0, "g3pg_c": 1.0, "2agpg141_c": -1.0, "apg141_c": 1.0}, "id": "LPLIPAL2ATG141", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATG160"]}, "metabolites": {"2agpg160_c": -1.0, "g3pg_c": 1.0, "apg160_c": 1.0, "pg160_c": -1.0}, "id": "LPLIPAL2ATG160", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATG161"]}, "metabolites": {"2agpg161_c": -1.0, "pg161_c": -1.0, "apg161_c": 1.0, "g3pg_c": 1.0}, "id": "LPLIPAL2ATG161", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATG180"]}, "metabolites": {"apg180_c": 1.0, "pg180_c": -1.0, "2agpg180_c": -1.0, "g3pg_c": 1.0}, "id": "LPLIPAL2ATG180", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATG181"]}, "metabolites": {"apg181_c": 1.0, "g3pg_c": 1.0, "pg181_c": -1.0, "2agpg181_c": -1.0}, "id": "LPLIPAL2ATG181", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E120"]}, "metabolites": {"ddca_c": 1.0, "h2o_c": -1.0, "2agpe120_c": -1.0, "h_c": 1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2E120", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E140"]}, "metabolites": {"h_c": 1.0, "h2o_c": -1.0, "2agpe140_c": -1.0, "ttdca_c": 1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2E140", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E141"]}, "metabolites": {"2agpe141_c": -1.0, "h2o_c": -1.0, "ttdcea_c": 1.0, "h_c": 1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2E141", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E160"]}, "metabolites": {"h2o_c": -1.0, "hdca_c": 1.0, "h_c": 1.0, "2agpe160_c": -1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2E160", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E161"]}, "metabolites": {"hdcea_c": 1.0, "h2o_c": -1.0, "g3pe_c": 1.0, "h_c": 1.0, "2agpe161_c": -1.0}, "id": "LPLIPAL2E161", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E180"]}, "metabolites": {"2agpe180_c": -1.0, "h2o_c": -1.0, "g3pe_c": 1.0, "h_c": 1.0, "ocdca_c": 1.0}, "id": "LPLIPAL2E180", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E181"]}, "metabolites": {"ocdcea_c": 1.0, "h2o_c": -1.0, "2agpe181_c": -1.0, "h_c": 1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2E181", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G120"]}, "metabolites": {"ddca_c": 1.0, "g3pg_c": 1.0, "h2o_c": -1.0, "2agpg120_c": -1.0, "h_c": 1.0}, "id": "LPLIPAL2G120", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G140"]}, "metabolites": {"g3pg_c": 1.0, "h2o_c": -1.0, "ttdca_c": 1.0, "2agpg140_c": -1.0, "h_c": 1.0}, "id": "LPLIPAL2G140", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G141"]}, "metabolites": {"g3pg_c": 1.0, "h2o_c": -1.0, "2agpg141_c": -1.0, "h_c": 1.0, "ttdcea_c": 1.0}, "id": "LPLIPAL2G141", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G160"]}, "metabolites": {"2agpg160_c": -1.0, "g3pg_c": 1.0, "h2o_c": -1.0, "hdca_c": 1.0, "h_c": 1.0}, "id": "LPLIPAL2G160", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G161"]}, "metabolites": {"hdcea_c": 1.0, "2agpg161_c": -1.0, "h2o_c": -1.0, "h_c": 1.0, "g3pg_c": 1.0}, "id": "LPLIPAL2G161", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G180"]}, "metabolites": {"g3pg_c": 1.0, "h2o_c": -1.0, "h_c": 1.0, "2agpg180_c": -1.0, "ocdca_c": 1.0}, "id": "LPLIPAL2G180", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G181"]}, "metabolites": {"ocdcea_c": 1.0, "h2o_c": -1.0, "g3pg_c": 1.0, "h_c": 1.0, "2agpg181_c": -1.0}, "id": "LPLIPAL2G181", "gene_reaction_rule": "STM3961"}, {"subsystem": "Glycine and Serine Metabolism", "name": "L-serine dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LSERDHr"]}, "metabolites": {"2amsa_c": 1.0, "ser__L_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "h_c": 1.0}, "id": "LSERDHr", "gene_reaction_rule": "STM1511"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Lysine decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSDC"]}, "metabolites": {"15dap_c": 1.0, "co2_c": 1.0, "lys__L_c": -1.0, "h_c": -1.0}, "id": "LYSDC", "gene_reaction_rule": "STM0234 or STM2559"}, {"subsystem": "tRNA Charging", "name": "Lysyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSTRS"]}, "metabolites": {"trnalys_c": -1.0, "lys__L_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "lystrna_c": 1.0}, "id": "LYSTRS", "gene_reaction_rule": "STM3040"}, {"subsystem": "Transport Inner Membrane", "name": "L-lysine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSabcpp"]}, "metabolites": {"h2o_c": -1.0, "lys__L_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "lys__L_p": -1.0, "pi_c": 1.0}, "id": "LYSabcpp", "gene_reaction_rule": "STM2355 and STM2352 and STM2351 and STM2353"}, {"subsystem": "Transport Inner Membrane", "name": "L-lysine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSt2pp"]}, "metabolites": {"lys__L_c": 1.0, "h_c": 1.0, "h_p": -1.0, "lys__L_p": -1.0}, "id": "LYSt2pp", "gene_reaction_rule": "STM2200"}, {"subsystem": "Transport Inner Membrane", "name": "L-lysine transport out via proton antiport (cytoplasm to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSt3pp"]}, "metabolites": {"lys__L_c": -1.0, "h_c": 1.0, "h_p": -1.0, "lys__L_p": 1.0}, "id": "LYSt3pp", "gene_reaction_rule": "STM3066"}, {"subsystem": "Transport Outer Membrane Porin", "name": "L-lysine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LYStex"]}, "metabolites": {"lys__L_e": -1.0, "lys__L_p": 1.0}, "id": "LYStex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Lyxose isomerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYXI"]}, "metabolites": {"xylu__L_c": 1.0, "lyx__L_c": -1.0}, "id": "LYXI", "gene_reaction_rule": "STM4046"}, {"subsystem": "Transport Inner Membrane", "name": "L-Lyxose transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYXt2pp"]}, "metabolites": {"h_p": -1.0, "lyx__L_c": 1.0, "lyx__L_p": -1.0, "h_c": 1.0}, "id": "LYXt2pp", "gene_reaction_rule": "STM4050"}, {"subsystem": "Transport Outer Membrane Porin", "name": "L-Lyxose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LYXtex"]}, "metabolites": {"lyx__L_e": -1.0, "lyx__L_p": 1.0}, "id": "LYXtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Oxidative Phosphorylation", "name": "L-Lactate dehydrogenase (ubiquinone)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["L_LACD2"]}, "metabolites": {"q8h2_c": 1.0, "pyr_c": 1.0, "lac__L_c": -1.0, "q8_c": -1.0}, "id": "L_LACD2", "gene_reaction_rule": "STM3694"}, {"subsystem": "Oxidative Phosphorylation", "name": "L-Lactate dehydrogenase (menaquinone)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["L_LACD3"]}, "metabolites": {"mqn8_c": -1.0, "pyr_c": 1.0, "lac__L_c": -1.0, "mql8_c": 1.0}, "id": "L_LACD3", "gene_reaction_rule": "STM3694"}, {"subsystem": "Transport Inner Membrane", "name": "L-lactate reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["L_LACt2rpp"]}, "metabolites": {"lac__L_c": 1.0, "h_c": 1.0, "h_p": -1.0, "lac__L_p": -1.0}, "id": "L_LACt2rpp", "gene_reaction_rule": "STM3692"}, {"subsystem": "Transport Outer Membrane Porin", "name": "L-lactate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["L_LACtex"]}, "metabolites": {"lac__L_e": -1.0, "lac__L_p": 1.0}, "id": "L_LACtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Mannitol-1-phosphate 5-dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["M1PD"]}, "metabolites": {"h_c": 1.0, "nadh_c": 1.0, "mnl1p_c": -1.0, "nad_c": -1.0, "f6p_c": 1.0}, "id": "M1PD", "gene_reaction_rule": "STM3686"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Malonyl-ACP decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MACPD"]}, "metabolites": {"acACP_c": 1.0, "co2_c": 1.0, "malACP_c": -1.0, "h_c": -1.0}, "id": "MACPD", "gene_reaction_rule": "STM2378"}, {"subsystem": "Transport Inner Membrane", "name": "D-Malate transport via proton symport (2 H) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALDt2_2pp"]}, "metabolites": {"mal__D_p": -1.0, "mal__D_c": 1.0, "h_c": 2.0, "h_p": -2.0}, "id": "MALDt2_2pp", "gene_reaction_rule": "STM3614"}, {"subsystem": "Transport Outer Membrane Porin", "name": "D-Malate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MALDtex"]}, "metabolites": {"mal__D_p": 1.0, "mal__D_e": -1.0}, "id": "MALDtex", "gene_reaction_rule": "STM1473 or STM0999 or STM2267 or STM0320"}, {"subsystem": "Anaplerotic Reactions", "name": "Malate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALS"]}, "metabolites": {"h2o_c": -1.0, "mal__L_c": 1.0, "coa_c": 1.0, "h_c": 1.0, "accoa_c": -1.0, "glx_c": -1.0}, "id": "MALS", "gene_reaction_rule": "STM4183"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltose O-acetyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MALTATr"]}, "metabolites": {"acmalt_c": 1.0, "malt_c": -1.0, "coa_c": 1.0, "accoa_c": -1.0}, "id": "MALTATr", "gene_reaction_rule": "STM0472"}, {"subsystem": "Transport Inner Membrane", "name": "Maltohexaose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTHXabcpp"]}, "metabolites": {"h2o_c": -1.0, "malthx_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "malthx_p": -1.0, "pi_c": 1.0}, "id": "MALTHXabcpp", "gene_reaction_rule": "STM4229 and STM4228 and STM4227 and STM4230"}, {"subsystem": "Transport Outer Membrane", "name": "Maltohexaose transport via diffusion (extracellular to periplasm) irreversible", "upper_bound": 1000.0, 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["MAN6Ptex"]}, "metabolites": {"man6p_p": 1.0, "man6p_e": -1.0}, "id": "MAN6Ptex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "2-O-alpha-mannosyl-D-glycerate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MANGLYCtex"]}, "metabolites": {"manglyc_e": -1.0, "manglyc_p": 1.0}, "id": "MANGLYCtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "D-mannose transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MANptspp"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "man6p_c": 1.0, "man_p": -1.0}, "id": "MANptspp", "gene_reaction_rule": "STM1830 and STM1831 and STM1832 and STM2431 and STM2432"}, {"subsystem": "Transport Outer Membrane Porin", "name": "D-mannose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MANtex"]}, "metabolites": {"man_e": -1.0, "man_p": 1.0}, "id": "MANtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-methylcitrate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MCITD"]}, "metabolites": {"2mcit_c": -1.0, "h2o_c": 1.0, "2mcacn_c": 1.0}, "id": "MCITD", "gene_reaction_rule": "STM0370"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Methylisocitrate lyase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MCITL2"]}, "metabolites": {"pyr_c": 1.0, "succ_c": 1.0, "micit_c": -1.0}, "id": "MCITL2", "gene_reaction_rule": "STM0368"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-methylcitrate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MCITS"]}, "metabolites": {"h2o_c": -1.0, "oaa_c": -1.0, "2mcit_c": 1.0, "coa_c": 1.0, "h_c": 1.0, "ppcoa_c": -1.0}, "id": "MCITS", "gene_reaction_rule": "STM0369"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Malonyl-CoA-ACP transacylase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MCOATA"]}, "metabolites": {"malACP_c": 1.0, "ACP_c": -1.0, "coa_c": 1.0, "malcoa_c": -1.0}, "id": "MCOATA", "gene_reaction_rule": "STM1196 and STM1194"}, {"subsystem": "Cysteine Metabolism", "name": "3-mercaptopyruvate sulfurtransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MCPST"]}, "metabolites": {"pyr_c": 1.0, "tcynt_c": 1.0, "h_c": 1.0, "mercppyr_c": -1.0, "cyan_c": -1.0}, "id": "MCPST", "gene_reaction_rule": "STM2533"}, {"subsystem": "Murein Biosynthesis", "name": "Murein crosslinking transpeptidase 1A:(A2pm->D-ala) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MCTP1App"]}, "metabolites": 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-1.0, "h2o_c": 1.0, "trdox_c": 1.0, "met__L_c": 1.0, "metsox_S__L_c": -1.0}, "id": "METSOXR1", "gene_reaction_rule": "(STM4408 and STM2649) or (STM4408 and STM3915)"}, {"subsystem": "Methionine Metabolism", "name": "L-methionine-R-sulfoxide reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["METSOXR2"]}, "metabolites": {"metsox_R__L_c": -1.0, "h2o_c": 1.0, "trdox_c": 1.0, "trdrd_c": -1.0, "met__L_c": 1.0}, "id": "METSOXR2", "gene_reaction_rule": "(STM1291 and STM2649) or (STM1291 and STM3915)"}, {"subsystem": "tRNA Charging", "name": "Methionyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["METTRS"]}, "metabolites": {"mettrna_c": 1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "met__L_c": -1.0, "trnamet_c": -1.0}, "id": "METTRS", "gene_reaction_rule": "STM2155"}, {"subsystem": "Transport Inner Membrane", "name": "L-methionine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["METabcpp"]}, "metabolites": {"h2o_c": -1.0, "met__L_p": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "met__L_c": 1.0}, "id": "METabcpp", "gene_reaction_rule": "STM0246 and STM0247 and STM0245"}, {"subsystem": "Transport Outer Membrane Porin", "name": "L-methionine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["METtex"]}, "metabolites": {"met__L_e": -1.0, "met__L_p": 1.0}, "id": "METtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Magnesium (Mg+2) transport in/out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MG2t3_2pp"]}, "metabolites": {"mg2_p": -1.0, "h_c": -2.0, "h_p": 2.0, "mg2_c": 1.0}, "id": "MG2t3_2pp", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "Magnesium (Mg+2) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MG2tex"]}, "metabolites": {"mg2_e": -1.0, "mg2_p": 1.0}, "id": "MG2tex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Magnesium (+2) transport in via diffusion", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MG2tpp"]}, "metabolites": {"mg2_c": 1.0, "mg2_p": -1.0}, "id": "MG2tpp", "gene_reaction_rule": "STM3952"}, {"subsystem": "Methylglyoxal Metabolism", "name": "Methylglyoxal synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MGSA"]}, "metabolites": {"dhap_c": -1.0, "pi_c": 1.0, "mthgxl_c": 1.0}, "id": "MGSA", "gene_reaction_rule": "STM1076"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Myo-inositol 1-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MI1PP"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "inost_c": 1.0, "mi1p__D_c": -1.0}, "id": "MI1PP", "gene_reaction_rule": "STM2546"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-methylisocitrate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MICITD"]}, "metabolites": {"h2o_c": -1.0, "2mcacn_c": -1.0, "micit_c": 1.0}, "id": "MICITDr", "gene_reaction_rule": "STM0158"}, {"subsystem": "Transport Outer Membrane", "name": "Myo-inositol phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MINOHPtexi"]}, "metabolites": {"minohp_p": 1.0, "minohp_e": -1.0}, "id": "MINOHPtexi", "gene_reaction_rule": ""}, {"subsystem": "Murein Biosynthesis", "name": "Murein L,D-carboxypeptidase (murein5px4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDCP1App"]}, "metabolites": {"h2o_p": -1.0, "murein3px4p_p": 1.0, "alaala_p": 1.0, "murein5px4p_p": -1.0}, "id": "MLDCP1App", "gene_reaction_rule": ""}, {"subsystem": "Murein Biosynthesis", "name": "Murein L,D-carboxypeptidase (murein4p4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDCP1Bpp"]}, "metabolites": {"h2o_p": -1.0, "ala__D_p": 1.0, "murein4p3p_p": 1.0, "murein4p4p_p": -1.0}, "id": "MLDCP1Bpp", "gene_reaction_rule": ""}, {"subsystem": "Murein Biosynthesis", "name": "Murein L,D-carboxypeptidase (murein5p5p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDCP2App"]}, "metabolites": {"h2o_p": -1.0, "murein5p3p_p": 1.0, "alaala_p": 1.0, "murein5p5p_p": -1.0}, "id": "MLDCP2App", "gene_reaction_rule": ""}, {"subsystem": "Murein Biosynthesis", "name": "Murein L,D-carboxypeptidase (murein4p3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDCP2Bpp"]}, "metabolites": {"h2o_p": -1.0, "murein3p3p_p": 1.0, "murein4p3p_p": -1.0, "ala__D_p": 1.0}, "id": "MLDCP2Bpp", "gene_reaction_rule": ""}, {"subsystem": "Murein Biosynthesis", "name": "Murein L,D-carboxypeptidase (murein5px3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDCP3App"]}, "metabolites": {"h2o_p": -1.0, "murein3px3p_p": 1.0, "murein5px3p_p": -1.0, "alaala_p": 1.0}, "id": "MLDCP3App", "gene_reaction_rule": ""}, {"subsystem": "Murein Recycling", "name": "Murein L,D-endopeptidase (murein3px3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDEP1pp"]}, "metabolites": {"h2o_p": -1.0, "murein3px3p_p": -1.0, "murein3p3p_p": 1.0}, "id": "MLDEP1pp", "gene_reaction_rule": ""}, {"subsystem": "Murein Recycling", "name": "Murein L,D-endopeptidase (murein5px3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDEP2pp"]}, "metabolites": {"h2o_p": -1.0, "murein5px3p_p": -1.0, "murein5p3p_p": 1.0}, "id": "MLDEP2pp", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltotriose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG1"]}, "metabolites": {"glc__D_c": 1.0, "h2o_c": -1.0, "malt_c": 1.0, "malttr_c": -1.0}, "id": "MLTG1", "gene_reaction_rule": "STM0401"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltotetraose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG2"]}, "metabolites": {"glc__D_c": 1.0, "h2o_c": -1.0, "malttr_c": 1.0, "maltttr_c": -1.0}, "id": "MLTG2", "gene_reaction_rule": "STM0401"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltopentaose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG3"]}, "metabolites": {"glc__D_c": 1.0, "maltpt_c": -1.0, "h2o_c": -1.0, "maltttr_c": 1.0}, "id": "MLTG3", "gene_reaction_rule": "STM0401"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltohexaose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG4"]}, "metabolites": {"maltpt_c": 1.0, "glc__D_c": 1.0, "h2o_c": -1.0, "malthx_c": -1.0}, "id": "MLTG4", "gene_reaction_rule": "STM0401"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltoheptaose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG5"]}, "metabolites": {"glc__D_c": 1.0, "malthx_c": 1.0, "h2o_c": -1.0, "malthp_c": -1.0}, "id": "MLTG5", "gene_reaction_rule": "STM0401"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein4p4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY1pp"]}, "metabolites": {"murein4p4p_p": -1.0, "anhgm4p_p": 2.0}, "id": "MLTGY1pp", "gene_reaction_rule": "STM4582 or STM2988 or STM2831 or STM1799 or STM3112"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein4p3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY2pp"]}, "metabolites": {"murein4p3p_p": -1.0, "anhgm3p_p": 1.0, "anhgm4p_p": 1.0}, "id": "MLTGY2pp", "gene_reaction_rule": "STM4582 or STM2988 or STM2831 or STM1799 or STM3112"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein3p3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY3pp"]}, "metabolites": {"murein3p3p_p": -1.0, "anhgm3p_p": 2.0}, "id": "MLTGY3pp", "gene_reaction_rule": "STM4582 or STM2988 or STM2831 or STM1799 or STM3112"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein4px4p4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY4pp"]}, "metabolites": {"murein4px4p_p": 1.0, "murein4px4p4p_p": -1.0, "anhgm4p_p": 1.0}, "id": "MLTGY4pp", "gene_reaction_rule": "STM4582 or STM2988 or STM2831 or STM1799 or STM3112"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin phosphorylase (maltopentaose)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MLTP1"]}, "metabolites": {"maltpt_c": -1.0, "pi_c": -1.0, "g1p_c": 1.0, "maltttr_c": 1.0}, "id": "MLTP1", "gene_reaction_rule": "STM3514"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin phosphorylase (maltohexaose)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MLTP2"]}, "metabolites": {"maltpt_c": 1.0, "pi_c": -1.0, "malthx_c": -1.0, "g1p_c": 1.0}, "id": "MLTP2", "gene_reaction_rule": "STM3514"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin phosphorylase (maltoheptaose)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MLTP3"]}, "metabolites": {"malthx_c": 1.0, "pi_c": -1.0, "malthp_c": -1.0, "g1p_c": 1.0}, "id": "MLTP3", "gene_reaction_rule": "STM3514"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Methylmalonyl-CoA epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MME"]}, "metabolites": {"mmcoa__S_c": 1.0, "mmcoa__R_c": -1.0}, "id": "MME", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "S-methyl-L-methionine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MMETtex"]}, "metabolites": {"mmet_e": -1.0, "mmet_p": 1.0}, "id": "MMETtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Manganese (Mn+2) transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MN2t3pp"]}, "metabolites": {"mn2_p": 1.0, "mn2_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "MN2t3pp", "gene_reaction_rule": "STM4061 or STM0758"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Manganese transport in via permease (no H+)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MN2tpp"]}, "metabolites": {"mn2_p": -1.0, "mn2_c": 1.0}, "id": "MN2tpp", "gene_reaction_rule": "STM3190"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Mannose 6-phosphate phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MN6PP"]}, "metabolites": {"h2o_c": -1.0, "man6p_c": -1.0, "pi_c": 1.0, "man_c": 1.0}, "id": "MN6PP", "gene_reaction_rule": "STM0840 or STM0842"}, {"subsystem": "Transport Inner Membrane", "name": "Mannitol transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MNLptspp"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "mnl_p": -1.0, "mnl1p_c": 1.0}, "id": "MNLptspp", "gene_reaction_rule": "STM3685 and STM2431 and STM2432"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Mannitol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MNLtex"]}, "metabolites": {"mnl_p": 1.0, "mnl_e": -1.0}, "id": "MNLtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "Manganese (Mn+2) transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MNt2pp"]}, "metabolites": {"mn2_p": -1.0, "mn2_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "MNt2pp", "gene_reaction_rule": "STM2408"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Manganese (Mn+2) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MNtex"]}, "metabolites": {"mn2_p": 1.0, "mn2_e": -1.0}, "id": "MNtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "3-deoxy-D-manno-octulosonic acid transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOAT"]}, "metabolites": {"kdolipid4_c": 1.0, "lipidA_c": -1.0, "ckdo_c": -1.0, "h_c": 1.0, "cmp_c": 1.0}, "id": "MOAT", "gene_reaction_rule": "STM3724"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "3-deoxy-D-manno-octulosonic acid transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOAT2"]}, "metabolites": {"kdo2lipid4_c": 1.0, "ckdo_c": -1.0, "cmp_c": 1.0, "h_c": 1.0, "kdolipid4_c": -1.0}, "id": "MOAT2", "gene_reaction_rule": "STM3724"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "3-deoxy-D-manno-octulosonic acid transferase III (LPS core biosynthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOAT3C"]}, "metabolites": {"ckdo_c": -1.0, "cmp_c": 1.0, "h_c": 1.0, "phphhlipa_c": -1.0, "kphphhlipa_c": 1.0}, "id": "MOAT3C", "gene_reaction_rule": "STM3715"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Molybdate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOBDabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "mobd_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "mobd_p": -1.0}, "id": "MOBDabcpp", "gene_reaction_rule": "(STM2441 and STM2444 and STM2443 and STM2442) or (STM0781 and STM0782 and STM0783) or (STM2441 and STM2443 and STM2442 and STM4063)"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Molybdate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MOBDtex"]}, "metabolites": {"mobd_e": -1.0, "mobd_p": 1.0}, "id": "MOBDtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "3-methyl-2-oxobutanoate hydroxymethyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOHMT"]}, "metabolites": {"h2o_c": -1.0, "2dhp_c": 1.0, "thf_c": 1.0, "mlthf_c": -1.0, "3mob_c": -1.0}, "id": "MOHMT", "gene_reaction_rule": "STM0182"}, {"subsystem": "Murein Biosynthesis", "name": "Murein polymerizing transglycosylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MPTG"]}, "metabolites": {"udcpdp_c": 2.0, "uaagmda_c": -2.0, "h_c": 2.0, "murein5p5p_p": 1.0}, "id": "MPTG", "gene_reaction_rule": "STM2531 or STM0190 or STM3493"}, {"subsystem": "Murein Biosynthesis", "name": "Murein polymerizing transglycosylase 2 (three linked units)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MPTG2"]}, "metabolites": {"murein5p5p5p_p": 1.0, "udcpdp_c": 1.0, "murein5p5p_p": -1.0, "h_c": 1.0, "uaagmda_c": -1.0}, "id": "MPTG2", "gene_reaction_rule": "STM0190 or STM2531 or STM3493"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Methanesulfonate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MSO3tex"]}, "metabolites": {"mso3_e": -1.0, "mso3_p": 1.0}, "id": "MSO3tex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Methylthioadenosine nucleosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MTAN"]}, "metabolites": {"5mta_c": -1.0, "h2o_c": -1.0, "ade_c": 1.0, "5mtr_c": 1.0}, "id": "MTAN", "gene_reaction_rule": "STM0207"}, {"subsystem": "Folate Metabolism", "name": "Methenyltetrahydrofolate cyclohydrolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MTHFC"]}, "metabolites": {"h2o_c": -1.0, "10fthf_c": 1.0, "h_c": 1.0, "methf_c": -1.0}, "id": "MTHFC", "gene_reaction_rule": "STM0542"}, {"subsystem": "Folate Metabolism", "name": "Methylenetetrahydrofolate dehydrogenase (NADP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MTHFD"]}, "metabolites": {"nadp_c": -1.0, "nadph_c": 1.0, "methf_c": 1.0, "mlthf_c": -1.0}, "id": "MTHFD", "gene_reaction_rule": "STM0542"}, {"subsystem": "Folate Metabolism", "name": "5,10-methylenetetrahydrofolate reductase (NADH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MTHFR2"]}, "metabolites": {"nad_c": 1.0, "nadh_c": -1.0, "5mthf_c": 1.0, "mlthf_c": -1.0, "h_c": -2.0}, "id": "MTHFR2", "gene_reaction_rule": "STM4105"}, {"subsystem": "Arginine and Proline Metabolism", "name": "5-methylthioribose-1-phosphate isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MTRI"]}, "metabolites": {"5mdru1p_c": 1.0, "5mdr1p_c": -1.0}, "id": "MTRI", "gene_reaction_rule": ""}, {"subsystem": "Arginine and Proline Metabolism", "name": "5-methylthioribose kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MTRK"]}, "metabolites": {"adp_c": 1.0, "5mtr_c": -1.0, "h_c": 1.0, "atp_c": -1.0, "5mdr1p_c": 1.0}, "id": "MTRK", "gene_reaction_rule": ""}, {"subsystem": "Glycine and Serine Metabolism", "name": "N-methyltryptophan oxidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MTRPOX"]}, "metabolites": {"o2_c": -1.0, "h2o_c": -1.0, "Nmtrp_c": -1.0, "fald_c": 1.0, "h2o2_c": 1.0, "trp__L_c": 1.0}, "id": "MTRPOX", "gene_reaction_rule": "STM1160"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Nitrious oxide transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["N2Otex"]}, "metabolites": {"n2o_p": 1.0, "n2o_e": -1.0}, "id": "N2Otex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Nitrious oxide transport (diffusion)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["N2Otpp"]}, "metabolites": {"n2o_c": 1.0, "n2o_p": -1.0}, "id": "N2Otpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Arginine and Proline Metabolism", "name": "N-acetylornithine deacetylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACODA"]}, "metabolites": {"glu5sa_c": 1.0, "h2o_c": -1.0, "ac_c": 1.0, "acg5sa_c": -1.0}, "id": "NACODA", "gene_reaction_rule": "STM4120"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Nicotinic acid transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NACtex"]}, "metabolites": {"nac_e": -1.0, "nac_p": 1.0}, "id": "NACtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "Nicotinic acid uptake (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACtpp"]}, "metabolites": {"nac_c": 1.0, "nac_p": -1.0}, "id": "NACtpp", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NAD diphosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADDP"]}, "metabolites": {"h2o_c": -1.0, "nmn_c": 1.0, "h_c": 2.0, "nad_c": -1.0, "amp_c": 1.0}, "id": "NADDP", "gene_reaction_rule": "STM2427 or STM4166"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (menaquinone-8 & 0 protons)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH10"]}, "metabolites": {"nad_c": 1.0, "nadh_c": -1.0, "mqn8_c": -1.0, "h_c": -1.0, "mql8_c": 1.0}, "id": "NADH10", "gene_reaction_rule": "STM1211"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (ubiquinone-8 & 3 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH16pp"]}, "metabolites": {"h_p": 3.0, "q8h2_c": 1.0, "h_c": -4.0, "nad_c": 1.0, "nadh_c": -1.0, "q8_c": -1.0}, "id": "NADH16pp", "gene_reaction_rule": "STM2316_S and STM2317 and STM2318 and STM2319 and STM2320 and STM2321 and STM2322 and STM2323_S and STM2324 and STM2325 and STM2326 and STM2327 and STM2328"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (menaquinone-8 & 3 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH17pp"]}, "metabolites": {"mqn8_c": -1.0, "h_p": 3.0, "h_c": -4.0, "nad_c": 1.0, "nadh_c": -1.0, "mql8_c": 1.0}, "id": "NADH17pp", "gene_reaction_rule": "STM2316_S and STM2317 and STM2318 and STM2319 and STM2320 and STM2321 and STM2322 and STM2323_S and STM2324 and STM2325 and STM2326 and STM2327 and STM2328"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (demethylmenaquinone-8 & 3 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH18pp"]}, "metabolites": {"2dmmq8_c": -1.0, "h_p": 3.0, "2dmmql8_c": 1.0, "h_c": -4.0, "nad_c": 1.0, "nadh_c": -1.0}, "id": "NADH18pp", "gene_reaction_rule": "STM2316_S and STM2317 and STM2318 and STM2319 and STM2320 and STM2321 and STM2322 and STM2323_S and STM2324 and STM2325 and STM2326 and STM2327 and STM2328"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (ubiquinone-8 )", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH5"]}, "metabolites": {"q8h2_c": 1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "q8_c": -1.0}, "id": "NADH5", "gene_reaction_rule": "STM1211"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (demethylmenaquinone-8 & 0 protons)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH9"]}, "metabolites": {"nad_c": 1.0, "nadh_c": -1.0, "h_c": -1.0, "2dmmql8_c": 1.0, "2dmmq8_c": -1.0}, "id": "NADH9", "gene_reaction_rule": "STM1211"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NAD kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADK"]}, "metabolites": {"nad_c": -1.0, "nadp_c": 1.0, "atp_c": -1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "NADK", "gene_reaction_rule": "STM2683"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NAD nucleosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADN"]}, "metabolites": {"h_c": 1.0, "h2o_c": -1.0, "adprib_c": 1.0, "nad_c": -1.0, "ncam_c": 1.0}, "id": "NADN", "gene_reaction_rule": ""}, {"subsystem": "Oxidative Phosphorylation", "name": "NADPH Quinone Reductase (Ubiquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPHQR2"]}, "metabolites": {"q8h2_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "q8_c": -1.0}, "id": "NADPHQR2", "gene_reaction_rule": "STM3179"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADPH Quinone Reductase (Menaquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPHQR3"]}, "metabolites": {"nadph_c": -1.0, "nadp_c": 1.0, "mqn8_c": -1.0, "h_c": -1.0, "mql8_c": 1.0}, "id": "NADPHQR3", "gene_reaction_rule": "STM3179"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADPH Quinone Reductase (2-Demethylmenaquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPHQR4"]}, "metabolites": {"nadp_c": 1.0, "nadph_c": -1.0, "2dmmq8_c": -1.0, "2dmmql8_c": 1.0, "h_c": -1.0}, "id": "NADPHQR4", "gene_reaction_rule": "STM3179"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NADP phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPPPS"]}, "metabolites": {"h2o_c": -1.0, "nadp_c": -1.0, "pi_c": 1.0, "nad_c": 1.0}, "id": "NADPPPS", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NAD synthase (nh3)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADS1"]}, "metabolites": {"dnad_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "nad_c": 1.0, "nh4_c": -1.0, "h_c": 1.0}, "id": "NADS1", "gene_reaction_rule": "STM1310"}, {"subsystem": "Oxidative Phosphorylation", "name": "NAD transhydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADTRHD"]}, "metabolites": {"nadp_c": 1.0, "nadph_c": -1.0, "nadh_c": 1.0, "nad_c": -1.0}, "id": "NADTRHD", "gene_reaction_rule": "STM4126 or (STM1480 and STM1479)"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Nicotinic acid mononucleotide pyrophosphorylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAMNPP"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "nicrnt_c": 1.0, "ppi_c": 1.0, "nac_c": -1.0, "adp_c": 1.0, "pi_c": 1.0, "prpp_c": -1.0}, "id": "NAMNPP", "gene_reaction_rule": "STM1004"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Sodium proton antiporter (H:NA is 1.5) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAt3_1p5pp"]}, "metabolites": {"na1_p": 2.0, "na1_c": -2.0, "h_c": 3.0, "h_p": -3.0}, "id": "NAt3_1p5pp", "gene_reaction_rule": "STM1806"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Sodium proton antiporter (H:NA is 2) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAt3_2pp"]}, "metabolites": {"na1_p": 1.0, "na1_c": -1.0, "h_c": 2.0, "h_p": -2.0}, "id": "NAt3_2pp", "gene_reaction_rule": "STM0039"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Sodium transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NAtex"]}, "metabolites": {"na1_p": 1.0, "na1_e": -1.0}, "id": "NAtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:GDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK1"]}, "metabolites": {"gdp_c": -1.0, "gtp_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "NDPK1", "gene_reaction_rule": "STM0488 or STM2526"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:UDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK2"]}, "metabolites": {"utp_c": 1.0, "udp_c": -1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "NDPK2", "gene_reaction_rule": "STM0488 or STM2526"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:CDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK3"]}, "metabolites": {"ctp_c": 1.0, "cdp_c": -1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "NDPK3", "gene_reaction_rule": "STM0488 or STM2526"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:dTDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK4"]}, "metabolites": {"dtdp_c": -1.0, "dttp_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "NDPK4", "gene_reaction_rule": "STM2526 or STM0488"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:dGDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK5"]}, "metabolites": {"dgdp_c": -1.0, "dgtp_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "NDPK5", "gene_reaction_rule": "STM2526 or STM0488"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:dUDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK6"]}, "metabolites": {"adp_c": 1.0, "dudp_c": -1.0, "atp_c": -1.0, "dutp_c": 1.0}, "id": "NDPK6", "gene_reaction_rule": "STM0488 or STM2526"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:dCDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK7"]}, "metabolites": {"dcdp_c": -1.0, "adp_c": 1.0, "atp_c": -1.0, "dctp_c": 1.0}, "id": "NDPK7", "gene_reaction_rule": "STM2526 or STM0488"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:dADP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK8"]}, "metabolites": {"datp_c": 1.0, "adp_c": 1.0, "atp_c": -1.0, "dadp_c": -1.0}, "id": "NDPK8", "gene_reaction_rule": "STM2526 or STM0488"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Ammonia transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NH4tex"]}, "metabolites": {"nh4_e": -1.0, "nh4_p": 1.0}, "id": "NH4tex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Ammonia reversible transport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NH4tpp"]}, "metabolites": {"nh4_c": 1.0, "nh4_p": -1.0}, "id": "NH4tpp", "gene_reaction_rule": "s0001 or STM0463"}, {"subsystem": "Nitrogen Metabolism", "name": "NADH:flavorubredoxin oxidoreductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NHFRBO"]}, "metabolites": {"h2o_c": 1.0, "h_c": -1.0, "nad_c": 1.0, "no_c": -2.0, "n2o_c": 1.0, "nadh_c": -1.0}, "id": "NHFRBO", "gene_reaction_rule": "STM2840 and STM2841"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Nickle (Ni+2) ABC transporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NI2abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "ni2_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "ni2_p": 1.0}, "id": "NI2abcpp", "gene_reaction_rule": "STM3576"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Nickle (Ni+2) transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": 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"id": "NMNt7pp", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "NMN transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NMNtex"]}, "metabolites": {"nmn_e": -1.0, "nmn_p": 1.0}, "id": "NMNtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Nicotinamidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NNAM"]}, "metabolites": {"h2o_c": -1.0, "ncam_c": -1.0, "nh4_c": 1.0, "nac_c": 1.0}, "id": "NNAM", "gene_reaction_rule": "STM1293"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nicotinate-nucleotide adenylyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NNATr"]}, "metabolites": {"nicrnt_c": -1.0, "dnad_c": 1.0, "ppi_c": 1.0, "h_c": -1.0, "atp_c": -1.0}, "id": "NNATr", "gene_reaction_rule": "STM0645"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Nicotinate-nucleotide diphosphorylase (carboxylating)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NNDPR"]}, "metabolites": {"nicrnt_c": 1.0, "ppi_c": 1.0, "quln_c": -1.0, "h_c": -2.0, "co2_c": 1.0, "prpp_c": -1.0}, "id": "NNDPR", "gene_reaction_rule": "STM0145"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Nitrite transport in via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NO2t2rpp"]}, "metabolites": {"h_p": -1.0, "h_c": 1.0, "no2_c": 1.0, "no2_p": -1.0}, "id": "NO2t2rpp", "gene_reaction_rule": "STM1765 or STM3476"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Nitrite transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NO2tex"]}, "metabolites": {"no2_e": -1.0, "no2_p": 1.0}, "id": "NO2tex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Nitrogen Metabolism", "name": "Nitrate reductase (Ubiquinol-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NO3R1bpp"]}, "metabolites": {"h2o_p": 1.0, "q8h2_c": -1.0, "no3_p": -1.0, "no2_p": 1.0, "q8_c": 1.0}, "id": "NO3R1bpp", "gene_reaction_rule": "STM2256 and STM2259 and STM2255 and STM2258 and STM2257"}, {"subsystem": "Oxidative Phosphorylation", "name": "Nitrate reductase (Ubiquinol-8) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NO3R1pp"]}, "metabolites": {"h2o_c": 1.0, "h_p": 2.0, "no3_c": -1.0, "q8h2_c": -1.0, "h_c": -2.0, "q8_c": 1.0, "no2_c": 1.0}, "id": "NO3R1pp", "gene_reaction_rule": "(STM1580 and STM1579 and STM1578 and STM1577) or (STM1764 and STM1763 and STM1762 and STM1761)"}, {"subsystem": "Nitrogen Metabolism", "name": "Nitrate reductase (Menaquinol-8) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NO3R2bpp"]}, "metabolites": {"h2o_p": 1.0, "no3_p": -1.0, "no2_p": 1.0, "mql8_c": -1.0, "mqn8_c": 1.0}, "id": "NO3R2bpp", "gene_reaction_rule": "STM2255 and STM2256 and STM2259 and STM2260"}, {"subsystem": "Oxidative Phosphorylation", "name": "Nitrate reductase (Menaquinol-8) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NO3R2pp"]}, "metabolites": {"h2o_c": 1.0, "mqn8_c": 1.0, "h_p": 2.0, "no3_c": -1.0, "no2_c": 1.0, "h_c": -2.0, "mql8_c": -1.0}, "id": "NO3R2pp", "gene_reaction_rule": "(STM1580 and STM1579 and STM1578 and STM1577) or (STM1764 and STM1763 and STM1762 and STM1761)"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Nitrate transport in via nitrite antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NO3t7pp"]}, "metabolites": {"no3_p": -1.0, "no2_p": 1.0, "no2_c": -1.0, "no3_c": 1.0}, "id": "NO3t7pp", "gene_reaction_rule": "STM1765 or STM1576"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Nitrate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NO3tex"]}, "metabolites": {"no3_e": -1.0, "no3_p": 1.0}, "id": "NO3tex", "gene_reaction_rule": "STM0320 or STM0999 or STM2267 or STM1473"}, {"subsystem": "Nitrogen Metabolism", "name": "Nitric oxide dioxygenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NODOx"]}, "metabolites": {"o2_c": -2.0, "no3_c": 2.0, "h_c": 1.0, "nad_c": 1.0, "no_c": -2.0, "nadh_c": -1.0}, "id": "NODOx", "gene_reaction_rule": "STM2556"}, {"subsystem": "Nitrogen Metabolism", "name": "Nitric oxide dioxygenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NODOy"]}, "metabolites": {"o2_c": -2.0, "nadp_c": 1.0, "nadph_c": -1.0, "no3_c": 2.0, "h_c": 1.0, "no_c": -2.0}, "id": "NODOy", "gene_reaction_rule": "STM2556"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Nitric oxide transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NOtex"]}, "metabolites": {"no_e": -1.0, "no_p": 1.0}, "id": "NOtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "NO transport (diffusion)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NOtpp"]}, "metabolites": {"no_p": -1.0, "no_c": 1.0}, "id": "NOtpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Naphthoate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NPHS"]}, "metabolites": {"sbzcoa_c": -1.0, "dhna_c": 1.0, "coa_c": 1.0}, "id": "NPHS", "gene_reaction_rule": "STM2307"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "5'-nucleotidase (dUMP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NTD1"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "dump_c": -1.0, "duri_c": 1.0}, "id": "NTD1", "gene_reaction_rule": "STM2332 or STM2927 or STM4559_S"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "5'-nucleotidase (XMP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NTD10"]}, "metabolites": {"xmp_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0, "xtsn_c": 1.0}, "id": "NTD10", "gene_reaction_rule": "STM2927"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "5'-nucleotidase (XMP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NTD10pp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "xmp_p": -1.0, "xtsn_p": 1.0}, "id": "NTD10pp", "gene_reaction_rule": "STM0494 or STM4249"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "5'-nucleotidase (IMP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NTD11"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "imp_c": -1.0, "ins_c": 1.0}, "id": "NTD11", "gene_reaction_rule": "STM2927"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "5'-nucleotidase (IMP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NTD11pp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "ins_p": 1.0, "imp_p": -1.0}, "id": "NTD11pp", "gene_reaction_rule": "STM4249 or STM0494"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "5'-nucleotidase (dIMP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NTD12"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "din_c": 1.0, "dimp_c": -1.0}, "id": "NTD12", "gene_reaction_rule": "STM2332 or STM2927"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "5'-nucleotidase (dIMP) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NTD12pp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "dimp_p": -1.0, "din_p": 1.0}, "id": "NTD12pp", "gene_reaction_rule": "STM0494 or STM4249"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "5'-nucleotidase (dUMP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NTD1pp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "dump_p": -1.0, "duri_p": 1.0}, "id": "NTD1pp", "gene_reaction_rule": "STM0494 or STM4249"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "5'-nucleotidase (UMP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NTD2"]}, "metabolites": {"ump_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0, "uri_c": 1.0}, "id": "NTD2", "gene_reaction_rule": "STM4559_S or STM2927"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "5'-nucleotidase (UMP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NTD2pp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "ump_p": -1.0, "uri_p": 1.0}, "id": "NTD2pp", "gene_reaction_rule": "STM4249 or STM0494"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "5'-nucleotidase (dCMP)", 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"h2o_p": -1.0, "cytd_p": 1.0, "cmp_p": -1.0}, "id": "NTD4pp", "gene_reaction_rule": "STM4249 or STM0494"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "5'-nucleotidase (dTMP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NTD5"]}, "metabolites": {"h2o_c": -1.0, "dtmp_c": -1.0, "pi_c": 1.0, "thymd_c": 1.0}, "id": "NTD5", "gene_reaction_rule": "STM2332 or STM2927 or STM4559_S"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "5'-nucleotidase (dTMP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NTD5pp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "thymd_p": 1.0, "dtmp_p": -1.0}, "id": "NTD5pp", "gene_reaction_rule": "STM0494 or STM4249"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "5'-nucleotidase (dAMP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NTD6"]}, "metabolites": {"dad_2_c": 1.0, "damp_c": -1.0, "pi_c": 1.0, "h2o_c": -1.0}, "id": "NTD6", "gene_reaction_rule": 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"Nucleotide Salvage Pathway", "name": "Nucleoside triphosphate pyrophosphorylase (dgtp)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NTPP1"]}, "metabolites": {"ppi_c": 1.0, "dgtp_c": -1.0, "dgmp_c": 1.0, "h2o_c": -1.0, "h_c": 1.0}, "id": "NTPP1", "gene_reaction_rule": "STM2954 or STM0137"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside triphosphate pyrophosphorylase (ditp)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NTPP10"]}, "metabolites": {"ditp_c": -1.0, "ppi_c": 1.0, "dimp_c": 1.0, "h2o_c": -1.0, "h_c": 1.0}, "id": "NTPP10", "gene_reaction_rule": "STM3103"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside triphosphate pyrophosphorylase (xtp)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NTPP11"]}, "metabolites": {"h_c": 1.0, "xmp_c": 1.0, "ppi_c": 1.0, "h2o_c": -1.0, "xtp_c": -1.0}, "id": "NTPP11", "gene_reaction_rule": "STM3103"}, {"subsystem": 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STM1301"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside triphosphate pyrophosphorylase (datp)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NTPP5"]}, "metabolites": {"datp_c": -1.0, "damp_c": 1.0, "ppi_c": 1.0, "h_c": 1.0, "h2o_c": -1.0}, "id": "NTPP5", "gene_reaction_rule": "STM2954 or STM1900"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside triphosphate pyrophosphorylase (atp)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NTPP6"]}, "metabolites": {"h_c": 1.0, "ppi_c": 1.0, "h2o_c": -1.0, "atp_c": -1.0, "amp_c": 1.0}, "id": "NTPP6", "gene_reaction_rule": "STM2954"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside triphosphate pyrophosphorylase (dttp)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NTPP7"]}, "metabolites": {"ppi_c": 1.0, "h2o_c": -1.0, "dtmp_c": 1.0, "dttp_c": -1.0, "h_c": 1.0}, "id": "NTPP7", "gene_reaction_rule": "STM2295 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Salvage Pathway", "name": "Nucleoside triphosphate tripolyhydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NTPTP2"]}, "metabolites": {"pppi_c": 1.0, "h2o_c": -1.0, "gtp_c": -1.0, "gsn_c": 1.0}, "id": "NTPTP2", "gene_reaction_rule": "STM0208"}, {"subsystem": "Oxidative Phosphorylation", "name": "Nitrite Reductase (NADH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NTRIR2x"]}, "metabolites": {"h2o_c": 2.0, "h_c": -5.0, "nad_c": 3.0, "nadh_c": -3.0, "nh4_c": 1.0, "no2_c": -1.0}, "id": "NTRIR2x", "gene_reaction_rule": "STM3474 and STM3475"}, {"subsystem": "Nitrogen Metabolism", "name": "Nitrite Reductase (Ubiquinole-8, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NTRIR3pp"]}, "metabolites": {"h_p": -2.0, "q8h2_c": -3.0, "no2_p": -1.0, "nh4_p": 1.0, "h2o_p": 2.0, "q8_c": 3.0}, "id": "NTRIR3pp", "gene_reaction_rule": "STM4277 and STM4278_S and STM4279 and STM4280"}, {"subsystem": "Nitrogen Metabolism", "name": "Nitrite Reductase (Menaquinole-8, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NTRIR4pp"]}, "metabolites": {"mqn8_c": 3.0, "h_p": -2.0, "no2_p": -1.0, "nh4_p": 1.0, "h2o_p": 2.0, "mql8_c": -3.0}, "id": "NTRIR4pp", "gene_reaction_rule": "STM4277 and STM4278_S and STM4279 and STM4280"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Superoxide anion transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["O2Stex"]}, "metabolites": {"o2s_p": 1.0, "o2s_e": -1.0}, "id": "O2Stex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Oxygen transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["O2tex"]}, "metabolites": {"o2_p": 1.0, "o2_e": -1.0}, "id": "O2tex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "O2 transport via diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["O2tpp"]}, "metabolites": {"o2_c": 1.0, "o2_p": -1.0}, "id": "O2tpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Pyruvate Metabolism", "name": "Oxaloacetate decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OAADC"]}, "metabolites": {"pyr_c": 1.0, "co2_c": 1.0, "h_c": -1.0, "oaa_c": -1.0}, "id": "OAADC", "gene_reaction_rule": "STM1884"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-Oxobutanoate formate lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OBTFL"]}, "metabolites": {"2obut_c": -1.0, "coa_c": -1.0, "for_c": 1.0, "ppcoa_c": 1.0}, "id": "OBTFL", "gene_reaction_rule": "((STM0970 and STM0973) and STM2646) or (STM0970 and STM0973) or (STM0970 and STM3241)"}, {"subsystem": "Transport Outer Membrane", "name": "Octadecanoate transport via facilitated irreversible diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OCDCAtexi"]}, "metabolites": {"ocdca_e": -1.0, "ocdca_p": 1.0}, "id": "OCDCAtexi", "gene_reaction_rule": "STM2391"}, {"subsystem": "Transport Outer Membrane", "name": "Octadecenoate (n-C18:1) transport via facilitated irreversible diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OCDCEAtexi"]}, "metabolites": {"ocdcea_p": 1.0, "ocdcea_e": -1.0}, "id": "OCDCEAtexi", "gene_reaction_rule": "STM2391"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Octanoate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["OCTAtex"]}, "metabolites": {"octa_e": -1.0, "octa_p": 1.0}, "id": "OCTAtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Octaprenyl pyrophosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OCTDPS"]}, "metabolites": {"ppi_c": 5.0, "ipdp_c": -5.0, "frdp_c": -1.0, "octdp_c": 1.0}, "id": "OCTDPS", "gene_reaction_rule": "STM3305"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-cis-2-trans-enoyl-CoA isomerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ODECOAI"]}, "metabolites": {"od2coa_c": 1.0, "odecoa_c": -1.0}, "id": "CTECOAI8", "gene_reaction_rule": "STM3983"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "O-Phospho-4-hydroxy-L-threonine:2-oxoglutarate aminotransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["OHPBAT"]}, "metabolites": {"akg_c": 1.0, "phthr_c": 1.0, "ohpb_c": -1.0, "glu__L_c": -1.0}, "id": "OHPBAT", "gene_reaction_rule": "STM0977"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2-octaprenyl-6-hydroxyphenol methylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OHPHM"]}, "metabolites": {"ahcys_c": 1.0, "2omph_c": 1.0, "h_c": 1.0, "2ohph_c": -1.0, "amet_c": -1.0}, "id": "OHPHM", "gene_reaction_rule": "STM2276"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2-Octaprenyl-6-methoxy-benzoquinol methylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OMBZLM"]}, "metabolites": {"2ombzl_c": -1.0, "amet_c": -1.0, "ahcys_c": 1.0, "h_c": 1.0, "2ommbl_c": 1.0}, "id": "OMBZLM", "gene_reaction_rule": "STM3970"}, {"subsystem": "Valine Leucine and Isoleucine Metabolism", "name": "2-Oxo-4-methyl-3-carboxypentanoate decarboxylation", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OMCDC"]}, "metabolites": {"3c4mop_c": -1.0, "co2_c": 1.0, "4mop_c": 1.0, "h_c": -1.0}, "id": "OMCDC", "gene_reaction_rule": "STM0112"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OMMBLHX"]}, "metabolites": {"o2_c": -0.5, "2omhmbl_c": 1.0, "2ommbl_c": -1.0}, "id": "OMMBLHX", "gene_reaction_rule": "STM0671"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase (anaerobic)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OMMBLHX3"]}, "metabolites": {"2omhmbl_c": 1.0, "nadh_c": 1.0, "adp_c": 2.0, "atp_c": -2.0, "h2o_c": -3.0, "2ommbl_c": -1.0, "h_c": 3.0, "nad_c": -1.0, "pi_c": 2.0}, "id": "OMMBLHX3", "gene_reaction_rule": ""}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Orotidine-5'-phosphate decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OMPDC"]}, "metabolites": {"ump_c": 1.0, "co2_c": 1.0, "h_c": -1.0, "orot5p_c": -1.0}, "id": "OMPDC", "gene_reaction_rule": "STM1707"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2-octaprenyl-6-methoxyphenol hydroxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OMPHHX"]}, "metabolites": {"2ombzl_c": 1.0, "o2_c": -0.5, "2omph_c": -1.0}, "id": "OMPHHX", "gene_reaction_rule": "STM3057"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2-octaprenyl-6-methoxyphenol hydroxylase (anaerobic)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OMPHHX3"]}, "metabolites": {"h2o_c": -3.0, "pi_c": 2.0, "adp_c": 2.0, "atp_c": -2.0, "2ombzl_c": 1.0, "h_c": 3.0, "nad_c": -1.0, "2omph_c": -1.0, "nadh_c": 1.0}, "id": "OMPHHX3", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Octaprenyl-hydroxybenzoate decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OPHBDC"]}, "metabolites": {"3ophb_c": -1.0, "co2_c": 1.0, "h_c": -1.0, "2oph_c": 1.0}, "id": "OPHBDC", "gene_reaction_rule": "STM3978 or STM2356"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2-Octaprenylphenol hydroxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OPHHX"]}, "metabolites": {"2oph_c": -1.0, "2ohph_c": 1.0, "o2_c": -0.5}, "id": "OPHHX", "gene_reaction_rule": "STM3972"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2-Octaprenylphenol hydroxylase (anaerobic)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OPHHX3"]}, "metabolites": {"h2o_c": -3.0, "pi_c": 2.0, "nad_c": -1.0, "2ohph_c": 1.0, "h_c": 3.0, "adp_c": 2.0, "2oph_c": -1.0, "nadh_c": 1.0, "atp_c": -2.0}, "id": "OPHHX3", "gene_reaction_rule": ""}, {"subsystem": "Arginine and Proline Metabolism", "name": "Ornithine Decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ORNDC"]}, "metabolites": {"ptrc_c": 1.0, "co2_c": 1.0, "orn_c": -1.0, "h_c": -1.0}, "id": "ORNDC", "gene_reaction_rule": "STM3114 or STM0701"}, {"subsystem": "Transport Inner Membrane", "name": "Ornithine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ORNabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "orn_p": -1.0, "orn_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "ORNabcpp", "gene_reaction_rule": "STM2355 and STM2352 and STM2351 and STM2353"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Ornithine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ORNtex"]}, "metabolites": {"orn_e": -1.0, "orn_p": 1.0}, "id": "ORNtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "Orotate transport via proton symport (2 H) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OROTt2_2pp"]}, "metabolites": {"orot_c": 1.0, "orot_p": -1.0, "h_p": -2.0, "h_c": 2.0}, "id": "OROTt2_2pp", "gene_reaction_rule": "STM3614"}, {"subsystem": "Transport Inner Membrane", "name": "Oxaloacetate transport via proton symport 2 H  periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OAAt2_2pp"]}, "metabolites": {"oaa_c": 1.0, "oaa_p": -1.0, "h_p": -2.0, "h_c": 2.0}, "id": "OAAt2_2pp", "gene_reaction_rule": "STM3614"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Orotate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["OROTtex"]}, "metabolites": {"orot_e": -1.0, "orot_p": 1.0}, "id": "OROTtex", "gene_reaction_rule": "STM1473 or STM0999 or STM0320 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Oxaloacetate transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["OAAtex"]}, "metabolites": {"oaa_e": -1.0, "oaa_p": 1.0}, "id": "OAAtex", "gene_reaction_rule": "STM1473 or STM0999 or STM0320 or STM2267"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Orotate phosphoribosyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ORPT"]}, "metabolites": {"ppi_c": -1.0, "prpp_c": 1.0, "orot_c": 1.0, "orot5p_c": -1.0}, "id": "ORPT", "gene_reaction_rule": "STM3733"}, {"subsystem": "Unassigned", "name": "Oxamate transcarbamoylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OXAMTC"]}, "metabolites": {"cbp_c": 1.0, "oxam_c": 1.0, "oxur_c": -1.0, "pi_c": -1.0}, "id": "OXAMTC", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2-oxoglutarate decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OXGDC2"]}, "metabolites": {"thmpp_c": -1.0, "akg_c": -1.0, "co2_c": 1.0, "ssaltpp_c": 1.0, "h_c": -1.0}, "id": "OXGDC2", "gene_reaction_rule": "STM2309"}, {"subsystem": "Arginine and Proline Metabolism", "name": "1-pyrroline-5-carboxylate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["P5CD"]}, "metabolites": {"h2o_c": -2.0, "glu__L_c": 1.0, "h_c": 1.0, "nad_c": -1.0, "1pyr5c_c": -1.0, "nadh_c": 1.0}, "id": "P5CD", "gene_reaction_rule": "STM1124"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Pyrroline-5-carboxylate reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["P5CR"]}, "metabolites": {"1pyr5c_c": -1.0, "pro__L_c": 1.0, "nadph_c": -1.0, "h_c": -2.0, "nadp_c": 1.0}, "id": "P5CR", "gene_reaction_rule": "STM0386"}, {"subsystem": "Transport Inner Membrane", "name": "Phosphatidate transport via ABC system (n-C12:0, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PA120abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "pa120_p": 1.0, "pa120_c": -1.0, "adp_c": 1.0, "pi_c": 1.0, "h_c": 1.0}, "id": "PA120abcpp", "gene_reaction_rule": "STM0984"}, {"subsystem": "Transport Inner Membrane", "name": "Phosphatidate transport via ABC system (n-C14:0, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PA140abcpp"]}, "metabolites": {"h2o_c": -1.0, "pa140_c": -1.0, "atp_c": -1.0, "pa140_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "PA140abcpp", "gene_reaction_rule": "STM0984"}, {"subsystem": "Transport Inner Membrane", "name": "Phosphatidate transport via ABC system (n-C14:1, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PA141abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "pa141_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "pa141_c": -1.0, "pi_c": 1.0}, "id": "PA141abcpp", "gene_reaction_rule": "STM0984"}, {"subsystem": "Transport Inner Membrane", "name": "Phosphatidate transport via ABC system (n-C16:0, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PA160abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "pa160_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "pa160_c": -1.0, "pi_c": 1.0}, "id": "PA160abcpp", "gene_reaction_rule": "STM0984"}, {"subsystem": "Transport Inner Membrane", "name": "Phosphatidate transport via ABC system (n-C16:1, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PA161abcpp"]}, "metabolites": {"h2o_c": -1.0, "pa161_p": 1.0, "atp_c": -1.0, "pa161_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "PA161abcpp", "gene_reaction_rule": "STM0984"}, {"subsystem": "Transport Inner Membrane", "name": "Phosphatidate transport via ABC system (n-C18:0, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PA180abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": 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n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PAPA120pp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "12dgr120_p": 1.0, "pa120_p": -1.0}, "id": "PAPA120pp", "gene_reaction_rule": "STM1710"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidate phosphatase (n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PAPA140"]}, "metabolites": {"h2o_c": -1.0, "pa140_c": -1.0, "pi_c": 1.0, "12dgr140_c": 1.0}, "id": "PAPA140", "gene_reaction_rule": "STM1710"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidate phosphatase (periplasmic, n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PAPA140pp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "pa140_p": -1.0, "12dgr140_p": 1.0}, "id": "PAPA140pp", "gene_reaction_rule": "STM1710"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidate phosphatase (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PAPA141"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "12dgr141_c": 1.0, "pa141_c": -1.0}, "id": "PAPA141", "gene_reaction_rule": "STM1710"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidate phosphatase (periplasmic, n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PAPA141pp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "12dgr141_p": 1.0, "pa141_p": -1.0}, "id": "PAPA141pp", "gene_reaction_rule": "STM1710"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidate phosphatase (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PAPA160"]}, "metabolites": {"pa160_c": -1.0, "h2o_c": -1.0, "12dgr160_c": 1.0, "pi_c": 1.0}, "id": "PAPA160", "gene_reaction_rule": "STM1710"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidate phosphatase (periplasmic, n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PAPA160pp"]}, "metabolites": {"12dgr160_p": 1.0, "h2o_p": -1.0, "pa160_p": -1.0, "pi_p": 1.0}, "id": "PAPA160pp", "gene_reaction_rule": "STM1710"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidate phosphatase (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PAPA161"]}, "metabolites": {"pa161_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0, "12dgr161_c": 1.0}, "id": "PAPA161", "gene_reaction_rule": "STM1710"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidate phosphatase (periplasmic, n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PAPA161pp"]}, "metabolites": {"pi_p": 1.0, "12dgr161_p": 1.0, "pa161_p": -1.0, "h2o_p": -1.0}, "id": "PAPA161pp", "gene_reaction_rule": "STM1710"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidate phosphatase (n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PAPA180"]}, "metabolites": {"12dgr180_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0, "pa180_c": -1.0}, "id": "PAPA180", "gene_reaction_rule": "STM1710"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidate phosphatase (periplasmic, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PAPA180pp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "12dgr180_p": 1.0, "pa180_p": -1.0}, "id": "PAPA180pp", "gene_reaction_rule": "STM1710"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidate phosphatase (n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PAPA181"]}, "metabolites": {"12dgr181_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0, "pa181_c": -1.0}, "id": "PAPA181", "gene_reaction_rule": "STM1710"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidate phosphatase (periplasmic, n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PAPA181pp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "12dgr181_p": 1.0, "pa181_p": -1.0}, "id": "PAPA181pp", "gene_reaction_rule": "STM1710"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Phospho-N-acetylmuramoyl-pentapeptide-transferase (meso-2,6-diaminopimelate)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PAPPT3"]}, "metabolites": {"ugmda_c": -1.0, "uagmda_c": 1.0, "ump_c": 1.0, "udcpp_c": -1.0}, "id": "PAPPT3", "gene_reaction_rule": "STM0125"}, {"subsystem": "Cysteine Metabolism", "name": "Phosphoadenylyl-sulfate reductase (thioredoxin)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PAPSR"]}, "metabolites": {"so3_c": 1.0, "pap_c": 1.0, "trdox_c": 1.0, "trdrd_c": -1.0, "paps_c": -1.0, "h_c": 2.0}, "id": "PAPSR", "gene_reaction_rule": "(STM2946 and STM2649) or (STM2946 and STM3915)"}, {"subsystem": "Cysteine Metabolism", "name": "Phosphoadenylyl-sulfate reductase (glutaredoxin)", "upper_bound": 1000.0, "lower_bound": 0.0, 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"gene_reaction_rule": ""}, {"subsystem": "Transport Inner Membrane", "name": "Phosphatidylethanolamine transport via ABC system (n-C12:0, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PE120abcpp"]}, "metabolites": {"pe120_c": -1.0, "h2o_c": -1.0, "atp_c": -1.0, "pe120_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "PE120abcpp", "gene_reaction_rule": "STM0984"}, {"subsystem": "Transport Inner Membrane", "name": "Phosphatidylethanolamine transport via ABC system (n-C14:0, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PE140abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "pe140_c": -1.0, "pe140_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "PE140abcpp", "gene_reaction_rule": "STM0984"}, {"subsystem": "Transport Inner Membrane", "name": "Phosphatidylethanolamine transport via ABC system (n-C14:1, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PE141abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "pe141_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "pe141_c": -1.0}, "id": "PE141abcpp", "gene_reaction_rule": "STM0984"}, {"subsystem": "Transport Inner Membrane", "name": "Phosphatidylethanolamine transport via ABC system (n-C16:0, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PE160abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "pe160_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "pe160_c": -1.0}, "id": "PE160abcpp", "gene_reaction_rule": "STM0984"}, {"subsystem": "Transport Inner Membrane", "name": "Phosphatidylethanolamine transport via ABC system (n-C16:1, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PE161abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "pe161_p": 1.0, "pe161_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "PE161abcpp", "gene_reaction_rule": "STM0984"}, {"subsystem": "Transport Inner 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["PGMT"]}, "metabolites": {"g6p_c": 1.0, "g1p_c": -1.0}, "id": "PGMT", "gene_reaction_rule": "STM0698 or STM2820"}, {"subsystem": "Transport Inner Membrane", "name": "Phosphatidylglycerophosphate transport via ABC system (n-C12:0, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PGP120abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "pgp120_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "pgp120_p": 1.0}, "id": "PGP120abcpp", "gene_reaction_rule": "STM0984"}, {"subsystem": "Transport Inner Membrane", "name": "Phosphatidylglycerophosphate transport via ABC system (n-C14:0, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PGP140abcpp"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "atp_c": -1.0, "pgp140_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pgp140_p": 1.0}, "id": "PGP140abcpp", "gene_reaction_rule": "STM0984"}, {"subsystem": "Transport Inner Membrane", "name": "Phosphatidylglycerophosphate transport via ABC system (n-C14:1, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PGP141abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "pgp141_p": 1.0, "pgp141_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "PGP141abcpp", "gene_reaction_rule": "STM0984"}, {"subsystem": "Transport Inner Membrane", "name": "Phosphatidylglycerophosphate transport via ABC system (n-C16:0, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PGP160abcpp"]}, "metabolites": {"pgp160_p": 1.0, "h2o_c": -1.0, "atp_c": -1.0, "pgp160_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "PGP160abcpp", "gene_reaction_rule": "STM0984"}, {"subsystem": "Transport Inner Membrane", "name": "Phosphatidylglycerophosphate transport via ABC system (n-C16:1, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PGP161abcpp"]}, "metabolites": {"h2o_c": -1.0, "pgp161_c": -1.0, "atp_c": -1.0, "pgp161_p": 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(n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PGPP120"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "pgp120_c": -1.0, "pg120_c": 1.0}, "id": "PGPP120", "gene_reaction_rule": "STM0420 or STM1710"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylglycerol phosphate phosphatase (periplasm, n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PGPP120pp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "pg120_p": 1.0, "pgp120_p": -1.0}, "id": "PGPP120pp", "gene_reaction_rule": "STM1710 or STM0420"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylglycerol phosphate phosphatase (n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PGPP140"]}, "metabolites": {"pgp140_c": -1.0, "pg140_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0}, "id": "PGPP140", "gene_reaction_rule": "STM0420 or STM1710"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylglycerol phosphate phosphatase (periplasm, n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PGPP140pp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "pg140_p": 1.0, "pgp140_p": -1.0}, "id": "PGPP140pp", "gene_reaction_rule": "STM1710 or STM0420"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylglycerol phosphate phosphatase (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PGPP141"]}, "metabolites": {"pg141_c": 1.0, "pgp141_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0}, "id": "PGPP141", "gene_reaction_rule": "STM0420 or STM1710"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylglycerol phosphate phosphatase (periplasm, n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PGPP141pp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "pgp141_p": -1.0, "pg141_p": 1.0}, "id": "PGPP141pp", "gene_reaction_rule": "STM0420 or STM1710"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylglycerol phosphate phosphatase (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PGPP160"]}, "metabolites": {"pg160_c": 1.0, "pgp160_c": -1.0, "pi_c": 1.0, "h2o_c": -1.0}, "id": "PGPP160", "gene_reaction_rule": "STM0420 or STM1710"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylglycerol phosphate phosphatase (periplasm, n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PGPP160pp"]}, "metabolites": {"pi_p": 1.0, "pgp160_p": -1.0, "pg160_p": 1.0, "h2o_p": -1.0}, "id": "PGPP160pp", "gene_reaction_rule": "STM0420 or STM1710"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylglycerol phosphate phosphatase (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PGPP161"]}, "metabolites": {"pg161_c": 1.0, "pi_c": 1.0, "h2o_c": -1.0, "pgp161_c": -1.0}, "id": "PGPP161", 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"pg180_p": 1.0, "pgp180_p": -1.0}, "id": "PGPP180pp", "gene_reaction_rule": "STM1710 or STM0420"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylglycerol phosphate phosphatase (n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PGPP181"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "pg181_c": 1.0, "pgp181_c": -1.0}, "id": "PGPP181", "gene_reaction_rule": "STM1710 or STM0420"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylglycerol phosphate phosphatase (periplasm, n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PGPP181pp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "pgp181_p": -1.0, "pg181_p": 1.0}, "id": "PGPP181pp", "gene_reaction_rule": "STM0420 or STM1710"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylglycerol synthase (n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PGSA120"]}, "metabolites": 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"metabolites": {"ppal_p": 1.0, "ppal_c": -1.0}, "id": "PPALtpp", "gene_reaction_rule": ""}, {"subsystem": "Transport Inner Membrane", "name": "Na+/Propionate symporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPAt4pp"]}, "metabolites": {"na1_p": -1.0, "ppa_p": -1.0, "ppa_c": 1.0, "na1_c": 1.0}, "id": "PPAt4pp", "gene_reaction_rule": "STM1125"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Propionate transport via diffusion", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PPAtex"]}, "metabolites": {"ppa_p": 1.0, "ppa_e": -1.0}, "id": "PPAtex", "gene_reaction_rule": "STM1473 or STM0999 or STM2267 or STM0320"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Porphobilinogen synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPBNGS"]}, "metabolites": {"ppbng_c": 1.0, "h2o_c": 2.0, "5aop_c": -2.0, "h_c": 1.0}, "id": "PPBNGS", "gene_reaction_rule": "STM0372"}, {"subsystem": "Anaplerotic Reactions", "name": "Phosphoenolpyruvate carboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPC"]}, "metabolites": {"h2o_c": -1.0, "co2_c": -1.0, "pep_c": -1.0, "h_c": 1.0, "oaa_c": 1.0, "pi_c": 1.0}, "id": "PPC", "gene_reaction_rule": "STM4119"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Phosphopantothenoylcysteine decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPCDC"]}, "metabolites": {"pan4p_c": 1.0, "co2_c": 1.0, "h_c": -1.0, "4ppcys_c": -1.0}, "id": "PPCDC", "gene_reaction_rule": "STM3730"}, {"subsystem": "Anaplerotic Reactions", "name": "Phosphoenolpyruvate carboxykinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPCK"]}, "metabolites": {"pep_c": 1.0, "co2_c": 1.0, "oaa_c": -1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "PPCK", "gene_reaction_rule": "STM3500"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPGPPDP"]}, "metabolites": {"ppi_c": 1.0, "gdp_c": 1.0, "h2o_c": -1.0, "ppgpp_c": -1.0}, "id": "PPGPPDP", "gene_reaction_rule": "STM3742"}, {"subsystem": "Oxidative Phosphorylation", "name": "Polyphosphate kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PPK2r"]}, "metabolites": {"pppi_c": 1.0, "ppi_c": -1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "PPK2r", "gene_reaction_rule": "STM2501"}, {"subsystem": "Oxidative Phosphorylation", "name": "Polyphosphate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPKr"]}, "metabolites": {"ppi_c": 1.0, "pi_c": -1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "PPKr", "gene_reaction_rule": "STM2501"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Phosphopentomutase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PPM"]}, "metabolites": {"r5p_c": 1.0, "r1p_c": -1.0}, "id": "PPM", "gene_reaction_rule": "STM4569"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Phosphopentomutase 2 (deoxyribose)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PPM2"]}, "metabolites": {"2dr1p_c": -1.0, "2dr5p_c": 1.0}, "id": "PPM2", "gene_reaction_rule": "STM4569"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Phosphopantothenate-cysteine ligase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPNCL2"]}, "metabolites": {"cys__L_c": -1.0, "cmp_c": 1.0, "ppi_c": 1.0, "4ppcys_c": 1.0, "4ppan_c": -1.0, "h_c": 1.0, "ctp_c": -1.0}, "id": "PPNCL2", "gene_reaction_rule": "STM3730"}, {"subsystem": "Tyrosine Tryptophan and Phenylalanine Metabolism", "name": "Prephenate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPND"]}, "metabolites": {"pphn_c": -1.0, "34hpp_c": 1.0, "co2_c": 1.0, "nadh_c": 1.0, "nad_c": -1.0}, "id": "PPND", "gene_reaction_rule": "STM2669"}, {"subsystem": "Tyrosine Tryptophan and Phenylalanine Metabolism", "name": "Prephenate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPNDH"]}, "metabolites": {"phpyr_c": 1.0, "h2o_c": 1.0, "co2_c": 1.0, "pphn_c": -1.0, "h_c": -1.0}, "id": "PPNDH", "gene_reaction_rule": "STM2667"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Protoporphyrinogen oxidase (aerobic)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPPGO"]}, "metabolites": {"o2_c": -1.5, "h2o_c": 3.0, "pppg9_c": -1.0, "ppp9_c": 1.0}, "id": "PPPGO", "gene_reaction_rule": "STM3987"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Protoporphyrinogen oxidase (anaerobic)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPPGO3"]}, "metabolites": 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"metabolites": {"atp_c": -1.0, "5aizc_c": -1.0, "asp__L_c": -1.0, "25aics_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "PRASCSi", "gene_reaction_rule": "STM2487"}, {"subsystem": "Histidine Metabolism", "name": "Phosphoribosyl-ATP pyrophosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PRATPP"]}, "metabolites": {"ppi_c": 1.0, "prbatp_c": -1.0, "prbamp_c": 1.0, "h2o_c": -1.0, "h_c": 1.0}, "id": "PRATPP", "gene_reaction_rule": "STM2078"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylformylglycinamidine synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PRFGS"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "glu__L_c": 1.0, "fgam_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "fpram_c": 1.0, "pi_c": 1.0, "gln__L_c": -1.0}, "id": "PRFGS", "gene_reaction_rule": "STM2565"}, {"subsystem": "Histidine Metabolism", "name": 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"atp_c": -1.0, "amp_c": 1.0}, "id": "PRPPS", "gene_reaction_rule": "STM1780"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Psicoselysine transporter via diffusion (extracellular)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PSCLYStex"]}, "metabolites": {"psclys_e": -1.0, "psclys_p": 1.0}, "id": "PSCLYStex", "gene_reaction_rule": "STM2267 or STM1473 or STM0320 or STM0999"}, {"subsystem": "Tyrosine Tryptophan and Phenylalanine Metabolism", "name": "3-phosphoshikimate 1-carboxyvinyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PSCVT"]}, "metabolites": {"pep_c": -1.0, "pi_c": 1.0, "skm5p_c": -1.0, "3psme_c": 1.0}, "id": "PSCVT", "gene_reaction_rule": "STM0978"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylserine decarboxylase (n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PSD120"]}, "metabolites": {"pe120_c": 1.0, "ps120_c": -1.0, "co2_c": 1.0, "h_c": -1.0}, "id": "PSD120", "gene_reaction_rule": "STM4348"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylserine decarboxylase (n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PSD140"]}, "metabolites": {"h_c": -1.0, "co2_c": 1.0, "ps140_c": -1.0, "pe140_c": 1.0}, "id": "PSD140", "gene_reaction_rule": "STM4348"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylserine decarboxylase (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PSD141"]}, "metabolites": {"co2_c": 1.0, "ps141_c": -1.0, "h_c": -1.0, "pe141_c": 1.0}, "id": "PSD141", "gene_reaction_rule": "STM4348"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylserine decarboxylase (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PSD160"]}, "metabolites": {"co2_c": 1.0, "pe160_c": 1.0, "h_c": -1.0, "ps160_c": -1.0}, "id": "PSD160", 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"Glycine and Serine Metabolism", "name": "Phosphoserine transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PSERT"]}, "metabolites": {"akg_c": 1.0, "3php_c": -1.0, "glu__L_c": -1.0, "pser__L_c": 1.0}, "id": "PSERT", "gene_reaction_rule": "STM0977"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Phospho-L-serine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PSERtex"]}, "metabolites": {"pser__L_p": 1.0, "pser__L_e": -1.0}, "id": "PSERtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Glycine and Serine Metabolism", "name": "Phosphoserine phosphatase (L-serine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PSP_L"]}, "metabolites": {"ser__L_c": 1.0, "h2o_c": -1.0, "pser__L_c": -1.0, "pi_c": 1.0}, "id": "PSP_L", "gene_reaction_rule": "STM4578"}, {"subsystem": "Glycine and Serine Metabolism", "name": "Phospho-L-serine phosphatase (periplasmic)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PSP_Lpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "pser__L_p": -1.0, "ser__L_p": 1.0}, "id": "PSP_Lpp", "gene_reaction_rule": "STM4249"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylserine syntase (n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PSSA120"]}, "metabolites": {"cdpdddecg_c": -1.0, "ser__L_c": -1.0, "ps120_c": 1.0, "h_c": 1.0, "cmp_c": 1.0}, "id": "PSSA120", "gene_reaction_rule": "STM2652"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylserine syntase (n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PSSA140"]}, "metabolites": {"cdpdtdecg_c": -1.0, "ser__L_c": -1.0, "cmp_c": 1.0, "h_c": 1.0, "ps140_c": 1.0}, "id": "PSSA140", "gene_reaction_rule": "STM2652"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylserine syntase (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PSSA141"]}, "metabolites": {"ser__L_c": -1.0, "cmp_c": 1.0, "ps141_c": 1.0, "h_c": 1.0, "cdpdtdec7eg_c": -1.0}, "id": "PSSA141", "gene_reaction_rule": "STM2652"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylserine syntase (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PSSA160"]}, "metabolites": {"ser__L_c": -1.0, "cmp_c": 1.0, "cdpdhdecg_c": -1.0, "h_c": 1.0, "ps160_c": 1.0}, "id": "PSSA160", "gene_reaction_rule": "STM2652"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylserine syntase (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PSSA161"]}, "metabolites": {"h_c": 1.0, "ser__L_c": -1.0, "cdpdhdec9eg_c": -1.0, "ps161_c": 1.0, "cmp_c": 1.0}, "id": "PSSA161", "gene_reaction_rule": "STM2652"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylserine syntase (n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PSSA180"]}, "metabolites": {"ps180_c": 1.0, "cdpdodecg_c": -1.0, "ser__L_c": -1.0, "h_c": 1.0, "cmp_c": 1.0}, "id": "PSSA180", "gene_reaction_rule": "STM2652"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylserine syntase (n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PSSA181"]}, "metabolites": {"ps181_c": 1.0, "ser__L_c": -1.0, "h_c": 1.0, "cdpdodec11eg_c": -1.0, "cmp_c": 1.0}, "id": "PSSA181", "gene_reaction_rule": "STM2652"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Phosphate acetyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PTA2"]}, "metabolites": {"pi_c": -1.0, "coa_c": 1.0, "ppcoa_c": -1.0, "ppap_c": 1.0}, "id": "PTA2", "gene_reaction_rule": "STM2338 or STM2047"}, {"subsystem": "Pyruvate Metabolism", "name": "Phosphotransacetylase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PTAr"]}, "metabolites": {"actp_c": 1.0, "pi_c": -1.0, "coa_c": 1.0, "accoa_c": -1.0}, "id": "PTAr", "gene_reaction_rule": "STM2338 or STM2466"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Phospho-L-threonine phosphatase (periplasmic)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PTHRpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "thrp_p": -1.0, "thr__L_p": 1.0}, "id": "PTHRpp", "gene_reaction_rule": "STM4249"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Pantetheine-phosphate adenylyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PTPATi"]}, "metabolites": {"pan4p_c": -1.0, "dpcoa_c": 1.0, "ppi_c": 1.0, "h_c": -1.0, "atp_c": -1.0}, "id": "PTPATi", "gene_reaction_rule": "STM3725"}, {"subsystem": "Transport Inner Membrane", "name": "Putrescine/ornithine antiporter (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PTRCORNt7pp"]}, "metabolites": {"ptrc_c": 1.0, "ptrc_p": -1.0, "orn_c": -1.0, "orn_p": 1.0}, "id": "PTRCORNt7pp", "gene_reaction_rule": "STM0700"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Putrescine Transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PTRCTA"]}, "metabolites": {"akg_c": -1.0, "ptrc_c": -1.0, "glu__L_c": 1.0, "4abutn_c": 1.0}, "id": "PTRCTA", "gene_reaction_rule": "STM3218"}, {"subsystem": "Transport Inner Membrane", "name": "Putrescine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PTRCabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "ptrc_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "ptrc_c": 1.0, "pi_c": 1.0}, "id": "PTRCabcpp", "gene_reaction_rule": "(STM0877 and STM0878 and STM0879 and STM0880) or (STM1226 and STM1225 and STM1223 and STM1222)"}, {"subsystem": "Transport Inner Membrane", "name": "Putrescine transport in via proton symport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PTRCt2pp"]}, "metabolites": {"ptrc_c": 1.0, "ptrc_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "PTRCt2pp", "gene_reaction_rule": "STM0700"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Putrescine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PTRCtex"]}, "metabolites": {"ptrc_p": 1.0, "ptrc_e": -1.0}, "id": "PTRCtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Purine-nucleoside phosphorylase (Adenosine)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PUNP1"]}, "metabolites": {"ade_c": 1.0, "adn_c": -1.0, "pi_c": -1.0, "r1p_c": 1.0}, "id": "PUNP1", "gene_reaction_rule": "STM4570"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Purine-nucleoside phosphorylase (Deoxyadenosine)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PUNP2"]}, "metabolites": {"dad_2_c": -1.0, "2dr1p_c": 1.0, "ade_c": 1.0, "pi_c": -1.0}, "id": "PUNP2", "gene_reaction_rule": "STM4570"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Purine-nucleoside phosphorylase (Guanosine)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PUNP3"]}, "metabolites": {"gua_c": 1.0, "pi_c": -1.0, "r1p_c": 1.0, "gsn_c": -1.0}, "id": "PUNP3", "gene_reaction_rule": "STM4570"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Purine-nucleoside phosphorylase (Deoxyguanosine)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PUNP4"]}, "metabolites": {"dgsn_c": -1.0, "2dr1p_c": 1.0, "pi_c": -1.0, "gua_c": 1.0}, "id": "PUNP4", "gene_reaction_rule": "STM2422 or STM4570"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Purine-nucleoside phosphorylase (Inosine)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PUNP5"]}, "metabolites": {"pi_c": -1.0, "hxan_c": 1.0, "r1p_c": 1.0, "ins_c": -1.0}, "id": "PUNP5", "gene_reaction_rule": "STM4570"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Purine-nucleoside phosphorylase (Deoxyinosine)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PUNP6"]}, "metabolites": {"din_c": -1.0, "2dr1p_c": 1.0, "pi_c": -1.0, "hxan_c": 1.0}, "id": "PUNP6", "gene_reaction_rule": "STM4570"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Purine-nucleoside phosphorylase (Xanthosine)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PUNP7"]}, "metabolites": {"pi_c": -1.0, "r1p_c": 1.0, "xan_c": 1.0, "xtsn_c": -1.0}, "id": "PUNP7", "gene_reaction_rule": "STM2422"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Pyridoxamine 5'-phosphate oxidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PYAM5PO"]}, "metabolites": {"o2_c": -1.0, "h2o_c": -1.0, "pydx5p_c": 1.0, "h2o2_c": 1.0, "pyam5p_c": -1.0, "nh4_c": 1.0}, "id": "PYAM5PO", "gene_reaction_rule": "STM1448"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Pyridoxamine kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PYDAMK"]}, "metabolites": {"pydam_c": -1.0, "pyam5p_c": 1.0, "atp_c": -1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "PYDAMK", "gene_reaction_rule": "STM2435"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Pyridoxal kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PYDXK"]}, "metabolites": {"h_c": 1.0, "pydx5p_c": 1.0, "atp_c": -1.0, "adp_c": 1.0, "pydx_c": -1.0}, "id": "PYDXK", "gene_reaction_rule": "STM2435 or STM1450"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Pyridoxine kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PYDXNK"]}, "metabolites": {"pydxn_c": -1.0, "pdx5p_c": 1.0, "atp_c": -1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "PYDXNK", "gene_reaction_rule": "STM2435"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Pyridoxal 5-phosphate phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PYDXPP"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "pydx5p_c": -1.0, "pydx_c": 1.0}, "id": "PYDXPP", "gene_reaction_rule": ""}, {"subsystem": "GlycolysisGluconeogenesis", "name": "Pyruvate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PYK"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "h_c": -1.0, "adp_c": -1.0, "atp_c": 1.0}, "id": "PYK", "gene_reaction_rule": "STM1888 or STM1378"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Pyrimidine-nucleoside phosphorylase (uracil)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PYNP2r"]}, "metabolites": {"uri_c": -1.0, "pi_c": -1.0, "r1p_c": 1.0, "ura_c": 1.0}, "id": "PYNP2r", "gene_reaction_rule": "STM3968"}, {"subsystem": "Transport Inner Membrane", "name": "Pyruvate reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PYRt2rpp"]}, "metabolites": {"pyr_p": -1.0, "pyr_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "PYRt2rpp", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "Pyruvate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PYRtex"]}, "metabolites": {"pyr_p": 1.0, "pyr_e": -1.0}, "id": "PYRtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Oxidative Phosphorylation", "name": "Quinol monooxygenase (Ubiquinol-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["QMO2"]}, "metabolites": {"h_c": 2.0, "o2s_c": 2.0, "q8h2_c": -1.0, "q8_c": 1.0, "o2_c": -2.0}, "id": "QMO2", "gene_reaction_rule": "STM3180"}, {"subsystem": "Oxidative Phosphorylation", "name": "Quinol monooxygenase (menaquinol 8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["QMO3"]}, "metabolites": {"o2s_c": 2.0, "mqn8_c": 1.0, "h_c": 2.0, "mql8_c": -1.0, "o2_c": -2.0}, "id": "QMO3", "gene_reaction_rule": "STM3180"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Quinolinate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["QULNS"]}, "metabolites": {"h2o_c": 2.0, "pi_c": 1.0, "quln_c": 1.0, "dhap_c": -1.0, "iasp_c": -1.0}, "id": "QULNS", "gene_reaction_rule": "STM0756"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Ribose 5-phosphate phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["R5PP"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "r5p_c": -1.0, "rib__D_c": 1.0}, "id": "R5PP", "gene_reaction_rule": "STM0840 or STM0842"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Ribose 5-phosphate phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["R5PPpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "rib__D_p": 1.0, "r5p_p": -1.0}, "id": "R5PPpp", "gene_reaction_rule": "STM4249"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Ribose 5-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["R5Ptex"]}, "metabolites": {"r5p_p": 1.0, "r5p_e": -1.0}, "id": "R5Ptex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Riboflavin kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RBFK"]}, "metabolites": {"ribflv_c": -1.0, "fmn_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "RBFK", "gene_reaction_rule": "STM0045"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Riboflavin synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RBFSa"]}, "metabolites": {"4r5au_c": -1.0, "h2o_c": 2.0, "pi_c": 1.0, "dmlz_c": 1.0, "db4p_c": -1.0}, "id": "RBFSa", "gene_reaction_rule": "STM1426"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Riboflavin synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RBFSb"]}, "metabolites": {"4r5au_c": 1.0, "dmlz_c": -2.0, "ribflv_c": 1.0}, "id": "RBFSb", "gene_reaction_rule": "STM0417"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Ribokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RBK"]}, "metabolites": {"rib__D_c": -1.0, "r5p_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "RBK", "gene_reaction_rule": "STM3885 or STM3793"}, {"subsystem": "Alternate Carbon Metabolism", "name": "L-ribulokinase (L-ribulose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RBK_L1"]}, "metabolites": {"rbl__L_c": -1.0, "adp_c": 1.0, "ru5p__L_c": 1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "RBK_L1", "gene_reaction_rule": "STM0103"}, {"subsystem": "Alternate Carbon Metabolism", "name": "L-ribulose-phosphate 4-epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["RBP4E"]}, "metabolites": {"xu5p__D_c": 1.0, "ru5p__L_c": -1.0}, "id": "RBP4E", "gene_reaction_rule": "STM0101 or STM4388 or STM3677"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Rhamnosyltransferase I (LPS core biosynthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RHAT1"]}, "metabolites": {"icolipa_c": 1.0, "dtdprmn_c": -1.0, "dtdp_c": 1.0, "h_c": 1.0, "kphphhlipa_c": -1.0}, "id": "RHAT1", "gene_reaction_rule": "STM3720"}, {"subsystem": "Methionine Metabolism", "name": "S-ribosylhomocysteine cleavage enzyme", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RHCCE"]}, "metabolites": {"hcys__L_c": 1.0, "rhcys_c": -1.0, "dhptd_c": 1.0}, "id": "RHCCE", "gene_reaction_rule": "STM2817"}, {"subsystem": "Transport Inner Membrane", "name": "D-ribose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RIBabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "rib__D_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "rib__D_c": 1.0}, "id": "RIBabcpp", "gene_reaction_rule": "STM3882 and STM3884 and STM3883 and STM3881"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Ribose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["RIBtex"]}, "metabolites": {"rib__D_e": -1.0, "rib__D_p": 1.0}, "id": "RIBtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Alternate Carbon Metabolism", "name": "L-rhamnose isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["RMI"]}, "metabolites": {"rmn_c": -1.0, "rml_c": 1.0}, "id": "RMI", "gene_reaction_rule": "STM4046"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Rhamnulokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RMK"]}, "metabolites": {"adp_c": 1.0, "rml_c": -1.0, "h_c": 1.0, "atp_c": -1.0, "rml1p_c": 1.0}, "id": "RMK", "gene_reaction_rule": "STM4047"}, {"subsystem": "Transport Outer Membrane Porin", "name": "L-rhamnose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["RMNtex"]}, "metabolites": {"rmn_p": 1.0, "rmn_e": -1.0}, "id": "RMNtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "L-rhamnose transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RMNtpp"]}, "metabolites": {"rmn_c": 1.0, "rmn_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "RMNtpp", "gene_reaction_rule": "STM4050"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Rhamnulose-1-phosphate aldolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["RMPA"]}, "metabolites": {"dhap_c": 1.0, "lald__L_c": 1.0, "rml1p_c": -1.0}, "id": "RMPA", "gene_reaction_rule": "STM4045"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Ribonucleoside-diphosphate reductase (ADP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RNDR1"]}, "metabolites": {"dadp_c": 1.0, "trdox_c": 1.0, "trdrd_c": -1.0, "adp_c": -1.0, "h2o_c": 1.0}, "id": "RNDR1", "gene_reaction_rule": "(STM2277 and STM2278) or (STM2807 and STM2808)"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Ribonucleoside-diphosphate reductase (ADP) (glutaredoxin)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RNDR1b"]}, "metabolites": {"dadp_c": 1.0, "h2o_c": 1.0, "adp_c": -1.0, "grxrd_c": -1.0, "grxox_c": 1.0}, "id": "RNDR1b", "gene_reaction_rule": "(STM1433 and (STM2807 and STM2808)) or (STM0872 and (STM2807 and STM2808)) or (STM1165 and (STM2807 and STM2808)) or (STM3702 and (STM2807 and STM2808))"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Ribonucleoside-diphosphate reductase (GDP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RNDR2"]}, "metabolites": {"h2o_c": 1.0, "dgdp_c": 1.0, "gdp_c": -1.0, "trdox_c": 1.0, "trdrd_c": -1.0}, "id": "RNDR2", "gene_reaction_rule": "(STM2277 and STM2278) or (STM2807 and STM2808)"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Ribonucleoside-diphosphate reductase (GDP) (glutaredoxin)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RNDR2b"]}, "metabolites": {"grxox_c": 1.0, "h2o_c": 1.0, "dgdp_c": 1.0, "gdp_c": -1.0, "grxrd_c": -1.0}, "id": "RNDR2b", "gene_reaction_rule": "(STM3702 and (STM2807 and STM2808)) or (STM1165 and (STM2807 and STM2808)) or (STM1433 and (STM2807 and STM2808)) or (STM0872 and (STM2807 and STM2808))"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Ribonucleoside-diphosphate reductase (CDP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RNDR3"]}, "metabolites": {"cdp_c": -1.0, "h2o_c": 1.0, "trdox_c": 1.0, "trdrd_c": -1.0, "dcdp_c": 1.0}, "id": "RNDR3", "gene_reaction_rule": "(STM2277 and STM2278) or (STM2807 and STM2808)"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Ribonucleoside-diphosphate reductase (CDP) (glutaredoxin)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RNDR3b"]}, "metabolites": {"cdp_c": -1.0, "grxox_c": 1.0, "h2o_c": 1.0, "grxrd_c": -1.0, "dcdp_c": 1.0}, "id": "RNDR3b", "gene_reaction_rule": "(STM1433 and (STM2807 and STM2808)) or (STM1165 and (STM2807 and STM2808)) or (STM0872 and (STM2807 and STM2808)) or (STM3702 and (STM2807 and STM2808))"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Ribonucleoside-diphosphate reductase (UDP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RNDR4"]}, "metabolites": {"dudp_c": 1.0, "h2o_c": 1.0, "trdox_c": 1.0, "udp_c": -1.0, "trdrd_c": -1.0}, "id": "RNDR4", "gene_reaction_rule": "(STM2277 and STM2278) or (STM2807 and STM2808)"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Ribonucleoside-diphosphate reductase (UDP) (glutaredoxin)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RNDR4b"]}, "metabolites": {"udp_c": -1.0, "grxox_c": 1.0, "h2o_c": 1.0, "dudp_c": 1.0, "grxrd_c": -1.0}, "id": "RNDR4b", "gene_reaction_rule": "(STM1165 and (STM2807 and STM2808)) or (STM3702 and (STM2807 and STM2808)) or (STM1433 and (STM2807 and STM2808)) or (STM0872 and (STM2807 and STM2808))"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Ribonucleoside-triphosphate reductase (ATP) (flavodoxin)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RNTR1c"]}, "metabolites": {"datp_c": 1.0, "fldox_c": 1.0, "fldrd_c": -1.0, "atp_c": -1.0, "h2o_c": 1.0}, "id": "RNTR1c", "gene_reaction_rule": "(STM3045 and STM4084 and STM4452 and STM4451) or (STM3045 and STM4452) or (STM0694 and STM4452) or (STM0694 and STM4084 and STM4452 and STM4451)"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Ribonucleoside-triphosphate reductase (GTP) (flavodoxin)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RNTR2c"]}, "metabolites": {"fldox_c": 1.0, "h2o_c": 1.0, "dgtp_c": 1.0, "gtp_c": -1.0, "fldrd_c": -1.0}, "id": "RNTR2c", "gene_reaction_rule": "(STM0694 and STM4452) or (STM3045 and STM4452) or (STM3045 and STM4084 and STM4452 and STM4451) or (STM0694 and STM4084 and STM4452 and STM4451)"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Ribonucleoside-triphosphate reductase (CTP) (flavodoxin)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RNTR3c"]}, "metabolites": {"ctp_c": -1.0, "fldox_c": 1.0, "h2o_c": 1.0, "fldrd_c": -1.0, "dctp_c": 1.0}, "id": "RNTR3c", "gene_reaction_rule": "(STM3045 and STM4452) or (STM0694 and STM4084 and STM4452 and STM4451) or (STM0694 and STM4452) or (STM3045 and STM4084 and STM4452 and STM4451)"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Ribonucleoside-triphosphate reductase (UTP) (flavodoxin)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RNTR4c"]}, "metabolites": {"fldox_c": 1.0, "h2o_c": 1.0, "utp_c": -1.0, "fldrd_c": -1.0, "dutp_c": 1.0}, "id": "RNTR4c", "gene_reaction_rule": "(STM0694 and STM4084 and STM4452 and STM4451) or (STM3045 and STM4452) or (STM0694 and STM4452) or (STM3045 and STM4084 and STM4452 and STM4451)"}, {"subsystem": "Pentose Phosphate Pathway", "name": "Ribulose 5-phosphate 3-epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["RPE"]}, "metabolites": {"xu5p__D_c": 1.0, "ru5p__D_c": -1.0}, "id": "RPE", "gene_reaction_rule": "STM3483 or STM4080 or STM1617"}, {"subsystem": "Pentose Phosphate Pathway", "name": "Ribose-5-phosphate isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["RPI"]}, "metabolites": {"r5p_c": -1.0, "ru5p__D_c": 1.0}, "id": "RPI", "gene_reaction_rule": "STM3063 or STM1933"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Sedoheptulose 7-phosphate isomerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["S7PI"]}, "metabolites": {"s7p_c": -1.0, "gmhep7p_c": 1.0}, "id": "S7PI", "gene_reaction_rule": "STM0310"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Succinylarginine dihydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SADH"]}, "metabolites": {"h2o_c": -2.0, "sucarg_c": -1.0, "h_c": -2.0, "sucorn_c": 1.0, "co2_c": 1.0, "nh4_c": 2.0}, "id": "SADH", "gene_reaction_rule": "STM1306"}, {"subsystem": "Cysteine Metabolism", "name": "Sulfate adenyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SADT2"]}, "metabolites": {"h2o_c": -1.0, "gdp_c": 1.0, "aps_c": 1.0, "atp_c": -1.0, "ppi_c": 1.0, "so4_c": -1.0, "gtp_c": -1.0, "pi_c": 1.0}, "id": "SADT2", "gene_reaction_rule": "STM2934 and STM2935"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Sorbitol-6-phosphate dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SBTPD"]}, "metabolites": {"h_c": 1.0, "nadh_c": 1.0, "sbt6p_c": -1.0, "nad_c": -1.0, "f6p_c": 1.0}, "id": "SBTPD", "gene_reaction_rule": "STM2835"}, {"subsystem": "Transport Inner Membrane", "name": "D-sorbitol transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SBTptspp"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "sbt__D_p": -1.0, "sbt6p_c": 1.0}, "id": "SBTptspp", "gene_reaction_rule": "STM2431 and STM2432 and STM2832 and STM2834 and STM2833"}, {"subsystem": "Transport Outer Membrane Porin", "name": "D-sorbitol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SBTtex"]}, "metabolites": {"sbt__D_e": -1.0, "sbt__D_p": 1.0}, "id": "SBTtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Succinyl-diaminopimelate desuccinylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SDPDS"]}, "metabolites": {"26dap_LL_c": 1.0, "h2o_c": -1.0, "succ_c": 1.0, "sl26da_c": -1.0}, "id": "SDPDS", "gene_reaction_rule": "STM2483"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Succinyldiaminopimelate transaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SDPTA"]}, "metabolites": {"akg_c": -1.0, "sl2a6o_c": 1.0, "sl26da_c": -1.0, "glu__L_c": 1.0}, "id": "SDPTA", "gene_reaction_rule": "STM3468"}, {"subsystem": "tRNA Charging", "name": "Selenocysteine synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SELCYSS"]}, "metabolites": {"h_c": 1.0, "sertrna_sec_c": -1.0, "pi_c": 1.0, "sectrna_c": 1.0, "selnp_c": -1.0}, "id": "SELCYSS", "gene_reaction_rule": "STM3683"}, {"subsystem": "Unassigned", "name": "Selenophosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SELNPS"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "seln_c": -1.0, "selnp_c": 1.0, "amp_c": 1.0, "pi_c": 1.0}, "id": "SELNPS", "gene_reaction_rule": "STM1297"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "(L-seryl)adenylate synthase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SERASr"]}, "metabolites": {"ser__L_c": -1.0, "ppi_c": 1.0, "seramp_c": 1.0, "h_c": -1.0, "atp_c": -1.0}, "id": "SERASr", "gene_reaction_rule": "STM0588"}, {"subsystem": "Cysteine Metabolism", "name": "Serine O-acetyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SERAT"]}, "metabolites": {"ser__L_c": -1.0, "acser_c": 1.0, "coa_c": 1.0, "accoa_c": -1.0}, "id": "SERAT", "gene_reaction_rule": "STM3699"}, {"subsystem": "Glycine and Serine Metabolism", "name": "D-serine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SERD_D"]}, "metabolites": {"pyr_c": 1.0, "ser__D_c": -1.0, "nh4_c": 1.0}, "id": "SERD_D", "gene_reaction_rule": "STM3802"}, {"subsystem": "tRNA Charging", "name": "Seryl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SERTRS"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "sertrna_c": 1.0, "ser__L_c": -1.0, "amp_c": 1.0, "trnaser_c": -1.0}, "id": "SERTRS", "gene_reaction_rule": "STM0963"}, {"subsystem": "tRNA Charging", "name": "Seryl-tRNA synthetase (selenocystein)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SERTRS2"]}, "metabolites": {"trnasecys_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "ser__L_c": -1.0, "sertrna_sec_c": 1.0, "amp_c": 1.0}, "id": "SERTRS2", "gene_reaction_rule": "STM0963"}, {"subsystem": "Transport Inner Membrane", "name": "L-serine reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SERt2rpp"]}, "metabolites": {"ser__L_p": -1.0, "ser__L_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "SERt2rpp", "gene_reaction_rule": "STM2970 or STM3243"}, {"subsystem": "Transport Inner Membrane", "name": "L-serine via sodium symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SERt4pp"]}, "metabolites": {"na1_p": -1.0, "ser__L_p": -1.0, "ser__L_c": 1.0, "na1_c": 1.0}, "id": "SERt4pp", "gene_reaction_rule": "STM3225"}, {"subsystem": "Transport Outer Membrane Porin", "name": "L-serine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SERtex"]}, "metabolites": {"ser__L_p": 1.0, "ser__L_e": -1.0}, "id": "SERtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "S-Formylglutathione hydralase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SFGTHi"]}, "metabolites": {"h2o_c": -1.0, "gthrd_c": 1.0, "h_c": 1.0, "for_c": 1.0, "Sfglutth_c": -1.0}, "id": "SFGTHi", "gene_reaction_rule": "STM2194"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Succinylglutamate desuccinylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SGDS"]}, "metabolites": {"sucglu_c": -1.0, "h2o_c": -1.0, "succ_c": 1.0, "glu__L_c": 1.0}, "id": "SGDS", "gene_reaction_rule": "STM1307"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Succinylglutamic semialdehyde dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SGSAD"]}, "metabolites": {"sucglu_c": 1.0, "h2o_c": -1.0, "sucgsa_c": -1.0, "h_c": 2.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "SGSAD", "gene_reaction_rule": "STM1305"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2-succinyl-6-hydroxy-2,4-cyclohexadiene 1-carboxylate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SHCHCS2"]}, "metabolites": {"thmpp_c": 1.0, "pyr_c": 1.0, "2shchc_c": 1.0, "ssaltpp_c": -1.0, "ichor_c": -1.0}, "id": "SHCHCS2", "gene_reaction_rule": "STM2309"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Sirohydrochlorin dehydrogenase (NAD)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SHCHD2"]}, "metabolites": {"dscl_c": -1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0, "scl_c": 1.0}, "id": "SHCHD2", "gene_reaction_rule": "STM3477"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Sirohydrochlorin ferrochelatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SHCHF"]}, "metabolites": {"fe2_c": -1.0, "sheme_c": 1.0, "scl_c": -1.0, "h_c": 3.0}, "id": "SHCHF", "gene_reaction_rule": "STM3477"}, {"subsystem": "Tyrosine Tryptophan and Phenylalanine Metabolism", "name": "Shikimate dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SHK3Dr"]}, "metabolites": {"3dhsk_c": -1.0, "skm_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0}, "id": "SHK3Dr", "gene_reaction_rule": "STM1359 or STM3401 or STM3859"}, {"subsystem": "Tyrosine Tryptophan and Phenylalanine Metabolism", "name": "Shikimate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SHKK"]}, "metabolites": {"skm5p_c": 1.0, "skm_c": -1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "SHKK", "gene_reaction_rule": "STM3487 or STM0388"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Shikimate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SKMtex"]}, "metabolites": {"skm_e": -1.0, "skm_p": 1.0}, "id": "SKMtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "SO2 transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SO2tex"]}, "metabolites": {"so2_p": 1.0, "so2_e": -1.0}, "id": "SO2tex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "SO2 transport via diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SO2tpp"]}, "metabolites": {"so2_p": -1.0, "so2_c": 1.0}, "id": "SO2tpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Sulfite transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SO3tex"]}, "metabolites": {"so3_p": 1.0, "so3_e": -1.0}, "id": "SO3tex", "gene_reaction_rule": "STM1473 or STM2267 or STM0320 or STM0999"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Sulfate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SO4tex"]}, "metabolites": {"so4_p": 1.0, "so4_e": -1.0}, "id": "SO4tex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Succinylornithine transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SOTA"]}, "metabolites": {"akg_c": -1.0, "sucorn_c": -1.0, "glu__L_c": 1.0, "sucgsa_c": 1.0}, "id": "SOTA", "gene_reaction_rule": "STM1303"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Spermidine acetyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SPMDAT1"]}, "metabolites": {"spmd_c": -1.0, "coa_c": 1.0, "h_c": 1.0, "accoa_c": -1.0, "N1aspmd_c": 1.0}, "id": "SPMDAT1", "gene_reaction_rule": "STM1502"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Spermidine acetyltransferase (N8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SPMDAT2"]}, "metabolites": {"n8aspmd_c": 1.0, "coa_c": 1.0, "spmd_c": -1.0, "accoa_c": -1.0, "h_c": 1.0}, "id": "SPMDAT2", "gene_reaction_rule": "STM1502"}, {"subsystem": "Transport Inner Membrane", "name": "Spermidine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SPMDabcpp"]}, "metabolites": {"spmd_c": 1.0, "atp_c": -1.0, "h2o_c": -1.0, "spmd_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "SPMDabcpp", "gene_reaction_rule": "STM1226 and STM1225 and STM1223 and STM1222"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Spermidine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SPMDtex"]}, "metabolites": {"spmd_p": 1.0, "spmd_e": -1.0}, "id": "SPMDtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Spermidine synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SPMS"]}, "metabolites": {"ametam_c": -1.0, "spmd_c": 1.0, "5mta_c": 1.0, "h_c": 1.0, "ptrc_c": -1.0}, "id": "SPMS", "gene_reaction_rule": "STM0166"}, {"subsystem": "Unassigned", "name": "Superoxide dismutase", "upper_bound": 0.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SPODM"]}, "metabolites": {"h2o2_c": 1.0, "o2s_c": -2.0, "h_c": -2.0, "o2_c": 1.0}, "id": "SPODM", "gene_reaction_rule": "STM4055 or STM1431"}, {"subsystem": "Unassigned", "name": "Superoxide dismutase", "upper_bound": 0.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SPODMpp"]}, "metabolites": {"o2_p": 1.0, "o2s_p": -2.0, "h2o2_p": 1.0, "h_p": -2.0}, "id": "SPODMpp", "gene_reaction_rule": "STM1440 or STM1044"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Succinate-semialdehyde dehydrogenase (NAD)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SSALx"]}, "metabolites": {"h2o_c": -1.0, "sucsal_c": -1.0, "succ_c": 1.0, "h_c": 2.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "SSALx", "gene_reaction_rule": ""}, {"subsystem": "Arginine and Proline Metabolism", "name": "Succinate-semialdehyde dehydrogenase (NADP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SSALy"]}, "metabolites": {"h2o_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "sucsal_c": -1.0, "succ_c": 1.0, "h_c": 2.0}, "id": "SSALy", "gene_reaction_rule": "STM2791"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "O-succinylbenzoate-CoA ligase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SUCBZL"]}, "metabolites": {"sucbz_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "coa_c": -1.0, "amp_c": 1.0, "sbzcoa_c": 1.0}, "id": "SUCBZL", "gene_reaction_rule": "STM2305"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "O-succinylbenzoate-CoA synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SUCBZS"]}, "metabolites": {"h2o_c": 1.0, "2shchc_c": -1.0, "sucbz_c": 1.0}, "id": "SUCBZS", "gene_reaction_rule": "STM2306"}, {"subsystem": "Transport Inner Membrane", "name": "Succinate transport via proton symport (2 H) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SUCCt2_2pp"]}, "metabolites": {"succ_p": -1.0, "succ_c": 1.0, "h_c": 2.0, "h_p": -2.0}, "id": "SUCCt2_2pp", "gene_reaction_rule": "STM3614"}, {"subsystem": "Transport Inner Membrane", "name": "Succinate transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SUCCt3pp"]}, "metabolites": {"succ_p": 1.0, "succ_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "SUCCt3pp", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "Succinate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SUCCtex"]}, "metabolites": {"succ_p": 1.0, "succ_e": -1.0}, "id": "SUCCtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Oxidative Phosphorylation", "name": "Succinate dehydrogenase (irreversible)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SUCDi"]}, "metabolites": {"q8h2_c": 1.0, "succ_c": -1.0, "fum_c": 1.0, "q8_c": -1.0}, "id": "SUCDi", "gene_reaction_rule": "STM0732 and STM0733 and STM0734 and STM0735"}, {"subsystem": "Citric Acid Cycle", "name": "Succinyl-CoA synthetase (ADP-forming)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SUCOAS"]}, "metabolites": {"atp_c": -1.0, "succoa_c": 1.0, "succ_c": -1.0, "coa_c": -1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "SUCOAS", "gene_reaction_rule": "STM0738 and STM0739"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Sucrose transport transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SUCRtex"]}, "metabolites": {"sucr_p": 1.0, "sucr_e": -1.0}, "id": "SUCRtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Sulfoaceate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SULFACtex"]}, "metabolites": {"sulfac_p": 1.0, "sulfac_e": -1.0}, "id": "SULFACtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Cysteine Metabolism", "name": "Sulfite reductase (NADPH2)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SULRi"]}, "metabolites": {"h2o_c": 3.0, "nadp_c": 3.0, "nadph_c": -3.0, "so3_c": -1.0, "h2s_c": 1.0, "h_c": -5.0}, "id": "SULRi", "gene_reaction_rule": "STM2947 and STM2948"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Sulfate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SULabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "so4_p": -1.0, "so4_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "SULabcpp", "gene_reaction_rule": "(STM2441 and STM2443 and STM2442 and STM4063) or (STM0781 and STM0782 and STM0783) or (STM2441 and STM2444 and STM2443 and STM2442)"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Trans-2-decenoyl-ACP isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["T2DECAI"]}, "metabolites": {"tdec2eACP_c": -1.0, "cdec3eACP_c": 1.0}, "id": "T2DECAI", "gene_reaction_rule": "STM1067"}, {"subsystem": "Pentose Phosphate Pathway", "name": "Transaldolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TALA"]}, "metabolites": {"s7p_c": -1.0, "e4p_c": 1.0, "g3p_c": -1.0, "f6p_c": 1.0}, "id": "TALA", "gene_reaction_rule": "STM2473 or STM0007"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Tartrate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TARTRtex"]}, "metabolites": {"tartr__L_p": 1.0, "tartr__L_e": -1.0}, "id": "TARTRtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Taurine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TAURtex"]}, "metabolites": {"taur_e": -1.0, "taur_p": 1.0}, "id": "TAURtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Thiocyanate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TCYNTtex"]}, "metabolites": {"tcynt_e": -1.0, "tcynt_p": 1.0}, "id": "TCYNTtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-cis-2-trans-enoyl-CoA isomerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TDECOAI"]}, "metabolites": {"tdecoa_c": -1.0, "td2coa_c": 1.0}, "id": "CTECOAI6", "gene_reaction_rule": "STM3983"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Thiamin pyrophosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TDP"]}, "metabolites": {"thmpp_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0, "h_c": 1.0, "thmmp_c": 1.0}, "id": "TDP", "gene_reaction_rule": "STM1235"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "DTDP-4-amino-4,6-dideoxy-D-glucose acetyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TDPADGAT"]}, "metabolites": {"dtdp4addg_c": -1.0, "dtdp4aaddg_c": 1.0, "coa_c": 1.0, "h_c": 1.0, "accoa_c": -1.0}, "id": "TDPADGAT", "gene_reaction_rule": "STM3924"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "DTDP-4-amino-4,6-dideoxy-D-glucose transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TDPAGTA"]}, "metabolites": {"akg_c": 1.0, "dtdp4addg_c": 1.0, "glu__L_c": -1.0, "dtdp4d6dg_c": -1.0}, "id": "TDPAGTA", "gene_reaction_rule": "STM3925"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "DTDP-4-dehydrorhamnose 3,5-epimerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TDPDRE"]}, "metabolites": {"dtdp4d6dm_c": 1.0, "dtdp4d6dg_c": -1.0}, "id": "TDPDRE", "gene_reaction_rule": "STM2094"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "DTDP-4-dehydrorhamnose reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TDPDRR"]}, "metabolites": {"dtdprmn_c": 1.0, "dtdp4d6dm_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0}, "id": "TDPDRR", "gene_reaction_rule": "STM2096"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "DTDPglucose 4,6-dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TDPGDH"]}, "metabolites": {"dtdpglu_c": -1.0, "h2o_c": 1.0, "dtdp4d6dg_c": 1.0}, "id": "TDPGDH", "gene_reaction_rule": "STM2097 or STM3922"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Tetraacyldisaccharide 4'kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TDSK"]}, "metabolites": {"adp_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "lipidAds_c": -1.0, "lipidA_c": 1.0}, "id": "TDSK", "gene_reaction_rule": "STM0985"}, {"subsystem": "Transport Inner Membrane", "name": "Thiol:disulfide reductase (DsbC)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TDSR1"]}, "metabolites": {"dsbcrd_p": 1.0, "dsbdox_c": 1.0, "dsbdrd_c": -1.0, "dsbcox_p": -1.0}, "id": "TDSR1", "gene_reaction_rule": "STM3043 and STM4323"}, {"subsystem": "Transport Inner Membrane", "name": "Thiol:disulfide reductase (DsbG)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TDSR2"]}, "metabolites": {"dsbgox_p": -1.0, "dsbdox_c": 1.0, "dsbdrd_c": -1.0, "dsbgrd_p": 1.0}, "id": "TDSR2", "gene_reaction_rule": "STM4323 and STM0607"}, {"subsystem": "Oxidative Phosphorylation", "name": "NAD(P) transhydrogenase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THD2pp"]}, "metabolites": {"nadp_c": -1.0, "nadph_c": 1.0, "h_p": -2.0, "h_c": 2.0, "nad_c": 1.0, "nadh_c": -1.0}, "id": "THD2pp", "gene_reaction_rule": "STM1480 and STM1479"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Tetrahydrodipicolinate succinylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THDPS"]}, "metabolites": {"thdp_c": -1.0, "succoa_c": -1.0, "h2o_c": -1.0, "coa_c": 1.0, "sl2a6o_c": 1.0}, "id": "THDPS", "gene_reaction_rule": "STM0213"}, {"subsystem": "Unassigned", "name": "Hydrogen peroxide reductase (thioredoxin)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THIORDXi"]}, "metabolites": {"h2o2_c": -1.0, "h2o_c": 2.0, "trdox_c": 1.0, "trdrd_c": -1.0}, "id": "THIORDXi", "gene_reaction_rule": "((STM0609 and STM0608) or (STM0609 and STM0402)) and (STM2649 or STM3915)"}, {"subsystem": "Transport Inner Membrane", "name": "Thymidine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THMDt2pp", "THMDt2rpp"]}, "metabolites": {"thymd_p": -1.0, "h_c": 1.0, "h_p": -1.0, "thymd_c": 1.0}, "id": "THMDt2pp_copy1", "gene_reaction_rule": "STM3113 or STM2409"}, {"subsystem": "Transport Inner Membrane", "name": "Thymidine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["THMDt2pp", "THMDt2rpp"]}, "metabolites": {"thymd_p": -1.0, "h_c": 1.0, "h_p": -1.0, "thymd_c": 1.0}, "id": "THMDt2pp_copy2", "gene_reaction_rule": "STM2421"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Thymidine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["THMDtex"]}, "metabolites": {"thymd_e": -1.0, "thymd_p": 1.0}, "id": "THMDtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "Thiamine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THMabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "thm_c": 1.0, "thm_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "THMabcpp", "gene_reaction_rule": "STM0108 and STM0107 and STM0106"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Thiamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["THMtex"]}, "metabolites": {"thm_p": 1.0, "thm_e": -1.0}, "id": "THMtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "L-allo-Threonine Aldolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THRA2i"]}, "metabolites": {"acald_c": 1.0, "gly_c": 1.0, "athr__L_c": -1.0}, "id": "THRA2i", "gene_reaction_rule": "STM2555 or STM0934"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Threonine aldolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THRAi"]}, "metabolites": {"acald_c": 1.0, "thr__L_c": -1.0, "gly_c": 1.0}, "id": "THRAi", "gene_reaction_rule": "STM2555 or STM0934"}, {"subsystem": "Glycine and Serine Metabolism", "name": "L-threonine dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THRD"]}, "metabolites": {"thr__L_c": -1.0, "nadh_c": 1.0, "2aobut_c": 1.0, "nad_c": -1.0, "h_c": 1.0}, "id": "THRD", "gene_reaction_rule": "STM3708"}, {"subsystem": "Valine Leucine and Isoleucine Metabolism", "name": "L-threonine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THRD_L"]}, "metabolites": {"thr__L_c": -1.0, "2obut_c": 1.0, "nh4_c": 1.0}, "id": "THRD_L", "gene_reaction_rule": "STM3244 or STM1826 or STM2971 or STM3905"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Phospho-L-threonine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["THRPtex"]}, "metabolites": {"thrp_e": -1.0, "thrp_p": 1.0}, "id": "THRPtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Threonine synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THRS"]}, "metabolites": {"phom_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0, "thr__L_c": 1.0}, "id": "THRS", "gene_reaction_rule": "STM0004"}, {"subsystem": "tRNA Charging", "name": "Threonyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THRTRS"]}, "metabolites": {"atp_c": -1.0, "thrtrna_c": 1.0, "ppi_c": 1.0, "amp_c": 1.0, "thr__L_c": -1.0, "trnathr_c": -1.0}, "id": "THRTRS", "gene_reaction_rule": "STM1333"}, {"subsystem": "Transport Inner Membrane", "name": "L-threonine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THRabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "thr__L_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "thr__L_c": 1.0, "pi_c": 1.0}, "id": "THRabcpp", "gene_reaction_rule": "STM3560 and STM3561 and STM3563 and STM3567 and STM3562"}, {"subsystem": "Transport Inner Membrane", "name": "L-threonine efflux transport via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THRt2pp"]}, "metabolites": {"thr__L_p": 1.0, "thr__L_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "THRt2pp", "gene_reaction_rule": "STM0832 or STM3959"}, {"subsystem": "Transport Inner Membrane", "name": "L-threonine reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["THRt2rpp"]}, "metabolites": {"thr__L_p": -1.0, "thr__L_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "THRt2rpp", "gene_reaction_rule": "STM3243"}, {"subsystem": "Transport Inner Membrane", "name": "L-threonine  via sodium symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THRt4pp"]}, "metabolites": {"na1_p": -1.0, "thr__L_p": -1.0, "thr__L_c": 1.0, "na1_c": 1.0}, "id": "THRt4pp", "gene_reaction_rule": "STM3225"}, {"subsystem": "Transport Outer Membrane Porin", "name": "L-threonine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["THRtex"]}, "metabolites": {"thr__L_p": 1.0, "thr__L_e": -1.0}, "id": "THRtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "Thymine transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THYMt3pp"]}, "metabolites": {"thym_c": -1.0, "thym_p": 1.0, "h_p": -1.0, "h_c": 1.0}, "id": "THYMt3pp", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "Thymine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["THYMtex"]}, "metabolites": {"thym_e": -1.0, "thym_p": 1.0}, "id": "THYMtex", "gene_reaction_rule": "STM1473 or STM2267 or STM0320 or STM0999"}, {"subsystem": "Pentose Phosphate Pathway", "name": "Transketolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TKT1"]}, "metabolites": {"r5p_c": -1.0, "xu5p__D_c": -1.0, "s7p_c": 1.0, "g3p_c": 1.0}, "id": "TKT1", "gene_reaction_rule": "STM3076 or STM2474 or STM2341 or STM2340"}, {"subsystem": "Pentose Phosphate Pathway", "name": "Transketolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TKT2"]}, "metabolites": {"e4p_c": -1.0, "xu5p__D_c": -1.0, "g3p_c": 1.0, "f6p_c": 1.0}, "id": "TKT2", "gene_reaction_rule": "STM3076 or STM2474 or STM2341 or STM2340"}, {"subsystem": "Oxidative Phosphorylation", "name": "Trimethylamine N-oxide reductase (menaquinol 8) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TMAOR1pp"]}, "metabolites": {"mqn8_c": 1.0, "h_p": -1.0, "tmao_p": -1.0, "tma_p": 1.0, "h2o_p": 1.0, "mql8_c": -1.0}, "id": "TMAOR1pp", "gene_reaction_rule": "STM3823 and STM3822"}, {"subsystem": "Oxidative Phosphorylation", "name": "Trimethylamine N-oxide reductase (demethylmenaquinol 8) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TMAOR2pp"]}, "metabolites": {"2dmmq8_c": 1.0, "h_p": -1.0, "tmao_p": -1.0, "2dmmql8_c": -1.0, "h2o_p": 1.0, "tma_p": 1.0}, "id": "TMAOR2pp", "gene_reaction_rule": "STM3823 and STM3822"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Trimethylamine N-oxide transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TMAOtex"]}, "metabolites": {"tmao_p": 1.0, "tmao_e": -1.0}, "id": "TMAOtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Trimethylamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TMAtex"]}, "metabolites": {"tma_e": -1.0, "tma_p": 1.0}, "id": "TMAtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Thymidine kinase (ATP:thymidine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TMDK1"]}, "metabolites": {"adp_c": 1.0, "dtmp_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "thymd_c": -1.0}, "id": "TMDK1", "gene_reaction_rule": "STM1750"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Thymidine phosphorylase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TMDPP"]}, "metabolites": {"2dr1p_c": 1.0, "pi_c": -1.0, "thym_c": 1.0, "thymd_c": -1.0}, "id": "TMDPP", "gene_reaction_rule": "STM4568"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Thymidylate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TMDS"]}, "metabolites": {"dump_c": -1.0, "dtmp_c": 1.0, "dhf_c": 1.0, "mlthf_c": -1.0}, "id": "TMDS", "gene_reaction_rule": "STM3001"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Thiamine kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TMK"]}, "metabolites": {"adp_c": 1.0, "thm_c": -1.0, "h_c": 1.0, "atp_c": -1.0, "thmmp_c": 1.0}, "id": "TMK", "gene_reaction_rule": "STM1208"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Thiamine-phosphate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TMPK"]}, "metabolites": {"thmpp_c": 1.0, "atp_c": -1.0, "adp_c": 1.0, "thmmp_c": -1.0}, "id": "TMPK", "gene_reaction_rule": "STM0419"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Thiamine-phosphate diphosphorylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TMPPP"]}, "metabolites": {"4mpetz_c": -1.0, "ppi_c": 1.0, "h_c": -1.0, "2mahmp_c": -1.0, "thmmp_c": 1.0}, "id": "TMPPP", "gene_reaction_rule": "STM4163"}, {"subsystem": "GlycolysisGluconeogenesis", "name": "Triose-phosphate isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TPI"]}, "metabolites": {"dhap_c": -1.0, "g3p_c": 1.0}, "id": "TPI", "gene_reaction_rule": "STM4081"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Triphosphoribosyl-dephospho-CoA synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TPRDCOAS"]}, "metabolites": {"2tpr3dpcoa_c": 1.0, "dpcoa_c": -1.0, "ade_c": 1.0, "atp_c": -1.0}, "id": "TPRDCOAS", "gene_reaction_rule": "STM0619"}, {"subsystem": "Oxidative Phosphorylation", "name": "Thioredoxin reductase (NADPH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRDR"]}, "metabolites": {"trdox_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "trdrd_c": 1.0, "h_c": -1.0}, "id": "TRDR", "gene_reaction_rule": "(STM3915 and (STM0958 and STM0958)) or STM2649"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Trehalose-6-phosphate hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRE6PH"]}, "metabolites": {"tre6p_c": -1.0, "glc__D_c": 1.0, "h2o_c": -1.0, "g6p_c": 1.0}, "id": "TRE6PH", "gene_reaction_rule": "STM4453"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Trehalose-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRE6PP"]}, "metabolites": {"tre_c": 1.0, "tre6p_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0}, "id": "TRE6PP", "gene_reaction_rule": "STM1929"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Alpha,alpha-trehalose-phosphate synthase (UDP-forming)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRE6PS"]}, "metabolites": {"tre6p_c": 1.0, "udp_c": 1.0, "udpg_c": -1.0, "g6p_c": -1.0, "h_c": 1.0}, "id": "TRE6PS", "gene_reaction_rule": "STM1928"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Alpha,alpha-trehalase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TREH"]}, "metabolites": {"tre_c": -1.0, "glc__D_c": 2.0, "h2o_c": -1.0}, "id": "TREH", "gene_reaction_rule": "STM3603"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Alpha,alpha-trehalase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TREHpp"]}, "metabolites": {"h2o_p": -1.0, "tre_p": -1.0, "glc__D_p": 2.0}, "id": "TREHpp", "gene_reaction_rule": "STM1796"}, {"subsystem": "Transport Inner Membrane", "name": "Trehalose transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TREptspp"]}, "metabolites": {"tre6p_c": 1.0, "pep_c": -1.0, "pyr_c": 1.0, "tre_p": -1.0}, "id": "TREptspp", "gene_reaction_rule": "STM2433 and STM2431 and STM2432 and STM4454"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Trehalose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TREtex"]}, "metabolites": {"tre_p": 1.0, "tre_e": -1.0}, "id": "TREtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Tyrosine Tryptophan and Phenylalanine Metabolism", "name": "Tryptophan synthase (indoleglycerol phosphate)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRPS1"]}, "metabolites": {"h2o_c": 1.0, "3ig3p_c": -1.0, "ser__L_c": -1.0, "trp__L_c": 1.0, "g3p_c": 1.0}, "id": "TRPS1", "gene_reaction_rule": "STM1727 and STM1726"}, {"subsystem": "Tyrosine Tryptophan and Phenylalanine Metabolism", "name": "Tryptophan synthase (indole)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRPS2"]}, "metabolites": {"h2o_c": 1.0, "ser__L_c": -1.0, "indole_c": -1.0, "trp__L_c": 1.0}, "id": "TRPS2", "gene_reaction_rule": "STM1727 and STM1726"}, {"subsystem": "Tyrosine Tryptophan and Phenylalanine Metabolism", "name": "Tryptophan synthase (indoleglycerol phosphate)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRPS3"]}, "metabolites": {"3ig3p_c": -1.0, "g3p_c": 1.0, "indole_c": 1.0}, "id": "TRPS3", "gene_reaction_rule": "STM1727 and STM1726"}, {"subsystem": "tRNA Charging", "name": "Tryptophanyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRPTRS"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "trnatrp_c": -1.0, "amp_c": 1.0, "trptrna_c": 1.0, "trp__L_c": -1.0}, "id": "TRPTRS", "gene_reaction_rule": "STM3481"}, {"subsystem": "Transport Inner Membrane", "name": "L-tryptophan reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TRPt2rpp"]}, "metabolites": {"trp__L_c": 1.0, "trp__L_p": -1.0, "h_p": -1.0, "h_c": 1.0}, "id": "TRPt2rpp", "gene_reaction_rule": "STM0150 or STM3279"}, {"subsystem": "Transport Outer Membrane Porin", "name": "L-tryptophan transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TRPtex"]}, "metabolites": {"trp__L_e": -1.0, "trp__L_p": 1.0}, "id": "TRPtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Tartronate semialdehyde reductase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TRSARr"]}, "metabolites": {"nadh_c": -1.0, "glyc__R_c": 1.0, "2h3oppan_c": -1.0, "nad_c": 1.0, "h_c": -1.0}, "id": "TRSARr", "gene_reaction_rule": "STM0519 or STM3248"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Thiosulfate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TSULabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "tsul_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "tsul_c": 1.0}, "id": "TSULabcpp", "gene_reaction_rule": "(STM2441 and STM2444 and STM2443 and STM2442) or (STM2441 and STM2443 and STM2442 and STM4063)"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Thiosulfate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TSULtex"]}, "metabolites": {"tsul_e": -1.0, "tsul_p": 1.0}, "id": "TSULtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane", "name": "Tetradecanoate transport via facilitated irreversible diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TTDCAtexi"]}, "metabolites": {"ttdca_e": -1.0, "ttdca_p": 1.0}, "id": "TTDCAtexi", "gene_reaction_rule": "STM2391"}, {"subsystem": "Transport Outer Membrane", "name": "Tetradecenoate transport via facilitated irreversible diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TTDCEAtexi"]}, "metabolites": {"ttdcea_e": -1.0, "ttdcea_p": 1.0}, "id": "TTDCEAtexi", "gene_reaction_rule": "STM2391"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Tungstate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TUNGSabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "tungs_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "tungs_p": -1.0}, "id": "TUNGSabcpp", "gene_reaction_rule": "STM0781 and STM0782 and STM0783"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Tungstate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TUNGStex"]}, "metabolites": {"tungs_e": -1.0, "tungs_p": 1.0}, "id": "TUNGStex", "gene_reaction_rule": "STM2267 or STM1473 or STM0320 or STM0999"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Tyramine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TYMtex"]}, "metabolites": {"tym_e": -1.0, "tym_p": 1.0}, "id": "TYMtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Tyrosine Tryptophan and Phenylalanine Metabolism", "name": "Phospho-L-tyrosine phosphatase (periplasmic)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TYRPpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "tyr__L_p": 1.0, "tyrp_p": -1.0}, "id": "TYRPpp", "gene_reaction_rule": "STM4249"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Phopho-L-tyrosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TYRPtex"]}, "metabolites": {"tyrp_p": 1.0, "tyrp_e": -1.0}, "id": "TYRPtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Tyrosine Tryptophan and Phenylalanine Metabolism", "name": "Tyrosine transaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TYRTA"]}, "metabolites": {"akg_c": -1.0, "34hpp_c": 1.0, "glu__L_c": 1.0, "tyr__L_c": -1.0}, "id": "TYRTA", "gene_reaction_rule": "STM4248 or STM0998"}, {"subsystem": "tRNA charging", "name": "Tyrosyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TYRTRS"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "tyrtrna_c": 1.0, "trnatyr_c": -1.0, "amp_c": 1.0, "tyr__L_c": -1.0}, "id": "TYRTRS", "gene_reaction_rule": "STM1449"}, {"subsystem": "Transport Inner Membrane", "name": "L-tyrosine reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TYRt2rpp"]}, "metabolites": {"tyr__L_p": -1.0, "h_c": 1.0, "h_p": -1.0, "tyr__L_c": 1.0}, "id": "TYRt2rpp", "gene_reaction_rule": "STM1937 or STM0150 or STM0568"}, {"subsystem": "Transport Outer Membrane Porin", "name": "L-tyrosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TYRtex"]}, "metabolites": {"tyr__L_e": -1.0, "tyr__L_p": 1.0}, "id": "TYRtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "UDP-3-O-(3-hydroxymyristoyl)glucosamine acyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["U23GAAT"]}, "metabolites": {"u3hga_c": -1.0, "u23ga_c": 1.0, "ACP_c": 1.0, "h_c": 1.0, "3hmrsACP_c": -1.0}, "id": "U23GAAT", "gene_reaction_rule": "STM0226"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UAAGDS"]}, "metabolites": {"26dap__M_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "uamag_c": -1.0, "ugmd_c": 1.0}, "id": "UAAGDS", "gene_reaction_rule": "STM0123"}, {"subsystem": "Alternate Carbon Metabolism", "name": "UDP-N-acetyl-D-galactosamine pyrophosphohydrolase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UACGALPpp"]}, "metabolites": {"h2o_p": -1.0, "ump_p": 1.0, "acgal1p_p": 1.0, "udpacgal_p": -1.0, "h_p": 2.0}, "id": "UACGALPpp", "gene_reaction_rule": "STM0494"}, {"subsystem": "Alternate Carbon Metabolism", "name": "UDP-N-acetyl-D-glucosamine pyrophosphohydrolase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UACGAMPpp"]}, "metabolites": {"h2o_p": -1.0, "ump_p": 1.0, "uacgam_p": -1.0, "acgam1p_p": 1.0, "h_p": 2.0}, "id": "UACGAMPpp", "gene_reaction_rule": "STM0494"}, {"subsystem": "Transport Outer Membrane Porin", "name": "UDP-N-acetyl-D-glucosamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UACGAMtex"]}, "metabolites": {"uacgam_p": 1.0, "uacgam_e": -1.0}, "id": "UACGAMtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetyl-D-mannosamine oxidoreductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UACMAMO"]}, "metabolites": {"uacmam_c": -1.0, "uacmamu_c": 1.0, "h2o_c": -1.0, "h_c": 3.0, "nad_c": -2.0, "nadh_c": 2.0}, "id": "UACMAMO", "gene_reaction_rule": "STM3921"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylglucosamine 2-epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UAG2E"]}, "metabolites": {"uacgam_c": -1.0, "uacmam_c": 1.0}, "id": "UAG2E", "gene_reaction_rule": "STM3920"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "UDP-N-acetylglucosamine acyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UAGAAT"]}, "metabolites": {"uacgam_c": -1.0, "u3aga_c": 1.0, "ACP_c": 1.0, "3hmrsACP_c": -1.0}, "id": "UAGAAT", "gene_reaction_rule": "STM1196 and STM0228"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylglucosamine 1-carboxyvinyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UAGCVT"]}, "metabolites": {"pep_c": -1.0, "uacgam_c": -1.0, "uaccg_c": 1.0, "pi_c": 1.0}, "id": "UAGCVT", "gene_reaction_rule": "STM3307"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylglucosamine diphosphorylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UAGDP"]}, "metabolites": {"uacgam_c": 1.0, "utp_c": -1.0, "ppi_c": 1.0, "h_c": -1.0, "acgam1p_c": -1.0}, "id": "UAGDP", "gene_reaction_rule": "STM3862"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UAGPT3"]}, "metabolites": {"uacgam_c": -1.0, "uaagmda_c": 1.0, "udp_c": 1.0, "uagmda_c": -1.0, "h_c": 1.0}, "id": "UAGPT3", "gene_reaction_rule": "STM0128"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UAMAGS"]}, "metabolites": {"glu__D_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "uama_c": -1.0, "uamag_c": 1.0}, "id": "UAMAGS", "gene_reaction_rule": "STM0126"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylmuramoyl-L-alanine synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UAMAS"]}, "metabolites": {"atp_c": -1.0, "uamr_c": -1.0, "ala__L_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "uama_c": 1.0}, "id": "UAMAS", "gene_reaction_rule": "STM0129"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylenolpyruvoylglucosamine reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UAPGR"]}, "metabolites": {"uamr_c": 1.0, "uaccg_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0}, "id": "UAPGR", "gene_reaction_rule": "STM4137"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Undecaprenyl-diphosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UDCPDP"]}, "metabolites": {"udcpdp_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0, "h_c": 1.0, "udcpp_c": 1.0}, "id": "UDCPDP", "gene_reaction_rule": "STM1710 or STM0865 or STM3205"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Undecaprenyl diphosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UDCPDPS"]}, "metabolites": {"udcpdp_c": 1.0, "ppi_c": 8.0, "ipdp_c": -8.0, "frdp_c": -1.0}, "id": "UDCPDPS", "gene_reaction_rule": "STM0221"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Undecaprenyl-diphosphatase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UDCPDPpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "udcpdp_p": -1.0, "udcpp_p": 1.0, "h_p": 1.0}, "id": "UDCPDPpp", "gene_reaction_rule": "STM0865 or STM1710 or STM3205"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Undecaprenyl phosphate transport (cytoplasm to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UDCPPtppi"]}, "metabolites": {"udcpp_p": -1.0, "udcpp_c": 1.0}, "id": "UDCPPtppi", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "UDP-N-acetyl-D-galactosamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UDPACGALtex"]}, "metabolites": {"udpacgal_e": -1.0, "udpacgal_p": 1.0}, "id": "UDPACGALtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Alternate Carbon Metabolism", "name": "UDPglucose 4-epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UDPG4E"]}, "metabolites": {"udpgal_c": 1.0, "udpg_c": -1.0}, "id": "UDPG4E", "gene_reaction_rule": "STM0776"}, {"subsystem": "Alternate Carbon Metabolism", "name": "UDPgalactose pyrophosphohydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UDPGALPpp"]}, "metabolites": {"h2o_p": -1.0, "udpgal_p": -1.0, "ump_p": 1.0, "h_p": 2.0, "gal1p_p": 1.0}, "id": "UDPGALPpp", "gene_reaction_rule": "STM0494"}, {"subsystem": "Transport Outer Membrane Porin", "name": "UDPgalactose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UDPGALtex"]}, "metabolites": {"udpgal_p": 1.0, "udpgal_e": -1.0}, "id": "UDPGALtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDPglucose 6-dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UDPGD"]}, "metabolites": {"h2o_c": -1.0, "udpglcur_c": 1.0, "h_c": 3.0, "nad_c": -2.0, "nadh_c": 2.0, "udpg_c": -1.0}, "id": "UDPGD", "gene_reaction_rule": "STM2080"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "UDP-glucuronate C-4'' decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UDPGDC"]}, "metabolites": {"udpLa4o_c": 1.0, "nadh_c": 1.0, "co2_c": 1.0, "udpglcur_c": -1.0, "nad_c": -1.0}, "id": "UDPGDC", "gene_reaction_rule": "STM2299"}, {"subsystem": "Transport Outer Membrane Porin", "name": "UDP-D-glucuronate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UDPGLCURtex"]}, "metabolites": {"udpglcur_e": -1.0, "udpglcur_p": 1.0}, "id": "UDPGLCURtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Alternate Carbon Metabolism", "name": "UDPglucose pyrophosphohydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UDPGPpp"]}, "metabolites": {"h2o_p": -1.0, "ump_p": 1.0, "g1p_p": 1.0, "h_p": 2.0, "udpg_p": -1.0}, "id": "UDPGPpp", "gene_reaction_rule": "STM0494"}, {"subsystem": "Transport Outer Membrane Porin", "name": "UDPglucose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UDPGtex"]}, "metabolites": {"udpg_e": -1.0, "udpg_p": 1.0}, "id": "UDPGtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "UDP-4''-ketopentose:UDP-4-amino-4-deoxy-L-arabinose aminotransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UDPKAAT"]}, "metabolites": {"akg_c": 1.0, "glu__L_c": -1.0, "udpLa4o_c": -1.0, "udpLa4n_c": 1.0}, "id": "UDPKAAT", "gene_reaction_rule": "STM2297"}, {"subsystem": "Alternate Carbon 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"name": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UGMDDS"]}, "metabolites": {"atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "ugmda_c": 1.0, "pi_c": 1.0, "alaala_c": -1.0, "ugmd_c": -1.0}, "id": "UGMDDS", "gene_reaction_rule": "STM0124"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "UDP-3-O-acetylglucosamine deacetylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UHGADA"]}, "metabolites": {"u3aga_c": -1.0, "u3hga_c": 1.0, "h2o_c": -1.0, "ac_c": 1.0}, "id": "UHGADA", "gene_reaction_rule": "STM0134"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "UDP-L-Ara4N formyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ULA4NFT"]}, "metabolites": {"udpLa4fn_c": 1.0, "thf_c": 1.0, "udpLa4n_c": -1.0, "h_c": 1.0, "10fthf_c": -1.0}, "id": "ULA4NFT", 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"ump_e": -1.0}, "id": "UMPtex", "gene_reaction_rule": "STM0999 or STM1473 or STM2267 or STM0320"}, {"subsystem": "Arginine and Proline Metabolism", "name": "2-keto-4-methylthiobutyrate transamination", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UNK3"]}, "metabolites": {"akg_c": 1.0, "glu__L_c": -1.0, "2kmb_c": -1.0, "met__L_c": 1.0}, "id": "UNK3", "gene_reaction_rule": "STM4248"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Undecaprenyl phosphate-L-Ara4FN formylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UPLA4FNF"]}, "metabolites": {"h2o_c": -1.0, "for_c": 1.0, "uLa4fn_c": -1.0, "uLa4n_c": 1.0}, "id": "UPLA4FNF", "gene_reaction_rule": ""}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Undecaprenyl phosphate-L-Ara4FN transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UPLA4FNT"]}, "metabolites": {"udpLa4fn_c": -1.0, "udp_c": 1.0, 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"STM0528"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Urea transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UREAtex"]}, "metabolites": {"urea_p": 1.0, "urea_e": -1.0}, "id": "UREAtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "Urea transport via facilitate diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UREAtpp"]}, "metabolites": {"urea_p": -1.0, "urea_c": 1.0}, "id": "UREAtpp", "gene_reaction_rule": "STM4087"}, {"subsystem": "Unassigned", "name": "Uricase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["URIC"]}, "metabolites": {"o2_c": -1.0, "h2o_c": -2.0, "urate_c": -1.0, "h2o2_c": 1.0, "co2_c": 1.0, "alltn_c": 1.0}, "id": "URIC", "gene_reaction_rule": ""}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Uridylate kinase (dUMP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["URIDK2r"]}, "metabolites": {"dump_c": -1.0, "dudp_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "URIDK2r", "gene_reaction_rule": "STM0218"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Uridine hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["URIH"]}, "metabolites": {"uri_c": -1.0, "h2o_c": -1.0, "rib__D_c": 1.0, "ura_c": 1.0}, "id": "URIH", "gene_reaction_rule": "STM0661 or STM0051"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Uridine kinase (GTP:Uridine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["URIK2"]}, "metabolites": {"uri_c": -1.0, "gtp_c": -1.0, "h_c": 1.0, "ump_c": 1.0, "gdp_c": 1.0}, "id": "URIK2", "gene_reaction_rule": "STM2122"}, {"subsystem": "Transport Inner Membrane", "name": "Uridine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["URIt2pp", "URIt2rpp"]}, "metabolites": {"uri_c": 1.0, "uri_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "URIt2pp_copy1", "gene_reaction_rule": "STM3113 or STM2409"}, {"subsystem": "Transport Inner Membrane", "name": "Uridine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["URIt2pp", "URIt2rpp"]}, "metabolites": {"uri_c": 1.0, "uri_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "URIt2pp_copy2", "gene_reaction_rule": "STM2421"}, {"subsystem": "Transport Outer Membrane", "name": "Uridine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["URItex"]}, "metabolites": {"uri_p": 1.0, "uri_e": -1.0}, "id": "URItex", "gene_reaction_rule": "STM0413"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "UDP-sugar hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["USHD"]}, "metabolites": {"u23ga_c": -1.0, "h2o_c": -1.0, "h_c": 2.0, "lipidX_c": 1.0, "ump_c": 1.0}, "id": "USHD", "gene_reaction_rule": "STM0535"}, {"subsystem": "Valine Leucine and Isoleucine Metabolism", "name": "Valine transaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["VALTA"]}, "metabolites": {"akg_c": -1.0, "glu__L_c": 1.0, "val__L_c": -1.0, "3mob_c": 1.0}, "id": "VALTA", "gene_reaction_rule": "STM3903"}, {"subsystem": "tRNA charging", "name": "Valyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["VALTRS"]}, "metabolites": {"valtrna_c": 1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "trnaval_c": -1.0, "val__L_c": -1.0}, "id": "VALTRS", "gene_reaction_rule": "STM4475"}, {"subsystem": "Transport Inner Membrane", "name": "L-valine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["VALabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "val__L_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "val__L_c": 1.0}, "id": "VALabcpp", "gene_reaction_rule": "STM3560 and STM3561 and STM3563 and STM3567 and STM3562"}, {"subsystem": "Transport Inner Membrane", "name": "L-valine reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["VALt2rpp"]}, "metabolites": {"val__L_p": -1.0, "h_c": 1.0, "h_p": -1.0, "val__L_c": 1.0}, "id": "VALt2rpp", "gene_reaction_rule": "STM0399"}, {"subsystem": "Transport Outer Membrane Porin", "name": "L-valine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["VALtex"]}, "metabolites": {"val__L_e": -1.0, "val__L_p": 1.0}, "id": "VALtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "Valine-pyruvate aminotransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["VPAMT"]}, "metabolites": {"pyr_c": 1.0, "3mob_c": -1.0, "ala__L_c": -1.0, "val__L_c": 1.0}, "id": "VPAMTr", "gene_reaction_rule": "STM3665"}, {"subsystem": "Alternate Carbon Metabolism", "name": "L-xylulose 5-phosphate 3-epimerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["X5PL3E"]}, "metabolites": {"xu5p__L_c": -1.0, "ru5p__L_c": 1.0}, "id": "X5PL3E", "gene_reaction_rule": "STM4387"}, {"subsystem": "Transport Inner Membrane", "name": "Xanthine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["XANt2pp"]}, "metabolites": {"h_p": -1.0, "xan_p": -1.0, "xan_c": 1.0, "h_c": 1.0}, "id": "XANt2pp", "gene_reaction_rule": "STM3747"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Xanthine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XANtex"]}, "metabolites": {"xan_e": -1.0, "xan_p": 1.0}, "id": "XANtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "Xanthine reversible transport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XANtpp"]}, "metabolites": {"xan_p": -1.0, "xan_c": 1.0}, "id": "XANtpp", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "XMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XMPtex"]}, "metabolites": {"xmp_p": 1.0, "xmp_e": -1.0}, "id": "XMPtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Xanthine phosphoribosyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["XPPT"]}, "metabolites": {"xmp_c": 1.0, "ppi_c": 1.0, "prpp_c": -1.0, "xan_c": -1.0}, "id": "XPPT", "gene_reaction_rule": "STM0317"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Xanthosine hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["XTSNH"]}, "metabolites": {"h2o_c": -1.0, "rib__D_c": 1.0, "xan_c": 1.0, "xtsn_c": -1.0}, "id": "XTSNH", "gene_reaction_rule": "STM0051"}, {"subsystem": "Transport Inner Membrane", "name": "Xanthosine transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XTSNt2rpp"]}, "metabolites": {"xtsn_p": -1.0, "h_c": 1.0, "h_p": -1.0, "xtsn_c": 1.0}, "id": "XTSNt2rpp", "gene_reaction_rule": "STM2421"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Xanthosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XTSNtex"]}, "metabolites": {"xtsn_e": -1.0, "xtsn_p": 1.0}, "id": "XTSNtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Xylose isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XYLI1"]}, "metabolites": {"xylu__D_c": 1.0, "xyl__D_c": -1.0}, "id": "XYLI1", "gene_reaction_rule": "STM3661"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Xylose isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XYLI2"]}, "metabolites": {"glc__D_c": -1.0, "fru_c": 1.0}, "id": "XYLI2", "gene_reaction_rule": "STM3661"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Xylulokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["XYLK"]}, "metabolites": {"xylu__D_c": -1.0, "xu5p__D_c": 1.0, "atp_c": -1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "XYLK", "gene_reaction_rule": "STM3660 or STM0103"}, {"subsystem": "Alternate Carbon Metabolism", "name": "L-xylulokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["XYLK2"]}, "metabolites": {"xylu__L_c": -1.0, "xu5p__L_c": 1.0, "atp_c": -1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "XYLK2", "gene_reaction_rule": "STM0103 or STM3674"}, {"subsystem": "Transport Inner Membrane", "name": "L-xylulose transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["XYLUt2pp"]}, "metabolites": {"xylu__L_c": 1.0, "xylu__L_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "XYLUt2pp", "gene_reaction_rule": "STM3671 and STM3672 and STM3673"}, {"subsystem": "Transport Outer Membrane Porin", "name": "L-xylulose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XYLUtex"]}, "metabolites": {"xylu__L_p": 1.0, "xylu__L_e": -1.0}, "id": "XYLUtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "D-xylose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XYLtex"]}, "metabolites": {"xyl__D_e": -1.0, "xyl__D_p": 1.0}, "id": "XYLtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "D-xylose transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["XYLt2pp"]}, "metabolites": {"h_p": -1.0, "xyl__D_c": 1.0, "xyl__D_p": -1.0, "h_c": 1.0}, "id": "XYLt2pp", "gene_reaction_rule": "STM0042"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Zinc (Zn+2) ABC transporter, efflux (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ZN2abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "zn2_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "zn2_c": -1.0}, "id": "ZN2abcpp", "gene_reaction_rule": "STM3576"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Zinc (Zn+2) transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ZN2t3pp"]}, "metabolites": {"h_p": -1.0, "zn2_c": -1.0, "zn2_p": 1.0, "h_c": 1.0}, "id": "ZN2t3pp", "gene_reaction_rule": "STM0758 or STM4061"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Zinc transport in via permease (no H+)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ZN2tpp"]}, "metabolites": {"zn2_c": 1.0, "zn2_p": -1.0}, "id": "ZN2tpp", "gene_reaction_rule": "STM3190"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Zinc (Zn+2) transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ZNabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "zn2_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "zn2_c": 1.0}, "id": "ZNabcpp", "gene_reaction_rule": "STM1891 and STM1893 and STM1892_S"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Zinc (Zn+2) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["Zn2tex"]}, "metabolites": {"zn2_e": -1.0, "zn2_p": 1.0}, "id": "Zn2tex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Folate Metabolism", "name": "Glycolaldehyde dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GCALDD"]}, "metabolites": {"h2o_c": -1.0, "glyclt_c": 1.0, "h_c": 2.0, "nad_c": -1.0, "nadh_c": 1.0, "gcald_c": -1.0}, "id": "GCALDD", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Thiazole phosphate synthesis", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THZPSN"]}, "metabolites": {"cys__L_c": -1.0, "h2o_c": 1.0, "atp_c": -1.0, "4mpetz_c": 1.0, "ppi_c": 1.0, "ala__L_c": 1.0, "4hba_c": 1.0, "dxyl5p_c": -1.0, "h_c": 1.0, "tyr__L_c": -1.0, "co2_c": 1.0, "amp_c": 1.0}, "id": "THZPSN", "gene_reaction_rule": "STM2543 and STM4162 and (STM4159 and STM4160) and STM0425 and STM4161"}, {"subsystem": "Exchange", "name": "AEP exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_AEP_e"]}, "metabolites": {"AEP_e": -1.0}, "id": "EX_AEP_e", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "AEP transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AEPtex"]}, "metabolites": {"AEP_e": -1.0, "AEP_p": 1.0}, "id": "AEPtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "AEP transport via ABC system periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AEPabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "AEP_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "AEP_p": -1.0}, "id": "AEPabcpp", "gene_reaction_rule": "STM0426 and STM0427 and STM0429 and STM0428"}, {"subsystem": "aminophosphonate metabolism", "name": "2 aminoethylphosphonate pyruvate transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AEPPYRTA"]}, "metabolites": {"Pald_c": 1.0, "pyr_c": -1.0, "ala__L_c": 1.0, "AEP_c": -1.0}, "id": "AEPPYRTA", "gene_reaction_rule": "STM0431"}, {"subsystem": "aminophosphonate metabolism", "name": "Phosphonoacetaldehyde hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PALDH"]}, "metabolites": {"acald_c": 1.0, "Pald_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0}, "id": "PALDH", "gene_reaction_rule": "STM0432"}, {"subsystem": "Exchange", "name": "4 hydroxy phenylacetic acid exhcnage", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_4hoxpac_e"]}, "metabolites": {"4hoxpac_e": -1.0}, "id": "EX_4hoxpac_e", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "4 hydroxyphenylacetate transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["4hoxpactex"]}, "metabolites": {"4hoxpac_p": 1.0, "4hoxpac_e": -1.0}, "id": "4hoxpactex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "4 hydroxyphenylacetate transport in via proton symport periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["4HOXPACt2pp"]}, "metabolites": {"4hoxpac_c": 1.0, "4hoxpac_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "4HOXPACt2pp_1", "gene_reaction_rule": "STM1107"}, {"subsystem": "4 hydroxyphenylacetate catabolism", "name": "FAD reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FADRx", "FLAVNADR"]}, "metabolites": {"fadh2_c": 1.0, "nadh_c": -1.0, "fad_c": -1.0, "nad_c": 1.0, "h_c": -1.0}, "id": "FADRx_copy2", "gene_reaction_rule": "STM1098"}, {"subsystem": "4 hydroxyphenylacetate catabolism", "name": "4 hydroxyphenylacetate 3 monooxygenase nadh", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["4HOXPACMON"]}, "metabolites": {"o2_c": -1.0, "h2o_c": 1.0, "34dhpacet_c": 1.0, "4hoxpac_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "nadh_c": -1.0}, "id": "4HOXPACMON", "gene_reaction_rule": "STM1098 or STM1099"}, {"subsystem": "4 hydroxyphenylacetate catabolism", "name": "4 hydroxyphenylacetate 3 monooxygenase FADH2", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["4HOXPACMOF"]}, "metabolites": {"o2_c": -1.0, "h2o_c": 1.0, "34dhpacet_c": 1.0, "4hoxpac_c": -1.0, "fadh2_c": -1.0, "fad_c": 1.0}, "id": "4HOXPACMOF_1", "gene_reaction_rule": "STM1099"}, {"subsystem": "4 hydroxyphenylacetate catabolism", "name": "3 4 dihydroxyphenylacetate 2 3 dioxygenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["34DHPACDO"]}, "metabolites": {"2h5cmmusa_c": 1.0, "o2_c": -1.0, "34dhpacet_c": -1.0, "h_c": 1.0}, "id": "34DHPACDO", "gene_reaction_rule": "STM1103"}, {"subsystem": "4 hydroxyphenylacetate catabolism", "name": "4 carboxy 2 hydroxymuconate 6 semialdehyde dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["4C2HM6SADH"]}, "metabolites": {"2h5cmmusa_c": -1.0, "h2o_c": -1.0, "nad_c": -1.0, "h_c": 2.0, "5cm2hmu_c": 1.0, "nadh_c": 1.0}, "id": "4C2HM6SADH", "gene_reaction_rule": "STM1102"}, {"subsystem": "4 hydroxyphenylacetate catabolism", "name": "5 carboxymethyl 2 hydroxymuconate delta isomerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["5CM2HMUDI"]}, "metabolites": {"5c2o3ed_c": 1.0, "5cm2hmu_c": -1.0}, "id": "5CM2HMUDI", "gene_reaction_rule": "STM1104"}, {"subsystem": "4 hydroxyphenylacetate catabolism", "name": "5 carboxy 2 oxohept 3 enedioate decarboxylation", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["5C2O3EDDC"]}, "metabolites": {"co2_c": 1.0, "5c2o3ed_c": -1.0, "h_c": -1.0, "2hh24dd_c": 1.0}, "id": "5C2O3EDDC", "gene_reaction_rule": "STM1101"}, {"subsystem": "4 hydroxyphenylacetate catabolism", "name": "2hh24dd hydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2HH24DDH"]}, "metabolites": {"h2o_c": -1.0, "4h2kpi_c": 1.0, "2hh24dd_c": -1.0}, "id": "2HH24DDH", "gene_reaction_rule": "STM1105"}, {"subsystem": "4 hydroxyphenylacetate catabolism", "name": "4h2kpi Lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["4H2KPILY"]}, "metabolites": {"pyr_c": 1.0, "sucsal_c": 1.0, "4h2kpi_c": -1.0}, "id": "4H2KPILY", "gene_reaction_rule": "STM1106"}, {"subsystem": "1 2 Propanediol Catabolism", "name": " R Propane 1 2 diol dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["12PPDRDH"]}, "metabolites": {"h2o_c": 1.0, "ppal_c": 1.0, "12ppd__R_c": -1.0}, "id": "12PPDRDH", "gene_reaction_rule": "STM2040 and STM2041 and STM2042 and STM2043 and STM2044"}, {"subsystem": "1 2 Propanediol Catabolism", "name": "Propanediol dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["12PPDSDH"]}, "metabolites": {"h2o_c": 1.0, "ppal_c": 1.0, "12ppd__S_c": -1.0}, "id": "PPDD", "gene_reaction_rule": "STM2040 and STM2041 and STM2042 and STM2043 and STM2044"}, {"subsystem": "1 2 Propanediol Catabolism", "name": "Alcohol dehydrogenase Propanal ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALCDPPAL"]}, "metabolites": {"nad_c": 1.0, "ppal_c": -1.0, "ppoh_c": 1.0, "nadh_c": -1.0, "h_c": -1.0}, "id": "ALCD3ir", "gene_reaction_rule": "STM2052"}, {"subsystem": "1 2 Propanediol Catabolism", "name": "Methylmalonate-semialdehyde dehydrogenase (propanol)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["COAPPALDH"]}, "metabolites": {"nad_c": -1.0, "ppal_c": -1.0, "coa_c": -1.0, "h_c": 1.0, "ppcoa_c": 1.0, "nadh_c": 1.0}, "id": "MMSAD2", "gene_reaction_rule": "STM2051"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Sirohydrochlorin cobaltochelatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DSCLCOCH"]}, "metabolites": {"dscl_c": -1.0, "h_c": 2.0, "cobalt2_c": -1.0, "codscl2_c": 1.0}, "id": "DSCLCOCH", "gene_reaction_rule": "STM2025 or STM3477"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Cobalt II transport via ABC system periplasm I", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["Cobalt2abcppI"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "cobalt2_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "cobalt2_p": -1.0}, "id": "Cobalt2abcppI", "gene_reaction_rule": "STM2023 and STM2022 and STM2021 and STM2020"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Cobalt transport in via permease (no H+)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["COBALT2tpp", "Cobalt2abcppII"]}, "metabolites": {"cobalt2_p": -1.0, "cobalt2_c": 1.0}, "id": "COBALT2tpp_copy2", "gene_reaction_rule": "STM2023 and STM2022"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Cobalt precorrin 2 methyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CODSCL2MT"]}, "metabolites": {"amet_c": -1.0, "ahcys_c": 1.0, "codscl3_c": 1.0, "codscl2_c": -1.0, "h_c": 1.0}, "id": "CODSCL2MT", "gene_reaction_rule": "STM2024"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Cobalt precorrin 3 C17 methyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CODSCL3MT"]}, "metabolites": {"amet_c": -1.0, "ahcys_c": 1.0, "codscl3_c": -1.0, "codscl4_c": 1.0}, "id": "CODSCL3MT", "gene_reaction_rule": "STM2027"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Cobalt precorrin 4 methyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CODSCL4MT"]}, "metabolites": {"amet_c": -1.0, "codscl5a_c": 1.0, "ahcys_c": 1.0, "h_c": 1.0, "codscl4_c": -1.0}, "id": "CODSCL4MT", "gene_reaction_rule": "STM2029"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Cobalt precorrin 5a deacetylation", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CODSCL5DA"]}, "metabolites": {"acald_c": 1.0, "codscl5a_c": -1.0, "h2o_c": -1.0, "codscl5b_c": 1.0, "h_c": 1.0}, "id": "CODSCL5DA", "gene_reaction_rule": "STM2028"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Cobalt precorrin 5b methyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CODSCL5BMT"]}, "metabolites": {"codscl6a_c": 1.0, "amet_c": -1.0, "ahcys_c": 1.0, "h_c": 1.0, "codscl5b_c": -1.0}, "id": "CODSCL5BMT", "gene_reaction_rule": "STM2032"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Cobalt precorrin 6a reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CODSCL6ARED"]}, "metabolites": {"codscl6b_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "codscl6a_c": -1.0}, "id": "CODSCL6ARED", "gene_reaction_rule": "STM2026"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Cobalt precorrin 6b methyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CODSCL6BMT"]}, "metabolites": {"codscl7_c": 1.0, "codscl6b_c": -1.0, "ahcys_c": 1.0, "h_c": 1.0, "amet_c": -1.0}, "id": "CODSCL6BMT", "gene_reaction_rule": "STM2031"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Cobalt precorrin 7 methyltransferase decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CODSCL7MTDC"]}, "metabolites": {"codscl8x_c": 1.0, "ahcys_c": 1.0, "codscl7_c": -1.0, "co2_c": 1.0, "amet_c": -1.0}, "id": "CODSCL7MTDC", "gene_reaction_rule": "STM2030"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Cobalt precorrin 8x isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CODSCL8XI"]}, "metabolites": {"codscl8x_c": -1.0, "cobn_c": 1.0}, "id": "CODSCL8XI", "gene_reaction_rule": "STM2033"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Cobyrinate amidation", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["COBNAD"]}, "metabolites": {"h2o_c": -2.0, "atp_c": -2.0, "cob2nda_c": 1.0, "h_c": 2.0, "adp_c": 2.0, "cobn_c": -1.0, "pi_c": 2.0, "glu__L_c": 2.0, "gln__L_c": -2.0}, "id": "COBNAD", "gene_reaction_rule": "STM2035"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Cob II yrinate a c diamide reductase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["COB2NDARED"]}, "metabolites": {"fmnh2_c": -1.0, "cob2nda_c": -2.0, "fmn_c": 1.0, "h_c": 2.0, "cob1nda_c": 2.0}, "id": "COB2NDARED", "gene_reaction_rule": "s0001"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Cob I yrinate a c diamide adenosyltransferase 1", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["COB1NDAAT1"]}, "metabolites": {"pppi_c": 1.0, "adcob1nda_c": 1.0, "h_c": -1.0, "atp_c": -1.0, "cob1nda_c": -1.0}, "id": "COB1NDAAT1", "gene_reaction_rule": "STM2050 or STM1718"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Cob I yrinate a c diamide adenosyltransferase 2", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["COB1NDAAT2"]}, "metabolites": {"h2o_c": -1.0, "adcob1nda_c": 1.0, "atp_c": -1.0, "ppi_c": 1.0, "pi_c": 1.0, "cob1nda_c": -1.0}, "id": "COB1NDAAT2", "gene_reaction_rule": "STM2467"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Adenosylcobyric acid synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADCOBNSYN"]}, "metabolites": {"h2o_c": -4.0, "adcob1nda_c": -1.0, "atp_c": -4.0, "glu__L_c": 4.0, "h_c": 4.0, "adp_c": 4.0, "gln__L_c": -4.0, "pi_c": 4.0, "adcobn_c": 1.0}, "id": "ADCOBNSYN", "gene_reaction_rule": "STM2019"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "L threonine kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LTHRK"]}, "metabolites": {"thrp_c": 1.0, "thr__L_c": -1.0, "atp_c": -1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "LTHRK", "gene_reaction_rule": "STM2058"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "L threonine phosphate decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THRPDC"]}, "metabolites": {"co2_c": 1.0, "h_c": -1.0, "thrp_c": -1.0, "appp_c": 1.0}, "id": "THRPDC", "gene_reaction_rule": "STM0644"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Adenosyl cobinamide phosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADOCBIPS"]}, "metabolites": {"adocbip_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "appp_c": -1.0, "adcobn_c": -1.0}, "id": "ADOCBIPS", "gene_reaction_rule": "STM2034"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Adenosylcobalamin phosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADOCBLPS"]}, "metabolites": {"5prdmbz_c": -1.0, "gmp_c": 1.0, "h_c": 1.0, "adocblp_c": 1.0, "agdpcbi_c": -1.0}, "id": "ADOCBLPS", "gene_reaction_rule": "STM2017"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Adenosylcobalamin phosphate phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADOCBLPP"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "adocblp_c": -1.0, "adocbl_c": 1.0}, "id": "ADOCBLPP", "gene_reaction_rule": "STM0643"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Adenosyl cobinamide kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADOCBIK"]}, "metabolites": {"adocbip_c": 1.0, "adocbi_c": -1.0, "atp_c": -1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "ADOCBIK", "gene_reaction_rule": "STM2018 or STM1208"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Cob(I)alamin adenosyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CBLAT"]}, "metabolites": {"adocbl_c": 1.0, "cbl1_c": -1.0, "h_c": -1.0, "atp_c": -1.0, "pppi_c": 1.0}, "id": "CBLAT", "gene_reaction_rule": "STM1718 or STM2050 or STM2467"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "1 amino 2 propanol kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["APPK"]}, "metabolites": {"app_c": -1.0, "adp_c": 1.0, "atp_c": -1.0, "appp_c": 1.0}, "id": "APPK", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "Residual atoms of reaction DMBZIDSYN exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_remnant1_e"]}, "metabolites": {"remnant1_e": -1.0}, "id": "EX_remnant1_e", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "Residual atoms of reaction DMBZIDSYN transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["REMNANT1tex"]}, "metabolites": {"remnant1_e": -1.0, "remnant1_p": 1.0}, "id": "REMNANT1tex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Exchange", "name": "O antigen x20 core oligosaccharide lipid A exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_colipa20Oag_e"]}, "metabolites": {"colipa20Oag_e": -1.0}, "id": "EX_colipa20Oag_e", "gene_reaction_rule": ""}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "O antigen x20 core oligosaccharide lipid A transport periplasm to extracellular ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["colipa20Oagtex"]}, "metabolites": {"colipa20Oag_p": -1.0, "colipa20Oag_e": 1.0}, "id": "colipa20Oagtex", "gene_reaction_rule": ""}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "O antigen x20 ligase periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["udcdp20OagLpp"]}, "metabolites": {"colipa_p": -1.0, "colipa20Oag_p": 1.0, "udcpdp_p": 1.0, "h_p": 1.0, "udcdp20Oag_p": -1.0}, "id": "udcdp20OagLpp", "gene_reaction_rule": "STM3713"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Undecaprenyl diphosphate galactose rhamnose mannose abequose flippase cytoplasm to periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["udcdpgalrmnmanabetpp"]}, "metabolites": {"udcdpgalrmnmanabe_p": 1.0, "udcdpgalrmnmanabe_c": -1.0}, "id": "udcdpgalrmnmanabetpp", "gene_reaction_rule": "STM2088"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Galactosyltransferase LPS O antigen biosynthesis ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OGLT"]}, "metabolites": {"ump_c": 1.0, "udcpp_c": -1.0, "udcdpgal_c": 1.0, "udpgal_c": -1.0}, "id": "OGLT", "gene_reaction_rule": "STM2082"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Rhamnosyl transferase LPS O antigen biosynthesis ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ORLT"]}, "metabolites": {"dtdprmn_c": -1.0, "udcdpgalrmn_c": 1.0, "dtdp_c": 1.0, "h_c": 1.0, "udcdpgal_c": -1.0}, "id": "ORLT", "gene_reaction_rule": "STM2085"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Mannosyl transferase LPS O antigen biosynthesis ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OMLT"]}, "metabolites": {"udcdpgalrmnman_c": 1.0, "udcdpgalrmn_c": -1.0, "gdp_c": 1.0, "h_c": 1.0, "gdpmann_c": -1.0}, "id": "OMLT", "gene_reaction_rule": "STM2086"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Abequosyl transferase LPS O antigen biosynthesis ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OALT"]}, "metabolites": {"cdp_c": 1.0, "cdpabeq_c": -1.0, "h_c": 1.0, "udcdpgalrmnmanabe_c": 1.0, "udcdpgalrmnman_c": -1.0}, "id": "OALT", "gene_reaction_rule": "STM2087"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Mannose-1-phosphate guanylyltransferase (GDP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MAN1PT2"]}, "metabolites": {"man1p_c": -1.0, "pi_c": 1.0, "gdp_c": -1.0, "gdpmann_c": 1.0, "h_c": -1.0}, "id": "MAN1PT2", "gene_reaction_rule": "STM2105_S or STM2084"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Phosphomannomutase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PMANM"]}, "metabolites": {"man1p_c": -1.0, "man6p_c": 1.0}, "id": "PMANM", "gene_reaction_rule": "STM2104 or STM2083"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "O antigen polymerase 1 periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OAP1pp"]}, "metabolites": {"udcdp2Oag_p": 1.0, "udcpdp_p": 1.0, "udcdpgalrmnmanabe_p": -2.0, "h_p": 1.0}, "id": "OAP1pp", "gene_reaction_rule": "STM1332"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "O antigen polymerase 2 periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OAP2pp"]}, "metabolites": {"h_p": 1.0, "udcdp2Oag_p": -1.0, "udcpdp_p": 1.0, "udcdpgalrmnmanabe_p": -1.0, "udcdp3Oag_p": 1.0}, "id": "OAP2pp", "gene_reaction_rule": "STM1332"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "O antigen polymerase 3 periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OAP3pp"]}, "metabolites": {"h_p": 1.0, "udcdp4Oag_p": 1.0, "udcpdp_p": 1.0, "udcdpgalrmnmanabe_p": -1.0, "udcdp3Oag_p": -1.0}, "id": "OAP3pp", "gene_reaction_rule": "STM1332"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "O antigen polymerase 4 periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OAP4pp"]}, "metabolites": {"udcdp5Oag_p": 1.0, "udcpdp_p": 1.0, "udcdpgalrmnmanabe_p": -1.0, "h_p": 1.0, "udcdp4Oag_p": -1.0}, "id": "OAP4pp", "gene_reaction_rule": "STM1332"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "O antigen polymerase 5 periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OAP5pp"]}, "metabolites": {"udcdp5Oag_p": -1.0, "udcpdp_p": 1.0, "udcdp6Oag_p": 1.0, "h_p": 1.0, "udcdpgalrmnmanabe_p": -1.0}, "id": "OAP5pp", "gene_reaction_rule": "STM1332"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "O antigen polymerase 6 periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OAP6pp"]}, "metabolites": {"udcdp7Oag_p": 1.0, "udcpdp_p": 1.0, "udcdp6Oag_p": -1.0, "h_p": 1.0, "udcdpgalrmnmanabe_p": -1.0}, "id": "OAP6pp", "gene_reaction_rule": "STM1332"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "O antigen polymerase 7 periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OAP7pp"]}, "metabolites": {"udcdp7Oag_p": -1.0, "udcpdp_p": 1.0, "udcdpgalrmnmanabe_p": -1.0, "h_p": 1.0, "udcdp8Oag_p": 1.0}, "id": "OAP7pp", "gene_reaction_rule": "STM1332"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "O antigen polymerase 8 periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OAP8pp"]}, "metabolites": {"udcpdp_p": 1.0, "udcdp9Oag_p": 1.0, "udcdpgalrmnmanabe_p": -1.0, "h_p": 1.0, "udcdp8Oag_p": -1.0}, "id": "OAP8pp", "gene_reaction_rule": "STM1332"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "O antigen polymerase 9 periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OAP9pp"]}, "metabolites": {"udcdp10Oag_p": 1.0, "udcpdp_p": 1.0, "udcdp9Oag_p": -1.0, "udcdpgalrmnmanabe_p": -1.0, "h_p": 1.0}, "id": "OAP9pp", "gene_reaction_rule": "STM1332"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "O antigen polymerase 10 periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OAP10pp"]}, "metabolites": {"udcdp10Oag_p": -1.0, "udcpdp_p": 1.0, "udcdp11Oag_p": 1.0, "udcdpgalrmnmanabe_p": -1.0, "h_p": 1.0}, "id": "OAP10pp", "gene_reaction_rule": "STM1332"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "O antigen polymerase 11 periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OAP11pp"]}, "metabolites": {"h_p": 1.0, "udcdp12Oag_p": 1.0, "udcpdp_p": 1.0, "udcdpgalrmnmanabe_p": -1.0, "udcdp11Oag_p": -1.0}, "id": "OAP11pp", "gene_reaction_rule": "STM1332"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "O antigen polymerase 12 periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OAP12pp"]}, "metabolites": {"udcdp13Oag_p": 1.0, "udcdp12Oag_p": -1.0, "udcpdp_p": 1.0, "udcdpgalrmnmanabe_p": -1.0, "h_p": 1.0}, "id": "OAP12pp", "gene_reaction_rule": "STM1332"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "O antigen polymerase 13 periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OAP13pp"]}, "metabolites": {"udcdp13Oag_p": -1.0, "udcpdp_p": 1.0, "udcdp14Oag_p": 1.0, "h_p": 1.0, "udcdpgalrmnmanabe_p": -1.0}, "id": "OAP13pp", "gene_reaction_rule": "STM1332"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "O antigen polymerase 14 periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OAP14pp"]}, "metabolites": {"udcdp15Oag_p": 1.0, "udcpdp_p": 1.0, "udcdp14Oag_p": -1.0, "h_p": 1.0, "udcdpgalrmnmanabe_p": -1.0}, "id": "OAP14pp", "gene_reaction_rule": "STM1332"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "O antigen polymerase 15 periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OAP15pp"]}, "metabolites": {"udcdp15Oag_p": -1.0, "udcpdp_p": 1.0, "udcdpgalrmnmanabe_p": -1.0, "h_p": 1.0, "udcdp16Oag_p": 1.0}, "id": "OAP15pp", "gene_reaction_rule": "STM1332"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "O antigen polymerase 16 periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OAP16pp"]}, "metabolites": {"udcpdp_p": 1.0, "udcdp17Oag_p": 1.0, "udcdpgalrmnmanabe_p": -1.0, "h_p": 1.0, "udcdp16Oag_p": -1.0}, "id": "OAP16pp", "gene_reaction_rule": "STM1332"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "O antigen polymerase 17 periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OAP17pp"]}, "metabolites": {"udcdp18Oag_p": 1.0, "udcpdp_p": 1.0, "udcdp17Oag_p": -1.0, "udcdpgalrmnmanabe_p": -1.0, "h_p": 1.0}, "id": "OAP17pp", "gene_reaction_rule": "STM1332"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "O antigen polymerase 18 periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OAP18pp"]}, "metabolites": {"h_p": 1.0, "udcdp18Oag_p": -1.0, "udcpdp_p": 1.0, "udcdpgalrmnmanabe_p": -1.0, "udcdp19Oag_p": 1.0}, "id": "OAP18pp", "gene_reaction_rule": "STM1332"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "O antigen polymerase 19 periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OAP19pp"]}, "metabolites": {"h_p": 1.0, "udcpdp_p": 1.0, "udcdpgalrmnmanabe_p": -1.0, "udcdp19Oag_p": -1.0, "udcdp20Oag_p": 1.0}, "id": "OAP19pp", "gene_reaction_rule": "STM1332"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Alpha-D-glucose cytidylyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G1PCT"]}, "metabolites": {"ctp_c": -1.0, "ppi_c": 1.0, "cdpglc_c": 1.0, "h_c": -1.0, "g1p_c": -1.0}, "id": "G1PCTYT", "gene_reaction_rule": "STM2092"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "CDP glucose 4 6 dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDPGLC46DH"]}, "metabolites": {"h2o_c": 1.0, "cdpglc_c": -1.0, "cdp4dh6doglc_c": 1.0}, "id": "CDPGLC46DH", "gene_reaction_rule": "STM2091"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "CDP 4 dehydro 6 deoxyglucose reductase ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDP4D6DGLCRx"]}, "metabolites": {"h2o_c": 1.0, "cdp4dh36ddglc_c": 1.0, "h_c": -1.0, "nad_c": 1.0, "cdp4dh6doglc_c": -1.0, "nadh_c": -1.0}, "id": "CDP4D6DGLCRx", "gene_reaction_rule": "STM2090 and STM2093"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "CDP abequose synthase ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDPABEQS"]}, "metabolites": {"cdpabeq_c": 1.0, "nadh_c": -1.0, "cdp4dh36ddglc_c": -1.0, "nad_c": 1.0, "h_c": -1.0}, "id": "CDPABEQS", "gene_reaction_rule": "STM2089"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Salmochelin S4 Fe III binding spontaneous ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SALCHS4FEexs"]}, "metabolites": {"salchs4fe_e": 1.0, "salchs4_e": -1.0, "fe3_e": -1.0}, "id": "SALCHS4FEexs", "gene_reaction_rule": "s0001"}, {"subsystem": "Extracellular exchange", "name": "Salmochelin S4 exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_SALCHS4_e"]}, "metabolites": {"salchs4_e": -1.0}, "id": "EX_salchs4_e", "gene_reaction_rule": ""}, {"subsystem": "Extracellular exchange", "name": "Salmochelin S4 Fe III exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_SALCHS4FE_e"]}, "metabolites": {"salchs4fe_e": -1.0}, "id": "EX_salchs4fe_e", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Salmochelin S4 Fe III transport via ABC system periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SALCHS4FEabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "salchs4fe_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "salchs4fe_p": -1.0}, "id": "SALCHS4FEabcpp", "gene_reaction_rule": "STM0594 and STM0590 and STM0592 and STM0591"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Salmochelin S4 transport secretion periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SALCHS4tex"]}, "metabolites": {"salchs4_e": 1.0, "salchs4_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "SALCHS4tex", "gene_reaction_rule": ""}, {"subsystem": "Transport Inner Membrane", "name": "Salmochelin S4 transport via ABC system periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SALCHS4abcpp"]}, "metabolites": {"h2o_c": -1.0, "salchs4_p": 1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "salchs4_c": -1.0, "pi_c": 1.0}, "id": "SALCHS4abcpp", "gene_reaction_rule": "STM2774"}, {"subsystem": "Transport Inner Membrane", "name": "Enterochelin transport2 via ABC system periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FEENTER2tpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "enter_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "enter_c": -1.0}, "id": "FEENTER2tpp", "gene_reaction_rule": "STM2774"}, {"subsystem": "Extracellular exchange", "name": "Salmochelin SX exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_SALCHSX_e"]}, "metabolites": {"salchsx_e": -1.0}, "id": "EX_salchsx_e", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "Salmochelin SX via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SALCHSXtex"]}, "metabolites": {"salchsx_p": 1.0, "salchsx_e": -1.0}, "id": "SALCHSXtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "Salmochelin SX facilitated transport periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SALCHSXtpp"]}, "metabolites": {"salchsx_p": -1.0, "salchsx_c": 1.0}, "id": "SALCHSXtpp", "gene_reaction_rule": ""}, {"subsystem": "Transport Inner Membrane", "name": "Cytosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CSNt2pp"]}, "metabolites": {"csn_p": -1.0, "csn_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "CSNt2pp", "gene_reaction_rule": "STM3333"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Cytosine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CSND"]}, "metabolites": {"ura_c": 1.0, "h2o_c": -1.0, "csn_c": -1.0, "nh4_c": 1.0, "h_c": -1.0}, "id": "CSND", "gene_reaction_rule": "STM3334"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Alcohol dehydrogenase (glycerol)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALCD19"]}, "metabolites": {"h_c": -1.0, "nadh_c": -1.0, "glyald_c": -1.0, "nad_c": 1.0, "glyc_c": 1.0}, "id": "ALCD19", "gene_reaction_rule": "STM1627"}, {"subsystem": "Pyruvate Metabolism", "name": "Alcohol dehydrogenase (ethanol)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALCD2x"]}, "metabolites": {"acald_c": 1.0, "nad_c": -1.0, "nadh_c": 1.0, "h_c": 1.0, "etoh_c": -1.0}, "id": "ALCD2x", "gene_reaction_rule": "STM1627 or STM1567 or STM1749 or STM2461"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Formaldehyde dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FALDH2"]}, "metabolites": {"h_c": 1.0, "nadh_c": 1.0, "hmgth_c": -1.0, "nad_c": -1.0, "Sfglutth_c": 1.0}, "id": "FALDH2", "gene_reaction_rule": "STM1627"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2-dehydropantoate 2-reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DPR"]}, "metabolites": {"pant__R_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "2dhp_c": -1.0}, "id": "DPR", "gene_reaction_rule": "STM3909 or STM0434 or STM2573"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Core oligosaccharide lipid A:hexadecanoate transferase (n-C16:0) (extracellular membrane)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPAHT2ex"]}, "metabolites": {"hdca_e": -1.0, "h_e": -1.0, "h2o_e": 1.0, "hacolipa_e": 1.0, "colipa_e": -1.0}, "id": "LIPAHT2ex", "gene_reaction_rule": "STM0628"}, {"subsystem": "Lipopolysaccharide Biosynthesis Recycling", "name": "Lipid A:hexadecanoate transferase (n-C16:0) (extracellular membrane)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPAHTex"]}, "metabolites": {"lipa_e": -1.0, "hdca_e": -1.0, "h_e": -1.0, "h2o_e": 1.0, "halipa_e": 1.0}, "id": "LIPAHTex", "gene_reaction_rule": "STM0628"}, {"subsystem": "Oxidative Phosphorylation", "name": "Cytochrome oxidase bd (menaquinol-8: 2 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYTBD2pp"]}, "metabolites": {"o2_c": -0.5, "h2o_c": 1.0, "mqn8_c": 1.0, "h_p": 2.0, "h_c": -2.0, "mql8_c": -1.0}, "id": "CYTBD2pp", "gene_reaction_rule": "STM1792 and STM1793"}, {"subsystem": "Oxidative Phosphorylation", "name": "Cytochrome oxidase bd (ubiquinol-8: 2 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYTBDpp"]}, "metabolites": {"o2_c": -0.5, "h2o_c": 1.0, "h_p": 2.0, "q8h2_c": -1.0, "h_c": -2.0, "q8_c": 1.0}, "id": "CYTBDpp", "gene_reaction_rule": "(STM1792 and STM1793) or (STM0740 and STM0741)"}, {"subsystem": "Tyrosine Tryptophan and Phenylalanine Metabolism", "name": "Acetyl-CoA:anthranilate acetyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACANTHAT"]}, "metabolites": {"anth_c": -1.0, "coa_c": 1.0, "accoa_c": -1.0, "acanth_c": 1.0}, "id": "ACANTHAT", "gene_reaction_rule": "STM1582"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Galactitol-1-phosphate dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLTPD"]}, "metabolites": {"nadh_c": 1.0, "tag6p__D_c": 1.0, "h_c": 1.0, "nad_c": -1.0, "galt1p_c": -1.0}, "id": "GLTPD", "gene_reaction_rule": "STM3261"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Tagatose-bisphosphate aldolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TGBPA"]}, "metabolites": {"dhap_c": 1.0, "g3p_c": 1.0, "tagdp__D_c": -1.0}, "id": "TGBPA", "gene_reaction_rule": "STM3257 and STM3253"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glucuronate isomerase (D-glucuronate)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GUI1"]}, "metabolites": {"glcur_c": -1.0, "fruur_c": 1.0}, "id": "GUI1", "gene_reaction_rule": "STM3137"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glucuronate isomerase (D-galacturonate)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GUI2"]}, "metabolites": {"galur_c": -1.0, "tagur_c": 1.0}, "id": "GUI2", "gene_reaction_rule": "STM3137"}, {"subsystem": "Alternate Carbon Metabolism", "name": "D-mannonate hydrolyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MNNH"]}, "metabolites": {"h2o_c": 1.0, "2ddglcn_c": 1.0, "mana_c": -1.0}, "id": "MNNH", "gene_reaction_rule": "STM3135"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Mannonate oxidoreductase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MANAO"]}, "metabolites": {"h_c": 1.0, "nadh_c": 1.0, "fruur_c": 1.0, "nad_c": -1.0, "mana_c": -1.0}, "id": "MANAO", "gene_reaction_rule": "STM3136"}, {"subsystem": "Pyruvate Metabolism", "name": "Oxaloacetate decarboxylase sodium pump", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OAADCS"]}, "metabolites": {"pyr_c": 1.0, "na1_c": -2.0, "h_c": -1.0, "oaa_c": -1.0, "na1_p": 2.0, "co2_c": 1.0}, "id": "OAADCS", "gene_reaction_rule": "(STM0054 and STM0055 and STM0056) or (STM3351 and STM3352 and STM3353)"}, {"subsystem": "Transport Inner Membrane", "name": "Citrate transport via sodium symport periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CITt4pp"]}, "metabolites": {"na1_p": -2.0, "na1_c": 2.0, "cit_p": -1.0, "cit_c": 1.0}, "id": "CITt4pp", "gene_reaction_rule": "STM0057"}, {"subsystem": "Transport Inner Membrane", "name": "2-dehydro-3-deoxy-D-gluconate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DDGLCNt2rpp"]}, "metabolites": {"2ddglcn_p": -1.0, "2ddglcn_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "DDGLCNt2rpp", "gene_reaction_rule": "STM0161"}, {"subsystem": "Transport Inner Membrane", "name": "CITt kt", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CITt2pp"]}, "metabolites": {"cit_p": -1.0, "h_c": 1.0, "h_p": -1.0, "cit_c": 1.0}, "id": "CITt_kt", "gene_reaction_rule": "STM0689"}, {"subsystem": "Transport Inner Membrane", "name": "Citrate transport periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CITtupp"]}, "metabolites": {"cit_p": -1.0, "cit_c": 1.0}, "id": "CITtupp", "gene_reaction_rule": "STM2786 and STM2787 and STM2788"}, {"subsystem": "Transport Inner Membrane", "name": "Isocitrate transport periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ICITtupp"]}, "metabolites": {"icit_p": -1.0, "icit_c": 1.0}, "id": "ICITtupp", "gene_reaction_rule": "STM2786 and STM2787 and STM2788"}, {"subsystem": "Transport Inner Membrane", "name": "Cisaconitate transport periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACONCtupp"]}, "metabolites": {"acon_C_p": -1.0, "acon_C_c": 1.0}, "id": "ACONCtupp", "gene_reaction_rule": "STM2786 and STM2787 and STM2788"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Nickel transport via ABC system (uptake, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NI2uabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "ni2_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "ni2_p": -1.0}, "id": "NI2uabcpp", "gene_reaction_rule": "STM4456 or (STM1255 and STM1256 and STM1257 and STM1258 and STM1259)"}, {"subsystem": "Transport Inner Membrane", "name": "Galactitol transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALTptspp"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "galt1p_c": 1.0, "galt_p": -1.0}, "id": "GALTptspp", "gene_reaction_rule": "STM3258 and STM3259 and STM3260 and STM2431 and STM2432"}, {"subsystem": "Exchange", "name": "D Tagatose exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_tag_D_e"]}, "metabolites": {"tag__D_e": -1.0}, "id": "EX_tag__D_e", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "D Tagatose transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TAGtex"]}, "metabolites": {"tag__D_p": 1.0, "tag__D_e": -1.0}, "id": "TAGtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "D Tagatose transport via PEPPyr PTS periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TAGptspp"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "tag__D_p": -1.0, "tag1p__D_c": 1.0}, "id": "TAGptspp", "gene_reaction_rule": "STM3255 and STM3256 and STM2432"}, {"subsystem": "Alternate Carbon Metabolism", "name": "D Tagatose 1 phosphate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TAG1PK"]}, "metabolites": {"h_c": 1.0, "tag1p__D_c": -1.0, "tagdp__D_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "TAG1PK", "gene_reaction_rule": "STM1326 or STM3254"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Iron (II) transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FE2abcpp"]}, "metabolites": {"h2o_c": -1.0, "fe2_p": -1.0, "atp_c": -1.0, "fe2_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "FE2abcpp", "gene_reaction_rule": "STM3506 or (STM2861 and STM2862 and STM2863 and STM2864)"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Manganese Mn2 transport via ABC system periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MN2abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "mn2_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "mn2_p": -1.0, "pi_c": 1.0}, "id": "MNabc_1", "gene_reaction_rule": "STM2861 and STM2862 and STM2863 and STM2864"}, {"subsystem": "Oxidative Phosphorylation", "name": "Tetrathionate Dehydrogenase menaquinone 8  periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TETDHpp1"]}, "metabolites": {"tet_p": -1.0, "mqn8_c": 1.0, "h_p": 2.0, "mql8_c": -1.0, "tsul_p": 2.0}, "id": "TETDHpp1", "gene_reaction_rule": "STM1383 and STM1385 and STM1384"}, {"subsystem": "Oxidative Phosphorylation", "name": "Thiosulfate Dehydrogenase menaquinone 8  periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TSULDHpp1"]}, "metabolites": {"mqn8_c": 1.0, "h_p": -2.0, "tsul_p": -1.0, "so3_p": 1.0, "h_c": 2.0, "h2s_p": 1.0, "mql8_c": -1.0}, "id": "TSULDHpp1", "gene_reaction_rule": "STM2065 and STM2064 and STM2063"}, {"subsystem": "Oxidative Phosphorylation", "name": "Tetrathionate Dehydrogenase Demethylmenaquinol 8 periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TETDHpp2"]}, "metabolites": {"tet_p": -1.0, "2dmmql8_c": -1.0, "2dmmq8_c": 1.0, "h_p": 2.0, "tsul_p": 2.0}, "id": "TETDHpp2", "gene_reaction_rule": "STM1383 and STM1385 and STM1384"}, {"subsystem": "Oxidative Phosphorylation", "name": "Thiosulfate Dehydrogenase Demethylmenaquinol 8  periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TSULDHpp2"]}, "metabolites": {"2dmmq8_c": 1.0, "h_p": -2.0, "2dmmql8_c": -1.0, "tsul_p": -1.0, "so3_p": 1.0, "h_c": 2.0, "h2s_p": 1.0}, "id": "TSULDHpp2", "gene_reaction_rule": "STM2065 and STM2064 and STM2063"}, {"subsystem": "Oxidative Phosphorylation", "name": "Tetrathionate Dehydrogenase ubiquinone 8  periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TETDHpp3"]}, "metabolites": {"q8h2_c": -1.0, "tet_p": -1.0, "q8_c": 1.0, "h_p": 2.0, "tsul_p": 2.0}, "id": "TETDHpp3", "gene_reaction_rule": "STM1383 and STM1385 and STM1384"}, {"subsystem": "Oxidative Phosphorylation", "name": "Thiosulfate Dehydrogenase ubiquinone 8  periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TSULDHpp3"]}, "metabolites": {"h_p": -2.0, "q8h2_c": -1.0, "tsul_p": -1.0, "so3_p": 1.0, "h_c": 2.0, "q8_c": 1.0, "h2s_p": 1.0}, "id": "TSULDHpp3", "gene_reaction_rule": "STM2065 and STM2064 and STM2063"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Sulfite reductase ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SO3R"]}, "metabolites": {"h2o_c": 3.0, "so3_c": -1.0, "h2s_c": 1.0, "h_c": -5.0, "nad_c": 3.0, "nadh_c": -3.0}, "id": "SO3R", "gene_reaction_rule": "STM2548 and STM2549 and STM2550"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Magnesium (Mg+2) ABC transporter (ubtake, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MG2uabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "mg2_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "mg2_c": 1.0}, "id": "MG2uabcpp", "gene_reaction_rule": "STM4456 or STM3763"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Uroporphyrinogen decarboxylase (uroporphyrinogen III)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UPPDC1"]}, "metabolites": {"co2_c": 4.0, "cpppg3_c": 1.0, "uppg3_c": -1.0, "h_c": -4.0}, "id": "UPPDC1", "gene_reaction_rule": "STM4167"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Aminoimidazole riboside kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AIRSK"]}, "metabolites": {"adp_c": 1.0, "airs_c": -1.0, "h_c": 1.0, "atp_c": -1.0, "air_c": 1.0}, "id": "AIRSK", "gene_reaction_rule": "STM4066"}, {"subsystem": "Exchange", "name": "Aminoimidazole riboside exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_airs_e"]}, "metabolites": {"airs_e": -1.0}, "id": "EX_airs_e", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "Aminoimidazole riboside transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AIRStex"]}, "metabolites": {"airs_p": 1.0, "airs_e": -1.0}, "id": "AIRStex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "Aminoimidazole riboside facilitated transport periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AIRStpp"]}, "metabolites": {"airs_p": -1.0, "airs_c": 1.0}, "id": "AIRStpp", "gene_reaction_rule": ""}, {"subsystem": "Transport Inner Membrane", "name": "Residual atoms of reaction DMBZIDSYN facilitated transport periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["REMNANT1tpp"]}, "metabolites": {"remnant1_p": -1.0, "remnant1_c": 1.0}, "id": "REMNANT1tpp", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Arginine deiminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ARGDA"]}, "metabolites": {"h2o_c": -1.0, "citr__L_c": 1.0, "arg__L_c": -1.0, "nh4_c": 1.0}, "id": "ARGDr", "gene_reaction_rule": "STM4467"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Ornithine carbamoyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["OCBT"]}, "metabolites": {"cbp_c": -1.0, "citr__L_c": 1.0, "orn_c": -1.0, "h_c": 1.0, "pi_c": 1.0}, "id": "OCBT", "gene_reaction_rule": "STM4469 or STM4465"}, {"subsystem": "Unassigned", "name": "Carbamate kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CBMKr"]}, "metabolites": {"cbp_c": 1.0, "atp_c": -1.0, "h_c": 2.0, "adp_c": 1.0, "co2_c": -1.0, "nh4_c": -1.0}, "id": "CBMKr", "gene_reaction_rule": "STM0532 or STM4466"}, {"subsystem": "Transport Inner Membrane", "name": "3 Phospho D glycerate phosphate antiporter periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3PGt6pp"]}, "metabolites": {"pi_p": 1.0, "pi_c": -1.0, "3pg_p": -1.0, "3pg_c": 1.0}, "id": "3PGt6pp", "gene_reaction_rule": "STM2399"}, {"subsystem": "Transport Inner Membrane", "name": "D Glycerate 2 phosphate phosphate antiporter periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2PGt6pp"]}, "metabolites": {"pi_p": 1.0, "pi_c": -1.0, "2pg_p": -1.0, "2pg_c": 1.0}, "id": "2PGt6pp", "gene_reaction_rule": "STM2399"}, {"subsystem": "Transport Inner Membrane", "name": "Phosphoenolpyruvate phosphate antiporter periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PEPt6pp"]}, "metabolites": {"pi_p": 1.0, "pep_c": 1.0, "pep_p": -1.0, "pi_c": -1.0}, "id": "PEPt6pp", "gene_reaction_rule": "STM2399"}, {"subsystem": "Exchange", "name": "Phosphoenolpyruvate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_pep_e"]}, "metabolites": {"pep_e": -1.0}, "id": "EX_pep_e", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "Phosphoenolpyruvate transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PEPtex"]}, "metabolites": {"pep_p": 1.0, "pep_e": -1.0}, "id": "PEPtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Exchange", "name": "D Glycerate 2 phosphate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_2pg_e"]}, "metabolites": {"2pg_e": -1.0}, "id": "EX_2pg_e", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "D Glycerate 2 phosphate transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["2PGtex"]}, "metabolites": {"2pg_e": -1.0, "2pg_p": 1.0}, "id": "2PGtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Exchange", "name": "3 Phospho D glycerate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_3pg_e"]}, "metabolites": {"3pg_e": -1.0}, "id": "EX_3pg_e", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "3 Phospho D glycerate transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["3PGtex"]}, "metabolites": {"3pg_e": -1.0, "3pg_p": 1.0}, "id": "3PGtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Glycine and Serine Metabolism", "name": "L-serine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SERD_L"]}, "metabolites": {"ser__L_c": -1.0, "pyr_c": 1.0, "nh4_c": 1.0}, "id": "SERD_L", "gene_reaction_rule": "STM3240 or STM1826 or STM2971 or STM2196"}, {"subsystem": "Alternate Carbon Metabolism", "name": "L(+)-tartrate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TARTD"]}, "metabolites": {"h2o_c": 1.0, "tartr__L_c": -1.0, "oaa_c": 1.0}, "id": "TARTD", "gene_reaction_rule": "STM3355 and STM3354"}, {"subsystem": "Transport Inner Membrane", "name": "Tartrate facilitated transport periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TARTRtpp"]}, "metabolites": {"tartr__L_p": -1.0, "tartr__L_c": 1.0}, "id": "TARTRtpp", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Nickel (+2) transport in via permease (no H+)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NI2tpp"]}, "metabolites": {"ni2_c": 1.0, "ni2_p": -1.0}, "id": "NI2tpp", "gene_reaction_rule": "STM3952 or STM2783"}, {"subsystem": "Unassigned", "name": "Catalase", "upper_bound": 0.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CAT"]}, "metabolites": {"h2o2_c": -2.0, "h2o_c": 2.0, "o2_c": 1.0}, "id": "CAT", "gene_reaction_rule": "STM1318 or STM4106 or STM1731"}, {"subsystem": "Tyrosine Tryptophan and Phenylalanine Metabolism", "name": "Chorismate mutase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHORM"]}, "metabolites": {"pphn_c": 1.0, "chor_c": -1.0}, "id": "CHORM", "gene_reaction_rule": "STM2667 or STM2669 or STM1269"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2,3-diaminopropionate amonnia lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAPAL"]}, "metabolites": {"h2o_c": -1.0, "pyr_c": 1.0, "nh4_c": 2.0, "23dappa_c": -1.0}, "id": "DAPAL", "gene_reaction_rule": "STM1002"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDPgalactopyranose mutase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UDPGALM"]}, "metabolites": {"udpgal_c": -1.0, "udpgalfur_c": 1.0}, "id": "UDPGALM", "gene_reaction_rule": "STM0719"}, {"subsystem": "Oxidative Phosphorylation", "name": "Hydrogenase (ubiquinone-8: 2 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HYD1pp"]}, "metabolites": {"q8h2_c": 1.0, "h2_c": -1.0, "h_c": -2.0, "h_p": 2.0, "q8_c": -1.0}, "id": "HYD1pp", "gene_reaction_rule": "(STM1786 and STM1787 and STM1788) or (STM3147 and STM3150) or (STM2847 and STM2848 and STM2849 and STM2850 and STM2851 and STM2852) or (STM1538 and STM1539)"}, {"subsystem": "Oxidative Phosphorylation", "name": "Hydrogenase (menaquinone8: 2 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HYD2pp"]}, "metabolites": {"h_p": 2.0, "mqn8_c": -1.0, "h2_c": -1.0, "h_c": -2.0, "mql8_c": 1.0}, "id": "HYD2pp", "gene_reaction_rule": "(STM1786 and STM1787 and STM1788) or (STM3147 and STM3150) or (STM1538 and STM1539)"}, {"subsystem": "Oxidative Phosphorylation", "name": "Hydrogenase (Demethylmenaquinone-8: 2 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HYD3pp"]}, "metabolites": {"h2_c": -1.0, "2dmmql8_c": 1.0, "h_c": -2.0, "h_p": 2.0, "2dmmq8_c": -1.0}, "id": "HYD3pp", "gene_reaction_rule": "(STM1786 and STM1787 and STM1788) or (STM3147 and STM3150) or (STM1538 and STM1539)"}, {"subsystem": "Exchange", "name": "Tetrathionate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_tet_e"]}, "metabolites": {"tet_e": -1.0}, "id": "EX_tet_e", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "Tetrathionate transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TETtex"]}, "metabolites": {"tet_p": 1.0, "tet_e": -1.0}, "id": "TETtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Exchange", "name": "Formamide exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_foam_e"]}, "metabolites": {"foam_e": -1.0}, "id": "EX_foam_e", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "Formamide transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FOAMtex"]}, "metabolites": {"foam_p": 1.0, "foam_e": -1.0}, "id": "FOAMtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Exchange", "name": "D-tartrate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_tartr_D_e"]}, "metabolites": {"tartr__D_e": -1.0}, "id": "EX_tartr__D_e", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "D-tartrate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TARTRDtex"]}, "metabolites": {"tartr__D_p": 1.0, "tartr__D_e": -1.0}, "id": "TARTRDtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "D Tartrate facilitated transport periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TARTRDtpp"]}, "metabolites": {"tartr__D_p": -1.0, "tartr__D_c": 1.0}, "id": "TARTRDtpp", "gene_reaction_rule": "STM3356"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Galactarate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALCTD"]}, "metabolites": {"h2o_c": 1.0, "5dh4dglc_c": 1.0, "galct__D_c": -1.0}, "id": "GALCTD", "gene_reaction_rule": "STM3250 or STM3697"}, {"subsystem": "Methionine Metabolism", "name": "O-succinylhomoserine lyase (L-cysteine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SHSL1"]}, "metabolites": {"cys__L_c": -1.0, "succ_c": 1.0, "suchms_c": -1.0, "h_c": 1.0, "cyst__L_c": 1.0}, "id": "SHSL1", "gene_reaction_rule": "STM4100 or STM3624A"}, {"subsystem": "Transport Inner Membrane", "name": "L-asparate transport via proton symport (3 H) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASPt2_3pp"]}, "metabolites": {"asp__L_c": 1.0, "asp__L_p": -1.0, "h_c": 3.0, "h_p": -3.0}, "id": "ASPt2_3pp", "gene_reaction_rule": "STM4325 or STM4301 or STM3599"}, {"subsystem": "Transport Inner Membrane", "name": "Succinate:fumarate antiporter (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SUCFUMtpp"]}, "metabolites": {"fum_p": -1.0, "succ_p": 1.0, "succ_c": -1.0, "fum_c": 1.0}, "id": "SUCFUMtpp", "gene_reaction_rule": "STM4301 or STM0627 or STM4325 or STM3599"}, {"subsystem": "Transport Inner Membrane", "name": "Succintate transport via proton symport (3 H) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SUCCt2_3pp"]}, "metabolites": {"succ_p": -1.0, "succ_c": 1.0, "h_c": 3.0, "h_p": -3.0}, "id": "SUCCt2_3pp", "gene_reaction_rule": "STM4301 or STM4325 or STM3599"}, {"subsystem": "Transport Inner Membrane", "name": "Fumarate transport via proton symport (3 H) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FUMt2_3pp"]}, "metabolites": {"fum_p": -1.0, "fum_c": 1.0, "h_c": 3.0, "h_p": -3.0}, "id": "FUMt2_3pp", "gene_reaction_rule": "STM4325 or STM4301 or STM0627 or STM3599"}, {"subsystem": "Transport Inner Membrane", "name": "Malate transport via proton symport (3 H) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALt2_3pp"]}, "metabolites": {"mal__L_p": -1.0, "mal__L_c": 1.0, "h_c": 3.0, "h_p": -3.0}, "id": "MALt2_3pp", "gene_reaction_rule": "STM4301 or STM4325 or STM3599"}, {"subsystem": "Murein Recycling", "name": "D alanine D alanine dipeptidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAALAD"]}, "metabolites": {"h2o_p": -1.0, "alaala_p": -1.0, "ala__D_p": 2.0}, "id": "ALAALAD_1", "gene_reaction_rule": "STM1599"}, {"subsystem": "Oxidative Phosphorylation", "name": "Dimethyl sulfoxide reductase (Menaquinol 8) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DMSOR1"]}, "metabolites": {"dmso_p": -1.0, "dms_p": 1.0, "mqn8_c": 1.0, "mql8_c": -1.0, "h2o_p": 1.0}, "id": "DMSOR1pp", "gene_reaction_rule": "(STM1499 and STM1498 and STM1497 and STM1496) or (STM0964 and STM0965 and STM0966) or (STM4305_S and STM4306 and STM4307) or (STM2528 and STM2530 and STM2529)"}, {"subsystem": "Oxidative Phosphorylation", "name": "Dimethyl sulfoxide reductase (Demethylmenaquinol 8) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DMSOR2"]}, "metabolites": {"dmso_p": -1.0, "h2o_p": 1.0, "dms_p": 1.0, "2dmmq8_c": 1.0, "2dmmql8_c": -1.0}, "id": "DMSOR2pp", "gene_reaction_rule": "(STM0964 and STM0965 and STM0966) or (STM4305_S and STM4306 and STM4307) or (STM2528 and STM2530 and STM2529)"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Sodium transport out via proton antiport (cytoplasm to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAt3pp"]}, "metabolites": {"na1_p": 1.0, "na1_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "NAt3pp", "gene_reaction_rule": "STM0866 or STM1771 or STM1556"}, {"subsystem": "Histidine Metabolism", "name": "4 Imidazolone 5 propanoate propionase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["4IZ5PPH"]}, "metabolites": {"4iz5pp_c": -1.0, "h2o_c": -1.0, "nflgln_c": 1.0}, "id": "4IZ5PPH", "gene_reaction_rule": "STM0787"}, {"subsystem": "Histidine Metabolism", "name": "N Formimino L glutamate formiminohydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NFLGLNH"]}, "metabolites": {"h2o_c": -1.0, "nflgln_c": -1.0, "glu__L_c": 1.0, "foam_c": 1.0}, "id": "NFLGLNH", "gene_reaction_rule": "STM0788"}, {"subsystem": "Exchange", "name": "4 Aminobenzoate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_4abz_e"]}, "metabolites": {"4abz_e": -1.0}, "id": "EX_4abz_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "4 aminobenzoate extracellular to cytosol ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ABZtex"]}, "metabolites": {"4abz_e": -1.0, "4abz_c": 1.0}, "id": "ABZtex", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "Ferrioxamine B exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_feroxB_e"]}, "metabolites": {"feroxB_e": -1.0}, "id": "EX_feroxB_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "Ferrioxamine B fe exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_feroxBfe_e"]}, "metabolites": {"feroxBfe_e": -1.0}, "id": "EX_feroxBfe_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "Ferrioxamine E exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_feroxE_e"]}, "metabolites": {"feroxE_e": -1.0}, "id": "EX_feroxE_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "Ferrioxamine E fe exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_feroxEfe_e"]}, "metabolites": {"feroxEfe_e": -1.0}, "id": "EX_feroxEfe_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "Ferrioxamine G exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_feroxG_e"]}, "metabolites": {"feroxG_e": -1.0}, "id": "EX_feroxG_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "Ferrioxamine G fe exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_feroxGfe_e"]}, "metabolites": {"feroxGfe_e": -1.0}, "id": "EX_feroxGfe_e", "gene_reaction_rule": ""}, {"subsystem": "Transport Inner Membrane", "name": "Ferrioxamine B fe transport via ABC system periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FEROXBFEabcpp"]}, "metabolites": {"h2o_c": -1.0, "feroxBfe_p": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "feroxBfe_c": 1.0, "pi_c": 1.0}, "id": "FEROXBFEabcpp", "gene_reaction_rule": "STM0194 and STM0192 and STM0193"}, {"subsystem": "Transport Inner Membrane", "name": "Ferrioxamine E fe transport via ABC system periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FEROXEFEabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "feroxEfe_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "feroxEfe_c": 1.0, "pi_c": 1.0}, "id": "FEROXEFEabcpp", "gene_reaction_rule": "STM0194 and STM0192 and STM0193"}, {"subsystem": "Transport Inner Membrane", "name": "Ferrioxamine G fe transport via ABC system periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FEROXGFEabcpp"]}, "metabolites": {"h2o_c": -1.0, "feroxGfe_p": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "feroxGfe_c": 1.0, "pi_c": 1.0}, "id": "FEROXGFEabcpp", "gene_reaction_rule": "STM0194 and STM0192 and STM0193"}, {"subsystem": "Transport Outer Membrane", "name": "Ferrioxamine G fe transport via ton system extermal ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FEROXGFEtonex"]}, "metabolites": {"feroxGfe_e": -1.0, "h_c": 1.0, "h_p": -1.0, "feroxGfe_p": 1.0}, "id": "FEROXGFEtonex", "gene_reaction_rule": "STM0364 and (STM1737 and STM3158 and STM3159)"}, {"subsystem": "Transport Outer Membrane", "name": "Ferrioxamine B fe transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FEROXBFEtex"]}, "metabolites": {"feroxBfe_e": -1.0, "feroxBfe_p": 1.0}, "id": "FEROXBFEtex", "gene_reaction_rule": "STM0364"}, {"subsystem": "Transport Outer Membrane", "name": "Ferrioxamine E fe transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FEROXEFEtex"]}, "metabolites": {"feroxEfe_p": 1.0, "feroxEfe_e": -1.0}, "id": "FEROXEFEtex", "gene_reaction_rule": "STM0364"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Ferrioxamine G transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FEROXGtex"]}, "metabolites": {"feroxG_p": 1.0, "feroxG_e": -1.0}, "id": "FEROXGtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Ferrioxamine E transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FEROXEtex"]}, "metabolites": {"feroxE_e": -1.0, "feroxE_p": 1.0}, "id": "FEROXEtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Ferrioxamine B transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FEROXBtex"]}, "metabolites": {"feroxB_e": -1.0, "feroxB_p": 1.0}, "id": "FEROXBtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Transport Inner Membrane", "name": "Ferrioxamine B facilitated transport periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FEROXBtpp"]}, "metabolites": {"feroxB_p": -1.0, "feroxB_c": 1.0}, "id": "FEROXBtpp", "gene_reaction_rule": ""}, {"subsystem": "Transport Inner Membrane", "name": "Ferrioxamine E facilitated transport periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FEROXEtpp"]}, "metabolites": {"feroxE_c": 1.0, "feroxE_p": -1.0}, "id": "FEROXEtpp", "gene_reaction_rule": ""}, {"subsystem": "Transport Inner Membrane", "name": "Ferrioxamine G facilitated transport periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FEROXGtpp"]}, "metabolites": {"feroxG_p": -1.0, "feroxG_c": 1.0}, "id": "FEROXGtpp", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "Deoxy D Ribose exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_drib_e"]}, "metabolites": {"drib_e": -1.0}, "id": "EX_drib_e", "gene_reaction_rule": ""}, {"subsystem": "Transport Inner Membrane", "name": "Deoxy D ribose transport via proton symport periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DRIBtpp"]}, "metabolites": {"drib_p": -1.0, "h_c": 1.0, "h_p": -1.0, "drib_c": 1.0}, "id": "DRIBtpp", "gene_reaction_rule": "STM3792"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Deoxyribokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DRBK"]}, "metabolites": {"2dr5p_c": 1.0, "drib_c": -1.0, "atp_c": -1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "DRBK", "gene_reaction_rule": "STM3793"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Deoxyribose transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DRIBtex"]}, "metabolites": {"drib_e": -1.0, "drib_p": 1.0}, "id": "DRIBtex", "gene_reaction_rule": "STM0320 or STM0999 or STM1473 or STM2267"}, {"subsystem": "Cysteine Metabolism", "name": "S-sulfo-L-cysteine sulfite lyase ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SCYSSL"]}, "metabolites": {"cys__L_c": 1.0, "so3_c": 1.0, "slcys_c": -1.0, "h_c": 1.0, "gthrd_c": -2.0, "gthox_c": 1.0}, "id": "SCYSSL", "gene_reaction_rule": ""}, {"name": "O-acetyl-L-serine sulfhydrylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SLCYSS"]}, "metabolites": {"ac_c": 1.0, "acser_c": -1.0, "tsul_c": -1.0, "slcys_c": 1.0}, "id": "SLCYSS", "gene_reaction_rule": "STM2440"}, {"name": "Glutathione peridoxase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GSHPO"]}, "metabolites": {"h2o2_c": -1.0, "h2o_c": 2.0, "gthrd_c": -2.0, "gthox_c": 1.0}, "id": "GTHPi", "gene_reaction_rule": "STM1341"}, {"name": "2-hydroxyhepta-2,4-diene-1,7-dioate isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HHDDI"]}, "metabolites": {"2hh24dd_c": -1.0, "2oh3d_c": 1.0}, "id": "HHDDI_1", "gene_reaction_rule": "STM1101"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Ketoinositol reductase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["INOSR"]}, "metabolites": {"inost_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "h_c": 1.0, "2ins_c": 1.0}, "id": "INOSR", "gene_reaction_rule": "STM4433 or STM4425"}, {"name": "MMSAD3", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MMSAD3"]}, "metabolites": {"nadh_c": 1.0, "accoa_c": 1.0, "coa_c": -1.0, "nad_c": -1.0, "co2_c": 1.0, "msa_c": -1.0}, "id": "MMSAD3", "gene_reaction_rule": "STM4421"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Chitobiose-6-phosphate hydrolase", "upper_bound": 0.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHITPH"]}, "metabolites": {"acgam_c": 1.0, "h2o_c": -1.0, "acgam6p_c": 1.0, "chit6p_c": -1.0}, "id": "CHITPH", "gene_reaction_rule": "STM1316"}, {"subsystem": "Alternate Carbon metabolism", "name": "2-Deoxy-5-Keto-D-gluconate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["D5KGK"]}, "metabolites": {"d5kg_c": -1.0, "d5kgp_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "D5KGK", "gene_reaction_rule": "STM4420"}, {"subsystem": "Alternate Carbon metabolism", "name": "2-Deoxy-5-keto-D-gluconate 6-phosphate aldolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["D5KGPA"]}, "metabolites": {"dhap_c": 1.0, "d5kgp_c": -1.0, "msa_c": 1.0}, "id": "D5KGPA", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon metabolism", "name": "2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHEDAA"]}, "metabolites": {"24dhhed_c": -1.0, "sucsal_c": 1.0, "pyr_c": 1.0}, "id": "DHEDAA", "gene_reaction_rule": "STM1106 and STM2289"}, {"name": "D-2,3-Diketo 4-deoxy-epi-inositol dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DKDID"]}, "metabolites": {"h2o_c": -1.0, "d5kg_c": 1.0, "h_c": 1.0, "dkdi_c": -1.0}, "id": "DKDID", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-Inosose dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2INSD"]}, "metabolites": {"h2o_c": 1.0, "2ins_c": -1.0, "dkdi_c": 1.0}, "id": "2INSD", "gene_reaction_rule": "STM4424_S"}, {"subsystem": "Alternate Carbon Metabolism", "name": "D(-)-tartrate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DTARTD"]}, "metabolites": {"h2o_c": 1.0, "tartr__D_c": -1.0, "oaa_c": 1.0}, "id": "DTARTD", "gene_reaction_rule": "STM2949"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Nmn hydrolysis", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NMNR"]}, "metabolites": {"rnam_e": 1.0, "nmn_e": -1.0, "h2o_e": -1.0, "pi_e": 1.0}, "id": "NMNR", "gene_reaction_rule": "STM2949"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Ribosylnicotinamide kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RNMK"]}, "metabolites": {"rnam_c": -1.0, "nmn_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "RNMK", "gene_reaction_rule": "STM4580_S"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "O-antigen Acetyl-Transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OACT"]}, "metabolites": {"udcpo5_c": 1.0, "udcpo4_c": -1.0, "coa_c": 1.0, "accoa_c": -1.0}, "id": "OACT", "gene_reaction_rule": "STM2232"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Abequosyl transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UDCPAT"]}, "metabolites": {"cdp_c": 1.0, "udcpo4_c": 1.0, "cdpabeq_c": -1.0, "h_c": 1.0, "udcpgrm_c": -1.0}, "id": "UDCPAT", "gene_reaction_rule": "STM2087"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Mannosyl transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UDCPMT"]}, "metabolites": {"udcpgrm_c": 1.0, "gdpmann_c": -1.0, "udcpgr_c": -1.0, "gdp_c": 1.0, "h_c": 1.0}, "id": "UDCPMT", "gene_reaction_rule": "STM2086"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Rhamnosyl transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": 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"STM1314 and STM1312 and STM1313 and STM2431 and STM2432"}, {"subsystem": "Transport", "name": "Nicotinamide riboside transport into periplasm", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RNAMtex"]}, "metabolites": {"rnam_p": 1.0, "rnam_e": -1.0}, "id": "RNAMtex", "gene_reaction_rule": ""}, {"subsystem": "Transport", "name": "Nicotinamide riboside transport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RNAMtpp"]}, "metabolites": {"rnam_p": -1.0, "rnam_c": 1.0}, "id": "RNAMtpp", "gene_reaction_rule": "STM0757"}, {"subsystem": "Transport", "name": "O-antigen unit (O5) translocase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OAO5t3ex"]}, "metabolites": {"udcpo5_p": -1.0, "udcpo5_e": 1.0}, "id": "OAO5t3ex", "gene_reaction_rule": ""}, {"subsystem": "Transport", "name": "O-antigen unit (O5) translocase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OAO5t3pp"]}, "metabolites": {"udcpo5_c": -1.0, "udcpo5_p": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "OAO5t3pp", "gene_reaction_rule": "STM3926"}, {"subsystem": "Transport", "name": "Tricarballylate transport in via proton symport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TCBt2pp"]}, "metabolites": {"tcb_c": 1.0, "tcb_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "TCBt2pp", "gene_reaction_rule": "STM0689"}, {"subsystem": "Transport", "name": "Tricarballylate transport into periplasm", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TCBt2ex"]}, "metabolites": {"tcb_p": 1.0, "tcb_e": -1.0}, "id": "TCBt2ex", "gene_reaction_rule": ""}, {"subsystem": "Oxidative Phosphorylation", "name": "Trithionate Reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TTONR1pp"]}, "metabolites": {"mqn8_c": 1.0, "tton_p": -1.0, "tsul_p": 1.0, "so3_p": 1.0, "h_c": 4.0, "mql8_c": -1.0}, "id": "TTONR1pp", "gene_reaction_rule": "STM1383 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{"subsystem": "Nucleotide Salvage Pathway", "name": "3',5'-cyclic-nucleotide phosphodiesterase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["35PDE"]}, "metabolites": {"h2o_c": -1.0, "camp_c": -1.0, "h_c": 1.0, "amp_c": 1.0}, "id": "PDE1", "gene_reaction_rule": ""}, {"subsystem": "Histidine metabolism", "name": "Urocanate hydratase", "upper_bound": 0.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UROCANH"]}, "metabolites": {"4iz5pp_c": 1.0, "h2o_c": -1.0, "urocan_c": -1.0}, "id": "UROCANH", "gene_reaction_rule": ""}, {"subsystem": "lipopolysaccharide biosynthesis", "name": "DTDP-N-4-acetamido-4,6-dideoxy-D-galactose transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AADDFT"]}, "metabolites": {"unagamu_c": -1.0, "unagamuf_c": 1.0, "dtdp4aaddg_c": -1.0, "dtdp_c": 1.0, "h_c": 1.0}, "id": "AADDGT", "gene_reaction_rule": "STM3927"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Enterobactin 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{"original_bigg_ids": ["DHBSZ3tex"]}, "metabolites": {"23dhbzs3_p": -1.0, "23dhbzs3_e": 1.0}, "id": "DHBSZ3tex", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "23dhbsz3 Fe III sequestration", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHBSZ3FEexs"]}, "metabolites": {"fe3dhbzs3_e": 1.0, "23dhbzs3_e": -1.0, "fe3_e": -1.0}, "id": "DHBSZ3FEexs", "gene_reaction_rule": "s0001"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "23dhbsz3  Fe III import", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHBSZ3FEtonex"]}, "metabolites": {"fe3dhbzs3_e": -1.0, "h_p": -1.0, "fe3dhbzs3_p": 1.0, "h_c": 1.0}, "id": "DHBSZ3FEtonex", "gene_reaction_rule": "(STM2199 or STM0585 or STM2777) and (STM1737 and STM3159 and STM3158)"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "23dhbsz3 Fe III transport via ABC system periplasm", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHBSZ3FEabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "fe3dhbzs3_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "fe3dhbzs3_c": 1.0}, "id": "DHBSZ3FEabcpp", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Fe3dhbzs3 Fe III reduction and offloading", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FEDHBZS3R1"]}, "metabolites": {"fe2_c": 2.0, "fadh2_c": -1.0, "h_c": 2.0, "23dhbzs3_c": 2.0, "fe3dhbzs3_c": -2.0, "fad_c": 1.0}, "id": "FEDHBZS3R1", "gene_reaction_rule": "STM2775 or STM0586"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Fe3dhbzs3 Fe III reduction and offloading", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FEDHBZS3R2"]}, "metabolites": {"fe2_c": 2.0, "fmnh2_c": -1.0, "fmn_c": 1.0, "h_c": 2.0, "23dhbzs3_c": 2.0, "fe3dhbzs3_c": -2.0}, "id": "FEDHBZS3R2", "gene_reaction_rule": "STM2775 or STM0586"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Fe3dhbzs3 Fe III reduction and offloading", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FEDHBZS3R3"]}, "metabolites": {"rbflvrd_c": -1.0, "fe2_c": 2.0, "h_c": 2.0, "23dhbzs3_c": 2.0, "fe3dhbzs3_c": -2.0, "ribflv_c": 1.0}, "id": "FEDHBZS3R3", "gene_reaction_rule": "STM2775 or STM0586"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Salmochelin s2 secretion", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SALCHS2tex"]}, "metabolites": {"salchs2_e": 1.0, "salchs2_p": -1.0}, "id": "SALCHS2tex", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Salmochelin s2 Fe III sequestration", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SALCHS2FEexs"]}, "metabolites": {"salchs2fe_e": 1.0, "salchs2_e": -1.0, "fe3_e": -1.0}, "id": "SALCHS2FEexs", "gene_reaction_rule": "s0001"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Salmochelin s2 Fe III import", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SALCHS2FEtonex"]}, "metabolites": {"salchs2fe_e": -1.0, "h_c": 1.0, "h_p": -1.0, "salchs2fe_p": 1.0}, "id": "SALCHS2FEtonex", "gene_reaction_rule": "STM2777"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Salmochelin s2 Fe III transport via ABC system periplasm", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SALCHS2FEabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "salchs2fe_p": -1.0, "salchs2fe_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "SALCHS2FEabcpp", "gene_reaction_rule": "STM0594 and STM0590 and STM0592 and STM0591"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Salmochelin s2 Fe III reduction and offloading", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SALCHS2FER1"]}, "metabolites": {"fe2_c": 2.0, "salchs2_c": 2.0, "fadh2_c": -1.0, "salchs2fe_c": -2.0, "h_c": 2.0, "fad_c": 1.0}, "id": "SALCHS2FER1", "gene_reaction_rule": "STM2775"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Salmochelin s2 Fe III reduction and offloading", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SALCHS2FER2"]}, "metabolites": {"fe2_c": 2.0, "salchs2_c": 2.0, "fmnh2_c": -1.0, "salchs2fe_c": -2.0, "h_c": 2.0, "fmn_c": 1.0}, "id": "SALCHS2FER2", "gene_reaction_rule": "STM2775"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Salmochelin s2 Fe III reduction and offloading", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SALCHS2FER3"]}, "metabolites": {"rbflvrd_c": -1.0, "fe2_c": 2.0, "salchs2_c": 2.0, "salchs2fe_c": -2.0, "h_c": 2.0, "ribflv_c": 1.0}, "id": "SALCHS2FER3", "gene_reaction_rule": "STM2775"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Salmochelin s2 hydrolase", 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Ion Transport and Metabolism", "name": "Ferrioxamine Fe III reduction and offloading", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FEROXEFER2"]}, "metabolites": {"feroxE_c": 2.0, "fe2_c": 2.0, "fmnh2_c": -1.0, "fmn_c": 1.0, "h_c": 2.0, "feroxEfe_c": -2.0}, "id": "FEROXEFER2", "gene_reaction_rule": "STM3979"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Ferrioxamine Fe III reduction and offloading", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FEROXEFER3"]}, "metabolites": {"rbflvrd_c": -1.0, "feroxE_c": 2.0, "fe2_c": 2.0, "h_c": 2.0, "feroxEfe_c": -2.0, "ribflv_c": 1.0}, "id": "FEROXEFER3", "gene_reaction_rule": "STM3979"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Ferrioxamine Fe III reduction and offloading", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FEROXGFER1"]}, "metabolites": {"fe2_c": 2.0, "feroxG_c": 2.0, "fadh2_c": -1.0, "h_c": 2.0, 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"charge": 0, "formula": "C19H40NO7P1", "compartment": "c", "id": "2agpe140_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C14:1)", "notes": {"original_bigg_ids": ["2agpe141_p"]}, "charge": 0, "formula": "C19H38NO7P1", "compartment": "p", "id": "2agpe141_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C14:1)", "notes": {"original_bigg_ids": ["2agpe141_c"]}, "charge": 0, "formula": "C19H38NO7P1", "compartment": "c", "id": "2agpe141_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C16:0)", "notes": {"original_bigg_ids": ["2agpe160_c"]}, "charge": 0, "formula": "C21H44NO7P1", "compartment": "c", "id": "2agpe160_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C16:0)", "notes": {"original_bigg_ids": ["2agpe160_p"]}, "charge": 0, "formula": "C21H44NO7P1", "compartment": "p", "id": "2agpe160_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C16:1)", "notes": {"original_bigg_ids": ["2agpe161_c"]}, "charge": 0, "formula": "C21H42NO7P1", "compartment": "c", "id": "2agpe161_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C16:1)", "notes": {"original_bigg_ids": ["2agpe161_p"]}, "charge": 0, "formula": "C21H42NO7P1", "compartment": "p", "id": "2agpe161_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C18:0)", "notes": {"original_bigg_ids": ["2agpe180_p"]}, "charge": 0, "formula": "C23H48NO7P1", "compartment": "p", "id": "2agpe180_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C18:0)", "notes": {"original_bigg_ids": ["2agpe180_c"]}, "charge": 0, "formula": "C23H48NO7P1", "compartment": "c", "id": "2agpe180_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C18:1)", "notes": {"original_bigg_ids": ["2agpe181_p"]}, "charge": 0, "formula": "C23H46NO7P1", "compartment": "p", "id": "2agpe181_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C18:1)", "notes": {"original_bigg_ids": ["2agpe181_c"]}, "charge": 0, "formula": "C23H46NO7P1", "compartment": "c", "id": "2agpe181_c"}, {"name": "Diphosphate", "notes": {"original_bigg_ids": ["ppi_c"]}, "charge": -3, "formula": "HO7P2", "compartment": "c", "id": "ppi_c"}, {"name": "AMP", "notes": {"original_bigg_ids": ["amp_c"]}, "charge": -2, "formula": "C10H12N5O7P", "compartment": "c", "id": "amp_c"}, {"name": "Dodecanoate (n-C12:0)", "notes": {"original_bigg_ids": ["ddca_c"]}, "charge": -1, "formula": "C12H23O2", "compartment": "c", "id": "ddca_c"}, {"name": "Phosphatidylethanolamine (didodecanoyl, n-C12:0)", "notes": {"original_bigg_ids": ["pe120_c"]}, "charge": 0, "formula": "C29H58N1O8P1", "compartment": "c", "id": "pe120_c"}, {"name": "Phosphatidylethanolamine (ditetradecanoyl, n-C14:0)", "notes": {"original_bigg_ids": ["pe140_c"]}, "charge": 0, "formula": "C33H66N1O8P1", "compartment": "c", "id": "pe140_c"}, {"name": "Tetradecanoate (n-C14:0)", "notes": {"original_bigg_ids": ["ttdca_c"]}, "charge": -1, "formula": "C14H27O2", "compartment": "c", "id": "ttdca_c"}, {"name": "Phosphatidylethanolamine (ditetradec-7-enoyl, n-C14:1)", "notes": {"original_bigg_ids": ["pe141_c"]}, "charge": 0, "formula": "C33H62N1O8P1", "compartment": "c", "id": "pe141_c"}, {"name": "Tetradecenoate (n-C14:1)", "notes": {"original_bigg_ids": ["ttdcea_c"]}, "charge": -1, "formula": "C14H25O2", "compartment": "c", "id": "ttdcea_c"}, {"name": "Hexadecanoate (n-C16:0)", "notes": {"original_bigg_ids": ["hdca_c"]}, "charge": -1, "formula": "C16H31O2", "compartment": "c", "id": "hdca_c"}, {"name": "Phosphatidylethanolamine (dihexadecanoyl, n-C16:0)", "notes": {"original_bigg_ids": ["pe160_c"]}, "charge": 0, "formula": "C37H74N1O8P1", "compartment": "c", "id": "pe160_c"}, {"name": "Phosphatidylethanolamine (dihexadec-9enoyl, n-C16:1)", "notes": {"original_bigg_ids": ["pe161_c"]}, "charge": 0, "formula": "C37H70N1O8P1", "compartment": "c", "id": "pe161_c"}, {"name": "Hexadecenoate (n-C16:1)", "notes": {"original_bigg_ids": ["hdcea_c"]}, "charge": -1, "formula": "C16H29O2", "compartment": "c", "id": "hdcea_c"}, {"name": "Octadecanoate (n-C18:0)", "notes": {"original_bigg_ids": ["ocdca_c"]}, "charge": -1, "formula": "C18H35O2", "compartment": "c", "id": "ocdca_c"}, {"name": "Phosphatidylethanolamine (dioctadecanoyl, n-C18:0)", "notes": {"original_bigg_ids": ["pe180_c"]}, "charge": 0, "formula": "C41H82N1O8P1", "compartment": "c", "id": "pe180_c"}, {"name": "Octadecenoate (n-C18:1)", "notes": {"original_bigg_ids": ["ocdcea_c"]}, "charge": -1, "formula": "C18H33O2", "compartment": "c", "id": "ocdcea_c"}, {"name": "Phosphatidylethanolamine (dioctadec-11-enoyl, n-C18:1)", "notes": {"original_bigg_ids": ["pe181_c"]}, "charge": 0, "formula": "C41H78N1O8P1", "compartment": "c", "id": "pe181_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C12:0)", "notes": {"original_bigg_ids": ["2agpg120_p"]}, "charge": -1, "formula": "C18H36O9P1", "compartment": "p", "id": "2agpg120_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C12:0)", "notes": {"original_bigg_ids": ["2agpg120_c"]}, "charge": -1, "formula": "C18H36O9P1", "compartment": "c", "id": "2agpg120_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C14:0)", "notes": {"original_bigg_ids": ["2agpg140_c"]}, "charge": -1, "formula": "C20H40O9P1", "compartment": "c", "id": "2agpg140_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C14:0)", "notes": {"original_bigg_ids": ["2agpg140_p"]}, "charge": -1, "formula": "C20H40O9P1", "compartment": "p", "id": "2agpg140_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C14:1)", "notes": {"original_bigg_ids": ["2agpg141_c"]}, "charge": -1, "formula": "C20H38O9P1", "compartment": "c", "id": "2agpg141_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C14:1)", "notes": {"original_bigg_ids": ["2agpg141_p"]}, "charge": -1, "formula": "C20H38O9P1", "compartment": "p", "id": "2agpg141_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:0)", "notes": {"original_bigg_ids": ["2agpg160_p"]}, "charge": -1, "formula": "C22H44O9P1", "compartment": "p", "id": "2agpg160_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:0)", "notes": {"original_bigg_ids": ["2agpg160_c"]}, "charge": -1, "formula": "C22H44O9P1", "compartment": "c", "id": "2agpg160_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:1)", "notes": {"original_bigg_ids": ["2agpg161_p"]}, "charge": -1, "formula": "C22H42O9P1", "compartment": "p", "id": "2agpg161_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:1)", "notes": {"original_bigg_ids": ["2agpg161_c"]}, "charge": -1, "formula": "C22H42O9P1", "compartment": "c", "id": "2agpg161_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:0)", "notes": {"original_bigg_ids": ["2agpg180_c"]}, "charge": -1, "formula": "C24H48O9P1", "compartment": "c", "id": "2agpg180_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:0)", "notes": {"original_bigg_ids": ["2agpg180_p"]}, "charge": -1, "formula": "C24H48O9P1", "compartment": "p", "id": "2agpg180_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:1)", "notes": {"original_bigg_ids": ["2agpg181_c"]}, "charge": -1, "formula": "C24H46O9P1", "compartment": "c", "id": "2agpg181_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:1)", "notes": {"original_bigg_ids": ["2agpg181_p"]}, "charge": -1, "formula": "C24H46O9P1", "compartment": "p", "id": "2agpg181_p"}, {"name": "Phosphatidylglycerol (didodecanoyl, n-C12:0)", "notes": {"original_bigg_ids": ["pg120_c"]}, "charge": -1, "formula": "C30H58O10P1", "compartment": "c", "id": "pg120_c"}, {"name": "Phosphatidylglycerol (ditetradecanoyl, n-C14:0)", "notes": {"original_bigg_ids": ["pg140_c"]}, "charge": -1, "formula": "C34H66O10P1", "compartment": "c", "id": "pg140_c"}, {"name": "Phosphatidylglycerol (ditetradec-7-enoyl, n-C14:1)", "notes": {"original_bigg_ids": ["pg141_c"]}, "charge": -1, "formula": "C34H62O10P1", "compartment": "c", "id": "pg141_c"}, {"name": "Phosphatidylglycerol (dihexadecanoyl, n-C16:0)", "notes": {"original_bigg_ids": ["pg160_c"]}, "charge": -1, "formula": "C38H74O10P1", "compartment": "c", "id": "pg160_c"}, {"name": "Phosphatidylglycerol (dihexadec-9-enoyl, n-C16:1)", "notes": {"original_bigg_ids": ["pg161_c"]}, "charge": -1, "formula": "C38H70O10P1", "compartment": "c", "id": "pg161_c"}, {"name": "Phosphatidylglycerol (dioctadecanoyl, n-C18:0)", "notes": {"original_bigg_ids": ["pg180_c"]}, "charge": -1, "formula": "C42H82O10P1", "compartment": "c", "id": "pg180_c"}, {"name": "Phosphatidylglycerol (dioctadec-11-enoyl, n-C18:1)", "notes": {"original_bigg_ids": ["pg181_c"]}, "charge": -1, "formula": "C42H78O10P1", "compartment": "c", "id": "pg181_c"}, {"name": "D-Gluconate", "notes": {"original_bigg_ids": ["glcn_c"]}, "charge": -1, "formula": "C6H11O7", "compartment": "c", "id": "glcn_c"}, {"name": "Nicotinamide adenine dinucleotide", "notes": {"original_bigg_ids": ["nad_c"]}, "charge": -1, "formula": "C21H26N7O14P2", "compartment": "c", "id": "nad_c"}, {"name": "2-Dehydro-D-gluconate", "notes": {"original_bigg_ids": ["2dhglcn_c"]}, "charge": -1, "formula": "C6H9O7", "compartment": "c", "id": "2dhglcn_c"}, {"name": "Nicotinamide adenine dinucleotide - reduced", "notes": {"original_bigg_ids": ["nadh_c"]}, "charge": -2, "formula": "C21H27N7O14P2", "compartment": "c", "id": "nadh_c"}, {"name": "Nicotinamide adenine dinucleotide phosphate - reduced", "notes": {"original_bigg_ids": ["nadph_c"]}, "charge": -4, "formula": "C21H26N7O17P3", "compartment": "c", "id": "nadph_c"}, {"name": "Nicotinamide adenine dinucleotide phosphate", "notes": {"original_bigg_ids": ["nadp_c"]}, "charge": -3, "formula": "C21H25N7O17P3", "compartment": "c", "id": "nadp_c"}, {"name": "L-Idonate", "notes": {"original_bigg_ids": ["idon_L_c"]}, "charge": -1, "formula": "C6H11O7", "compartment": "c", "id": "idon__L_c"}, {"name": "2-Dehydro-L-gulonate", "notes": {"original_bigg_ids": ["2dhguln_c"]}, "charge": -1, "formula": "C6H9O7", "compartment": "c", "id": "2dhguln_c"}, {"name": "4-Amino-2-methyl-5-phosphomethylpyrimidine", "notes": {"original_bigg_ids": ["4ampm_c"]}, "charge": -2, "formula": "C6H8N3O4P", "compartment": "c", "id": "4ampm_c"}, {"name": "2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate", "notes": {"original_bigg_ids": ["2mahmp_c"]}, "charge": -3, "formula": "C6H8N3O7P2", "compartment": "c", "id": "2mahmp_c"}, {"name": "3,4-Dihydroxyphenylacetaldehyde", "notes": {"original_bigg_ids": ["34dhpac_p"]}, "charge": 0, "formula": "C8H8O3", "compartment": "p", "id": "34dhpac_p"}, {"name": "3,4-Dihydroxyphenylacetaldehyde", "notes": {"original_bigg_ids": ["34dhpac_e"]}, "charge": 0, "formula": "C8H8O3", "compartment": "e", "id": "34dhpac_e"}, {"name": "3'-AMP", "notes": {"original_bigg_ids": ["3amp_e"]}, "charge": -2, "formula": "C10H12N5O7P", "compartment": "e", "id": "3amp_e"}, {"name": "3'-cmp", "notes": {"original_bigg_ids": ["3cmp_e"]}, "charge": -2, "formula": "C9H12N3O8P", "compartment": "e", "id": "3cmp_e"}, {"name": "3'-GMP", "notes": {"original_bigg_ids": ["3gmp_e"]}, "charge": -2, "formula": "C10H12N5O8P", "compartment": "e", "id": "3gmp_e"}, {"name": "(R)-3-Hydroxydecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hdecACP_c"]}, "charge": -1, "formula": "C394H621O144N96P1S3", "compartment": "c", "id": "3hdecACP_c"}, {"name": "Trans-Dec-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["tdec2eACP_c"]}, "charge": -1, "formula": "C394H619O143N96P1S3", "compartment": "c", "id": "tdec2eACP_c"}, {"name": "(R)-3-Hydroxydodecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hddecACP_c"]}, "charge": -1, "formula": "C396H625O144N96P1S3", "compartment": "c", "id": "3hddecACP_c"}, {"name": "Trans-Dodec-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["tddec2eACP_c"]}, "charge": -1, "formula": "C396H623O143N96P1S3", "compartment": "c", "id": "tddec2eACP_c"}, {"name": "Trans-3-cis-5-dodecenoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["t3c5ddeceACP_c"]}, "charge": -1, "formula": "C396H621O143N96P1S3", "compartment": "c", "id": "t3c5ddeceACP_c"}, {"name": "(R)-3-hydroxy-cis-dodec-5-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hcddec5eACP_c"]}, "charge": -1, "formula": "C396H623O144N96P1S3", "compartment": "c", "id": "3hcddec5eACP_c"}, {"name": "Trans-Tetradec-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["tmrs2eACP_c"]}, "charge": -1, "formula": "C398H627O143N96P1S3", "compartment": "c", "id": "tmrs2eACP_c"}, {"name": "(R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hmrsACP_c"]}, "charge": -1, "formula": "C398H629O144N96P1S3", "compartment": "c", "id": "3hmrsACP_c"}, {"name": "Trans-3-cis-7-myristoleoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["t3c7mrseACP_c"]}, "charge": -1, "formula": "C398H625O143N96P1S3", "compartment": "c", "id": "t3c7mrseACP_c"}, {"name": "(R)-3-hydroxy-cis-myristol-7-eoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hcmrs7eACP_c"]}, "charge": -1, "formula": "C398H627O144N96P1S3", "compartment": "c", "id": "3hcmrs7eACP_c"}, {"name": "R-3-hydroxypalmitoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hpalmACP_c"]}, "charge": -1, "formula": "C400H633O144N96P1S3", "compartment": "c", "id": "3hpalmACP_c"}, {"name": "Trans-Hexadec-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["tpalm2eACP_c"]}, "charge": -1, "formula": "C400H631O143N96P1S3", "compartment": "c", "id": "tpalm2eACP_c"}, {"name": "Trans-3-cis-9-palmitoleoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["t3c9palmeACP_c"]}, "charge": -1, "formula": "C400H629O143N96P1S3", "compartment": "c", "id": "t3c9palmeACP_c"}, {"name": "(R)-3-hydroxy-cis-palm-9-eoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hcpalm9eACP_c"]}, "charge": -1, "formula": "C400H631O144N96P1S3", "compartment": "c", "id": "3hcpalm9eACP_c"}, {"name": "Trans-octadec-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["toctd2eACP_c"]}, "charge": -1, "formula": "C402H635O143N96P1S3", "compartment": "c", "id": "toctd2eACP_c"}, {"name": "(R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hoctaACP_c"]}, "charge": -1, "formula": "C402H637O144N96P1S3", "compartment": "c", "id": "3hoctaACP_c"}, {"name": "(R)-3-hydroxy-cis-vacc-11-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hcvac11eACP_c"]}, "charge": -1, "formula": "C402H635O144N96P1S3", "compartment": "c", "id": "3hcvac11eACP_c"}, {"name": "Trans-3-cis-11-vacceoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["t3c11vaceACP_c"]}, "charge": -1, "formula": "C402H633O143N96P1S3", "compartment": "c", "id": "t3c11vaceACP_c"}, {"name": "(3R)-3-Hydroxyacyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3haACP_c"]}, "charge": -1, "formula": "C388H609O144N96P1S3", "compartment": "c", "id": "3haACP_c"}, {"name": "But-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["but2eACP_c"]}, "charge": -1, "formula": "C388H607O143N96P1S3", "compartment": "c", "id": "but2eACP_c"}, {"name": "(R)-3-Hydroxyhexanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hhexACP_c"]}, "charge": -1, "formula": "C390H613O144N96P1S3", "compartment": "c", "id": "3hhexACP_c"}, {"name": "Trans-Hex-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["thex2eACP_c"]}, "charge": -1, "formula": "C390H611O143N96P1S3", "compartment": "c", "id": "thex2eACP_c"}, {"name": "Trans-Oct-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["toct2eACP_c"]}, "charge": -1, "formula": "C392H615O143N96P1S3", "compartment": "c", "id": "toct2eACP_c"}, {"name": "(R)-3-Hydroxyoctanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hoctACP_c"]}, "charge": -1, "formula": "C392H617O144N96P1S3", "compartment": "c", "id": "3hoctACP_c"}, {"name": "3-Dehydro-L-gulonate", "notes": {"original_bigg_ids": ["3dhguln_c"]}, "charge": -1, "formula": "C6H9O7", "compartment": "c", "id": "3dhguln_c"}, {"name": "3-keto-L-gulonate-6-phosphate", "notes": {"original_bigg_ids": ["3dhgulnp_c"]}, "charge": -3, "formula": "C6H8O10P", "compartment": "c", "id": "3dhgulnp_c"}, {"name": "Uridine", "notes": {"original_bigg_ids": ["uri_p"]}, "charge": 0, "formula": "C9H12N2O6", "compartment": "p", "id": "uri_p"}, {"name": "Phosphate", "notes": {"original_bigg_ids": ["pi_p"]}, "charge": -2, "formula": "HO4P", "compartment": "p", "id": "pi_p"}, {"name": "Cytidine", "notes": {"original_bigg_ids": ["cytd_p"]}, "charge": 0, "formula": "C9H13N3O5", "compartment": "p", "id": "cytd_p"}, {"name": "Adenosine", "notes": {"original_bigg_ids": ["adn_p"]}, "charge": 0, "formula": "C10H13N5O4", "compartment": "p", "id": "adn_p"}, {"name": "Guanosine", "notes": {"original_bigg_ids": ["gsn_p"]}, "charge": 0, "formula": "C10H13N5O5", "compartment": "p", "id": "gsn_p"}, {"name": "3-Oxodecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3odecACP_c"]}, "charge": -1, "formula": "C394H619O144N96P1S3", "compartment": "c", "id": "3odecACP_c"}, {"name": "3-Oxododecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3oddecACP_c"]}, "charge": -1, "formula": "C396H623O144N96P1S3", "compartment": "c", "id": "3oddecACP_c"}, {"name": "3-oxo-cis-dodec-5-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ocddec5eACP_c"]}, "charge": -1, "formula": "C396H621O144N96P1S3", "compartment": "c", "id": "3ocddec5eACP_c"}, {"name": "3-Oxotetradecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3omrsACP_c"]}, "charge": -1, "formula": "C398H627O144N96P1S3", "compartment": "c", "id": "3omrsACP_c"}, {"name": "3-oxo-cis-myristol-7-eoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ocmrs7eACP_c"]}, "charge": -1, "formula": "C398H625O144N96P1S3", "compartment": "c", "id": "3ocmrs7eACP_c"}, {"name": "3-Oxohexadecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3opalmACP_c"]}, "charge": -1, "formula": "C400H631O144N96P1S3", "compartment": "c", "id": "3opalmACP_c"}, {"name": "3-oxo-cis-palm-9-eoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ocpalm9eACP_c"]}, "charge": -1, "formula": "C400H629O144N96P1S3", "compartment": "c", "id": "3ocpalm9eACP_c"}, {"name": "3-Oxooctadecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ooctdACP_c"]}, "charge": -1, "formula": "C402H635O144N96P1S3", "compartment": "c", "id": "3ooctdACP_c"}, {"name": "3-oxo-cis-vacc-11-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ocvac11eACP_c"]}, "charge": -1, "formula": "C402H633O144N96P1S3", "compartment": "c", "id": "3ocvac11eACP_c"}, {"name": "Acetoacetyl-ACP", "notes": {"original_bigg_ids": ["actACP_c"]}, "charge": -1, "formula": "C388H607O144N96P1S3", "compartment": "c", "id": "actACP_c"}, {"name": "3-Oxohexanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ohexACP_c"]}, "charge": -1, "formula": "C390H611O144N96P1S3", "compartment": "c", "id": "3ohexACP_c"}, {"name": "3-Oxooctanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ooctACP_c"]}, "charge": -1, "formula": "C392H615O144N96P1S3", "compartment": "c", "id": "3ooctACP_c"}, {"name": "Acyl carrier protein", "notes": {"original_bigg_ids": ["ACP_c"]}, "charge": -1, "formula": "C384H603N96O142P1S3", "compartment": "c", "id": "ACP_c"}, {"name": "Octanoyl-ACP (n-C8:0ACP)", "notes": {"original_bigg_ids": ["ocACP_c"]}, "charge": -1, "formula": "C392H617O143N96P1S3", "compartment": "c", "id": "ocACP_c"}, {"name": "Malonyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["malACP_c"]}, "charge": -2, "formula": "C387H604O145N96P1S3", "compartment": "c", "id": "malACP_c"}, {"name": "CO2", "notes": {"original_bigg_ids": ["co2_c"]}, "charge": 0, "formula": "CO2", "compartment": "c", "id": "co2_c"}, {"name": "Decanoyl-ACP (n-C10:0ACP)", "notes": {"original_bigg_ids": ["dcaACP_c"]}, "charge": -1, "formula": "C394H621O143N96P1S3", "compartment": "c", "id": "dcaACP_c"}, {"name": "Cis-dec-3-enoyl-[acyl-carrier protein] (n-C10:1)", "notes": {"original_bigg_ids": ["cdec3eACP_c"]}, "charge": -1, "formula": "C394H619O143N96P1S3", "compartment": "c", "id": "cdec3eACP_c"}, {"name": "Dodecanoyl-ACP (n-C12:0ACP)", "notes": {"original_bigg_ids": ["ddcaACP_c"]}, "charge": -1, "formula": "C396H625O143N96P1S3", "compartment": "c", "id": "ddcaACP_c"}, {"name": "Cis-dodec-5-enoyl-[acyl-carrier protein] (n-C12:1)", "notes": {"original_bigg_ids": ["cddec5eACP_c"]}, "charge": -1, "formula": "C396H623O143N96P1S3", "compartment": "c", "id": "cddec5eACP_c"}, {"name": "Myristoyl-ACP (n-C14:0ACP)", "notes": {"original_bigg_ids": ["myrsACP_c"]}, "charge": -1, "formula": "C398H629O143N96P1S3", "compartment": "c", "id": "myrsACP_c"}, {"name": "Cis-tetradec-7-enoyl-[acyl-carrier protein] (n-C14:1)", "notes": {"original_bigg_ids": ["tdeACP_c"]}, "charge": -1, "formula": "C398H627O143N96P1S3", "compartment": "c", "id": "tdeACP_c"}, {"name": "Palmitoyl-ACP (n-C16:0ACP)", "notes": {"original_bigg_ids": ["palmACP_c"]}, "charge": -1, "formula": "C400H633O143N96P1S3", "compartment": "c", "id": "palmACP_c"}, {"name": "Cis-hexadec-9-enoyl-[acyl-carrier protein] (n-C16:1)", "notes": {"original_bigg_ids": ["hdeACP_c"]}, "charge": -1, "formula": "C400H631O143N96P1S3", "compartment": "c", "id": "hdeACP_c"}, {"name": "Butyryl-ACP (n-C4:0ACP)", "notes": {"original_bigg_ids": ["butACP_c"]}, "charge": -1, "formula": "C388H609O143N96P1S3", "compartment": "c", "id": "butACP_c"}, {"name": "Hexanoyl-ACP (n-C6:0ACP)", "notes": {"original_bigg_ids": ["hexACP_c"]}, "charge": -1, "formula": "C390H613O143N96P1S3", "compartment": "c", "id": "hexACP_c"}, {"name": "L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate", "notes": {"original_bigg_ids": ["LalaDgluMdap_c"]}, "charge": -1, "formula": "C15H25N4O8", "compartment": "c", "id": "LalaDgluMdap_c"}, {"name": "L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate", "notes": {"original_bigg_ids": ["LalaDgluMdap_p"]}, "charge": -1, "formula": "C15H25N4O8", "compartment": "p", "id": "LalaDgluMdap_p"}, {"name": "L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate", "notes": {"original_bigg_ids": ["LalaDgluMdap_e"]}, "charge": -1, "formula": "C15H25N4O8", "compartment": "e", "id": "LalaDgluMdap_e"}, {"name": "3'-UMP", "notes": {"original_bigg_ids": ["3ump_e"]}, "charge": -2, "formula": "C9H11N2O9P", "compartment": "e", "id": "3ump_e"}, {"name": "4-Hydroxyphenylacetaldehyde", "notes": {"original_bigg_ids": ["4hoxpacd_e"]}, "charge": 0, "formula": "C8H8O2", "compartment": "e", "id": "4hoxpacd_e"}, {"name": "4-Hydroxyphenylacetaldehyde", "notes": {"original_bigg_ids": ["4hoxpacd_p"]}, "charge": 0, "formula": "C8H8O2", "compartment": "p", "id": "4hoxpacd_p"}, {"name": "4-Hydroxy-L-threonine", "notes": {"original_bigg_ids": ["4hthr_c"]}, "charge": 0, "formula": "C4H9NO4", "compartment": "c", "id": "4hthr_c"}, {"name": "O-Phospho-4-hydroxy-L-threonine", "notes": {"original_bigg_ids": ["phthr_c"]}, "charge": -2, "formula": "C4H8NO7P", "compartment": "c", "id": "phthr_c"}, {"name": "D-Alanine", "notes": {"original_bigg_ids": ["ala_D_c"]}, "charge": 0, "formula": "C3H7NO2", "compartment": "c", "id": "ala__D_c"}, {"name": "L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine", "notes": {"original_bigg_ids": ["LalaDgluMdapDala_c"]}, "charge": -1, "formula": "C18H30N5O9", "compartment": "c", "id": "LalaDgluMdapDala_c"}, {"name": "L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine", "notes": {"original_bigg_ids": ["LalaDgluMdapDala_p"]}, "charge": -1, "formula": "C18H30N5O9", "compartment": "p", "id": "LalaDgluMdapDala_p"}, {"name": "D-Alanine", "notes": {"original_bigg_ids": ["ala_D_p"]}, "charge": 0, "formula": "C3H7NO2", "compartment": "p", "id": "ala__D_p"}, {"name": "L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine", "notes": {"original_bigg_ids": ["LalaDgluMdapDala_e"]}, "charge": -1, "formula": "C18H30N5O9", "compartment": "e", "id": "LalaDgluMdapDala_e"}, {"name": "5-Dehydro-D-gluconate", "notes": {"original_bigg_ids": ["5dglcn_c"]}, "charge": -1, "formula": "C6H9O7", "compartment": "c", "id": "5dglcn_c"}, {"name": "5-Dehydro-D-gluconate", "notes": {"original_bigg_ids": ["5dglcn_p"]}, "charge": -1, "formula": "C6H9O7", "compartment": "p", "id": "5dglcn_p"}, {"name": "5-Dehydro-D-gluconate", "notes": {"original_bigg_ids": ["5dglcn_e"]}, "charge": -1, "formula": "C6H9O7", "compartment": "e", "id": "5dglcn_e"}, {"name": "5'-deoxyribose", "notes": {"original_bigg_ids": ["5drib_c"]}, "charge": 0, "formula": "C5H10O4", "compartment": "c", "id": "5drib_c"}, {"name": "5'-Deoxyadenosine", "notes": {"original_bigg_ids": ["dad_5_c"]}, "charge": 0, "formula": "C10H13N5O3", "compartment": "c", "id": "dad_5_c"}, {"name": "Adenine", "notes": {"original_bigg_ids": ["ade_c"]}, "charge": 0, "formula": "C5H5N5", "compartment": "c", "id": "ade_c"}, {"name": "D-Arabinose 5-phosphate", "notes": {"original_bigg_ids": ["ara5p_c"]}, "charge": -2, "formula": "C5H9O8P", "compartment": "c", "id": "ara5p_c"}, {"name": "D-Ribulose 5-phosphate", "notes": {"original_bigg_ids": ["ru5p_D_c"]}, "charge": -2, "formula": "C5H9O8P", "compartment": "c", "id": "ru5p__D_c"}, {"name": "Cis-octadec-11-enoyl-[acyl-carrier protein] (n-C18:1)", "notes": {"original_bigg_ids": ["octeACP_c"]}, "charge": -1, "formula": "C402H635O143N96P1S3", "compartment": "c", "id": "octeACP_c"}, {"name": "Octadecanoyl-ACP (n-C18:0ACP)", "notes": {"original_bigg_ids": ["ocdcaACP_c"]}, "charge": -1, "formula": "C402H637O143N96P1S3", "compartment": "c", "id": "ocdcaACP_c"}, {"name": "Decanoate (n-C10:0)", "notes": {"original_bigg_ids": ["dca_c"]}, "charge": -1, "formula": "C10H19O2", "compartment": "c", "id": "dca_c"}, {"name": "Octanoate (n-C8:0)", "notes": {"original_bigg_ids": ["octa_c"]}, "charge": -1, "formula": "C8H15O2", "compartment": "c", "id": "octa_c"}, {"name": "O2", "notes": {"original_bigg_ids": ["o2_c"]}, "charge": 0, "formula": "O2", "compartment": "c", "id": "o2_c"}, {"name": "Aminoacetone", "notes": {"original_bigg_ids": ["aact_c"]}, "charge": 1, "formula": "C3H8NO", "compartment": "c", "id": "aact_c"}, {"name": "Ammonium", "notes": {"original_bigg_ids": ["nh4_c"]}, "charge": 1, "formula": "H4N", "compartment": "c", "id": "nh4_c"}, {"name": "Methylglyoxal", "notes": {"original_bigg_ids": ["mthgxl_c"]}, "charge": 0, "formula": "C3H4O2", "compartment": "c", "id": "mthgxl_c"}, {"name": "Hydrogen peroxide", "notes": {"original_bigg_ids": ["h2o2_c"]}, "charge": 0, "formula": "H2O2", "compartment": "c", "id": "h2o2_c"}, {"name": "Maltohexaose", "notes": {"original_bigg_ids": ["malthx_c"]}, "charge": 0, "formula": "C36H62O31", "compartment": "c", "id": "malthx_c"}, {"name": "Maltohexaose", "notes": {"original_bigg_ids": ["malthx_p"]}, "charge": 0, "formula": "C36H62O31", "compartment": "p", "id": "malthx_p"}, {"name": "D-Glucose 6-phosphate", "notes": {"original_bigg_ids": ["g6p_c"]}, "charge": -2, "formula": "C6H11O9P", "compartment": "c", "id": "g6p_c"}, {"name": "Hydroquinone", "notes": {"original_bigg_ids": ["hqn_c"]}, "charge": 0, "formula": "C6H6O2", "compartment": "c", "id": "hqn_c"}, {"name": "Arbutin 6-phosphate", "notes": {"original_bigg_ids": ["arbt6p_c"]}, "charge": -2, "formula": "C12H15O10P", "compartment": "c", "id": "arbt6p_c"}, {"name": "4-Aminobutanoate", "notes": {"original_bigg_ids": ["4abut_c"]}, "charge": 0, "formula": "C4H9NO2", "compartment": "c", "id": "4abut_c"}, {"name": "2-Oxoglutarate", "notes": {"original_bigg_ids": ["akg_c"]}, "charge": -2, "formula": "C5H4O5", "compartment": "c", "id": "akg_c"}, {"name": "L-Glutamate", "notes": {"original_bigg_ids": ["glu_L_c"]}, "charge": -1, "formula": "C5H8NO4", "compartment": "c", "id": "glu__L_c"}, {"name": "Succinic semialdehyde", "notes": {"original_bigg_ids": ["sucsal_c"]}, "charge": -1, "formula": "C4H5O3", "compartment": "c", "id": "sucsal_c"}, {"name": "4-Aminobutanal", "notes": {"original_bigg_ids": ["4abutn_c"]}, "charge": 1, "formula": "C4H10NO", "compartment": "c", "id": "4abutn_c"}, {"name": "4-Aminobutanoate", "notes": {"original_bigg_ids": ["4abut_p"]}, "charge": 0, "formula": "C4H9NO2", "compartment": "p", "id": "4abut_p"}, {"name": "4-Aminobutanoate", "notes": {"original_bigg_ids": ["4abut_e"]}, "charge": 0, "formula": "C4H9NO2", "compartment": "e", "id": "4abut_e"}, {"name": "Acetoacetate", "notes": {"original_bigg_ids": ["acac_e"]}, "charge": -1, "formula": "C4H5O3", "compartment": "e", "id": "acac_e"}, {"name": "Acetoacetate", "notes": {"original_bigg_ids": ["acac_p"]}, "charge": -1, "formula": "C4H5O3", "compartment": "p", "id": "acac_p"}, {"name": "Acetyl-CoA", "notes": {"original_bigg_ids": ["accoa_c"]}, "charge": -4, "formula": "C23H34N7O17P3S", "compartment": "c", "id": "accoa_c"}, {"name": "Coenzyme A", "notes": {"original_bigg_ids": ["coa_c"]}, "charge": -4, "formula": "C21H32N7O16P3S", "compartment": "c", "id": "coa_c"}, {"name": "Acetaldehyde", "notes": {"original_bigg_ids": ["acald_c"]}, "charge": 0, "formula": "C2H4O", "compartment": "c", "id": "acald_c"}, {"name": "Acetaldehyde", "notes": {"original_bigg_ids": ["acald_e"]}, "charge": 0, "formula": "C2H4O", "compartment": "e", "id": "acald_e"}, {"name": "Acetaldehyde", "notes": {"original_bigg_ids": ["acald_p"]}, "charge": 0, "formula": "C2H4O", "compartment": "p", "id": "acald_p"}, {"name": "Adenosyl cobinamide phosphate", "notes": {"original_bigg_ids": ["adocbip_c"]}, "charge": -1, "formula": "C58H83CoN16O14P", "compartment": "c", "id": "adocbip_c"}, {"name": "Adenosine-GDP-cobinamide", "notes": {"original_bigg_ids": ["agdpcbi_c"]}, "charge": -1, "formula": "C68H95CoN21O21P2", "compartment": "c", "id": "agdpcbi_c"}, {"name": "GTP", "notes": {"original_bigg_ids": ["gtp_c"]}, "charge": -4, "formula": "C10H12N5O14P3", "compartment": "c", "id": "gtp_c"}, {"name": "Malonyl-CoA", "notes": {"original_bigg_ids": ["malcoa_c"]}, "charge": -5, "formula": "C24H33N7O19P3S", "compartment": "c", "id": "malcoa_c"}, {"name": "Bicarbonate", "notes": {"original_bigg_ids": ["hco3_c"]}, "charge": -1, "formula": "CHO3", "compartment": "c", "id": "hco3_c"}, {"name": "Propionate (n-C3:0)", "notes": {"original_bigg_ids": ["ppa_c"]}, "charge": -1, "formula": "C3H5O2", "compartment": "c", "id": "ppa_c"}, {"name": "Propanoyl-CoA", "notes": {"original_bigg_ids": ["ppcoa_c"]}, "charge": -4, "formula": "C24H36N7O17P3S", "compartment": "c", "id": "ppcoa_c"}, {"name": "N-Acetyl-D-galactosamine 1-phosphate", "notes": {"original_bigg_ids": ["acgal1p_p"]}, "charge": -2, "formula": "C8H14NO9P", "compartment": "p", "id": "acgal1p_p"}, {"name": "N-Acetyl-D-galactosamine", "notes": {"original_bigg_ids": ["acgal_p"]}, "charge": 0, "formula": "C8H15NO6", "compartment": "p", "id": "acgal_p"}, {"name": "N-Acetyl-D-galactosamine 1-phosphate", "notes": {"original_bigg_ids": ["acgal1p_e"]}, "charge": -2, "formula": "C8H14NO9P", "compartment": "e", "id": "acgal1p_e"}, {"name": "N-Acetyl-D-galactosamine", "notes": {"original_bigg_ids": ["acgal_e"]}, 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{"name": "KDO(2)-lipid IV(A) with palmitoleoyl", "notes": {"original_bigg_ids": ["kdo2lipid4p_c"]}, "charge": -6, "formula": "C100H176N2O38P2", "compartment": "c", "id": "kdo2lipid4p_c"}, {"name": "Cold adapted KDO(2)-lipid (A)", "notes": {"original_bigg_ids": ["lipa_cold_c"]}, "charge": -6, "formula": "C114H202N2O39P2", "compartment": "c", "id": "lipa_cold_c"}, {"name": "Phosphoethanolamine KDO(2)-lipid (A)", "notes": {"original_bigg_ids": ["enlipa_p"]}, "charge": -6, "formula": "C112H202N3O42P3", "compartment": "p", "id": "enlipa_p"}, {"name": "Phosphoethanolamine KDO(2)-lipid (A)", "notes": {"original_bigg_ids": ["enlipa_e"]}, "charge": -6, "formula": "C112H202N3O42P3", "compartment": "e", "id": "enlipa_e"}, {"name": "D-Glycerate 2-phosphate", "notes": {"original_bigg_ids": ["2pg_c"]}, "charge": -3, "formula": "C3H4O7P", "compartment": "c", "id": "2pg_c"}, {"name": "L-seryl-AMP", "notes": {"original_bigg_ids": ["seramp_c"]}, "charge": 0, "formula": "C13H19N6O9P", "compartment": "c", "id": "seramp_c"}, {"name": "Enterochelin", "notes": {"original_bigg_ids": ["enter_c"]}, "charge": 0, "formula": "C30H27N3O15", "compartment": "c", "id": "enter_c"}, {"name": "Ethanolamine", "notes": {"original_bigg_ids": ["etha_c"]}, "charge": 1, "formula": "C2H8NO", "compartment": "c", "id": "etha_c"}, {"name": "Ethanolamine", "notes": {"original_bigg_ids": ["etha_p"]}, "charge": 1, "formula": "C2H8NO", "compartment": "p", "id": "etha_p"}, {"name": "Ethanolamine", "notes": {"original_bigg_ids": ["etha_e"]}, "charge": 1, "formula": "C2H8NO", "compartment": "e", "id": "etha_e"}, {"name": "Ethanesulfonate", "notes": {"original_bigg_ids": ["ethso3_e"]}, "charge": -1, "formula": "C2H5O3S", "compartment": "e", "id": "ethso3_e"}, {"name": "Ethanesulfonate", "notes": {"original_bigg_ids": ["ethso3_p"]}, "charge": -1, "formula": "C2H5O3S", "compartment": "p", "id": "ethso3_p"}, {"name": "Ethanol", "notes": {"original_bigg_ids": ["etoh_c"]}, "charge": 0, "formula": "C2H6O", "compartment": "c", "id": "etoh_c"}, {"name": "Ethanol", "notes": {"original_bigg_ids": ["etoh_p"]}, "charge": 0, "formula": "C2H6O", "compartment": "p", "id": "etoh_p"}, {"name": "Ethanol", "notes": {"original_bigg_ids": ["etoh_e"]}, "charge": 0, "formula": "C2H6O", "compartment": "e", "id": "etoh_e"}, {"name": "Chitobiose", "notes": {"original_bigg_ids": ["chitob_e"]}, "charge": 0, "formula": "C16H28N2O11", "compartment": "e", "id": "chitob_e"}, {"name": "Pyridoxine", "notes": {"original_bigg_ids": ["pydxn_e"]}, "charge": 0, "formula": "C8H11NO3", "compartment": "e", "id": "pydxn_e"}, {"name": "Pyridoxal", "notes": {"original_bigg_ids": ["pydx_e"]}, "charge": 0, "formula": "C8H9NO3", "compartment": "e", "id": "pydx_e"}, {"name": "3-hydroxycinnamic acid", "notes": {"original_bigg_ids": ["3hcinnm_e"]}, "charge": -1, "formula": "C9H7O3", "compartment": "e", "id": "3hcinnm_e"}, {"name": "3-(3-hydroxy-phenyl)propionate", "notes": {"original_bigg_ids": ["3hpppn_e"]}, "charge": -1, "formula": "C9H9O3", "compartment": "e", "id": "3hpppn_e"}, {"name": "Silver", "notes": {"original_bigg_ids": ["ag_e"]}, "charge": 1, "formula": "Ag", "compartment": "e", "id": "ag_e"}, {"name": "Enterochelin", "notes": {"original_bigg_ids": ["enter_e"]}, "charge": 0, "formula": "C30H27N3O15", "compartment": "e", "id": "enter_e"}, {"name": "D-Fructose 6-phosphate", "notes": {"original_bigg_ids": ["f6p_e"]}, "charge": -2, "formula": "C6H11O9P", "compartment": "e", "id": "f6p_e"}, {"name": "Formaldehyde", "notes": {"original_bigg_ids": ["fald_e"]}, "charge": 0, "formula": "CH2O", "compartment": "e", "id": "fald_e"}, {"name": "Fe2+", "notes": {"original_bigg_ids": ["fe2_e"]}, "charge": 2, "formula": "Fe", "compartment": "e", "id": "fe2_e"}, {"name": "Fe(III)dicitrate", "notes": {"original_bigg_ids": ["fe3dcit_e"]}, "charge": -3, "formula": "C12H10FeO14", "compartment": "e", "id": "fe3dcit_e"}, {"name": "Ferric 2,3-dihydroxybenzoylserine", "notes": {"original_bigg_ids": ["fe3dhbzs_e"]}, "charge": 2, "formula": "C10FeH11NO6", "compartment": "e", "id": "fe3dhbzs_e"}, {"name": "Fe(III)hydroxamate", "notes": {"original_bigg_ids": ["fe3hox_e"]}, "charge": 0, "formula": "C9H18O6N3Fe", "compartment": "e", "id": "fe3hox_e"}, {"name": "Fe(III)hydoxamate, unloaded", "notes": {"original_bigg_ids": ["fe3hox_un_e"]}, "charge": -3, "formula": "C9H18O6N3", "compartment": "e", "id": "fe3hox_un_e"}, {"name": "Ferrichrome", "notes": {"original_bigg_ids": ["fecrm_e"]}, "charge": 0, "formula": "C27H42FeN9O12", "compartment": "e", "id": "fecrm_e"}, {"name": "Ferrichrome minus Fe(III)", "notes": {"original_bigg_ids": ["fecrm_un_e"]}, "charge": -3, "formula": "C27H42N9O12", "compartment": "e", "id": "fecrm_un_e"}, {"name": "Fe-enterobactin", "notes": {"original_bigg_ids": ["feenter_e"]}, "charge": 3, "formula": "C30H27FeN3O15", "compartment": "e", "id": "feenter_e"}, {"name": "Ferroxamine", "notes": {"original_bigg_ids": ["feoxam_e"]}, "charge": 1, "formula": "C25FeH46N6O8", "compartment": "e", "id": "feoxam_e"}, 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"Potassium", "notes": {"original_bigg_ids": ["k_e"]}, "charge": 1, "formula": "K", "compartment": "e", "id": "k_e"}, {"name": "KDO(2)-lipid IV(A)", "notes": {"original_bigg_ids": ["kdo2lipid4_e"]}, "charge": -6, "formula": "C84H148N2O37P2", "compartment": "e", "id": "kdo2lipid4_e"}, {"name": "L-Lactate", "notes": {"original_bigg_ids": ["lac_L_e"]}, "charge": -1, "formula": "C3H5O3", "compartment": "e", "id": "lac__L_e"}, {"name": "Lactose", "notes": {"original_bigg_ids": ["lcts_e"]}, "charge": 0, "formula": "C12H22O11", "compartment": "e", "id": "lcts_e"}, {"name": "L-Leucine", "notes": {"original_bigg_ids": ["leu_L_e"]}, "charge": 0, "formula": "C6H13NO2", "compartment": "e", "id": "leu__L_e"}, {"name": "KDO(2)-lipid (A)", "notes": {"original_bigg_ids": ["lipa_e"]}, "charge": -6, "formula": "C110H196N2O39P2", "compartment": "e", "id": "lipa_e"}, {"name": "L-Lysine", "notes": {"original_bigg_ids": ["lys_L_e"]}, "charge": 1, "formula": "C6H15N2O2", "compartment": "e", "id": "lys__L_e"}, 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{"name": "Maltotetraose", "notes": {"original_bigg_ids": ["maltttr_e"]}, "charge": 0, "formula": "C24H42O21", "compartment": "e", "id": "maltttr_e"}, {"name": "D-Mannose 6-phosphate", "notes": {"original_bigg_ids": ["man6p_e"]}, "charge": -2, "formula": "C6H11O9P", "compartment": "e", "id": "man6p_e"}, {"name": "D-Mannose", "notes": {"original_bigg_ids": ["man_e"]}, "charge": 0, "formula": "C6H12O6", "compartment": "e", "id": "man_e"}, {"name": "2(alpha-D-Mannosyl)-D-glycerate", "notes": {"original_bigg_ids": ["manglyc_e"]}, "charge": -1, "formula": "C9H15O9", "compartment": "e", "id": "manglyc_e"}, {"name": "Melibiose", "notes": {"original_bigg_ids": ["melib_e"]}, "charge": 0, "formula": "C12H22O11", "compartment": "e", "id": "melib_e"}, {"name": "D-Methionine", "notes": {"original_bigg_ids": ["met_D_e"]}, "charge": 0, "formula": "C5H10NO2S", "compartment": "e", "id": "met__D_e"}, {"name": "L-Methionine", "notes": {"original_bigg_ids": ["met_L_e"]}, "charge": 0, "formula": "C5H11NO2S", "compartment": "e", "id": "met__L_e"}, {"name": "L-methionine-R-sulfoxide", "notes": {"original_bigg_ids": ["metsox_R_L_e"]}, "charge": 0, "formula": "C5H11NO3S", "compartment": "e", "id": "metsox_R__L_e"}, {"name": "L-Methionine Sulfoxide", "notes": {"original_bigg_ids": ["metsox_S_L_e"]}, "charge": 0, "formula": "C5H11NO3S", "compartment": "e", "id": "metsox_S__L_e"}, {"name": "Magnesium", "notes": {"original_bigg_ids": ["mg2_e"]}, "charge": 2, "formula": "Mg", "compartment": "e", "id": "mg2_e"}, {"name": "Myo-Inositol hexakisphosphate", "notes": {"original_bigg_ids": ["minohp_e"]}, "charge": -12, "formula": "C6H6O24P6", "compartment": "e", "id": "minohp_e"}, {"name": "S-Methyl-L-methionine", "notes": {"original_bigg_ids": ["mmet_e"]}, "charge": 1, "formula": "C6H14NO2S", "compartment": "e", "id": "mmet_e"}, {"name": "Mn2+", "notes": {"original_bigg_ids": ["mn2_e"]}, "charge": 2, "formula": "Mn", "compartment": "e", "id": "mn2_e"}, {"name": "D-Mannitol", "notes": 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"id": "peamn_e"}, {"name": "L-Phenylalanine", "notes": {"original_bigg_ids": ["phe_L_e"]}, "charge": 0, "formula": "C9H11NO2", "compartment": "e", "id": "phe__L_e"}, {"name": "Protoheme", "notes": {"original_bigg_ids": ["pheme_e"]}, "charge": -2, "formula": "C34H30FeN4O4", "compartment": "e", "id": "pheme_e"}, {"name": "Phosphate", "notes": {"original_bigg_ids": ["pi_e"]}, "charge": -2, "formula": "HO4P", "compartment": "e", "id": "pi_e"}, {"name": "(R)-Pantothenate", "notes": {"original_bigg_ids": ["pnto_R_e"]}, "charge": -1, "formula": "C9H16NO5", "compartment": "e", "id": "pnto__R_e"}, {"name": "Propionate (n-C3:0)", "notes": {"original_bigg_ids": ["ppa_e"]}, "charge": -1, "formula": "C3H5O2", "compartment": "e", "id": "ppa_e"}, {"name": "Propanal", "notes": {"original_bigg_ids": ["ppal_e"]}, "charge": 0, "formula": "C3H6O", "compartment": "e", "id": "ppal_e"}, {"name": "Phenylpropanoate", "notes": {"original_bigg_ids": ["pppn_e"]}, "charge": -1, "formula": "C9H9O2", "compartment": 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{"name": "Acetoacetyl-CoA", "notes": {"original_bigg_ids": ["aacoa_c"]}, "charge": -4, "formula": "C25H36N7O18P3S", "compartment": "c", "id": "aacoa_c"}, {"name": "3-Oxohexanoyl-CoA", "notes": {"original_bigg_ids": ["3ohcoa_c"]}, "charge": -4, "formula": "C27H40N7O18P3S", "compartment": "c", "id": "3ohcoa_c"}, {"name": "3-Oxooctanoyl-CoA", "notes": {"original_bigg_ids": ["3oocoa_c"]}, "charge": -4, "formula": "C29H44N7O18P3S", "compartment": "c", "id": "3oocoa_c"}, {"name": "3-Oxodecanoyl-CoA", "notes": {"original_bigg_ids": ["3odcoa_c"]}, "charge": -4, "formula": "C31H48N7O18P3S", "compartment": "c", "id": "3odcoa_c"}, {"name": "3-Oxododecanoyl-CoA", "notes": {"original_bigg_ids": ["3oddcoa_c"]}, "charge": -4, "formula": "C33H52N7O18P3S", "compartment": "c", "id": "3oddcoa_c"}, {"name": "3-Oxotetradecanoyl-CoA", "notes": {"original_bigg_ids": ["3otdcoa_c"]}, "charge": -4, "formula": "C35H56N7O18P3S", "compartment": "c", "id": "3otdcoa_c"}, {"name": "3-Oxohexadecanoyl-CoA", "notes": {"original_bigg_ids": ["3ohdcoa_c"]}, "charge": -4, "formula": "C37H60N7O18P3S", "compartment": "c", "id": "3ohdcoa_c"}, {"name": "3-Oxooctadecanoyl-CoA", "notes": {"original_bigg_ids": ["3oodcoa_c"]}, "charge": -4, "formula": "C39H64N7O18P3S", "compartment": "c", "id": "3oodcoa_c"}, {"name": "3-Octaprenyl-4-hydroxybenzoate", "notes": {"original_bigg_ids": ["3ophb_c"]}, "charge": -1, "formula": "C47H69O3", "compartment": "c", "id": "3ophb_c"}, {"name": "3-hydroxycinnamic acid", "notes": {"original_bigg_ids": ["3hcinnm_p"]}, "charge": -1, "formula": "C9H7O3", "compartment": "p", "id": "3hcinnm_p"}, {"name": "Heme O", "notes": {"original_bigg_ids": ["hemeO_c"]}, "charge": -2, "formula": "C49H56FeN4O5", "compartment": "c", "id": "hemeO_c"}, {"name": "Heptosyl-heptosyl-kdo2-lipidA", "notes": {"original_bigg_ids": ["hhlipa_c"]}, "charge": -6, "formula": "C124H220N2O51P2", "compartment": "c", "id": "hhlipa_c"}, {"name": "Phospho-heptosyl-heptosyl-kdo2-lipidA", "notes": {"original_bigg_ids": ["phhlipa_c"]}, "charge": -8, "formula": "C124H219N2O54P3", "compartment": "c", "id": "phhlipa_c"}, {"name": "Heptosyl-phospho-heptosyl-heptosyl-kdo2-lipidA", "notes": {"original_bigg_ids": ["hphhlipa_c"]}, "charge": -8, "formula": "C131H231N2O60P3", "compartment": "c", "id": "hphhlipa_c"}, {"name": "Phospho-heptosyl-phospho-heptosyl-heptosyl-kdo2-lipidA", "notes": {"original_bigg_ids": ["phphhlipa_c"]}, "charge": -10, "formula": "C131H230N2O63P4", "compartment": "c", "id": "phphhlipa_c"}, {"name": "Heptosyl-kdo2-lipidA", "notes": {"original_bigg_ids": ["hlipa_c"]}, "charge": -6, "formula": "C117H208N2O45P2", "compartment": "c", "id": "hlipa_c"}, {"name": "4-Methyl-5-(2-hydroxyethyl)-thiazole", "notes": {"original_bigg_ids": ["4mhetz_c"]}, "charge": 0, "formula": "C6H9NOS", "compartment": "c", "id": "4mhetz_c"}, {"name": "4-Methyl-5-(2-phosphoethyl)-thiazole", "notes": {"original_bigg_ids": ["4mpetz_c"]}, "charge": -2, "formula": "C6H8NO4PS", "compartment": "c", "id": "4mpetz_c"}, {"name": "D-Mannose 6-phosphate", "notes": {"original_bigg_ids": ["man6p_c"]}, "charge": -2, "formula": "C6H11O9P", "compartment": "c", "id": "man6p_c"}, {"name": "Hg2+", "notes": {"original_bigg_ids": ["hg2_p"]}, "charge": 2, "formula": "Hg", "compartment": "p", "id": "hg2_p"}, {"name": "Hg2+", "notes": {"original_bigg_ids": ["hg2_c"]}, "charge": 2, "formula": "Hg", "compartment": "c", "id": "hg2_c"}, {"name": "L-Histidinol", "notes": {"original_bigg_ids": ["histd_c"]}, "charge": 1, "formula": "C6H12N3O", "compartment": "c", "id": "histd_c"}, {"name": "L-Histidinol phosphate", "notes": {"original_bigg_ids": ["hisp_c"]}, "charge": -1, "formula": "C6H11N3O4P", "compartment": "c", "id": "hisp_c"}, {"name": "L-Histidyl-tRNA(His)", "notes": {"original_bigg_ids": ["histrna_c"]}, "charge": 1, "formula": "C6H8N3OR", "compartment": "c", "id": "histrna_c"}, {"name": "TRNA(His)", "notes": {"original_bigg_ids": ["trnahis_c"]}, "charge": 0, "formula": "R", "compartment": "c", "id": "trnahis_c"}, {"name": "L-Histidine", "notes": {"original_bigg_ids": ["his_L_p"]}, "charge": 0, "formula": "C6H9N3O2", "compartment": "p", "id": "his__L_p"}, {"name": "Porphobilinogen", "notes": {"original_bigg_ids": ["ppbng_c"]}, "charge": -1, "formula": "C10H13N2O4", "compartment": "c", "id": "ppbng_c"}, {"name": "Hydroxymethylbilane", "notes": {"original_bigg_ids": ["hmbil_c"]}, "charge": -8, "formula": "C40H38N4O17", "compartment": "c", "id": "hmbil_c"}, {"name": "4-Amino-5-hydroxymethyl-2-methylpyrimidine", "notes": {"original_bigg_ids": ["4ahmmp_c"]}, "charge": 0, "formula": "C6H9N3O", "compartment": "c", "id": "4ahmmp_c"}, {"name": "3-(3-hydroxy-phenyl)propionate", "notes": {"original_bigg_ids": ["3hpppn_p"]}, "charge": -1, "formula": "C9H9O3", "compartment": "p", "id": "3hpppn_p"}, {"name": "Hydroxypyruvate", "notes": {"original_bigg_ids": ["hpyr_c"]}, "charge": -1, "formula": "C3H3O4", "compartment": "c", "id": "hpyr_c"}, {"name": "O-Phospho-L-homoserine", "notes": {"original_bigg_ids": ["phom_c"]}, "charge": -2, "formula": "C4H8NO6P", "compartment": "c", "id": "phom_c"}, {"name": "O-Succinyl-L-homoserine", "notes": {"original_bigg_ids": ["suchms_c"]}, "charge": -1, "formula": "C8H12NO6", "compartment": "c", "id": "suchms_c"}, {"name": "3-(Imidazol-4-yl)-2-oxopropyl phosphate", "notes": {"original_bigg_ids": ["imacp_c"]}, "charge": -2, "formula": "C6H7N2O5P", "compartment": "c", "id": "imacp_c"}, {"name": "Hypoxanthine", "notes": {"original_bigg_ids": ["hxan_c"]}, "charge": 0, "formula": "C5H4N4O", "compartment": "c", "id": "hxan_c"}, {"name": "Pyridoxamine", "notes": {"original_bigg_ids": ["pydam_c"]}, "charge": 1, "formula": "C8H13N2O2", "compartment": "c", "id": "pydam_c"}, {"name": "Hypoxanthine", "notes": {"original_bigg_ids": ["hxan_p"]}, "charge": 0, "formula": "C5H4N4O", "compartment": "p", "id": "hxan_p"}, {"name": "Isochorismate", "notes": {"original_bigg_ids": ["ichor_c"]}, "charge": -2, "formula": "C10H8O6", "compartment": "c", "id": "ichor_c"}, {"name": "L-Idonate", "notes": {"original_bigg_ids": ["idon_L_p"]}, "charge": -1, "formula": "C6H11O7", "compartment": "p", "id": "idon__L_p"}, {"name": "D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate", "notes": {"original_bigg_ids": ["eig3p_c"]}, "charge": -2, "formula": "C6H9N2O6P", "compartment": "c", "id": "eig3p_c"}, {"name": "5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide", "notes": {"original_bigg_ids": ["prlp_c"]}, "charge": -4, "formula": "C15H21N5O15P2", "compartment": "c", "id": "prlp_c"}, {"name": "C'-(3-Indolyl)-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["3ig3p_c"]}, "charge": -2, "formula": "C11H12NO6P", "compartment": "c", "id": "3ig3p_c"}, {"name": "1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate", "notes": {"original_bigg_ids": ["2cpr5p_c"]}, "charge": -3, "formula": "C12H13NO9P", "compartment": "c", "id": "2cpr5p_c"}, {"name": "L-Isoleucyl-tRNA(Ile)", "notes": {"original_bigg_ids": ["iletrna_c"]}, 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"C8H13O8", "compartment": "c", "id": "kdo_c"}, {"name": "CMP-3-deoxy-D-manno-octulosonate", "notes": {"original_bigg_ids": ["ckdo_c"]}, "charge": -2, "formula": "C17H24N3O15P", "compartment": "c", "id": "ckdo_c"}, {"name": "3-Deoxy-D-manno-octulosonate 8-phosphate", "notes": {"original_bigg_ids": ["kdo8p_c"]}, "charge": -3, "formula": "C8H12O11P", "compartment": "c", "id": "kdo8p_c"}, {"name": "L-Xylulose 5-phosphate", "notes": {"original_bigg_ids": ["xu5p_L_c"]}, "charge": -2, "formula": "C5H9O8P", "compartment": "c", "id": "xu5p__L_c"}, {"name": "Potassium", "notes": {"original_bigg_ids": ["k_p"]}, "charge": 1, "formula": "K", "compartment": "p", "id": "k_p"}, {"name": "Undecaprenyl phosphate-4-amino-4-deoxy-L-arabinose", "notes": {"original_bigg_ids": ["uLa4n_p"]}, "charge": 0, "formula": "C60H100N1O7P1", "compartment": "p", "id": "uLa4n_p"}, {"name": "Undecaprenyl phosphate", "notes": {"original_bigg_ids": ["udcpp_p"]}, "charge": -2, "formula": "C55H89O4P", "compartment": "p", "id": "udcpp_p"}, {"name": "D-Lactaldehyde", "notes": {"original_bigg_ids": ["lald_D_c"]}, "charge": 0, "formula": "C3H6O2", "compartment": "c", "id": "lald__D_c"}, {"name": "Lactose", "notes": {"original_bigg_ids": ["lcts_p"]}, "charge": 0, "formula": "C12H22O11", "compartment": "p", "id": "lcts_p"}, {"name": "4-Methyl-2-oxopentanoate", "notes": {"original_bigg_ids": ["4mop_c"]}, "charge": -1, "formula": "C6H9O3", "compartment": "c", "id": "4mop_c"}, {"name": "L-Leucyl-tRNA(Leu)", "notes": {"original_bigg_ids": ["leutrna_c"]}, "charge": 1, "formula": "C6H12NOR", "compartment": "c", "id": "leutrna_c"}, {"name": "TRNA(Leu)", "notes": {"original_bigg_ids": ["trnaleu_c"]}, "charge": 0, "formula": "R", "compartment": "c", "id": "trnaleu_c"}, {"name": "L-Leucine", "notes": {"original_bigg_ids": ["leu_L_p"]}, "charge": 0, "formula": "C6H13NO2", "compartment": "p", "id": "leu__L_p"}, {"name": "KDO(2)-lipid (A)", "notes": {"original_bigg_ids": ["lipa_p"]}, "charge": -6, "formula": 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"formula": "C511H850O330P2", "compartment": "p", "id": "udcdp19Oag_p"}, {"name": "CDP-glucose", "notes": {"original_bigg_ids": ["cdpglc_c"]}, "charge": -2, "formula": "C15H23N3O16P2", "compartment": "c", "id": "cdpglc_c"}, {"name": "CDP-4-dehydro-6-deoxy-D-glucose", "notes": {"original_bigg_ids": ["cdp4dh6doglc_c"]}, "charge": -2, "formula": "C15H21N3O15P2", "compartment": "c", "id": "cdp4dh6doglc_c"}, {"name": "CDP-4-dehydro-3-6-dideoxy-D-glucose", "notes": {"original_bigg_ids": ["cdp4dh36ddglc_c"]}, "charge": -2, "formula": "C15H21N3O14P2", "compartment": "c", "id": "cdp4dh36ddglc_c"}, {"name": "Salmochelin-S4", "notes": {"original_bigg_ids": ["salchs4_e"]}, "charge": 0, "formula": "C42H47N3O25", "compartment": "e", "id": "salchs4_e"}, {"name": "Salmochelin-S4-Fe-III", "notes": {"original_bigg_ids": ["salchs4fe_e"]}, "charge": 3, "formula": "C42FeH47N3O25", "compartment": "e", "id": "salchs4fe_e"}, {"name": "Salmochelin-S4-Fe-III", "notes": {"original_bigg_ids": ["salchs4fe_p"]}, 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