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"Acetaldehyde transport via diffusion (extracellular to periplasm)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ACALDtex"]}, "metabolites": {"acald_p": 1.0, "acald_e": -1.0}, "id": "ACALDtex", "gene_reaction_rule": "b2215 or b0241 or b1377 or b0929"}, {"subsystem": "Transport, Inner Membrane", "name": "Acetaldehyde reversible transport (periplasm)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ACALDtpp"]}, "metabolites": {"acald_c": 1.0, "acald_p": -1.0}, "id": "ACALDtpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Acetyl-CoA:anthranilate acetyltransferase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACANTHAT"]}, "metabolites": {"anth_c": -1.0, "coa_c": 1.0, "accoa_c": -1.0, "acanth_c": 1.0}, "id": "ACANTHAT", "gene_reaction_rule": "b1463"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Adenosyl cobinamide phosphate guanyltransferase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACBIPGT"]}, "metabolites": {"adocbip_c": -1.0, "ppi_c": 1.0, "gtp_c": -1.0, "h_c": -1.0, "agdpcbi_c": 1.0}, "id": "ACBIPGT", "gene_reaction_rule": "b1993"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA carboxylase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACCOAC"]}, "metabolites": {"malcoa_c": 1.0, "adp_c": 1.0, "atp_c": -1.0, "hco3_c": -1.0, "h_c": 1.0, "accoa_c": -1.0, "pi_c": 1.0}, "id": "ACCOAC", "gene_reaction_rule": "b0185 and b3255 and b3256 and b2316"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Acetate-CoA ligase (ADP-forming)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACCOAL"]}, "metabolites": {"adp_c": 1.0, "atp_c": -1.0, "ppa_c": -1.0, "coa_c": -1.0, "ppcoa_c": 1.0, "pi_c": 1.0}, "id": "ACCOAL", "gene_reaction_rule": "b0335"}, {"subsystem": "Alternate Carbon Metabolism", "name": "N-acetyl-D-galactosamine 1-phosphatase (periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGAL1PPpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "acgal_p": 1.0, "acgal1p_p": -1.0}, "id": "ACGAL1PPpp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "N-acetyl-D-galactosamine 1-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ACGAL1Ptex"]}, "metabolites": {"acgal1p_p": 1.0, "acgal1p_e": -1.0}, "id": "ACGAL1Ptex", "gene_reaction_rule": "b2215 or b0241 or b1377 or b0929"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "N-acetyl-D-galactosamine transport via diffusion (extracellular to periplasm)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ACGALtex"]}, "metabolites": {"acgal_p": 1.0, "acgal_e": -1.0}, "id": "ACGALtex", 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"b2215 or b0241 or b1377 or b0929"}, {"subsystem": "Murein Recycling", "name": "L-alanyl-gamma-glutamate epimerase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ALAGLUE"]}, "metabolites": {"LalaDglu_c": -1.0, "LalaLglu_c": 1.0}, "id": "ALAGLUE", "gene_reaction_rule": "b1325"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "Alanine racemase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ALAR"]}, "metabolites": {"ala__L_c": -1.0, "ala__D_c": 1.0}, "id": "ALAR", "gene_reaction_rule": "b4053 or b1190"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "D-alanine transaminase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALATA_D2"]}, "metabolites": {"ala__D_c": -1.0, "pyr_c": 1.0, "pydx5p_c": -1.0, "pyam5p_c": 1.0}, "id": "ALATA_D2", "gene_reaction_rule": "b2551 or b0870"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "L-alanine 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0.0, "notes": {"original_bigg_ids": ["DCYTD"]}, "metabolites": {"dcyt_c": -1.0, "h2o_c": -1.0, "nh4_c": 1.0, "duri_c": 1.0, "h_c": -1.0}, "id": "DCYTD", "gene_reaction_rule": "b2143"}, {"subsystem": "Transport, Inner Membrane", "name": "Deoxycytidine transport in via proton symport (periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DCYTt2pp"]}, "metabolites": {"dcyt_c": 1.0, "dcyt_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "DCYTt2pp", "gene_reaction_rule": "b2964 or b2393"}, {"subsystem": "Transport, Outer Membrane", "name": "Deoxycytidine transport via diffusion (extracellular to periplasm)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["DCYTtex"]}, "metabolites": {"dcyt_p": 1.0, "dcyt_e": -1.0}, "id": "DCYTtex", "gene_reaction_rule": "b0411"}, {"subsystem": "Transport, Outer Membrane", "name": "Fatty acid (dodecanoate) transport via facilitated irreversible diffusion (extracellular to periplasm)", 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{"subsystem": "Oxidative Phosphorylation", "name": "Dimethyl sulfoxide reductase (Menaquinol 8)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DMSOR1"]}, "metabolites": {"dms_c": 1.0, "h2o_c": 1.0, "dmso_c": -1.0, "mqn8_c": 1.0, "mql8_c": -1.0}, "id": "DMSOR1", "gene_reaction_rule": "(b0894 and b0896 and b0895) or (b1589 and b1587 and b1590 and b1588)"}, {"subsystem": "Oxidative Phosphorylation", "name": "Dimethyl sulfoxide reductase (Menaquinol 8) (periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DMSOR1pp"]}, "metabolites": {"dmso_p": -1.0, "h2o_p": 1.0, "dms_p": 1.0, "mqn8_c": 1.0, "mql8_c": -1.0}, "id": "DMSOR1pp", "gene_reaction_rule": "b1873 and b1872"}, {"subsystem": "Oxidative Phosphorylation", "name": "Dimethyl sulfoxide reductase (Demethylmenaquinol 8)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DMSOR2"]}, "metabolites": {"h2o_c": 1.0, "dmso_c": -1.0, "dms_c": 1.0, 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"UTP-glucose-1-phosphate uridylyltransferase (irreversible)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALUi"]}, "metabolites": {"utp_c": -1.0, "ppi_c": 1.0, "udpg_c": 1.0, "h_c": -1.0, "g1p_c": -1.0}, "id": "GALUi", "gene_reaction_rule": "b1236"}, {"subsystem": "Transport, Inner Membrane", "name": "D-galactose transport via ABC system (periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "gal_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "gal_p": -1.0, "pi_c": 1.0}, "id": "GALabcpp", "gene_reaction_rule": "b2148 and b2150 and b2149"}, {"subsystem": "Transport, Inner Membrane", "name": "D-galactose transport in via proton symport (periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALt2pp"]}, "metabolites": {"gal_p": -1.0, "gal_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GALt2pp", "gene_reaction_rule": "b2943"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-galactose transport via diffusion (extracellular to periplasm)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GALtex"]}, "metabolites": {"gal_p": 1.0, "gal_e": -1.0}, "id": "GALtex", "gene_reaction_rule": "b2215 or b0241 or b1377 or b0929"}, {"subsystem": "Transport, Inner Membrane", "name": "D-Glucosamine 6-phosphate transport via phosphate antiport (periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GAM6Pt6_2pp"]}, "metabolites": {"pi_p": 2.0, "gam6p_p": -1.0, "gam6p_c": 1.0, "pi_c": -2.0}, "id": "GAM6Pt6_2pp", "gene_reaction_rule": "b3666"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-glucosamine 6-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["GAMAN6Ptex"]}, "metabolites": {"gam6p_p": 1.0, "gam6p_e": -1.0}, "id": "GAMAN6Ptex", 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"ILEtex", "gene_reaction_rule": "b2215 or b0241 or b1377 or b0929"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "IMP cyclohydrolase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["IMPC"]}, "metabolites": {"h2o_c": -1.0, "fprica_c": 1.0, "imp_c": -1.0}, "id": "IMPC", "gene_reaction_rule": "b4006"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "IMP dehydrogenase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IMPD"]}, "metabolites": {"xmp_c": 1.0, "h2o_c": -1.0, "h_c": 1.0, "nad_c": -1.0, "nadh_c": 1.0, "imp_c": -1.0}, "id": "IMPD", "gene_reaction_rule": "b2508"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "IMP transport via diffusion (extracellular to periplasm)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["IMPtex"]}, "metabolites": {"imp_e": -1.0, "imp_p": 1.0}, "id": "IMPtex", "gene_reaction_rule": "b2215 or b0241 or b1377 or b0929"}, {"subsystem": "Transport, Inner Membrane", "name": "Indole transport via proton symport, irreversible (periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["INDOLEt2pp"]}, "metabolites": {"indole_p": 1.0, "indole_c": -1.0, "h_p": 1.0, "h_c": -1.0}, "id": "INDOLEt2pp", "gene_reaction_rule": "b3265 and b3266"}, {"subsystem": "Transport, Inner Membrane", "name": "Indole transport via proton symport, reversible (periplasm)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["INDOLEt2rpp"]}, "metabolites": {"indole_p": -1.0, "indole_c": 1.0, "h_p": -1.0, "h_c": 1.0}, "id": "INDOLEt2rpp", "gene_reaction_rule": "b3161"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Indole transport via diffusion (extracellular to periplasm)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["INDOLEtex"]}, "metabolites": {"indole_e": -1.0, "indole_p": 1.0}, "id": "INDOLEtex", "gene_reaction_rule": "b2215 or b0241 or b1377 or b0929"}, {"subsystem": "Transport, Inner Membrane", "name": "Na+/myo-inositol symporter (periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["INOSTt4pp"]}, "metabolites": {"na1_p": -1.0, "na1_c": 1.0, "inost_c": 1.0, "inost_p": -1.0}, "id": "INOSTt4pp", "gene_reaction_rule": "b3679"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Inosine hydrolase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["INSH"]}, "metabolites": {"rib__D_c": 1.0, "h2o_c": -1.0, "hxan_c": 1.0, "ins_c": -1.0}, "id": "INSH", "gene_reaction_rule": "b0030"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Insosine kinase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["INSK"]}, "metabolites": {"h_c": 1.0, "ins_c": -1.0, "imp_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "INSK", "gene_reaction_rule": "b0477"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Inositol transport via diffusion (extracellular to periplasm)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["INSTtex"]}, "metabolites": {"inost_e": -1.0, "inost_p": 1.0}, "id": "INSTtex", "gene_reaction_rule": "b2215 or b0241 or b1377 or b0929"}, {"subsystem": "Transport, Inner Membrane", "name": "Inosine transport in via proton symport (periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["INSt2pp", "INSt2rpp"]}, "metabolites": {"ins_p": -1.0, "h_c": 1.0, "h_p": -1.0, "ins_c": 1.0}, "id": "INSt2pp_copy1", "gene_reaction_rule": "b2964"}, {"subsystem": "Transport, Inner Membrane", "name": "Inosine transport in via proton symport (periplasm)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["INSt2pp", "INSt2rpp"]}, "metabolites": {"ins_p": -1.0, "h_c": 1.0, "h_p": -1.0, "ins_c": 1.0}, "id": "INSt2pp_copy2", "gene_reaction_rule": "b2406"}, {"subsystem": "Transport, Outer Membrane", "name": "Inosine transport via diffusion (extracellular to periplasm)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["INStex"]}, "metabolites": {"ins_e": -1.0, "ins_p": 1.0}, "id": "INStex", "gene_reaction_rule": "b0411"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Isopentenyl-diphosphate D-isomerase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["IPDDI"]}, "metabolites": {"dmpp_c": 1.0, "ipdp_c": -1.0}, "id": "IPDDI", "gene_reaction_rule": "b2889"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (ipdp)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IPDPS"]}, "metabolites": {"h2o_c": 1.0, "ipdp_c": 1.0, "h2mb4p_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "nadh_c": -1.0}, "id": "IPDPS", "gene_reaction_rule": "b0029"}, {"subsystem": "Valine, Leucine, and Isoleucine 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"2-isopropylmalate synthase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IPPS"]}, "metabolites": {"h2o_c": -1.0, "3c3hmp_c": 1.0, "3mob_c": -1.0, "coa_c": 1.0, "h_c": 1.0, "accoa_c": -1.0}, "id": "IPPS", "gene_reaction_rule": "b0074"}, {"subsystem": "Transport, Inner Membrane", "name": "Isethionate transport via ABC system (periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ISETACabcpp"]}, "metabolites": {"isetac_c": 1.0, "h2o_c": -1.0, "atp_c": -1.0, "isetac_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "ISETACabcpp", "gene_reaction_rule": "(b0367 and b0365 and b0366) or (b0933 and b0934 and b0936)"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Isethionate transport via diffusion (extracellular to periplasm)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ISETACtex"]}, "metabolites": {"isetac_p": 1.0, "isetac_e": -1.0}, "id": "ISETACtex", "gene_reaction_rule": "b2215 or b0241 or b1377 or b0929"}, {"subsystem": "Transport, Inner Membrane", "name": "KDO(2)-lipid IV A transport via ABC system (periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["K2L4Aabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "kdo2lipid4_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "kdo2lipid4_c": -1.0, "pi_c": 1.0}, "id": "K2L4Aabcpp", "gene_reaction_rule": "b0914"}, {"subsystem": "Transport, Outer Membrane", "name": "KDO(2)-lipid IV A transport via vector (periplasm to extracellular)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["K2L4Atex"]}, "metabolites": {"kdo2lipid4_p": -1.0, "kdo2lipid4_e": 1.0}, "id": "K2L4Atex", "gene_reaction_rule": ""}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Ketol-acid reductoisomerase (2,3-dihydroxy-3-methylbutanoate)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["KARA1"]}, "metabolites": {"nadp_c": -1.0, "nadph_c": 1.0, "h_c": 1.0, "23dhmb_c": -1.0, "alac__S_c": 1.0}, "id": "KARA1", "gene_reaction_rule": "b3774"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Ketol-acid reductoisomerase (2-Acetolactate)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["KARA2"]}, "metabolites": {"23dhmp_c": 1.0, "2ahbut_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0}, "id": "KARA2", "gene_reaction_rule": "b3774"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Beta-ketoacyl-ACP synthase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KAS14"]}, "metabolites": {"acACP_c": -1.0, "ACP_c": 1.0, "malACP_c": -1.0, "h_c": -1.0, "actACP_c": 1.0, "co2_c": 1.0}, "id": "KAS14", "gene_reaction_rule": "b2323 or b1095"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Beta-ketoacyl-ACP synthase (2)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KAS15"]}, "metabolites": {"malACP_c": -1.0, "coa_c": 1.0, "h_c": -1.0, "accoa_c": -1.0, "actACP_c": 1.0, "co2_c": 1.0}, "id": "KAS15", "gene_reaction_rule": "b1091"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-ketoacyl-CoA thiolase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KAT1"]}, "metabolites": {"aacoa_c": -1.0, "coa_c": -1.0, "accoa_c": 2.0}, "id": "KAT1", "gene_reaction_rule": "b3845 or b2342"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-ketoacyl-CoA thiolase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KAT2"]}, "metabolites": {"btcoa_c": 1.0, "coa_c": -1.0, "accoa_c": 1.0, "3ohcoa_c": -1.0}, "id": "KAT2", "gene_reaction_rule": "b2342 or b3845"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-ketoacyl-CoA thiolase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KAT3"]}, "metabolites": {"coa_c": -1.0, "3oocoa_c": -1.0, "hxcoa_c": 1.0, "accoa_c": 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"Alternate Carbon Metabolism", "name": "Maltose O-acetyltransferase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["MALTATr"]}, "metabolites": {"acmalt_c": 1.0, "malt_c": -1.0, "coa_c": 1.0, "accoa_c": -1.0}, "id": "MALTATr", "gene_reaction_rule": "b0459"}, {"subsystem": "Transport, Inner Membrane", "name": "Maltohexaose transport via ABC system (periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTHXabcpp"]}, "metabolites": {"h2o_c": -1.0, "malthx_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "malthx_p": -1.0, "pi_c": 1.0}, "id": "MALTHXabcpp", "gene_reaction_rule": "b4035 and b4032 and b4033 and b4034"}, {"subsystem": "Transport, Outer Membrane", "name": "Maltohexaose transport via diffusion (extracellular to periplasm) irreversible", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTHXtexi"]}, "metabolites": {"malthx_e": -1.0, "malthx_p": 1.0}, "id": "MALTHXtexi", 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{"glc__D_c": 1.0, "malthx_c": 1.0, "h2o_c": -1.0, "malthp_c": -1.0}, "id": "MLTG5", "gene_reaction_rule": "b0403"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein4p4p) (periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY1pp"]}, "metabolites": {"murein4p4p_p": -1.0, "anhgm4p_p": 2.0}, "id": "MLTGY1pp", "gene_reaction_rule": "b2701 or b2963 or b2813 or b4392 or b1193"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein4p3p) (periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY2pp"]}, "metabolites": {"murein4p3p_p": -1.0, "anhgm3p_p": 1.0, "anhgm4p_p": 1.0}, "id": "MLTGY2pp", "gene_reaction_rule": "b2701 or b2963 or b2813 or b4392 or b1193"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein3p3p) (periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY3pp"]}, "metabolites": {"murein3p3p_p": -1.0, "anhgm3p_p": 2.0}, "id": "MLTGY3pp", "gene_reaction_rule": "b2701 or b2963 or b2813 or b4392 or b1193"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein4px4p4p) (periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY4pp"]}, "metabolites": {"murein4px4p_p": 1.0, "murein4px4p4p_p": -1.0, "anhgm4p_p": 1.0}, "id": "MLTGY4pp", "gene_reaction_rule": "b2813 or b1193 or b4392 or b2963 or b2701"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin phosphorylase (maltopentaose)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["MLTP1"]}, "metabolites": {"maltpt_c": -1.0, "pi_c": -1.0, "g1p_c": 1.0, "maltttr_c": 1.0}, "id": "MLTP1", "gene_reaction_rule": "b3417"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin phosphorylase (maltohexaose)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["MLTP2"]}, "metabolites": {"maltpt_c": 1.0, "pi_c": -1.0, "malthx_c": -1.0, "g1p_c": 1.0}, "id": "MLTP2", "gene_reaction_rule": "b3417"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin phosphorylase (maltoheptaose)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["MLTP3"]}, "metabolites": {"malthp_c": -1.0, "pi_c": -1.0, "malthx_c": 1.0, "g1p_c": 1.0}, "id": "MLTP3", "gene_reaction_rule": "b3417"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Methylmalonyl-CoA decarboxylase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MMCD"]}, "metabolites": {"mmcoa__S_c": -1.0, "co2_c": 1.0, "h_c": -1.0, "ppcoa_c": 1.0}, "id": "MMCD", "gene_reaction_rule": "b2919"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Methylmalonyl-CoA epimerase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["MME"]}, "metabolites": {"mmcoa__S_c": 1.0, "mmcoa__R_c": -1.0}, "id": "MME", "gene_reaction_rule": ""}, {"subsystem": "Transport, Inner Membrane", "name": "S-methylmethionine permease (periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MMETt2pp"]}, "metabolites": {"mmet_p": -1.0, "mmet_c": 1.0, "h_p": -1.0, "h_c": 1.0}, "id": "MMETt2pp", "gene_reaction_rule": "b0260"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "S-methyl-L-methionine transport via diffusion (extracellular to periplasm)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["MMETtex"]}, "metabolites": {"mmet_e": -1.0, "mmet_p": 1.0}, "id": "MMETtex", "gene_reaction_rule": "b2215 or b0241 or b1377 or b0929"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Methylmalonyl-CoA mutase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MMM2"]}, "metabolites": {"mmcoa__R_c": 1.0, "succoa_c": -1.0}, "id": "MMM2", "gene_reaction_rule": "b2917"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Manganese (Mn+2) transport out via proton antiport (periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MN2t3pp"]}, "metabolites": {"mn2_p": 1.0, "mn2_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "MN2t3pp", "gene_reaction_rule": "b3915 or b0752"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Manganese transport in via permease (no H+)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MN2tpp"]}, "metabolites": {"mn2_p": -1.0, "mn2_c": 1.0}, "id": "MN2tpp", "gene_reaction_rule": "b3040"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Mannose 6-phosphate phosphatase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MN6PP"]}, "metabolites": {"h2o_c": -1.0, "man6p_c": -1.0, "pi_c": 1.0, "man_c": 1.0}, "id": "MN6PP", "gene_reaction_rule": "b0822"}, {"subsystem": "Transport, Inner Membrane", "name": "Mannitol transport via PEP:Pyr PTS (periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MNLptspp"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "mnl_p": -1.0, "mnl1p_c": 1.0}, "id": "MNLptspp", "gene_reaction_rule": "b2415 and b2416 and b3599"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Mannitol transport via diffusion (extracellular to periplasm)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["MNLtex"]}, "metabolites": {"mnl_p": 1.0, "mnl_e": -1.0}, "id": "MNLtex", "gene_reaction_rule": "b0929 or b1377 or b0241 or b2215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "D-mannonate hydrolyase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MNNH"]}, "metabolites": {"h2o_c": 1.0, "2ddglcn_c": 1.0, "mana_c": -1.0}, "id": "MNNH", "gene_reaction_rule": "b4322"}, {"subsystem": "Transport, Inner Membrane", "name": "Manganese (Mn+2) transport in via proton symport (periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MNt2pp"]}, "metabolites": {"mn2_p": -1.0, "mn2_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "MNt2pp", "gene_reaction_rule": "b2392"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Manganese (Mn+2) transport via diffusion (extracellular to periplasm)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["MNtex"]}, "metabolites": {"mn2_p": 1.0, "mn2_e": -1.0}, "id": "MNtex", "gene_reaction_rule": "b2215 or b0241 or b1377 or b0929"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "3-deoxy-D-manno-octulosonic acid transferase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOAT"]}, "metabolites": {"h_c": 1.0, "ckdo_c": -1.0, "lipidA_c": -1.0, "kdolipid4_c": 1.0, "cmp_c": 1.0}, "id": "MOAT", "gene_reaction_rule": "b3633"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "3-deoxy-D-manno-octulosonic acid transferase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOAT2"]}, "metabolites": {"kdo2lipid4_c": 1.0, "ckdo_c": -1.0, "cmp_c": 1.0, "h_c": 1.0, "kdolipid4_c": -1.0}, "id": "MOAT2", "gene_reaction_rule": "b3633"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "3-deoxy-D-manno-octulosonic acid transferase III (LPS core biosynthesis)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOAT3C"]}, "metabolites": {"ckdo_c": -1.0, "cmp_c": 1.0, "h_c": 1.0, "phphhlipa_c": -1.0, "kphphhlipa_c": 1.0}, "id": "MOAT3C", "gene_reaction_rule": "b3624"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Molybdate transport via ABC system (periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOBDabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "mobd_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "mobd_p": -1.0}, "id": "MOBDabcpp", "gene_reaction_rule": "(b2422 and b2425 and b2423 and b2424) or (b2422 and b2423 and b3917 and b2424) or (b0764 and b0763 and b0765)"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Molybdate transport via diffusion (extracellular to periplasm)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["MOBDtex"]}, "metabolites": {"mobd_e": -1.0, "mobd_p": 1.0}, "id": "MOBDtex", "gene_reaction_rule": "b2215 or b0241 or b1377 or b0929"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "3-methyl-2-oxobutanoate hydroxymethyltransferase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOHMT"]}, "metabolites": {"thf_c": 1.0, "h2o_c": -1.0, "mlthf_c": -1.0, "2dhp_c": 1.0, "3mob_c": -1.0}, "id": "MOHMT", "gene_reaction_rule": "b0134"}, {"subsystem": "Murein Biosynthesis", "name": "Murein polymerizing transglycosylase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MPTG"]}, "metabolites": {"udcpdp_c": 2.0, "uaagmda_c": -2.0, "h_c": 2.0, "murein5p5p_p": 1.0}, "id": "MPTG", "gene_reaction_rule": "b0149 or b2519 or b3396"}, {"subsystem": "Murein Biosynthesis", "name": "Murein polymerizing transglycosylase 2 (three linked units)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MPTG2"]}, "metabolites": {"udcpdp_c": 1.0, "murein5p5p5p_p": 1.0, "murein5p5p_p": -1.0, "h_c": 1.0, "uaagmda_c": -1.0}, "id": "MPTG2", "gene_reaction_rule": "b0149 or b3396 or b2519"}, {"subsystem": "Transport, Inner Membrane", "name": "Methanesulfonate transport via ABC system (periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MSO3abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "mso3_c": 1.0, "mso3_p": -1.0, "adp_c": 1.0, "pi_c": 1.0, "h_c": 1.0}, "id": "MSO3abcpp", "gene_reaction_rule": "b0933 and b0934 and b0936"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Methanesulfonate transport via diffusion (extracellular to periplasm)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["MSO3tex"]}, "metabolites": {"mso3_e": -1.0, "mso3_p": 1.0}, "id": "MSO3tex", "gene_reaction_rule": "b2215 or b0241 or b1377 or b0929"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Methylthioadenosine nucleosidase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MTAN"]}, "metabolites": {"ade_c": 1.0, "5mta_c": -1.0, "5mtr_c": 1.0, "h2o_c": -1.0}, "id": "MTAN", "gene_reaction_rule": "b0159"}, {"subsystem": "Folate Metabolism", "name": "Methenyltetrahydrofolate cyclohydrolase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["MTHFC"]}, "metabolites": {"h2o_c": -1.0, "10fthf_c": 1.0, "methf_c": -1.0, "h_c": 1.0}, "id": "MTHFC", "gene_reaction_rule": "b0529"}, {"subsystem": "Folate Metabolism", "name": "Methylenetetrahydrofolate dehydrogenase (NADP)", 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-1.0}, "id": "NACtpp", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NAD diphosphatase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADDP"]}, "metabolites": {"h2o_c": -1.0, "nmn_c": 1.0, "amp_c": 1.0, "nad_c": -1.0, "h_c": 2.0}, "id": "NADDP", "gene_reaction_rule": "b3996 or b2411"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (menaquinone-8 & 0 protons)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH10"]}, "metabolites": {"mql8_c": 1.0, "nadh_c": -1.0, "mqn8_c": -1.0, "h_c": -1.0, "nad_c": 1.0}, "id": "NADH10", "gene_reaction_rule": "b1109"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (ubiquinone-8 & 3 protons) (periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH16pp"]}, "metabolites": {"h_p": 3.0, "q8h2_c": 1.0, "h_c": -4.0, "nad_c": 1.0, "nadh_c": -1.0, "q8_c": 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-1.0, "nadp_c": 1.0, "adp_c": 1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "NADK", "gene_reaction_rule": "b2615"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NAD nucleosidase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADN"]}, "metabolites": {"h_c": 1.0, "h2o_c": -1.0, "adprib_c": 1.0, "nad_c": -1.0, "ncam_c": 1.0}, "id": "NADN", "gene_reaction_rule": ""}, {"subsystem": "Oxidative Phosphorylation", "name": "NADPH Quinone Reductase (Ubiquinone-8)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPHQR2"]}, "metabolites": {"q8h2_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "q8_c": -1.0, "h_c": -1.0}, "id": "NADPHQR2", "gene_reaction_rule": "b3028"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADPH Quinone Reductase (Menaquinone-8)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPHQR3"]}, "metabolites": {"mqn8_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "mql8_c": 1.0}, "id": "NADPHQR3", "gene_reaction_rule": "b3028"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADPH Quinone Reductase (2-Demethylmenaquinone-8)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPHQR4"]}, "metabolites": {"nadp_c": 1.0, "nadph_c": -1.0, "2dmmq8_c": -1.0, "2dmmql8_c": 1.0, "h_c": -1.0}, "id": "NADPHQR4", "gene_reaction_rule": "b3028"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NADP phosphatase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPPPS"]}, "metabolites": {"h2o_c": -1.0, "nadp_c": -1.0, "pi_c": 1.0, "nad_c": 1.0}, "id": "NADPPPS", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NAD synthase (nh3)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADS1"]}, "metabolites": {"dnad_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "nad_c": 1.0, "nh4_c": -1.0, "h_c": 1.0}, "id": "NADS1", "gene_reaction_rule": "b1740"}, {"subsystem": "Oxidative Phosphorylation", "name": "NAD transhydrogenase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADTRHD"]}, "metabolites": {"nadph_c": -1.0, "nadh_c": 1.0, "nadp_c": 1.0, "nad_c": -1.0}, "id": "NADTRHD", "gene_reaction_rule": "(b1602 and b1603) or b3962"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Nicotinic acid mononucleotide pyrophosphorylase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAMNPP"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "nicrnt_c": 1.0, "ppi_c": 1.0, "nac_c": -1.0, "adp_c": 1.0, "pi_c": 1.0, "prpp_c": -1.0}, "id": "NAMNPP", "gene_reaction_rule": "b0931"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Sodium proton antiporter (H:NA is 1.5) (periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAt3_1p5pp"]}, "metabolites": {"na1_p": 2.0, "na1_c": -2.0, "h_c": 3.0, "h_p": -3.0}, "id": "NAt3_1p5pp", "gene_reaction_rule": "b1186"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Sodium proton antiporter (H:NA is 2) (periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAt3_2pp"]}, "metabolites": {"na1_p": 1.0, "na1_c": -1.0, "h_c": 2.0, "h_p": -2.0}, "id": "NAt3_2pp", "gene_reaction_rule": "b0019"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Sodium transport out via proton antiport (cytoplasm to periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAt3pp"]}, "metabolites": {"na1_p": 1.0, "na1_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "NAt3pp", "gene_reaction_rule": "b0842 or b1216"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Sodium transport via diffusion (extracellular to periplasm)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NAtex"]}, "metabolites": 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"atp_c": -1.0}, "id": "NDPK3", "gene_reaction_rule": "b0474 or b2518"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:dTDP)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NDPK4"]}, "metabolites": {"dttp_c": 1.0, "dtdp_c": -1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "NDPK4", "gene_reaction_rule": "b2518 or b0474"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:dGDP)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NDPK5"]}, "metabolites": {"dgdp_c": -1.0, "dgtp_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "NDPK5", "gene_reaction_rule": "b2518 or b0474"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:dUDP)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NDPK6"]}, "metabolites": {"dutp_c": 1.0, "dudp_c": -1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "NDPK6", "gene_reaction_rule": "b2518 or b0474"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:dCDP)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NDPK7"]}, "metabolites": {"dcdp_c": -1.0, "atp_c": -1.0, "adp_c": 1.0, "dctp_c": 1.0}, "id": "NDPK7", "gene_reaction_rule": "b2518 or b0474"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:dADP)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NDPK8"]}, "metabolites": {"datp_c": 1.0, "adp_c": 1.0, "atp_c": -1.0, "dadp_c": -1.0}, "id": "NDPK8", "gene_reaction_rule": "b2518 or b0474"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Ammonia transport via diffusion (extracellular to periplasm)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NH4tex"]}, "metabolites": {"nh4_e": -1.0, "nh4_p": 1.0}, "id": "NH4tex", "gene_reaction_rule": "b2215 or 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"b3816"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Nickel transport via ABC system (uptake, periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NI2uabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "ni2_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "ni2_p": -1.0}, "id": "NI2uabcpp", "gene_reaction_rule": "b4242 or (b3479 and b3476 and b3478 and b3477 and b3480)"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Nicotinamide-nucleotide adenylyltransferase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NMNAT"]}, "metabolites": {"ppi_c": 1.0, "nmn_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "atp_c": -1.0}, "id": "NMNAT", "gene_reaction_rule": "b4390 or b0639"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Nicotinamide-nucleotide amidase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NMNDA"]}, "metabolites": 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{"subsystem": "Transport, Outer Membrane Porin", "name": "NMN transport via diffusion (extracellular to periplasm)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NMNtex"]}, "metabolites": {"nmn_e": -1.0, "nmn_p": 1.0}, "id": "NMNtex", "gene_reaction_rule": "b2215 or b0241 or b1377 or b0929"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Nicotinamidase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NNAM"]}, "metabolites": {"h2o_c": -1.0, "ncam_c": -1.0, "nh4_c": 1.0, "nac_c": 1.0}, "id": "NNAM", "gene_reaction_rule": "b1768"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nicotinate-nucleotide adenylyltransferase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["NNATr"]}, "metabolites": {"nicrnt_c": -1.0, "dnad_c": 1.0, "ppi_c": 1.0, "h_c": -1.0, "atp_c": -1.0}, "id": "NNATr", "gene_reaction_rule": "b0639"}, {"subsystem": "Cofactor and Prosthetic 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"Lipopolysaccharide Biosynthesis / Recycling", "name": "O16 antigen polymerase (periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["O16AP2pp"]}, "metabolites": {"h_p": 1.0, "o16a3und_p": 1.0, "udcpdp_p": 1.0, "o16a2und_p": -1.0, "o16aund_p": -1.0}, "id": "O16AP2pp", "gene_reaction_rule": "b2027 and b2035"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "O16 antigen polymerase (periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["O16AP3pp"]}, "metabolites": {"o16a3und_p": -1.0, "udcpdp_p": 1.0, "o16aund_p": -1.0, "h_p": 1.0, "o16a4und_p": 1.0}, "id": "O16AP3pp", "gene_reaction_rule": "b2027 and b2035"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Rhamanosyl-N-acetylglucosamyl-undecaprenyl diphosphate O-acetyltransferase (LPS O16 antigen biosynthesis)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["O16AT"]}, "metabolites": {"aragund_c": 1.0, "coa_c": 1.0, "accoa_c": -1.0, "ragund_c": -1.0}, "id": "O16AT", "gene_reaction_rule": "b2033"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "O16 antigen (flippase, cytoplasm to periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["O16AUNDtpp"]}, "metabolites": {"o16aund_c": -1.0, "o16aund_p": 1.0}, "id": "O16AUNDtpp", "gene_reaction_rule": "b2037"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Galactofuranosyltransferase (LPS O16 antigen biosynthesis)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["O16GALFT"]}, "metabolites": {"gfgaragund_c": 1.0, "garagund_c": -1.0, "udp_c": 1.0, "udpgalfur_c": -1.0, "h_c": 1.0}, "id": "O16GALFT", "gene_reaction_rule": "b2034"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Glucosyltransferase I (LPS O16 antigen biosynthesis)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": 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periplasm)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["O2tex"]}, "metabolites": {"o2_p": 1.0, "o2_e": -1.0}, "id": "O2tex", "gene_reaction_rule": "b2215 or b0241 or b1377 or b0929"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "O2 transport via diffusion (periplasm)", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["O2tpp"]}, "metabolites": {"o2_c": 1.0, "o2_p": -1.0}, "id": "O2tpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Pyruvate Metabolism", "name": "Oxaloacetate decarboxylase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OAADC"]}, "metabolites": {"pyr_c": 1.0, "co2_c": 1.0, "h_c": -1.0, "oaa_c": -1.0}, "id": "OAADC", "gene_reaction_rule": "b1850"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-Oxobutanoate formate lyase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OBTFL"]}, "metabolites": {"2obut_c": -1.0, "coa_c": -1.0, "ppcoa_c": 1.0, "for_c": 1.0}, "id": "OBTFL", "gene_reaction_rule": "(b2579 and (b0902 and b0903)) or (b0902 and b3114) or (b0902 and b0903)"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Ornithine carbamoyltransferase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["OCBT"]}, "metabolites": {"cbp_c": -1.0, "citr__L_c": 1.0, "orn_c": -1.0, "h_c": 1.0, "pi_c": 1.0}, "id": "OCBT", "gene_reaction_rule": "b4254 or b0273"}, {"subsystem": "Transport, Outer Membrane", "name": "Octadecanoate transport via facilitated irreversible diffusion (extracellular to periplasm)", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OCDCAtexi"]}, "metabolites": {"ocdca_e": -1.0, "ocdca_p": 1.0}, "id": "OCDCAtexi", "gene_reaction_rule": "b2344"}, {"subsystem": "Transport, Outer Membrane", "name": "Octadecenoate (n-C18:1) transport via facilitated irreversible diffusion (extracellular to periplasm)", 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0.0, "notes": {"original_bigg_ids": ["OMBZLM"]}, "metabolites": {"2ombzl_c": -1.0, "amet_c": -1.0, "ahcys_c": 1.0, "h_c": 1.0, "2ommbl_c": 1.0}, "id": "OMBZLM", "gene_reaction_rule": "b3833"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "2-Oxo-4-methyl-3-carboxypentanoate decarboxylation", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OMCDC"]}, "metabolites": {"3c4mop_c": -1.0, "co2_c": 1.0, "4mop_c": 1.0, "h_c": -1.0}, "id": "OMCDC", "gene_reaction_rule": "b0073"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OMMBLHX"]}, "metabolites": {"o2_c": -0.5, "2omhmbl_c": 1.0, "2ommbl_c": -1.0}, "id": "OMMBLHX", "gene_reaction_rule": "b0662"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase 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and Prosthetic Group Biosynthesis", "name": "Phosphopantothenoylcysteine decarboxylase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPCDC"]}, "metabolites": {"pan4p_c": 1.0, "co2_c": 1.0, "h_c": -1.0, "4ppcys_c": -1.0}, "id": "PPCDC", "gene_reaction_rule": "b3639"}, {"subsystem": "Anaplerotic Reactions", "name": "Phosphoenolpyruvate carboxykinase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPCK"]}, "metabolites": {"pep_c": 1.0, "co2_c": 1.0, "oaa_c": -1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "PPCK", "gene_reaction_rule": "b3403"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Propanoyl-CoA: succinate CoA-transferase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPCSCT"]}, "metabolites": {"succ_c": -1.0, "succoa_c": 1.0, "ppa_c": 1.0, "ppcoa_c": -1.0}, "id": "PPCSCT", "gene_reaction_rule": "b2920"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPGPPDP"]}, "metabolites": {"ppi_c": 1.0, "gdp_c": 1.0, "ppgpp_c": -1.0, "h2o_c": -1.0}, "id": "PPGPPDP", "gene_reaction_rule": "b3650"}, {"subsystem": "Oxidative Phosphorylation", "name": "Polyphosphate kinase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["PPK2r"]}, "metabolites": {"pppi_c": 1.0, "ppi_c": -1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "PPK2r", "gene_reaction_rule": "b2501"}, {"subsystem": "Oxidative Phosphorylation", "name": "Polyphosphate kinase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["PPKr"]}, "metabolites": {"ppi_c": 1.0, "pi_c": -1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "PPKr", "gene_reaction_rule": "b2501"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Phosphopentomutase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": 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"dxyl5p_c"}, {"name": "1-deoxy-D-xylulose", "notes": {"original_bigg_ids": ["dxyl_c"]}, "charge": 0, "formula": "C5H10O4", "compartment": "c", "id": "dxyl_c"}, {"name": "D-Erythrose 4-phosphate", "notes": {"original_bigg_ids": ["e4p_c"]}, "charge": -2, "formula": "C4H7O7P", "compartment": "c", "id": "e4p_c"}, {"name": "(enterobacterial common antigen)x2 undecaprenyl-diphosphate", "notes": {"original_bigg_ids": ["eca2und_p"]}, "charge": -4, "formula": "C103H162N6O37P2", "compartment": "p", "id": "eca2und_p"}, {"name": "(enterobacterial common antigen)x3 undecaprenyl-diphosphate", "notes": {"original_bigg_ids": ["eca3und_p"]}, "charge": -5, "formula": "C127H198N9O52P2", "compartment": "p", "id": "eca3und_p"}, {"name": "(enterobacterial common antigen)x4 core oligosaccharide lipid A", "notes": {"original_bigg_ids": ["eca4colipa_e"]}, "charge": -15, "formula": "C272H447N14O160P4", "compartment": "e", "id": "eca4colipa_e"}, {"name": "(enterobacterial common antigen)x4 core oligosaccharide 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"C2H5O3S", "compartment": "e", "id": "ethso3_e"}, {"name": "Ethanesulfonate", "notes": {"original_bigg_ids": ["ethso3_p"]}, "charge": -1, "formula": "C2H5O3S", "compartment": "p", "id": "ethso3_p"}, {"name": "Ethanol", "notes": {"original_bigg_ids": ["etoh_c"]}, "charge": 0, "formula": "C2H6O", "compartment": "c", "id": "etoh_c"}, {"name": "Ethanol", "notes": {"original_bigg_ids": ["etoh_e"]}, "charge": 0, "formula": "C2H6O", "compartment": "e", "id": "etoh_e"}, {"name": "Ethanol", "notes": {"original_bigg_ids": ["etoh_p"]}, "charge": 0, "formula": "C2H6O", "compartment": "p", "id": "etoh_p"}, {"name": "D-Fructose 1-phosphate", "notes": {"original_bigg_ids": ["f1p_c"]}, "charge": -2, "formula": "C6H11O9P", "compartment": "c", "id": "f1p_c"}, {"name": "D-Fructose 6-phosphate", "notes": {"original_bigg_ids": ["f6p_c"]}, "charge": -2, "formula": "C6H11O9P", "compartment": "c", "id": "f6p_c"}, {"name": "D-Fructose 6-phosphate", "notes": {"original_bigg_ids": ["f6p_e"]}, "charge": -2, 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"Maltose 6'-phosphate", "notes": {"original_bigg_ids": ["malt6p_c"]}, "charge": -2, "formula": "C12H21O14P", "compartment": "c", "id": "malt6p_c"}, {"name": "Maltose", "notes": {"original_bigg_ids": ["malt_c"]}, "charge": 0, "formula": "C12H22O11", "compartment": "c", "id": "malt_c"}, {"name": "Maltose", "notes": {"original_bigg_ids": ["malt_e"]}, "charge": 0, "formula": "C12H22O11", "compartment": "e", "id": "malt_e"}, {"name": "Maltose", "notes": {"original_bigg_ids": ["malt_p"]}, "charge": 0, "formula": "C12H22O11", "compartment": "p", "id": "malt_p"}, {"name": "Maltoheptaose", "notes": {"original_bigg_ids": ["malthp_c"]}, "charge": 0, "formula": "C42H72O36", "compartment": "c", "id": "malthp_c"}, {"name": "Maltohexaose", "notes": {"original_bigg_ids": ["malthx_c"]}, "charge": 0, "formula": "C36H62O31", "compartment": "c", "id": "malthx_c"}, {"name": "Maltohexaose", "notes": {"original_bigg_ids": ["malthx_e"]}, "charge": 0, "formula": "C36H62O31", "compartment": "e", "id": "malthx_e"}, {"name": "Maltohexaose", "notes": {"original_bigg_ids": ["malthx_p"]}, "charge": 0, "formula": "C36H62O31", "compartment": "p", "id": "malthx_p"}, {"name": "Maltopentaose", "notes": {"original_bigg_ids": ["maltpt_c"]}, "charge": 0, "formula": "C30H52O26", "compartment": "c", "id": "maltpt_c"}, {"name": "Maltopentaose", "notes": {"original_bigg_ids": ["maltpt_e"]}, "charge": 0, "formula": "C30H52O26", "compartment": "e", "id": "maltpt_e"}, {"name": "Maltopentaose", "notes": {"original_bigg_ids": ["maltpt_p"]}, "charge": 0, "formula": "C30H52O26", "compartment": "p", "id": "maltpt_p"}, {"name": "Maltotriose", "notes": {"original_bigg_ids": ["malttr_c"]}, "charge": 0, "formula": "C18H32O16", "compartment": "c", "id": "malttr_c"}, {"name": "Maltotriose", "notes": {"original_bigg_ids": ["malttr_e"]}, "charge": 0, "formula": "C18H32O16", "compartment": "e", "id": "malttr_e"}, {"name": "Maltotriose", "notes": {"original_bigg_ids": ["malttr_p"]}, "charge": 0, "formula": "C18H32O16", "compartment": "p", "id": "malttr_p"}, {"name": "Maltotetraose", "notes": {"original_bigg_ids": ["maltttr_c"]}, "charge": 0, "formula": "C24H42O21", "compartment": "c", "id": "maltttr_c"}, {"name": "Maltotetraose", "notes": {"original_bigg_ids": ["maltttr_e"]}, "charge": 0, "formula": "C24H42O21", "compartment": "e", "id": "maltttr_e"}, {"name": "Maltotetraose", "notes": {"original_bigg_ids": ["maltttr_p"]}, "charge": 0, "formula": "C24H42O21", "compartment": "p", "id": "maltttr_p"}, {"name": "D-Mannose 1-phosphate", "notes": {"original_bigg_ids": ["man1p_c"]}, "charge": -2, "formula": "C6H11O9P", "compartment": "c", "id": "man1p_c"}, {"name": "D-Mannose 6-phosphate", "notes": {"original_bigg_ids": ["man6p_c"]}, "charge": -2, "formula": "C6H11O9P", "compartment": "c", "id": "man6p_c"}, {"name": "D-Mannose 6-phosphate", "notes": {"original_bigg_ids": ["man6p_e"]}, "charge": -2, "formula": "C6H11O9P", "compartment": "e", "id": "man6p_e"}, {"name": "D-Mannose 6-phosphate", "notes": {"original_bigg_ids": ["man6p_p"]}, "charge": -2, "formula": "C6H11O9P", "compartment": "p", "id": "man6p_p"}, {"name": "2(alpha-D-Mannosyl-6-phosphate)-D-glycerate", "notes": {"original_bigg_ids": ["man6pglyc_c"]}, "charge": -3, "formula": "C9H14O12P", "compartment": "c", "id": "man6pglyc_c"}, {"name": "D-Mannose", "notes": {"original_bigg_ids": ["man_c"]}, "charge": 0, "formula": "C6H12O6", "compartment": "c", "id": "man_c"}, {"name": "D-Mannose", "notes": {"original_bigg_ids": ["man_e"]}, "charge": 0, "formula": "C6H12O6", "compartment": "e", "id": "man_e"}, {"name": "D-Mannose", "notes": {"original_bigg_ids": ["man_p"]}, "charge": 0, "formula": "C6H12O6", "compartment": "p", "id": "man_p"}, {"name": "D-Mannonate", "notes": {"original_bigg_ids": ["mana_c"]}, "charge": -1, "formula": "C6H11O7", "compartment": "c", "id": "mana_c"}, {"name": "2(alpha-D-Mannosyl)-D-glycerate", "notes": {"original_bigg_ids": ["manglyc_e"]}, "charge": -1, "formula": "C9H15O9", "compartment": "e", "id": "manglyc_e"}, {"name": "2(alpha-D-Mannosyl)-D-glycerate", "notes": {"original_bigg_ids": ["manglyc_p"]}, "charge": -1, "formula": "C9H15O9", "compartment": "p", "id": "manglyc_p"}, {"name": "Melibiose", "notes": {"original_bigg_ids": ["melib_c"]}, "charge": 0, "formula": "C12H22O11", "compartment": "c", "id": "melib_c"}, {"name": "Melibiose", "notes": {"original_bigg_ids": ["melib_e"]}, "charge": 0, "formula": "C12H22O11", "compartment": "e", "id": "melib_e"}, {"name": "Melibiose", "notes": {"original_bigg_ids": ["melib_p"]}, "charge": 0, "formula": "C12H22O11", "compartment": "p", "id": "melib_p"}, {"name": "Mercaptopyruvate", "notes": {"original_bigg_ids": ["mercppyr_c"]}, "charge": -1, "formula": "C3H3O3S", "compartment": "c", "id": "mercppyr_c"}, {"name": "D-Methionine", "notes": {"original_bigg_ids": ["met_DASH_D_c"]}, "charge": 0, "formula": "C5H10NO2S", "compartment": "c", "id": "met__D_c"}, {"name": "D-Methionine", "notes": {"original_bigg_ids": ["met_DASH_D_e"]}, "charge": 0, "formula": "C5H10NO2S", "compartment": "e", "id": "met__D_e"}, {"name": "D-Methionine", "notes": {"original_bigg_ids": ["met_DASH_D_p"]}, "charge": 0, "formula": "C5H10NO2S", "compartment": "p", "id": "met__D_p"}, {"name": "L-Methionine", "notes": {"original_bigg_ids": ["met_DASH_L_c"]}, "charge": 0, "formula": "C5H11NO2S", "compartment": "c", "id": "met__L_c"}, {"name": "L-Methionine", "notes": {"original_bigg_ids": ["met_DASH_L_e"]}, "charge": 0, "formula": "C5H11NO2S", "compartment": "e", "id": "met__L_e"}, {"name": "L-Methionine", "notes": {"original_bigg_ids": ["met_DASH_L_p"]}, "charge": 0, "formula": "C5H11NO2S", "compartment": "p", "id": "met__L_p"}, {"name": "5,10-Methenyltetrahydrofolate", "notes": {"original_bigg_ids": ["methf_c"]}, "charge": -1, "formula": "C20H20N7O6", "compartment": "c", "id": "methf_c"}, {"name": "L-methionine-R-sulfoxide", "notes": {"original_bigg_ids": ["metsox_DASH_R_DASH_L_c"]}, "charge": 0, "formula": "C5H11NO3S", "compartment": "c", "id": "metsox_R__L_c"}, {"name": "L-methionine-R-sulfoxide", "notes": {"original_bigg_ids": ["metsox_DASH_R_DASH_L_e"]}, "charge": 0, "formula": "C5H11NO3S", "compartment": "e", "id": "metsox_R__L_e"}, {"name": "L-methionine-R-sulfoxide", "notes": {"original_bigg_ids": ["metsox_DASH_R_DASH_L_p"]}, "charge": 0, "formula": "C5H11NO3S", "compartment": "p", "id": "metsox_R__L_p"}, {"name": "L-Methionine Sulfoxide", "notes": {"original_bigg_ids": ["metsox_DASH_S_DASH_L_c"]}, "charge": 0, "formula": "C5H11NO3S", "compartment": "c", "id": "metsox_S__L_c"}, {"name": "L-Methionine Sulfoxide", "notes": {"original_bigg_ids": ["metsox_DASH_S_DASH_L_e"]}, "charge": 0, "formula": "C5H11NO3S", "compartment": "e", "id": "metsox_S__L_e"}, {"name": "L-Methionine Sulfoxide", "notes": {"original_bigg_ids": ["metsox_DASH_S_DASH_L_p"]}, "charge": 0, "formula": "C5H11NO3S", "compartment": "p", "id": "metsox_S__L_p"}, {"name": "L-Methionyl-tRNA (Met)", "notes": {"original_bigg_ids": ["mettrna_c"]}, "charge": 1, "formula": "C5H10NOSR", "compartment": "c", "id": "mettrna_c"}, {"name": "Magnesium", "notes": {"original_bigg_ids": ["mg2_c"]}, "charge": 2, "formula": "Mg", "compartment": "c", "id": "mg2_c"}, {"name": "Magnesium", "notes": {"original_bigg_ids": ["mg2_e"]}, "charge": 2, "formula": "Mg", "compartment": "e", "id": "mg2_e"}, {"name": "Magnesium", "notes": {"original_bigg_ids": ["mg2_p"]}, "charge": 2, "formula": "Mg", "compartment": "p", "id": "mg2_p"}, {"name": "1D-myo-Inositol 1-phosphate", "notes": {"original_bigg_ids": ["mi1p_DASH_D_c"]}, "charge": -2, "formula": "C6H11O9P", "compartment": "c", "id": "mi1p__D_c"}, {"name": "Methylisocitrate", "notes": {"original_bigg_ids": ["micit_c"]}, "charge": -3, "formula": "C7H7O7", "compartment": "c", "id": "micit_c"}, {"name": "Myo-Inositol hexakisphosphate", "notes": {"original_bigg_ids": ["minohp_e"]}, "charge": -12, "formula": "C6H6O24P6", "compartment": "e", "id": "minohp_e"}, {"name": "Myo-Inositol hexakisphosphate", "notes": 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["mmet_p"]}, "charge": 1, "formula": "C6H14NO2S", "compartment": "p", "id": "mmet_p"}, {"name": "Mn2+", "notes": {"original_bigg_ids": ["mn2_c"]}, "charge": 2, "formula": "Mn", "compartment": "c", "id": "mn2_c"}, {"name": "Mn2+", "notes": {"original_bigg_ids": ["mn2_e"]}, "charge": 2, "formula": "Mn", "compartment": "e", "id": "mn2_e"}, {"name": "Mn2+", "notes": {"original_bigg_ids": ["mn2_p"]}, "charge": 2, "formula": "Mn", "compartment": "p", "id": "mn2_p"}, {"name": "D-Mannitol 1-phosphate", "notes": {"original_bigg_ids": ["mnl1p_c"]}, "charge": -2, "formula": "C6H13O9P", "compartment": "c", "id": "mnl1p_c"}, {"name": "D-Mannitol", "notes": {"original_bigg_ids": ["mnl_e"]}, "charge": 0, "formula": "C6H14O6", "compartment": "e", "id": "mnl_e"}, {"name": "D-Mannitol", "notes": {"original_bigg_ids": ["mnl_p"]}, "charge": 0, "formula": "C6H14O6", "compartment": "p", "id": "mnl_p"}, {"name": "Molybdate", "notes": {"original_bigg_ids": ["mobd_c"]}, "charge": -2, "formula": "MoO4", 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"C114H172N22O59", "compartment": "p", "id": "murein5px4px4p_p"}, {"name": "Myristoyl-ACP (n-C14:0ACP)", "notes": {"original_bigg_ids": ["myrsACP_c"]}, "charge": -1, "formula": "C25H47N2O8PRS", "compartment": "c", "id": "myrsACP_c"}, {"name": "Nitrous oxide", "notes": {"original_bigg_ids": ["n2o_c"]}, "charge": 0, "formula": "N2O", "compartment": "c", "id": "n2o_c"}, {"name": "Nitrous oxide", "notes": {"original_bigg_ids": ["n2o_e"]}, "charge": 0, "formula": "N2O", "compartment": "e", "id": "n2o_e"}, {"name": "Nitrous oxide", "notes": {"original_bigg_ids": ["n2o_p"]}, "charge": 0, "formula": "N2O", "compartment": "p", "id": "n2o_p"}, {"name": "N8-Acetylspermidine", "notes": {"original_bigg_ids": ["n8aspmd_c"]}, "charge": 2, "formula": "C9H23N3O", "compartment": "c", "id": "n8aspmd_c"}, {"name": "Sodium", "notes": {"original_bigg_ids": ["na1_c"]}, "charge": 1, "formula": "Na", "compartment": "c", "id": "na1_c"}, {"name": "Sodium", "notes": {"original_bigg_ids": ["na1_e"]}, "charge": 1, 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"notes": {"original_bigg_ids": ["ni2_e"]}, "charge": 2, "formula": "Ni", "compartment": "e", "id": "ni2_e"}, {"name": "Nickel", "notes": {"original_bigg_ids": ["ni2_p"]}, "charge": 2, "formula": "Ni", "compartment": "p", "id": "ni2_p"}, {"name": "Nicotinate D-ribonucleotide", "notes": {"original_bigg_ids": ["nicrnt_c"]}, "charge": -2, "formula": "C11H12NO9P", "compartment": "c", "id": "nicrnt_c"}, {"name": "NMN", "notes": {"original_bigg_ids": ["nmn_c"]}, "charge": -1, "formula": "C11H14N2O8P", "compartment": "c", "id": "nmn_c"}, {"name": "NMN", "notes": {"original_bigg_ids": ["nmn_e"]}, "charge": -1, "formula": "C11H14N2O8P", "compartment": "e", "id": "nmn_e"}, {"name": "NMN", "notes": {"original_bigg_ids": ["nmn_p"]}, "charge": -1, "formula": "C11H14N2O8P", "compartment": "p", "id": "nmn_p"}, {"name": "Nitrite", "notes": {"original_bigg_ids": ["no2_c"]}, "charge": -1, "formula": "NO2", "compartment": "c", "id": "no2_c"}, {"name": "Nitrite", "notes": {"original_bigg_ids": ["no2_e"]}, 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"(O16 antigen)x2 undecaprenyl diphosphate", "notes": {"original_bigg_ids": ["o16a2und_p"]}, "charge": -2, "formula": "C123H200N2O57P2", "compartment": "p", "id": "o16a2und_p"}, {"name": "(O16 antigen)x3 undecaprenyl diphosphate", "notes": {"original_bigg_ids": ["o16a3und_p"]}, "charge": -2, "formula": "C157H255N3O82P2", "compartment": "p", "id": "o16a3und_p"}, {"name": "(O16 antigen)x4 core oligosaccharide lipid A", "notes": {"original_bigg_ids": ["o16a4colipa_e"]}, "charge": -11, "formula": "C312H523N6O200P4", "compartment": "e", "id": "o16a4colipa_e"}, {"name": "(O16 antigen)x4 core oligosaccharide lipid A", "notes": {"original_bigg_ids": ["o16a4colipa_p"]}, "charge": -11, "formula": "C312H523N6O200P4", "compartment": "p", "id": "o16a4colipa_p"}, {"name": "(O16 antigen)x4 undecaprenyl diphosphate", "notes": {"original_bigg_ids": ["o16a4und_p"]}, "charge": -2, "formula": "C191H310N4O107P2", "compartment": "p", "id": "o16a4und_p"}, {"name": "O16 antigen undecaprenyl diphosphate", "notes": {"original_bigg_ids": ["o16aund_c"]}, "charge": -2, "formula": "C89H145N1O32P2", "compartment": "c", "id": "o16aund_c"}, {"name": "O16 antigen undecaprenyl diphosphate", "notes": {"original_bigg_ids": ["o16aund_p"]}, "charge": -2, "formula": "C89H145N1O32P2", "compartment": "p", "id": "o16aund_p"}, {"name": "O2", "notes": {"original_bigg_ids": ["o2_c"]}, "charge": 0, "formula": "O2", "compartment": "c", "id": "o2_c"}, {"name": "O2", "notes": {"original_bigg_ids": ["o2_e"]}, "charge": 0, "formula": "O2", "compartment": "e", "id": "o2_e"}, {"name": "O2", "notes": {"original_bigg_ids": ["o2_p"]}, "charge": 0, "formula": "O2", "compartment": "p", "id": "o2_p"}, {"name": "Superoxide anion", "notes": {"original_bigg_ids": ["o2s_c"]}, "charge": -1, "formula": "O2", "compartment": "c", "id": "o2s_c"}, {"name": "Superoxide anion", "notes": {"original_bigg_ids": ["o2s_e"]}, "charge": -1, "formula": "O2", "compartment": "e", "id": "o2s_e"}, {"name": "Superoxide anion", "notes": {"original_bigg_ids": ["o2s_p"]}, "charge": -1, "formula": "O2", "compartment": "p", "id": "o2s_p"}, {"name": "Oxaloacetate", "notes": {"original_bigg_ids": ["oaa_c"]}, "charge": -2, "formula": "C4H2O5", "compartment": "c", "id": "oaa_c"}, {"name": "Trans-Oct-2-enoyl-CoA", "notes": {"original_bigg_ids": ["oc2coa_c"]}, "charge": -4, "formula": "C29H44N7O17P3S", "compartment": "c", "id": "oc2coa_c"}, {"name": "Octanoyl-ACP (n-C8:0ACP)", "notes": {"original_bigg_ids": ["ocACP_c"]}, "charge": -1, "formula": "C19H35N2O8PRS", "compartment": "c", "id": "ocACP_c"}, {"name": "Octanoyl-CoA (n-C8:0CoA)", "notes": {"original_bigg_ids": ["occoa_c"]}, "charge": -4, "formula": "C29H46N7O17P3S", "compartment": "c", "id": "occoa_c"}, {"name": "Octadecanoyl-ACP (n-C18:0ACP)", "notes": {"original_bigg_ids": ["ocdcaACP_c"]}, "charge": -1, "formula": "C29H55N2O8PRS", "compartment": "c", "id": "ocdcaACP_c"}, {"name": "Octadecanoate (n-C18:0)", "notes": {"original_bigg_ids": ["ocdca_c"]}, "charge": -1, "formula": "C18H35O2", "compartment": "c", "id": "ocdca_c"}, {"name": "Octadecanoate (n-C18:0)", "notes": {"original_bigg_ids": ["ocdca_e"]}, "charge": -1, "formula": "C18H35O2", "compartment": "e", "id": "ocdca_e"}, {"name": "Octadecanoate (n-C18:0)", "notes": {"original_bigg_ids": ["ocdca_p"]}, "charge": -1, "formula": "C18H35O2", "compartment": "p", "id": "ocdca_p"}, {"name": "Octadecenoate (n-C18:1)", "notes": {"original_bigg_ids": ["ocdcea_c"]}, "charge": -1, "formula": "C18H33O2", "compartment": "c", "id": "ocdcea_c"}, {"name": "Octadecenoate (n-C18:1)", "notes": {"original_bigg_ids": ["ocdcea_e"]}, "charge": -1, "formula": "C18H33O2", "compartment": "e", "id": "ocdcea_e"}, {"name": "Octadecenoate (n-C18:1)", "notes": {"original_bigg_ids": ["ocdcea_p"]}, "charge": -1, "formula": "C18H33O2", "compartment": "p", "id": "ocdcea_p"}, {"name": "Octanoate (n-C8:0)", "notes": {"original_bigg_ids": ["octa_c"]}, "charge": -1, "formula": "C8H15O2", "compartment": "c", "id": "octa_c"}, {"name": "Octanoate (n-C8:0)", "notes": {"original_bigg_ids": ["octa_e"]}, "charge": -1, "formula": "C8H15O2", "compartment": "e", "id": "octa_e"}, {"name": "Octanoate (n-C8:0)", "notes": {"original_bigg_ids": ["octa_p"]}, "charge": -1, "formula": "C8H15O2", "compartment": "p", "id": "octa_p"}, {"name": "All-trans-Octaprenyl diphosphate", "notes": {"original_bigg_ids": ["octdp_c"]}, "charge": -3, "formula": "C40H65O7P2", "compartment": "c", "id": "octdp_c"}, {"name": "Cis-octadec-11-enoyl-[acyl-carrier protein] (n-C18:1)", "notes": {"original_bigg_ids": ["octeACP_c"]}, "charge": -1, "formula": "C29H53N2O8PRS", "compartment": "c", "id": "octeACP_c"}, {"name": "Trans-Octadec-2-enoyl-CoA", "notes": {"original_bigg_ids": ["od2coa_c"]}, "charge": -4, "formula": "C39H64N7O17P3S", "compartment": "c", "id": "od2coa_c"}, {"name": "Octadecenoyl-CoA (n-C18:1CoA)", "notes": {"original_bigg_ids": ["odecoa_c"]}, "charge": -4, "formula": "C39H64N7O17P3S", "compartment": "c", "id": "odecoa_c"}, {"name": "2-Oxo-3-hydroxy-4-phosphobutanoate", "notes": {"original_bigg_ids": ["ohpb_c"]}, "charge": -3, "formula": "C4H4O8P", "compartment": "c", "id": "ohpb_c"}, {"name": "2-Oxopent-4-enoate", "notes": {"original_bigg_ids": ["op4en_c"]}, "charge": -1, "formula": "C5H5O3", "compartment": "c", "id": "op4en_c"}, {"name": "Ornithine", "notes": {"original_bigg_ids": ["orn_c"]}, "charge": 1, "formula": "C5H13N2O2", "compartment": "c", "id": "orn_c"}, {"name": "Ornithine", "notes": {"original_bigg_ids": ["orn_e"]}, "charge": 1, "formula": "C5H13N2O2", "compartment": "e", "id": "orn_e"}, {"name": "Ornithine", "notes": {"original_bigg_ids": ["orn_p"]}, "charge": 1, "formula": "C5H13N2O2", "compartment": "p", "id": "orn_p"}, {"name": "Orotidine 5'-phosphate", "notes": {"original_bigg_ids": ["orot5p_c"]}, "charge": -3, "formula": "C10H10N2O11P", "compartment": "c", "id": "orot5p_c"}, {"name": "Orotate", "notes": {"original_bigg_ids": ["orot_c"]}, "charge": -1, "formula": "C5H3N2O4", "compartment": "c", "id": "orot_c"}, {"name": "Orotate", "notes": {"original_bigg_ids": ["orot_e"]}, "charge": -1, "formula": "C5H3N2O4", "compartment": "e", "id": "orot_e"}, {"name": "Orotate", "notes": {"original_bigg_ids": ["orot_p"]}, "charge": -1, "formula": "C5H3N2O4", "compartment": "p", "id": "orot_p"}, {"name": "Oxamate", "notes": {"original_bigg_ids": ["oxam_c"]}, "charge": -1, "formula": "C2H2NO3", "compartment": "c", "id": "oxam_c"}, {"name": "Oxalureate", "notes": {"original_bigg_ids": ["oxur_c"]}, "charge": -1, "formula": "C3H3N2O4", "compartment": "c", "id": "oxur_c"}, {"name": "1,2-didodecanoyl-sn-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["pa120_c"]}, "charge": -2, "formula": "C27H51O8P1", "compartment": "c", "id": "pa120_c"}, {"name": "1,2-didodecanoyl-sn-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["pa120_p"]}, "charge": -2, "formula": "C27H51O8P1", "compartment": "p", "id": "pa120_p"}, {"name": "1,2-ditetradecanoyl-sn-glycerol 3-phosphate", 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"id": "pa160_p"}, {"name": "1,2-dihexadec-9-enoyl-sn-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["pa161_c"]}, "charge": -2, "formula": "C35H63O8P1", "compartment": "c", "id": "pa161_c"}, {"name": "1,2-dihexadec-9-enoyl-sn-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["pa161_p"]}, "charge": -2, "formula": "C35H63O8P1", "compartment": "p", "id": "pa161_p"}, {"name": "1,2-dioctadecanoyl-sn-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["pa180_c"]}, "charge": -2, "formula": "C39H75O8P1", "compartment": "c", "id": "pa180_c"}, {"name": "1,2-dioctadecanoyl-sn-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["pa180_p"]}, "charge": -2, "formula": "C39H75O8P1", "compartment": "p", "id": "pa180_p"}, {"name": "1,2-dioctadec-11-enoyl-sn-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["pa181_c"]}, "charge": -2, "formula": "C39H71O8P1", "compartment": "c", "id": "pa181_c"}, {"name": "1,2-dioctadec-11-enoyl-sn-glycerol 3-phosphate", "notes": {"original_bigg_ids": ["pa181_p"]}, "charge": -2, "formula": "C39H71O8P1", "compartment": "p", "id": "pa181_p"}, {"name": "Phenylacetic acid", "notes": {"original_bigg_ids": ["pac_c"]}, "charge": -1, "formula": "C8H7O2", "compartment": "c", "id": "pac_c"}, {"name": "Phenylacetaldehyde", "notes": {"original_bigg_ids": ["pacald_c"]}, "charge": 0, "formula": "C8H8O", "compartment": "c", "id": "pacald_c"}, {"name": "Phenylacetaldehyde", "notes": {"original_bigg_ids": ["pacald_e"]}, "charge": 0, "formula": "C8H8O", "compartment": "e", "id": "pacald_e"}, {"name": "Phenylacetaldehyde", "notes": {"original_bigg_ids": ["pacald_p"]}, "charge": 0, "formula": "C8H8O", "compartment": "p", "id": "pacald_p"}, {"name": "Palmitoyl-ACP (n-C16:0ACP)", "notes": {"original_bigg_ids": ["palmACP_c"]}, "charge": -1, "formula": "C27H51N2O8PRS", "compartment": "c", "id": "palmACP_c"}, {"name": "Pantetheine 4'-phosphate", "notes": {"original_bigg_ids": ["pan4p_c"]}, "charge": -2, "formula": "C11H21N2O7PS", "compartment": "c", "id": "pan4p_c"}, {"name": "(R)-Pantoate", "notes": {"original_bigg_ids": ["pant_DASH_R_c"]}, "charge": -1, "formula": "C6H11O4", "compartment": "c", "id": "pant__R_c"}, {"name": "Adenosine 3',5'-bisphosphate", "notes": {"original_bigg_ids": ["pap_c"]}, "charge": -4, "formula": "C10H11N5O10P2", "compartment": "c", "id": "pap_c"}, {"name": "3'-Phosphoadenylyl sulfate", "notes": {"original_bigg_ids": ["paps_c"]}, "charge": -4, "formula": "C10H11N5O13P2S", "compartment": "c", "id": "paps_c"}, {"name": "Pyridoxine 5'-phosphate", "notes": {"original_bigg_ids": ["pdx5p_c"]}, "charge": -2, "formula": "C8H10NO6P", "compartment": "c", "id": "pdx5p_c"}, {"name": "Phosphatidylethanolamine (didodecanoyl, n-C12:0)", "notes": {"original_bigg_ids": ["pe120_c"]}, "charge": 0, "formula": "C29H58N1O8P1", "compartment": "c", "id": "pe120_c"}, {"name": "Phosphatidylethanolamine (didodecanoyl, n-C12:0)", "notes": {"original_bigg_ids": ["pe120_p"]}, "charge": 0, "formula": "C29H58N1O8P1", "compartment": "p", "id": "pe120_p"}, {"name": "Phosphatidylethanolamine (ditetradecanoyl, n-C14:0)", "notes": {"original_bigg_ids": ["pe140_c"]}, "charge": 0, "formula": "C33H66N1O8P1", "compartment": "c", "id": "pe140_c"}, {"name": "Phosphatidylethanolamine (ditetradecanoyl, n-C14:0)", "notes": {"original_bigg_ids": ["pe140_p"]}, "charge": 0, "formula": "C33H66N1O8P1", "compartment": "p", "id": "pe140_p"}, {"name": "Phosphatidylethanolamine (ditetradec-7-enoyl, n-C14:1)", "notes": {"original_bigg_ids": ["pe141_c"]}, "charge": 0, "formula": "C33H62N1O8P1", "compartment": "c", "id": "pe141_c"}, {"name": "Phosphatidylethanolamine (ditetradec-7-enoyl, n-C14:1)", "notes": {"original_bigg_ids": ["pe141_p"]}, "charge": 0, "formula": "C33H62N1O8P1", "compartment": "p", "id": "pe141_p"}, {"name": "Phosphatidylethanolamine (dihexadecanoyl, n-C16:0)", "notes": {"original_bigg_ids": ["pe160_c"]}, "charge": 0, "formula": "C37H74N1O8P1", "compartment": "c", "id": "pe160_c"}, 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