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{"arbt_e": -1.0}, "id": "EX_arbt_e", "gene_reaction_rule": ""}, {"name": "Aerobactin minus Fe3 exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_arbtn_LPAREN_e_RPAREN_"]}, "metabolites": {"arbtn_e": -1.0}, "id": "EX_arbtn_e", "gene_reaction_rule": ""}, {"name": "Aerobactin exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_arbtn_DASH_fe3_LPAREN_e_RPAREN_"]}, "metabolites": {"arbtn_fe3_e": -1.0}, "id": "EX_arbtn_fe3_e", "gene_reaction_rule": ""}, {"name": "L-Arginine exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_arg_DASH_L_LPAREN_e_RPAREN_"]}, "metabolites": {"arg__L_e": -1.0}, "id": "EX_arg__L_e", "gene_reaction_rule": ""}, {"name": "L-Ascorbate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_ascb_DASH_L_LPAREN_e_RPAREN_"]}, "metabolites": {"ascb__L_e": -1.0}, "id": "EX_ascb__L_e", "gene_reaction_rule": ""}, {"name": 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"Fe(III)hydroxamate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_fe3hox_LPAREN_e_RPAREN_"]}, "metabolites": {"fe3hox_e": -1.0}, "id": "EX_fe3hox_e", "gene_reaction_rule": ""}, {"name": "Fe(III)hydoxamate, unloaded exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_fe3hox_DASH_un_LPAREN_e_RPAREN_"]}, "metabolites": {"fe3hox_un_e": -1.0}, "id": "EX_fe3hox_un_e", "gene_reaction_rule": ""}, {"name": "Ferrichrome exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_fecrm_LPAREN_e_RPAREN_"]}, "metabolites": {"fecrm_e": -1.0}, "id": "EX_fecrm_e", "gene_reaction_rule": ""}, {"name": "Ferrichrome minus Fe(III) exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_fecrm_DASH_un_LPAREN_e_RPAREN_"]}, "metabolites": {"fecrm_un_e": -1.0}, "id": "EX_fecrm_un_e", "gene_reaction_rule": ""}, {"name": "Fe-enterobactin exchange", "upper_bound": 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["EX_lcts_LPAREN_e_RPAREN_"]}, "metabolites": {"lcts_e": -1.0}, "id": "EX_lcts_e", "gene_reaction_rule": ""}, {"name": "L-Leucine exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_leu_DASH_L_LPAREN_e_RPAREN_"]}, "metabolites": {"leu__L_e": -1.0}, "id": "EX_leu__L_e", "gene_reaction_rule": ""}, {"name": "KDO(2)-lipid (A) exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_lipa_LPAREN_e_RPAREN_"]}, "metabolites": {"lipa_e": -1.0}, "id": "EX_lipa_e", "gene_reaction_rule": ""}, {"name": "Cold adapted KDO(2)-lipid (A) exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_lipa_cold_LPAREN_e_RPAREN_"]}, "metabolites": {"lipa_cold_e": -1.0}, "id": "EX_lipa_cold_e", "gene_reaction_rule": ""}, {"name": "Lipoate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_lipoate_LPAREN_e_RPAREN_"]}, "metabolites": {"lipoate_e": -1.0}, "id": 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"name": "23cUMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["23CUMPtex"]}, "metabolites": {"23cump_p": 1.0, "23cump_e": -1.0}, "id": "23CUMPtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "2,3-diaminopropionate transport in via proton symport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["23DAPPAt2pp"]}, "metabolites": {"h_p": -1.0, "23dappa_p": -1.0, "23dappa_c": 1.0, "h_c": 1.0}, "id": "23DAPPAt2pp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "2,3-diaminopropionate transport via diffusion", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["23DAPPAtex"]}, "metabolites": {"23dappa_e": -1.0, "23dappa_p": 1.0}, "id": "23DAPPAtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "2',3'-cyclic-nucleotide phosphodiesterase (UMP) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["23PDE2pp"]}, "metabolites": {"h2o_p": -1.0, "23cump_p": -1.0, "3ump_p": 1.0, "h_p": 1.0}, "id": "23PDE2pp", "gene_reaction_rule": "ECS88_4807"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "2',3'-cyclic-nucleotide phosphodiesterase (CMP) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["23PDE4pp"]}, "metabolites": {"h2o_p": -1.0, "3cmp_p": 1.0, "23ccmp_p": -1.0, "h_p": 1.0}, "id": "23PDE4pp", "gene_reaction_rule": "ECS88_4807"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "2',3'-cyclic-nucleotide phosphodiesterase (AMP) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["23PDE7pp"]}, "metabolites": {"3amp_p": 1.0, "h2o_p": -1.0, "h_p": 1.0, "23camp_p": -1.0}, "id": "23PDE7pp", "gene_reaction_rule": "ECS88_4807"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "2',3'-cyclic-nucleotide phosphodiesterase (GMP) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["23PDE9pp"]}, "metabolites": {"23cgmp_p": -1.0, "h_p": 1.0, "3gmp_p": 1.0, "h2o_p": -1.0}, "id": "23PDE9pp", "gene_reaction_rule": "ECS88_4807"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Meso-2,6-Diaminoheptanedioate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["26DAHtex"]}, "metabolites": {"26dap__M_e": -1.0, "26dap__M_p": 1.0}, "id": "26DAHtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphatidate (n-C12:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPA120tipp"]}, "metabolites": {"2ddecg3p_c": 1.0, "2ddecg3p_p": -1.0}, "id": "2AGPA120tipp", "gene_reaction_rule": "ECS88_3130"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphatidate (n-C14:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPA140tipp"]}, "metabolites": {"2tdecg3p_c": 1.0, "2tdecg3p_p": -1.0}, "id": "2AGPA140tipp", "gene_reaction_rule": "ECS88_3130"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphatidate (n-C14:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPA141tipp"]}, "metabolites": {"2tdec7eg3p_p": -1.0, "2tdec7eg3p_c": 1.0}, "id": "2AGPA141tipp", "gene_reaction_rule": "ECS88_3130"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphatidate (n-C16:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPA160tipp"]}, "metabolites": {"2hdecg3p_c": 1.0, "2hdecg3p_p": -1.0}, "id": "2AGPA160tipp", "gene_reaction_rule": "ECS88_3130"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphatidate (n-C16:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPA161tipp"]}, "metabolites": {"2hdec9eg3p_c": 1.0, "2hdec9eg3p_p": -1.0}, "id": "2AGPA161tipp", "gene_reaction_rule": "ECS88_3130"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphatidate (n-C18:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPA180tipp"]}, "metabolites": {"2odecg3p_p": -1.0, "2odecg3p_c": 1.0}, "id": "2AGPA180tipp", "gene_reaction_rule": "ECS88_3130"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphatidate (n-C18:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPA181tipp"]}, "metabolites": {"2odec11eg3p_p": -1.0, "2odec11eg3p_c": 1.0}, "id": "2AGPA181tipp", "gene_reaction_rule": "ECS88_3130"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C12:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPE120tipp"]}, "metabolites": {"2agpe120_p": -1.0, "2agpe120_c": 1.0}, "id": "2AGPE120tipp", "gene_reaction_rule": "ECS88_3130"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C14:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPE140tipp"]}, "metabolites": {"2agpe140_c": 1.0, "2agpe140_p": -1.0}, "id": "2AGPE140tipp", "gene_reaction_rule": "ECS88_3130"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C14:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPE141tipp"]}, "metabolites": {"2agpe141_c": 1.0, "2agpe141_p": -1.0}, "id": "2AGPE141tipp", "gene_reaction_rule": "ECS88_3130"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C16:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPE160tipp"]}, "metabolites": {"2agpe160_p": -1.0, "2agpe160_c": 1.0}, "id": "2AGPE160tipp", "gene_reaction_rule": "ECS88_3130"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C16:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPE161tipp"]}, "metabolites": {"2agpe161_p": -1.0, "2agpe161_c": 1.0}, "id": "2AGPE161tipp", "gene_reaction_rule": "ECS88_3130"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C18:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPE180tipp"]}, "metabolites": {"2agpe180_c": 1.0, "2agpe180_p": -1.0}, "id": "2AGPE180tipp", "gene_reaction_rule": "ECS88_3130"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C18:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPE181tipp"]}, "metabolites": {"2agpe181_c": 1.0, "2agpe181_p": -1.0}, "id": "2AGPE181tipp", "gene_reaction_rule": "ECS88_3130"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-ethanolamine acyltransferase (n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPEAT120"]}, "metabolites": {"pe120_c": 1.0, "atp_c": -1.0, "ddca_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "2agpe120_c": -1.0}, "id": "2AGPEAT120", "gene_reaction_rule": "ECS88_3131"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-ethanolamine acyltransferase (n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPEAT140"]}, "metabolites": {"atp_c": -1.0, "pe140_c": 1.0, "ppi_c": 1.0, "2agpe140_c": -1.0, "amp_c": 1.0, "ttdca_c": -1.0}, "id": "2AGPEAT140", "gene_reaction_rule": "ECS88_3131"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-ethanolamine acyltransferase (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPEAT141"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "2agpe141_c": -1.0, "amp_c": 1.0, "pe141_c": 1.0, "ttdcea_c": -1.0}, "id": "2AGPEAT141", "gene_reaction_rule": "ECS88_3131"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-ethanolamine acyltransferase (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPEAT160"]}, "metabolites": {"atp_c": -1.0, "2agpe160_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "hdca_c": -1.0, "pe160_c": 1.0}, "id": "2AGPEAT160", "gene_reaction_rule": "ECS88_3131"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-ethanolamine acyltransferase (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPEAT161"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "2agpe161_c": -1.0, "hdcea_c": -1.0, "pe161_c": 1.0, "amp_c": 1.0}, "id": "2AGPEAT161", "gene_reaction_rule": "ECS88_3131"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-ethanolamine acyltransferase (n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPEAT180"]}, "metabolites": {"pe180_c": 1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "ocdca_c": -1.0, "2agpe180_c": -1.0}, "id": "2AGPEAT180", "gene_reaction_rule": "ECS88_3131"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-ethanolamine acyltransferase (n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPEAT181"]}, "metabolites": {"ocdcea_c": -1.0, "atp_c": -1.0, "2agpe181_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "pe181_c": 1.0}, "id": "2AGPEAT181", "gene_reaction_rule": "ECS88_3131"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C12:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPG120tipp"]}, "metabolites": {"2agpg120_c": 1.0, "2agpg120_p": -1.0}, "id": "2AGPG120tipp", "gene_reaction_rule": "ECS88_3130"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C14:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPG140tipp"]}, "metabolites": {"2agpg140_p": -1.0, "2agpg140_c": 1.0}, "id": "2AGPG140tipp", "gene_reaction_rule": "ECS88_3130"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C14:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPG141tipp"]}, "metabolites": {"2agpg141_p": -1.0, "2agpg141_c": 1.0}, "id": "2AGPG141tipp", "gene_reaction_rule": "ECS88_3130"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPG160tipp"]}, "metabolites": {"2agpg160_c": 1.0, "2agpg160_p": -1.0}, "id": "2AGPG160tipp", "gene_reaction_rule": "ECS88_3130"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPG161tipp"]}, "metabolites": {"2agpg161_c": 1.0, "2agpg161_p": -1.0}, "id": "2AGPG161tipp", "gene_reaction_rule": "ECS88_3130"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPG180tipp"]}, "metabolites": {"2agpg180_p": -1.0, "2agpg180_c": 1.0}, "id": "2AGPG180tipp", "gene_reaction_rule": "ECS88_3130"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPG181tipp"]}, "metabolites": {"2agpg181_p": -1.0, "2agpg181_c": 1.0}, "id": "2AGPG181tipp", "gene_reaction_rule": "ECS88_3130"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-glycerol acyltransferase (n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPGAT120"]}, "metabolites": {"atp_c": -1.0, "ddca_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "pg120_c": 1.0, "2agpg120_c": -1.0}, "id": "2AGPGAT120", "gene_reaction_rule": "ECS88_3131"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-glycerol acyltransferase (n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPGAT140"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "pg140_c": 1.0, "amp_c": 1.0, "2agpg140_c": -1.0, "ttdca_c": -1.0}, "id": "2AGPGAT140", "gene_reaction_rule": "ECS88_3131"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-glycerol acyltransferase (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPGAT141"]}, "metabolites": {"2agpg141_c": -1.0, "atp_c": -1.0, "pg141_c": 1.0, "ppi_c": 1.0, "amp_c": 1.0, "ttdcea_c": -1.0}, "id": "2AGPGAT141", "gene_reaction_rule": "ECS88_3131"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-glycerol acyltransferase (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPGAT160"]}, "metabolites": {"2agpg160_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "pg160_c": 1.0, "hdca_c": -1.0}, "id": "2AGPGAT160", "gene_reaction_rule": "ECS88_3131"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-glycerol acyltransferase (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPGAT161"]}, "metabolites": {"atp_c": -1.0, "2agpg161_c": -1.0, "ppi_c": 1.0, "hdcea_c": -1.0, "pg161_c": 1.0, "amp_c": 1.0}, "id": "2AGPGAT161", "gene_reaction_rule": "ECS88_3131"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-glycerol acyltransferase (n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPGAT180"]}, "metabolites": {"pg180_c": 1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "ocdca_c": -1.0, "2agpg180_c": -1.0}, "id": "2AGPGAT180", "gene_reaction_rule": "ECS88_3131"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-glycerol acyltransferase (n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPGAT181"]}, "metabolites": {"ocdcea_c": -1.0, "atp_c": -1.0, "2agpg181_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "pg181_c": 1.0}, "id": "2AGPGAT181", "gene_reaction_rule": "ECS88_3131"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-Dehydro-L-gulonate reductase to gluconate (NADH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2DGULRGx"]}, "metabolites": {"glcn_c": 1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "2dhguln_c": -1.0}, "id": 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["3AMACHYD"]}, "metabolites": {"3amac_c": -1.0, "h2o_c": -1.0, "h_c": -1.0, "msa_c": 1.0, "nh4_c": 1.0}, "id": "3AMACHYD", "gene_reaction_rule": "ECS88_1025"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "3AMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["3AMPtex"]}, "metabolites": {"3amp_p": 1.0, "3amp_e": -1.0}, "id": "3AMPtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "3CMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["3CMPtex"]}, "metabolites": {"3cmp_p": 1.0, "3cmp_e": -1.0}, "id": "3CMPtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "3GMP transport via diffusion (extracellular to periplasm)", "upper_bound": 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dehydratase (n-C12:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3HAD121"]}, "metabolites": {"h2o_c": 1.0, "t3c5ddeceACP_c": 1.0, "3hcddec5eACP_c": -1.0}, "id": "3HAD121", "gene_reaction_rule": "ECS88_0191 or ECS88_0975"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3HAD140"]}, "metabolites": {"h2o_c": 1.0, "tmrs2eACP_c": 1.0, "3hmrsACP_c": -1.0}, "id": "3HAD140", "gene_reaction_rule": "ECS88_0975 or ECS88_0191"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3HAD141"]}, "metabolites": {"h2o_c": 1.0, "t3c7mrseACP_c": 1.0, "3hcmrs7eACP_c": -1.0}, "id": "3HAD141", "gene_reaction_rule": "ECS88_0975 or ECS88_0191"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3HAD160"]}, "metabolites": {"h2o_c": 1.0, "3hpalmACP_c": -1.0, "tpalm2eACP_c": 1.0}, "id": "3HAD160", "gene_reaction_rule": "ECS88_0975 or ECS88_0191"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3HAD161"]}, "metabolites": {"3hcpalm9eACP_c": -1.0, "t3c9palmeACP_c": 1.0, "h2o_c": 1.0}, "id": "3HAD161", "gene_reaction_rule": "ECS88_0191 or ECS88_0975"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3HAD180"]}, "metabolites": {"toctd2eACP_c": 1.0, "h2o_c": 1.0, "3hoctaACP_c": -1.0}, "id": "3HAD180", "gene_reaction_rule": "ECS88_0975 or ECS88_0191"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3HAD181"]}, "metabolites": {"t3c11vaceACP_c": 1.0, "h2o_c": 1.0, "3hcvac11eACP_c": -1.0}, "id": "3HAD181", "gene_reaction_rule": "ECS88_0975 or ECS88_0191"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C4:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3HAD40"]}, "metabolites": {"3haACP_c": -1.0, "h2o_c": 1.0, "but2eACP_c": 1.0}, "id": "3HAD40", "gene_reaction_rule": "ECS88_0975 or ECS88_0191"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "3-hydroxyacyl-[acyl-carrier-protein] dehydratase (n-C6:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3HAD60"]}, "metabolites": {"3hhexACP_c": -1.0, "thex2eACP_c": 1.0, "h2o_c": 1.0}, "id": "3HAD60", "gene_reaction_rule": "ECS88_0975 or 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synthase (n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3OAS181"]}, "metabolites": {"3ocvac11eACP_c": 1.0, "ACP_c": 1.0, "malACP_c": -1.0, "h_c": -1.0, "co2_c": 1.0, "hdeACP_c": -1.0}, "id": "3OAS181", "gene_reaction_rule": "ECS88_1109"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "3-oxoacyl-[acyl-carrier-protein] synthase (n-C6:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3OAS60"]}, "metabolites": {"3ohexACP_c": 1.0, "butACP_c": -1.0, "ACP_c": 1.0, "malACP_c": -1.0, "h_c": -1.0, "co2_c": 1.0}, "id": "3OAS60", "gene_reaction_rule": "ECS88_1109 or ECS88_2471"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "3-oxoacyl-[acyl-carrier-protein] synthase (n-C8:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3OAS80"]}, "metabolites": {"co2_c": 1.0, "3ooctACP_c": 1.0, "ACP_c": 1.0, "malACP_c": -1.0, "h_c": -1.0, "hexACP_c": -1.0}, "id": "3OAS80", "gene_reaction_rule": "ECS88_2471 or ECS88_1109"}, {"subsystem": "Murein Recycling", "name": "Tripeptide (LalaDgluMdap) transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3PEPTabcpp"]}, "metabolites": {"h2o_c": -1.0, "LalaDgluMdap_p": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "LalaDgluMdap_c": 1.0, "pi_c": 1.0}, "id": "3PEPTabcpp", "gene_reaction_rule": "ECS88_1472 and ECS88_1312 and ECS88_1313 and ECS88_1314 and ECS88_1315"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "LalaDgluMdap (tripeptide) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["3PEPTtex"]}, "metabolites": {"LalaDgluMdap_e": -1.0, "LalaDgluMdap_p": 1.0}, "id": "3PEPTtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "3UMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["3UMPtex"]}, "metabolites": {"3ump_e": -1.0, "3ump_p": 1.0}, "id": "3UMPtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "4-hydroxyphenylacetaldehyde transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["4HOXPACDtex"]}, "metabolites": {"4hoxpacd_p": 1.0, "4hoxpacd_e": -1.0}, "id": "4HOXPACDtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "4-Hydroxy-L-threonine synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["4HTHRS"]}, "metabolites": {"phthr_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0, "4hthr_c": 1.0}, "id": "4HTHRS", "gene_reaction_rule": "ECS88_0004"}, {"subsystem": "Murein Recycling", "name": "Tetrapeptide L,D-carboxypeptidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["4PCP"]}, "metabolites": {"h2o_c": -1.0, "ala__D_c": 1.0, "LalaDgluMdapDala_c": -1.0, "LalaDgluMdap_c": 1.0}, "id": "4PCP", "gene_reaction_rule": "ECS88_1255"}, {"subsystem": "Murein Recycling", "name": "Tetrapeptide L,D-carboxypeptidase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["4PCPpp"]}, "metabolites": {"LalaDgluMdapDala_p": -1.0, "ala__D_p": 1.0, "LalaDgluMdap_p": 1.0, "h2o_p": -1.0}, "id": "4PCPpp", "gene_reaction_rule": ""}, {"subsystem": "Murein Recycling", "name": "Tetrapeptide (LalaDgluMdapDala) transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["4PEPTabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "LalaDgluMdapDala_c": 1.0, "LalaDgluMdapDala_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "4PEPTabcpp", "gene_reaction_rule": "ECS88_1311 and ECS88_1312 and ECS88_1313 and ECS88_1314 and ECS88_1315"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "LalaDgluMdapDala (pentapeptide) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["4PEPTtex"]}, "metabolites": {"LalaDgluMdapDala_p": 1.0, "LalaDgluMdapDala_e": -1.0}, "id": "4PEPTtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "5-Dehydro-D-gluconate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["5DGLCNtex"]}, "metabolites": {"5dglcn_p": 1.0, "5dglcn_e": -1.0}, "id": "5DGLCNtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_2364 or ECS88_1492"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "5'-deoxyadenosine nuclosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["5DOAN"]}, "metabolites": {"h2o_c": -1.0, "ade_c": 1.0, "dad_5_c": -1.0, "5drib_c": 1.0}, "id": "5DOAN", "gene_reaction_rule": "ECS88_0170"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "5-Methylthio-D-ribose transport via proton diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["5MTRtex"]}, "metabolites": {"5mtr_e": -1.0, "5mtr_p": 1.0}, "id": "5MTRtex", "gene_reaction_rule": "ECS88_1492 or ECS88_0957 or ECS88_2364 or ECS88_0276"}, {"subsystem": "Transport, Inner Membrane", "name": "5-Methylthio-D-ribose transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["5MTRtpp"]}, "metabolites": {"5mtr_c": -1.0, "h_c": -1.0, "h_p": 1.0, "5mtr_p": 1.0}, "id": "5MTRtpp", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Arabinose-5-phosphate isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["A5PISO"]}, "metabolites": {"ara5p_c": 1.0, "ru5p__D_c": -1.0}, "id": "A5PISO", "gene_reaction_rule": "ECS88_3580 or ECS88_2971"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase (n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS1"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "ACP_c": -1.0, "amp_c": 1.0, "myrsACP_c": 1.0, "ttdca_c": -1.0}, "id": "AACPS1", "gene_reaction_rule": "ECS88_3131 and ECS88_1108"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase  (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS2"]}, "metabolites": {"atp_c": -1.0, "tdeACP_c": 1.0, "ppi_c": 1.0, "ACP_c": -1.0, "amp_c": 1.0, "ttdcea_c": -1.0}, "id": "AACPS2", "gene_reaction_rule": "ECS88_3131 and ECS88_1108"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase  (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS3"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "ACP_c": -1.0, "amp_c": 1.0, "palmACP_c": 1.0, "hdca_c": -1.0}, "id": "AACPS3", "gene_reaction_rule": "ECS88_3131 and ECS88_1108"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase  (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS4"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "ACP_c": -1.0, "hdcea_c": -1.0, "amp_c": 1.0, "hdeACP_c": 1.0}, "id": "AACPS4", "gene_reaction_rule": "ECS88_3131 and ECS88_1108"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase  (n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS5"]}, "metabolites": {"ocdcea_c": -1.0, "atp_c": -1.0, "octeACP_c": 1.0, "ACP_c": -1.0, "amp_c": 1.0, "ppi_c": 1.0}, "id": "AACPS5", "gene_reaction_rule": "ECS88_3131 and ECS88_1108"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase  (n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS6"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "ACP_c": -1.0, "amp_c": 1.0, "ocdca_c": -1.0, "ocdcaACP_c": 1.0}, "id": "AACPS6", "gene_reaction_rule": "ECS88_3131 and ECS88_1108"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase  (n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS7"]}, "metabolites": {"atp_c": -1.0, "ddca_c": -1.0, "ppi_c": 1.0, "ACP_c": -1.0, "amp_c": 1.0, "ddcaACP_c": 1.0}, "id": "AACPS7", "gene_reaction_rule": "ECS88_3131 and ECS88_1108"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase  (n-C10:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS8"]}, "metabolites": {"dcaACP_c": 1.0, "atp_c": -1.0, "ppi_c": 1.0, "ACP_c": -1.0, "amp_c": 1.0, "dca_c": -1.0}, "id": "AACPS8", "gene_reaction_rule": "ECS88_3131 and ECS88_1108"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase  (n-C8:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS9"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "ACP_c": -1.0, "octa_c": -1.0, "ocACP_c": 1.0, "amp_c": 1.0}, "id": "AACPS9", "gene_reaction_rule": "ECS88_3131 and ECS88_1108"}, {"subsystem": "Methylglyoxal Metabolism", "name": "Aminoacetone:oxygen oxidoreductase(deaminating)(flavin-containing)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACTOOR"]}, "metabolites": {"o2_c": -1.0, "h2o_c": -1.0, "aact_c": -1.0, "h2o2_c": 1.0, "mthgxl_c": 1.0, "nh4_c": 1.0}, "id": "AACTOOR", "gene_reaction_rule": ""}, {"subsystem": "Cell Envelope Biosynthesis", "name": "DTDP-N-4-acetamido-4,6-dideoxy-D-galactose transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AADDGT"]}, "metabolites": {"unagamuf_c": 1.0, "unagamu_c": -1.0, "dtdp_c": 1.0, "h_c": 1.0, "dtdp4aaddg_c": -1.0}, "id": "AADDGT", "gene_reaction_rule": "ECS88_4215"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Alpha-amylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AAMYL"]}, "metabolites": {"14glucan_c": -1.0, "malthx_c": 1.0}, "id": "AAMYL", "gene_reaction_rule": "ECS88_1981"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Alpha-amylase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AAMYLpp"]}, "metabolites": {"14glucan_p": -1.0, "malthx_p": 1.0}, "id": "AAMYLpp", "gene_reaction_rule": "ECS88_3990"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Arbutin 6-phosphate glucohydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AB6PGH"]}, "metabolites": {"g6p_c": 1.0, "h2o_c": -1.0, "hqn_c": 1.0, "arbt6p_c": -1.0}, "id": "AB6PGH", "gene_reaction_rule": "ECS88_3181"}, {"subsystem": "Arginine and Proline Metabolism", "name": "4-aminobutyrate transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ABTA"]}, "metabolites": {"akg_c": -1.0, "glu__L_c": 1.0, "sucsal_c": 1.0, "4abut_c": -1.0}, "id": "ABTA", "gene_reaction_rule": "ECS88_2926"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Aminobutyraldehyde dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ABUTD"]}, "metabolites": {"h2o_c": -1.0, "4abutn_c": -1.0, "4abut_c": 1.0, "h_c": 2.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "ABUTD", "gene_reaction_rule": "ECS88_1538"}, {"subsystem": "Transport, Inner Membrane", "name": "4-aminobutyrate transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ABUTt2pp"]}, "metabolites": {"4abut_p": -1.0, "h_c": 1.0, "h_p": -1.0, "4abut_c": 1.0}, "id": "ABUTt2pp", "gene_reaction_rule": "ECS88_2927"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "4-aminobutyrate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ABUTtex"]}, "metabolites": {"4abut_e": -1.0, "4abut_p": 1.0}, "id": "ABUTtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Acetyl-CoA:acetoacetyl-CoA transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACACCT"]}, "metabolites": {"aacoa_c": 1.0, "acac_c": -1.0, "ac_c": 1.0, "accoa_c": -1.0}, "id": "ACACCT", "gene_reaction_rule": "ECS88_2370 and ECS88_2371"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA C-acetyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT1r"]}, "metabolites": {"aacoa_c": 1.0, "coa_c": 1.0, "accoa_c": -2.0}, "id": "ACACT1r", "gene_reaction_rule": "ECS88_2373 or ECS88_2489 or ECS88_4293"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA C-acyltransferase (butanoyl-CoA) (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT2r"]}, "metabolites": {"btcoa_c": -1.0, "coa_c": 1.0, "accoa_c": -1.0, "3ohcoa_c": 1.0}, "id": "ACACT2r", "gene_reaction_rule": "ECS88_2489 or ECS88_4293"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA C-acyltransferase (hexanoyl-CoA) (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT3r"]}, "metabolites": {"coa_c": 1.0, "accoa_c": -1.0, "3oocoa_c": 1.0, "hxcoa_c": -1.0}, "id": "ACACT3r", "gene_reaction_rule": "ECS88_2489 or ECS88_4293"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA C-acyltransferase (octanoyl-CoA) (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT4r"]}, "metabolites": {"coa_c": 1.0, "3odcoa_c": 1.0, "occoa_c": -1.0, "accoa_c": -1.0}, "id": "ACACT4r", "gene_reaction_rule": "ECS88_2489 or ECS88_4293"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA C-acyltransferase (decanoyl-CoA) (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT5r"]}, "metabolites": {"3oddcoa_c": 1.0, "coa_c": 1.0, "dcacoa_c": -1.0, "accoa_c": -1.0}, "id": "ACACT5r", "gene_reaction_rule": "ECS88_2489 or ECS88_4293"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA C-acyltransferase (dodecanoyl-CoA) (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT6r"]}, "metabolites": {"ddcacoa_c": -1.0, "3otdcoa_c": 1.0, "coa_c": 1.0, "accoa_c": -1.0}, "id": "ACACT6r", "gene_reaction_rule": "ECS88_2489 or ECS88_4293"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA C-acyltransferase (tetradecanoyl-CoA) (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT7r"]}, "metabolites": {"coa_c": 1.0, "tdcoa_c": -1.0, "3ohdcoa_c": 1.0, "accoa_c": -1.0}, "id": "ACACT7r", "gene_reaction_rule": "ECS88_2489 or ECS88_4293"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA acyltransferase (hexadecanoyl-CoA), (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT8r"]}, "metabolites": {"pmtcoa_c": 1.0, "3oodcoa_c": -1.0, "coa_c": -1.0, "accoa_c": 1.0}, "id": "ACACT8r", "gene_reaction_rule": "ECS88_2489 or ECS88_4293"}, {"subsystem": "Transport, Inner Membrane", "name": "Acetoacetate transport via proton symport  (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACt2pp"]}, "metabolites": {"acac_c": 1.0, "acac_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "ACACt2pp", "gene_reaction_rule": "ECS88_2372"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Acetoacetate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACtex"]}, "metabolites": {"acac_p": 1.0, "acac_e": -1.0}, "id": "ACACtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Pyruvate Metabolism", "name": "Acetaldehyde dehydrogenase (acetylating)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACALD"]}, "metabolites": {"nad_c": -1.0, "acald_c": -1.0, "coa_c": -1.0, "h_c": 1.0, "accoa_c": 1.0, "nadh_c": 1.0}, "id": "ACALD", "gene_reaction_rule": "ECS88_1308"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Acetaldehyde transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACALDtex"]}, "metabolites": {"acald_p": 1.0, "acald_e": -1.0}, "id": "ACALDtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "Acetaldehyde reversible transport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACALDtpp"]}, "metabolites": {"acald_c": 1.0, "acald_p": -1.0}, "id": "ACALDtpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Acetyl-CoA:anthranilate acetyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACANTHAT"]}, "metabolites": {"anth_c": -1.0, "coa_c": 1.0, "accoa_c": -1.0, "acanth_c": 1.0}, "id": "ACANTHAT", "gene_reaction_rule": "ECS88_1558"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Adenosyl cobinamide phosphate guanyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACBIPGT"]}, "metabolites": {"adocbip_c": -1.0, "ppi_c": 1.0, "gtp_c": -1.0, "h_c": -1.0, "agdpcbi_c": 1.0}, "id": "ACBIPGT", "gene_reaction_rule": "ECS88_2058"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA carboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACCOAC"]}, "metabolites": {"malcoa_c": 1.0, "adp_c": 1.0, "atp_c": -1.0, "hco3_c": -1.0, "h_c": 1.0, "accoa_c": -1.0, "pi_c": 1.0}, "id": "ACCOAC", "gene_reaction_rule": "ECS88_0196 and ECS88_2463 and ECS88_3631 and ECS88_3632"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Acetate-CoA ligase (ADP-forming)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACCOAL"]}, "metabolites": {"ppcoa_c": 1.0, "atp_c": -1.0, "ppa_c": -1.0, "coa_c": -1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "ACCOAL", "gene_reaction_rule": "ECS88_4562"}, {"subsystem": "Alternate Carbon Metabolism", "name": "N-acetyl-D-galactosamine 1-phosphatase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGAL1PPpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "acgal_p": 1.0, "acgal1p_p": -1.0}, "id": "ACGAL1PPpp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "N-acetyl-D-galactosamine 1-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACGAL1Ptex"]}, "metabolites": {"acgal1p_p": 1.0, "acgal1p_e": -1.0}, "id": "ACGAL1Ptex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "N-acetyl-D-galactosamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACGALtex"]}, "metabolites": {"acgal_p": 1.0, "acgal_e": -1.0}, "id": "ACGALtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Alternate Carbon Metabolism", "name": "N-acetyl-D-glucosamine 1-phosphatase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGAM1PPpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "acgam_p": 1.0, "acgam1p_p": -1.0}, "id": "ACGAM1PPpp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "N-acetyl-D-glucosamine 1-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACGAM1Ptex"]}, "metabolites": {"acgam1p_e": -1.0, "acgam1p_p": 1.0}, "id": "ACGAM1Ptex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Murein Recycling", "name": "N-acetylglucosamine kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGAMK"]}, "metabolites": {"acgam_c": -1.0, "acgam6p_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "ACGAMK", "gene_reaction_rule": "ECS88_1133"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylglucosamine:undecaprenylphosphate N-acetylglucosamine -1-phosphate transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGAMT"]}, "metabolites": {"uacgam_c": -1.0, "ump_c": 1.0, "udcpp_c": -1.0, "unaga_c": 1.0}, "id": "ACGAMT", "gene_reaction_rule": "ECS88_4206"}, {"subsystem": "Transport, Inner Membrane", "name": "N-Acetyl-D-glucosamine transport via PEP:Pyr PTS  (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGAptspp"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "acgam_p": -1.0, "acgam6p_c": 1.0}, "id": "ACGAptspp", "gene_reaction_rule": "(ECS88_2607 and ECS88_1115 and ECS88_2605 and ECS88_2606) or (ECS88_0704 and ECS88_2605 and ECS88_2606)"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "N-Acetyl-D-glucosamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACGAtex"]}, "metabolites": {"acgam_p": 1.0, "acgam_e": -1.0}, "id": "ACGAtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Acetylglutamate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGK"]}, "metabolites": {"acg5p_c": 1.0, "acglu_c": -1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "ACGK", "gene_reaction_rule": "ECS88_4414"}, {"subsystem": "Arginine and Proline Metabolism", "name": "N-acetylglutamate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGS"]}, "metabolites": {"glu__L_c": -1.0, "acglu_c": 1.0, "coa_c": 1.0, "h_c": 1.0, "accoa_c": -1.0}, "id": "ACGS", "gene_reaction_rule": "ECS88_3113"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "2-aceto-2-hydroxybutanoate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACHBS"]}, "metabolites": {"2ahbut_c": 1.0, "pyr_c": -1.0, "2obut_c": -1.0, "co2_c": 1.0, "h_c": -1.0}, "id": "ACHBS", "gene_reaction_rule": "(ECS88_4095 and ECS88_4096) or (ECS88_0081 and ECS88_0082)"}, {"subsystem": "Pyruvate Metabolism", "name": "Acetate kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACKr"]}, "metabolites": {"ac_c": -1.0, "actp_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "ACKr", "gene_reaction_rule": "ECS88_3508 or ECS88_2443 or ECS88_1905"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Acetolactate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACLS"]}, "metabolites": {"pyr_c": -2.0, "co2_c": 1.0, "h_c": -1.0, "alac__S_c": 1.0}, "id": "ACLS", "gene_reaction_rule": "(ECS88_4095 and ECS88_4096) or (ECS88_0081 and ECS88_0082)"}, {"subsystem": "Alternate Carbon Metabolism", "name": "N-acetylmuramate 6-phosphate hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACM6PH"]}, "metabolites": {"acgam6p_c": 1.0, "h2o_c": -1.0, "lac__D_c": 1.0, "acmum6p_c": -1.0}, "id": "ACM6PH", "gene_reaction_rule": "ECS88_2616"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetyl-D-mannosaminuronic acid transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACMAMUT"]}, "metabolites": {"udp_c": 1.0, "unagamu_c": 1.0, "h_c": 1.0, "uacmamu_c": -1.0, "unaga_c": -1.0}, "id": "ACMAMUT", "gene_reaction_rule": "ECS88_4218"}, {"subsystem": "Transport, Inner Membrane", "name": "N-acetyl-D-mannosamine transport via PTS  (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACMANAptspp"]}, "metabolites": {"acmana_p": -1.0, "pep_c": -1.0, "pyr_c": 1.0, "acmanap_c": 1.0}, "id": "ACMANAptspp", "gene_reaction_rule": "ECS88_1869 and ECS88_1870 and ECS88_1871 and ECS88_2605 and ECS88_2606"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "N-acetyl-D-mannosamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACMANAtex"]}, "metabolites": {"acmana_p": 1.0, "acmana_e": -1.0}, "id": "ACMANAtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "N-acetylmuramate transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACMUMptspp"]}, "metabolites": {"pep_c": -1.0, "acmum6p_c": 1.0, "pyr_c": 1.0, "acmum_p": -1.0}, "id": "ACMUMptspp", "gene_reaction_rule": "ECS88_2607 and ECS88_2617 and ECS88_2605 and ECS88_2606"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "N-acetylmuramate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACMUMtex"]}, "metabolites": {"acmum_e": -1.0, "acmum_p": 1.0}, "id": "ACMUMtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "N-acetylneuraminate proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACNAMt2pp"]}, "metabolites": {"h_p": -1.0, "h_c": 1.0, "acnam_p": -1.0, "acnam_c": 1.0}, "id": "ACNAMt2pp", "gene_reaction_rule": "ECS88_3601"}, {"subsystem": "Transport, Outer Membrane", "name": "N-acetylneuraminate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACNAMtex"]}, "metabolites": {"acnam_e": -1.0, "acnam_p": 1.0}, "id": "ACNAMtex", "gene_reaction_rule": "ECS88_4928 or ECS88_0957 or ECS88_2364"}, {"subsystem": "Alternate Carbon Metabolism", "name": "N-Acetylneuraminate lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACNML"]}, "metabolites": {"pyr_c": 1.0, "acmana_c": 1.0, "acnam_c": -1.0}, "id": "ACNML", "gene_reaction_rule": "ECS88_3602"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (butanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOAD1f"]}, "metabolites": {"btcoa_c": -1.0, "b2coa_c": 1.0, "fadh2_c": 1.0, "fad_c": -1.0}, "id": "ACOAD1f", "gene_reaction_rule": "ECS88_0258"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (hexanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOAD2f"]}, "metabolites": {"fadh2_c": 1.0, "fad_c": -1.0, "hxcoa_c": -1.0, "hx2coa_c": 1.0}, "id": "ACOAD2f", "gene_reaction_rule": "ECS88_0258"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (octanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOAD3f"]}, "metabolites": {"oc2coa_c": 1.0, "fadh2_c": 1.0, "occoa_c": -1.0, "fad_c": -1.0}, "id": "ACOAD3f", "gene_reaction_rule": "ECS88_0258"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (decanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOAD4f"]}, "metabolites": {"fadh2_c": 1.0, "dc2coa_c": 1.0, "dcacoa_c": -1.0, "fad_c": -1.0}, "id": "ACOAD4f", "gene_reaction_rule": "ECS88_0258"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (dodecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOAD5f"]}, "metabolites": {"ddcacoa_c": -1.0, "fadh2_c": 1.0, "fad_c": -1.0, "dd2coa_c": 1.0}, "id": "ACOAD5f", "gene_reaction_rule": "ECS88_0258"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (tetradecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOAD6f"]}, "metabolites": {"fadh2_c": 1.0, "tdcoa_c": -1.0, "fad_c": -1.0, "td2coa_c": 1.0}, "id": "ACOAD6f", "gene_reaction_rule": "ECS88_0258"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (hexadecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOAD7f"]}, "metabolites": {"pmtcoa_c": -1.0, "fadh2_c": 1.0, "fad_c": -1.0, "hdd2coa_c": 1.0}, "id": "ACOAD7f", "gene_reaction_rule": "ECS88_0258"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (octadecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOAD8f"]}, "metabolites": {"stcoa_c": -1.0, "fadh2_c": 1.0, "od2coa_c": 1.0, "fad_c": -1.0}, "id": "ACOAD8f", "gene_reaction_rule": "ECS88_0258"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA ACP transacylase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOATA"]}, "metabolites": {"acACP_c": 1.0, "ACP_c": -1.0, "coa_c": 1.0, "accoa_c": -1.0}, "id": "ACOATA", "gene_reaction_rule": "ECS88_1108 and ECS88_1105"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Acetylornithine deacetylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACODA"]}, "metabolites": {"h2o_c": -1.0, "orn_c": 1.0, "ac_c": 1.0, "acorn_c": -1.0}, "id": "ACODA", "gene_reaction_rule": "ECS88_4412"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Arabinose modified core oligosaccharide lipid A transport via ABC system (periplasm to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACOLIPAabctex"]}, "metabolites": {"h2o_c": -1.0, "acolipa_p": -1.0, "adp_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "acolipa_e": 1.0, "pi_c": 1.0}, "id": "ACOLIPAabctex", "gene_reaction_rule": "ECS88_3583 and ECS88_3584 and ECS88_3582 and ECS88_4848 and ECS88_4849"}, {"subsystem": "Unassigned", "name": "Aconitate isomerase (spontaneous)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACONIs"]}, "metabolites": {"acon_T_c": -1.0, "acon_C_c": 1.0}, "id": "ACONIs", "gene_reaction_rule": "s0001"}, {"subsystem": "Unassigned", "name": "Trans-aconitate methyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACONMT"]}, "metabolites": {"amet_c": -1.0, "ahcys_c": 1.0, "acon_T_c": -1.0, "aconm_c": 1.0}, "id": "ACONMT", "gene_reaction_rule": "ECS88_1596"}, {"subsystem": "Citric Acid Cycle", "name": "Aconitase (half-reaction A, Citrate hydro-lyase)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACONTa"]}, "metabolites": {"h2o_c": 1.0, "acon_C_c": 1.0, "cit_c": -1.0}, "id": "ACONTa", "gene_reaction_rule": "ECS88_0127 or ECS88_1416"}, {"subsystem": "Citric Acid Cycle", "name": "Aconitase (half-reaction B, Isocitrate hydro-lyase)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACONTb"]}, "metabolites": {"h2o_c": -1.0, "icit_c": 1.0, "acon_C_c": -1.0}, "id": "ACONTb", "gene_reaction_rule": "ECS88_0127 or ECS88_1416"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Acetylornithine transaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOTA"]}, "metabolites": {"akg_c": -1.0, "glu__L_c": 1.0, "acorn_c": -1.0, 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"id": "ACPS1", "gene_reaction_rule": "ECS88_3878 or ECS88_2736"}, {"subsystem": "Pyruvate Metabolism", "name": "Acetyl-CoA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACS"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "coa_c": -1.0, "amp_c": 1.0, "accoa_c": 1.0, "ac_c": -1.0}, "id": "ACS", "gene_reaction_rule": "ECS88_4562"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "O-Acetyl-L-serine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACSERtex"]}, "metabolites": {"acser_p": 1.0, "acser_e": -1.0}, "id": "ACSERtex", "gene_reaction_rule": "ECS88_1492 or ECS88_2364 or ECS88_0276 or ECS88_0957"}, {"subsystem": "Transport, Inner Membrane", "name": "O-Acetyl-L-serine export via facilitated transport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACSERtpp"]}, "metabolites": {"acser_p": 1.0, "acser_c": -1.0}, "id": "ACSERtpp", "gene_reaction_rule": "ECS88_2752 or ECS88_1615"}, {"subsystem": "Transport, Inner Membrane", "name": "Acetate reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACt2rpp"]}, "metabolites": {"ac_p": -1.0, "ac_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "ACt2rpp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Inner Membrane", "name": "Na+/Acetate symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACt4pp"]}, "metabolites": {"na1_p": -1.0, "ac_p": -1.0, "ac_c": 1.0, "na1_c": 1.0}, "id": "ACt4pp", "gene_reaction_rule": "ECS88_4560"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Acetate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACtex"]}, "metabolites": {"ac_p": 1.0, "ac_e": -1.0}, "id": "ACtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Adenosine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADA"]}, "metabolites": {"h2o_c": -1.0, "nh4_c": 1.0, "adn_c": -1.0, "h_c": -1.0, "ins_c": 1.0}, "id": "ADA", "gene_reaction_rule": "ECS88_1670"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "4-aminobenzoate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADCL"]}, "metabolites": {"pyr_c": 1.0, "4adcho_c": -1.0, "h_c": 1.0, "4abz_c": 1.0}, "id": "ADCL", "gene_reaction_rule": "ECS88_1110"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "4-amino-4-deoxychorismate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADCS"]}, "metabolites": {"glu__L_c": 1.0, "4adcho_c": 1.0, "chor_c": -1.0, "gln__L_c": -1.0}, "id": "ADCS", "gene_reaction_rule": "ECS88_3751 and ECS88_1864"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Adenine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADD"]}, "metabolites": {"h2o_c": -1.0, "nh4_c": 1.0, "ade_c": -1.0, "hxan_c": 1.0, "h_c": -1.0}, "id": "ADD", "gene_reaction_rule": "ECS88_4090"}, {"subsystem": "Transport, Inner Membrane", "name": "Adenine transport via proton symport (reversible) (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ADEt2rpp"]}, "metabolites": {"ade_p": -1.0, "ade_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "ADEt2rpp", "gene_reaction_rule": "ECS88_4070 or ECS88_4089"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Adenine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ADEtex"]}, "metabolites": {"ade_p": 1.0, "ade_e": -1.0}, "id": "ADEtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Adenylate kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ADK1"]}, "metabolites": {"atp_c": -1.0, "adp_c": 2.0, "amp_c": -1.0}, "id": "ADK1", "gene_reaction_rule": "ECS88_0471"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Adentylate kinase (GTP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ADK3"]}, "metabolites": {"gtp_c": -1.0, "gdp_c": 1.0, "amp_c": -1.0, "adp_c": 1.0}, "id": "ADK3", "gene_reaction_rule": "ECS88_0471"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Adentylate kinase (ITP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ADK4"]}, "metabolites": {"itp_c": -1.0, "amp_c": -1.0, "idp_c": 1.0, "adp_c": 1.0}, "id": "ADK4", "gene_reaction_rule": "ECS88_0471"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Adenosylmethionine decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADMDC"]}, "metabolites": {"amet_c": -1.0, "co2_c": 1.0, "h_c": -1.0, "ametam_c": 1.0}, "id": "ADMDC", "gene_reaction_rule": "ECS88_0129"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Adenylate cyclase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADNCYC"]}, "metabolites": {"ppi_c": 1.0, "camp_c": 1.0, "atp_c": -1.0}, "id": "ADNCYC", "gene_reaction_rule": "ECS88_4229"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Adenosine kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADNK1"]}, "metabolites": {"h_c": 1.0, "adn_c": -1.0, "adp_c": 1.0, "atp_c": -1.0, "amp_c": 1.0}, "id": "ADNK1", "gene_reaction_rule": "ECS88_0471"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Adenosine hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADNUC"]}, "metabolites": {"h2o_c": -1.0, "ade_c": 1.0, "adn_c": -1.0, "rib__D_c": 1.0}, "id": "ADNUC", "gene_reaction_rule": "ECS88_0029"}, {"subsystem": "Transport, Inner Membrane", "name": "Adenosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADNt2pp", "ADNt2rpp"]}, "metabolites": {"adn_c": 1.0, "h_c": 1.0, "h_p": -1.0, "adn_p": -1.0}, "id": "ADNt2pp_copy1", "gene_reaction_rule": "ECS88_3247 or ECS88_2587"}, {"subsystem": "Transport, Inner Membrane", "name": "Adenosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ADNt2pp", "ADNt2rpp"]}, "metabolites": {"adn_c": 1.0, "h_c": 1.0, "h_p": -1.0, "adn_p": -1.0}, "id": "ADNt2pp_copy2", "gene_reaction_rule": "ECS88_2595"}, {"subsystem": "Transport, Outer Membrane", "name": "Adenosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ADNtex"]}, "metabolites": {"adn_e": -1.0, "adn_p": 1.0}, "id": "ADNtex", "gene_reaction_rule": "ECS88_0406"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Adenosyl cobinamide kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADOCBIK"]}, "metabolites": {"adocbip_c": 1.0, "adocbi_c": -1.0, "adp_c": 1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "ADOCBIK", "gene_reaction_rule": "ECS88_2058"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Adenosylcobalamin 5'-phosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADOCBLS"]}, "metabolites": {"adocbl_c": 1.0, "gmp_c": 1.0, "h_c": 1.0, "rdmbzi_c": -1.0, "agdpcbi_c": -1.0}, "id": "ADOCBLS", "gene_reaction_rule": "ECS88_2057"}, {"subsystem": "Transport, Inner Membrane", "name": "Adenosylcobalamin transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADOCBLabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "adocbl_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "adocbl_p": -1.0, "pi_c": 1.0}, "id": "ADOCBLabcpp", "gene_reaction_rule": "ECS88_1762 and ECS88_1760 and ECS88_0169"}, {"subsystem": "Transport, Outer Membrane", "name": "Adenosylcobalimin transport via ton system (extermal)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADOCBLtonex"]}, "metabolites": {"adocbl_p": 1.0, "h_c": 1.0, "h_p": -1.0, "adocbl_e": -1.0}, "id": "ADOCBLtonex", "gene_reaction_rule": "ECS88_4425 and (ECS88_1322 and ECS88_3386 and ECS88_3387)"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "ADPribose diphosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADPRDP"]}, "metabolites": {"h2o_c": -1.0, "r5p_c": 1.0, "h_c": 2.0, "adprib_c": -1.0, "amp_c": 1.0}, "id": "ADPRDP", "gene_reaction_rule": "ECS88_3783 or ECS88_3428"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Adenine phosphoribosyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": 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"ADSL2r", "gene_reaction_rule": "ECS88_1146"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Adenylosuccinate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADSS"]}, "metabolites": {"gdp_c": 1.0, "asp__L_c": -1.0, "gtp_c": -1.0, "h_c": 2.0, "pi_c": 1.0, "imp_c": -1.0, "dcamp_c": 1.0}, "id": "ADSS", "gene_reaction_rule": "ECS88_4763"}, {"subsystem": "Alternate Carbon Metabolism", "name": "N-acetylglucosamine-6-phosphate deacetylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGDC"]}, "metabolites": {"ac_c": 1.0, "acgam6p_c": -1.0, "h2o_c": -1.0, "gam6p_c": 1.0}, "id": "AGDC", "gene_reaction_rule": "ECS88_0702"}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tripeptide amidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM3PA"]}, "metabolites": {"LalaDgluMdap_c": 1.0, "h2o_c": -1.0, "anhgm3p_c": -1.0, "anhgm_c": 1.0}, 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["AGM3Pt2pp"]}, "metabolites": {"h_p": -1.0, "h_c": 1.0, "anhgm3p_p": -1.0, "anhgm3p_c": 1.0}, "id": "AGM3Pt2pp", "gene_reaction_rule": "ECS88_0429"}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide amidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM4PA"]}, "metabolites": {"h2o_c": -1.0, "anhgm4p_c": -1.0, "LalaDgluMdapDala_c": 1.0, "anhgm_c": 1.0}, "id": "AGM4PA", "gene_reaction_rule": "ECS88_0112"}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide amidase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM4PApp"]}, "metabolites": {"LalaDgluMdapDala_p": 1.0, "h2o_p": -1.0, "anhgm_p": 1.0, "anhgm4p_p": -1.0}, "id": "AGM4PApp", "gene_reaction_rule": "ECS88_2623 or ECS88_3112 or ECS88_4755"}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide L,D-carboxypeptidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM4PCP"]}, "metabolites": {"ala__D_c": 1.0, "h2o_c": -1.0, "anhgm4p_c": -1.0, "anhgm3p_c": 1.0}, "id": "AGM4PCP", "gene_reaction_rule": "ECS88_1255"}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide L,D-carboxypeptidase (periplasmic)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM4PCPpp"]}, "metabolites": {"h2o_p": -1.0, "anhgm4p_p": -1.0, "anhgm3p_p": 1.0, "ala__D_p": 1.0}, "id": "AGM4PCPpp", "gene_reaction_rule": ""}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide beta -1,4-N-acetylglucosaminidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM4PH"]}, "metabolites": {"acgam_c": 1.0, "anhm4p_c": 1.0, "anhgm4p_c": -1.0, "h2o_c": -1.0}, "id": "AGM4PH", "gene_reaction_rule": "ECS88_1121"}, {"subsystem": "Murein Recycling", "name": "GlcNAc-anhMurNAc tetrapeptide transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM4Pt2pp"]}, "metabolites": {"anhgm4p_c": 1.0, "h_c": 1.0, "h_p": -1.0, "anhgm4p_p": -1.0}, "id": "AGM4Pt2pp", "gene_reaction_rule": "ECS88_0429"}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl beta -1,4-N-acetylglucosaminidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGMH"]}, "metabolites": {"acgam_c": 1.0, "anhm_c": 1.0, "h2o_c": -1.0, "anhgm_c": -1.0}, "id": "AGMH", "gene_reaction_rule": "ECS88_1121"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "ADP-D-glycero-D-manno-heptose epimerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGMHE"]}, "metabolites": {"adphep_DD_c": -1.0, "adphep_LD_c": 1.0}, "id": "AGMHE", "gene_reaction_rule": "ECS88_4035"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Agmatinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGMT"]}, "metabolites": {"ptrc_c": 1.0, "agm_c": -1.0, "urea_c": 1.0, "h2o_c": -1.0}, "id": "AGMT", "gene_reaction_rule": "ECS88_3219"}, {"subsystem": "Murein Recycling", "name": "GlcNAc-anhMurNAc transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGMt2pp"]}, "metabolites": {"h_c": 1.0, "anhgm_p": -1.0, "h_p": -1.0, "anhgm_c": 1.0}, "id": "AGMt2pp", "gene_reaction_rule": "ECS88_0429"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Agmatine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AGMtex"]}, "metabolites": {"agm_p": 1.0, "agm_e": -1.0}, "id": "AGMtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-tetradecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT120"]}, "metabolites": {"1ddecg3p_c": -1.0, "ACP_c": 1.0, "pa120_c": 1.0, "ddcaACP_c": -1.0}, "id": "AGPAT120", "gene_reaction_rule": "ECS88_3406"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-tetradecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT140"]}, "metabolites": {"1tdecg3p_c": -1.0, "pa140_c": 1.0, "ACP_c": 1.0, "myrsACP_c": -1.0}, "id": "AGPAT140", "gene_reaction_rule": "ECS88_3406"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-tetradec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT141"]}, "metabolites": {"tdeACP_c": -1.0, "pa141_c": 1.0, "ACP_c": 1.0, "1tdec7eg3p_c": -1.0}, "id": "AGPAT141", "gene_reaction_rule": "ECS88_3406"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-hexadecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT160"]}, "metabolites": {"pa160_c": 1.0, "ACP_c": 1.0, "1hdecg3p_c": -1.0, "palmACP_c": -1.0}, "id": "AGPAT160", "gene_reaction_rule": "ECS88_3406"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-hexadec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT161"]}, "metabolites": {"pa161_c": 1.0, "1hdec9eg3p_c": -1.0, "ACP_c": 1.0, "hdeACP_c": -1.0}, "id": "AGPAT161", "gene_reaction_rule": "ECS88_3406"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-octadecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT180"]}, "metabolites": {"ocdcaACP_c": -1.0, "ACP_c": 1.0, "1odecg3p_c": -1.0, "pa180_c": 1.0}, "id": "AGPAT180", "gene_reaction_rule": "ECS88_3406"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-octadec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT181"]}, "metabolites": {"1odec11eg3p_c": -1.0, "octeACP_c": -1.0, "ACP_c": 1.0, "pa181_c": 1.0}, "id": "AGPAT181", "gene_reaction_rule": "ECS88_3406"}, {"subsystem": "Arginine and Proline Metabolism", "name": "N-acetyl-g-glutamyl-phosphate reductase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AGPR"]}, "metabolites": {"nadp_c": -1.0, "nadph_c": 1.0, "acg5p_c": 1.0, "acg5sa_c": -1.0, "h_c": 1.0, "pi_c": -1.0}, "id": "AGPR", "gene_reaction_rule": "ECS88_4413"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Silver transport out via proton antiport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGt3"]}, "metabolites": {"ag_e": 1.0, "h_e": -1.0, "h_c": 1.0, "ag_c": -1.0}, "id": "AGt3", "gene_reaction_rule": "ECS88_0609 and ECS88_0610 and ECS88_0611 and ECS88_0612"}, {"subsystem": "Methionine Metabolism", "name": "S-adenosylhomocysteine nucleosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AHCYSNS"]}, "metabolites": {"ade_c": 1.0, "h2o_c": -1.0, "ahcys_c": -1.0, "rhcys_c": 1.0}, "id": "AHCYSNS", "gene_reaction_rule": "ECS88_0170"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylaminoimidazolecarboxamide formyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AICART"]}, "metabolites": {"aicar_c": -1.0, "fprica_c": 1.0, "thf_c": 1.0, "10fthf_c": -1.0}, "id": "AICART", "gene_reaction_rule": "ECS88_4467"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylaminoimidazole carboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AIRC2"]}, "metabolites": {"5caiz_c": 1.0, "atp_c": -1.0, "hco3_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "air_c": -1.0, "pi_c": 1.0}, "id": "AIRC2", "gene_reaction_rule": "ECS88_0521"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylaminoimidazole carboxylase (mutase rxn)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AIRC3"]}, "metabolites": {"5caiz_c": 1.0, "5aizc_c": -1.0}, "id": "AIRC3", "gene_reaction_rule": "ECS88_0522"}, {"subsystem": "Citric Acid Cycle", "name": "2-Oxogluterate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AKGDH"]}, "metabolites": {"akg_c": -1.0, "nadh_c": 1.0, "succoa_c": 1.0, "coa_c": -1.0, "nad_c": -1.0, "co2_c": 1.0}, "id": "AKGDH", "gene_reaction_rule": "ECS88_0125 and ECS88_0751 and ECS88_0752"}, {"subsystem": "Transport, Inner Membrane", "name": "2-oxoglutarate reversible transport via symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AKGt2rpp"]}, "metabolites": {"akg_c": 1.0, "akg_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "AKGt2rpp", "gene_reaction_rule": "ECS88_2762"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Alpha-ketoglutarate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AKGtex"]}, "metabolites": {"akg_p": 1.0, "akg_e": -1.0}, "id": "AKGtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "D-alanyl-D-alanine (DalaDala) transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAALAabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "alaala_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "alaala_c": 1.0}, "id": "ALAALAabcpp", "gene_reaction_rule": "ECS88_3964 and ECS88_3963 and ECS88_3962 and ECS88_3961 and ECS88_3960"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "D-alanine-D-alanine ligase (reversible)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAALAr"]}, "metabolites": {"atp_c": -1.0, "ala__D_c": -2.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "alaala_c": 1.0}, "id": "ALAALAr", "gene_reaction_rule": "ECS88_0375 or ECS88_0095"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-alanyl-D-alanine (DalaDala) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAALAtex"]}, "metabolites": {"alaala_e": -1.0, "alaala_p": 1.0}, "id": "ALAALAtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Murein Recycling", "name": "L-alanyl-gamma-glutamate epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAGLUE"]}, "metabolites": {"LalaDglu_c": -1.0, "LalaLglu_c": 1.0}, "id": "ALAGLUE", "gene_reaction_rule": "ECS88_1467"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "Alanine racemase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAR"]}, "metabolites": {"ala__D_c": 1.0, "ala__L_c": -1.0}, "id": "ALAR", "gene_reaction_rule": "ECS88_1253 or ECS88_4530"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "D-alanine transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALATA_D2"]}, "metabolites": {"ala__D_c": -1.0, "pyr_c": 1.0, "pydx5p_c": -1.0, "pyam5p_c": 1.0}, "id": "ALATA_D2", "gene_reaction_rule": "ECS88_2721 or ECS88_0891"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "L-alanine transaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALATA_L"]}, "metabolites": {"akg_c": -1.0, "pyr_c": 1.0, "ala__L_c": -1.0, "glu__L_c": 1.0}, "id": "ALATA_L", "gene_reaction_rule": "ECS88_2437 or ECS88_2574"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Alanine transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALATA_L2"]}, "metabolites": {"pydx5p_c": -1.0, "pyr_c": 1.0, "ala__L_c": -1.0, "pyam5p_c": 1.0}, "id": "ALATA_L2", "gene_reaction_rule": "ECS88_0891 or ECS88_2721"}, {"subsystem": "tRNA Charging", "name": "Alanyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALATRS"]}, "metabolites": {"trnaala_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "ala__L_c": -1.0, "amp_c": 1.0, "alatrna_c": 1.0}, "id": "ALATRS", "gene_reaction_rule": "ECS88_2960"}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "ala__L_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "ala__L_p": -1.0}, "id": "ALAabcpp", "gene_reaction_rule": "ECS88_3851 and ECS88_3852 and ECS88_3854 and ECS88_3857 and ECS88_3853"}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAt2pp", "ALAt2rpp"]}, "metabolites": {"ala__L_c": 1.0, "h_c": 1.0, "h_p": -1.0, "ala__L_p": -1.0}, "id": "ALAt2pp_copy1", "gene_reaction_rule": "ECS88_4802"}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAt2pp", "ALAt2rpp"]}, "metabolites": {"ala__L_c": 1.0, "h_c": 1.0, "h_p": -1.0, "ala__L_p": -1.0}, "id": "ALAt2pp_copy2", "gene_reaction_rule": ""}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanine transport in via sodium symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAt4pp"]}, "metabolites": {"na1_p": -1.0, "na1_c": 1.0, "ala__L_c": 1.0, "ala__L_p": -1.0}, "id": "ALAt4pp", "gene_reaction_rule": "ECS88_0007"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-alanine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAtex"]}, "metabolites": {"ala__L_e": -1.0, "ala__L_p": 1.0}, "id": "ALAtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Alcohol dehydrogenase (glycerol)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALCD19"]}, "metabolites": {"h_c": -1.0, "nadh_c": -1.0, "glyc_c": 1.0, "nad_c": 1.0, "glyald_c": -1.0}, "id": "ALCD19", "gene_reaction_rule": "ECS88_0356"}, {"subsystem": "Pyruvate Metabolism", "name": "Alcohol dehydrogenase (ethanol)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALCD2x"]}, "metabolites": {"acald_c": 1.0, "nad_c": -1.0, "nadh_c": 1.0, "h_c": 1.0, "etoh_c": -1.0}, "id": "ALCD2x", "gene_reaction_rule": "ECS88_1572 or ECS88_1308 or ECS88_0356"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Aldehyde dehydrogenase (acetaldehyde, NADP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALDD2y"]}, "metabolites": {"h2o_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "acald_c": -1.0, "h_c": 2.0, "ac_c": 1.0}, "id": "ALDD2y", "gene_reaction_rule": "ECS88_4004"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Aldehyde dehydrogenase (propanal, NADP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALDD3y"]}, "metabolites": {"h2o_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "ppa_c": 1.0, "ppal_c": -1.0, "h_c": 2.0}, "id": "ALDD3y", "gene_reaction_rule": "ECS88_4004"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Aldehyde dehydrogenase (butanal, NAD)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALDD4"]}, "metabolites": {"h2o_c": -1.0, "btal_c": -1.0, "but_c": 1.0, "h_c": 2.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "ALDD4", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Allose kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALLK"]}, "metabolites": {"all6p_c": 1.0, "all__D_c": -1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "ALLK", "gene_reaction_rule": "ECS88_4584"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Allose 6-phosphate isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALLPI"]}, "metabolites": {"all6p_c": -1.0, "allul6p_c": 1.0}, "id": "ALLPI", "gene_reaction_rule": "ECS88_4591"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Allantoate amidohydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALLTAMH"]}, "metabolites": {"alltt_c": -1.0, "urdglyc_c": 1.0, "h2o_c": -2.0, "h_c": -2.0, "co2_c": 1.0, "nh4_c": 2.0}, "id": "ALLTAMH", "gene_reaction_rule": "ECS88_0515"}, {"subsystem": "Nitrogen Metabolism", "name": "Allantoinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALLTN"]}, "metabolites": {"alltt_c": 1.0, "h2o_c": -1.0, "h_c": 1.0, "alltn_c": -1.0}, "id": "ALLTN", "gene_reaction_rule": "ECS88_0511"}, {"subsystem": "Transport, Inner Membrane", "name": "Allantoin transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALLTNt2rpp"]}, "metabolites": {"h_p": -1.0, "h_c": 1.0, "alltn_c": 1.0, "alltn_p": -1.0}, "id": "ALLTNt2rpp", "gene_reaction_rule": "ECS88_0510"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Allantoin transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALLTNtex"]}, "metabolites": {"alltn_e": -1.0, "alltn_p": 1.0}, "id": "ALLTNtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Allulose 6-phosphate epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALLULPE"]}, "metabolites": {"allul6p_c": -1.0, "f6p_c": 1.0}, "id": "ALLULPE", "gene_reaction_rule": "ECS88_4585"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Allose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALLtex"]}, "metabolites": {"all__D_p": 1.0, "all__D_e": -1.0}, "id": "ALLtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Unassigned", "name": "Apolipoprotein N-acyltransferase (phosphatidylethanolamine, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALPATE160pp"]}, "metabolites": {"alpp_p": -1.0, "lpp_p": 1.0, "2agpe160_p": 1.0, "pe160_p": -1.0}, "id": "ALPATE160pp", "gene_reaction_rule": "ECS88_0692 and ECS88_1727"}, {"subsystem": "Unassigned", "name": "Apolipoprotein N-acyltransferase (phosphatidylglycerol, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALPATG160pp"]}, "metabolites": {"pg160_p": -1.0, "alpp_p": -1.0, "2agpg160_p": 1.0, "lpp_p": 1.0}, "id": "ALPATG160pp", "gene_reaction_rule": "ECS88_0692 and ECS88_1727"}, {"subsystem": "Methylglyoxal Metabolism", "name": "Aldose reductase (methylglyoxal)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALR2"]}, "metabolites": {"acetol_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "mthgxl_c": -1.0}, "id": "ALR2", "gene_reaction_rule": "ECS88_3392 or ECS88_0222 or ECS88_1834 or ECS88_3383"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Aldose reductase (acetol)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALR4x"]}, "metabolites": {"nadh_c": -1.0, "acetol_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "12ppd__R_c": 1.0}, "id": "ALR4x", "gene_reaction_rule": "ECS88_4401"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Altronate hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALTRH"]}, "metabolites": {"h2o_c": 1.0, "2ddglcn_c": 1.0, "altrn_c": -1.0}, "id": "ALTRH", "gene_reaction_rule": "ECS88_3487"}, {"subsystem": "Murein Recycling", "name": "Anhydrous-N-Acetylmuramyl-tripeptide amidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AM3PA"]}, "metabolites": {"anhm_c": 1.0, "h2o_c": -1.0, "LalaDgluMdap_c": 1.0, "anhm3p_c": -1.0}, "id": "AM3PA", "gene_reaction_rule": "ECS88_0112"}, {"subsystem": "Murein Recycling", "name": "Anhydrous-N-Acetylmuramyl-tetrapeptide amidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AM4PA"]}, "metabolites": {"anhm_c": 1.0, "anhm4p_c": -1.0, "LalaDgluMdapDala_c": 1.0, "h2o_c": -1.0}, "id": "AM4PA", "gene_reaction_rule": "ECS88_0112"}, {"subsystem": "Murein Recycling", "name": "Anhydrous-N-Acetylmuramyl-tetrapeptide L,D-carboxypeptidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AM4PCP"]}, "metabolites": {"anhm4p_c": -1.0, "ala__D_c": 1.0, "h2o_c": -1.0, "anhm3p_c": 1.0}, "id": "AM4PCP", "gene_reaction_rule": "ECS88_1255"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Amylomaltase (maltotriose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMALT1"]}, "metabolites": {"glc__D_c": 1.0, "malt_c": -1.0, "malttr_c": -1.0, "maltttr_c": 1.0}, "id": "AMALT1", "gene_reaction_rule": "ECS88_3805"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Amylomaltase (maltotetraose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMALT2"]}, "metabolites": {"glc__D_c": 1.0, "maltpt_c": 1.0, "malt_c": -1.0, "maltttr_c": -1.0}, "id": "AMALT2", "gene_reaction_rule": "ECS88_3805"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Amylomaltase (maltopentaose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMALT3"]}, "metabolites": {"maltpt_c": -1.0, "glc__D_c": 1.0, "malt_c": -1.0, "malthx_c": 1.0}, "id": "AMALT3", "gene_reaction_rule": "ECS88_3805"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Amylomaltase (maltohexaose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMALT4"]}, "metabolites": {"glc__D_c": 1.0, "malthx_c": -1.0, "malt_c": -1.0, "malthp_c": 1.0}, "id": "AMALT4", "gene_reaction_rule": "ECS88_3805"}, {"subsystem": "Alternate Carbon Metabolism", "name": "N-acetylmannosamine 6-phosphate epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AMANAPEr"]}, "metabolites": {"acgam6p_c": 1.0, "acmanap_c": -1.0}, "id": "AMANAPEr", "gene_reaction_rule": "ECS88_3600"}, {"subsystem": "Alternate Carbon Metabolism", "name": "N-acetyl-D-mannosamine kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMANK"]}, "metabolites": {"acmana_c": -1.0, "acmanap_c": 1.0, "atp_c": -1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "AMANK", "gene_reaction_rule": "ECS88_3599"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Adenosylmethionine-8-amino-7-oxononanoate transaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AMAOTr"]}, "metabolites": {"8aonn_c": -1.0, "amob_c": 1.0, "dann_c": 1.0, "amet_c": -1.0}, "id": "AMAOTr", "gene_reaction_rule": "ECS88_0791"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "S-adenosylmethione:2-demthylmenaquinole methyltransferase (menaquinone 8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMMQLT8"]}, "metabolites": {"amet_c": -1.0, "ahcys_c": 1.0, "2dmmql8_c": -1.0, "mql8_c": 1.0, "h_c": 1.0}, "id": "AMMQLT8", "gene_reaction_rule": "ECS88_4283"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "4-amino-2-methyl-5-phosphomethylpyrimidine synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMPMS2"]}, "metabolites": {"h2o_c": -1.0, "nad_c": -1.0, "4ampm_c": 1.0, "h_c": 3.0, "for_c": 2.0, "air_c": -1.0, "nadh_c": 1.0}, "id": "AMPMS2", "gene_reaction_rule": "ECS88_4455"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "AMP nucleosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMPN"]}, "metabolites": {"r5p_c": 1.0, "ade_c": 1.0, "h2o_c": -1.0, "amp_c": -1.0}, "id": "AMPN", "gene_reaction_rule": "ECS88_2050"}, {"subsystem": "Cysteine Metabolism", "name": "Alanyl aminopeptidase (cys-gly)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMPTASECG"]}, "metabolites": {"cys__L_c": 1.0, "h2o_c": -1.0, "gly_c": 1.0, "cgly_c": -1.0}, "id": "AMPTASECG", "gene_reaction_rule": "ECS88_0272 or ECS88_0960 or ECS88_4847 or ECS88_2699"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Aminopeptidase (pro-gly)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMPTASEPG"]}, "metabolites": {"h2o_c": -1.0, "pro__L_c": 1.0, "gly_c": 1.0, "progly_c": -1.0}, "id": "AMPTASEPG", "gene_reaction_rule": "ECS88_4847 or ECS88_0272 or ECS88_2699 or ECS88_0960"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "AMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AMPtex"]}, "metabolites": {"amp_e": -1.0, "amp_p": 1.0}, "id": "AMPtex", "gene_reaction_rule": "ECS88_2364 or ECS88_0957 or ECS88_1492 or ECS88_0276"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "GlcNAc-anhMurNAc transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ANHGMtex"]}, "metabolites": {"anhgm_e": -1.0, "anhgm_p": 1.0}, "id": "ANHGMtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Murein Recycling", "name": "1,6-anhydrous-N-Acetylmuramate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ANHMK"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "anhm_c": -1.0, "acmum6p_c": 1.0}, "id": "ANHMK", "gene_reaction_rule": "ECS88_1688"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Anthranilate phosphoribosyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ANPRT"]}, "metabolites": {"anth_c": -1.0, "ppi_c": 1.0, "prpp_c": -1.0, "pran_c": 1.0}, "id": "ANPRT", "gene_reaction_rule": "ECS88_1398"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Anthranilate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ANS"]}, "metabolites": {"anth_c": 1.0, "pyr_c": 1.0, "chor_c": -1.0, "h_c": 1.0, "glu__L_c": 1.0, "gln__L_c": -1.0}, "id": "ANS", "gene_reaction_rule": "ECS88_1398 and ECS88_1399"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "L-2-amino-3-oxobutanoate decarboxylation (spontaneous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AOBUTDs"]}, "metabolites": {"h_c": -1.0, "co2_c": 1.0, "2aobut_c": -1.0, "aact_c": 1.0}, "id": "AOBUTDs", "gene_reaction_rule": "s0001"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "8-amino-7-oxononanoate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AOXSr2"]}, "metabolites": {"co2_c": 1.0, "pimACP_c": -1.0, "ACP_c": 1.0, "ala__L_c": -1.0, "8aonn_c": 1.0}, "id": "AOXSr2", "gene_reaction_rule": "ECS88_0793"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Ap4A hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AP4AH"]}, "metabolites": {"ap4a_c": -1.0, "h2o_c": -1.0, "adp_c": 2.0, "h_c": 2.0}, "id": "AP4AH", "gene_reaction_rule": "ECS88_0054"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Ap4A synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AP4AS"]}, "metabolites": {"ap4a_c": 1.0, "ppi_c": 1.0, "atp_c": -2.0, "h_c": -1.0}, "id": "AP4AS", "gene_reaction_rule": "ECS88_3170"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Ap5A hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AP5AH"]}, "metabolites": {"ap5a_c": -1.0, "h2o_c": -1.0, "h_c": 2.0, "atp_c": 1.0, "adp_c": 1.0}, "id": "AP5AH", "gene_reaction_rule": "ECS88_0054"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Aminopropylcadaverine synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["APCS"]}, "metabolites": {"15dap_c": -1.0, "ametam_c": -1.0, "5mta_c": 1.0, "h_c": 1.0, "na15dap_c": 1.0}, "id": "APCS", "gene_reaction_rule": "ECS88_0130"}, {"subsystem": "Glycerophospholipid 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-1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "ARBTNabcpp", "gene_reaction_rule": "ECS88_0164 and ECS88_0162 and ECS88_0163"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Aerobactin Fe-loading reaction (spontaneous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ARBTNexs"]}, "metabolites": {"arbtn_e": -1.0, "arbtn_fe3_e": 1.0, "fe3_e": -1.0}, "id": "ARBTNexs", "gene_reaction_rule": "s0001"}, {"subsystem": "Transport, Outer Membrane", "name": "Aerobactin secretion (to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ARBTNtex"]}, "metabolites": {"arbtn_e": 1.0, "arbtn_p": -1.0, "h_p": -1.0, "h_c": 1.0}, "id": "ARBTNtex", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane", "name": "Aerobactin transport via ton system (extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ARBTNtonex"]}, "metabolites": {"h_p": -1.0, "arbtn_fe3_e": -1.0, "h_c": 1.0, "arbtn_fe3_p": 1.0}, "id": "ARBTNtonex", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Aerobactin secretion (to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ARBTNtpp"]}, "metabolites": {"h_p": -1.0, "arbtn_p": 1.0, "arbtn_c": -1.0, "h_c": 1.0}, "id": "ARBTNtpp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Inner Membrane", "name": "Arbutin transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ARBTptspp"]}, "metabolites": {"arbt_p": -1.0, "pep_c": -1.0, "pyr_c": 1.0, "arbt6p_c": 1.0}, "id": "ARBTptspp", "gene_reaction_rule": "(ECS88_4144 and ECS88_2605 and ECS88_2606) or (ECS88_2978 and ECS88_2605 and ECS88_2606)"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Arbutin transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ARBTtex"]}, "metabolites": {"arbt_p": 1.0, "arbt_e": -1.0}, "id": "ARBTtex", "gene_reaction_rule": "ECS88_2364 or ECS88_1492 or ECS88_0276 or ECS88_0957"}, {"subsystem": "Transport, Inner Membrane", "name": "L-arabinose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ARBabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "arab__L_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "arab__L_c": 1.0}, "id": "ARBabcpp", "gene_reaction_rule": "ECS88_1956 and ECS88_1955 and ECS88_1954"}, {"subsystem": "Transport, Inner Membrane", "name": "L-arabinose transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ARBt2rpp"]}, "metabolites": {"h_p": -1.0, "h_c": 1.0, "arab__L_p": -1.0, "arab__L_c": 1.0}, "id": "ARBt2rpp", "gene_reaction_rule": "ECS88_3138"}, {"subsystem": "Transport, Inner Membrane", "name": "L-arabinose transport via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ARBt3ipp"]}, "metabolites": {"arab__L_p": 1.0, "arab__L_c": -1.0, "h_p": -1.0, "h_c": 1.0}, "id": "ARBt3ipp", "gene_reaction_rule": "ECS88_1604"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-arabinose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ARBtex"]}, "metabolites": {"arab__L_e": -1.0, "arab__L_p": 1.0}, "id": "ARBtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "Arginine/agmatine antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ARGAGMt7pp"]}, "metabolites": {"agm_p": 1.0, "agm_c": -1.0, "arg__L_c": 1.0, "arg__L_p": -1.0}, "id": "ARGAGMt7pp", "gene_reaction_rule": "ECS88_4617"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Arginine decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ARGDC"]}, "metabolites": {"agm_c": 1.0, "co2_c": 1.0, "arg__L_c": -1.0, "h_c": -1.0}, "id": "ARGDC", "gene_reaction_rule": "ECS88_4619"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Arginine decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ARGDCpp"]}, "metabolites": {"co2_p": 1.0, "agm_p": 1.0, "h_p": -1.0, "arg__L_p": -1.0}, "id": "ARGDCpp", "gene_reaction_rule": "ECS88_3221"}, {"subsystem": "Transport, Inner Membrane", "name": "Arginine/ornithine antiporter (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ARGORNt7pp"]}, "metabolites": {"arg__L_c": 1.0, "arg__L_p": -1.0, "orn_c": -1.0, "orn_p": 1.0}, "id": "ARGORNt7pp", "gene_reaction_rule": "ECS88_1650"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Argininosuccinate lyase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": 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"ASNNpp", "gene_reaction_rule": "ECS88_3239"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "Asparagine synthase (glutamine-hydrolysing)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASNS1"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "asp__L_c": -1.0, "asn__L_c": 1.0, "glu__L_c": 1.0, "h_c": 1.0, "amp_c": 1.0, "ppi_c": 1.0, "gln__L_c": -1.0}, "id": "ASNS1", "gene_reaction_rule": "ECS88_0699"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "Asparagine synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASNS2"]}, "metabolites": {"atp_c": -1.0, "asp__L_c": -1.0, "asn__L_c": 1.0, "nh4_c": -1.0, "amp_c": 1.0, "ppi_c": 1.0, "h_c": 1.0}, "id": "ASNS2", "gene_reaction_rule": "ECS88_4166"}, {"subsystem": "tRNA Charging", "name": "Asparaginyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASNTRS"]}, "metabolites": {"trnaasn_c": -1.0, "atp_c": -1.0, 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1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASR"]}, "metabolites": {"aso4_c": -1.0, "aso3_c": 1.0, "gthrd_c": -2.0, "h2o_c": 1.0, "gthox_c": 1.0}, "id": "ASR", "gene_reaction_rule": "ECS88_3908 and ECS88_1078"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Arginine succinyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AST"]}, "metabolites": {"coa_c": 1.0, "succoa_c": -1.0, "sucarg_c": 1.0, "arg__L_c": -1.0, "h_c": 1.0}, "id": "AST", "gene_reaction_rule": "ECS88_1799"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "L-allo-threonine dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ATHRDHr"]}, "metabolites": {"nadp_c": -1.0, "nadph_c": 1.0, "h_c": 1.0, "athr__L_c": -1.0, "2aobut_c": 1.0}, "id": "ATHRDHr", "gene_reaction_rule": "ECS88_1619"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "ATP amine hydrolysis (spontaneous)", "upper_bound": 1000.0, 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1.0, "atp_c": 1.0, "h_p": -4.0, "h_c": 3.0, "adp_c": -1.0, "pi_c": -1.0}, "id": "ATPS4rpp", "gene_reaction_rule": "((ECS88_4158 and ECS88_4159 and ECS88_4160) and (ECS88_4153 and ECS88_4154 and ECS88_4155 and ECS88_4156 and ECS88_4157) and ECS88_4161) or ((ECS88_4158 and ECS88_4159 and ECS88_4160) and (ECS88_4153 and ECS88_4154 and ECS88_4155 and ECS88_4156 and ECS88_4157))"}, {"subsystem": "Transport, Inner Membrane", "name": "Beta-alanine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["BALAt2pp"]}, "metabolites": {"h_p": -1.0, "h_c": 1.0, "ala_B_c": 1.0, "ala_B_p": -1.0}, "id": "BALAt2pp", "gene_reaction_rule": "ECS88_4802"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Beta-alanine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["BALAtex"]}, "metabolites": {"ala_B_e": -1.0, "ala_B_p": 1.0}, "id": "BALAtex", 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{"original_bigg_ids": ["BPNT"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "pap_c": -1.0, "amp_c": 1.0}, "id": "BPNT", "gene_reaction_rule": "ECS88_4808"}, {"subsystem": "Transport, Inner Membrane", "name": "Biotin transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["BTNt2ipp"]}, "metabolites": {"btn_p": -1.0, "btn_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "BTNt2ipp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Biotin transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["BTNtex"]}, "metabolites": {"btn_p": 1.0, "btn_e": -1.0}, "id": "BTNtex", "gene_reaction_rule": "ECS88_2364 or ECS88_1492 or ECS88_0276 or ECS88_0957"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Biotin synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["BTS5"]}, 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(periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CBL1abcpp"]}, "metabolites": {"cbl1_p": -1.0, "h2o_c": -1.0, "atp_c": -1.0, "cbl1_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "CBL1abcpp", "gene_reaction_rule": "ECS88_1762 and ECS88_1760 and ECS88_0169"}, {"subsystem": "Transport, Outer Membrane", "name": "Cob(1)alamin transport via ton system (extermal)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CBL1tonex"]}, "metabolites": {"cbl1_p": 1.0, "cbl1_e": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "CBL1tonex", "gene_reaction_rule": "ECS88_4425 and (ECS88_1322 and ECS88_3386 and ECS88_3387)"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Cob(I)alamin adenosyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CBLAT"]}, "metabolites": {"adocbl_c": 1.0, "cbl1_c": -1.0, "h_c": -1.0, "atp_c": -1.0, "pppi_c": 1.0}, "id": "CBLAT", "gene_reaction_rule": "ECS88_1404"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Carbamate deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CBMD"]}, "metabolites": {"co2_c": 1.0, "h_c": -2.0, "cbm_c": -1.0, "nh4_c": 1.0}, "id": "CBMD", "gene_reaction_rule": "s0001"}, {"subsystem": "Unassigned", "name": "Carbamate kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CBMKr"]}, "metabolites": {"cbp_c": 1.0, "atp_c": -1.0, "h_c": 2.0, "adp_c": 1.0, "co2_c": -1.0, "nh4_c": -1.0}, "id": "CBMKr", "gene_reaction_rule": "ECS88_0520 or ECS88_0331 or ECS88_3153"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Carbamoyl-phosphate synthase (glutamine-hydrolysing)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CBPS"]}, "metabolites": {"cbp_c": 1.0, "atp_c": -2.0, "hco3_c": -1.0, "glu__L_c": 1.0, "h2o_c": -1.0, "h_c": 2.0, "adp_c": 2.0, "pi_c": 1.0, "gln__L_c": -1.0}, "id": "CBPS", "gene_reaction_rule": "ECS88_0032 and ECS88_0033"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "7-cyano-7-carbaguanine synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CCGS"]}, "metabolites": {"preq0_c": 1.0, "h2o_c": 1.0, "pi_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "cdg_c": -1.0, "nh4_c": -1.0}, "id": "CCGS", "gene_reaction_rule": "ECS88_0441"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Cadmium (Cd+2) ABC transporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CD2abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "cd2_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "cd2_p": 1.0}, "id": "CD2abcpp", "gene_reaction_rule": "ECS88_3872"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Cadmium (Cd+2) transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CD2t3pp"]}, "metabolites": {"h_p": -1.0, "cd2_p": 1.0, "cd2_c": -1.0, "h_c": 1.0}, "id": "CD2t3pp", "gene_reaction_rule": "ECS88_4365 or ECS88_0768"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Cadmium (Cd+2) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CD2tex"]}, "metabolites": {"cd2_e": -1.0, "cd2_p": 1.0}, "id": "CD2tex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Cadmium (+2) transport in via permease (no H+)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CD2tpp"]}, "metabolites": {"cd2_p": -1.0, "cd2_c": 1.0}, "id": "CD2tpp", "gene_reaction_rule": "ECS88_3437"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-Diacylglycerol pyrophostatase (n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDAPPA120"]}, "metabolites": {"cdpdddecg_c": -1.0, "h2o_c": -1.0, "h_c": 2.0, "pa120_c": 1.0, "cmp_c": 1.0}, "id": "CDAPPA120", "gene_reaction_rule": "ECS88_4368"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-Diacylglycerol pyrophostatase (n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDAPPA140"]}, "metabolites": {"cdpdtdecg_c": -1.0, "h2o_c": -1.0, "pa140_c": 1.0, "h_c": 2.0, "cmp_c": 1.0}, "id": "CDAPPA140", "gene_reaction_rule": "ECS88_4368"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-Diacylglycerol pyrophostatase (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDAPPA141"]}, "metabolites": {"pa141_c": 1.0, "h2o_c": -1.0, "cdpdtdec7eg_c": -1.0, "h_c": 2.0, "cmp_c": 1.0}, "id": "CDAPPA141", "gene_reaction_rule": "ECS88_4368"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-Diacylglycerol pyrophostatase (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDAPPA160"]}, "metabolites": {"pa160_c": 1.0, "h2o_c": -1.0, "cmp_c": 1.0, "h_c": 2.0, "cdpdhdecg_c": -1.0}, "id": "CDAPPA160", "gene_reaction_rule": "ECS88_4368"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-Diacylglycerol pyrophostatase (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDAPPA161"]}, "metabolites": {"pa161_c": 1.0, "h2o_c": -1.0, "cmp_c": 1.0, "h_c": 2.0, "cdpdhdec9eg_c": -1.0}, "id": "CDAPPA161", "gene_reaction_rule": "ECS88_4368"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-Diacylglycerol pyrophostatase (n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDAPPA180"]}, "metabolites": {"h_c": 2.0, "cdpdodecg_c": -1.0, "cmp_c": 1.0, "h2o_c": -1.0, "pa180_c": 1.0}, "id": "CDAPPA180", "gene_reaction_rule": "ECS88_4368"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-Diacylglycerol pyrophostatase (n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDAPPA181"]}, "metabolites": {"pa181_c": 1.0, "h2o_c": -1.0, "h_c": 2.0, "cdpdodec11eg_c": -1.0, "cmp_c": 1.0}, "id": "CDAPPA181", "gene_reaction_rule": "ECS88_4368"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "7-cyano-7-deazaguanine reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDGR"]}, "metabolites": {"preq1_c": 1.0, "preq0_c": -1.0, "nadp_c": 2.0, "nadph_c": -2.0, "h_c": -3.0}, "id": "CDGR", "gene_reaction_rule": "ECS88_3063"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "7-deaza-7-carboxyguanine synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDGS"]}, "metabolites": {"cdg_c": 1.0, "cph4_c": -1.0, "h_c": -1.0, "nh4_c": 1.0}, "id": "CDGS", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDPMEK"]}, "metabolites": {"2p4c2me_c": 1.0, "4c2me_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "CDPMEK", "gene_reaction_rule": "ECS88_1276"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cyclopropane fatty acid synthase (Phosphatidylethanolamine, n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CFAS160E"]}, "metabolites": {"ahcys_c": 2.0, "cpe160_c": 1.0, "pe161_c": -1.0, "h_c": 2.0, "amet_c": -2.0}, "id": "CFAS160E", "gene_reaction_rule": "ECS88_1710"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cyclopropane fatty acid synthase (Phosphatidylglycerol, n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CFAS160G"]}, "metabolites": {"cpg160_c": 1.0, "pg161_c": -1.0, "ahcys_c": 2.0, "h_c": 2.0, "amet_c": -2.0}, "id": "CFAS160G", "gene_reaction_rule": "ECS88_1710"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cyclopropane fatty acid synthase (Phosphatidylethanolamine, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CFAS180E"]}, "metabolites": {"cpe180_c": 1.0, "pe181_c": -1.0, "ahcys_c": 2.0, "h_c": 2.0, "amet_c": -2.0}, "id": "CFAS180E", "gene_reaction_rule": "ECS88_1710"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cyclopropane fatty acid synthase (Phosphatidylglycerol, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CFAS180G"]}, "metabolites": {"ahcys_c": 2.0, "cpg180_c": 1.0, "pg181_c": -1.0, "h_c": 2.0, "amet_c": -2.0}, "id": "CFAS180G", "gene_reaction_rule": "ECS88_1710"}, {"subsystem": "Transport, Inner Membrane", "name": "L-Cysteinylglycine (Cys-Gly) transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CGLYabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "cgly_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "cgly_c": 1.0}, "id": "CGLYabcpp", "gene_reaction_rule": "ECS88_3964 and ECS88_3963 and ECS88_3962 and ECS88_3961 and ECS88_3960"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-Cysteinylglycine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CGLYtex"]}, "metabolites": {"cgly_e": -1.0, "cgly_p": 1.0}, "id": "CGLYtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "Choline transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHLabcpp"]}, "metabolites": {"h2o_c": -1.0, "chol_p": -1.0, "atp_c": -1.0, "chol_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "CHLabcpp", "gene_reaction_rule": "ECS88_2272 and ECS88_2273 and ECS88_2274 and ECS88_2275"}, {"subsystem": "Transport, Inner Membrane", "name": "Choline transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHLt2pp"]}, "metabolites": {"chol_c": 1.0, "chol_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "CHLt2pp", "gene_reaction_rule": "ECS88_0322"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Choline transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CHLtex"]}, "metabolites": {"chol_p": 1.0, "chol_e": -1.0}, "id": "CHLtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Unassigned", "name": "Choline dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHOLD"]}, "metabolites": {"chol_c": -1.0, "nadh_c": 1.0, "betald_c": 1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "CHOLD", "gene_reaction_rule": "ECS88_0319"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Chorismate mutase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHORM"]}, "metabolites": {"chor_c": -1.0, "pphn_c": 1.0}, "id": "CHORM", "gene_reaction_rule": "ECS88_2785 or ECS88_2786"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Chorismate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHORS"]}, "metabolites": {"chor_c": 1.0, "pi_c": 1.0, "3psme_c": -1.0}, "id": "CHORS", "gene_reaction_rule": "ECS88_2477"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Chorismate pyruvate lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHRPL"]}, "metabolites": {"4hbz_c": 1.0, "pyr_c": 1.0, "chor_c": -1.0}, "id": "CHRPL", "gene_reaction_rule": "ECS88_4512"}, {"subsystem": "Transport, Inner Membrane", "name": "Chitobiose transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHTBSptspp"]}, "metabolites": {"chtbs_p": -1.0, "pep_c": -1.0, "pyr_c": 1.0, "chtbs6p_c": 1.0}, "id": "CHTBSptspp", "gene_reaction_rule": "ECS88_2606"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Chitobiose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CHTBStex"]}, "metabolites": {"chtbs_p": 1.0, "chtbs_e": -1.0}, "id": "CHTBStex", "gene_reaction_rule": "ECS88_2364 or ECS88_0957 or ECS88_1492 or ECS88_0276"}, {"subsystem": "Citric Acid Cycle", "name": "Citrate lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CITL"]}, "metabolites": {"ac_c": 1.0, "oaa_c": 1.0, "cit_c": -1.0}, "id": "CITL", "gene_reaction_rule": "(ECS88_0656 and ECS88_0657 and ECS88_0658) and ECS88_0655"}, {"subsystem": "Transport, Inner Membrane", "name": "Citrate transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CITt3pp"]}, "metabolites": {"cit_p": 1.0, "h_c": 1.0, "h_p": -1.0, "cit_c": -1.0}, "id": "CITt3pp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Inner Membrane", "name": "Citrate transport via succinate antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CITt7pp"]}, "metabolites": {"succ_p": 1.0, "succ_c": -1.0, "cit_p": -1.0, "cit_c": 1.0}, "id": "CITt7pp", "gene_reaction_rule": "ECS88_0653"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Citrate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CITtex"]}, "metabolites": {"cit_e": -1.0, "cit_p": 1.0}, "id": "CITtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Cold lipid A transport via ABC system (periplasm to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLIPAabctex"]}, "metabolites": {"lipa_cold_e": 1.0, "atp_c": -1.0, "h2o_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "lipa_cold_p": -1.0, "pi_c": 1.0}, "id": "CLIPAabctex", "gene_reaction_rule": "ECS88_3583 and ECS88_3584 and ECS88_3582 and ECS88_4848 and ECS88_4849"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH120pp"]}, "metabolites": {"h_p": 1.0, "h2o_p": -1.0, "pg120_p": 1.0, "pa120_p": 1.0, "clpn120_p": -1.0}, "id": "CLPNH120pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH140pp"]}, "metabolites": {"pa140_p": 1.0, "h2o_p": -1.0, "pg140_p": 1.0, "clpn140_p": -1.0, "h_p": 1.0}, "id": "CLPNH140pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH141pp"]}, "metabolites": {"pa141_p": 1.0, "pg141_p": 1.0, "clpn141_p": -1.0, "h_p": 1.0, "h2o_p": -1.0}, "id": "CLPNH141pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH160pp"]}, "metabolites": {"pg160_p": 1.0, "h2o_p": -1.0, "clpn160_p": -1.0, "pa160_p": 1.0, "h_p": 1.0}, "id": "CLPNH160pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH161pp"]}, "metabolites": {"clpn161_p": -1.0, "h2o_p": -1.0, "pa161_p": 1.0, "h_p": 1.0, "pg161_p": 1.0}, "id": "CLPNH161pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH180pp"]}, "metabolites": {"clpn180_p": -1.0, "h2o_p": -1.0, "pa180_p": 1.0, "h_p": 1.0, "pg180_p": 1.0}, "id": "CLPNH180pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH181pp"]}, "metabolites": {"h2o_p": -1.0, "pg181_p": 1.0, "clpn181_p": -1.0, "h_p": 1.0, "pa181_p": 1.0}, "id": "CLPNH181pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin synthase (periplasmic, n-C12:0)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CLPNS120pp"]}, "metabolites": {"pg120_p": -2.0, "clpn120_p": 1.0, "glyc_p": 1.0}, "id": "CLPNS120pp", "gene_reaction_rule": "ECS88_0807 or ECS88_1317"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin synthase (periplasmic, n-C14:0)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CLPNS140pp"]}, "metabolites": {"clpn140_p": 1.0, "pg140_p": -2.0, "glyc_p": 1.0}, "id": "CLPNS140pp", "gene_reaction_rule": "ECS88_1317 or ECS88_0807"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin synthase (periplasmic, n-C14:1)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CLPNS141pp"]}, "metabolites": {"clpn141_p": 1.0, "pg141_p": -2.0, "glyc_p": 1.0}, "id": "CLPNS141pp", "gene_reaction_rule": "ECS88_0807 or ECS88_1317"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin synthase (periplasmic, n-C16:0)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CLPNS160pp"]}, "metabolites": {"pg160_p": -2.0, "clpn160_p": 1.0, "glyc_p": 1.0}, "id": "CLPNS160pp", "gene_reaction_rule": "ECS88_0807 or ECS88_1317"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin synthase (periplasmic, n-C16:1)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CLPNS161pp"]}, "metabolites": {"pg161_p": -2.0, "clpn161_p": 1.0, "glyc_p": 1.0}, "id": "CLPNS161pp", "gene_reaction_rule": "ECS88_1317 or ECS88_0807"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin synthase (periplasmic, n-C18:0)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CLPNS180pp"]}, "metabolites": {"clpn180_p": 1.0, "pg180_p": -2.0, "glyc_p": 1.0}, "id": "CLPNS180pp", "gene_reaction_rule": "ECS88_0807 or ECS88_1317"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin synthase (periplasmic, n-C18:1)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CLPNS181pp"]}, "metabolites": {"clpn181_p": 1.0, "glyc_p": 1.0, "pg181_p": -2.0}, "id": "CLPNS181pp", "gene_reaction_rule": "ECS88_0807 or ECS88_1317"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Chloride transport out via proton antiport (2:1) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLt3_2pp"]}, "metabolites": {"cl_p": -2.0, "h_c": -1.0, "h_p": 1.0, "cl_c": 2.0}, "id": "CLt3_2pp", "gene_reaction_rule": "ECS88_0166 or ECS88_1637"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Chloride (Cl-1) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CLtex"]}, "metabolites": {"cl_e": -1.0, "cl_p": 1.0}, "id": "CLtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "CMP nucleosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CMPN"]}, "metabolites": {"h2o_c": -1.0, "csn_c": 1.0, "r5p_c": 1.0, "cmp_c": -1.0}, "id": "CMPN", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "CMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CMPtex"]}, "metabolites": {"cmp_e": -1.0, "cmp_p": 1.0}, "id": "CMPtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Chloramphenicol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CMtex"]}, "metabolites": {"cm_e": -1.0, "cm_p": 1.0}, "id": "CMtex", "gene_reaction_rule": "ECS88_1492 or ECS88_2364 or ECS88_0957 or ECS88_0276"}, {"subsystem": "Transport, Outer Membrane", "name": "Chloramphenicol transport via TolC system", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CMtpp"]}, "metabolites": {"cm_e": 1.0, "cm_p": -1.0, "h_p": -1.0, "h_c": 1.0}, "id": "CMtpp", "gene_reaction_rule": "ECS88_0460 and ECS88_2649 and ECS88_3429"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "CO2 transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CO2tex"]}, "metabolites": {"co2_p": 1.0, "co2_e": -1.0}, "id": "CO2tex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "CO2 transporter via diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CO2tpp"]}, "metabolites": {"co2_p": -1.0, "co2_c": 1.0}, "id": "CO2tpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Cobalt (Co+2) ABC transporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["COBALT2abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "cobalt2_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "cobalt2_p": 1.0}, "id": "COBALT2abcpp", "gene_reaction_rule": "ECS88_3872"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Cobalt (Co+2) transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["COBALT2t3pp"]}, "metabolites": {"h_p": -1.0, "cobalt2_p": 1.0, "cobalt2_c": -1.0, "h_c": 1.0}, "id": "COBALT2t3pp", "gene_reaction_rule": "ECS88_0768 or ECS88_4365"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Cobalt (Co+2) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["COBALT2tex"]}, "metabolites": {"cobalt2_e": -1.0, "cobalt2_p": 1.0}, "id": "COBALT2tex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Cobalt transport in via permease (no H+)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["COBALT2tpp"]}, "metabolites": {"cobalt2_p": -1.0, "cobalt2_c": 1.0}, "id": "COBALT2tpp", "gene_reaction_rule": "ECS88_3437 or ECS88_4242"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Lipid A core kinase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["COLIPAKpp"]}, "metabolites": {"udcpdp_p": -1.0, "colipa_p": -1.0, "udcpp_p": 1.0, "colipap_p": 1.0}, "id": "COLIPAKpp", "gene_reaction_rule": "ECS88_2323"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Core oligosaccharide lipid A diphosphate transport via ABC system (periplasm to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["COLIPAPabctex"]}, "metabolites": {"h2o_c": -1.0, "colipap_e": 1.0, "adp_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "colipap_p": -1.0, "pi_c": 1.0}, "id": "COLIPAPabctex", "gene_reaction_rule": "ECS88_3583 and ECS88_3584 and ECS88_3582 and ECS88_4848 and ECS88_4849"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Core oligosaccharide lipid A transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["COLIPAabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "colipa_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "colipa_c": -1.0, "pi_c": 1.0}, "id": "COLIPAabcpp", "gene_reaction_rule": "ECS88_0942"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Core oligosaccharide lipid A transport via ABC system (periplasm to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["COLIPAabctex"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "colipa_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "colipa_e": 1.0}, "id": "COLIPAabctex", "gene_reaction_rule": "ECS88_3583 and ECS88_3584 and ECS88_3582 and ECS88_4848 and ECS88_4849"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Coprogen(Fe(III)) 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unloaded secretion (extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CPGNUtex"]}, "metabolites": {"cpgn_un_p": -1.0, "cpgn_un_e": 1.0, "h_p": -1.0, "h_c": 1.0}, "id": "CPGNUtex", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Coprogen unloaded secretion", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CPGNUtpp"]}, "metabolites": {"cpgn_un_p": 1.0, "cpgn_un_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "CPGNUtpp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Inner Membrane", "name": "Coprogen transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CPGNabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "cpgn_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "cpgn_p": -1.0}, "id": "CPGNabcpp", "gene_reaction_rule": "ECS88_0164 and ECS88_0162 and ECS88_0163"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Coprogen Fe-loading reaction (spontaneaous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CPGNexs"]}, "metabolites": {"cpgn_e": 1.0, "cpgn_un_e": -1.0, "fe3_e": -1.0}, "id": "CPGNexs", "gene_reaction_rule": "s0001"}, {"subsystem": "Transport, Outer Membrane", "name": "Coprogen transport via ton system (extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CPGNtonex"]}, "metabolites": {"cpgn_e": -1.0, "h_c": 1.0, "h_p": -1.0, "cpgn_p": 1.0}, "id": "CPGNtonex", "gene_reaction_rule": "ECS88_1116 and (ECS88_1322 and ECS88_3386 and ECS88_3387)"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "6-carboxy-5,6,7,8-tetrahydropterin synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CPH4S"]}, "metabolites": {"h2o_c": -1.0, "acald_c": 1.0, "ahdt_c": -1.0, "h_c": 1.0, "pppi_c": 1.0, "cph4_c": 1.0}, "id": "CPH4S", "gene_reaction_rule": "ECS88_3029"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Cyclic pyranopterin monophosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CPMPS"]}, "metabolites": {"ppi_c": 1.0, "gtp_c": -1.0, "h2o_c": -1.0, "cpmp_c": 1.0}, "id": "CPMPS", "gene_reaction_rule": "ECS88_0798 and ECS88_0800"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Coproporphyrinogen oxidase (O2 required)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CPPPGO"]}, "metabolites": {"o2_c": -1.0, "h2o_c": 2.0, "pppg9_c": 1.0, "cpppg3_c": -1.0, "h_c": -2.0, "co2_c": 2.0}, "id": "CPPPGO", "gene_reaction_rule": "ECS88_2624"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Oxygen Independent coproporphyrinogen-III oxidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CPPPGO2"]}, "metabolites": {"pppg9_c": 1.0, "dad_5_c": 2.0, "cpppg3_c": -1.0, "met__L_c": 2.0, "amet_c": -2.0, "co2_c": 2.0}, "id": "CPPPGO2", "gene_reaction_rule": "ECS88_4316"}, {"subsystem": "Oxidative Phosphorylation", "name": "Gamma-butyrobetainyl-CoA: carnitine CoA transferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CRNBTCT"]}, "metabolites": {"crn_c": -1.0, "gbbtn_c": 1.0, "crncoa_c": 1.0, "bbtcoa_c": -1.0}, "id": "CRNBTCT", "gene_reaction_rule": "ECS88_0041"}, {"subsystem": "Oxidative Phosphorylation", "name": "Carnitine-CoA Ligase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CRNCAL2"]}, "metabolites": {"crn_c": -1.0, "crncoa_c": 1.0, "atp_c": -1.0, "coa_c": -1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "CRNCAL2", "gene_reaction_rule": "ECS88_0040"}, {"subsystem": "Oxidative Phosphorylation", "name": "Carnitine-CoA racemase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CRNCAR"]}, "metabolites": {"crnDcoa_c": 1.0, "crncoa_c": -1.0}, "id": "CRNCAR", "gene_reaction_rule": "ECS88_0039"}, {"subsystem": "Oxidative Phosphorylation", "name": "Crotonobetainyl-CoA: carnitine CoA transferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CRNCBCT"]}, "metabolites": {"crn_c": -1.0, "ctbtcoa_c": -1.0, "crncoa_c": 1.0, "ctbt_c": 1.0}, "id": "CRNCBCT", "gene_reaction_rule": "ECS88_0041"}, {"subsystem": "Oxidative Phosphorylation", "name": "Carnityl-CoA dehydratse", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CRNCDH"]}, "metabolites": {"ctbtcoa_c": 1.0, "h2o_c": 1.0, "crncoa_c": -1.0}, "id": "CRNCDH", "gene_reaction_rule": "ECS88_0039"}, {"subsystem": "Oxidative Phosphorylation", "name": "D-Carnitine-CoA Ligase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CRNDCAL2"]}, "metabolites": {"atp_c": -1.0, "crnDcoa_c": 1.0, "coa_c": -1.0, "adp_c": 1.0, "pi_c": 1.0, "crn__D_c": -1.0}, "id": "CRNDCAL2", "gene_reaction_rule": "ECS88_0040"}, {"subsystem": 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["CTBTt2rpp"]}, "metabolites": {"ctbt_p": -1.0, "h_c": 1.0, "h_p": -1.0, "ctbt_c": 1.0}, "id": "CTBTt2rpp", "gene_reaction_rule": "ECS88_4612"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-cis-2-trans-enoyl-CoA isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CTECOAI6", "TDECOAI"]}, "metabolites": {"tdecoa_c": -1.0, "td2coa_c": 1.0}, "id": "CTECOAI6_copy1", "gene_reaction_rule": "ECS88_4294"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-cis-2-trans-enoyl-CoA isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CTECOAI7", "HDCOAI"]}, "metabolites": {"hdcoa_c": -1.0, "hdd2coa_c": 1.0}, "id": "CTECOAI7_copy1", "gene_reaction_rule": "ECS88_4294"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-cis-2-trans-enoyl-CoA isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CTECOAI8", "ODECOAI"]}, "metabolites": {"od2coa_c": 1.0, "odecoa_c": -1.0}, "id": "CTECOAI8_copy1", "gene_reaction_rule": "ECS88_4294"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "CTP synthase (glutamine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CTPS2"]}, "metabolites": {"utp_c": -1.0, "atp_c": -1.0, "glu__L_c": 1.0, "h2o_c": -1.0, "h_c": 2.0, "adp_c": 1.0, "ctp_c": 1.0, "pi_c": 1.0, "gln__L_c": -1.0}, "id": "CTPS2", "gene_reaction_rule": "ECS88_3048"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Cuprous Oxidase (Cu+1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CU1Opp"]}, "metabolites": {"h2o_p": 2.0, "cu2_p": 4.0, "o2_p": -1.0, "cu_p": -4.0, "h_p": -4.0}, "id": "CU1Opp", "gene_reaction_rule": "ECS88_0132"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Copper (Cu +1) ABC transporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CU1abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "cu_c": -1.0, "cu_p": 1.0, "adp_c": 1.0, "pi_c": 1.0, "h_c": 1.0}, "id": "CU1abcpp", "gene_reaction_rule": "ECS88_0485"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Copper (Cu+2) ABC transporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CU2abcpp"]}, "metabolites": {"cu2_c": -1.0, "h2o_c": -1.0, "atp_c": -1.0, "cu2_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "CU2abcpp", "gene_reaction_rule": "ECS88_3872"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Copper (Cu+2) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CU2tex"]}, "metabolites": {"cu2_p": 1.0, "cu2_e": -1.0}, "id": "CU2tex", "gene_reaction_rule": "ECS88_2364 or ECS88_0276 or ECS88_0957 or ECS88_1492"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Copper transport in via permease (no H+)", "upper_bound": 1000.0, "lower_bound": 0.0, 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"metabolites": {"cyan_c": -1.0, "so3_c": 1.0, "tsul_c": -1.0, "h_c": 1.0, "tcynt_c": 1.0}, "id": "CYANST", "gene_reaction_rule": "ECS88_3814"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Cyanide sulfurtransferase (periplasmic)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYANSTpp"]}, "metabolites": {"so3_p": 1.0, "tcynt_p": 1.0, "cyan_p": -1.0, "h_p": 1.0, "tsul_p": -1.0}, "id": "CYANSTpp", "gene_reaction_rule": "ECS88_1449"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Cyanide transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CYANtex"]}, "metabolites": {"cyan_e": -1.0, "cyan_p": 1.0}, "id": "CYANtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Cyanate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CYNTtex"]}, "metabolites": {"cynt_p": 1.0, "cynt_e": -1.0}, "id": "CYNTtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Cysteine Metabolism", "name": "D-cysteine desulfhydrase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYSDDS"]}, "metabolites": {"cys__D_c": -1.0, "pyr_c": 1.0, "h2o_c": -1.0, "h2s_c": 1.0, "nh4_c": 1.0}, "id": "CYSDDS", "gene_reaction_rule": "ECS88_1973"}, {"subsystem": "Cysteine Metabolism", "name": "Cysteine Desulfhydrase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYSDS"]}, "metabolites": {"cys__L_c": -1.0, "pyr_c": 1.0, "h2o_c": -1.0, "h2s_c": 1.0, "nh4_c": 1.0}, "id": "CYSDS", "gene_reaction_rule": "ECS88_4131 or ECS88_3388"}, {"subsystem": "Transport, Inner Membrane", "name": "D-cysteine uptake via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYSDabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "cys__D_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "cys__D_c": 1.0, "pi_c": 1.0}, "id": "CYSDabcpp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-cysteine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CYSDtex"]}, "metabolites": {"cys__D_p": 1.0, "cys__D_e": -1.0}, "id": "CYSDtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Cysteine Metabolism", "name": "Cysteine synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYSS"]}, "metabolites": {"cys__L_c": 1.0, "ac_c": 1.0, "acser_c": -1.0, "h_c": 1.0, "h2s_c": -1.0}, "id": "CYSS", "gene_reaction_rule": "ECS88_2604 or ECS88_2610"}, {"subsystem": "Cysteine Metabolism", "name": "L-cysteine sulfinic acid desulfurase", "upper_bound": 1000.0, "lower_bound": 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{"original_bigg_ids": ["CYSabc2pp"]}, "metabolites": {"cys__L_c": -1.0, "h2o_c": -1.0, "atp_c": -1.0, "cys__L_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "CYSabc2pp", "gene_reaction_rule": "ECS88_0915 and ECS88_0916"}, {"subsystem": "Transport, Inner Membrane", "name": "L-cysteine uptake via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYSabcpp"]}, "metabolites": {"cys__L_c": 1.0, "h2o_c": -1.0, "atp_c": -1.0, "cys__L_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "CYSabcpp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-cysteine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CYStex"]}, "metabolites": {"cys__L_p": 1.0, "cys__L_e": -1.0}, "id": "CYStex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": 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(ECS88_0756 and ECS88_0757)"}, {"subsystem": "Oxidative Phosphorylation", "name": "Cytochrome oxidase bo3 (ubiquinol-8: 4 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYTBO3_4pp"]}, "metabolites": {"o2_c": -0.5, "h2o_c": 1.0, "h_p": 4.0, "q8h2_c": -1.0, "h_c": -4.0, "q8_c": 1.0}, "id": "CYTBO3_4pp", "gene_reaction_rule": "ECS88_0425 and ECS88_0426 and ECS88_0427 and ECS88_0428"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Cytidine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYTD"]}, "metabolites": {"cytd_c": -1.0, "uri_c": 1.0, "h2o_c": -1.0, "h_c": -1.0, "nh4_c": 1.0}, "id": "CYTD", "gene_reaction_rule": "ECS88_2289"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Cytidine hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYTDH"]}, "metabolites": {"cytd_c": -1.0, "h2o_c": -1.0, "csn_c": 1.0, "rib__D_c": 1.0}, "id": "CYTDH", 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"gene_reaction_rule": "ECS88_3247 or ECS88_2587"}, {"subsystem": "Transport, Outer Membrane", "name": "Deoxyadenosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DADNtex"]}, "metabolites": {"dad_2_p": 1.0, "dad_2_e": -1.0}, "id": "DADNtex", "gene_reaction_rule": "ECS88_0406"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Diacylglycerol kinase (n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAGK120"]}, "metabolites": {"pa120_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "12dgr120_c": -1.0}, "id": "DAGK120", "gene_reaction_rule": "ECS88_4515"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Diacylglycerol kinase (n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAGK140"]}, "metabolites": {"adp_c": 1.0, "pa140_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "12dgr140_c": -1.0}, "id": "DAGK140", "gene_reaction_rule": "ECS88_4515"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Diacylglycerol kinase (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAGK141"]}, "metabolites": {"pa141_c": 1.0, "12dgr141_c": -1.0, "adp_c": 1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "DAGK141", "gene_reaction_rule": "ECS88_4515"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Diacylglycerol kinase (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAGK160"]}, "metabolites": {"pa160_c": 1.0, "12dgr160_c": -1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "DAGK160", "gene_reaction_rule": "ECS88_4515"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Diacylglycerol kinase (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAGK161"]}, "metabolites": {"pa161_c": 1.0, "12dgr161_c": -1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "DAGK161", "gene_reaction_rule": "ECS88_4515"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Diacylglycerol kinase (n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAGK180"]}, "metabolites": {"adp_c": 1.0, "12dgr180_c": -1.0, "h_c": 1.0, "atp_c": -1.0, "pa180_c": 1.0}, "id": "DAGK180", "gene_reaction_rule": "ECS88_4515"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Diacylglycerol kinase (n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAGK181"]}, "metabolites": {"12dgr181_c": -1.0, "pa181_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "DAGK181", "gene_reaction_rule": "ECS88_4515"}, {"subsystem": "Transport, Inner Membrane", "name": "D-alanine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DALAt2pp"]}, "metabolites": {"ala__D_c": 1.0, "h_c": 1.0, "h_p": -1.0, "ala__D_p": -1.0}, "id": "DALAt2pp", "gene_reaction_rule": "ECS88_4802"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-Alanine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DALAtex"]}, "metabolites": {"ala__D_e": -1.0, "ala__D_p": 1.0}, "id": "DALAtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "DAMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DAMPtex"]}, "metabolites": {"damp_p": 1.0, "damp_e": -1.0}, "id": "DAMPtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2,3-diaminopropionate amonnia lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAPAL"]}, "metabolites": {"pyr_c": 1.0, "h2o_c": -1.0, "23dappa_c": -1.0, "nh4_c": 2.0}, "id": "DAPAL", "gene_reaction_rule": "ECS88_3150"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Diaminopimelate decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAPDC"]}, "metabolites": {"co2_c": 1.0, "lys__L_c": 1.0, "h_c": -1.0, "26dap__M_c": -1.0}, "id": "DAPDC", "gene_reaction_rule": "ECS88_3135"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Diaminopimelate epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DAPE"]}, "metabolites": {"26dap_LL_c": -1.0, "26dap__M_c": 1.0}, "id": "DAPE", "gene_reaction_rule": "ECS88_4235"}, {"subsystem": "Transport, Inner Membrane", "name": "M-diaminopimelic acid ABC transport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAPabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "26dap__M_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "26dap__M_p": -1.0}, "id": "DAPabcpp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "1,5-Diaminopentane transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DAPtex"]}, "metabolites": {"15dap_p": 1.0, "15dap_e": -1.0}, "id": "DAPtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-diacylglycerol synthetase (n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DASYN120"]}, "metabolites": {"ctp_c": -1.0, "cdpdddecg_c": 1.0, "ppi_c": 1.0, "pa120_c": -1.0, "h_c": -1.0}, "id": "DASYN120", "gene_reaction_rule": "ECS88_0185"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-diacylglycerol synthetase (n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DASYN140"]}, "metabolites": {"ctp_c": -1.0, "cdpdtdecg_c": 1.0, "ppi_c": 1.0, "pa140_c": -1.0, "h_c": -1.0}, "id": "DASYN140", "gene_reaction_rule": "ECS88_0185"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-diacylglycerol synthetase (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DASYN141"]}, "metabolites": {"ctp_c": -1.0, "pa141_c": -1.0, "ppi_c": 1.0, "h_c": -1.0, "cdpdtdec7eg_c": 1.0}, "id": "DASYN141", "gene_reaction_rule": "ECS88_0185"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-diacylglycerol synthetase (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DASYN160"]}, "metabolites": {"ctp_c": -1.0, "pa160_c": -1.0, "ppi_c": 1.0, "h_c": -1.0, "cdpdhdecg_c": 1.0}, "id": "DASYN160", "gene_reaction_rule": "ECS88_0185"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-diacylglycerol synthetase (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DASYN161"]}, "metabolites": {"pa161_c": -1.0, "ctp_c": -1.0, "ppi_c": 1.0, "cdpdhdec9eg_c": 1.0, "h_c": -1.0}, "id": "DASYN161", "gene_reaction_rule": "ECS88_0185"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-diacylglycerol synthetase (n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DASYN180"]}, "metabolites": {"ctp_c": -1.0, "cdpdodecg_c": 1.0, "ppi_c": 1.0, "h_c": -1.0, "pa180_c": -1.0}, "id": "DASYN180", "gene_reaction_rule": "ECS88_0185"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-diacylglycerol synthetase (n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DASYN181"]}, "metabolites": {"ctp_c": -1.0, "pa181_c": -1.0, "ppi_c": 1.0, "h_c": -1.0, "cdpdodec11eg_c": 1.0}, "id": "DASYN181", "gene_reaction_rule": "ECS88_0185"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "DATP amine hydrolysis (spontaneous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DATPHs"]}, "metabolites": {"datp_c": -1.0, "h2o_c": -1.0, "ditp_c": 1.0, "h_c": -1.0, "nh4_c": 1.0}, "id": "DATPHs", "gene_reaction_rule": "s0001"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "3,4-Dihydroxy-2-butanone-4-phosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DB4PS"]}, "metabolites": {"h_c": 1.0, "db4p_c": 1.0, "for_c": 1.0, "ru5p__D_c": -1.0}, "id": "DB4PS", "gene_reaction_rule": "ECS88_3444"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dethiobiotin synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DBTS"]}, "metabolites": {"co2_c": -1.0, "dann_c": -1.0, "dtbt_c": 1.0, "h_c": 3.0, "adp_c": 1.0, "pi_c": 1.0, "atp_c": -1.0}, "id": "DBTS", "gene_reaction_rule": "ECS88_0795"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Diacetylchitobiose-6-phosphate hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DC6PH"]}, "metabolites": {"acgam_c": 1.0, "h2o_c": -1.0, "chtbs6p_c": -1.0, "acgam6p_c": 1.0}, "id": "DC6PH", "gene_reaction_rule": "ECS88_1786"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Decanoate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DCAtex"]}, "metabolites": {"dca_e": -1.0, "dca_p": 1.0}, "id": "DCAtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "DCMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DCMPtex"]}, "metabolites": {"dcmp_p": 1.0, "dcmp_e": -1.0}, "id": "DCMPtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "DCTP deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DCTPD"]}, "metabolites": {"dutp_c": 1.0, "nh4_c": 1.0, "h_c": -1.0, "h2o_c": -1.0, "dctp_c": -1.0}, "id": "DCTPD", "gene_reaction_rule": "ECS88_2164"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Deoxycytidine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DCYTD"]}, "metabolites": {"dcyt_c": -1.0, "h2o_c": -1.0, "h_c": -1.0, "duri_c": 1.0, "nh4_c": 1.0}, "id": "DCYTD", "gene_reaction_rule": "ECS88_2289"}, {"subsystem": "Transport, Inner Membrane", "name": "Deoxycytidine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DCYTt2pp"]}, "metabolites": {"dcyt_c": 1.0, "dcyt_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "DCYTt2pp", "gene_reaction_rule": "ECS88_2587 or ECS88_3247"}, {"subsystem": "Transport, Outer Membrane", "name": "Deoxycytidine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DCYTtex"]}, "metabolites": {"dcyt_p": 1.0, "dcyt_e": -1.0}, "id": "DCYTtex", "gene_reaction_rule": "ECS88_0406"}, {"subsystem": "Transport, Outer Membrane", "name": "Fatty acid (dodecanoate) transport via facilitated irreversible diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DDCAtexi"]}, "metabolites": {"ddca_p": 1.0, "ddca_e": -1.0}, "id": "DDCAtexi", "gene_reaction_rule": "ECS88_2491"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-dehydro-3-deoxygalactonokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DDGALK"]}, "metabolites": {"2dh3dgal6p_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "2dh3dgal_c": -1.0}, "id": "DDGALK", "gene_reaction_rule": "ECS88_4117"}, {"subsystem": "Transport, Inner Membrane", "name": "2-dehydro-3-deoxy-D-gluconate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DDGLCNt2rpp"]}, "metabolites": {"2ddglcn_p": -1.0, "2ddglcn_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "DDGLCNt2rpp", "gene_reaction_rule": "ECS88_4359"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "2-dehydro-3-deoxy-D-gluconate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DDGLCNtex"]}, "metabolites": {"2ddglcn_p": 1.0, "2ddglcn_e": -1.0}, "id": "DDGLCNtex", "gene_reaction_rule": "ECS88_0957 or ECS88_1492 or ECS88_2364 or ECS88_0276"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-dehydro-3-deoxygluconokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DDGLK"]}, "metabolites": {"h_c": 1.0, "2ddglcn_c": -1.0, "adp_c": 1.0, "atp_c": -1.0, "2ddg6p_c": 1.0}, "id": "DDGLK", "gene_reaction_rule": "ECS88_3940"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DDPA"]}, "metabolites": {"pep_c": -1.0, "e4p_c": -1.0, "pi_c": 1.0, "2dda7p_c": 1.0, "h2o_c": -1.0}, "id": "DDPA", "gene_reaction_rule": "ECS88_2787 or ECS88_0770 or ECS88_1755"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-dehydro-3-deoxy-6-phosphogalactonate aldolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DDPGALA"]}, "metabolites": {"2dh3dgal6p_c": -1.0, "pyr_c": 1.0, "g3p_c": 1.0}, "id": "DDPGALA", "gene_reaction_rule": "ECS88_4116"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Deoxyguanylate kinase (dGMP:ATP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DGK1"]}, "metabolites": {"dgdp_c": 1.0, "dgmp_c": -1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "DGK1", "gene_reaction_rule": "ECS88_4063"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "DGMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DGMPtex"]}, "metabolites": {"dgmp_e": -1.0, "dgmp_p": 1.0}, "id": "DGMPtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "Deoxyguanosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DGSNt2pp"]}, "metabolites": {"dgsn_c": 1.0, "dgsn_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "DGSNt2pp", "gene_reaction_rule": "ECS88_3247"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Deoxyguanosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DGSNtex"]}, "metabolites": {"dgsn_p": 1.0, "dgsn_e": -1.0}, "id": "DGSNtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHAD1"]}, "metabolites": {"h2o_c": 1.0, "23dhmb_c": -1.0, "3mob_c": 1.0}, "id": "DHAD1", "gene_reaction_rule": "ECS88_4194"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHAD2"]}, "metabolites": {"23dhmp_c": -1.0, "3mop_c": 1.0, "h2o_c": 1.0}, "id": "DHAD2", "gene_reaction_rule": "ECS88_4194"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Dihydroxyacetone phosphotransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHAPT"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "dhap_c": 1.0, "dha_c": -1.0}, "id": "DHAPT", "gene_reaction_rule": "ECS88_1268 and ECS88_1267 and ECS88_1266 and ECS88_2605 and ECS88_2606"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Dihydroxyacetone transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHAtex"]}, "metabolites": {"dha_e": -1.0, "dha_p": 1.0}, "id": "DHAtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "Dihydroxyacetone transport via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHAtpp"]}, "metabolites": {"dha_p": -1.0, "dha_c": 1.0}, "id": "DHAtpp", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHBD"]}, "metabolites": {"23dhb_c": 1.0, "nadh_c": 1.0, "23ddhb_c": -1.0, "nad_c": -1.0, "h_c": 1.0}, "id": "DHBD", "gene_reaction_rule": "ECS88_0635"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2,3-dihydroxybenzoate adenylate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHBS"]}, "metabolites": {"23dhba_c": 1.0, "23dhb_c": -1.0, "ppi_c": 1.0, "h_c": -1.0, "atp_c": -1.0}, "id": "DHBS", "gene_reaction_rule": "ECS88_0633"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2,3-dihydroxybenzoylserine hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHBSH"]}, "metabolites": {"23dhb_c": 1.0, "ser__L_c": 1.0, "h2o_c": -1.0, "23dhbzs_c": -1.0}, "id": "DHBSH", "gene_reaction_rule": ""}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Dihydrodipicolinate reductase (NADPH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHDPRy"]}, "metabolites": {"thdp_c": 1.0, "23dhdp_c": -1.0, "nadph_c": -1.0, "nadp_c": 1.0, "h_c": -1.0}, "id": "DHDPRy", "gene_reaction_rule": "ECS88_0031"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Dihydrodipicolinate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHDPS"]}, "metabolites": {"aspsa_c": -1.0, "pyr_c": -1.0, "23dhdp_c": 1.0, "h2o_c": 2.0, "h_c": 1.0}, "id": "DHDPS", "gene_reaction_rule": "ECS88_2660"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydrofolate reductase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHFR"]}, "metabolites": {"dhf_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "thf_c": 1.0, "h_c": -1.0}, "id": "DHFR", "gene_reaction_rule": "ECS88_1651 or ECS88_0051"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydrofolate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHFS"]}, "metabolites": {"dhf_c": 1.0, "atp_c": -1.0, "glu__L_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "dhpt_c": -1.0, "pi_c": 1.0}, "id": "DHFS", "gene_reaction_rule": "ECS88_2462"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydromonapterin reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHMPTR"]}, "metabolites": {"nadph_c": -1.0, "thmnp_c": 1.0, "nadp_c": 1.0, "dhmpt_c": -1.0, "h_c": -1.0}, "id": "DHMPTR", "gene_reaction_rule": "ECS88_1651"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "1,4-dihydroxy-2-naphthoate octaprenyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHNAOT4"]}, "metabolites": {"co2_c": 1.0, "octdp_c": -1.0, "ppi_c": 1.0, "2dmmql8_c": 1.0, "h_c": -1.0, "dhna_c": -1.0}, "id": "DHNAOT4", "gene_reaction_rule": "ECS88_4380"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "1,4-dihydroxy-2-napthoyl-CoA synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHNCOAS"]}, "metabolites": {"sbzcoa_c": -1.0, "h2o_c": 1.0, "h_c": -1.0, "14dhncoa_c": 1.0}, "id": "DHNCOAS", "gene_reaction_rule": "ECS88_2413"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "1,4-dihydroxy-2-napthoyl-CoA thioesterase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHNCOAT"]}, "metabolites": {"h2o_c": -1.0, "dhna_c": 1.0, "coa_c": 1.0, "h_c": 1.0, "14dhncoa_c": -1.0}, "id": "DHNCOAT", "gene_reaction_rule": "ECS88_0759"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydroneopterin aldolase reversible", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHNPA2r"]}, "metabolites": {"dhnpt_c": -1.0, "6hmhpt_c": 1.0, "gcald_c": 1.0}, "id": "DHNPA2r", "gene_reaction_rule": "ECS88_3456"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydroneopterin epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHNPTE"]}, "metabolites": {"dhnpt_c": -1.0, "dhmpt_c": 1.0}, "id": "DHNPTE", "gene_reaction_rule": "ECS88_3456"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Dihydoorotic acid dehydrogenase (quinone8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHORD2"]}, "metabolites": {"q8h2_c": 1.0, "dhor__S_c": -1.0, "q8_c": -1.0, "orot_c": 1.0}, "id": "DHORD2", "gene_reaction_rule": "ECS88_0966"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Dihydroorotic acid (menaquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHORD5"]}, "metabolites": {"dhor__S_c": -1.0, "mqn8_c": -1.0, "mql8_c": 1.0, "orot_c": 1.0}, "id": "DHORD5", "gene_reaction_rule": "ECS88_0966"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Fumarate dependent DHORD", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHORDfum"]}, "metabolites": {"fum_c": -1.0, "succ_c": 1.0, "dhor__S_c": -1.0, "orot_c": 1.0}, "id": "DHORDfum", "gene_reaction_rule": ""}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Dihydroorotase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHORTS"]}, "metabolites": {"cbasp_c": 1.0, "h2o_c": -1.0, "dhor__S_c": -1.0, "h_c": 1.0}, "id": "DHORTS", "gene_reaction_rule": "ECS88_1076"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Diaminohydroxyphosphoribosylaminopryrimidine deaminase (25drapp)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPPDA2"]}, "metabolites": {"5apru_c": 1.0, "h2o_c": -1.0, "nh4_c": 1.0, "25drapp_c": -1.0, "h_c": -1.0}, "id": "DHPPDA2", "gene_reaction_rule": "ECS88_0409"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydropteroate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPS2"]}, "metabolites": {"dhpt_c": 1.0, "6hmhptpp_c": -1.0, "ppi_c": 1.0, "4abz_c": -1.0}, "id": "DHPS2", "gene_reaction_rule": "ECS88_3559"}, {"subsystem": "Methionine Metabolism", "name": "4,5-dihydroxy-2,3-pentanedione cyclization (spontaneous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPTDCs2"]}, "metabolites": {"dhptd_c": -1.0, "mdhdhf_c": 1.0}, "id": "DHPTDCs2", "gene_reaction_rule": "s0001"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Dihydropteridine reductase", "upper_bound": 0.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPTDNR"]}, "metabolites": {"dhptdn_c": -1.0, "thptdn_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -3.0}, "id": "DHPTDNR", "gene_reaction_rule": "ECS88_0615"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Dihydropteridine reductase (NADH)", "upper_bound": 0.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPTDNRN"]}, "metabolites": {"dhptdn_c": -1.0, "thptdn_c": 1.0, "nadh_c": -1.0, "h_c": -3.0, "nad_c": 1.0}, "id": "DHPTDNRN", "gene_reaction_rule": "ECS88_0615"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydroneopterin triphosphate 2'-epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHPTPE"]}, "metabolites": {"dhmptp_c": 1.0, "ahdt_c": -1.0}, "id": "DHPTPE", "gene_reaction_rule": "ECS88_2450"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "3-dehydroquinate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHQS"]}, "metabolites": {"3dhq_c": 1.0, "pi_c": 1.0, "2dda7p_c": -1.0}, "id": "DHQS", "gene_reaction_rule": "ECS88_3774"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "3-dehydroquinate dehydratase, irreversible", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHQTi"]}, "metabolites": {"3dhsk_c": 1.0, "h2o_c": 1.0, "3dhq_c": -1.0}, "id": "DHQTi", "gene_reaction_rule": "ECS88_1743"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "DIMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DIMPtex"]}, "metabolites": {"dimp_p": 1.0, "dimp_e": -1.0}, "id": "DIMPtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "Deoxyinosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DINSt2pp"]}, "metabolites": {"din_p": -1.0, "din_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "DINSt2pp", "gene_reaction_rule": "ECS88_3247"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Deoxyinosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DINStex"]}, "metabolites": {"din_p": 1.0, "din_e": -1.0}, "id": "DINStex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2,5-diketo-D-gluconate reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DKGLCNR1"]}, "metabolites": {"25dkglcn_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "2dhguln_c": 1.0}, "id": "DKGLCNR1", "gene_reaction_rule": "ECS88_0222 or ECS88_3392"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2,5-diketo-D-gluconate reductase (NADH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DKGLCNR2x"]}, "metabolites": {"nad_c": 1.0, "25dkglcn_c": -1.0, "5dglcn_c": 1.0, "h_c": -1.0, "nadh_c": -1.0}, "id": "DKGLCNR2x", "gene_reaction_rule": "ECS88_3972"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2,5-diketo-D-gluconate reductase (NADPH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DKGLCNR2y"]}, "metabolites": {"nadph_c": -1.0, "25dkglcn_c": -1.0, "5dglcn_c": 1.0, "nadp_c": 1.0, "h_c": -1.0}, "id": "DKGLCNR2y", "gene_reaction_rule": "ECS88_3972"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dimethylallyltranstransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DMATT"]}, "metabolites": {"dmpp_c": -1.0, "ppi_c": 1.0, "ipdp_c": -1.0, "grdp_c": 1.0}, "id": "DMATT", "gene_reaction_rule": "ECS88_0416"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (dmpp)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DMPPS"]}, "metabolites": {"h2o_c": 1.0, "dmpp_c": 1.0, "h2mb4p_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "nadh_c": -1.0}, "id": "DMPPS", "gene_reaction_rule": "ECS88_0028"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "3-Dimethylubiquinonol 3-methyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DMQMT"]}, "metabolites": {"q8h2_c": 1.0, "2omhmbl_c": -1.0, "ahcys_c": 1.0, "h_c": 1.0, "amet_c": -1.0}, "id": "DMQMT", "gene_reaction_rule": "ECS88_2380"}, {"subsystem": "Oxidative Phosphorylation", "name": "Dimethyl sulfoxide reductase (Menaquinol 8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DMSOR1"]}, "metabolites": {"dms_c": 1.0, "h2o_c": 1.0, "dmso_c": -1.0, "mqn8_c": 1.0, "mql8_c": -1.0}, "id": "DMSOR1", "gene_reaction_rule": "ECS88_1632 and ECS88_1633 and ECS88_1634 and ECS88_1635"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Dimethyl sulfoxide transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DMSOtex"]}, "metabolites": {"dmso_p": 1.0, "dmso_e": -1.0}, "id": "DMSOtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "Dimethyl sulfoxide transport via diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DMSOtpp"]}, "metabolites": {"dmso_p": -1.0, "dmso_c": 1.0}, "id": "DMSOtpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Dimethyl sulfide transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DMStex"]}, "metabolites": {"dms_p": 1.0, "dms_e": -1.0}, "id": "DMStex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydroneopterin monophosphate dephosphorylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DNMPPA"]}, "metabolites": {"dhnpt_c": 1.0, "pi_c": 1.0, "h2o_c": -1.0, "dhpmp_c": -1.0}, "id": "DNMPPA", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydroneopterin triphosphate pyrophosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DNTPPA"]}, "metabolites": {"dhpmp_c": 1.0, "ppi_c": 1.0, "h_c": 1.0, "h2o_c": -1.0, "ahdt_c": -1.0}, "id": "DNTPPA", "gene_reaction_rule": "ECS88_0103 or ECS88_1923"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2,3 dioxo-L-gulonate reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DOGULNR"]}, "metabolites": {"nad_c": 1.0, "nadh_c": -1.0, "23doguln_c": -1.0, "h_c": -1.0, "3dhguln_c": 1.0}, "id": "DOGULNR", "gene_reaction_rule": "ECS88_3994"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Dopamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DOPAtex"]}, "metabolites": {"dopa_e": -1.0, "dopa_p": 1.0}, "id": "DOPAtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Doxorubicin transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DOXRBCNtex"]}, "metabolites": {"doxrbcn_e": -1.0, "doxrbcn_p": 1.0}, "id": "DOXRBCNtex", "gene_reaction_rule": "ECS88_1492 or ECS88_2364 or ECS88_0957 or ECS88_0276"}, {"subsystem": "Transport, Outer Membrane", "name": "Doxorubicin transport via TolC system", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DOXRBCNtpp"]}, "metabolites": {"doxrbcn_p": -1.0, "doxrbcn_e": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "DOXRBCNtpp", "gene_reaction_rule": "ECS88_0460 and ECS88_2649 and ECS88_3429"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dephospho-CoA kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DPCOAK"]}, "metabolites": {"dpcoa_c": -1.0, "coa_c": 1.0, "adp_c": 1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "DPCOAK", "gene_reaction_rule": "ECS88_0106"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2-dehydropantoate 2-reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DPR"]}, "metabolites": {"pant__R_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "2dhp_c": -1.0}, "id": "DPR", "gene_reaction_rule": "ECS88_0421 or ECS88_4197"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Deoxyribose-phosphate aldolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DRPA"]}, "metabolites": {"acald_c": 1.0, "g3p_c": 1.0, "2dr5p_c": -1.0}, "id": "DRPA", "gene_reaction_rule": "ECS88_5062"}, {"subsystem": "Unassigned", "name": "DsbA protein reoxidation reaction (aerobic)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DSBAO1"]}, "metabolites": {"q8h2_c": 1.0, "dsbaox_p": 1.0, "q8_c": -1.0, "dsbard_p": -1.0}, "id": "DSBAO1", "gene_reaction_rule": "ECS88_4310 and ECS88_1248"}, {"subsystem": "Unassigned", "name": "DsbA protein reoxidation reaction (anaerobic)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DSBAO2"]}, "metabolites": {"dsbaox_p": 1.0, "mqn8_c": -1.0, 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(3-hydroxyoctanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH3"]}, "metabolites": {"oc2coa_c": 1.0, "h2o_c": 1.0, "3hocoa_c": -1.0}, "id": "ECOAH3", "gene_reaction_rule": "ECS88_4294 or ECS88_2488"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxydecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH4"]}, "metabolites": {"3hdcoa_c": -1.0, "h2o_c": 1.0, "dc2coa_c": 1.0}, "id": "ECOAH4", "gene_reaction_rule": "ECS88_4294 or ECS88_2488"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxydodecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH5"]}, "metabolites": {"h2o_c": 1.0, "3hddcoa_c": -1.0, "dd2coa_c": 1.0}, "id": "ECOAH5", "gene_reaction_rule": "ECS88_4294 or ECS88_2488"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxytetradecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH6"]}, "metabolites": {"h2o_c": 1.0, "3htdcoa_c": -1.0, "td2coa_c": 1.0}, "id": "ECOAH6", "gene_reaction_rule": "ECS88_4294 or ECS88_2488"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxyhexadecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH7"]}, "metabolites": {"h2o_c": 1.0, "hdd2coa_c": 1.0, "3hhdcoa_c": -1.0}, "id": "ECOAH7", "gene_reaction_rule": "ECS88_4294 or ECS88_2488"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxyoctadecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH8"]}, "metabolites": {"3hodcoa_c": -1.0, "h2o_c": 1.0, "od2coa_c": 1.0}, "id": "ECOAH8", "gene_reaction_rule": "ECS88_4294 or ECS88_2488"}, {"subsystem": "Pentose Phosphate Pathway", "name": "2-dehydro-3-deoxy-phosphogluconate aldolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EDA"]}, "metabolites": {"pyr_c": 1.0, "g3p_c": 1.0, "2ddg6p_c": -1.0}, "id": "EDA", "gene_reaction_rule": "ECS88_1906"}, {"subsystem": "Pentose Phosphate Pathway", "name": "6-phosphogluconate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EDD"]}, "metabolites": {"6pgc_c": -1.0, "h2o_c": 1.0, "2ddg6p_c": 1.0}, "id": "EDD", "gene_reaction_rule": "ECS88_1907"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Endotoxin Synthesis (lauroyl transferase)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EDTXS1"]}, "metabolites": {"kdo2lipid4_c": -1.0, "kdo2lipid4L_c": 1.0, "ACP_c": 1.0, "ddcaACP_c": -1.0}, "id": "EDTXS1", "gene_reaction_rule": "ECS88_1068"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Endotoxin Synthesis (myristoyl transferase)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EDTXS2"]}, "metabolites": {"kdo2lipid4L_c": -1.0, "ACP_c": 1.0, "lipa_c": 1.0, "myrsACP_c": -1.0}, "id": "EDTXS2", "gene_reaction_rule": "ECS88_1912"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Endotoxin Synthesis (palmitoleoyl ACP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EDTXS3"]}, "metabolites": {"kdo2lipid4_c": -1.0, "ACP_c": 1.0, "hdeACP_c": -1.0, "kdo2lipid4p_c": 1.0}, "id": "EDTXS3", "gene_reaction_rule": "ECS88_2573"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Endotoxin Synthesis (myristoyl transferase)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EDTXS4"]}, "metabolites": {"ACP_c": 1.0, "lipa_cold_c": 1.0, "kdo2lipid4p_c": -1.0, "myrsACP_c": -1.0}, "id": "EDTXS4", "gene_reaction_rule": "ECS88_1912"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Enoylglutaryl-[ACP] methyl ester reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EGMEACPR"]}, "metabolites": {"egmeACP_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "gmeACP_c": 1.0}, "id": "EGMEACPR", "gene_reaction_rule": "ECS88_1430"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Phosphoethanolamine lipid A transport via ABC system (periplasm to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ENLIPAabctex"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "enlipa_e": 1.0, "h_c": 1.0, "adp_c": 1.0, "enlipa_p": -1.0, "pi_c": 1.0}, "id": "ENLIPAabctex", "gene_reaction_rule": "ECS88_3583 and ECS88_3584 and ECS88_3582 and ECS88_4848 and ECS88_4849"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Enolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ENO"]}, "metabolites": {"pep_c": 1.0, "h2o_c": 1.0, "2pg_c": -1.0}, "id": "ENO", "gene_reaction_rule": "ECS88_3047"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Enterochelin synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ENTCS"]}, "metabolites": {"23dhba_c": -3.0, "seramp_c": -3.0, "amp_c": 6.0, "h_c": 9.0, "enter_c": 1.0}, "id": "ENTCS", "gene_reaction_rule": "ECS88_0621"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Enterochelin Esterase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ENTERES"]}, "metabolites": {"h2o_c": -3.0, "enter_c": -1.0, "h_c": 3.0, "23dhbzs_c": 3.0}, "id": "ENTERES", "gene_reaction_rule": "ECS88_0623"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Enterochelin Esterase (Fe containing)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ENTERES2"]}, "metabolites": {"fe3_c": 1.0, "h2o_c": -3.0, "feenter_c": -1.0, "h_c": 3.0, "23dhbzs_c": 3.0}, "id": "ENTERES2", "gene_reaction_rule": "ECS88_0623"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Enoylpimeloyl-[ACP] methyl ester reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EPMEACPR"]}, "metabolites": {"pmeACP_c": 1.0, "epmeACP_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0}, "id": "EPMEACPR", "gene_reaction_rule": "ECS88_1430"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Ethanolamine ammonia-lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ETHAAL"]}, "metabolites": {"acald_c": 1.0, "nh4_c": 1.0, "etha_c": -1.0}, "id": "ETHAAL", "gene_reaction_rule": "ECS88_2628 and ECS88_2629"}, {"subsystem": "Transport, Inner Membrane", "name": "Ethanolamine transport in via proton symport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ETHAt2pp"]}, "metabolites": {"h_c": 1.0, "etha_c": 1.0, "h_p": -1.0, "etha_p": -1.0}, "id": "ETHAt2pp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Ethanolamine transport via diffusion (extracellular)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ETHAtex"]}, "metabolites": {"etha_e": -1.0, "etha_p": 1.0}, "id": "ETHAtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "Ethanesulfonate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ETHSO3abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "ethso3_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "ethso3_p": -1.0}, "id": "ETHSO3abcpp", "gene_reaction_rule": "ECS88_0964 and ECS88_0961 and ECS88_0962"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Ethanesulfonate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ETHSO3tex"]}, "metabolites": {"ethso3_e": -1.0, "ethso3_p": 1.0}, "id": "ETHSO3tex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Ethanol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ETOHtex"]}, "metabolites": {"etoh_e": -1.0, "etoh_p": 1.0}, "id": "ETOHtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "Ethanol reversible transport via diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ETOHtrpp"]}, "metabolites": {"etoh_p": -1.0, "etoh_c": 1.0}, "id": "ETOHtrpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Fructose 6-phosphate aldolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["F6PA"]}, "metabolites": {"g3p_c": 1.0, "dha_c": 1.0, "f6p_c": -1.0}, "id": "F6PA", "gene_reaction_rule": "ECS88_0842 or ECS88_4402"}, {"subsystem": "Alternate Carbon Metabolism", "name": "D-fructose 6-phosphate phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["F6PP"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "fru_c": 1.0, "f6p_c": -1.0}, "id": "F6PP", "gene_reaction_rule": "ECS88_0839"}, {"subsystem": "Transport, Inner Membrane", "name": "Fructose-6-phosphate transport via phosphate antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["F6Pt6_2pp"]}, "metabolites": {"pi_p": 2.0, "pi_c": -2.0, "f6p_p": -1.0, "f6p_c": 1.0}, "id": "F6Pt6_2pp", "gene_reaction_rule": "ECS88_4091"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Fructose 6-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["F6Ptex"]}, "metabolites": {"f6p_e": -1.0, "f6p_p": 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{"subsystem": "Glycolysis/Gluconeogenesis", "name": "Fructose-bisphosphate aldolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FBA"]}, "metabolites": {"dhap_c": 1.0, "g3p_c": 1.0, "fdp_c": -1.0}, "id": "FBA", "gene_reaction_rule": "ECS88_2239 or ECS88_1825 or ECS88_3201"}, {"subsystem": "Pentose Phosphate Pathway", "name": "Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FBA3"]}, "metabolites": {"e4p_c": 1.0, "dhap_c": 1.0, "s17bp_c": -1.0}, "id": "FBA3", "gene_reaction_rule": "ECS88_3201"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Fructose-bisphosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FBP"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "fdp_c": -1.0, "f6p_c": 1.0}, "id": "FBP", "gene_reaction_rule": "ECS88_4375 or ECS88_4822"}, {"subsystem": "Alternate Carbon Metabolism", "name": "L-fucose 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"Ferrichrome reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FECRMR2"]}, "metabolites": {"fe2_c": 2.0, "fecrm_c": -2.0, "fmnh2_c": -1.0, "fmn_c": 1.0, "fecrm_un_c": 2.0, "h_c": 2.0}, "id": "FECRMR2", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Ferrichrome reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FECRMR3"]}, "metabolites": {"rbflvrd_c": -1.0, "fe2_c": 2.0, "fecrm_c": -2.0, "fecrm_un_c": 2.0, "h_c": 2.0, "ribflv_c": 1.0}, "id": "FECRMR3", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Ferrichrome (minus Fe) secretion (to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FECRMUtex"]}, "metabolites": {"fecrm_un_e": 1.0, "fecrm_un_p": -1.0, "h_p": -1.0, "h_c": 1.0}, "id": "FECRMUtex", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", 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1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FORt2pp"]}, "metabolites": {"h_p": -1.0, "h_c": 1.0, "for_c": 1.0, "for_p": -1.0}, "id": "FORt2pp", "gene_reaction_rule": "ECS88_0932"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Formate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FORtex"]}, "metabolites": {"for_e": -1.0, "for_p": 1.0}, "id": "FORtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "Formate transport via diffusion (cytoplasm to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FORtppi"]}, "metabolites": {"for_p": 1.0, "for_c": -1.0}, "id": "FORtppi", "gene_reaction_rule": "ECS88_0932"}, {"subsystem": "Citric Acid Cycle", "name": "Fumarate reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FRD2"]}, "metabolites": {"succ_c": 1.0, "fum_c": -1.0, "mqn8_c": 1.0, "mql8_c": -1.0}, "id": "FRD2", "gene_reaction_rule": "ECS88_4739 and ECS88_4740 and ECS88_4741 and ECS88_4742"}, {"subsystem": "Citric Acid Cycle", "name": "Fumarate reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FRD3"]}, "metabolites": {"succ_c": 1.0, "fum_c": -1.0, "2dmmq8_c": 1.0, "2dmmql8_c": -1.0}, "id": "FRD3", "gene_reaction_rule": "ECS88_4739 and ECS88_4740 and ECS88_4741 and ECS88_4742"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Fructose-1-phosphate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FRUK"]}, "metabolites": {"h_c": 1.0, "f1p_c": -1.0, "adp_c": 1.0, "atp_c": -1.0, "fdp_c": 1.0}, "id": "FRUK", "gene_reaction_rule": "ECS88_2316"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Fructoselysine transporter via diffusion (extracellular)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FRULYStex"]}, "metabolites": {"frulys_p": 1.0, "frulys_e": -1.0}, "id": "FRULYStex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "D-fructuronate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FRUURt2rpp"]}, "metabolites": {"h_c": 1.0, "fruur_p": -1.0, "h_p": -1.0, "fruur_c": 1.0}, "id": "FRUURt2rpp", "gene_reaction_rule": "ECS88_4939"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-fructuronate transport via diffusion (extracellular)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FRUURtex"]}, "metabolites": {"fruur_e": -1.0, "fruur_p": 1.0}, "id": "FRUURtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "Fructose transport via PEP:Pyr PTS (f6p generating) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FRUpts2pp"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "fru_p": -1.0, "f6p_c": 1.0}, "id": "FRUpts2pp", "gene_reaction_rule": "ECS88_1869 and ECS88_1870 and ECS88_1871 and ECS88_2605 and ECS88_2606"}, {"subsystem": "Transport, Inner Membrane", "name": "D-fructose transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FRUptspp"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "f1p_c": 1.0, "fru_p": -1.0}, "id": "FRUptspp", "gene_reaction_rule": "ECS88_2315 and ECS88_2317 and ECS88_2605 and ECS88_2606"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-fructose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FRUtex"]}, "metabolites": {"fru_e": -1.0, "fru_p": 1.0}, "id": "FRUtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Folate Metabolism", "name": "Formyltetrahydrofolate deformylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FTHFD"]}, "metabolites": {"h2o_c": -1.0, "10fthf_c": -1.0, "h_c": 1.0, "for_c": 1.0, "thf_c": 1.0}, "id": "FTHFD", "gene_reaction_rule": "ECS88_1300"}, {"subsystem": "Folate Metabolism", "name": "Formate-tetrahydrofolate ligase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FTHFLi"]}, "metabolites": {"adp_c": 1.0, "atp_c": -1.0, "thf_c": -1.0, "for_c": -1.0, "pi_c": 1.0, "10fthf_c": 1.0}, "id": "FTHFLi", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-fucose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FUCtex"]}, "metabolites": {"fuc__L_p": 1.0, "fuc__L_e": -1.0}, "id": "FUCtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "L-fucose transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FUCtpp"]}, "metabolites": {"fuc__L_p": -1.0, "fuc__L_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "FUCtpp", "gene_reaction_rule": "ECS88_3070"}, {"subsystem": "Citric Acid Cycle", "name": "Fumarase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FUM"]}, "metabolites": {"h2o_c": -1.0, "fum_c": -1.0, "mal__L_c": 1.0}, "id": "FUM", "gene_reaction_rule": "ECS88_1658 or ECS88_1657"}, {"subsystem": "Transport, Inner Membrane", "name": "Fumarate transport via proton symport (2 H) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FUMt2_2pp"]}, "metabolites": {"fum_p": -1.0, "fum_c": 1.0, "h_c": 2.0, "h_p": -2.0}, "id": "FUMt2_2pp", "gene_reaction_rule": "ECS88_3942"}, {"subsystem": "Transport, Inner Membrane", "name": "Fumarate transport via proton symport (3 H) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FUMt2_3pp"]}, "metabolites": {"fum_p": -1.0, "fum_c": 1.0, "h_c": 3.0, "h_p": -3.0}, "id": "FUMt2_3pp", "gene_reaction_rule": "ECS88_4724 or ECS88_4624 or ECS88_0662"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Fumarate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FUMtex"]}, "metabolites": {"fum_p": 1.0, "fum_e": -1.0}, "id": "FUMtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Fusidic acid transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FUSAtex"]}, "metabolites": {"fusa_e": -1.0, "fusa_p": 1.0}, "id": "FUSAtex", "gene_reaction_rule": "ECS88_1492 or ECS88_2364 or ECS88_0957 or ECS88_0276"}, {"subsystem": "Transport, Outer Membrane", "name": "Fusidic acid transport via TolC system", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FUSAtpp"]}, "metabolites": {"fusa_e": 1.0, "fusa_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "FUSAtpp", "gene_reaction_rule": "ECS88_0460 and ECS88_2649 and ECS88_3429"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Glucosamine-1-phosphate N-acetyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G1PACT"]}, "metabolites": {"gam1p_c": -1.0, "coa_c": 1.0, "h_c": 1.0, "accoa_c": -1.0, "acgam1p_c": 1.0}, "id": "G1PACT", "gene_reaction_rule": "ECS88_4152"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Glucose-1-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G1PPpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "glc__D_p": 1.0, "g1p_p": -1.0}, "id": "G1PPpp", "gene_reaction_rule": "ECS88_1016"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Glucose-1-phosphate thymidylyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G1PTT"]}, "metabolites": {"dtdpglu_c": 1.0, "ppi_c": 1.0, "dttp_c": -1.0, "h_c": -1.0, "g1p_c": -1.0}, "id": "G1PTT", "gene_reaction_rule": "ECS88_4211"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-glucose 1-phosphate transport via diffusion", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G1Ptex"]}, "metabolites": {"g1p_e": -1.0, "g1p_p": 1.0}, "id": "G1Ptex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Glutamate-1-semialdehyde aminotransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G1SAT"]}, "metabolites": {"5aop_c": 1.0, "glu1sa_c": -1.0}, "id": "G1SAT", "gene_reaction_rule": "ECS88_0165"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glycerol-2-phosphate phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G2PP"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "glyc_c": 1.0, "glyc2p_c": -1.0}, "id": "G2PP", "gene_reaction_rule": "ECS88_2709"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glycerol 2-phosphate phosphatase (periplasmic)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G2PPpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "glyc2p_p": -1.0, "glyc_p": 1.0}, "id": "G2PPpp", "gene_reaction_rule": "ECS88_4544"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerol-3-phosphate acyltransferase (C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PAT120"]}, "metabolites": {"1ddecg3p_c": 1.0, "glyc3p_c": -1.0, "ACP_c": 1.0, "ddcaACP_c": -1.0}, "id": "G3PAT120", "gene_reaction_rule": "ECS88_1108 and ECS88_4514"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerol-3-phosphate acyltransferase (C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PAT140"]}, "metabolites": {"1tdecg3p_c": 1.0, "glyc3p_c": -1.0, "ACP_c": 1.0, "myrsACP_c": -1.0}, "id": "G3PAT140", "gene_reaction_rule": "ECS88_1108 and ECS88_4514"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerol-3-phosphate acyltransferase (C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PAT141"]}, "metabolites": {"tdeACP_c": -1.0, "glyc3p_c": -1.0, "ACP_c": 1.0, "1tdec7eg3p_c": 1.0}, "id": "G3PAT141", "gene_reaction_rule": "ECS88_1108 and ECS88_4514"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerol-3-phosphate acyltransferase (C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PAT160"]}, "metabolites": {"glyc3p_c": -1.0, "ACP_c": 1.0, "1hdecg3p_c": 1.0, "palmACP_c": -1.0}, "id": "G3PAT160", "gene_reaction_rule": "ECS88_1108 and ECS88_4514"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerol-3-phosphate acyltransferase (C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PAT161"]}, "metabolites": {"1hdec9eg3p_c": 1.0, "glyc3p_c": -1.0, "ACP_c": 1.0, "hdeACP_c": -1.0}, "id": "G3PAT161", "gene_reaction_rule": "ECS88_1108 and ECS88_4514"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerol-3-phosphate acyltransferase (C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PAT180"]}, "metabolites": {"glyc3p_c": -1.0, "ACP_c": 1.0, "ocdcaACP_c": -1.0, "1odecg3p_c": 1.0}, "id": "G3PAT180", "gene_reaction_rule": "ECS88_1108 and ECS88_4514"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerol-3-phosphate acyltransferase (C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PAT181"]}, "metabolites": {"1odec11eg3p_c": 1.0, "octeACP_c": -1.0, "ACP_c": 1.0, "glyc3p_c": -1.0}, "id": "G3PAT181", "gene_reaction_rule": "ECS88_1108 and ECS88_4514"}, {"subsystem": "Transport, Inner Membrane", "name": "Sn-glycerol-3-phosphocholine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PCabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "g3pc_p": -1.0, "g3pc_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "h_c": 1.0}, "id": "G3PCabcpp", "gene_reaction_rule": "ECS88_3849 and ECS88_3850 and ECS88_3847 and ECS88_3848"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glycero-3-phosphocholine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G3PCtex"]}, "metabolites": {"g3pc_e": -1.0, "g3pc_p": 1.0}, "id": "G3PCtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glycerol-3-phosphate dehydrogenase (NADP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G3PD2"]}, "metabolites": {"glyc3p_c": -1.0, "dhap_c": 1.0, "nadph_c": 1.0, "h_c": 1.0, "nadp_c": -1.0}, "id": "G3PD2", "gene_reaction_rule": "ECS88_4025"}, {"subsystem": "Oxidative Phosphorylation", "name": "Glycerol-3-phosphate dehydrogenase (ubiquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PD5"]}, "metabolites": {"q8h2_c": 1.0, "glyc3p_c": -1.0, "dhap_c": 1.0, "q8_c": -1.0}, "id": "G3PD5", "gene_reaction_rule": "(ECS88_2388 and ECS88_2389 and ECS88_2390) or ECS88_3815"}, {"subsystem": "Oxidative Phosphorylation", "name": "Glycerol-3-phosphate dehydrogenase (menaquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PD6"]}, "metabolites": {"glyc3p_c": -1.0, "dhap_c": 1.0, "mqn8_c": -1.0, "mql8_c": 1.0}, "id": "G3PD6", "gene_reaction_rule": "ECS88_2388 and ECS88_2389 and ECS88_2390"}, {"subsystem": "Oxidative Phosphorylation", "name": "Glycerol-3-phosphate dehydrogenase (demethylmenaquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PD7"]}, "metabolites": {"glyc3p_c": -1.0, "dhap_c": 1.0, "2dmmq8_c": -1.0, "2dmmql8_c": 1.0}, "id": "G3PD7", "gene_reaction_rule": "ECS88_2388 and ECS88_2389 and ECS88_2390"}, {"subsystem": "Transport, Inner Membrane", "name": "Sn-glycerol-3-phosphoethanolamine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PEabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "g3pe_c": 1.0, "g3pe_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "G3PEabcpp", "gene_reaction_rule": "ECS88_3849 and ECS88_3850 and ECS88_3847 and ECS88_3848"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glycero-3-phosphoethanolamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G3PEtex"]}, "metabolites": {"g3pe_e": -1.0, "g3pe_p": 1.0}, "id": "G3PEtex", "gene_reaction_rule": "ECS88_0957 or ECS88_1492 or ECS88_2364 or ECS88_0276"}, {"subsystem": "Transport, Inner Membrane", "name": "Sn-glycerol-3-phosphoglycerol transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PGabcpp"]}, "metabolites": {"g3pg_p": -1.0, "atp_c": -1.0, "h2o_c": -1.0, "g3pg_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "G3PGabcpp", "gene_reaction_rule": "ECS88_3849 and ECS88_3850 and ECS88_3847 and ECS88_3848"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glycerophoglycerol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G3PGtex"]}, "metabolites": {"g3pg_p": 1.0, "g3pg_e": -1.0}, "id": "G3PGtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "Sn-glycerol-3-phosphoethanolamine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PIabcpp"]}, "metabolites": {"g3pi_p": -1.0, "h2o_c": -1.0, "atp_c": -1.0, "g3pi_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "G3PIabcpp", "gene_reaction_rule": "ECS88_3849 and ECS88_3850 and ECS88_3847 and ECS88_3848"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glycero-3-phospho-1-inositol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G3PItex"]}, "metabolites": {"g3pi_p": 1.0, "g3pi_e": -1.0}, "id": "G3PItex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "Sn-glycerol-3-phosphoserine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PSabcpp"]}, "metabolites": {"h2o_c": -1.0, "g3ps_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "g3ps_p": -1.0, "pi_c": 1.0}, "id": "G3PSabcpp", "gene_reaction_rule": "ECS88_3849 and ECS88_3850 and ECS88_3847 and ECS88_3848"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glycerophosphserine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G3PStex"]}, "metabolites": {"g3ps_e": -1.0, "g3ps_p": 1.0}, "id": "G3PStex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glycerol-3-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PT"]}, "metabolites": {"glyc3p_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0, "glyc_c": 1.0}, "id": "G3PT", "gene_reaction_rule": "ECS88_0839"}, {"subsystem": "Arginine and Proline Metabolism", "name": "L-glutamate 5-semialdehyde dehydratase (spontaneous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G5SADs"]}, "metabolites": {"1pyr5c_c": 1.0, "glu5sa_c": -1.0, "h2o_c": 1.0, "h_c": 1.0}, "id": "G5SADs", "gene_reaction_rule": "s0001"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Glutamate-5-semialdehyde dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G5SD"]}, "metabolites": {"glu5sa_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "pi_c": 1.0, "glu5p_c": -1.0}, "id": "G5SD", "gene_reaction_rule": "ECS88_0278"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glucosamine-6-phosphate deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G6PDA"]}, "metabolites": {"gam6p_c": -1.0, "nh4_c": 1.0, "h2o_c": -1.0, "f6p_c": 1.0}, "id": "G6PDA", "gene_reaction_rule": "ECS88_0703"}, {"subsystem": "Pentose Phosphate Pathway", "name": "Glucose 6-phosphate dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G6PDH2r"]}, "metabolites": {"g6p_c": -1.0, "6pgl_c": 1.0, "nadph_c": 1.0, "h_c": 1.0, "nadp_c": -1.0}, "id": "G6PDH2r", "gene_reaction_rule": "ECS88_1909"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Glucose-6-phosphate phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G6PP"]}, "metabolites": {"glc__D_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0, "g6p_c": -1.0}, "id": "G6PP", "gene_reaction_rule": "ECS88_0839"}, {"subsystem": "Transport, Inner Membrane", "name": "Glucose-6-phosphate transport via phosphate antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G6Pt6_2pp"]}, "metabolites": {"pi_p": 2.0, "g6p_p": -1.0, "g6p_c": 1.0, "pi_c": -2.0}, "id": "G6Pt6_2pp", "gene_reaction_rule": "ECS88_4091"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glucose 6-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G6Ptex"]}, "metabolites": {"g6p_p": 1.0, "g6p_e": -1.0}, "id": "G6Ptex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Alternate Carbon Metabolism", "name": "D-galactose 1-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GAL1PPpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "gal_p": 1.0, "gal1p_p": -1.0}, "id": "GAL1PPpp", "gene_reaction_rule": "ECS88_1016"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-galactose 1-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GAL1Ptex"]}, "metabolites": {"gal1p_e": -1.0, "gal1p_p": 1.0}, "id": "GAL1Ptex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Beta D-galactose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALBDtex"]}, "metabolites": {"gal_bD_e": -1.0, "gal_bD_p": 1.0}, "id": "GALBDtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Galactarate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALCTD"]}, "metabolites": {"h2o_c": 1.0, "5dh4dglc_c": 1.0, "galct__D_c": -1.0}, "id": "GALCTD", "gene_reaction_rule": "ECS88_3516"}, {"subsystem": "Alternate Carbon Metabolism", "name": "L-galactonate oxidoreductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALCTLO"]}, "metabolites": {"galctn__L_c": -1.0, "nadh_c": 1.0, "tagur_c": 1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "GALCTLO", "gene_reaction_rule": "ECS88_4979"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Galactonate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALCTND"]}, "metabolites": {"galctn__D_c": -1.0, "h2o_c": 1.0, "2dh3dgal_c": 1.0}, "id": "GALCTND", "gene_reaction_rule": "ECS88_4115"}, {"subsystem": "Transport, Inner Membrane", "name": "L-galactonate transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALCTNLt2pp"]}, "metabolites": {"galctn__L_c": 1.0, "galctn__L_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GALCTNLt2pp", "gene_reaction_rule": "ECS88_4977"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-galactonate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALCTNLtex"]}, "metabolites": {"galctn__L_p": 1.0, "galctn__L_e": -1.0}, "id": "GALCTNLtex", "gene_reaction_rule": "ECS88_2364 or ECS88_1492 or ECS88_0957 or ECS88_0276"}, {"subsystem": "Transport, Inner Membrane", "name": "D-galactonate transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALCTNt2pp"]}, "metabolites": {"galctn__D_c": 1.0, "galctn__D_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GALCTNt2pp", "gene_reaction_rule": "ECS88_4114"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-galactonate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALCTNtex"]}, "metabolites": {"galctn__D_p": 1.0, "galctn__D_e": -1.0}, "id": "GALCTNtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "D-galactarte transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALCTt2rpp"]}, "metabolites": {"galct__D_p": -1.0, "galct__D_c": 1.0, "h_p": -1.0, "h_c": 1.0}, "id": "GALCTt2rpp", "gene_reaction_rule": "ECS88_3057 or ECS88_3515"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-galactarte transport via diffusion (extracellular to 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["GALS3"]}, "metabolites": {"glc__D_c": 1.0, "melib_c": -1.0, "gal_c": 1.0, "h2o_c": -1.0}, "id": "GALS3", "gene_reaction_rule": "ECS88_4621"}, {"subsystem": "Transport, Inner Membrane", "name": "Galactitol transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALTptspp"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "galt1p_c": 1.0, "galt_p": -1.0}, "id": "GALTptspp", "gene_reaction_rule": "ECS88_2236 and ECS88_2235 and ECS88_2234 and ECS88_2605 and ECS88_2606"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Galactitol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALTtex"]}, "metabolites": {"galt_e": -1.0, "galt_p": 1.0}, "id": "GALTtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "D-galacturonate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALURt2rpp"]}, "metabolites": {"galur_c": 1.0, "h_c": 1.0, "h_p": -1.0, "galur_p": -1.0}, "id": "GALURt2rpp", "gene_reaction_rule": "ECS88_3489"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-galacturonate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALURtex"]}, "metabolites": {"galur_e": -1.0, "galur_p": 1.0}, "id": "GALURtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UTP-glucose-1-phosphate uridylyltransferase (irreversible)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALUi"]}, "metabolites": {"utp_c": -1.0, "ppi_c": 1.0, "udpg_c": 1.0, "h_c": -1.0, "g1p_c": -1.0}, "id": "GALUi", "gene_reaction_rule": "ECS88_1304"}, {"subsystem": "Transport, Inner Membrane", "name": "D-galactose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "gal_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "gal_p": -1.0, "pi_c": 1.0}, "id": "GALabcpp", "gene_reaction_rule": "(ECS88_2295 and ECS88_2296 and ECS88_2294) or (ECS88_4821 and ECS88_4818 and ECS88_4819 and ECS88_4820)"}, {"subsystem": "Transport, Inner Membrane", "name": "D-galactose transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALt2pp"]}, "metabolites": {"gal_p": -1.0, "gal_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GALt2pp", "gene_reaction_rule": "ECS88_3225"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-galactose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALtex"]}, "metabolites": {"gal_p": 1.0, "gal_e": -1.0}, "id": "GALtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "D-Glucosamine 6-phosphate transport via phosphate antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GAM6Pt6_2pp"]}, "metabolites": {"pi_p": 2.0, "gam6p_p": -1.0, "gam6p_c": 1.0, "pi_c": -2.0}, "id": "GAM6Pt6_2pp", "gene_reaction_rule": "ECS88_4091"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-glucosamine 6-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GAMAN6Ptex"]}, "metabolites": {"gam6p_p": 1.0, "gam6p_e": -1.0}, "id": "GAMAN6Ptex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "D-glucosamine transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GAMptspp"]}, "metabolites": {"pep_c": -1.0, "gam_p": -1.0, "gam6p_c": 1.0, "pyr_c": 1.0}, "id": "GAMptspp", "gene_reaction_rule": "ECS88_1869 and ECS88_1870 and ECS88_1871 and ECS88_2605 and ECS88_2606"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-glucosamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GAMtex"]}, "metabolites": {"gam_p": 1.0, "gam_e": -1.0}, "id": "GAMtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Glyceraldehyde-3-phosphate dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GAPD"]}, "metabolites": {"nadh_c": 1.0, "nad_c": -1.0, "g3p_c": -1.0, "h_c": 1.0, "13dpg_c": 1.0, "pi_c": -1.0}, "id": "GAPD", "gene_reaction_rule": "ECS88_1832"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylglycinamide formyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GARFT"]}, "metabolites": {"thf_c": 1.0, "fgam_c": 1.0, "h_c": 1.0, "gar_c": -1.0, "10fthf_c": -1.0}, "id": "GARFT", "gene_reaction_rule": "ECS88_2672"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "GAR transformylase-T", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GART"]}, "metabolites": {"adp_c": 1.0, "atp_c": -1.0, "fgam_c": 1.0, "h_c": 1.0, "for_c": -1.0, "gar_c": -1.0, "pi_c": 1.0}, "id": "GART", "gene_reaction_rule": "ECS88_1905"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Gamma-butyrobetaine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GBBTNtex"]}, "metabolites": {"gbbtn_e": -1.0, "gbbtn_p": 1.0}, "id": "GBBTNtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Folate Metabolism", "name": "Glycolaldehyde dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GCALDD"]}, "metabolites": {"h2o_c": -1.0, "glyclt_c": 1.0, "h_c": 2.0, "nad_c": -1.0, "nadh_c": 1.0, "gcald_c": -1.0}, "id": "GCALDD", "gene_reaction_rule": "ECS88_1511"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "GDP-4-dehydro-6-deoxy-D-mannose epimerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GDMANE"]}, "metabolites": {"gdpddman_c": -1.0, "gdpofuc_c": 1.0}, "id": "GDMANE", "gene_reaction_rule": "ECS88_2149"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "GDP diphosphokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GDPDPK"]}, "metabolites": {"ppgpp_c": 1.0, "gdp_c": -1.0, "h_c": 1.0, "atp_c": -1.0, "amp_c": 1.0}, "id": "GDPDPK", "gene_reaction_rule": "ECS88_3052 or ECS88_4065"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "GDP-mannose mannosyl hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GDPMNH"]}, "metabolites": {"gdpmann_c": -1.0, "gdp_c": 1.0, "h_c": 1.0, "h2o_c": -1.0, "man_c": 1.0}, "id": "GDPMNH", "gene_reaction_rule": "ECS88_2148"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "GDP-mannose phyrophosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GDPMNP"]}, "metabolites": {"gdpmann_c": -1.0, "gmp_c": 1.0, "man1p_c": 1.0, "h_c": 2.0, "h2o_c": -1.0}, "id": "GDPMNP", "gene_reaction_rule": "ECS88_2646"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Guanosine 3'-diphosphate 5'-triphosphate 3'-diphosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GDPTPDP"]}, "metabolites": {"gdptp_c": -1.0, "ppi_c": 1.0, "gtp_c": 1.0, "h2o_c": -1.0}, "id": "GDPTPDP", "gene_reaction_rule": "ECS88_4065"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "GDP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GDPtex"]}, "metabolites": {"gdp_e": -1.0, "gdp_p": 1.0}, "id": "GDPtex", "gene_reaction_rule": "ECS88_1492 or ECS88_2364 or ECS88_0957 or ECS88_0276"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Glutamine-fructose-6-phosphate transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GF6PTA"]}, "metabolites": {"glu__L_c": 1.0, "f6p_c": -1.0, "gam6p_c": 1.0, "gln__L_c": -1.0}, "id": "GF6PTA", "gene_reaction_rule": "ECS88_4151"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Gamma-hydroxybutyrate dehydrogenase (NADH)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GHBDHx"]}, "metabolites": {"nad_c": 1.0, "sucsal_c": -1.0, "nadh_c": -1.0, "h_c": -1.0, "ghb_c": 1.0}, "id": "GHBDHx", "gene_reaction_rule": "ECS88_4324"}, {"subsystem": "Glycine and Serine Metabolism", "name": "Glycine hydroxymethyltransferase, reversible", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GHMT2r"]}, "metabolites": {"h2o_c": 1.0, "ser__L_c": -1.0, "thf_c": -1.0, "mlthf_c": 1.0, "gly_c": 1.0}, "id": "GHMT2r", "gene_reaction_rule": "ECS88_2721"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Guanylate kinase (GMP:ATP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GK1"]}, "metabolites": {"gmp_c": -1.0, "gdp_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "GK1", "gene_reaction_rule": "ECS88_4063"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "1,4-alpha-glucan branching enzyme (glycogen -> bglycogen)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLBRAN2"]}, "metabolites": {"bglycogen_c": 1.0, "glycogen_c": -1.0}, "id": "GLBRAN2", "gene_reaction_rule": "ECS88_3830"}, {"subsystem": "Alternate Carbon Metabolism", "name": "D-glucose O-acetyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCATr"]}, "metabolites": {"glc__D_c": -1.0, "acglc__D_c": 1.0, "coa_c": 1.0, "accoa_c": -1.0}, "id": "GLCATr", "gene_reaction_rule": "ECS88_0456"}, {"subsystem": "Oxidative Phosphorylation", "name": "Glucose dehydrogenase (ubiquinone-8 as acceptor) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCDpp"]}, "metabolites": {"glcn_p": 1.0, "h_p": 1.0, "q8h2_c": 1.0, "glc__D_p": -1.0, "h2o_p": -1.0, "q8_c": -1.0}, "id": "GLCDpp", "gene_reaction_rule": "ECS88_0133 or ECS88_0854"}, {"subsystem": "Transport, Inner Membrane", "name": "D-gluconate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCNt2rpp"]}, "metabolites": {"glcn_p": -1.0, "glcn_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GLCNt2rpp", "gene_reaction_rule": "ECS88_4939 or ECS88_3833 or ECS88_3804"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-gluconate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCNtex"]}, "metabolites": {"glcn_p": 1.0, "glcn_e": -1.0}, "id": "GLCNtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Glycogen phosphorylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCP"]}, "metabolites": {"pi_c": -1.0, "glycogen_c": -1.0, "g1p_c": 1.0}, "id": "GLCP", "gene_reaction_rule": "ECS88_3806"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Glycogen phosphorylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCP2"]}, "metabolites": {"bglycogen_c": -1.0, "pi_c": -1.0, "g1p_c": 1.0}, "id": "GLCP2", "gene_reaction_rule": "ECS88_3806"}, {"subsystem": "Alternate Carbon Metabolism", "name": "5-dehydro-4-deoxyglucarate aldolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCRAL"]}, "metabolites": {"pyr_c": 1.0, "5dh4dglc_c": -1.0, "2h3oppan_c": 1.0}, "id": "GLCRAL", "gene_reaction_rule": "ECS88_3514"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glucarate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCRD"]}, "metabolites": {"h2o_c": 1.0, "5dh4dglc_c": 1.0, "glcr_c": -1.0}, "id": "GLCRD", "gene_reaction_rule": "ECS88_3056 or ECS88_3055"}, {"subsystem": "Transport, Inner Membrane", "name": "D-glucarate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCRt2rpp"]}, "metabolites": {"h_c": 1.0, "glcr_p": -1.0, "h_p": -1.0, "glcr_c": 1.0}, "id": "GLCRt2rpp", "gene_reaction_rule": "ECS88_3515 or ECS88_3057"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-glucarate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCRtex"]}, "metabolites": {"glcr_e": -1.0, "glcr_p": 1.0}, "id": "GLCRtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Glycogen synthase (ADPGlc)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCS1"]}, "metabolites": {"adp_c": 1.0, "h_c": 1.0, "glycogen_c": 1.0, "adpglc_c": -1.0}, "id": "GLCS1", "gene_reaction_rule": "ECS88_3827"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Glucosyltransferase I (LPS core synthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCTR1"]}, "metabolites": {"icolipa_c": -1.0, "udp_c": 1.0, "udpg_c": -1.0, "h_c": 1.0, "gicolipa_c": 1.0}, "id": "GLCTR1", "gene_reaction_rule": "ECS88_4045"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-glucuronate 1-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCUR1Ptex"]}, "metabolites": {"glcur1p_p": 1.0, "glcur1p_e": -1.0}, "id": "GLCUR1Ptex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "D-glucuronate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCURt2rpp"]}, "metabolites": {"glcur_c": 1.0, "h_c": 1.0, "h_p": -1.0, "glcur_p": -1.0}, "id": "GLCURt2rpp", "gene_reaction_rule": "ECS88_4359 or ECS88_3489"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-glucuronat transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCURtex"]}, "metabolites": {"glcur_e": -1.0, "glcur_p": 1.0}, "id": "GLCURtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "D-glucose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "glc__D_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "glc__D_c": 1.0, "pi_c": 1.0}, "id": "GLCabcpp", "gene_reaction_rule": "ECS88_2295 and ECS88_2296 and ECS88_2294"}, {"subsystem": "Transport, Inner Membrane", "name": "D-glucose transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCptspp"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "glc__D_p": -1.0, "g6p_c": 1.0}, "id": "GLCptspp", "gene_reaction_rule": "(ECS88_2607 and ECS88_1668 and ECS88_2605 and ECS88_2606) or (ECS88_2607 and ECS88_1115 and ECS88_2605 and ECS88_2606) or (ECS88_1869 and ECS88_1870 and ECS88_1871 and ECS88_2605 and ECS88_2606)"}, {"subsystem": "Transport, Inner Membrane", "name": "D-glucose transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCt2pp"]}, "metabolites": {"glc__D_c": 1.0, "glc__D_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GLCt2pp", "gene_reaction_rule": "ECS88_3225"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glucose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCtex", "GLCtexi"]}, "metabolites": {"glc__D_p": 1.0, "glc__D_e": -1.0}, "id": "GLCtex_copy1", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Outer Membrane", "name": "Glucose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCtex", "GLCtexi"]}, "metabolites": {"glc__D_p": 1.0, "glc__D_e": -1.0}, "id": "GLCtex_copy2", "gene_reaction_rule": "ECS88_4510"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Glycogen debranching enzyme (bglycogen -> glycogen)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLDBRAN2"]}, "metabolites": {"bglycogen_c": -1.0, "glycogen_c": 1.0}, "id": "GLDBRAN2", "gene_reaction_rule": "ECS88_3829"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Glucose-1-phosphate adenylyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLGC"]}, "metabolites": {"h_c": -1.0, "ppi_c": 1.0, "adpglc_c": 1.0, "atp_c": -1.0, "g1p_c": -1.0}, "id": "GLGC", "gene_reaction_rule": "ECS88_3828"}, {"subsystem": "Glutamate Metabolism", "name": "Glutamine synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLNS"]}, "metabolites": {"atp_c": -1.0, "glu__L_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "nh4_c": -1.0, "gln__L_c": 1.0}, "id": "GLNS", "gene_reaction_rule": "ECS88_4320"}, {"subsystem": "tRNA Charging", "name": "Glutaminyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLNTRS"]}, "metabolites": {"glntrna_c": 1.0, "atp_c": -1.0, "trnagln_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "gln__L_c": -1.0}, "id": "GLNTRS", "gene_reaction_rule": "ECS88_0716"}, {"subsystem": "Transport, Inner Membrane", "name": "L-glutamine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLNabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "gln__L_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "gln__L_c": 1.0}, "id": "GLNabcpp", "gene_reaction_rule": "ECS88_0829 and ECS88_0828 and ECS88_0827"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-glutamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLNtex"]}, "metabolites": {"gln__L_e": -1.0, "gln__L_p": 1.0}, "id": "GLNtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Galactitol-1-phosphate dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLTPD"]}, "metabolites": {"nadh_c": 1.0, "tag6p__D_c": 1.0, "galt1p_c": -1.0, "nad_c": -1.0, "h_c": 1.0}, "id": "GLTPD", "gene_reaction_rule": "ECS88_2233"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Glutamate 5-kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLU5K"]}, "metabolites": {"glu__L_c": -1.0, "glu5p_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "GLU5K", "gene_reaction_rule": "ECS88_0277"}, {"subsystem": "Transport, Inner Membrane", "name": "4-aminobutyrate/glutamate antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLUABUTt7pp"]}, "metabolites": {"glu__L_p": -1.0, "glu__L_c": 1.0, "4abut_p": 1.0, "4abut_c": -1.0}, "id": "GLUABUTt7pp", "gene_reaction_rule": "ECS88_1580"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Gamma-glutamylcysteine synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUCYS"]}, "metabolites": {"cys__L_c": -1.0, "glucys_c": 1.0, "atp_c": -1.0, "glu__L_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "GLUCYS", "gene_reaction_rule": "ECS88_2955"}, {"subsystem": "Glutamate Metabolism", "name": "Glutamate Decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUDC"]}, "metabolites": {"glu__L_c": -1.0, "co2_c": 1.0, "h_c": -1.0, "4abut_c": 1.0}, "id": "GLUDC", "gene_reaction_rule": "ECS88_1581"}, {"subsystem": "Glutamate Metabolism", "name": "Glutamate dehydrogenase (NADP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLUDy"]}, "metabolites": {"akg_c": 1.0, "h2o_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "glu__L_c": -1.0, "h_c": 1.0, "nh4_c": 1.0}, "id": "GLUDy", "gene_reaction_rule": "ECS88_1812"}, {"subsystem": "Glutamate Metabolism", "name": "Glutaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUN"]}, "metabolites": {"h2o_c": -1.0, "glu__L_c": 1.0, "nh4_c": 1.0, "gln__L_c": -1.0}, "id": "GLUN", "gene_reaction_rule": "ECS88_1864 or ECS88_0486 or ECS88_1601"}, {"subsystem": "Glutamate Metabolism", "name": "Glutaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUNpp"]}, "metabolites": {"glu__L_p": 1.0, "gln__L_p": -1.0, "nh4_p": 1.0, "h2o_p": -1.0}, "id": "GLUNpp", "gene_reaction_rule": "ECS88_3239"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Glutamine phosphoribosyldiphosphate amidotransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUPRT"]}, "metabolites": {"pram_c": 1.0, "h2o_c": -1.0, "ppi_c": 1.0, "glu__L_c": 1.0, "prpp_c": -1.0, "gln__L_c": -1.0}, "id": "GLUPRT", "gene_reaction_rule": "ECS88_2459"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Glutamate racemase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLUR"]}, "metabolites": {"glu__D_c": -1.0, "glu__L_c": 1.0}, "id": "GLUR", "gene_reaction_rule": "ECS88_4426"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Glutamyl-tRNA reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUTRR"]}, "metabolites": {"nadp_c": 1.0, "nadph_c": -1.0, "glu1sa_c": 1.0, "trnaglu_c": 1.0, "h_c": -1.0, "glutrna_c": -1.0}, "id": "GLUTRR", "gene_reaction_rule": "ECS88_1278"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Glutamyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUTRS"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "trnaglu_c": -1.0, "amp_c": 1.0, "glutrna_c": 1.0, "glu__L_c": -1.0}, "id": "GLUTRS", "gene_reaction_rule": "ECS88_2592"}, {"subsystem": "Transport, Inner Membrane", "name": "L-glutamate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "glu__L_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "glu__L_p": -1.0, "pi_c": 1.0}, "id": "GLUabcpp", "gene_reaction_rule": "ECS88_0690 and ECS88_0689 and ECS88_0688 and ECS88_0687"}, {"subsystem": "Transport, Inner Membrane", "name": "L-glutamate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLUt2rpp"]}, "metabolites": {"glu__L_p": -1.0, "glu__L_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GLUt2rpp", "gene_reaction_rule": "ECS88_4570"}, {"subsystem": "Transport, Inner Membrane", "name": "Na+/glutamate symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUt4pp"]}, "metabolites": {"na1_p": -1.0, "glu__L_p": -1.0, "glu__L_c": 1.0, "na1_c": 1.0}, "id": "GLUt4pp", "gene_reaction_rule": "ECS88_4068"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-glutamate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLUtex"]}, "metabolites": {"glu__L_p": 1.0, "glu__L_e": -1.0}, "id": "GLUtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Glyoxylate Metabolism", "name": "Glyoxalate carboligase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLXCL"]}, "metabolites": {"co2_c": 1.0, "glx_c": -2.0, "h_c": -1.0, "2h3oppan_c": 1.0}, "id": "GLXCL", "gene_reaction_rule": "ECS88_0506"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glyceraldehyde transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYALDtex"]}, "metabolites": {"glyald_e": -1.0, "glyald_p": 1.0}, "id": "GLYALDtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "Glyceraldehyde facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYALDtpp"]}, "metabolites": {"glyald_c": 1.0, "glyald_p": -1.0}, "id": "GLYALDtpp", "gene_reaction_rule": "ECS88_4377"}, {"subsystem": "Glycine and Serine Metabolism", "name": "Glycine C-acetyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYAT"]}, "metabolites": {"coa_c": 1.0, "2aobut_c": 1.0, "accoa_c": -1.0, "gly_c": -1.0}, "id": "GLYAT", "gene_reaction_rule": "ECS88_4034"}, {"subsystem": "Transport, Inner Membrane", "name": "Glycine betaine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYBabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "glyb_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "glyb_p": -1.0}, "id": "GLYBabcpp", "gene_reaction_rule": "ECS88_2272 and ECS88_2273 and ECS88_2274 and ECS88_2275"}, {"subsystem": "Transport, Inner Membrane", "name": "Glycine betaine transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYBt2pp", "GLYBt6pp"]}, "metabolites": {"glyb_c": 1.0, "h_c": 1.0, "h_p": -1.0, "glyb_p": -1.0}, "id": "GLYBt2pp_copy1", "gene_reaction_rule": "ECS88_4612"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glycine betaine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYBtex"]}, "metabolites": {"glyb_e": -1.0, "glyb_p": 1.0}, "id": "GLYBtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "Sn-Glycerol 2-phosphate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYC2Pabcpp"]}, "metabolites": {"h2o_c": -1.0, "glyc2p_c": 1.0, "atp_c": -1.0, "adp_c": 1.0, "h_c": 1.0, "glyc2p_p": -1.0, "pi_c": 1.0}, "id": "GLYC2Pabcpp", "gene_reaction_rule": "ECS88_3849 and ECS88_3850 and ECS88_3847 and ECS88_3848"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glycerol-2-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYC2Ptex"]}, "metabolites": {"glyc2p_e": -1.0, "glyc2p_p": 1.0}, "id": "GLYC2Ptex", "gene_reaction_rule": "ECS88_2364 or ECS88_0276 or ECS88_0957 or ECS88_1492"}, {"subsystem": "Transport, Inner Membrane", "name": "Sn-Glycerol 3-phosphate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYC3Pabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "glyc3p_c": 1.0, "glyc3p_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "GLYC3Pabcpp", "gene_reaction_rule": "ECS88_3849 and ECS88_3850 and ECS88_3847 and ECS88_3848"}, {"subsystem": "Transport, Inner Membrane", "name": "Glycerol-3-phosphate : phosphate antiporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYC3Pt6pp"]}, "metabolites": {"pi_p": 1.0, "glyc3p_p": -1.0, "glyc3p_c": 1.0, "pi_c": -1.0}, "id": "GLYC3Pt6pp", "gene_reaction_rule": "ECS88_2387"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glycerol-3-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYC3Ptex"]}, "metabolites": {"glyc3p_p": 1.0, "glyc3p_e": -1.0}, "id": "GLYC3Ptex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "D-glycerate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYCAt2rpp"]}, "metabolites": {"glyc__R_c": 1.0, "h_c": 1.0, "h_p": -1.0, "glyc__R_p": -1.0}, "id": "GLYCAt2rpp", "gene_reaction_rule": "ECS88_3057 or ECS88_3515"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-glycerate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYCAtex"]}, "metabolites": {"glyc__R_e": -1.0, "glyc__R_p": 1.0}, "id": "GLYCAtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glycerol dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCDx"]}, "metabolites": {"nad_c": -1.0, "nadh_c": 1.0, "h_c": 1.0, "dha_c": 1.0, "glyc_c": -1.0}, "id": "GLYCDx", "gene_reaction_rule": "ECS88_4401"}, {"subsystem": "Glyoxylate Metabolism", "name": "Glycerate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCK"]}, "metabolites": {"3pg_c": 1.0, "glyc__R_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "GLYCK", "gene_reaction_rule": "ECS88_0513"}, {"subsystem": "Glycine and Serine Metabolism", "name": "Glycerate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCK2"]}, "metabolites": {"h_c": 1.0, "glyc__R_c": -1.0, "2pg_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "GLYCK2", "gene_reaction_rule": "ECS88_3512"}, {"subsystem": "Folate Metabolism", "name": "Glycine Cleavage System", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCL"]}, "metabolites": {"co2_c": 1.0, "mlthf_c": 1.0, "gly_c": -1.0, "thf_c": -1.0, "nad_c": -1.0, "nadh_c": 1.0, "nh4_c": 1.0}, "id": "GLYCL", "gene_reaction_rule": "ECS88_3183 and ECS88_3182 and ECS88_3184 and ECS88_0125"}, {"subsystem": "Glyoxylate Metabolism", "name": "Glycolate dehydrogenase (NAD)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCLTDx"]}, "metabolites": {"glyclt_c": 1.0, "glx_c": -1.0, "nadh_c": -1.0, "nad_c": 1.0, "h_c": -1.0}, "id": "GLYCLTDx", "gene_reaction_rule": "ECS88_3972 or ECS88_1044"}, {"subsystem": "Glyoxylate Metabolism", "name": "Glycolate dehydrogenase (NADP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCLTDy"]}, "metabolites": {"glx_c": -1.0, "glyclt_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "nadp_c": 1.0}, "id": "GLYCLTDy", "gene_reaction_rule": "ECS88_1044 or ECS88_3972"}, {"subsystem": "Transport, Inner Membrane", "name": "Glycolate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYCLTt2rpp"]}, "metabolites": {"glyclt_p": -1.0, "glyclt_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GLYCLTt2rpp", "gene_reaction_rule": "ECS88_3349"}, {"subsystem": "Transport, Inner Membrane", "name": "Glycolate transport via sodium symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCLTt4pp"]}, "metabolites": {"glyclt_p": -1.0, "glyclt_c": 1.0, "na1_c": 1.0, "na1_p": -1.0}, "id": "GLYCLTt4pp", "gene_reaction_rule": "ECS88_4560"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glycolate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYCLTtex"]}, "metabolites": {"glyclt_p": 1.0, "glyclt_e": -1.0}, "id": "GLYCLTtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glycolate oxidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCTO2"]}, "metabolites": {"q8h2_c": 1.0, "glyclt_c": -1.0, "glx_c": 1.0, "q8_c": -1.0}, "id": "GLYCTO2", "gene_reaction_rule": "ECS88_3354 and ECS88_3352 and ECS88_3353"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glycolate oxidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCTO3"]}, "metabolites": {"glx_c": 1.0, "glyclt_c": -1.0, "mqn8_c": -1.0, "mql8_c": 1.0}, "id": "GLYCTO3", "gene_reaction_rule": "ECS88_3354 and ECS88_3352 and ECS88_3353"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glycolate oxidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCTO4"]}, "metabolites": {"glyclt_c": -1.0, "glx_c": 1.0, "2dmmq8_c": -1.0, "2dmmql8_c": 1.0}, "id": "GLYCTO4", "gene_reaction_rule": "ECS88_3354 and ECS88_3352 and ECS88_3353"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glycerol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYCtex"]}, "metabolites": {"glyc_e": -1.0, "glyc_p": 1.0}, "id": "GLYCtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "Glycerol transport via channel (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYCtpp"]}, "metabolites": {"glyc_c": -1.0, "glyc_p": 1.0}, "id": "GLYCtpp", "gene_reaction_rule": "ECS88_4377 or s0001"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glycerol kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYK"]}, "metabolites": {"glyc3p_c": 1.0, "glyc_c": -1.0, "adp_c": 1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "GLYK", "gene_reaction_rule": "ECS88_4376"}, {"subsystem": "Methylglyoxal Metabolism", "name": "Hydroxyacylglutathione hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYOX"]}, "metabolites": {"gthrd_c": 1.0, "h2o_c": -1.0, "lac__D_c": 1.0, "h_c": 1.0, "lgt__S_c": -1.0}, "id": "GLYOX", "gene_reaction_rule": "ECS88_0227"}, {"subsystem": "Methylglyoxal Metabolism", "name": "Glyoxalase III", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYOX3"]}, "metabolites": {"h2o_c": -1.0, "lac__D_c": 1.0, "h_c": 1.0, "mthgxl_c": -1.0}, "id": "GLYOX3", "gene_reaction_rule": ""}, {"subsystem": "tRNA Charging", "name": "Glycyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYTRS"]}, "metabolites": {"glytrna_c": 1.0, "atp_c": -1.0, "ppi_c": 1.0, "trnagly_c": -1.0, "amp_c": 1.0, "gly_c": -1.0}, "id": "GLYTRS", "gene_reaction_rule": "ECS88_3976 and ECS88_3977"}, {"subsystem": "Transport, Inner Membrane", "name": "Glycine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYt2pp", "GLYt2rpp"]}, "metabolites": {"gly_p": -1.0, "gly_c": 1.0, "h_p": -1.0, "h_c": 1.0}, "id": "GLYt2pp_copy1", "gene_reaction_rule": "ECS88_4802"}, {"subsystem": "Transport, Inner Membrane", "name": "Glycine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYt2pp", "GLYt2rpp"]}, "metabolites": {"gly_p": -1.0, "gly_c": 1.0, "h_p": -1.0, "h_c": 1.0}, "id": "GLYt2pp_copy2", "gene_reaction_rule": ""}, {"subsystem": "Transport, Inner Membrane", "name": "Glycine transport in via sodium symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYt4pp"]}, "metabolites": {"na1_p": -1.0, "na1_c": 1.0, "gly_c": 1.0, "gly_p": -1.0}, "id": "GLYt4pp", "gene_reaction_rule": "ECS88_0007"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glycine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYtex"]}, "metabolites": {"gly_e": -1.0, "gly_p": 1.0}, "id": "GLYtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "GDP-D-mannose dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GMAND"]}, "metabolites": {"h2o_c": 1.0, "gdpddman_c": 1.0, "gdpmann_c": -1.0}, "id": "GMAND", "gene_reaction_rule": "ECS88_2150"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "D-glycero-D-manno-hepose 1-phosphate adenyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GMHEPAT"]}, "metabolites": {"ppi_c": 1.0, "gmhep1p_c": -1.0, "adphep_DD_c": 1.0, "h_c": -1.0, "atp_c": -1.0}, "id": "GMHEPAT", "gene_reaction_rule": "ECS88_3449"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "D-glycero-D-manno-heptose 7-phosphate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GMHEPK"]}, "metabolites": {"adp_c": 1.0, "gmhep17bp_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "gmhep7p_c": -1.0}, "id": "GMHEPK", "gene_reaction_rule": "ECS88_3449"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GMHEPPA"]}, "metabolites": {"gmhep1p_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0, "gmhep17bp_c": -1.0}, "id": "GMHEPPA", "gene_reaction_rule": "ECS88_0212"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "GMP reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GMPR"]}, "metabolites": {"nadp_c": 1.0, "nadph_c": -1.0, "imp_c": 1.0, "gmp_c": -1.0, "h_c": -2.0, "nh4_c": 1.0}, "id": "GMPR", "gene_reaction_rule": "ECS88_0107"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "GMP synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GMPS2"]}, "metabolites": {"xmp_c": -1.0, "h2o_c": -1.0, "gmp_c": 1.0, "atp_c": -1.0, "h_c": 2.0, "glu__L_c": 1.0, "amp_c": 1.0, "ppi_c": 1.0, "gln__L_c": -1.0}, "id": "GMPS2", "gene_reaction_rule": "ECS88_2679"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "GMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GMPtex"]}, "metabolites": {"gmp_p": 1.0, "gmp_e": -1.0}, "id": "GMPtex", "gene_reaction_rule": "ECS88_1492 or ECS88_2364 or ECS88_0276 or ECS88_0957"}, {"subsystem": "Pentose Phosphate Pathway", "name": "Phosphogluconate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GND"]}, "metabolites": {"6pgc_c": -1.0, "co2_c": 1.0, "nadph_c": 1.0, "ru5p__D_c": 1.0, "nadp_c": -1.0}, "id": "GND", "gene_reaction_rule": "ECS88_2128"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Gluconokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GNK"]}, "metabolites": {"6pgc_c": 1.0, "glcn_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "GNK", "gene_reaction_rule": "ECS88_3834"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "GDP-4-oxo-L-fucose reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GOFUCR"]}, "metabolites": {"gdpfuc_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "gdpofuc_c": -1.0}, "id": "GOFUCR", "gene_reaction_rule": "ECS88_2149"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Gp4G hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GP4GH"]}, "metabolites": {"gp4g_c": -1.0, "gdp_c": 2.0, "h_c": 2.0, "h2o_c": -1.0}, "id": "GP4GH", "gene_reaction_rule": "ECS88_0054"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GPDDA1"]}, "metabolites": {"chol_c": 1.0, "glyc3p_c": 1.0, "h_c": 1.0, "h2o_c": -1.0, "g3pc_c": -1.0}, "id": "GPDDA1", "gene_reaction_rule": "ECS88_3846"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GPDDA1pp"]}, "metabolites": {"glyc3p_p": 1.0, "chol_p": 1.0, "g3pc_p": -1.0, "h_p": 1.0, "h2o_p": -1.0}, "id": "GPDDA1pp", "gene_reaction_rule": "ECS88_2386"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerophosphodiester phosphodiesterase (Glycerophosphoethanolamine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GPDDA2"]}, "metabolites": {"glyc3p_c": 1.0, "h2o_c": -1.0, "h_c": 1.0, "etha_c": 1.0, "g3pe_c": -1.0}, "id": "GPDDA2", "gene_reaction_rule": "ECS88_3846"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerophosphodiester phosphodiesterase (Glycerophosphoethanolamine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GPDDA2pp"]}, "metabolites": {"glyc3p_p": 1.0, "g3pe_p": -1.0, "etha_p": 1.0, "h_p": 1.0, "h2o_p": -1.0}, "id": "GPDDA2pp", "gene_reaction_rule": "ECS88_2386"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerophosphodiester phosphodiesterase (Glycerophosphoserine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GPDDA3"]}, "metabolites": {"glyc3p_c": 1.0, "ser__L_c": 1.0, "h_c": 1.0, "h2o_c": -1.0, "g3ps_c": -1.0}, "id": "GPDDA3", "gene_reaction_rule": "ECS88_3846"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerophosphodiester phosphodiesterase (Glycerophosphoserine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GPDDA3pp"]}, "metabolites": {"g3ps_p": -1.0, "glyc3p_p": 1.0, "ser__L_p": 1.0, "h_p": 1.0, "h2o_p": -1.0}, "id": "GPDDA3pp", "gene_reaction_rule": "ECS88_2386"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerophosphodiester phosphodiesterase (Glycerophosphoglycerol)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GPDDA4"]}, "metabolites": {"g3pg_c": -1.0, "glyc3p_c": 1.0, "h_c": 1.0, "h2o_c": -1.0, "glyc_c": 1.0}, "id": "GPDDA4", "gene_reaction_rule": "ECS88_3846"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerophosphodiester phosphodiesterase (Glycerophosphoglycerol)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GPDDA4pp"]}, "metabolites": {"h2o_p": -1.0, "g3pg_p": -1.0, "glyc_p": 1.0, "h_p": 1.0, "glyc3p_p": 1.0}, "id": "GPDDA4pp", "gene_reaction_rule": "ECS88_2386"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerophosphodiester phosphodiesterase (Glycerophosphoinositol)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GPDDA5"]}, "metabolites": {"glyc3p_c": 1.0, "g3pi_c": -1.0, "inost_c": 1.0, "h_c": 1.0, "h2o_c": -1.0}, "id": "GPDDA5", "gene_reaction_rule": "ECS88_3846"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerophosphodiester phosphodiesterase (Glycerophosphoinositol)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GPDDA5pp"]}, "metabolites": {"g3pi_p": -1.0, "h2o_p": -1.0, "glyc3p_p": 1.0, "h_p": 1.0, "inost_p": 1.0}, "id": "GPDDA5pp", "gene_reaction_rule": "ECS88_2386"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Geranyltranstransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GRTT"]}, "metabolites": {"ppi_c": 1.0, "ipdp_c": -1.0, "frdp_c": 1.0, "grdp_c": -1.0}, "id": "GRTT", "gene_reaction_rule": "ECS88_0416"}, {"subsystem": "Unassigned", "name": "Glutaredoxin reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GRXR"]}, "metabolites": {"grxox_c": -1.0, "gthrd_c": -2.0, "grxrd_c": 1.0, "gthox_c": 1.0}, "id": "GRXR", "gene_reaction_rule": "ECS88_1078 or ECS88_4027 or ECS88_1703 or ECS88_0866"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Guanosine kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GSNK"]}, "metabolites": {"gmp_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "gsn_c": -1.0}, "id": "GSNK", "gene_reaction_rule": "ECS88_0474"}, {"subsystem": "Transport, Inner Membrane", "name": "Guanosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GSNt2pp"]}, "metabolites": {"gsn_p": -1.0, "h_c": 1.0, "h_p": -1.0, "gsn_c": 1.0}, "id": "GSNt2pp", "gene_reaction_rule": "ECS88_3247"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Guanosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GSNtex"]}, "metabolites": {"gsn_e": -1.0, "gsn_p": 1.0}, "id": "GSNtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Glutathionylspermidine amidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GSPMDA"]}, "metabolites": {"gtspmd_c": -1.0, "h2o_c": -1.0, "gthrd_c": 1.0, "spmd_c": 1.0}, "id": "GSPMDA", "gene_reaction_rule": "ECS88_3370"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Glutathionylspermidine synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, 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1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GTHPi", "GSHPO"]}, "metabolites": {"h2o2_c": -1.0, "h2o_c": 2.0, "gthrd_c": -2.0, "gthox_c": 1.0}, "id": "GTHPi_copy1", "gene_reaction_rule": "ECS88_1761"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Glutathione hydralase (periplasmic)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GTHRDHpp"]}, "metabolites": {"h2o_p": -1.0, "glu__L_p": 1.0, "cgly_p": 1.0, "gthrd_p": -1.0}, "id": "GTHRDHpp", "gene_reaction_rule": "ECS88_3844"}, {"subsystem": "Transport, Inner Membrane", "name": "Glutathione export via ABC system (cytoplasm to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GTHRDabc2pp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "gthrd_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "gthrd_c": -1.0}, "id": "GTHRDabc2pp", "gene_reaction_rule": "ECS88_0915 and ECS88_0916"}, {"subsystem": "Transport, Inner Membrane", "name": "Reduced glutathione via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GTHRDabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "gthrd_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "gthrd_c": 1.0}, "id": "GTHRDabcpp", "gene_reaction_rule": "ECS88_0846 and ECS88_0847 and ECS88_0848 and ECS88_0849"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glutathione transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GTHRDtex"]}, "metabolites": {"gthrd_e": -1.0, "gthrd_p": 1.0}, "id": "GTHRDtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Glutathione synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GTHS"]}, "metabolites": {"glucys_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, 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"gdptp_c": -1.0, "pi_c": 1.0, "h_c": 1.0, "ppgpp_c": 1.0}, "id": "GTPDPDP", "gene_reaction_rule": "ECS88_4200"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "GTP diphosphokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GTPDPK"]}, "metabolites": {"gdptp_c": 1.0, "gtp_c": -1.0, "amp_c": 1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "GTPDPK", "gene_reaction_rule": "ECS88_3052"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "GTP amine hydrolysis (spontaneous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GTPHs"]}, "metabolites": {"h2o_c": -1.0, "nh4_c": 1.0, "gtp_c": -1.0, "h_c": -1.0, "xtp_c": 1.0}, "id": "GTPHs", "gene_reaction_rule": "s0001"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "GTP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GTPtex"]}, "metabolites": {"gtp_e": -1.0, "gtp_p": 1.0}, "id": "GTPtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Guanylate cyclase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GUACYC"]}, "metabolites": {"ppi_c": 1.0, "gtp_c": -1.0, "35cgmp_c": 1.0}, "id": "GUACYC", "gene_reaction_rule": ""}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Guanine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GUAD"]}, "metabolites": {"xan_c": 1.0, "gua_c": -1.0, "h_c": -1.0, "h2o_c": -1.0, "nh4_c": 1.0}, "id": "GUAD", "gene_reaction_rule": "ECS88_3162"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Guanine phosphoribosyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GUAPRT"]}, "metabolites": {"ppi_c": 1.0, "gmp_c": 1.0, "gua_c": -1.0, "prpp_c": -1.0}, "id": "GUAPRT", "gene_reaction_rule": "ECS88_0273 or ECS88_0134"}, {"subsystem": "Transport, Inner Membrane", "name": "Guanine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GUAt2pp"]}, "metabolites": {"gua_p": -1.0, "gua_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GUAt2pp", "gene_reaction_rule": "ECS88_4070"}, {"subsystem": "Transport, Outer Membrane", "name": "Guanine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GUAtex"]}, "metabolites": {"gua_p": 1.0, "gua_e": -1.0}, "id": "GUAtex", "gene_reaction_rule": "ECS88_0406"}, {"subsystem": "Transport, Inner Membrane", "name": "Guanine transport via diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GUAtpp"]}, "metabolites": {"gua_p": -1.0, "gua_c": 1.0}, "id": "GUAtpp", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glucuronate isomerase (D-glucuronate)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GUI1"]}, "metabolites": {"glcur_c": -1.0, "fruur_c": 1.0}, "id": "GUI1", "gene_reaction_rule": "ECS88_3488"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glucuronate isomerase (D-galacturonate)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GUI2"]}, "metabolites": {"galur_c": -1.0, "tagur_c": 1.0}, "id": "GUI2", "gene_reaction_rule": "ECS88_3488"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glucuronate 1-phosphate phosphatase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GUR1PPpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "glcur1p_p": -1.0, "glcur_p": 1.0}, "id": "GUR1PPpp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Hydrogen peroxide transport via diffusion (external)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["H2O2tex"]}, "metabolites": {"h2o2_p": 1.0, "h2o2_e": -1.0}, "id": "H2O2tex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "H2O transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["H2Otex"]}, "metabolites": {"h2o_p": 1.0, "h2o_e": -1.0}, "id": "H2Otex", "gene_reaction_rule": "s0001 or ECS88_0978 or ECS88_2364 or ECS88_0276 or ECS88_1461 or ECS88_1492 or ECS88_0957"}, {"subsystem": "Transport, Inner Membrane", "name": "H2O transport via diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["H2Otpp"]}, "metabolites": {"h2o_p": -1.0, "h2o_c": 1.0}, "id": "H2Otpp", "gene_reaction_rule": "s0001 or ECS88_0897"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Hydrogen sulfide oxidation", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["H2SO"]}, "metabolites": {"so4_c": 1.0, "h_c": 2.0, "h2s_c": -1.0, "o2_c": -2.0}, "id": "H2SO", "gene_reaction_rule": ""}, {"subsystem": "Transport, Inner Membrane", "name": "H2s transport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["H2St1pp"]}, "metabolites": {"h2s_p": 1.0, "h2s_c": -1.0}, "id": "H2St1pp", "gene_reaction_rule": "s0001"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "H2s transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["H2Stex"]}, "metabolites": {"h2s_e": -1.0, "h2s_p": 1.0}, "id": "H2Stex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Hydrogen transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["H2tex"]}, "metabolites": {"h2_e": -1.0, "h2_p": 1.0}, "id": "H2tex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "Hydrogen transport diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["H2tpp"]}, "metabolites": {"h2_c": 1.0, "h2_p": -1.0}, "id": "H2tpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HACD1"]}, "metabolites": {"aacoa_c": -1.0, "3hbcoa_c": 1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0}, "id": "HACD1", "gene_reaction_rule": "ECS88_4294 or ECS88_2488"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxohexanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HACD2"]}, "metabolites": {"3hhcoa_c": 1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "3ohcoa_c": -1.0}, 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"HCO3 equilibration reaction", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HCO3E"]}, "metabolites": {"hco3_c": 1.0, "h2o_c": -1.0, "co2_c": -1.0, "h_c": 1.0}, "id": "HCO3E", "gene_reaction_rule": "ECS88_0135"}, {"subsystem": "Transport, Outer Membrane", "name": "Hexadecanoate transport via facilitated irreversible diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HDCAtexi"]}, "metabolites": {"hdca_e": -1.0, "hdca_p": 1.0}, "id": "HDCAtexi", "gene_reaction_rule": "ECS88_2491"}, {"subsystem": "Transport, Outer Membrane", "name": "Hexadecenoate transport via facilitated irreversible diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HDCEAtexi"]}, "metabolites": {"hdcea_p": 1.0, "hdcea_e": -1.0}, "id": "HDCEAtexi", "gene_reaction_rule": "ECS88_2491"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Heme 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Recycling", "name": "Heptosyltransferase II (LPS core synthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEPT2"]}, "metabolites": {"hlipa_c": -1.0, "hhlipa_c": 1.0, "h_c": 1.0, "adphep_LD_c": -1.0, "adp_c": 1.0}, "id": "HEPT2", "gene_reaction_rule": "ECS88_4036"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Heptosyltransferase III (LPS core synthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEPT3"]}, "metabolites": {"hphhlipa_c": 1.0, "phhlipa_c": -1.0, "h_c": 1.0, "adphep_LD_c": -1.0, "adp_c": 1.0}, "id": "HEPT3", "gene_reaction_rule": "ECS88_4046"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Hydroxyethylthiazole kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HETZK"]}, "metabolites": {"4mpetz_c": 1.0, "4mhetz_c": -1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "HETZK", "gene_reaction_rule": "ECS88_2246"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Hexokinase (D-glucose:ATP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEX1"]}, "metabolites": {"glc__D_c": -1.0, "g6p_c": 1.0, "adp_c": 1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "HEX1", "gene_reaction_rule": "ECS88_2583"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Hexokinase (D-mannose:ATP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEX4"]}, "metabolites": {"adp_c": 1.0, "man6p_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "man_c": -1.0}, "id": "HEX4", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Hexokinase (D-fructose:ATP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEX7"]}, "metabolites": {"adp_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "fru_c": -1.0, "f6p_c": 1.0}, "id": "HEX7", "gene_reaction_rule": "ECS88_0389"}, {"subsystem": "Transport, Inner Membrane", "name": "Hexanoate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HEXt2rpp"]}, "metabolites": {"hxa_p": -1.0, "hxa_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "HEXt2rpp", "gene_reaction_rule": "ECS88_2372"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Mercury (Hg+2) ABC transporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HG2abcpp"]}, "metabolites": {"h2o_c": -1.0, "hg2_p": 1.0, "atp_c": -1.0, "hg2_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "HG2abcpp", "gene_reaction_rule": "ECS88_3872"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Mercury (Hg+2) transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HG2t3pp"]}, "metabolites": {"hg2_c": -1.0, "hg2_p": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "HG2t3pp", "gene_reaction_rule": "ECS88_4365"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Mercury (Hg+2) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HG2tex"]}, "metabolites": {"hg2_p": 1.0, "hg2_e": -1.0}, "id": "HG2tex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Histidine Metabolism", "name": "Histidinol dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HISTD"]}, "metabolites": {"histd_c": -1.0, "h2o_c": -1.0, "his__L_c": 1.0, "h_c": 3.0, "nad_c": -2.0, "nadh_c": 2.0}, "id": "HISTD", "gene_reaction_rule": "ECS88_2119"}, {"subsystem": "Histidine Metabolism", "name": "Histidinol-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HISTP"]}, "metabolites": {"hisp_c": -1.0, "histd_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0}, "id": "HISTP", "gene_reaction_rule": "ECS88_2121"}, {"subsystem": "tRNA Charging", "name": "Histidyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HISTRS"]}, "metabolites": {"histrna_c": 1.0, "atp_c": -1.0, "his__L_c": -1.0, "ppi_c": 1.0, "trnahis_c": -1.0, "amp_c": 1.0}, "id": "HISTRS", "gene_reaction_rule": "ECS88_2690"}, {"subsystem": "Transport, Inner Membrane", "name": "L-histidine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HISabcpp"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "atp_c": -1.0, "his__L_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "his__L_p": -1.0}, "id": "HISabcpp", "gene_reaction_rule": "ECS88_2456 and ECS88_2454 and ECS88_2453 and ECS88_2455"}, {"subsystem": "Transport, Inner Membrane", "name": "L-histidine reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HISt2rpp"]}, "metabolites": {"his__L_c": 1.0, "his__L_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "HISt2rpp", "gene_reaction_rule": "ECS88_0114"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-histidine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HIStex"]}, "metabolites": {"his__L_p": 1.0, "his__L_e": -1.0}, "id": "HIStex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Hydroxymethylbilane synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HMBS"]}, "metabolites": {"ppbng_c": -4.0, "hmbil_c": 1.0, "nh4_c": 4.0, "h2o_c": -1.0}, "id": "HMBS", "gene_reaction_rule": "ECS88_4227"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Hydroxymethylpyrimidine kinase (ATP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HMPK1"]}, "metabolites": {"adp_c": 1.0, "4ampm_c": 1.0, "4ahmmp_c": -1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "HMPK1", "gene_reaction_rule": "ECS88_2245 or ECS88_2608"}, {"subsystem": "Transport, Inner Membrane", "name": "L-homoserineserine efflux via proton symport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HOMt2pp"]}, "metabolites": {"hom__L_c": -1.0, "hom__L_p": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "HOMt2pp", "gene_reaction_rule": "ECS88_0831 or ECS88_4252"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-homoserine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HOMtex"]}, "metabolites": {"hom__L_p": 1.0, "hom__L_e": -1.0}, "id": "HOMtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "6-hydroxymethyl-dihydropterin pyrophosphokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HPPK2"]}, "metabolites": {"6hmhptpp_c": 1.0, "6hmhpt_c": -1.0, "h_c": 1.0, "atp_c": -1.0, "amp_c": 1.0}, "id": "HPPK2", "gene_reaction_rule": "ECS88_0152"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "3-(3-hydroxyphenyl)propionate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HPPPNtex"]}, "metabolites": {"3hpppn_e": -1.0, "3hpppn_p": 1.0}, "id": "HPPPNtex", "gene_reaction_rule": "ECS88_0957 or ECS88_1492 or ECS88_2364 or ECS88_0276"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Hydroxypyruvate isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HPYRI"]}, "metabolites": {"hpyr_c": -1.0, "2h3oppan_c": 1.0}, "id": "HPYRI", "gene_reaction_rule": "ECS88_0507"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Hydroxypyruvate reductase (NADH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HPYRRx"]}, "metabolites": {"hpyr_c": -1.0, "nadh_c": -1.0, "glyc__R_c": 1.0, "h_c": -1.0, "nad_c": 1.0}, "id": "HPYRRx", "gene_reaction_rule": "ECS88_1044 or ECS88_3972"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Hydroxypyruvate reductase (NADPH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HPYRRy"]}, "metabolites": {"hpyr_c": -1.0, "nadp_c": 1.0, "glyc__R_c": 1.0, "h_c": -1.0, "nadph_c": -1.0}, "id": "HPYRRy", "gene_reaction_rule": "ECS88_1044 or ECS88_3972"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Homoserine dehydrogenase (NADPH)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HSDy"]}, "metabolites": {"hom__L_c": -1.0, "aspsa_c": 1.0, "nadp_c": -1.0, "nadph_c": 1.0, "h_c": 1.0}, "id": "HSDy", "gene_reaction_rule": "ECS88_4391 or ECS88_0002"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Homoserine kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HSK"]}, "metabolites": {"hom__L_c": -1.0, "phom_c": 1.0, "adp_c": 1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "HSK", "gene_reaction_rule": "ECS88_0003"}, {"subsystem": "Methionine Metabolism", "name": "Homoserine O-succinyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HSST"]}, "metabolites": {"hom__L_c": -1.0, "succoa_c": -1.0, "suchms_c": 1.0, "coa_c": 1.0}, "id": "HSST", "gene_reaction_rule": "ECS88_4478"}, {"subsystem": "Histidine Metabolism", "name": "Histidinol-phosphate transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HSTPT"]}, "metabolites": {"hisp_c": 1.0, "akg_c": 1.0, "glu__L_c": -1.0, "imacp_c": -1.0}, "id": "HSTPT", "gene_reaction_rule": "ECS88_2120"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Hypoxanthine dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HXAND"]}, "metabolites": {"h2o_c": -1.0, "xan_c": 1.0, "hxan_c": -1.0, "h_c": 1.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "HXAND", "gene_reaction_rule": "ECS88_3145 and ECS88_3146 and ECS88_3147"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Hexanoate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HXAtex"]}, "metabolites": {"hxa_p": 1.0, "hxa_e": -1.0}, "id": "HXAtex", "gene_reaction_rule": "ECS88_2364 or ECS88_0276 or ECS88_0957 or ECS88_1492"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Acetyl-CoA:hexanoate-CoA transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HXCT"]}, "metabolites": {"ac_c": 1.0, "hxa_c": -1.0, "hxcoa_c": 1.0, "accoa_c": -1.0}, "id": "HXCT", "gene_reaction_rule": "ECS88_2370 and ECS88_2371"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Hypoxanthine phosphoribosyltransferase (Hypoxanthine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HXPRT"]}, "metabolites": {"ppi_c": 1.0, "imp_c": 1.0, "prpp_c": -1.0, "hxan_c": -1.0}, "id": "HXPRT", "gene_reaction_rule": "ECS88_0273 or ECS88_0134"}, {"subsystem": "Oxidative Phosphorylation", "name": "Hydrogenase (ubiquinone-8: 2 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HYD1pp"]}, "metabolites": {"q8h2_c": 1.0, "h2_c": -1.0, "q8_c": -1.0, "h_p": 2.0, "h_c": -2.0}, "id": "HYD1pp", "gene_reaction_rule": "(ECS88_0994 and ECS88_0995 and ECS88_0996) or (ECS88_3376 and ECS88_3377 and ECS88_3378 and ECS88_3379) or (ECS88_2984 and ECS88_2985 and ECS88_2986 and ECS88_2987 and ECS88_2988 and ECS88_2989)"}, {"subsystem": "Oxidative Phosphorylation", "name": "Hydrogenase (menaquinone8: 2 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HYD2pp"]}, "metabolites": {"h_p": 2.0, "mqn8_c": -1.0, "h2_c": -1.0, "h_c": -2.0, "mql8_c": 1.0}, "id": "HYD2pp", "gene_reaction_rule": "(ECS88_0994 and ECS88_0995 and ECS88_0996) or (ECS88_3376 and ECS88_3377 and ECS88_3378 and ECS88_3379)"}, {"subsystem": "Oxidative Phosphorylation", "name": "Hydrogenase (Demethylmenaquinone-8: 2 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HYD3pp"]}, "metabolites": {"h_p": 2.0, "h2_c": -1.0, "2dmmq8_c": -1.0, "2dmmql8_c": 1.0, "h_c": -2.0}, "id": "HYD3pp", "gene_reaction_rule": "(ECS88_0994 and ECS88_0995 and ECS88_0996) or (ECS88_3376 and ECS88_3377 and ECS88_3378 and ECS88_3379)"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Hypothetical enyme", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HYPOE"]}, "metabolites": {"pydam_c": 1.0, "pyam5p_c": -1.0, "pi_c": 1.0, "h2o_c": -1.0}, "id": "HYPOE", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Hypoxanthine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HYXNtex"]}, "metabolites": {"hxan_e": 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Biosynthesis", "name": "ISC [2Fe-2S] Transfer", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["I2FE2ST"]}, "metabolites": {"2fe2s_c": 1.0, "iscu_c": 1.0, "h_c": -4.0, "iscu_2fe2s_c": -1.0}, "id": "I2FE2ST", "gene_reaction_rule": "ECS88_2704 and ECS88_2705"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "ISC [4Fe-4S] Reduction", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["I4FE4SR"]}, "metabolites": {"fad_c": 1.0, "fadh2_c": -1.0, "iscu_4fe4s_c": 1.0, "h_c": -2.0, "iscu_2fe2s2_c": -1.0}, "id": "I4FE4SR", "gene_reaction_rule": "ECS88_2705"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "ISC [4Fe-4S] Transfer", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["I4FE4ST"]}, "metabolites": {"iscu_4fe4s_c": -1.0, "iscu_c": 1.0, "4fe4s_c": 1.0, "h_c": -4.0}, "id": "I4FE4ST", "gene_reaction_rule": "ECS88_2704 and ECS88_2705"}, {"subsystem": "Citric Acid Cycle", "name": "Isocitrate dehydrogenase (NADP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ICDHyr"]}, "metabolites": {"akg_c": 1.0, "icit_c": -1.0, "co2_c": 1.0, "nadph_c": 1.0, "nadp_c": -1.0}, "id": "ICDHyr", "gene_reaction_rule": "ECS88_1151"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Isochorismate synthase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ICHORS", "ICHORSi"]}, "metabolites": {"chor_c": -1.0, "ichor_c": 1.0}, "id": "ICHORS_copy1", "gene_reaction_rule": "ECS88_2416"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Isochorismate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ICHORS", "ICHORSi"]}, "metabolites": {"chor_c": -1.0, "ichor_c": 1.0}, "id": "ICHORS_copy2", "gene_reaction_rule": "ECS88_0632"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Isochorismatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ICHORT"]}, "metabolites": {"pyr_c": 1.0, "ichor_c": -1.0, "h2o_c": -1.0, "23ddhb_c": 1.0}, "id": "ICHORT", "gene_reaction_rule": "ECS88_0634"}, {"subsystem": "Anaplerotic Reactions", "name": "Isocitrate lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ICL"]}, "metabolites": {"succ_c": 1.0, "icit_c": -1.0, "glx_c": 1.0}, "id": "ICL", "gene_reaction_rule": "ECS88_4480"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "ISC Cysteine desulfuration", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ICYSDS"]}, "metabolites": {"cys__L_c": -1.0, "ala__L_c": 1.0, "iscssh_c": 1.0, "iscs_c": -1.0}, "id": "ICYSDS", "gene_reaction_rule": "ECS88_2706"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-idonate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IDONtex"]}, "metabolites": {"idon__L_p": 1.0, "idon__L_e": -1.0}, "id": "IDONtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Histidine Metabolism", "name": "Imidazole-glycerol-3-phosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IG3PS"]}, "metabolites": {"aicar_c": 1.0, "glu__L_c": 1.0, "eig3p_c": 1.0, "h_c": 1.0, "prlp_c": -1.0, "gln__L_c": -1.0}, "id": "IG3PS", "gene_reaction_rule": "ECS88_2122 and ECS88_2124"}, {"subsystem": "Histidine Metabolism", "name": "Imidazoleglycerol-phosphate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IGPDH"]}, "metabolites": {"h2o_c": 1.0, "imacp_c": 1.0, "eig3p_c": -1.0}, "id": "IGPDH", "gene_reaction_rule": "ECS88_2121"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Indole-3-glycerol-phosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IGPS"]}, "metabolites": {"h2o_c": 1.0, "co2_c": 1.0, "h_c": -1.0, "2cpr5p_c": -1.0, "3ig3p_c": 1.0}, "id": "IGPS", "gene_reaction_rule": "ECS88_1397"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Isoleucine transaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ILETA"]}, "metabolites": {"akg_c": -1.0, "3mop_c": 1.0, "glu__L_c": 1.0, "ile__L_c": -1.0}, "id": "ILETA", "gene_reaction_rule": "ECS88_4193"}, {"subsystem": "tRNA Charging", "name": "Isoleucyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ILETRS"]}, "metabolites": {"iletrna_c": 1.0, "trnaile_c": -1.0, "atp_c": -1.0, "ile__L_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0}, "id": "ILETRS", "gene_reaction_rule": "ECS88_0025"}, {"subsystem": "Transport, Inner Membrane", "name": "L-isoleucine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ILEabcpp"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "atp_c": -1.0, "ile__L_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "ile__L_p": -1.0}, "id": "ILEabcpp", "gene_reaction_rule": "ECS88_3851 and ECS88_3852 and ECS88_3854 and ECS88_3857 and ECS88_3853"}, {"subsystem": "Transport, Inner Membrane", "name": "L-isoleucine reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ILEt2rpp"]}, "metabolites": {"ile__L_c": 1.0, "ile__L_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "ILEt2rpp", "gene_reaction_rule": "ECS88_0396"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-isoleucine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ILEtex"]}, "metabolites": {"ile__L_p": 1.0, "ile__L_e": -1.0}, "id": "ILEtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "IMP cyclohydrolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IMPC"]}, "metabolites": {"h2o_c": -1.0, "fprica_c": 1.0, "imp_c": -1.0}, "id": "IMPC", "gene_reaction_rule": "ECS88_4467"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "IMP dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IMPD"]}, "metabolites": {"xmp_c": 1.0, "h2o_c": -1.0, "h_c": 1.0, "nad_c": -1.0, "nadh_c": 1.0, "imp_c": -1.0}, "id": "IMPD", "gene_reaction_rule": "ECS88_2680"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "IMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IMPtex"]}, "metabolites": {"imp_e": -1.0, "imp_p": 1.0}, "id": "IMPtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "Indole transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["INDOLEt2rpp"]}, "metabolites": {"h_p": -1.0, "h_c": 1.0, "indole_p": -1.0, "indole_c": 1.0}, "id": "INDOLEt2rpp", "gene_reaction_rule": "ECS88_3545"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Indole transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["INDOLEtex"]}, "metabolites": {"indole_e": -1.0, "indole_p": 1.0}, "id": "INDOLEtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Inosine hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["INSH"]}, "metabolites": {"h2o_c": -1.0, "hxan_c": 1.0, "rib__D_c": 1.0, "ins_c": -1.0}, "id": "INSH", "gene_reaction_rule": "ECS88_0029"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Insosine kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["INSK"]}, "metabolites": {"h_c": 1.0, "imp_c": 1.0, "adp_c": 1.0, "atp_c": -1.0, "ins_c": -1.0}, "id": "INSK", "gene_reaction_rule": "ECS88_0474"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Inositol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["INSTtex"]}, "metabolites": {"inost_e": -1.0, "inost_p": 1.0}, "id": "INSTtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "Inosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["INSt2pp", "INSt2rpp"]}, "metabolites": {"ins_p": -1.0, "h_c": 1.0, "h_p": -1.0, "ins_c": 1.0}, "id": "INSt2pp_copy1", "gene_reaction_rule": "ECS88_3247"}, {"subsystem": "Transport, Inner Membrane", "name": "Inosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["INSt2pp", "INSt2rpp"]}, "metabolites": {"ins_p": -1.0, "h_c": 1.0, "h_p": -1.0, "ins_c": 1.0}, "id": "INSt2pp_copy2", "gene_reaction_rule": "ECS88_2595"}, {"subsystem": "Transport, Outer Membrane", "name": "Inosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["INStex"]}, "metabolites": {"ins_e": -1.0, "ins_p": 1.0}, "id": "INStex", "gene_reaction_rule": "ECS88_0406"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Isopentenyl-diphosphate D-isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IPDDI"]}, "metabolites": {"dmpp_c": 1.0, "ipdp_c": -1.0}, "id": "IPDDI", "gene_reaction_rule": "ECS88_3169"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (ipdp)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IPDPS"]}, "metabolites": {"h2o_c": 1.0, "ipdp_c": 1.0, "h2mb4p_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "nadh_c": -1.0}, "id": "IPDPS", "gene_reaction_rule": "ECS88_0028"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "3-isopropylmalate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IPMD"]}, "metabolites": {"3c4mop_c": 1.0, "3c2hmp_c": -1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "IPMD", "gene_reaction_rule": "ECS88_0078"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "3-isopropylmalate dehydratase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IPPMIa"]}, "metabolites": {"3c2hmp_c": -1.0, "h2o_c": 1.0, "2ippm_c": 1.0}, "id": "IPPMIa", "gene_reaction_rule": "ECS88_0076 and ECS88_0077"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "2-isopropylmalate hydratase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IPPMIb"]}, "metabolites": {"2ippm_c": -1.0, "h2o_c": -1.0, "3c3hmp_c": 1.0}, "id": "IPPMIb", "gene_reaction_rule": "ECS88_0076 and ECS88_0077"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "2-isopropylmalate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IPPS"]}, "metabolites": {"h2o_c": -1.0, "3c3hmp_c": 1.0, "3mob_c": -1.0, "coa_c": 1.0, "h_c": 1.0, "accoa_c": -1.0}, "id": "IPPS", "gene_reaction_rule": "ECS88_0079"}, {"subsystem": "Transport, Inner Membrane", "name": "Isethionate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ISETACabcpp"]}, "metabolites": {"isetac_c": 1.0, "h2o_c": -1.0, "atp_c": -1.0, "isetac_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "ISETACabcpp", "gene_reaction_rule": "(ECS88_0362 and ECS88_0363 and ECS88_0364) or (ECS88_0964 and ECS88_0961 and ECS88_0962)"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Isethionate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ISETACtex"]}, "metabolites": {"isetac_p": 1.0, "isetac_e": -1.0}, "id": "ISETACtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "KDO(2)-lipid IV A transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["K2L4Aabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "kdo2lipid4_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "kdo2lipid4_c": -1.0, "pi_c": 1.0}, "id": "K2L4Aabcpp", "gene_reaction_rule": "ECS88_0942"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "KDO(2)-lipid IV A transport via ABC system (periplasm to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["K2L4Aabctex"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "kdo2lipid4_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "kdo2lipid4_e": 1.0}, "id": "K2L4Aabctex", "gene_reaction_rule": "ECS88_3583 and ECS88_3584 and ECS88_3582 and ECS88_4848 and ECS88_4849"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Ketol-acid reductoisomerase (2,3-dihydroxy-3-methylbutanoate)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["KARA1"]}, "metabolites": {"nadp_c": -1.0, "nadph_c": 1.0, "h_c": 1.0, "23dhmb_c": -1.0, "alac__S_c": 1.0}, "id": "KARA1", "gene_reaction_rule": "ECS88_4197"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Ketol-acid reductoisomerase (2-Acetolactate)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["KARA2"]}, "metabolites": {"23dhmp_c": 1.0, "2ahbut_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0}, "id": "KARA2", "gene_reaction_rule": "ECS88_4197"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Beta-ketoacyl-ACP synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KAS14"]}, "metabolites": {"acACP_c": -1.0, "ACP_c": 1.0, "malACP_c": -1.0, "h_c": -1.0, "actACP_c": 1.0, "co2_c": 1.0}, "id": "KAS14", "gene_reaction_rule": "ECS88_2471 or ECS88_1109"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Beta-ketoacyl-ACP synthase (2)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KAS15"]}, "metabolites": {"malACP_c": -1.0, "coa_c": 1.0, "h_c": -1.0, "accoa_c": -1.0, "actACP_c": 1.0, "co2_c": 1.0}, "id": "KAS15", "gene_reaction_rule": "ECS88_1105"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "3-deoxy-manno-octulosonate cytidylyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KDOCT2"]}, "metabolites": {"ctp_c": -1.0, "ckdo_c": 1.0, "ppi_c": 1.0, "kdo_c": -1.0}, "id": "KDOCT2", "gene_reaction_rule": "ECS88_0946"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "3-deoxy-manno-octulosonate-8-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KDOPP"]}, "metabolites": {"kdo_c": 1.0, "kdo8p_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0}, "id": "KDOPP", "gene_reaction_rule": "ECS88_3581"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "3-deoxy -D-manno-octulosonic -acid 8-phosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KDOPS"]}, "metabolites": {"ara5p_c": -1.0, "kdo8p_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0, "pep_c": -1.0}, "id": "KDOPS", "gene_reaction_rule": "ECS88_1283"}, {"subsystem": "Alternate Carbon Metabolism", "name": "3-keto-L-gulonate 6-phosphate decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KG6PDC"]}, "metabolites": {"xu5p__L_c": 1.0, "3dhgulnp_c": -1.0, "co2_c": 1.0, "h_c": -1.0}, "id": "KG6PDC", "gene_reaction_rule": "ECS88_4782 or ECS88_4001"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Potassium ABC transporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["Kabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "k_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "k_c": 1.0, "pi_c": 1.0}, "id": "Kabcpp", "gene_reaction_rule": "(ECS88_0732 and ECS88_0731 and ECS88_0730) or (ECS88_0732 and ECS88_0731 and ECS88_0730 and ECS88_0733)"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Potassium transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["Kt2pp"]}, "metabolites": {"k_p": -1.0, "k_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "Kt2pp", "gene_reaction_rule": "(ECS88_1437 and ECS88_3677 and ECS88_4297) or ECS88_1319 or ECS88_4169"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Potassium transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["Kt3pp"]}, "metabolites": {"k_p": 1.0, "k_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "Kt3pp", "gene_reaction_rule": "ECS88_1285 or ECS88_0859 or ECS88_3739 or ECS88_0050"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Potassium transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["Ktex"]}, "metabolites": {"k_p": 1.0, "k_e": -1.0}, "id": "Ktex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Oxidative Phosphorylation", "name": "L-Lactate dehydrogenase (ubiquinone)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["L_DASH_LACD2"]}, "metabolites": {"q8h2_c": 1.0, "pyr_c": 1.0, "lac__L_c": -1.0, "q8_c": -1.0}, "id": "L_LACD2", "gene_reaction_rule": "ECS88_4022 or (ECS88_0307 and ECS88_0308 and ECS88_0309)"}, {"subsystem": "Oxidative Phosphorylation", "name": "L-Lactate dehydrogenase (menaquinone)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["L_DASH_LACD3"]}, "metabolites": {"mqn8_c": -1.0, "pyr_c": 1.0, "lac__L_c": -1.0, "mql8_c": 1.0}, "id": "L_LACD3", "gene_reaction_rule": "ECS88_4022 or (ECS88_0307 and ECS88_0308 and ECS88_0309)"}, {"subsystem": "Transport, Inner Membrane", "name": "L-lactate reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["L_DASH_LACt2rpp"]}, "metabolites": {"lac__L_c": 1.0, "h_c": 1.0, "h_p": -1.0, "lac__L_p": -1.0}, "id": "L_LACt2rpp", "gene_reaction_rule": "ECS88_3349"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-lactate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["L_DASH_LACtex"]}, "metabolites": {"lac__L_e": -1.0, "lac__L_p": 1.0}, "id": "L_LACtex", "gene_reaction_rule": "ECS88_0957 or ECS88_1492 or ECS88_2364 or ECS88_0276"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "4-amino-4-deoxy-L-arabinotransferase (LPS lipid A modification, periplasmic face of membrane))", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LA4NTpp"]}, "metabolites": {"acolipa_p": 1.0, "colipa_p": -1.0, "uLa4n_p": -1.0, "udcpp_p": 1.0}, "id": "LA4NTpp", "gene_reaction_rule": "ECS88_2407"}, {"subsystem": "Alternate Carbon Metabolism", "name": "B-galactosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LACZ"]}, "metabolites": {"lcts_c": -1.0, "glc__D_c": 1.0, "h2o_c": -1.0, "gal_c": 1.0}, "id": "LACZ", "gene_reaction_rule": "ECS88_0351"}, {"subsystem": "Alternate Carbon Metabolism", "name": "B-galactosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LACZpp"]}, "metabolites": {"gal_p": 1.0, "h2o_p": -1.0, "lcts_p": -1.0, "glc__D_p": 1.0}, "id": "LACZpp", "gene_reaction_rule": "ECS88_2276"}, {"subsystem": "Murein Recycling", "name": "L-alanyl-gamma-D-glutamyl-meso-diaminopimelate hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LADGMDH"]}, "metabolites": {"LalaDglu_c": 1.0, "26dap__M_c": 1.0, "h2o_c": -1.0, "LalaDgluMdap_c": -1.0}, "id": "LADGMDH", "gene_reaction_rule": "ECS88_1468"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-alanyl-D-glutamate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LALADGLUtex"]}, "metabolites": {"LalaDglu_p": 1.0, "LalaDglu_e": -1.0}, "id": "LALADGLUtex", "gene_reaction_rule": "ECS88_2364 or ECS88_1492 or ECS88_0276 or ECS88_0957"}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanyl-D-glutamate transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LALADGLUtpp"]}, "metabolites": {"LalaDglu_p": -1.0, "LalaDglu_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "LALADGLUtpp", "gene_reaction_rule": "ECS88_1682 or ECS88_3901 or ECS88_4634 or ECS88_0737"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-alanyl-L-glutamate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LALALGLUtex"]}, "metabolites": {"LalaLglu_p": 1.0, "LalaLglu_e": -1.0}, "id": "LALALGLUtex", "gene_reaction_rule": "ECS88_2364 or ECS88_1492 or ECS88_0276 or ECS88_0957"}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanyl-L-glutamate transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LALALGLUtpp"]}, "metabolites": {"LalaLglu_p": -1.0, "LalaLglu_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "LALALGLUtpp", "gene_reaction_rule": "ECS88_1682 or ECS88_3901 or ECS88_4634 or ECS88_0737"}, {"subsystem": "Methylglyoxal Metabolism", "name": "D-Lactaldehyde:NAD+ 1-oxidoreductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LALDO2x"]}, "metabolites": {"nad_c": 1.0, "nadh_c": -1.0, "h_c": -1.0, "mthgxl_c": -1.0, "lald__D_c": 1.0}, "id": "LALDO2x", "gene_reaction_rule": "ECS88_4401"}, {"subsystem": "Methylglyoxal Metabolism", "name": "L-Lactaldehyde:NADP+ 1-oxidoreductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LALDO3"]}, "metabolites": {"nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "lald__L_c": 1.0, "mthgxl_c": -1.0}, "id": "LALDO3", "gene_reaction_rule": ""}, {"subsystem": "Murein Recycling", "name": "L-alanyl-gamma-L-glutamate peptidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LALGP"]}, "metabolites": {"glu__L_c": 1.0, "ala__L_c": 1.0, "LalaLglu_c": -1.0, "h2o_c": -1.0}, "id": "LALGP", "gene_reaction_rule": "ECS88_0272"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Lactaldehyde dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LCADi"]}, "metabolites": {"h2o_c": -1.0, "lald__L_c": -1.0, "lac__L_c": 1.0, "h_c": 2.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "LCADi", "gene_reaction_rule": "ECS88_1511"}, {"subsystem": "Methylglyoxal Metabolism", "name": "Lacaldehyde reductase (R-propane-1,2-diol forming)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LCARR"]}, "metabolites": {"h_c": -1.0, "nadh_c": -1.0, "lald__D_c": -1.0, "nad_c": 1.0, "12ppd__R_c": 1.0}, "id": "LCARR", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Lacaldehyde reductase (S-propane-1,2-diol forming)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LCARS"]}, "metabolites": {"nad_c": 1.0, "nadh_c": -1.0, "12ppd__S_c": 1.0, "h_c": -1.0, "lald__L_c": -1.0}, "id": "LCARS", "gene_reaction_rule": "ECS88_3068"}, {"subsystem": "Transport, Inner Membrane", "name": "Lactose transport via proton aniport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LCTSt3ipp"]}, "metabolites": {"lcts_c": -1.0, "lcts_p": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "LCTSt3ipp", "gene_reaction_rule": "ECS88_2318 or ECS88_1604"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Lactose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LCTStex"]}, "metabolites": {"lcts_p": 1.0, "lcts_e": -1.0}, "id": "LCTStex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "Lactose transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LCTStpp"]}, "metabolites": {"lcts_c": 1.0, "lcts_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "LCTStpp", "gene_reaction_rule": "ECS88_0350"}, {"subsystem": "Pyruvate Metabolism", "name": "D-lactate dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LDH_D"]}, "metabolites": {"pyr_c": 1.0, "nadh_c": 1.0, "lac__D_c": -1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "LDH_D", "gene_reaction_rule": "ECS88_2277 or ECS88_1496"}, {"subsystem": "Oxidative Phosphorylation", "name": "D-lactate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LDH_D2"]}, "metabolites": {"q8h2_c": 1.0, "pyr_c": 1.0, "lac__D_c": -1.0, "q8_c": -1.0}, "id": "LDH_D2", "gene_reaction_rule": "ECS88_2277"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Leucine transaminase (irreversible)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LEUTAi"]}, "metabolites": {"akg_c": 1.0, "leu__L_c": 1.0, "4mop_c": -1.0, "glu__L_c": -1.0}, "id": "LEUTAi", "gene_reaction_rule": "ECS88_4193 or ECS88_4533"}, {"subsystem": "tRNA Charging", "name": "Leucyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LEUTRS"]}, "metabolites": {"leutrna_c": 1.0, "leu__L_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "trnaleu_c": -1.0}, "id": "LEUTRS", "gene_reaction_rule": "ECS88_0684"}, {"subsystem": "Transport, Inner Membrane", "name": "L-leucine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LEUabcpp"]}, "metabolites": {"leu__L_c": 1.0, "atp_c": -1.0, "h2o_c": -1.0, "leu__L_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "LEUabcpp", "gene_reaction_rule": "(ECS88_3851 and ECS88_3852 and ECS88_3854 and ECS88_3857 and ECS88_3853) or (ECS88_3851 and ECS88_3852 and ECS88_3854 and ECS88_3855 and ECS88_3853)"}, {"subsystem": "Transport, Inner Membrane", "name": "L-leucine reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LEUt2rpp"]}, "metabolites": {"leu__L_p": -1.0, "leu__L_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "LEUt2rpp", "gene_reaction_rule": "ECS88_0396"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-leucine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LEUtex"]}, "metabolites": {"leu__L_p": 1.0, "leu__L_e": -1.0}, "id": "LEUtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Methylglyoxal Metabolism", "name": "Lactoylglutathione lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LGTHL"]}, "metabolites": {"gthrd_c": -1.0, "lgt__S_c": 1.0, "mthgxl_c": -1.0}, "id": "LGTHL", "gene_reaction_rule": "ECS88_1700"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Lipid (cold) A transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPACabcpp"]}, "metabolites": {"h2o_c": -1.0, "lipa_cold_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "lipa_cold_p": 1.0, "pi_c": 1.0}, "id": "LIPACabcpp", "gene_reaction_rule": "ECS88_0942"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Core oligosaccharide lipid A:hexadecanoate transferase (n-C16:0) (extracellular membrane)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPAHT2ex"]}, "metabolites": {"hdca_e": -1.0, "h_e": -1.0, "h2o_e": 1.0, "hacolipa_e": 1.0, "colipa_e": -1.0}, "id": "LIPAHT2ex", "gene_reaction_rule": "ECS88_0664"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Lipid A:hexadecanoate transferase (n-C16:0) (extracellular membrane)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPAHTex"]}, "metabolites": {"lipa_e": -1.0, "hdca_e": -1.0, "h_e": -1.0, "h2o_e": 1.0, "halipa_e": 1.0}, "id": "LIPAHTex", "gene_reaction_rule": "ECS88_0664"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Lipoyl-adenylate protein ligase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPAMPL"]}, "metabolites": {"amp_c": 1.0, "lipopb_c": 1.0, "lipoamp_c": -1.0}, "id": "LIPAMPL", "gene_reaction_rule": "ECS88_5067"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Lipoate-ATP adenylate transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPATPT"]}, "metabolites": {"ppi_c": 1.0, "lipoate_c": -1.0, "atp_c": -1.0, "lipoamp_c": 1.0}, "id": "LIPATPT", "gene_reaction_rule": "ECS88_5067"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Lipid A transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPAabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "lipa_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "lipa_c": -1.0}, "id": "LIPAabcpp", "gene_reaction_rule": "ECS88_0942"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Lipid A transport via ABC system (periplasm to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPAabctex"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "lipa_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "lipa_e": 1.0, "pi_c": 1.0}, "id": "LIPAabctex", "gene_reaction_rule": "ECS88_3583 and ECS88_3584 and ECS88_3582 and ECS88_4848 and ECS88_4849"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Lipoyl(octanoyl) transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPOCT"]}, "metabolites": {"ACP_c": 1.0, "h_c": -1.0, "ocACP_c": -1.0, "octapb_c": 1.0}, "id": "LIPOCT", "gene_reaction_rule": "ECS88_0671"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Lipoate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPOS"]}, "metabolites": {"nad_c": -1.0, "fe2_c": 2.0, "dad_5_c": 2.0, "octapb_c": -1.0, "2fe2s_c": 1.0, "h_c": -1.0, "met__L_c": 2.0, "amet_c": -2.0, "nadh_c": 1.0, "lipopb_c": 1.0, "4fe4s_c": -1.0}, "id": "LIPOS", "gene_reaction_rule": "ECS88_0669"}, {"subsystem": "Transport, Inner Membrane", "name": "Lipoate transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPOt2pp"]}, "metabolites": {"h_p": -1.0, "lipoate_c": 1.0, "lipoate_p": -1.0, "h_c": 1.0}, "id": "LIPOt2pp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Lipoate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LIPOtex"]}, "metabolites": {"lipoate_e": -1.0, "lipoate_p": 1.0}, "id": "LIPOtex", "gene_reaction_rule": "ECS88_1492 or ECS88_2364 or ECS88_0957 or ECS88_0276"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Lipid A disaccaride synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": 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"gene_reaction_rule": "ECS88_4253"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E141"]}, "metabolites": {"2agpe141_c": -1.0, "h2o_c": -1.0, "g3pe_c": 1.0, "h_c": 1.0, "ttdcea_c": 1.0}, "id": "LPLIPAL2E141", "gene_reaction_rule": "ECS88_4253"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E160"]}, "metabolites": {"h2o_c": -1.0, "hdca_c": 1.0, "h_c": 1.0, "2agpe160_c": -1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2E160", "gene_reaction_rule": "ECS88_4253"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E161"]}, 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(2-acylglycerophosphoglycerol, n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G120"]}, "metabolites": {"ddca_c": 1.0, "g3pg_c": 1.0, "h2o_c": -1.0, "2agpg120_c": -1.0, "h_c": 1.0}, "id": "LPLIPAL2G120", "gene_reaction_rule": "ECS88_4253"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G140"]}, "metabolites": {"g3pg_c": 1.0, "h2o_c": -1.0, "ttdca_c": 1.0, "2agpg140_c": -1.0, "h_c": 1.0}, "id": "LPLIPAL2G140", "gene_reaction_rule": "ECS88_4253"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G141"]}, "metabolites": {"g3pg_c": 1.0, "h2o_c": -1.0, "2agpg141_c": -1.0, "h_c": 1.0, "ttdcea_c": 1.0}, "id": "LPLIPAL2G141", "gene_reaction_rule": "ECS88_4253"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G160"]}, "metabolites": {"2agpg160_c": -1.0, "g3pg_c": 1.0, "h2o_c": -1.0, "hdca_c": 1.0, "h_c": 1.0}, "id": "LPLIPAL2G160", "gene_reaction_rule": "ECS88_4253"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G161"]}, "metabolites": {"hdcea_c": 1.0, "2agpg161_c": -1.0, "h2o_c": -1.0, "h_c": 1.0, "g3pg_c": 1.0}, "id": "LPLIPAL2G161", "gene_reaction_rule": "ECS88_4253"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G180"]}, "metabolites": {"g3pg_c": 1.0, "h2o_c": -1.0, "h_c": 1.0, "2agpg180_c": -1.0, "ocdca_c": 1.0}, "id": "LPLIPAL2G180", "gene_reaction_rule": "ECS88_4253"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G181"]}, "metabolites": {"ocdcea_c": 1.0, "h2o_c": -1.0, "2agpg181_c": -1.0, "h_c": 1.0, "g3pg_c": 1.0}, "id": "LPLIPAL2G181", "gene_reaction_rule": "ECS88_4253"}, {"subsystem": "Glycine and Serine Metabolism", "name": "L-serine dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LSERDHr"]}, "metabolites": {"2amsa_c": 1.0, "ser__L_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "h_c": 1.0}, "id": "LSERDHr", "gene_reaction_rule": "ECS88_1619"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Lysine decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSDC"]}, "metabolites": {"15dap_c": 1.0, "co2_c": 1.0, "lys__L_c": -1.0, "h_c": -1.0}, "id": "LYSDC", "gene_reaction_rule": "ECS88_0197"}, {"subsystem": "tRNA Charging", "name": "Lysyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSTRS"]}, "metabolites": {"trnalys_c": -1.0, "lys__L_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "lystrna_c": 1.0}, "id": "LYSTRS", "gene_reaction_rule": "ECS88_3170"}, {"subsystem": "Transport, Inner Membrane", "name": "L-lysine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSabcpp"]}, "metabolites": {"h2o_c": -1.0, "lys__L_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "lys__L_p": -1.0, "pi_c": 1.0}, "id": "LYSabcpp", "gene_reaction_rule": "ECS88_2457 and ECS88_2454 and ECS88_2453 and ECS88_2455"}, {"subsystem": "Transport, Inner Membrane", "name": "L-lysine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSt2pp"]}, "metabolites": {"lys__L_c": 1.0, "h_c": 1.0, "h_p": -1.0, "lys__L_p": -1.0}, "id": "LYSt2pp", "gene_reaction_rule": "ECS88_2304"}, {"subsystem": "Transport, Inner Membrane", "name": "L-lysine transport out via proton antiport (cytoplasm to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSt3pp"]}, "metabolites": {"lys__L_c": -1.0, "h_c": 1.0, "h_p": -1.0, "lys__L_p": 1.0}, "id": "LYSt3pp", "gene_reaction_rule": "ECS88_3199"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-lysine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LYStex"]}, "metabolites": {"lys__L_e": -1.0, "lys__L_p": 1.0}, "id": "LYStex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Lyxose isomerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYXI"]}, "metabolites": {"xylu__L_c": 1.0, "lyx__L_c": -1.0}, "id": "LYXI", "gene_reaction_rule": "ECS88_4350"}, {"subsystem": "Transport, Inner Membrane", "name": "L-Lyxose transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYXt2pp"]}, "metabolites": {"h_c": 1.0, "lyx__L_p": -1.0, "h_p": -1.0, "lyx__L_c": 1.0}, "id": "LYXt2pp", "gene_reaction_rule": "ECS88_4357"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-Lyxose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LYXtex"]}, "metabolites": {"lyx__L_e": -1.0, "lyx__L_p": 1.0}, "id": "LYXtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Mannitol-1-phosphate 5-dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["M1PD"]}, "metabolites": {"h_c": 1.0, "nadh_c": 1.0, "mnl1p_c": -1.0, "nad_c": -1.0, "f6p_c": 1.0}, "id": "M1PD", "gene_reaction_rule": "ECS88_4013"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Malonyl-ACP decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MACPD"]}, "metabolites": {"acACP_c": 1.0, "co2_c": 1.0, "malACP_c": -1.0, "h_c": -1.0}, "id": "MACPD", "gene_reaction_rule": "ECS88_2471"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Malonyl-CoA methyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALCOAMT"]}, "metabolites": {"amet_c": -1.0, "malcoame_c": 1.0, "malcoa_c": -1.0, "ahcys_c": 1.0}, "id": "MALCOAMT", "gene_reaction_rule": "ECS88_0794"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Malate decarboxylating oxidoreductase (decarboxylating)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALDDH"]}, "metabolites": {"nad_c": -1.0, "pyr_c": 1.0, "co2_c": 1.0, "mal__D_c": -1.0, "nadh_c": 1.0}, "id": "MALDDH", "gene_reaction_rule": "dmlA"}, {"subsystem": "Transport, Inner Membrane", "name": "D-Malate transport via proton symport (2 H) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALDt2_2pp"]}, "metabolites": {"mal__D_p": -1.0, "mal__D_c": 1.0, "h_c": 2.0, "h_p": -2.0}, "id": "MALDt2_2pp", "gene_reaction_rule": "ECS88_3942"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-Malate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MALDtex"]}, "metabolites": {"mal__D_p": 1.0, "mal__D_e": -1.0}, "id": "MALDtex", "gene_reaction_rule": "ECS88_2364 or ECS88_1492 or ECS88_0276 or ECS88_0957"}, {"subsystem": "Anaplerotic Reactions", "name": "Malate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALS"]}, "metabolites": {"h2o_c": -1.0, "mal__L_c": 1.0, "glx_c": -1.0, "h_c": 1.0, "accoa_c": -1.0, "coa_c": 1.0}, "id": "MALS", "gene_reaction_rule": "ECS88_4479 or ECS88_3350"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltose O-acetyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MALTATr"]}, "metabolites": {"coa_c": 1.0, "malt_c": -1.0, "acmalt_c": 1.0, "accoa_c": -1.0}, "id": "MALTATr", "gene_reaction_rule": "ECS88_0456"}, {"subsystem": "Transport, Inner Membrane", "name": "Maltohexaose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTHXabcpp"]}, "metabolites": {"h2o_c": -1.0, "malthx_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "malthx_p": -1.0, "pi_c": 1.0}, "id": "MALTHXabcpp", "gene_reaction_rule": "ECS88_4508 and ECS88_4507 and ECS88_4506 and ECS88_4509"}, {"subsystem": "Transport, Outer Membrane", "name": "Maltohexaose transport via diffusion (extracellular to periplasm) irreversible", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTHXtexi"]}, "metabolites": {"malthx_e": -1.0, "malthx_p": 1.0}, "id": "MALTHXtexi", "gene_reaction_rule": "ECS88_4510"}, {"subsystem": "Transport, Inner Membrane", "name": "Maltopentaose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTPTabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "maltpt_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "maltpt_c": 1.0, "pi_c": 1.0}, "id": "MALTPTabcpp", "gene_reaction_rule": "ECS88_4508 and ECS88_4507 and ECS88_4506 and ECS88_4509"}, {"subsystem": "Transport, Outer Membrane", "name": "MaltopentaoseMaltotriose transport via diffusion (extracellular to periplasm) irreversible", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTPTtexi"]}, "metabolites": {"maltpt_p": 1.0, "maltpt_e": -1.0}, "id": "MALTPTtexi", "gene_reaction_rule": "ECS88_4510"}, {"subsystem": "Transport, Inner Membrane", "name": "Maltotriose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTTRabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "malttr_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "malttr_c": 1.0}, "id": "MALTTRabcpp", "gene_reaction_rule": "ECS88_4508 and ECS88_4507 and ECS88_4506 and ECS88_4509"}, {"subsystem": "Transport, Outer Membrane", "name": "Maltotriose transport via diffusion (extracellular to periplasm) irreversible", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTTRtexi"]}, "metabolites": {"malttr_e": -1.0, "malttr_p": 1.0}, "id": "MALTTRtexi", "gene_reaction_rule": "ECS88_4510"}, {"subsystem": "Transport, Inner Membrane", "name": "Maltotetraose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTTTRabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "maltttr_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "maltttr_p": -1.0}, "id": "MALTTTRabcpp", "gene_reaction_rule": "ECS88_4508 and ECS88_4507 and ECS88_4506 and ECS88_4509"}, {"subsystem": "Transport, Outer Membrane", "name": "MaltotetraoseMaltotriose transport via diffusion (extracellular to periplasm) irreversible", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTTTRtexi"]}, "metabolites": {"maltttr_e": -1.0, "maltttr_p": 1.0}, "id": "MALTTTRtexi", "gene_reaction_rule": "ECS88_4510"}, {"subsystem": "Transport, Inner Membrane", "name": "Maltose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "malt_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "malt_c": 1.0, "pi_c": 1.0}, "id": "MALTabcpp", "gene_reaction_rule": "ECS88_4508 and ECS88_4507 and ECS88_4506 and ECS88_4509"}, {"subsystem": "Transport, Inner Membrane", "name": "Maltose transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTptspp"]}, "metabolites": {"pep_c": -1.0, "malt_p": -1.0, "pyr_c": 1.0, "malt6p_c": 1.0}, "id": "MALTptspp", "gene_reaction_rule": "ECS88_2607 and ECS88_1668 and ECS88_2605 and ECS88_2606"}, {"subsystem": "Transport, Outer Membrane", "name": "MaltoseMaltotriose transport via diffusion (extracellular to periplasm) irreversible", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTtexi"]}, "metabolites": {"malt_p": 1.0, "malt_e": -1.0}, "id": "MALTtexi", "gene_reaction_rule": "ECS88_4510"}, {"subsystem": "Transport, Inner Membrane", "name": "Malate transport via proton symport (2 H) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALt2_2pp"]}, "metabolites": {"mal__L_p": -1.0, "mal__L_c": 1.0, "h_c": 2.0, "h_p": -2.0}, "id": "MALt2_2pp", "gene_reaction_rule": "ECS88_3942"}, {"subsystem": "Transport, Inner Membrane", "name": "Malate transport via proton symport (3 H) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALt2_3pp"]}, "metabolites": {"mal__L_p": -1.0, "mal__L_c": 1.0, "h_c": 3.0, "h_p": -3.0}, "id": "MALt2_3pp", "gene_reaction_rule": "ECS88_4624 or ECS88_4724"}, {"subsystem": "Transport, Inner Membrane", "name": "L-malate transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALt3pp"]}, "metabolites": {"mal__L_p": 1.0, "mal__L_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "MALt3pp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Malate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MALtex"]}, "metabolites": {"mal__L_p": 1.0, "mal__L_e": -1.0}, "id": "MALtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or 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{"subsystem": "Transport, Outer Membrane Porin", "name": "Mannose 6-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MAN6Ptex"]}, "metabolites": {"man6p_p": 1.0, "man6p_e": -1.0}, "id": "MAN6Ptex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Mannonate oxidoreductase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MANAO"]}, "metabolites": {"fruur_c": 1.0, "nadh_c": 1.0, "mana_c": -1.0, "nad_c": -1.0, "h_c": 1.0}, "id": "MANAO", "gene_reaction_rule": "ECS88_4941"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "2-O-alpha-mannosyl-D-glycerate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MANGLYCtex"]}, "metabolites": {"manglyc_e": -1.0, "manglyc_p": 1.0}, "id": "MANGLYCtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "D-mannose transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MANptspp"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "man6p_c": 1.0, "man_p": -1.0}, "id": "MANptspp", "gene_reaction_rule": "ECS88_1869 and ECS88_1870 and ECS88_1871 and ECS88_2605 and ECS88_2606"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-mannose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MANtex"]}, "metabolites": {"man_e": -1.0, "man_p": 1.0}, "id": "MANtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-methylcitrate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MCITD"]}, "metabolites": {"2mcit_c": -1.0, "h2o_c": 1.0, "2mcacn_c": 1.0}, "id": "MCITD", "gene_reaction_rule": "ECS88_0345"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Methylisocitrate lyase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MCITL2"]}, "metabolites": {"pyr_c": 1.0, "succ_c": 1.0, "micit_c": -1.0}, "id": "MCITL2", "gene_reaction_rule": "ECS88_0343"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-methylcitrate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MCITS"]}, "metabolites": {"h2o_c": -1.0, "ppcoa_c": -1.0, "2mcit_c": 1.0, "coa_c": 1.0, "h_c": 1.0, "oaa_c": -1.0}, "id": "MCITS", "gene_reaction_rule": "ECS88_0344"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Malonyl-CoA-ACP transacylase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MCOATA"]}, "metabolites": {"coa_c": 1.0, "ACP_c": -1.0, "malACP_c": 1.0, "malcoa_c": -1.0}, "id": "MCOATA", "gene_reaction_rule": "ECS88_1108 and ECS88_1106"}, {"subsystem": "Cysteine Metabolism", "name": "3-mercaptopyruvate sulfurtransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MCPST"]}, "metabolites": {"cyan_c": -1.0, "pyr_c": 1.0, "h_c": 1.0, "mercppyr_c": -1.0, "tcynt_c": 1.0}, "id": "MCPST", "gene_reaction_rule": "ECS88_2697"}, {"subsystem": "Murein Biosynthesis", "name": "Murein crosslinking transpeptidase 1A:(A2pm->D-ala) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MCTP1App"]}, "metabolites": {"murein5p5p_p": -1.0, "murein5px4p_p": 1.0, "ala__D_p": 1.0}, "id": "MCTP1App", "gene_reaction_rule": "ECS88_0087 or ECS88_0677 or ECS88_0159 or ECS88_3782"}, {"subsystem": "Murein Biosynthesis", "name": "Murein crosslinking transpeptidase 1B:(A2pm->A2pm) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MCTP1Bpp"]}, "metabolites": {"murein5p5p_p": -1.0, "murein5px3p_p": 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0.0, "notes": {"original_bigg_ids": ["MDDCP2pp"]}, "metabolites": {"h2o_p": -1.0, "murein4px4px4p_p": 1.0, "murein5px4px4p_p": -1.0, "ala__D_p": 1.0}, "id": "MDDCP2pp", "gene_reaction_rule": "ECS88_0673 or ECS88_3564 or ECS88_0856 or ECS88_2109"}, {"subsystem": "Murein Biosynthesis", "name": "Murein D,D-carboxypeptidase (murein5p5p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MDDCP3pp"]}, "metabolites": {"h2o_p": -1.0, "murein5p5p_p": -1.0, "murein5p4p_p": 1.0, "ala__D_p": 1.0}, "id": "MDDCP3pp", "gene_reaction_rule": "ECS88_0673 or ECS88_3564 or ECS88_0856 or ECS88_2109"}, {"subsystem": "Murein Biosynthesis", "name": "Murein D,D-carboxypeptidase (murein5p4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MDDCP4pp"]}, "metabolites": {"murein4p4p_p": 1.0, "h2o_p": -1.0, "murein5p4p_p": -1.0, "ala__D_p": 1.0}, "id": "MDDCP4pp", "gene_reaction_rule": "ECS88_0673 or ECS88_3564 or ECS88_0856 or ECS88_2109"}, {"subsystem": "Murein Biosynthesis", "name": "Murein D,D-carboxypeptidase (murein5p3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MDDCP5pp"]}, "metabolites": {"h2o_p": -1.0, "murein5p3p_p": -1.0, "murein4p3p_p": 1.0, "ala__D_p": 1.0}, "id": "MDDCP5pp", "gene_reaction_rule": "ECS88_0673 or ECS88_3564 or ECS88_0856 or ECS88_2109"}, {"subsystem": "Murein Recycling", "name": "Murein D,D-endopeptidase (murein4px4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MDDEP1pp"]}, "metabolites": {"murein4px4p_p": -1.0, "h2o_p": -1.0, "murein4p4p_p": 1.0}, "id": "MDDEP1pp", "gene_reaction_rule": "ECS88_3564 or ECS88_2476 or ECS88_2278"}, {"subsystem": "Murein Recycling", "name": "Murein D,D-endopeptidase (murein3px4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MDDEP2pp"]}, "metabolites": {"h2o_p": -1.0, "murein3px4p_p": -1.0, "murein4p3p_p": 1.0}, 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"upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MG2tpp"]}, "metabolites": {"mg2_c": 1.0, "mg2_p": -1.0}, "id": "MG2tpp", "gene_reaction_rule": "ECS88_4242"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Magnesium (Mg+2) ABC transporter (ubtake, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MG2uabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "mg2_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "mg2_c": 1.0}, "id": "MG2uabcpp", "gene_reaction_rule": "ECS88_4832"}, {"subsystem": "Methylglyoxal Metabolism", "name": "Methylglyoxal synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MGSA"]}, "metabolites": {"dhap_c": -1.0, "pi_c": 1.0, "mthgxl_c": 1.0}, "id": "MGSA", "gene_reaction_rule": "ECS88_0985"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Myo-inositol 1-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MI1PP"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "inost_c": 1.0, "mi1p__D_c": -1.0}, "id": "MI1PP", "gene_reaction_rule": "ECS88_2709"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-methylisocitrate dehydratase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MICITDr"]}, "metabolites": {"2mcacn_c": -1.0, "h2o_c": -1.0, "micit_c": 1.0}, "id": "MICITDr", "gene_reaction_rule": "ECS88_0127"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Minocycline transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MINCYCtex"]}, "metabolites": {"mincyc_e": -1.0, "mincyc_p": 1.0}, "id": "MINCYCtex", "gene_reaction_rule": "ECS88_1492 or ECS88_2364 or ECS88_0957 or ECS88_0276"}, {"subsystem": "Transport, Outer Membrane", "name": "Minocycline transport via TolC system", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MINCYCtpp"]}, "metabolites": {"h_p": -1.0, "mincyc_e": 1.0, "h_c": 1.0, "mincyc_p": -1.0}, "id": "MINCYCtpp", "gene_reaction_rule": "ECS88_0460 and ECS88_2649 and ECS88_3429"}, {"subsystem": "Transport, Outer Membrane", "name": "Myo-inositol phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MINOHPtexi"]}, "metabolites": {"minohp_p": 1.0, "minohp_e": -1.0}, "id": "MINOHPtexi", "gene_reaction_rule": ""}, {"subsystem": "Murein Biosynthesis", "name": "Murein L,D-carboxypeptidase (murein5px4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDCP1App"]}, "metabolites": {"murein5px4p_p": -1.0, "murein3px4p_p": 1.0, "alaala_p": 1.0, "h2o_p": -1.0}, "id": "MLDCP1App", "gene_reaction_rule": ""}, {"subsystem": "Murein Biosynthesis", "name": "Murein L,D-carboxypeptidase (murein4p4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDCP1Bpp"]}, "metabolites": {"h2o_p": -1.0, "murein4p3p_p": 1.0, "murein4p4p_p": -1.0, "ala__D_p": 1.0}, "id": "MLDCP1Bpp", "gene_reaction_rule": ""}, {"subsystem": "Murein Biosynthesis", "name": "Murein L,D-carboxypeptidase (murein5p5p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDCP2App"]}, "metabolites": {"h2o_p": -1.0, "murein5p5p_p": -1.0, "alaala_p": 1.0, "murein5p3p_p": 1.0}, "id": "MLDCP2App", "gene_reaction_rule": ""}, {"subsystem": "Murein Biosynthesis", "name": "Murein L,D-carboxypeptidase (murein4p3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDCP2Bpp"]}, "metabolites": {"murein3p3p_p": 1.0, "ala__D_p": 1.0, "murein4p3p_p": -1.0, "h2o_p": -1.0}, "id": "MLDCP2Bpp", "gene_reaction_rule": ""}, {"subsystem": "Murein Biosynthesis", "name": "Murein L,D-carboxypeptidase (murein5px3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDCP3App"]}, "metabolites": {"h2o_p": -1.0, "murein3px3p_p": 1.0, "murein5px3p_p": -1.0, "alaala_p": 1.0}, "id": "MLDCP3App", "gene_reaction_rule": ""}, {"subsystem": "Murein Recycling", "name": "Murein L,D-endopeptidase (murein3px3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDEP1pp"]}, "metabolites": {"h2o_p": -1.0, "murein3px3p_p": -1.0, "murein3p3p_p": 1.0}, "id": "MLDEP1pp", "gene_reaction_rule": ""}, {"subsystem": "Murein Recycling", "name": "Murein L,D-endopeptidase (murein5px3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDEP2pp"]}, "metabolites": {"h2o_p": -1.0, "murein5px3p_p": -1.0, "murein5p3p_p": 1.0}, "id": "MLDEP2pp", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltotriose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG1"]}, "metabolites": {"glc__D_c": 1.0, "h2o_c": -1.0, "malt_c": 1.0, "malttr_c": -1.0}, "id": "MLTG1", "gene_reaction_rule": "ECS88_0398"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltotetraose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG2"]}, "metabolites": {"glc__D_c": 1.0, "h2o_c": -1.0, "malttr_c": 1.0, "maltttr_c": -1.0}, "id": "MLTG2", "gene_reaction_rule": "ECS88_0398"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltopentaose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG3"]}, "metabolites": {"maltpt_c": -1.0, "glc__D_c": 1.0, "h2o_c": -1.0, "maltttr_c": 1.0}, "id": "MLTG3", "gene_reaction_rule": "ECS88_0398"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltohexaose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG4"]}, "metabolites": {"maltpt_c": 1.0, "glc__D_c": 1.0, "h2o_c": -1.0, "malthx_c": -1.0}, "id": "MLTG4", "gene_reaction_rule": "ECS88_0398"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltoheptaose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG5"]}, "metabolites": {"glc__D_c": 1.0, "malthx_c": 1.0, "h2o_c": -1.0, "malthp_c": -1.0}, "id": "MLTG5", "gene_reaction_rule": "ECS88_0398"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein4p4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY1pp"]}, "metabolites": {"murein4p4p_p": -1.0, "anhgm4p_p": 2.0}, "id": "MLTGY1pp", "gene_reaction_rule": "ECS88_2730 or ECS88_3246 or ECS88_5075 or ECS88_3082 or ECS88_2964 or ECS88_1256"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein4p3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY2pp"]}, "metabolites": {"murein4p3p_p": -1.0, "anhgm3p_p": 1.0, "anhgm4p_p": 1.0}, "id": "MLTGY2pp", "gene_reaction_rule": "ECS88_1256 or ECS88_2730 or ECS88_3246 or ECS88_5075 or ECS88_3082 or ECS88_2964"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein3p3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY3pp"]}, "metabolites": {"murein3p3p_p": -1.0, "anhgm3p_p": 2.0}, "id": "MLTGY3pp", "gene_reaction_rule": "ECS88_1256 or ECS88_3246 or ECS88_2730 or ECS88_5075 or ECS88_3082 or ECS88_2964"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein4px4p4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY4pp"]}, "metabolites": {"murein4px4p_p": 1.0, "murein4px4p4p_p": -1.0, "anhgm4p_p": 1.0}, "id": "MLTGY4pp", "gene_reaction_rule": "ECS88_2964 or ECS88_1256 or ECS88_3246 or ECS88_2730 or ECS88_5075 or ECS88_3082"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin phosphorylase (maltopentaose)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MLTP1"]}, "metabolites": {"maltpt_c": -1.0, "maltttr_c": 1.0, "pi_c": -1.0, "g1p_c": 1.0}, "id": "MLTP1", "gene_reaction_rule": "ECS88_3806"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin phosphorylase (maltohexaose)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MLTP2"]}, "metabolites": {"maltpt_c": 1.0, "pi_c": -1.0, "malthx_c": -1.0, "g1p_c": 1.0}, "id": "MLTP2", "gene_reaction_rule": "ECS88_3806"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin phosphorylase (maltoheptaose)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MLTP3"]}, "metabolites": {"malthp_c": -1.0, "pi_c": -1.0, "malthx_c": 1.0, "g1p_c": 1.0}, "id": "MLTP3", "gene_reaction_rule": "ECS88_3806"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "S-methyl-L-methionine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MMETtex"]}, "metabolites": {"mmet_e": -1.0, "mmet_p": 1.0}, "id": "MMETtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Methylmalonyl-CoA mutase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MMM"]}, "metabolites": {"mmcoa__S_c": 1.0, "succoa_c": -1.0}, "id": "MMM", "gene_reaction_rule": "scpC"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Manganese (Mn+2) transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MN2t3pp"]}, "metabolites": {"mn2_p": 1.0, "mn2_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "MN2t3pp", "gene_reaction_rule": "ECS88_4365 or ECS88_0768"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Manganese transport in via permease (no H+)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MN2tpp"]}, "metabolites": {"mn2_p": -1.0, "mn2_c": 1.0}, "id": "MN2tpp", "gene_reaction_rule": "ECS88_3437"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Mannose 6-phosphate phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MN6PP"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "man6p_c": -1.0, "man_c": 1.0}, "id": "MN6PP", "gene_reaction_rule": "ECS88_0839"}, {"subsystem": "Transport, Inner Membrane", "name": "Mannitol transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MNLptspp"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "mnl_p": -1.0, "mnl1p_c": 1.0}, "id": "MNLptspp", "gene_reaction_rule": "ECS88_4012 and ECS88_2605 and ECS88_2606"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Mannitol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MNLtex"]}, "metabolites": {"mnl_p": 1.0, "mnl_e": -1.0}, "id": "MNLtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Alternate Carbon Metabolism", "name": "D-mannonate hydrolyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MNNH"]}, "metabolites": {"h2o_c": 1.0, "2ddglcn_c": 1.0, "mana_c": -1.0}, "id": "MNNH", "gene_reaction_rule": "ECS88_4940"}, {"subsystem": "Transport, Inner Membrane", "name": "Manganese (Mn+2) transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MNt2pp"]}, "metabolites": {"mn2_p": -1.0, "mn2_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "MNt2pp", "gene_reaction_rule": "ECS88_2586"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Manganese (Mn+2) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MNtex"]}, "metabolites": {"mn2_p": 1.0, "mn2_e": -1.0}, "id": "MNtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "MoaD sulfuration (nadh, assumed)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOADSUx"]}, "metabolites": {"iscssh_c": -1.0, "moadcosh_c": 1.0, "iscs_c": 1.0, "moadamp_c": -1.0, "amp_c": 1.0, "nad_c": 1.0, "nadh_c": -1.0}, "id": "MOADSUx", "gene_reaction_rule": "ECS88_2706 and ECS88_0801"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "3-deoxy-D-manno-octulosonic acid transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOAT"]}, "metabolites": {"kdolipid4_c": 1.0, "cmp_c": 1.0, "ckdo_c": -1.0, "h_c": 1.0, "lipidA_c": -1.0}, "id": "MOAT", "gene_reaction_rule": "ECS88_4047"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "3-deoxy-D-manno-octulosonic acid 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"metabolites": {"mobd_e": -1.0, "mobd_p": 1.0}, "id": "MOBDtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Molybdopterin cytidine dinucleotide synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOCDS"]}, "metabolites": {"ctp_c": -1.0, "ppi_c": 1.0, "h_c": -1.0, "mococdp_c": 1.0, "moco_c": -1.0}, "id": "MOCDS", "gene_reaction_rule": "ECS88_3156"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Molybdenum cofactor synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOCOS"]}, "metabolites": {"cu2_c": 1.0, "h2o_c": 1.0, "mobd_c": -1.0, "moco_c": 1.0, "h_c": -2.0, "mptamp_c": -1.0, "amp_c": 1.0}, "id": "MOCOS", "gene_reaction_rule": "ECS88_0844"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Molybdopterin guanine dinucleotide synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOGDS"]}, "metabolites": {"moco_c": -1.0, "ppi_c": 1.0, "gtp_c": -1.0, "h_c": -1.0, "mocogdp_c": 1.0}, "id": "MOGDS", "gene_reaction_rule": "ECS88_4307 or (ECS88_4307 and ECS88_4306)"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "3-methyl-2-oxobutanoate hydroxymethyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOHMT"]}, "metabolites": {"thf_c": 1.0, "h2o_c": -1.0, "mlthf_c": -1.0, "2dhp_c": 1.0, "3mob_c": -1.0}, "id": "MOHMT", "gene_reaction_rule": "ECS88_0144"}, {"subsystem": "Citric Acid Cycle", "name": "Malate oxidase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MOX"]}, "metabolites": {"h2o2_c": 1.0, "mal__L_c": -1.0, "oaa_c": 1.0, "o2_c": -1.0}, "id": "MOX", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Molybdopterin adenylyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MPTAT"]}, "metabolites": {"ppi_c": 1.0, "mpt_c": -1.0, "h_c": -1.0, "atp_c": -1.0, "mptamp_c": 1.0}, "id": "MPTAT", "gene_reaction_rule": "ECS88_0010"}, {"subsystem": "Murein Biosynthesis", "name": "Murein polymerizing transglycosylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MPTG"]}, "metabolites": {"udcpdp_c": 2.0, "uaagmda_c": -2.0, "h_c": 2.0, "murein5p5p_p": 1.0}, "id": "MPTG", "gene_reaction_rule": "(ECS88_3782 and ECS88_1083) or (ECS88_0159 and ECS88_1083) or (ECS88_1083 and ECS88_2695)"}, {"subsystem": "Murein Biosynthesis", "name": "Murein polymerizing transglycosylase 2 (three linked units)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MPTG2"]}, "metabolites": {"murein5p5p5p_p": 1.0, "udcpdp_c": 1.0, "murein5p5p_p": -1.0, "h_c": 1.0, "uaagmda_c": -1.0}, "id": "MPTG2", "gene_reaction_rule": "(ECS88_3782 and ECS88_1083) or (ECS88_0159 and ECS88_1083) or (ECS88_1083 and ECS88_2695)"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Molybdopterin synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MPTS"]}, "metabolites": {"cu2_c": -1.0, "mpt_c": 1.0, "moadcosh_c": -2.0, "cpmp_c": -1.0, "h_c": 5.0, "moadcoo_c": 2.0}, "id": "MPTS", "gene_reaction_rule": "ECS88_0801 and ECS88_0802"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Molybdopterin synthase sulfurylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MPTSS"]}, "metabolites": {"moadamp_c": 1.0, "ppi_c": 1.0, "h_c": -1.0, "atp_c": -1.0, "moadcoo_c": -1.0}, "id": "MPTSS", "gene_reaction_rule": "ECS88_0843"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Malonic semialdehyde reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MSAR"]}, "metabolites": {"3hpp_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "msa_c": -1.0}, "id": "MSAR", "gene_reaction_rule": "ECS88_1024 or ECS88_1619"}, {"subsystem": "Transport, Inner Membrane", "name": "Methanesulfonate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MSO3abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "mso3_c": 1.0, "mso3_p": -1.0, "adp_c": 1.0, "pi_c": 1.0, "h_c": 1.0}, "id": "MSO3abcpp", "gene_reaction_rule": "ECS88_0964 and ECS88_0961 and ECS88_0962"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Methanesulfonate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MSO3tex"]}, "metabolites": {"mso3_e": -1.0, "mso3_p": 1.0}, "id": "MSO3tex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Methylthioadenosine nucleosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MTAN"]}, "metabolites": {"ade_c": 1.0, "5mta_c": -1.0, "5mtr_c": 1.0, "h2o_c": -1.0}, "id": "MTAN", "gene_reaction_rule": "ECS88_0170"}, {"subsystem": "Folate Metabolism", "name": "Methenyltetrahydrofolate cyclohydrolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MTHFC"]}, "metabolites": {"h2o_c": -1.0, "10fthf_c": 1.0, "h_c": 1.0, "methf_c": -1.0}, "id": "MTHFC", "gene_reaction_rule": "ECS88_0529"}, {"subsystem": "Folate Metabolism", "name": "Methylenetetrahydrofolate dehydrogenase (NADP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MTHFD"]}, "metabolites": {"nadp_c": -1.0, "nadph_c": 1.0, "methf_c": 1.0, "mlthf_c": -1.0}, "id": "MTHFD", "gene_reaction_rule": "ECS88_0529"}, {"subsystem": "Folate Metabolism", "name": "5,10-methylenetetrahydrofolate reductase (NADH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MTHFR2"]}, "metabolites": {"nad_c": 1.0, "nadh_c": -1.0, "h_c": -2.0, "mlthf_c": -1.0, "5mthf_c": 1.0}, "id": "MTHFR2", "gene_reaction_rule": "ECS88_4397"}, {"subsystem": "Methionine Metabolism", "name": "(2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran synthesis (spontaneous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MTHTHFSs"]}, "metabolites": {"h2o_c": -1.0, "mdhdhf_c": -1.0, "mththf_c": 1.0}, "id": "MTHTHFSs", "gene_reaction_rule": "s0001"}, {"subsystem": "Glycine and Serine Metabolism", "name": "N-methyltryptophan oxidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MTRPOX"]}, "metabolites": {"o2_c": -1.0, "h2o_c": -1.0, "Nmtrp_c": -1.0, "fald_c": 1.0, "h2o2_c": 1.0, "trp__L_c": 1.0}, "id": "MTRPOX", "gene_reaction_rule": "ECS88_1073"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Nitrious oxide transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["N2Otex"]}, "metabolites": {"n2o_p": 1.0, "n2o_e": -1.0}, "id": "N2Otex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Nitrious oxide transport (diffusion)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["N2Otpp"]}, "metabolites": {"n2o_c": 1.0, "n2o_p": -1.0}, "id": "N2Otpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Arginine and Proline Metabolism", "name": "N-acetylornithine deacetylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACODA"]}, "metabolites": {"glu5sa_c": 1.0, "h2o_c": -1.0, "ac_c": 1.0, "acg5sa_c": -1.0}, "id": "NACODA", "gene_reaction_rule": "ECS88_4412"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Nicotinic acid transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NACtex"]}, "metabolites": {"nac_e": -1.0, "nac_p": 1.0}, "id": "NACtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "Nicotinic acid uptake (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACtpp"]}, "metabolites": {"nac_c": 1.0, "nac_p": -1.0}, "id": "NACtpp", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NAD diphosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADDP"]}, "metabolites": {"h2o_c": -1.0, "nmn_c": 1.0, "h_c": 2.0, "nad_c": -1.0, "amp_c": 1.0}, "id": "NADDP", "gene_reaction_rule": "ECS88_4457 or ECS88_2601"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (menaquinone-8 & 0 protons)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH10"]}, "metabolites": {"nad_c": 1.0, "nadh_c": -1.0, "mqn8_c": -1.0, "h_c": -1.0, "mql8_c": 1.0}, "id": "NADH10", "gene_reaction_rule": "ECS88_1123"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (ubiquinone-8 & 3 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH16pp"]}, "metabolites": {"h_p": 3.0, "q8h2_c": 1.0, "h_c": -4.0, "nad_c": 1.0, "nadh_c": -1.0, "q8_c": -1.0}, "id": "NADH16pp", "gene_reaction_rule": "ECS88_2423 and ECS88_2424 and ECS88_2425 and ECS88_2426 and ECS88_2427 and ECS88_2428 and ECS88_2429 and ECS88_2430 and ECS88_2431 and ECS88_2432 and ECS88_2433 and ECS88_2434 and ECS88_2435"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (menaquinone-8 & 3 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH17pp"]}, "metabolites": {"mqn8_c": -1.0, "h_p": 3.0, "h_c": -4.0, "nad_c": 1.0, "nadh_c": -1.0, "mql8_c": 1.0}, "id": "NADH17pp", "gene_reaction_rule": "ECS88_2423 and ECS88_2424 and ECS88_2425 and ECS88_2426 and ECS88_2427 and ECS88_2428 and ECS88_2429 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Phosphorylation", "name": "NADH dehydrogenase (demethylmenaquinone-8 & 0 protons)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH9"]}, "metabolites": {"nadh_c": -1.0, "2dmmql8_c": 1.0, "2dmmq8_c": -1.0, "nad_c": 1.0, "h_c": -1.0}, "id": "NADH9", "gene_reaction_rule": "ECS88_1123"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NAD kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADK"]}, "metabolites": {"h_c": 1.0, "nadp_c": 1.0, "nad_c": -1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "NADK", "gene_reaction_rule": "ECS88_2801"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NAD nucleosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADN"]}, "metabolites": {"h2o_c": -1.0, "adprib_c": 1.0, "h_c": 1.0, "nad_c": -1.0, "ncam_c": 1.0}, "id": "NADN", "gene_reaction_rule": ""}, {"subsystem": "Oxidative Phosphorylation", "name": "NADPH Quinone Reductase (Ubiquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPHQR2"]}, "metabolites": {"q8h2_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "q8_c": -1.0, "h_c": -1.0}, "id": "NADPHQR2", "gene_reaction_rule": "ECS88_3416"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADPH Quinone Reductase (Menaquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPHQR3"]}, "metabolites": {"nadph_c": -1.0, "nadp_c": 1.0, "mqn8_c": -1.0, "h_c": -1.0, "mql8_c": 1.0}, "id": "NADPHQR3", "gene_reaction_rule": "ECS88_3416"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADPH Quinone Reductase (2-Demethylmenaquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPHQR4"]}, "metabolites": {"nadp_c": 1.0, "nadph_c": -1.0, "2dmmq8_c": -1.0, "2dmmql8_c": 1.0, "h_c": -1.0}, "id": "NADPHQR4", "gene_reaction_rule": "ECS88_3416"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NADP phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPPPS"]}, "metabolites": {"h2o_c": -1.0, "nadp_c": -1.0, "pi_c": 1.0, "nad_c": 1.0}, "id": "NADPPPS", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NAD synthase (nh3)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADS1"]}, "metabolites": {"dnad_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "h_c": 1.0, "nad_c": 1.0, "nh4_c": -1.0, "amp_c": 1.0}, "id": "NADS1", "gene_reaction_rule": "ECS88_1792"}, {"subsystem": "Oxidative Phosphorylation", "name": "NAD transhydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADTRHD"]}, "metabolites": {"nadph_c": -1.0, "nadh_c": 1.0, "nadp_c": 1.0, "nad_c": -1.0}, "id": "NADTRHD", "gene_reaction_rule": "ECS88_4419 or (ECS88_1647 and ECS88_1648)"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Nicotinic acid mononucleotide pyrophosphorylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAMNPP"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "nicrnt_c": 1.0, "ppi_c": 1.0, "nac_c": -1.0, "adp_c": 1.0, "pi_c": 1.0, "prpp_c": -1.0}, "id": "NAMNPP", "gene_reaction_rule": "ECS88_0959"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Sodium proton antiporter (H:NA is 1.5) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAt3_1p5pp"]}, "metabolites": {"na1_p": 2.0, "na1_c": -2.0, "h_c": 3.0, "h_p": -3.0}, "id": "NAt3_1p5pp", "gene_reaction_rule": "ECS88_1249"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Sodium proton antiporter (H:NA is 2) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAt3_2pp"]}, "metabolites": {"na1_p": 1.0, "na1_c": -1.0, "h_c": 2.0, "h_p": -2.0}, "id": "NAt3_2pp", "gene_reaction_rule": "ECS88_0020"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Sodium transport out via proton antiport (cytoplasm to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAt3pp"]}, "metabolites": {"na1_p": 1.0, "na1_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "NAt3pp", "gene_reaction_rule": "ECS88_0859 or ECS88_1285"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Sodium transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NAtex"]}, "metabolites": {"na1_p": 1.0, "na1_e": -1.0}, "id": "NAtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:GDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK1"]}, "metabolites": {"gtp_c": 1.0, "gdp_c": -1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "NDPK1", "gene_reaction_rule": "ECS88_0471 or ECS88_2694"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:UDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK2"]}, "metabolites": {"utp_c": 1.0, "udp_c": -1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "NDPK2", "gene_reaction_rule": "ECS88_0471 or ECS88_2694"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:CDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK3"]}, "metabolites": {"ctp_c": 1.0, "cdp_c": -1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "NDPK3", "gene_reaction_rule": "ECS88_2694 or ECS88_0471"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:dTDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK4"]}, "metabolites": {"dttp_c": 1.0, "dtdp_c": -1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "NDPK4", "gene_reaction_rule": "ECS88_0471 or ECS88_2694"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:dGDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK5"]}, "metabolites": {"dgtp_c": 1.0, "dgdp_c": -1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "NDPK5", "gene_reaction_rule": "ECS88_0471 or ECS88_2694"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:dUDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK6"]}, "metabolites": {"dutp_c": 1.0, "adp_c": 1.0, "atp_c": -1.0, "dudp_c": -1.0}, "id": "NDPK6", "gene_reaction_rule": "ECS88_2694 or ECS88_0471"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:dCDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK7"]}, "metabolites": {"dcdp_c": -1.0, "adp_c": 1.0, "atp_c": -1.0, "dctp_c": 1.0}, "id": "NDPK7", "gene_reaction_rule": "ECS88_0471 or ECS88_2694"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:dADP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK8"]}, "metabolites": {"dadp_c": -1.0, "atp_c": -1.0, "adp_c": 1.0, "datp_c": 1.0}, "id": "NDPK8", "gene_reaction_rule": "ECS88_0471 or ECS88_2694"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Ammonia transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NH4tex"]}, "metabolites": {"nh4_e": -1.0, "nh4_p": 1.0}, "id": "NH4tex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Ammonia reversible transport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NH4tpp"]}, "metabolites": {"nh4_c": 1.0, "nh4_p": -1.0}, "id": "NH4tpp", "gene_reaction_rule": "ECS88_0448 or s0001"}, {"subsystem": "Nitrogen Metabolism", "name": "NADH:flavorubredoxin oxidoreductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NHFRBO"]}, "metabolites": {"h2o_c": 1.0, "h_c": -1.0, "nad_c": 1.0, "no_c": -2.0, "n2o_c": 1.0, "nadh_c": -1.0}, "id": "NHFRBO", "gene_reaction_rule": "ECS88_2973 and ECS88_2974"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Nickle (Ni+2) ABC transporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NI2abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "ni2_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "ni2_p": 1.0}, "id": "NI2abcpp", "gene_reaction_rule": "ECS88_3872"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Nickle (Ni+2) transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NI2t3pp"]}, "metabolites": {"ni2_c": -1.0, "h_c": 1.0, "h_p": -1.0, "ni2_p": 1.0}, "id": "NI2t3pp", "gene_reaction_rule": "ECS88_4365 or ECS88_0768"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Nickel transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NI2tex"]}, "metabolites": {"ni2_e": -1.0, "ni2_p": 1.0}, "id": "NI2tex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Nickel (+2) transport in via permease (no H+)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NI2tpp"]}, "metabolites": {"ni2_c": 1.0, "ni2_p": -1.0}, "id": "NI2tpp", "gene_reaction_rule": "ECS88_4242"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Nickel transport via ABC system (uptake, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NI2uabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "ni2_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "ni2_p": -1.0}, "id": "NI2uabcpp", "gene_reaction_rule": "(ECS88_3879 and ECS88_3880 and ECS88_3881 and ECS88_3882 and ECS88_3883) or ECS88_4832"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Nicotinamide-nucleotide adenylyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NMNAT"]}, "metabolites": {"ppi_c": 1.0, "nmn_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "atp_c": -1.0}, "id": "NMNAT", "gene_reaction_rule": "ECS88_5071 or ECS88_0681"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Nicotinamide-nucleotide amidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NMNDA"]}, "metabolites": {"nicrnt_c": 1.0, "h2o_c": -1.0, "nmn_c": -1.0, "nh4_c": 1.0}, "id": "NMNDA", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NMN nucleosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NMNN"]}, "metabolites": {"h2o_c": -1.0, "r5p_c": 1.0, "nmn_c": -1.0, "h_c": 1.0, "ncam_c": 1.0}, "id": "NMNN", "gene_reaction_rule": ""}, {"subsystem": "Transport, Inner Membrane", "name": "NMN permease (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NMNPtpp"]}, "metabolites": {"nmn_c": 1.0, "nmn_p": -1.0}, "id": "NMNPtpp", "gene_reaction_rule": "ECS88_0767"}, {"subsystem": "Transport, Inner Membrane", "name": "NMN transport via NMN glycohydrolase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NMNt7pp"]}, "metabolites": {"h2o_c": -1.0, "ncam_c": 1.0, "r5p_c": 1.0, "h_c": 1.0, "nmn_p": -1.0}, "id": "NMNt7pp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "NMN transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NMNtex"]}, "metabolites": {"nmn_e": -1.0, "nmn_p": 1.0}, "id": "NMNtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Nicotinamidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NNAM"]}, "metabolites": {"h2o_c": -1.0, "ncam_c": -1.0, "nac_c": 1.0, "nh4_c": 1.0}, "id": "NNAM", "gene_reaction_rule": "ECS88_1820"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nicotinate-nucleotide adenylyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NNATr"]}, "metabolites": {"nicrnt_c": -1.0, "dnad_c": 1.0, "ppi_c": 1.0, "h_c": -1.0, "atp_c": -1.0}, "id": "NNATr", "gene_reaction_rule": "ECS88_0681"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Nicotinate-nucleotide dimethylbenzimidazole phosphoribosyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NNDMBRT"]}, "metabolites": {"dmbzid_c": -1.0, "5prdmbz_c": 1.0, "nicrnt_c": -1.0, "h_c": 1.0, "nac_c": 1.0}, "id": "NNDMBRT", "gene_reaction_rule": "ECS88_2056"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Nicotinate-nucleotide diphosphorylase (carboxylating)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NNDPR"]}, "metabolites": {"nicrnt_c": 1.0, "ppi_c": 1.0, "quln_c": -1.0, "h_c": -2.0, "co2_c": 1.0, "prpp_c": -1.0}, "id": "NNDPR", "gene_reaction_rule": "ECS88_0111"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Nitrite transport in via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NO2t2rpp"]}, "metabolites": {"h_p": -1.0, "h_c": 1.0, "no2_c": 1.0, "no2_p": -1.0}, "id": "NO2t2rpp", "gene_reaction_rule": "ECS88_3758 or ECS88_1293"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Nitrite transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NO2tex"]}, "metabolites": {"no2_e": -1.0, "no2_p": 1.0}, "id": "NO2tex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Nitrogen Metabolism", "name": "Nitrate reductase (Ubiquinol-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NO3R1bpp"]}, "metabolites": {"h2o_p": 1.0, "q8h2_c": -1.0, "no3_p": -1.0, "q8_c": 1.0, "no2_p": 1.0}, "id": "NO3R1bpp", "gene_reaction_rule": "(ECS88_2350 and ECS88_2353) and ECS88_2349 and ECS88_2352 and ECS88_2351"}, {"subsystem": "Oxidative Phosphorylation", "name": "Nitrate reductase (Ubiquinol-8) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NO3R1pp"]}, "metabolites": {"h2o_c": 1.0, "h_p": 2.0, "no3_c": -1.0, "q8h2_c": -1.0, "h_c": -2.0, "q8_c": 1.0, "no2_c": 1.0}, "id": "NO3R1pp", "gene_reaction_rule": "(ECS88_1560 and ECS88_1561 and ECS88_1295 and ECS88_1294) or (ECS88_1294 and ECS88_1295 and ECS88_1296 and ECS88_1297)"}, {"subsystem": "Nitrogen Metabolism", "name": "Nitrate reductase (Menaquinol-8) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NO3R2bpp"]}, "metabolites": {"h2o_p": 1.0, "no3_p": -1.0, "mql8_c": -1.0, "mqn8_c": 1.0, "no2_p": 1.0}, "id": "NO3R2bpp", "gene_reaction_rule": "(ECS88_2350 and ECS88_2353) and ECS88_2349"}, {"subsystem": "Oxidative Phosphorylation", "name": "Nitrate reductase (Menaquinol-8) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NO3R2pp"]}, "metabolites": {"h2o_c": 1.0, "mqn8_c": 1.0, "h_p": 2.0, "no3_c": -1.0, "mql8_c": -1.0, "h_c": -2.0, "no2_c": 1.0}, "id": "NO3R2pp", "gene_reaction_rule": "(ECS88_1560 and ECS88_1561 and ECS88_1295 and ECS88_1294) or (ECS88_1294 and ECS88_1295 and ECS88_1296 and ECS88_1297)"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Nitrate transport in via nitrite antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NO3t7pp"]}, "metabolites": {"no3_p": -1.0, "no2_p": 1.0, "no2_c": -1.0, "no3_c": 1.0}, "id": "NO3t7pp", "gene_reaction_rule": "ECS88_1293"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Nitrate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NO3tex"]}, "metabolites": {"no3_e": -1.0, "no3_p": 1.0}, "id": "NO3tex", "gene_reaction_rule": "ECS88_1492 or ECS88_0276 or ECS88_0957 or ECS88_2364"}, {"subsystem": "Nitrogen Metabolism", "name": "Nitric oxide dioxygenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NODOx"]}, "metabolites": {"o2_c": -2.0, "no3_c": 2.0, "h_c": 1.0, "nad_c": 1.0, "no_c": -2.0, "nadh_c": -1.0}, "id": "NODOx", "gene_reaction_rule": "ECS88_2723"}, {"subsystem": "Nitrogen Metabolism", "name": "Nitric oxide dioxygenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NODOy"]}, "metabolites": {"o2_c": -2.0, "nadp_c": 1.0, "nadph_c": -1.0, "no3_c": 2.0, "h_c": 1.0, "no_c": -2.0}, "id": "NODOy", "gene_reaction_rule": "ECS88_2723"}, {"subsystem": "Transport, Outer Membrane", "name": "Novobiocin transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NOVBCNtex"]}, "metabolites": {"novbcn_e": -1.0, "novbcn_p": 1.0}, "id": "NOVBCNtex", "gene_reaction_rule": "s0001"}, {"subsystem": "Transport, Outer Membrane", "name": "Novobiocin transport via TolC system", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NOVBCNtpp"]}, "metabolites": {"novbcn_e": 1.0, "h_c": 1.0, "h_p": -1.0, "novbcn_p": -1.0}, "id": "NOVBCNtpp", "gene_reaction_rule": "ECS88_0460 and ECS88_2649 and ECS88_3429"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Nitric oxide transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, 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"2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OMMBLHX"]}, "metabolites": {"o2_c": -0.5, "2omhmbl_c": 1.0, "2ommbl_c": -1.0}, "id": "OMMBLHX", "gene_reaction_rule": "ECS88_0697"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase (anaerobic)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OMMBLHX3"]}, "metabolites": {"2omhmbl_c": 1.0, "pi_c": 2.0, "nad_c": -1.0, "atp_c": -2.0, "h2o_c": -3.0, "2ommbl_c": -1.0, "h_c": 3.0, "adp_c": 2.0, "nadh_c": 1.0}, "id": "OMMBLHX3", "gene_reaction_rule": ""}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Orotidine-5'-phosphate decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OMPDC"]}, "metabolites": {"ump_c": 1.0, "co2_c": 1.0, "h_c": -1.0, "orot5p_c": -1.0}, "id": "OMPDC", "gene_reaction_rule": 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"PE161abcpp", "gene_reaction_rule": "ECS88_0942"}, {"subsystem": "Transport, Inner Membrane", "name": "Phosphatidylethanolamine transport via ABC system (n-C18:0, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PE180abcpp"]}, "metabolites": {"h2o_c": -1.0, "pe180_c": -1.0, "atp_c": -1.0, "pe180_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "PE180abcpp", "gene_reaction_rule": "ECS88_0942"}, {"subsystem": "Transport, Inner Membrane", "name": "Phosphatidylethanolamine transport via ABC system (n-C18:1, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PE181abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "pe181_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "pe181_c": -1.0, "pi_c": 1.0}, "id": "PE181abcpp", "gene_reaction_rule": "ECS88_0942"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Phenethylamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 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"Transport, Outer Membrane Porin", "name": "Propionate transport via diffusion", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PPAtex"]}, "metabolites": {"ppa_p": 1.0, "ppa_e": -1.0}, "id": "PPAtex", "gene_reaction_rule": "ECS88_1492 or ECS88_0957 or ECS88_2364 or ECS88_0276"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Porphobilinogen synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPBNGS"]}, "metabolites": {"ppbng_c": 1.0, "5aop_c": -2.0, "h_c": 1.0, "h2o_c": 2.0}, "id": "PPBNGS", "gene_reaction_rule": "ECS88_0366"}, {"subsystem": "Anaplerotic Reactions", "name": "Phosphoenolpyruvate carboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPC"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "pep_c": -1.0, "h_c": 1.0, "oaa_c": 1.0, "co2_c": -1.0}, "id": "PPC", "gene_reaction_rule": "ECS88_4411"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Phosphopantothenoylcysteine decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPCDC"]}, "metabolites": {"pan4p_c": 1.0, "co2_c": 1.0, "h_c": -1.0, "4ppcys_c": -1.0}, "id": "PPCDC", "gene_reaction_rule": "ECS88_4053"}, {"subsystem": "Anaplerotic Reactions", "name": "Phosphoenolpyruvate carboxykinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPCK"]}, "metabolites": {"pep_c": 1.0, "co2_c": 1.0, "oaa_c": -1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "PPCK", "gene_reaction_rule": "ECS88_3790"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Propanoyl-CoA: succinate CoA-transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPCSCT"]}, "metabolites": {"ppa_c": 1.0, "succoa_c": 1.0, "succ_c": -1.0, "ppcoa_c": -1.0}, "id": "PPCSCT", "gene_reaction_rule": "scpC"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Guanosine-3',5'-bis(diphosphate) 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{"r5p_c": 1.0, "r1p_c": -1.0}, "id": "PPM", "gene_reaction_rule": "ECS88_3765 or ECS88_5064"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Phosphopentomutase 2 (deoxyribose)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PPM2"]}, "metabolites": {"2dr1p_c": -1.0, "2dr5p_c": 1.0}, "id": "PPM2", "gene_reaction_rule": "ECS88_5064"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Phosphopantothenate-cysteine ligase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPNCL2"]}, "metabolites": {"cys__L_c": -1.0, "cmp_c": 1.0, "ppi_c": 1.0, "4ppcys_c": 1.0, "ctp_c": -1.0, "h_c": 1.0, "4ppan_c": -1.0}, "id": "PPNCL2", "gene_reaction_rule": "ECS88_4053"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Prephenate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPND"]}, "metabolites": {"pphn_c": -1.0, "34hpp_c": 1.0, "co2_c": 1.0, 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-1.0, "pyr_c": -1.0, "pep_c": 1.0, "h_c": 2.0, "pi_c": 1.0, "amp_c": 1.0}, "id": "PPS", "gene_reaction_rule": "ECS88_1753"}, {"subsystem": "Unassigned", "name": "Phosphonate hydrogenase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPTHpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "ppt_p": -1.0, "h2_p": 1.0}, "id": "PPTHpp", "gene_reaction_rule": "ECS88_0377"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Phosphonate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PPTtex"]}, "metabolites": {"ppt_e": -1.0, "ppt_p": 1.0}, "id": "PPTtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylglycinamide synthase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PRAGSr"]}, "metabolites": {"pram_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "gar_c": 1.0, "pi_c": 1.0, "gly_c": -1.0}, "id": "PRAGSr", "gene_reaction_rule": "ECS88_4466"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylaminoimidazole synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PRAIS"]}, "metabolites": {"atp_c": -1.0, "fpram_c": -1.0, "h_c": 2.0, "adp_c": 1.0, "air_c": 1.0, "pi_c": 1.0}, "id": "PRAIS", "gene_reaction_rule": "ECS88_2671"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Phosphoribosylanthranilate isomerase (irreversible)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PRAIi"]}, "metabolites": {"2cpr5p_c": 1.0, "pran_c": -1.0}, "id": "PRAIi", "gene_reaction_rule": "ECS88_1397"}, {"subsystem": "Histidine Metabolism", "name": "Phosphoribosyl-AMP cyclohydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PRAMPC"]}, "metabolites": {"prfp_c": 1.0, "h2o_c": -1.0, "prbamp_c": -1.0}, "id": "PRAMPC", "gene_reaction_rule": "ECS88_2125"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylaminoimidazolesuccinocarboxamide synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PRASCSi", "PRASCS"]}, "metabolites": {"atp_c": -1.0, "5aizc_c": -1.0, "asp__L_c": -1.0, "25aics_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "PRASCSi_copy1", "gene_reaction_rule": "ECS88_2658"}, {"subsystem": "Histidine Metabolism", "name": "Phosphoribosyl-ATP pyrophosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PRATPP"]}, "metabolites": {"h2o_c": -1.0, "ppi_c": 1.0, "prbamp_c": 1.0, "h_c": 1.0, "prbatp_c": -1.0}, "id": "PRATPP", "gene_reaction_rule": "ECS88_2125"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylformylglycinamidine synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PRFGS"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "glu__L_c": 1.0, "fgam_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "fpram_c": 1.0, "pi_c": 1.0, "gln__L_c": -1.0}, "id": "PRFGS", "gene_reaction_rule": "ECS88_2729"}, {"subsystem": "Histidine Metabolism", "name": "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PRMICI"]}, "metabolites": {"prfp_c": -1.0, "prlp_c": 1.0}, "id": "PRMICI", "gene_reaction_rule": "ECS88_2123"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Proline dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PROD2"]}, "metabolites": {"1pyr5c_c": 1.0, "fadh2_c": 1.0, "pro__L_c": -1.0, "h_c": 1.0, "fad_c": -1.0}, "id": "PROD2", "gene_reaction_rule": "ECS88_1030"}, {"subsystem": "Transport, Inner Membrane", "name": "L-Prolinylglycine (Pro-Gly) transport via ABC system (periplasm)", "upper_bound": 1000.0, 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"ECS88_0206"}, {"subsystem": "Transport, Inner Membrane", "name": "L-proline transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PROabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "pro__L_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pro__L_p": -1.0, "pi_c": 1.0}, "id": "PROabcpp", "gene_reaction_rule": "ECS88_2943 and ECS88_2944 and ECS88_2945"}, {"subsystem": "Transport, Inner Membrane", "name": "L-proline reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PROt2rpp"]}, "metabolites": {"pro__L_p": -1.0, "pro__L_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "PROt2rpp", "gene_reaction_rule": "ECS88_4612"}, {"subsystem": "Transport, Inner Membrane", "name": "Na+/Proline-L symporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PROt4pp"]}, "metabolites": {"na1_p": -1.0, "pro__L_p": -1.0, "pro__L_c": 1.0, 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{"subsystem": "Arginine and Proline Metabolism", "name": "Putrescine Transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PTRCTA"]}, "metabolites": {"akg_c": -1.0, "ptrc_c": -1.0, "glu__L_c": 1.0, "4abutn_c": 1.0}, "id": "PTRCTA", "gene_reaction_rule": "ECS88_3470"}, {"subsystem": "Transport, Inner Membrane", "name": "Putrescine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PTRCabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "ptrc_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "ptrc_c": 1.0, "pi_c": 1.0}, "id": "PTRCabcpp", "gene_reaction_rule": "(ECS88_0871 and ECS88_0872 and ECS88_0873 and ECS88_0874) or (ECS88_1140 and ECS88_1139 and ECS88_1138 and ECS88_1137) or (ECS88_1533 and ECS88_1534 and ECS88_1536 and ECS88_1537)"}, {"subsystem": "Transport, Inner Membrane", "name": "Putrescine transport in via proton symport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": 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-1.0, "h2o_c": 2.0, "dmlz_c": 1.0, "pi_c": 1.0, "db4p_c": -1.0}, "id": "RBFSa", "gene_reaction_rule": "ECS88_1711"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Riboflavin synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RBFSb"]}, "metabolites": {"4r5au_c": 1.0, "dmlz_c": -2.0, "ribflv_c": 1.0}, "id": "RBFSb", "gene_reaction_rule": "ECS88_0410"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Ribokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RBK"]}, "metabolites": {"h_c": 1.0, "r5p_c": 1.0, "rib__D_c": -1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "RBK", "gene_reaction_rule": "ECS88_4174"}, {"subsystem": "Alternate Carbon Metabolism", "name": "L-ribulokinase (L-ribulose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RBK_L1"]}, "metabolites": {"rbl__L_c": -1.0, "h_c": 1.0, "ru5p__L_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "RBK_L1", "gene_reaction_rule": "ECS88_0066"}, {"subsystem": "Alternate Carbon Metabolism", "name": "L-ribulose-phosphate 4-epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["RBP4E"]}, "metabolites": {"xu5p__D_c": 1.0, "ru5p__L_c": -1.0}, "id": "RBP4E", "gene_reaction_rule": "ECS88_4784 or ECS88_4003 or ECS88_0064"}, {"subsystem": "Transport, Outer Membrane", "name": "Rifampin transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["RFAMPtex"]}, "metabolites": {"rfamp_e": -1.0, "rfamp_p": 1.0}, "id": "RFAMPtex", "gene_reaction_rule": "s0001"}, {"subsystem": "Transport, Outer Membrane", "name": "Rifampin transport via TolC system", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RFAMPtpp"]}, "metabolites": {"rfamp_e": 1.0, "rfamp_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "RFAMPtpp", "gene_reaction_rule": "ECS88_0460 and ECS88_2649 and ECS88_3429"}, {"subsystem": "Methionine Metabolism", "name": "S-ribosylhomocysteine cleavage enzyme", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RHCCE"]}, "metabolites": {"hcys__L_c": 1.0, "rhcys_c": -1.0, "dhptd_c": 1.0}, "id": "RHCCE", "gene_reaction_rule": "ECS88_2954"}, {"subsystem": "Transport, Inner Membrane", "name": "D-ribose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RIBabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "rib__D_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "rib__D_c": 1.0}, "id": "RIBabcpp", "gene_reaction_rule": "(ECS88_4821 and ECS88_4818 and ECS88_4819 and ECS88_4820) or (ECS88_4171 and ECS88_4173 and ECS88_4172 and ECS88_4170)"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Ribose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["RIBtex"]}, "metabolites": {"rib__D_e": -1.0, "rib__D_p": 1.0}, "id": "RIBtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Alternate Carbon Metabolism", "name": "L-rhamnose isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["RMI"]}, "metabolites": {"rmn_c": -1.0, "rml_c": 1.0}, "id": "RMI", "gene_reaction_rule": "ECS88_4350"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Rhamnulokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RMK"]}, "metabolites": {"adp_c": 1.0, "rml1p_c": 1.0, "rml_c": -1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "RMK", "gene_reaction_rule": "ECS88_4351"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-rhamnose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["RMNtex"]}, "metabolites": {"rmn_p": 1.0, "rmn_e": -1.0}, "id": "RMNtex", "gene_reaction_rule": "ECS88_2364 or 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and ECS88_2757) or ((ECS88_2382 and ECS88_2383) and ECS88_4203)"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Ribonucleoside-diphosphate reductase (ADP) (glutaredoxin)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RNDR1b"]}, "metabolites": {"dadp_c": 1.0, "h2o_c": 1.0, "grxrd_c": -1.0, "adp_c": -1.0, "grxox_c": 1.0}, "id": "RNDR1b", "gene_reaction_rule": "(ECS88_1078 and (ECS88_2941 and ECS88_2942)) or (ECS88_4027 and (ECS88_2941 and ECS88_2942)) or (ECS88_1703 and (ECS88_2941 and ECS88_2942)) or (ECS88_0866 and (ECS88_2941 and ECS88_2942))"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Ribonucleoside-diphosphate reductase (GDP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RNDR2"]}, "metabolites": {"trdox_c": 1.0, "dgdp_c": 1.0, "gdp_c": -1.0, "h2o_c": 1.0, "trdrd_c": -1.0}, "id": "RNDR2", "gene_reaction_rule": "((ECS88_2382 and ECS88_2383) and ECS88_4203) or ((ECS88_2382 and ECS88_2383) and 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"sbt__D_p": -1.0, "sbt6p_c": 1.0}, "id": "SBTptspp", "gene_reaction_rule": "ECS88_2605 and ECS88_2606 and ECS88_2965 and ECS88_2967 and ECS88_2966"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-sorbitol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SBTtex"]}, "metabolites": {"sbt__D_e": -1.0, "sbt__D_p": 1.0}, "id": "SBTtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "SUF Cysteine desulfuration", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SCYSDS"]}, "metabolites": {"cys__L_c": -1.0, "ala__L_c": 1.0, "sufsesh_c": 1.0, "sufse_c": -1.0}, "id": "SCYSDS", "gene_reaction_rule": "ECS88_1729 and ECS88_1730"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Succinyl-diaminopimelate desuccinylase", "upper_bound": 1000.0, "lower_bound": 0.0, 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"metabolites": {"dgslnt_c": 1.0, "h2o_c": 3.0, "h_c": -2.0, "slnt_c": -1.0, "gthrd_c": -4.0, "gthox_c": 1.0}, "id": "SELGTHR", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Selenate glutathione reductase II", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SELGTHR2"]}, "metabolites": {"dgslnt_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "gslnt_c": 1.0, "h_c": -1.0, "gthrd_c": 1.0}, "id": "SELGTHR2", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Selenate glutathione reductase III", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SELGTHR3"]}, "metabolites": {"gslnt_c": -1.0, "gthrd_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "seln_c": 1.0}, "id": "SELGTHR3", "gene_reaction_rule": ""}, {"subsystem": "Unassigned", "name": "Selenophosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SELNPS"]}, "metabolites": {"seln_c": -1.0, "atp_c": -1.0, "h2o_c": -1.0, "selnp_c": 1.0, "amp_c": 1.0, "pi_c": 1.0}, "id": "SELNPS", "gene_reaction_rule": "ECS88_1814"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Selenate reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SELR"]}, "metabolites": {"h2o_c": 1.0, "slnt_c": 1.0, "mqn8_c": 1.0, "mql8_c": -1.0, "sel_c": -1.0}, "id": "SELR", "gene_reaction_rule": "ECS88_1632 and ECS88_1633 and ECS88_1634 and ECS88_1635"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Selenate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SELtex"]}, "metabolites": {"sel_p": 1.0, "sel_e": -1.0}, "id": "SELtex", "gene_reaction_rule": "ECS88_1492 or ECS88_0957 or ECS88_2364 or ECS88_0276"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Selenate transport via proton symport (periplasm)", "upper_bound": 1000.0, 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"Serine O-acetyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SERAT"]}, "metabolites": {"ser__L_c": -1.0, "acser_c": 1.0, "coa_c": 1.0, "accoa_c": -1.0}, "id": "SERAT", "gene_reaction_rule": "ECS88_4024"}, {"subsystem": "Glycine and Serine Metabolism", "name": "D-serine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SERD_D"]}, "metabolites": {"ser__D_c": -1.0, "pyr_c": 1.0, "nh4_c": 1.0}, "id": "SERD_D", "gene_reaction_rule": "ECS88_2560"}, {"subsystem": "Glycine and Serine Metabolism", "name": "L-serine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SERD_L"]}, "metabolites": {"pyr_c": 1.0, "ser__L_c": -1.0, "nh4_c": 1.0}, "id": "SERD_L", "gene_reaction_rule": "ECS88_3505 or ECS88_1866 or ECS88_1866 or ECS88_4131"}, {"subsystem": "tRNA Charging", "name": "Seryl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SERTRS"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "sertrna_c": 1.0, "ser__L_c": -1.0, "amp_c": 1.0, "trnaser_c": -1.0}, "id": "SERTRS", "gene_reaction_rule": "ECS88_0924"}, {"subsystem": "tRNA Charging", "name": "Seryl-tRNA synthetase (selenocystein)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SERTRS2"]}, "metabolites": {"trnasecys_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "ser__L_c": -1.0, "sertrna_sec_c": 1.0, "amp_c": 1.0}, "id": "SERTRS2", "gene_reaction_rule": "ECS88_0924"}, {"subsystem": "Transport, Inner Membrane", "name": "L-serine reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SERt2rpp"]}, "metabolites": {"ser__L_p": -1.0, "ser__L_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "SERt2rpp", "gene_reaction_rule": "ECS88_3065 or ECS88_3509"}, {"subsystem": "Transport, Inner Membrane", "name": "L-serine via sodium symport (periplasm)", "upper_bound": 1000.0, 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dehydrogenase (NAD)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SHCHD2"]}, "metabolites": {"dscl_c": -1.0, "nadh_c": 1.0, "scl_c": 1.0, "nad_c": -1.0, "h_c": 1.0}, "id": "SHCHD2", "gene_reaction_rule": "ECS88_3759"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Sirohydrochlorin ferrochelatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SHCHF"]}, "metabolites": {"fe2_c": -1.0, "sheme_c": 1.0, "scl_c": -1.0, "h_c": 3.0}, "id": "SHCHF", "gene_reaction_rule": "ECS88_3759"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Shikimate dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SHK3Dr"]}, "metabolites": {"3dhsk_c": -1.0, "skm_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0}, "id": "SHK3Dr", "gene_reaction_rule": "ECS88_1742 or ECS88_3669"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Shikimate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SHKK"]}, "metabolites": {"atp_c": -1.0, "skm_c": -1.0, "skm5p_c": 1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "SHKK", "gene_reaction_rule": "ECS88_3775 or ECS88_0383"}, {"subsystem": "Methionine Metabolism", "name": "O-succinylhomoserine lyase (L-cysteine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SHSL1"]}, "metabolites": {"cys__L_c": -1.0, "succ_c": 1.0, "suchms_c": -1.0, "h_c": 1.0, "cyst__L_c": 1.0}, "id": "SHSL1", "gene_reaction_rule": "ECS88_4390"}, {"subsystem": "Transport, Inner Membrane", "name": "Shikimate transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SKMt2pp"]}, "metabolites": {"skm_c": 1.0, "h_c": 1.0, "h_p": -1.0, "skm_p": -1.0}, "id": "SKMt2pp", "gene_reaction_rule": "ECS88_2049"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Shikimate transport via diffusion 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{"subsystem": "Transport, Outer Membrane Porin", "name": "SO2 transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SO2tex"]}, "metabolites": {"so2_p": 1.0, "so2_e": -1.0}, "id": "SO2tex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "SO2 transport via diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SO2tpp"]}, "metabolites": {"so2_p": -1.0, "so2_c": 1.0}, "id": "SO2tpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Sulfite transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SO3tex"]}, "metabolites": {"so3_p": 1.0, "so3_e": -1.0}, "id": "SO3tex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Sulfate transport in via proton symport (periplasm to cytoplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SO4t2pp"]}, "metabolites": {"so4_c": 1.0, "so4_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "SO4t2pp", "gene_reaction_rule": "ECS88_1274"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Sulfate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SO4tex"]}, "metabolites": {"so4_p": 1.0, "so4_e": -1.0}, "id": "SO4tex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Succinylornithine transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SOTA"]}, "metabolites": {"akg_c": -1.0, "sucorn_c": -1.0, "glu__L_c": 1.0, "sucgsa_c": 1.0}, "id": "SOTA", "gene_reaction_rule": 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"upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THRA2i"]}, "metabolites": {"acald_c": 1.0, "gly_c": 1.0, "athr__L_c": -1.0}, "id": "THRA2i", "gene_reaction_rule": "ECS88_2721 or ECS88_0891"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Threonine aldolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THRAi"]}, "metabolites": {"acald_c": 1.0, "thr__L_c": -1.0, "gly_c": 1.0}, "id": "THRAi", "gene_reaction_rule": "ECS88_2721 or ECS88_0891"}, {"subsystem": "Glycine and Serine Metabolism", "name": "L-threonine dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THRD"]}, "metabolites": {"thr__L_c": -1.0, "nadh_c": 1.0, "2aobut_c": 1.0, "nad_c": -1.0, "h_c": 1.0}, "id": "THRD", "gene_reaction_rule": "ECS88_4033"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "L-threonine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THRD_L"]}, "metabolites": {"thr__L_c": -1.0, "2obut_c": 1.0, "nh4_c": 1.0}, "id": "THRD_L", "gene_reaction_rule": "ECS88_3510 or ECS88_4195"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Phospho-L-threonine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["THRPtex"]}, "metabolites": {"thrp_e": -1.0, "thrp_p": 1.0}, "id": "THRPtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Threonine synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THRS"]}, "metabolites": {"phom_c": -1.0, "thr__L_c": 1.0, "pi_c": 1.0, "h2o_c": -1.0}, "id": "THRS", "gene_reaction_rule": "ECS88_0004"}, {"subsystem": "tRNA Charging", "name": "Threonyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THRTRS"]}, "metabolites": {"atp_c": -1.0, "thrtrna_c": 1.0, "ppi_c": 1.0, "amp_c": 1.0, "thr__L_c": -1.0, "trnathr_c": -1.0}, "id": "THRTRS", "gene_reaction_rule": "ECS88_1769"}, {"subsystem": "Transport, Inner Membrane", "name": "L-threonine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THRabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "thr__L_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "thr__L_c": 1.0, "pi_c": 1.0}, "id": "THRabcpp", "gene_reaction_rule": "ECS88_3851 and ECS88_3852 and ECS88_3854 and ECS88_3857 and ECS88_3853"}, {"subsystem": "Transport, Inner Membrane", "name": "L-threonine efflux transport via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THRt2pp"]}, "metabolites": {"thr__L_p": 1.0, "thr__L_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "THRt2pp", "gene_reaction_rule": "ECS88_0831 or ECS88_4251"}, {"subsystem": "Transport, Inner Membrane", "name": "L-threonine reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["THRt2rpp"]}, "metabolites": {"thr__L_p": -1.0, "thr__L_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "THRt2rpp", "gene_reaction_rule": "ECS88_3509"}, {"subsystem": "Transport, Inner Membrane", "name": "L-threonine  via sodium symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THRt4pp"]}, "metabolites": {"na1_p": -1.0, "thr__L_p": -1.0, "thr__L_c": 1.0, "na1_c": 1.0}, "id": "THRt4pp", "gene_reaction_rule": "ECS88_3485"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-threonine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["THRtex"]}, "metabolites": {"thr__L_p": 1.0, "thr__L_e": -1.0}, "id": "THRtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "Thymine transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THYMt3pp"]}, "metabolites": {"h_p": -1.0, "h_c": 1.0, "thym_c": -1.0, "thym_p": 1.0}, "id": "THYMt3pp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Thymine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["THYMtex"]}, "metabolites": {"thym_e": -1.0, "thym_p": 1.0}, "id": "THYMtex", "gene_reaction_rule": "ECS88_0957 or ECS88_1492 or ECS88_2364 or ECS88_0276"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Thiazole phosphate synthesis", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THZPSN3"]}, "metabolites": {"h2o_c": 2.0, "nadp_c": 1.0, "nadph_c": -1.0, "iscssh_c": -1.0, "atp_c": -1.0, "4mpetz_c": 1.0, "ppi_c": 1.0, "dhgly_c": -1.0, "iscs_c": 1.0, "dxyl5p_c": -1.0, "amp_c": 1.0, "co2_c": 1.0, "h_c": -1.0}, "id": "THZPSN3", "gene_reaction_rule": "ECS88_2706 and ECS88_4453 and ECS88_4450 and ECS88_0419 and ECS88_4452"}, {"subsystem": "Pentose Phosphate Pathway", "name": "Transketolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TKT1"]}, "metabolites": {"r5p_c": -1.0, "xu5p__D_c": -1.0, "g3p_c": 1.0, "s7p_c": 1.0}, "id": "TKT1", "gene_reaction_rule": "ECS88_2644"}, {"subsystem": "Pentose Phosphate Pathway", "name": "Transketolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TKT2"]}, "metabolites": {"e4p_c": -1.0, "xu5p__D_c": -1.0, "g3p_c": 1.0, "f6p_c": 1.0}, "id": "TKT2", "gene_reaction_rule": "ECS88_2644"}, {"subsystem": "Oxidative Phosphorylation", "name": "Trimethylamine N-oxide reductase (menaquinol 8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TMAOR1"]}, "metabolites": {"h2o_c": 1.0, "mqn8_c": 1.0, "h_c": -1.0, "tmao_c": -1.0, "tma_c": 1.0, "mql8_c": -1.0}, "id": "TMAOR1", "gene_reaction_rule": "ECS88_1632 and ECS88_1633 and ECS88_1634 and ECS88_1635"}, {"subsystem": "Oxidative Phosphorylation", "name": "Trimethylamine N-oxide reductase (menaquinol 8) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TMAOR1pp"]}, "metabolites": {"mqn8_c": 1.0, "h_p": -1.0, "tmao_p": -1.0, "tma_p": 1.0, "h2o_p": 1.0, "mql8_c": -1.0}, "id": "TMAOR1pp", "gene_reaction_rule": "ECS88_1011 and ECS88_1012"}, {"subsystem": "Oxidative Phosphorylation", "name": "Trimethylamine N-oxide reductase (demethylmenaquinol 8) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TMAOR2pp"]}, "metabolites": {"2dmmq8_c": 1.0, "h_p": -1.0, "tmao_p": -1.0, "tma_p": 1.0, "h2o_p": 1.0, "2dmmql8_c": -1.0}, "id": "TMAOR2pp", "gene_reaction_rule": "ECS88_1011 and ECS88_1012"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Trimethylamine N-oxide transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TMAOtex"]}, "metabolites": {"tmao_p": 1.0, "tmao_e": -1.0}, "id": "TMAOtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Trimethylamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TMAtex"]}, "metabolites": {"tma_e": -1.0, "tma_p": 1.0}, "id": "TMAtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Thymidine kinase (ATP:thymidine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TMDK1"]}, "metabolites": {"thymd_c": -1.0, "dtmp_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "TMDK1", "gene_reaction_rule": "ECS88_1306"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Thymidine phosphorylase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TMDPP"]}, "metabolites": {"2dr1p_c": 1.0, "pi_c": -1.0, "thym_c": 1.0, "thymd_c": -1.0}, "id": "TMDPP", "gene_reaction_rule": "ECS88_5063"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Thymidylate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TMDS"]}, "metabolites": {"dump_c": -1.0, "dtmp_c": 1.0, "dhf_c": 1.0, "mlthf_c": -1.0}, "id": "TMDS", "gene_reaction_rule": "ECS88_3122"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Thiamine kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TMK"]}, "metabolites": {"thm_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "thmmp_c": 1.0}, "id": "TMK", "gene_reaction_rule": "ECS88_1120"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Thiamine-phosphate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TMPK"]}, "metabolites": {"thmpp_c": 1.0, "atp_c": -1.0, "adp_c": 1.0, "thmmp_c": -1.0}, "id": "TMPK", "gene_reaction_rule": "ECS88_0412"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Thiamine-phosphate diphosphorylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TMPPP"]}, "metabolites": {"4mpetz_c": -1.0, "ppi_c": 1.0, "h_c": -1.0, "2mahmp_c": -1.0, "thmmp_c": 1.0}, "id": "TMPPP", "gene_reaction_rule": "ECS88_4454"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Triose-phosphate isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TPI"]}, "metabolites": {"dhap_c": -1.0, "g3p_c": 1.0}, "id": "TPI", "gene_reaction_rule": "ECS88_4369"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Triphosphoribosyl-dephospho-CoA synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TPRDCOAS"]}, "metabolites": {"2tpr3dpcoa_c": 1.0, "dpcoa_c": -1.0, "ade_c": 1.0, "atp_c": -1.0}, "id": "TPRDCOAS", "gene_reaction_rule": "ECS88_0654"}, {"subsystem": "Oxidative Phosphorylation", "name": "Thioredoxin reductase (NADPH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRDR"]}, "metabolites": {"trdox_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "trdrd_c": 1.0, "h_c": -1.0}, "id": "TRDR", "gene_reaction_rule": "(ECS88_4203 and ECS88_0917) or (ECS88_0917 and ECS88_2757)"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Trehalose-6-phosphate hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRE6PH"]}, "metabolites": {"tre6p_c": -1.0, "glc__D_c": 1.0, "g6p_c": 1.0, "h2o_c": -1.0}, "id": "TRE6PH", "gene_reaction_rule": "ECS88_4829"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Trehalose-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRE6PP"]}, "metabolites": {"tre6p_c": -1.0, "tre_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0}, "id": "TRE6PP", "gene_reaction_rule": "ECS88_1952"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Alpha,alpha-trehalose-phosphate synthase (UDP-forming)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRE6PS"]}, "metabolites": {"tre6p_c": 1.0, "udp_c": 1.0, "g6p_c": -1.0, "udpg_c": -1.0, "h_c": 1.0}, "id": "TRE6PS", "gene_reaction_rule": "ECS88_1951"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Alpha,alpha-trehalase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TREH"]}, "metabolites": {"tre_c": -1.0, "glc__D_c": 2.0, "h2o_c": -1.0}, "id": "TREH", "gene_reaction_rule": "ECS88_3932"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Alpha,alpha-trehalase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TREHpp"]}, "metabolites": {"h2o_p": -1.0, "tre_p": -1.0, "glc__D_p": 2.0}, "id": "TREHpp", "gene_reaction_rule": "ECS88_1265"}, {"subsystem": "Transport, Inner Membrane", "name": "Trehalose transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TREptspp"]}, "metabolites": {"tre6p_c": 1.0, "pep_c": -1.0, "pyr_c": 1.0, "tre_p": -1.0}, "id": "TREptspp", "gene_reaction_rule": "ECS88_2607 and ECS88_2605 and ECS88_2606 and ECS88_4830"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Trehalose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TREtex"]}, "metabolites": {"tre_p": 1.0, "tre_e": -1.0}, "id": "TREtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Tryptophanase (L-tryptophan)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TRPAS2"]}, "metabolites": {"h2o_c": -1.0, "pyr_c": 1.0, "indole_c": 1.0, "trp__L_c": -1.0, "nh4_c": 1.0}, "id": "TRPAS2", "gene_reaction_rule": "ECS88_4131"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Tryptophan synthase (indoleglycerol phosphate)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRPS1"]}, "metabolites": {"h2o_c": 1.0, "ser__L_c": -1.0, "g3p_c": 1.0, "trp__L_c": 1.0, "3ig3p_c": -1.0}, "id": "TRPS1", "gene_reaction_rule": "ECS88_1395 and ECS88_1396"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Tryptophan synthase (indole)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRPS2"]}, "metabolites": {"h2o_c": 1.0, "ser__L_c": -1.0, "indole_c": -1.0, "trp__L_c": 1.0}, "id": "TRPS2", "gene_reaction_rule": "ECS88_1395 and ECS88_1396"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Tryptophan synthase (indoleglycerol phosphate)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": 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{"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Tyrosine lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TYRL"]}, "metabolites": {"nadp_c": 1.0, "nadph_c": -1.0, "dad_5_c": 1.0, "dhgly_c": 1.0, "h_c": 1.0, "met__L_c": 1.0, "tyr__L_c": -1.0, "4crsol_c": 1.0, "amet_c": -1.0}, "id": "TYRL", "gene_reaction_rule": "ECS88_4451"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Phospho-L-tyrosine phosphatase (periplasmic)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TYRPpp"]}, "metabolites": {"tyrp_p": -1.0, "pi_p": 1.0, "tyr__L_p": 1.0, "h2o_p": -1.0}, "id": "TYRPpp", "gene_reaction_rule": "ECS88_4544"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Phopho-L-tyrosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TYRPtex"]}, "metabolites": {"tyrp_p": 1.0, "tyrp_e": -1.0}, 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{"subsystem": "Alternate Carbon Metabolism", "name": "UDPglucose--hexose-1-phosphate uridylyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UGLT"]}, "metabolites": {"udpgal_c": 1.0, "udpg_c": -1.0, "gal1p_c": -1.0, "g1p_c": 1.0}, "id": "UGLT", "gene_reaction_rule": "ECS88_0774"}, {"subsystem": "Nitrogen Metabolism", "name": "Ureidoglycolate hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UGLYCH"]}, "metabolites": {"urdglyc_c": -1.0, "h2o_c": -1.0, "glx_c": 1.0, "h_c": -2.0, "co2_c": 1.0, "nh4_c": 2.0}, "id": "UGLYCH", "gene_reaction_rule": "ECS88_0504"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UGMDDS"]}, "metabolites": {"atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "ugmda_c": 1.0, "pi_c": 1.0, "alaala_c": -1.0, "ugmd_c": -1.0}, "id": "UGMDDS", "gene_reaction_rule": "ECS88_0089"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "UDP-3-O-acetylglucosamine deacetylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UHGADA"]}, "metabolites": {"u3aga_c": -1.0, "u3hga_c": 1.0, "ac_c": 1.0, "h2o_c": -1.0}, "id": "UHGADA", "gene_reaction_rule": "ECS88_0100"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "UDP-L-Ara4N formyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ULA4NFT"]}, "metabolites": {"h_c": 1.0, "udpLa4fn_c": 1.0, "udpLa4n_c": -1.0, "thf_c": 1.0, "10fthf_c": -1.0}, "id": "ULA4NFT", "gene_reaction_rule": "ECS88_2404"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Transport (cytoplasm to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ULA4Ntppi"]}, "metabolites": {"uLa4n_p": 1.0, "uLa4n_c": -1.0}, "id": "ULA4Ntppi", "gene_reaction_rule": "ECS88_2408 and ECS88_2409"}, {"subsystem": "Murein Recycling", "name": "UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UM3PL"]}, "metabolites": {"LalaDgluMdap_c": -1.0, "atp_c": -1.0, "uamr_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "ugmd_c": 1.0}, "id": "UM3PL", "gene_reaction_rule": "ECS88_4823"}, {"subsystem": "Murein Recycling", "name": "UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate-D-alanine L,D-carboxypeptidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UM4PCP"]}, "metabolites": {"h2o_c": -1.0, "ala__D_c": 1.0, "um4p_c": -1.0, "ugmd_c": 1.0}, "id": "UM4PCP", "gene_reaction_rule": "ECS88_1255"}, {"subsystem": "Murein Recycling", "name": "UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate-D-alanine ligase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UM4PL"]}, "metabolites": {"LalaDgluMdapDala_c": -1.0, "atp_c": -1.0, "uamr_c": -1.0, "um4p_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "UM4PL", "gene_reaction_rule": "ECS88_4823"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "UMP kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UMPK"]}, "metabolites": {"ump_c": -1.0, "udp_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "UMPK", "gene_reaction_rule": "ECS88_0938 or ECS88_0181"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "UMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UMPtex"]}, "metabolites": {"ump_p": 1.0, "ump_e": -1.0}, "id": "UMPtex", "gene_reaction_rule": "ECS88_0957 or ECS88_1492 or ECS88_2364 or ECS88_0276"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Undecaprenyl phosphate-L-Ara4FN formylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UPLA4FNF"]}, "metabolites": {"h2o_c": -1.0, "for_c": 1.0, "uLa4fn_c": -1.0, "uLa4n_c": 1.0}, "id": "UPLA4FNF", "gene_reaction_rule": "ECS88_2405"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Undecaprenyl phosphate-L-Ara4FN transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UPLA4FNT"]}, "metabolites": {"udpLa4fn_c": -1.0, "udp_c": 1.0, "uLa4fn_c": 1.0, "udcpp_c": -1.0}, "id": "UPLA4FNT", "gene_reaction_rule": "ECS88_2403"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Uroporphyrinogen methyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UPP3MT"]}, "metabolites": {"amet_c": -2.0, "dscl_c": 1.0, "ahcys_c": 2.0, "h_c": 1.0, "uppg3_c": -1.0}, "id": "UPP3MT", "gene_reaction_rule": "ECS88_4225 or ECS88_3759"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Uroporphyrinogen-III synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UPP3S"]}, "metabolites": {"h2o_c": 1.0, "hmbil_c": -1.0, "uppg3_c": 1.0}, "id": "UPP3S", "gene_reaction_rule": "ECS88_4226"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Uroporphyrinogen decarboxylase (uroporphyrinogen III)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UPPDC1"]}, "metabolites": {"co2_c": 4.0, "h_c": -4.0, "uppg3_c": -1.0, "cpppg3_c": 1.0}, "id": "UPPDC1", "gene_reaction_rule": "ECS88_4458"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Uracil phosphoribosyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UPPRT"]}, "metabolites": {"ump_c": 1.0, "ppi_c": 1.0, "prpp_c": -1.0, "ura_c": -1.0}, "id": "UPPRT", "gene_reaction_rule": "ECS88_2669"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Peroxyureidoacrylate hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["URACPAH"]}, "metabolites": {"h2o_c": -1.0, "poaac_c": 1.0, "h_c": 1.0, "uracp_c": -1.0, "cbm_c": 1.0}, "id": "URACPAH", "gene_reaction_rule": "ECS88_1027"}, {"subsystem": "Transport, Inner Membrane", "name": "Uracil transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["URAt2pp"]}, "metabolites": {"ura_c": 1.0, "ura_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "URAt2pp", "gene_reaction_rule": "ECS88_2668"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Uracil transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["URAtex"]}, "metabolites": {"ura_p": 1.0, "ura_e": -1.0}, "id": "URAtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Ureidoglycolate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["URDGLYCD"]}, "metabolites": {"urdglyc_c": -1.0, "nadh_c": 1.0, "oxur_c": 1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "URDGLYCD", "gene_reaction_rule": "ECS88_0516"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Urea transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UREAtex"]}, "metabolites": {"urea_p": 1.0, "urea_e": -1.0}, "id": "UREAtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "Urea transport via facilitate diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UREAtpp"]}, "metabolites": {"urea_p": -1.0, "urea_c": 1.0}, "id": "UREAtpp", "gene_reaction_rule": "ECS88_4377"}, {"subsystem": "Unassigned", "name": "Uricase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["URIC"]}, "metabolites": {"o2_c": -1.0, "h2o_c": -2.0, "urate_c": -1.0, "h2o2_c": 1.0, "co2_c": 1.0, "alltn_c": 1.0}, "id": "URIC", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Uridine hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["URIH"]}, "metabolites": {"uri_c": -1.0, "h2o_c": -1.0, "rib__D_c": 1.0, "ura_c": 1.0}, "id": "URIH", "gene_reaction_rule": "ECS88_2310 or ECS88_0686 or ECS88_0029"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Uridine kinase (GTP:Uridine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["URIK2"]}, "metabolites": {"uri_c": -1.0, "gtp_c": -1.0, "gdp_c": 1.0, "h_c": 1.0, "ump_c": 1.0}, "id": "URIK2", "gene_reaction_rule": "ECS88_2165"}, {"subsystem": "Transport, Inner Membrane", "name": "Uridine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["URIt2pp", "URIt2rpp"]}, "metabolites": {"uri_c": 1.0, "uri_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "URIt2pp_copy1", "gene_reaction_rule": "ECS88_2587 or ECS88_3247"}, {"subsystem": "Transport, Inner Membrane", "name": "Uridine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["URIt2pp", "URIt2rpp"]}, "metabolites": {"uri_c": 1.0, "uri_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "URIt2pp_copy2", "gene_reaction_rule": "ECS88_2595"}, {"subsystem": "Transport, Outer Membrane", "name": "Uridine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["URItex"]}, "metabolites": {"uri_p": 1.0, "uri_e": -1.0}, "id": "URItex", "gene_reaction_rule": "ECS88_0406"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "UDP-sugar hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["USHD"]}, "metabolites": {"u23ga_c": -1.0, "h2o_c": -1.0, "h_c": 2.0, "lipidX_c": 1.0, "ump_c": 1.0}, "id": "USHD", "gene_reaction_rule": "ECS88_0524"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Valine transaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["VALTA"]}, "metabolites": {"akg_c": -1.0, "glu__L_c": 1.0, "3mob_c": 1.0, "val__L_c": -1.0}, "id": "VALTA", "gene_reaction_rule": "ECS88_4193"}, {"subsystem": "tRNA Charging", "name": "Valyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["VALTRS"]}, "metabolites": {"valtrna_c": 1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "trnaval_c": -1.0, "val__L_c": -1.0}, "id": "VALTRS", "gene_reaction_rule": "ECS88_4845"}, {"subsystem": "Transport, Inner Membrane", "name": "L-valine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["VALabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "val__L_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "val__L_c": 1.0}, "id": "VALabcpp", "gene_reaction_rule": "ECS88_3851 and ECS88_3852 and ECS88_3854 and ECS88_3857 and ECS88_3853"}, {"subsystem": "Transport, Inner Membrane", "name": "L-valine reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["VALt2rpp"]}, "metabolites": {"val__L_p": -1.0, "h_c": 1.0, "h_p": -1.0, "val__L_c": 1.0}, "id": "VALt2rpp", "gene_reaction_rule": "ECS88_0396 or (ECS88_2948 and ECS88_2947)"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-valine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["VALtex"]}, "metabolites": {"val__L_e": -1.0, "val__L_p": 1.0}, "id": "VALtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Valine-pyruvate aminotransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["VPAMTr", "VPAMT"]}, "metabolites": {"pyr_c": 1.0, "val__L_c": 1.0, "ala__L_c": -1.0, "3mob_c": -1.0}, "id": "VPAMTr_copy1", "gene_reaction_rule": "ECS88_3991"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Tungsten pterin cofactor synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["WCOS"]}, "metabolites": {"cu2_c": 1.0, "h2o_c": 1.0, "tungs_c": -1.0, "h_c": -2.0, "mptamp_c": -1.0, "wco_c": 1.0, "amp_c": 1.0}, "id": "WCOS", "gene_reaction_rule": "ECS88_0844"}, {"subsystem": "Alternate Carbon Metabolism", "name": "L-xylulose 5-phosphate 3-epimerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["X5PL3E"]}, "metabolites": {"xu5p__L_c": -1.0, "ru5p__L_c": 1.0}, "id": "X5PL3E", "gene_reaction_rule": "ECS88_4783"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Xanthine dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["XAND"]}, "metabolites": {"h2o_c": -1.0, "xan_c": -1.0, "urate_c": 1.0, "h_c": 1.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "XAND", "gene_reaction_rule": "ECS88_3145 and ECS88_3146 and ECS88_3147"}, {"subsystem": "Transport, Inner Membrane", "name": "Xanthine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["XANt2pp"]}, "metabolites": {"xan_c": 1.0, "xan_p": -1.0, "h_p": -1.0, "h_c": 1.0}, "id": "XANt2pp", "gene_reaction_rule": "ECS88_4070 or ECS88_3161"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Xanthine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XANtex"]}, "metabolites": {"xan_e": -1.0, "xan_p": 1.0}, "id": "XANtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "Xanthine reversible transport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XANtpp"]}, "metabolites": {"xan_p": -1.0, "xan_c": 1.0}, "id": "XANtpp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "XMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XMPtex"]}, "metabolites": {"xmp_p": 1.0, "xmp_e": -1.0}, "id": "XMPtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Xanthine phosphoribosyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["XPPT"]}, "metabolites": {"xmp_c": 1.0, "ppi_c": 1.0, "prpp_c": -1.0, "xan_c": -1.0}, "id": "XPPT", "gene_reaction_rule": "ECS88_0273"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Xanthosine hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["XTSNH"]}, "metabolites": {"h2o_c": -1.0, "rib__D_c": 1.0, "xan_c": 1.0, "xtsn_c": -1.0}, "id": "XTSNH", "gene_reaction_rule": "ECS88_0029"}, {"subsystem": "Transport, Inner Membrane", "name": "Xanthosine transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XTSNt2rpp"]}, "metabolites": {"xtsn_p": -1.0, "h_c": 1.0, "h_p": -1.0, "xtsn_c": 1.0}, "id": "XTSNt2rpp", "gene_reaction_rule": "ECS88_2595"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Xanthosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XTSNtex"]}, "metabolites": {"xtsn_e": -1.0, "xtsn_p": 1.0}, "id": "XTSNtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Xylose isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XYLI1"]}, "metabolites": {"xylu__D_c": 1.0, "xyl__D_c": -1.0}, "id": "XYLI1", "gene_reaction_rule": "ECS88_3983"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Xylose isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XYLI2"]}, "metabolites": {"glc__D_c": -1.0, "fru_c": 1.0}, "id": "XYLI2", "gene_reaction_rule": "ECS88_3983"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Xylulokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["XYLK"]}, "metabolites": {"xylu__D_c": -1.0, "xu5p__D_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "XYLK", "gene_reaction_rule": "ECS88_0066 or ECS88_3982"}, {"subsystem": "Alternate Carbon Metabolism", "name": "L-xylulokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["XYLK2"]}, "metabolites": {"xylu__L_c": -1.0, "xu5p__L_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "XYLK2", "gene_reaction_rule": "ECS88_0066 or ECS88_4000"}, {"subsystem": "Transport, Inner Membrane", "name": "L-xylulose transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["XYLUt2pp"]}, "metabolites": {"xylu__L_c": 1.0, "xylu__L_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "XYLUt2pp", "gene_reaction_rule": "ECS88_3997 and ECS88_3998 and ECS88_3999"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-xylulose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XYLUtex"]}, "metabolites": {"xylu__L_p": 1.0, "xylu__L_e": -1.0}, "id": "XYLUtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport, Inner Membrane", "name": "D-xylose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["XYLabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "xyl__D_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "xyl__D_c": 1.0}, "id": "XYLabcpp", "gene_reaction_rule": "ECS88_3984 and ECS88_3985 and ECS88_3986"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-xylose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XYLtex"]}, "metabolites": {"xyl__D_e": -1.0, "xyl__D_p": 1.0}, "id": "XYLtex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Zinc (Zn+2) ABC transporter, efflux (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ZN2abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "zn2_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "zn2_c": -1.0}, "id": "ZN2abcpp", "gene_reaction_rule": "ECS88_3872"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Zinc (Zn+2) transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ZN2t3pp"]}, "metabolites": {"h_p": -1.0, "zn2_c": -1.0, "zn2_p": 1.0, "h_c": 1.0}, "id": "ZN2t3pp", "gene_reaction_rule": "ECS88_4365 or ECS88_0768"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Zinc transport in via permease (no H+)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ZN2tpp"]}, "metabolites": {"zn2_c": 1.0, "zn2_p": -1.0}, "id": "ZN2tpp", "gene_reaction_rule": "ECS88_3437"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Zinc (Zn+2) transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ZNabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "zn2_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "zn2_c": 1.0}, "id": "ZNabcpp", "gene_reaction_rule": "ECS88_1914 and ECS88_1916 and ECS88_1915"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Zinc (Zn+2) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["Zn2tex"]}, "metabolites": {"zn2_e": -1.0, "zn2_p": 1.0}, "id": "Zn2tex", "gene_reaction_rule": "ECS88_0276 or ECS88_0957 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Deoxyribose transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DRIBtex"]}, "metabolites": {"drib_e": -1.0, "drib_p": 1.0}, "id": "DRIBtex", "gene_reaction_rule": "ECS88_0276 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Exchange", "name": "4 hydroxyphenylacetate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_4hphac_LPAREN_e_RPAREN_", "EX_4hpa_LPAREN_e_RPAREN_"]}, "metabolites": {"4hphac_e": -1.0}, "id": "EX_4hphac_e_copy1", "gene_reaction_rule": ""}, {"subsystem": "Transport Inner Membrane", "name": "Tartrate facilitated transport periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TARTRtpp"]}, "metabolites": {"tartr__L_p": -1.0, "tartr__L_c": 1.0}, "id": "TARTRtpp", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "4 Aminobenzoate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_4abz_LPAREN_e_RPAREN_"]}, "metabolites": {"4abz_e": -1.0}, "id": "EX_4abz_e", "gene_reaction_rule": ""}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxooctanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HACD3i"]}, "metabolites": {"nad_c": -1.0, "nadh_c": 1.0, "h_c": 1.0, "3oocoa_c": 1.0, "3hocoa_c": -1.0}, "id": "HACD3i", "gene_reaction_rule": "ECS88_2488 or ECS88_4294"}, {"subsystem": "Transport Inner Membrane", "name": "Phosphoenolpyruvate phosphate antiporter periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PEPt6pp"]}, "metabolites": {"pep_c": 1.0, "pi_p": 1.0, "pep_p": -1.0, "pi_c": -1.0}, "id": "PEPt6pp", "gene_reaction_rule": "ECS88_3277"}, {"subsystem": "Transport Outer Membrane Porin", "name": "3 Phospho D glycerate transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["3PGtex"]}, "metabolites": {"3pg_e": -1.0, "3pg_p": 1.0}, "id": "3PGtex", "gene_reaction_rule": "ECS88_0276 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport", "name": "Octadecenoate transport via proton symport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OCDCEAt2pp"]}, "metabolites": {"ocdcea_c": 1.0, "ocdcea_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "OCDCEAt2pp", "gene_reaction_rule": "ECS88_2492"}, {"subsystem": "Exchange", "name": "Cisaconitate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_acon_C_LPAREN_e_RPAREN_"]}, "metabolites": {"acon_C_e": -1.0}, "id": "EX_acon_C_e", "gene_reaction_rule": ""}, {"subsystem": "Transport", "name": "Glycine betaine transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYBt2pp", "GLYBt6pp"]}, "metabolites": {"glyb_c": 1.0, "h_c": 1.0, "h_p": -1.0, "glyb_p": -1.0}, "id": "GLYBt2pp_copy2", "gene_reaction_rule": "ECS88_4612"}, {"subsystem": "Arginine and Proline Metabolism", "name": "2-keto-4-methylthiobutyrate transamination", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UNK3"]}, "metabolites": {"akg_c": 1.0, "glu__L_c": -1.0, "2kmb_c": -1.0, "met__L_c": 1.0}, "id": "UNK3", "gene_reaction_rule": "ECS88_4533"}, {"subsystem": "Transport", "name": "Hexadecanoate transport via proton symport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HDCAt2pp"]}, "metabolites": {"hdca_c": 1.0, "h_c": 1.0, "h_p": -1.0, "hdca_p": -1.0}, "id": "HDCAt2pp", "gene_reaction_rule": "ECS88_2491"}, {"subsystem": "Exchange", "name": "Chitobiose exchange", "upper_bound": 0.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_chitob_LPAREN_e_RPAREN_"]}, "metabolites": {"chitob_e": -1.0}, "id": "EX_chitob_e", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Glycosyl transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ENTERGLCT1"]}, "metabolites": {"udp_c": 1.0, "enter_c": -1.0, "udpg_c": -1.0, "h_c": 1.0, "entermg_c": 1.0}, "id": "ENTERGLCT1", "gene_reaction_rule": "iroB"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Glycosyl transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ENTERGLCT2"]}, "metabolites": {"udp_c": 1.0, "salchs4_c": 1.0, "udpg_c": -1.0, "h_c": 1.0, "entermg_c": -1.0}, "id": "ENTERGLCT2", "gene_reaction_rule": "iroB"}, {"subsystem": "Alternate Carbon Metabolism", "name": "D Tagatose 1 phosphate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TAG1PK"]}, "metabolites": {"adp_c": 1.0, "tag1p__D_c": -1.0, "h_c": 1.0, "tagdp__D_c": 1.0, "atp_c": -1.0}, "id": "TAG1PK", "gene_reaction_rule": "ECS88_1775"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxohexanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HACD2i"]}, "metabolites": {"3hhcoa_c": -1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0, "3ohcoa_c": 1.0}, "id": "HACD2i", "gene_reaction_rule": "ECS88_4294 or ECS88_2488"}, {"subsystem": "Exchange", "name": "Ferrioxamine B exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_feroxB_LPAREN_e_RPAREN_"]}, "metabolites": {"feroxB_e": -1.0}, "id": "EX_feroxB_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "Tricarballylate Exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_tcb_LPAREN_e_RPAREN_"]}, "metabolites": {"tcb_e": -1.0}, "id": "EX_tcb_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "Trithionate Exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_tton_LPAREN_e_RPAREN_"]}, "metabolites": {"tton_e": -1.0}, "id": "EX_tton_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "4-Hydroxy-L-threonine Exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_4hthr_LPAREN_e_RPAREN_"]}, "metabolites": {"4hthr_e": -1.0}, "id": "EX_4hthr_e", "gene_reaction_rule": ""}, {"subsystem": "Transport", "name": "1-deoxy-d-xyluose transport", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DXYLUDtex"]}, "metabolites": {"dxyl_e": -1.0, "dxyl_p": 1.0}, "id": "DXYLUDtex", "gene_reaction_rule": "ECS88_0276 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport", "name": "Chitobiose transport via PTS", "upper_bound": 0.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHITOBpts"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "chitob_p": -1.0, "chit6p_c": 1.0}, "id": "CHITOBpts", "gene_reaction_rule": "ECS88_1788 and ECS88_1790 and ECS88_1789 and ECS88_2605 and ECS88_2606"}, {"subsystem": "Exchange", "name": "Ferrioxamine E fe exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_feroxEfe_LPAREN_e_RPAREN_"]}, "metabolites": {"feroxEfe_e": -1.0}, "id": "EX_feroxEfe_e", "gene_reaction_rule": ""}, {"subsystem": "Transport Inner Membrane", "name": "Aminoimidazole riboside facilitated transport periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AIRStpp"]}, "metabolites": {"airs_p": -1.0, "airs_c": 1.0}, "id": "AIRStpp", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "Ferrioxamine E exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_feroxE_LPAREN_e_RPAREN_"]}, "metabolites": {"feroxE_e": -1.0}, "id": "EX_feroxE_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "O-acetyl-L-serine sulfhydrylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SLCYSS"]}, "metabolites": {"ac_c": 1.0, "acser_c": -1.0, "tsul_c": -1.0, "slcys_c": 1.0}, "id": "SLCYSS", "gene_reaction_rule": "ECS88_2610"}, {"subsystem": "Exchange", "name": "Phosphoenolpyruvate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_pep_LPAREN_e_RPAREN_"]}, "metabolites": {"pep_e": -1.0}, "id": "EX_pep_e", "gene_reaction_rule": ""}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxododecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HACD5i"]}, "metabolites": {"3oddcoa_c": 1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0, "3hddcoa_c": -1.0}, "id": "HACD5i", "gene_reaction_rule": "ECS88_4294 or ECS88_2488"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Salmochelin SX via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SALCHSXtex"]}, "metabolites": {"salchsx_p": 1.0, "salchsx_e": -1.0}, "id": "SALCHSXtex", "gene_reaction_rule": "ECS88_0276 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Exchange", "name": "2-3-dihydroxybenzoylserine trimer Exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_23dhbzs3_LPAREN_e_RPAREN_"]}, "metabolites": {"23dhbzs3_e": -1.0}, "id": "EX_23dhbzs3_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "Tetrathionate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_tet_LPAREN_e_RPAREN_"]}, "metabolites": {"tet_e": -1.0}, "id": "EX_tet_e", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane", "name": "Salmochelin S4 Fe III transport via ton system extracellular ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SALCHS4FEtonex"]}, "metabolites": {"salchs4fe_e": -1.0, "salchs4fe_p": 1.0, "h_p": -1.0, "h_c": 1.0}, "id": "SALCHS4FEtonex", "gene_reaction_rule": "ECS88_2303 and ECS88_1322 and ECS88_3386 and ECS88_3387"}, {"subsystem": "Extracellular exchange", "name": "Salmochelin S4 exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_SALCHS4_LPAREN_e_RPAREN_"]}, "metabolites": {"salchs4_e": -1.0}, "id": "EX_salchs4_e", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Salmochelin S4 Fe III transport via ABC system periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SALCHS4FEabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "salchs4fe_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "salchs4fe_p": -1.0}, "id": "SALCHS4FEabcpp", "gene_reaction_rule": "ECS88_0631 and ECS88_0627 and ECS88_0629 and ECS88_0628"}, {"subsystem": "Transport", "name": "Nicotinamide riboside transport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RNAMtpp"]}, "metabolites": {"rnam_p": -1.0, "rnam_c": 1.0}, "id": "RNAMtpp", "gene_reaction_rule": "ECS88_0767"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Chitobiose-6-phosphate hydrolase", "upper_bound": 0.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHITPH"]}, "metabolites": {"acgam_c": 1.0, "h2o_c": -1.0, "acgam6p_c": 1.0, "chit6p_c": -1.0}, "id": "CHITPH", "gene_reaction_rule": "ECS88_1786"}, {"subsystem": "Transport Inner Membrane", "name": "D Glycerate 2 phosphate phosphate antiporter periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2PGt6pp"]}, "metabolites": {"pi_p": 1.0, "pi_c": -1.0, "2pg_p": -1.0, "2pg_c": 1.0}, "id": "2PGt6pp", "gene_reaction_rule": "ECS88_3277"}, {"subsystem": "Transport Inner Membrane", "name": "L cystine uptake via ABC system periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYSIabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "cysi__L_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "cysi__L_p": -1.0, "pi_c": 1.0}, "id": "CYSIabcpp", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "D Tagatose exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_tag_D_LPAREN_e_RPAREN_"]}, "metabolites": {"tag__D_e": -1.0}, "id": "EX_tag__D_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "Oxaloacetate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_oaa_LPAREN_e_RPAREN_"]}, "metabolites": {"oaa_e": -1.0}, "id": "EX_oaa_e", "gene_reaction_rule": ""}, {"subsystem": "Transport", "name": "Octadecanoate transport via proton symport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OCDCAt2pp"]}, "metabolites": {"ocdca_p": -1.0, "h_c": 1.0, "h_p": -1.0, "ocdca_c": 1.0}, "id": "OCDCAt2pp", "gene_reaction_rule": "ECS88_2492"}, {"subsystem": "Exchange", 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"id": "ICITtex", "gene_reaction_rule": "ECS88_0276 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport", "name": "Tetradecanoate transport via proton symport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TTDCAt2pp"]}, "metabolites": {"h_p": -1.0, "h_c": 1.0, "ttdca_p": -1.0, "ttdca_c": 1.0}, "id": "TTDCAt2pp", "gene_reaction_rule": "ECS88_2494"}, {"subsystem": "Exchange", "name": "2-3-dihydroxybenzoylserine trimer-Fe-III Exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_fe3dhbzs3_LPAREN_e_RPAREN_"]}, "metabolites": {"fe3dhbzs3_e": -1.0}, "id": "EX_fe3dhbzs3_e", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Naphthoate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NPHS"]}, "metabolites": {"sbzcoa_c": -1.0, "dhna_c": 1.0, "coa_c": 1.0}, "id": "NPHS", "gene_reaction_rule": "ECS88_2413"}, {"subsystem": "Transport", "name": "Dodecanoate transport via proton symport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DDCAt2pp"]}, "metabolites": {"ddca_c": 1.0, "ddca_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "DDCAt2pp", "gene_reaction_rule": "ECS88_2494"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Salmochelin s2 Fe III sequestration", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SALCHS2FEexs"]}, "metabolites": {"salchs2fe_e": 1.0, "salchs2_e": -1.0, "fe3_e": -1.0}, "id": "SALCHS2FEexs", "gene_reaction_rule": "s0001"}, {"subsystem": "Exchange", "name": "Deoxy D Ribose exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_drib_LPAREN_e_RPAREN_"]}, "metabolites": {"drib_e": -1.0}, "id": "EX_drib_e", "gene_reaction_rule": ""}, {"subsystem": "Transport, Inner Membrane", "name": "4-hydroxy-L-threonine transport", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["4HTHRtrpp"]}, "metabolites": {"4hthr_p": -1.0, "h_c": 1.0, "h_p": -1.0, "4hthr_c": 1.0}, "id": "4HTHRtrpp", "gene_reaction_rule": "ECS88_3509"}, {"subsystem": "Transport", "name": "Myo-inositol transport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["INOSTtpp"]}, "metabolites": {"inost_c": 1.0, "h_c": 1.0, "h_p": -1.0, "inost_p": -1.0}, "id": "INOSTtpp", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "L cystine transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CYSItex"]}, "metabolites": {"cysi__L_p": 1.0, "cysi__L_e": -1.0}, "id": "CYSItex", "gene_reaction_rule": "ECS88_0276 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Exchange", "name": "Ferrioxamine B fe exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_feroxBfe_LPAREN_e_RPAREN_"]}, "metabolites": {"feroxBfe_e": -1.0}, "id": "EX_feroxBfe_e", 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"Extracellular exchange", "name": "Salmochelin SX exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_SALCHSX_LPAREN_e_RPAREN_"]}, "metabolites": {"salchsx_e": -1.0}, "id": "EX_salchsx_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "AEP exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_AEP_LPAREN_e_RPAREN_"]}, "metabolites": {"AEP_e": -1.0}, "id": "EX_AEP_e", "gene_reaction_rule": ""}, {"subsystem": "Transport", "name": "L-leucine transport in via sodium symport", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LEUt4rpp"]}, "metabolites": {"na1_p": -1.0, "leu__L_p": -1.0, "leu__L_c": 1.0, "na1_c": 1.0}, "id": "LEUt4rpp", "gene_reaction_rule": "ECS88_0396"}, {"subsystem": "Exchange", "name": "Isocitrate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_icit_LPAREN_e_RPAREN_"]}, "metabolites": {"icit_e": -1.0}, "id": "EX_icit_e", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "Oxaloacetate transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["OAAtex"]}, "metabolites": {"oaa_e": -1.0, "oaa_p": 1.0}, "id": "OAAtex", "gene_reaction_rule": "ECS88_1492 or ECS88_0276 or ECS88_2364"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "4-Hydroxy-L-threonine kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["4HTHRK"]}, "metabolites": {"adp_c": 1.0, "phthr_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "4hthr_c": -1.0}, "id": "4HTHRK", "gene_reaction_rule": "ECS88_0003"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Tetrathionate transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TETtex"]}, "metabolites": {"tet_p": 1.0, "tet_e": -1.0}, "id": "TETtex", 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{"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Enterobactin hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ENTERH"]}, "metabolites": {"h2o_c": -1.0, "23dhbzs3_c": 1.0, "enter_c": -1.0}, "id": "ENTERH", "gene_reaction_rule": "ECS88_0623"}, {"subsystem": "Exchange", "name": "Residual atoms of reaction DMBZIDSYN exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_remnant1_LPAREN_e_RPAREN_"]}, "metabolites": {"remnant1_e": -1.0}, "id": "EX_remnant1_e", "gene_reaction_rule": ""}, {"subsystem": "Cysteine Metabolism", "name": "S-sulfo-L-cysteine sulfite lyase ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SCYSSL"]}, "metabolites": {"cys__L_c": 1.0, "so3_c": 1.0, "slcys_c": -1.0, "h_c": 1.0, "gthrd_c": -2.0, "gthox_c": 1.0}, "id": "SCYSSL", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "D Tagatose transport via diffusion 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["CTECOAI8", "ODECOAI"]}, "metabolites": {"od2coa_c": 1.0, "odecoa_c": -1.0}, "id": "CTECOAI8_copy2", "gene_reaction_rule": "ECS88_4294"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HACD1i"]}, "metabolites": {"aacoa_c": 1.0, "3hbcoa_c": -1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "HACD1i", "gene_reaction_rule": "ECS88_4294 or ECS88_2488"}, {"subsystem": "Exchange", "name": "N-Ribosylnicotinamide Exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_rnam_LPAREN_e_RPAREN_"]}, "metabolites": {"rnam_e": -1.0}, "id": "EX_rnam_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "Aminoimidazole riboside exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_airs_LPAREN_e_RPAREN_"]}, "metabolites": {"airs_e": -1.0}, "id": "EX_airs_e", "gene_reaction_rule": ""}, 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"EX_feroxGfe_e", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Salmochelin s2 Fe III transport via ABC system periplasm", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SALCHS2FEabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "salchs2fe_p": -1.0, "salchs2fe_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "SALCHS2FEabcpp", "gene_reaction_rule": "ECS88_0631 and ECS88_0627 and ECS88_0629 and ECS88_0628"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-cis-2-trans-enoyl-CoA isomerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CTECOAI6", "TDECOAI"]}, "metabolites": {"tdecoa_c": -1.0, "td2coa_c": 1.0}, "id": "CTECOAI6_copy2", "gene_reaction_rule": "ECS88_4294"}, {"subsystem": "Transport Inner Membrane", "name": "Oxaloacetate transport via proton symport 2 H  periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OAAt2_2pp"]}, "metabolites": {"h_p": -2.0, "h_c": 2.0, "oaa_c": 1.0, "oaa_p": -1.0}, "id": "OAAt2_2pp", "gene_reaction_rule": "ECS88_3942"}, {"subsystem": "Exchange", "name": "Undecaprenyl diphosphate galactose-rhamnose-mannose-abequose-acetyl Exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_udcpo5_LPAREN_e_RPAREN_"]}, "metabolites": {"udcpo5_e": -1.0}, "id": "EX_udcpo5_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "L-gulonate Exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_guln_L_LPAREN_e_RPAREN_"]}, "metabolites": {"guln__L_e": -1.0}, "id": "EX_guln__L_e", "gene_reaction_rule": ""}, {"subsystem": "Pyruvate Metabolism", "name": "Pyruvate flavodoxin oxidoreductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PFOR"]}, "metabolites": {"fldrd_c": 1.0, "pyr_c": -1.0, "coa_c": -1.0, "h_c": -1.0, "accoa_c": 1.0, "fldox_c": -1.0, "co2_c": 1.0}, "id": "PFOR", "gene_reaction_rule": "(ECS88_0721 and ECS88_1493) or (ECS88_3175 and ECS88_1493)"}, {"subsystem": "Transport", "name": "4-hydroxy-L-threonine transport", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["4HTHRtex"]}, "metabolites": {"4hthr_e": -1.0, "4hthr_p": 1.0}, "id": "4HTHRtex", "gene_reaction_rule": "ECS88_0276 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Transport Outer Membrane Porin", "name": "D Glycerate 2 phosphate transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["2PGtex"]}, "metabolites": {"2pg_e": -1.0, "2pg_p": 1.0}, "id": "2PGtex", "gene_reaction_rule": "ECS88_0276 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Exchange", "name": "Ferrioxamine G exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_feroxG_LPAREN_e_RPAREN_"]}, "metabolites": {"feroxG_e": -1.0}, "id": "EX_feroxG_e", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "Formamide transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FOAMtex"]}, "metabolites": {"foam_p": 1.0, "foam_e": -1.0}, "id": "FOAMtex", "gene_reaction_rule": "ECS88_0276 or ECS88_1492 or ECS88_2364"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Thiazole phosphate synthesis", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THZPSN"]}, "metabolites": {"cys__L_c": -1.0, "h2o_c": 1.0, "atp_c": -1.0, "4mpetz_c": 1.0, "ppi_c": 1.0, "ala__L_c": 1.0, "4hba_c": 1.0, "dxyl5p_c": -1.0, "amp_c": 1.0, "tyr__L_c": -1.0, "co2_c": 1.0, "h_c": 1.0}, "id": "THZPSN", "gene_reaction_rule": "ECS88_2706 and ECS88_4453 and (ECS88_4450 and ECS88_4451) and ECS88_0419 and ECS88_4452"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2C-methyl-D-erythritol 2,4 cyclodiphosphate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MECDPDH2"]}, "metabolites": {"2mecdp_c": -1.0, "h2o_c": 1.0, "nadh_c": -1.0, "h2mb4p_c": 1.0, "nad_c": 1.0}, "id": "MECDPDH2", "gene_reaction_rule": "ECS88_2691"}, {"subsystem": "Exchange", "name": "Agmatine/putrescine antiporter (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AGMPTRCtpp"]}, "metabolites": {"agm_p": -1.0, "agm_c": 1.0, "ptrc_p": 1.0, "ptrc_c": -1.0}, "id": "AGMPTRCtpp", "gene_reaction_rule": "ECS88_0613"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylaminoimidazolesuccinocarboxamide synthase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PRASCSi", "PRASCS"]}, "metabolites": {"atp_c": -1.0, "5aizc_c": -1.0, "asp__L_c": -1.0, "25aics_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "PRASCSi_copy2", "gene_reaction_rule": "ECS88_2658"}, {"subsystem": "Glutamate Metabolism", "name": "Glutamate synthase (NADPH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUSy"]}, "metabolites": {"akg_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "glu__L_c": 2.0, "h_c": -1.0, "gln__L_c": -1.0}, "id": "GLUSy", "gene_reaction_rule": "ECS88_3596 and ECS88_3597"}, {"subsystem": "Exchange", "name": "Diacetyl exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_diact_LPAREN_e_RPAREN_"]}, "metabolites": {"diact_e": -1.0}, "id": "EX_diact_e", "gene_reaction_rule": ""}, {"subsystem": "Tryptophan metabolism", "name": "Tryptophan transaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TRPTA"]}, "metabolites": {"akg_c": -1.0, "glu__L_c": 1.0, "indpyr_c": 1.0, "trp__L_c": -1.0}, "id": "TRPTA", "gene_reaction_rule": "ECS88_4533"}, {"subsystem": "Lysine Metabolism", "name": "Piperideine dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPRDNDH"]}, "metabolites": {"pprdn_c": -1.0, "h2o_c": -2.0, "5aptn_c": 1.0, "h_c": 1.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "PPRDNDH", "gene_reaction_rule": "ECS88_3513"}, {"subsystem": "Exchange", "name": "Cellobiose exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_cellb_LPAREN_e_RPAREN_"]}, "metabolites": {"cellb_e": -1.0}, "id": "EX_cellb_e", "gene_reaction_rule": ""}, {"subsystem": "Transport", "name": "Inositol transport in via proton symport", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["INSTt2r"]}, "metabolites": {"inost_e": -1.0, "h_e": -1.0, "inost_c": 1.0, "h_c": 1.0}, "id": "INSTt2", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": " R R  2 3 Butanediol exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_btd_RR_LPAREN_e_RPAREN_"]}, "metabolites": {"btd_RR_e": -1.0}, "id": "EX_btd_RR_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "1,3-Propanediol exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_13ppd_LPAREN_e_RPAREN_"]}, "metabolites": {"13ppd_e": -1.0}, "id": "EX_13ppd_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "Ribitol exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_rbt_LPAREN_e_RPAREN_"]}, "metabolites": {"rbt_e": -1.0}, "id": "EX_rbt_e", "gene_reaction_rule": ""}, {"subsystem": "Lysine Metabolism", "name": "Glutarate-semialdehyde:NAD+ oxidoreductase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["OXPTNDH"]}, "metabolites": {"h2o_c": -1.0, "oxptn_c": -1.0, "h_c": 2.0, "nad_c": -1.0, "glutar_c": 1.0, "nadh_c": 1.0}, "id": "OXPTNDH", "gene_reaction_rule": "ECS88_2925"}, {"subsystem": "Exchange", "name": "Benzoate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_bz_LPAREN_e_RPAREN_"]}, "metabolites": {"bz_e": -1.0}, "id": "EX_bz_e", "gene_reaction_rule": ""}, {"subsystem": "Benzoate degradation", "name": "3-oxoadipyl-CoA thiolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3OXCOAT"]}, "metabolites": {"coa_c": -1.0, "succoa_c": 1.0, "oxadpcoa_c": -1.0, "accoa_c": 1.0}, "id": "3OXCOAT", "gene_reaction_rule": "ECS88_3141"}, {"subsystem": "Lysine Metabolism", "name": "Glutaryl-CoA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCOAS"]}, "metabolites": {"atp_c": -1.0, "glutcoa_c": 1.0, "coa_c": -1.0, "adp_c": 1.0, "glutar_c": -1.0, "pi_c": 1.0}, "id": "GLCOAS", "gene_reaction_rule": "ECS88_0754"}, {"subsystem": "Exchange", "name": "D-Arabitol exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_abt_D_LPAREN_e_RPAREN_"]}, "metabolites": {"abt__D_e": -1.0}, "id": "EX_abt__D_e", "gene_reaction_rule": ""}, {"subsystem": "Transport Inner Membrane", "name": "4 hydroxyphenylacetate transport in via proton symport periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["4HOXPACt2pp"]}, "metabolites": {"4hphac_p": -1.0, "4hphac_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "4HOXPACt2pp", "gene_reaction_rule": "rhmT"}, {"subsystem": "Transport; Inner Membrane", "name": "Cyanate transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYNTt2pp"]}, "metabolites": {"cynt_p": -1.0, "cynt_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "CYNTt2pp", "gene_reaction_rule": ""}, {"subsystem": "Transport; Inner Membrane", "name": "S-methylmethionine permease (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MMETt2pp"]}, "metabolites": {"mmet_p": -1.0, "h_c": 1.0, "h_p": -1.0, "mmet_c": 1.0}, "id": "MMETt2pp", "gene_reaction_rule": ""}, {"subsystem": "siderophore biosynthesis", "name": "Salicylate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SALSYN"]}, "metabolites": {"pyr_c": 1.0, "salc_c": 1.0, "ichor_c": -1.0}, "id": "SALSYN", "gene_reaction_rule": "ECS88_2032"}, {"subsystem": "Transport; Inner Membrane", "name": "2-O-alpha-mannosyl-D-glycerate transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MANGLYCptspp"]}, "metabolites": {"pep_c": -1.0, "man6pglyc_c": 1.0, "pyr_c": 1.0, "manglyc_p": -1.0}, "id": "MANGLYCptspp", "gene_reaction_rule": ""}, {"subsystem": "iron metabolism", "name": "Iron transporter", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FEex"]}, "metabolites": {"fe_p": 1.0, "fe_e": -1.0}, "id": "FEex", "gene_reaction_rule": "ECS88_2035 or ECS88_2034"}, {"subsystem": "iron metabolism", "name": "Iron transporter", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FEpp"]}, "metabolites": {"fe_c": 1.0, "fe_p": -1.0}, "id": "FEpp", "gene_reaction_rule": "ECS88_2035 or ECS88_2034"}, {"subsystem": "Transport; Inner Membrane", "name": "5-Dehydro-D-gluconate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["5DGLCNt2rpp"]}, "metabolites": {"5dglcn_p": -1.0, "5dglcn_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "5DGLCNt2rpp", "gene_reaction_rule": ""}, {"subsystem": "Transport; Inner Membrane", "name": "Psicoselysine transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PSCLYSt2pp"]}, "metabolites": {"psclys_c": 1.0, "h_c": 1.0, "h_p": -1.0, "psclys_p": -1.0}, "id": "PSCLYSt2pp", "gene_reaction_rule": ""}, {"subsystem": "Transport; Inner Membrane", "name": "Indole transport via proton symport, irreversible (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["INDOLEt2pp"]}, "metabolites": {"h_p": 1.0, "indole_c": -1.0, "indole_p": 1.0, "h_c": -1.0}, "id": "INDOLEt2pp", "gene_reaction_rule": "ECS88_0460"}, {"subsystem": "Oxidative Phosphorylation", "name": "Dimethyl sulfoxide reductase (Menaquinol 8) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DMSOR1pp"]}, "metabolites": {"dmso_p": -1.0, "h2o_p": 1.0, "dms_p": 1.0, "mqn8_c": 1.0, "mql8_c": -1.0}, "id": "DMSOR1pp", "gene_reaction_rule": ""}, {"subsystem": "Transport; Inner Membrane", "name": "L-idonate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IDONt2rpp"]}, "metabolites": {"idon__L_c": 1.0, "idon__L_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "IDONt2rpp", "gene_reaction_rule": ""}, {"subsystem": "Transport; Inner Membrane", "name": "3-(3-hydroxyphenyl)propionate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HPPPNt2rpp"]}, "metabolites": {"3hpppn_p": -1.0, "h_c": 1.0, "h_p": -1.0, "3hpppn_c": 1.0}, "id": "HPPPNt2rpp", "gene_reaction_rule": ""}, {"subsystem": "purine metabolism", "name": "Deoxyadenylate kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DADK", "DAMPK"]}, "metabolites": {"dadp_c": 1.0, "damp_c": -1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "DADK_copy2", "gene_reaction_rule": "ECS88_0471"}, {"subsystem": "Exchange", "name": "Fe[e] Exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_fe_LPAREN_e_RPAREN_"]}, "metabolites": {"fe_e": -1.0}, "id": "EX_fe_e", "gene_reaction_rule": ""}, {"subsystem": "Transport; Inner Membrane", "name": "3-hydroxycinnamic acid transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HCINNMt2rpp"]}, "metabolites": {"h_p": -1.0, "h_c": 1.0, "3hcinnm_p": -1.0, "3hcinnm_c": 1.0}, "id": "HCINNMt2rpp", "gene_reaction_rule": ""}, {"subsystem": "Extracellular exchange", "name": "KO-KDO-LipidA Exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_KOKDOLIPA_LPAREN_e_RPAREN_"]}, "metabolites": {"kokdolipidA_e": -1.0}, "id": "EX_kokdolipidA_e", "gene_reaction_rule": ""}, {"subsystem": "S_Alternate_Carbon_source", "name": "N Acetyl D Galactosamine 6 phosphate isomerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALAM6PISO"]}, "metabolites": {"h2o_c": -1.0, "galam6p_c": -1.0, "tag6p__D_c": 1.0, "nh4_c": 1.0}, "id": "GALAM6PISO", "gene_reaction_rule": "ECS88_3529"}, {"subsystem": "S_Alternate_Carbon_Metabolism", "name": "Salicin hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SALCNH"]}, "metabolites": {"glc__D_c": 1.0, "h2o_c": -1.0, "2hymeph_c": 1.0, "salcn_c": -1.0}, "id": "SALCNH", "gene_reaction_rule": "ECS88_1609"}, {"subsystem": "S_Transport_Outer_Membrane_Porin", "name": "Cellobiose transport transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": 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{"original_bigg_ids": ["NICRNS"]}, "metabolites": {"nicrnt_c": 1.0, "nicrns_c": -1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "NICRNS", "gene_reaction_rule": "ECS88_4396 or ECS88_4394 or ECS88_4393"}, {"name": "UDP-L-rhamnose:flavonol-3-O-D-glucoside L-rhamnosyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["URFGTT"]}, "metabolites": {"amet_c": -1.0, "2ommb_c": 1.0, "ahcys_c": 1.0, "h_c": 1.0, "2ombz_c": -1.0}, "id": "URFGTT", "gene_reaction_rule": "ECS88_4283"}, {"name": "Acyl-CoA dehydrogenase (decanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACOAD4"]}, "metabolites": {"nadh_c": 1.0, "dc2coa_c": 1.0, "h_c": 1.0, "nad_c": -1.0, "dcacoa_c": -1.0}, "id": "ACOAD4", "gene_reaction_rule": "ECS88_0258"}, {"name": "Arabino-3-hexulose-6-P Isomerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AH6PI"]}, "metabolites": {"ah6p__D_c": -1.0, "f6p_c": 1.0}, "id": "AH6PI", "gene_reaction_rule": "ECS88_4262"}, {"name": "Acyl-CoA dehydrogenase (hexanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACOAD2"]}, "metabolites": {"h_c": -1.0, "nadh_c": -1.0, "hxcoa_c": 1.0, "nad_c": 1.0, "hx2coa_c": -1.0}, "id": "ACOAD2", "gene_reaction_rule": "ECS88_0258"}, {"name": "Acyl-CoA dehydrogenase (octanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACOAD3"]}, "metabolites": {"oc2coa_c": 1.0, "nadh_c": 1.0, "occoa_c": -1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "ACOAD3", "gene_reaction_rule": "ECS88_0258"}, {"name": "Acyl-CoA dehydrogenase (tetradecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACOAD6"]}, "metabolites": {"nad_c": -1.0, "nadh_c": 1.0, "h_c": 1.0, "tdcoa_c": -1.0, "td2coa_c": 1.0}, "id": "ACOAD6", "gene_reaction_rule": "ECS88_0258"}, {"name": "Nicotinamide ribonucleotide phosphohydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NMNHYD"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "nmn_c": -1.0, "rnam_c": 1.0}, "id": "NMNHYD", "gene_reaction_rule": "ECS88_4396 or ECS88_4394 or ECS88_4393"}, {"name": "3-hydroxyisobutyryl-CoA hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3HBCOAHL"]}, "metabolites": {"h2o_c": -1.0, "coa_c": 1.0, "h_c": 1.0, "3hmp_c": 1.0, "3hibutcoa_c": -1.0}, "id": "3HBCOAHL", "gene_reaction_rule": "ECS88_4526 or ECS88_4796"}, {"name": "(S)-Malate:(acceptor) oxidoreductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DMALRED"]}, "metabolites": {"fad_c": -1.0, "fadh2_c": 1.0, "mal__L_c": -1.0, "oaa_c": 1.0}, "id": "DMALRED", "gene_reaction_rule": "ECS88_2358"}, {"name": "S-adenosylmethione:2-demethylmenaquinone methyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMMQT8_2"]}, "metabolites": {"amet_c": -1.0, "ahcys_c": 1.0, "mqn8_c": 1.0, "2dmmq8_c": -1.0, "h_c": 1.0}, "id": "AMMQT8_2", "gene_reaction_rule": "ECS88_4283"}, {"name": "Pyruvate dehydrogenase (dihydrolipoamide dehydrogenase) reversible", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PDHcr"]}, "metabolites": {"lpam_c": 1.0, "nadh_c": 1.0, "dhlam_c": -1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "PDHcr", "gene_reaction_rule": "ECS88_4536"}, {"name": "Phenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPOR"]}, "metabolites": {"phpyr_c": -1.0, "o2_c": -1.0, "2hyoxplac_c": 1.0, "co2_c": 1.0}, "id": "PPOR", "gene_reaction_rule": "ECS88_4797"}, {"name": "Cellobiose transport via PEP:Pyr PTS", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CELLBpts"]}, "metabolites": {"pyr_p": 1.0, "pep_p": -1.0, "6pgg_c": 1.0, "cellb_e": -1.0}, "id": "CELLBpts", "gene_reaction_rule": "ECS88_1613"}, {"name": "Lysine 2,3-aminomutase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSAM"]}, "metabolites": {"36dahx_c": 1.0, "lys__L_c": -1.0}, "id": "LYSAM", "gene_reaction_rule": "ECS88_4732"}], "genes": [{"notes": {"original_bigg_ids": ["ECS88_0276"]}, "name": "phoE", "id": "ECS88_0276"}, {"notes": {"original_bigg_ids": ["ECS88_0957"]}, "name": "ompF", "id": "ECS88_0957"}, {"notes": {"original_bigg_ids": ["ECS88_1492"]}, "name": "ompN", "id": "ECS88_1492"}, {"notes": {"original_bigg_ids": ["ECS88_2364"]}, "name": "ompC", "id": "ECS88_2364"}, {"notes": {"original_bigg_ids": ["ECS88_4506"]}, "name": "malG", "id": "ECS88_4506"}, {"notes": {"original_bigg_ids": ["ECS88_4507"]}, "name": "malF", "id": "ECS88_4507"}, {"notes": {"original_bigg_ids": ["ECS88_4509"]}, "name": "malK", "id": "ECS88_4509"}, {"notes": {"original_bigg_ids": ["ECS88_4508"]}, "name": "malE", "id": "ECS88_4508"}, {"notes": {"original_bigg_ids": ["ECS88_4510"]}, "name": "lamB", "id": "ECS88_4510"}, {"notes": {"original_bigg_ids": ["ECS88_4807"]}, "name": "cpdB", "id": "ECS88_4807"}, {"notes": {"original_bigg_ids": ["ECS88_3130"]}, "name": "ygeD", "id": "ECS88_3130"}, {"notes": {"original_bigg_ids": ["ECS88_3131"]}, "name": "aas", "id": "ECS88_3131"}, {"notes": {"original_bigg_ids": ["ECS88_3972"]}, "name": "tiaE", "id": "ECS88_3972"}, {"notes": {"original_bigg_ids": ["ECS88_0443"]}, "name": "cof", "id": "ECS88_0443"}, {"notes": {"original_bigg_ids": ["ECS88_1149"]}, "name": "ymfB", "id": "ECS88_1149"}, {"notes": {"original_bigg_ids": ["ECS88_1025"]}, "name": "rutD", "id": "ECS88_1025"}, {"notes": {"original_bigg_ids": ["ECS88_0191"]}, "name": "fabZ", "id": "ECS88_0191"}, {"notes": {"original_bigg_ids": ["ECS88_0975"]}, "name": "fabA", "id": "ECS88_0975"}, {"notes": {"original_bigg_ids": ["ECS88_4000"]}, "name": "lyxK", "id": "ECS88_4000"}, {"notes": {"original_bigg_ids": ["ECS88_1107"]}, "name": "fabG", "id": "ECS88_1107"}, {"notes": {"original_bigg_ids": ["ECS88_2471"]}, "name": "fabB", "id": "ECS88_2471"}, {"notes": {"original_bigg_ids": ["ECS88_1109"]}, "name": "fabF", "id": "ECS88_1109"}, {"notes": {"original_bigg_ids": ["ECS88_1312"]}, "name": "oppB", "id": "ECS88_1312"}, {"notes": {"original_bigg_ids": ["ECS88_1315"]}, "name": "oppF", "id": "ECS88_1315"}, {"notes": {"original_bigg_ids": ["ECS88_1313"]}, "name": "oppC", "id": "ECS88_1313"}, {"notes": {"original_bigg_ids": ["ECS88_1314"]}, "name": "oppD", "id": "ECS88_1314"}, {"notes": {"original_bigg_ids": ["ECS88_1472"]}, "name": "mppA", "id": "ECS88_1472"}, {"notes": {"original_bigg_ids": ["ECS88_0004"]}, "name": "thrC", "id": "ECS88_0004"}, {"notes": {"original_bigg_ids": ["ECS88_1255"]}, "name": "ldcA", "id": "ECS88_1255"}, {"notes": {"original_bigg_ids": ["ECS88_1311"]}, "name": "oppA", "id": "ECS88_1311"}, {"notes": {"original_bigg_ids": ["ECS88_0170"]}, "name": "pfs", "id": "ECS88_0170"}, {"notes": {"original_bigg_ids": ["ECS88_3580"]}, "name": "kdsD", "id": "ECS88_3580"}, {"notes": {"original_bigg_ids": ["ECS88_2971"]}, "name": "gutQ", "id": "ECS88_2971"}, {"notes": {"original_bigg_ids": ["ECS88_1108"]}, "name": "acpP", "id": "ECS88_1108"}, {"notes": {"original_bigg_ids": ["ECS88_4215"]}, "name": "rffT", "id": "ECS88_4215"}, {"notes": {"original_bigg_ids": ["ECS88_1981"]}, "name": "amyA", "id": "ECS88_1981"}, {"notes": {"original_bigg_ids": ["ECS88_3990"]}, "name": "malS", "id": "ECS88_3990"}, {"notes": {"original_bigg_ids": ["ECS88_3181"]}, "name": "bglA", "id": "ECS88_3181"}, {"notes": {"original_bigg_ids": ["ECS88_2926"]}, "name": "gabT", "id": "ECS88_2926"}, {"notes": {"original_bigg_ids": ["ECS88_1538"]}, "name": "ydcW", "id": "ECS88_1538"}, {"notes": {"original_bigg_ids": ["ECS88_2927"]}, "name": "gabP", "id": "ECS88_2927"}, {"notes": {"original_bigg_ids": ["ECS88_2370"]}, "name": "atoD", "id": "ECS88_2370"}, {"notes": {"original_bigg_ids": ["ECS88_2371"]}, "name": "atoA", "id": "ECS88_2371"}, {"notes": {"original_bigg_ids": ["ECS88_4293"]}, "name": "fadA", "id": "ECS88_4293"}, {"notes": {"original_bigg_ids": ["ECS88_2489"]}, "name": "yfcY", "id": "ECS88_2489"}, {"notes": {"original_bigg_ids": ["ECS88_2373"]}, "name": "atoB", "id": "ECS88_2373"}, {"notes": {"original_bigg_ids": ["ECS88_2372"]}, "name": "atoE", "id": "ECS88_2372"}, {"notes": {"original_bigg_ids": ["ECS88_1308"]}, "name": "adhE", "id": "ECS88_1308"}, {"notes": {"original_bigg_ids": ["s0001"]}, "name": "None", "id": "s0001"}, {"notes": {"original_bigg_ids": ["ECS88_1558"]}, "name": "nhoA", "id": "ECS88_1558"}, {"notes": {"original_bigg_ids": ["ECS88_2058"]}, "name": "cobU", "id": "ECS88_2058"}, {"notes": {"original_bigg_ids": ["ECS88_3632"]}, "name": "accC", "id": "ECS88_3632"}, {"notes": {"original_bigg_ids": ["ECS88_3631"]}, "name": "accB", "id": "ECS88_3631"}, {"notes": {"original_bigg_ids": ["ECS88_0196"]}, "name": "accA", "id": "ECS88_0196"}, {"notes": {"original_bigg_ids": ["ECS88_2463"]}, "name": "accD", "id": "ECS88_2463"}, {"notes": {"original_bigg_ids": ["ECS88_4562"]}, "name": "acs", "id": "ECS88_4562"}, {"notes": {"original_bigg_ids": ["ECS88_1133"]}, "name": "ycfX", "id": "ECS88_1133"}, {"notes": {"original_bigg_ids": ["ECS88_4206"]}, "name": "rfe", "id": "ECS88_4206"}, {"notes": {"original_bigg_ids": ["ECS88_2607"]}, "name": "crr", "id": "ECS88_2607"}, {"notes": {"original_bigg_ids": ["ECS88_0704"]}, "name": "nagE", "id": "ECS88_0704"}, {"notes": {"original_bigg_ids": ["ECS88_2606"]}, "name": "ptsI", "id": "ECS88_2606"}, {"notes": {"original_bigg_ids": ["ECS88_1115"]}, "name": "ptsG", "id": "ECS88_1115"}, {"notes": {"original_bigg_ids": ["ECS88_2605"]}, "name": "ptsH", "id": "ECS88_2605"}, {"notes": {"original_bigg_ids": ["ECS88_4414"]}, "name": "argB", "id": "ECS88_4414"}, {"notes": {"original_bigg_ids": ["ECS88_3113"]}, "name": "argA", "id": "ECS88_3113"}, {"notes": {"original_bigg_ids": ["ECS88_4095"]}, "name": "ilvN", "id": "ECS88_4095"}, {"notes": {"original_bigg_ids": ["ECS88_0081"]}, "name": "ilvI", "id": "ECS88_0081"}, {"notes": {"original_bigg_ids": ["ECS88_4096"]}, "name": "ilvB", "id": "ECS88_4096"}, {"notes": {"original_bigg_ids": ["ECS88_0082"]}, "name": "ilvH", "id": "ECS88_0082"}, {"notes": {"original_bigg_ids": ["ECS88_1905"]}, "name": "purT", "id": "ECS88_1905"}, {"notes": {"original_bigg_ids": ["ECS88_3508"]}, "name": "tdcD", "id": "ECS88_3508"}, {"notes": {"original_bigg_ids": ["ECS88_2443"]}, "name": "ackA", "id": "ECS88_2443"}, {"notes": {"original_bigg_ids": ["ECS88_2616"]}, "name": "yfeU", "id": "ECS88_2616"}, {"notes": {"original_bigg_ids": ["ECS88_4218"]}, "name": "rffM", "id": "ECS88_4218"}, {"notes": {"original_bigg_ids": ["ECS88_1870"]}, "name": "manY", "id": "ECS88_1870"}, {"notes": {"original_bigg_ids": ["ECS88_1869"]}, "name": "manX", "id": "ECS88_1869"}, {"notes": {"original_bigg_ids": ["ECS88_1871"]}, "name": "manZ", "id": "ECS88_1871"}, {"notes": {"original_bigg_ids": ["ECS88_2617"]}, "name": "murP", "id": "ECS88_2617"}, {"notes": {"original_bigg_ids": ["ECS88_3601"]}, "name": "nanT", "id": "ECS88_3601"}, {"notes": {"original_bigg_ids": ["ECS88_4928"]}, "name": "yjhA", "id": "ECS88_4928"}, {"notes": {"original_bigg_ids": ["ECS88_3602"]}, "name": "nanA", "id": "ECS88_3602"}, {"notes": {"original_bigg_ids": ["ECS88_0258"]}, "name": "fadE", "id": "ECS88_0258"}, {"notes": {"original_bigg_ids": ["ECS88_1105"]}, "name": "fabH", "id": "ECS88_1105"}, {"notes": {"original_bigg_ids": ["ECS88_4412"]}, "name": "argE", "id": "ECS88_4412"}, {"notes": {"original_bigg_ids": ["ECS88_3583"]}, "name": "lptA", "id": "ECS88_3583"}, {"notes": {"original_bigg_ids": ["ECS88_4848"]}, "name": "yjgP", "id": "ECS88_4848"}, {"notes": {"original_bigg_ids": ["ECS88_3584"]}, "name": "lptB", "id": "ECS88_3584"}, {"notes": {"original_bigg_ids": ["ECS88_4849"]}, "name": "yjgQ", "id": "ECS88_4849"}, {"notes": {"original_bigg_ids": ["ECS88_3582"]}, "name": "yrbK", "id": "ECS88_3582"}, {"notes": {"original_bigg_ids": ["ECS88_1596"]}, "name": "tam", "id": "ECS88_1596"}, {"notes": {"original_bigg_ids": ["ECS88_0127"]}, "name": "acnB", "id": "ECS88_0127"}, {"notes": {"original_bigg_ids": ["ECS88_1416"]}, "name": "acnA", "id": "ECS88_1416"}, {"notes": {"original_bigg_ids": ["ECS88_3750"]}, "name": "argD", "id": "ECS88_3750"}, {"notes": {"original_bigg_ids": ["ECS88_1800"]}, "name": "astC", "id": "ECS88_1800"}, {"notes": {"original_bigg_ids": ["ECS88_1104"]}, "name": "plsX", "id": "ECS88_1104"}, {"notes": {"original_bigg_ids": ["ECS88_3878"]}, "name": "acpT", "id": "ECS88_3878"}, {"notes": {"original_bigg_ids": ["ECS88_2736"]}, "name": "acpS", "id": "ECS88_2736"}, {"notes": {"original_bigg_ids": ["ECS88_1615"]}, "name": "eamA", "id": "ECS88_1615"}, {"notes": {"original_bigg_ids": ["ECS88_2752"]}, "name": "yfiK", "id": "ECS88_2752"}, {"notes": {"original_bigg_ids": ["ECS88_4560"]}, "name": "actP", "id": "ECS88_4560"}, {"notes": {"original_bigg_ids": ["ECS88_1670"]}, "name": "add", "id": "ECS88_1670"}, {"notes": {"original_bigg_ids": ["ECS88_1110"]}, "name": "pabC", "id": "ECS88_1110"}, {"notes": {"original_bigg_ids": ["ECS88_3751"]}, "name": "pabA", "id": "ECS88_3751"}, {"notes": {"original_bigg_ids": ["ECS88_1864"]}, "name": "pabB", "id": "ECS88_1864"}, {"notes": {"original_bigg_ids": ["ECS88_4090"]}, "name": "ade", "id": "ECS88_4090"}, {"notes": {"original_bigg_ids": ["ECS88_4070"]}, "name": "yicE", "id": "ECS88_4070"}, {"notes": {"original_bigg_ids": ["ECS88_4089"]}, "name": "yicO", "id": "ECS88_4089"}, {"notes": {"original_bigg_ids": ["ECS88_0471"]}, "name": "adk", "id": "ECS88_0471"}, {"notes": {"original_bigg_ids": ["ECS88_0129"]}, "name": "speD", "id": "ECS88_0129"}, {"notes": {"original_bigg_ids": ["ECS88_4229"]}, "name": "cyaA", "id": "ECS88_4229"}, {"notes": {"original_bigg_ids": ["ECS88_0029"]}, "name": "rihC", "id": "ECS88_0029"}, {"notes": {"original_bigg_ids": ["ECS88_3247"]}, "name": "nupG", "id": "ECS88_3247"}, {"notes": {"original_bigg_ids": ["ECS88_2587"]}, "name": "nupC", "id": "ECS88_2587"}, {"notes": {"original_bigg_ids": ["ECS88_2595"]}, "name": "xapB", 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{"notes": {"original_bigg_ids": ["ECS88_0978"]}, "name": "ompA", "id": "ECS88_0978"}, {"notes": {"original_bigg_ids": ["ECS88_1461"]}, "name": "ompG", "id": "ECS88_1461"}, {"notes": {"original_bigg_ids": ["ECS88_0897"]}, "name": "aqpZ", "id": "ECS88_0897"}, {"notes": {"original_bigg_ids": ["ECS88_4513"]}, "name": "ubiA", "id": "ECS88_4513"}, {"notes": {"original_bigg_ids": ["ECS88_0135"]}, "name": "can", "id": "ECS88_0135"}, {"notes": {"original_bigg_ids": ["ECS88_0424"]}, "name": "cyoE", "id": "ECS88_0424"}, {"notes": {"original_bigg_ids": ["ECS88_4044"]}, "name": "waaP", "id": "ECS88_4044"}, {"notes": {"original_bigg_ids": ["ECS88_4037"]}, "name": "waaC", "id": "ECS88_4037"}, {"notes": {"original_bigg_ids": ["ECS88_4036"]}, "name": "waaF", "id": "ECS88_4036"}, {"notes": {"original_bigg_ids": ["ECS88_4046"]}, "name": "waaQ", "id": "ECS88_4046"}, {"notes": {"original_bigg_ids": ["ECS88_2246"]}, "name": "thiM", "id": "ECS88_2246"}, {"notes": {"original_bigg_ids": ["ECS88_2583"]}, "name": "glk", "id": "ECS88_2583"}, {"notes": {"original_bigg_ids": ["ECS88_0389"]}, "name": "mak", "id": "ECS88_0389"}, {"notes": {"original_bigg_ids": ["ECS88_2119"]}, "name": "hisD", "id": "ECS88_2119"}, {"notes": {"original_bigg_ids": ["ECS88_2121"]}, "name": "hisB", "id": "ECS88_2121"}, {"notes": {"original_bigg_ids": ["ECS88_2690"]}, "name": "hisS", "id": "ECS88_2690"}, {"notes": {"original_bigg_ids": ["ECS88_2456"]}, "name": "hisJ", "id": "ECS88_2456"}, {"notes": {"original_bigg_ids": ["ECS88_0114"]}, "name": "aroP", "id": "ECS88_0114"}, {"notes": {"original_bigg_ids": ["ECS88_4227"]}, "name": "hemC", "id": "ECS88_4227"}, {"notes": {"original_bigg_ids": ["ECS88_2245"]}, "name": "thiD", "id": "ECS88_2245"}, {"notes": {"original_bigg_ids": ["ECS88_2608"]}, "name": "pdxK", "id": "ECS88_2608"}, {"notes": {"original_bigg_ids": ["ECS88_4252"]}, "name": "rhtB", "id": "ECS88_4252"}, {"notes": {"original_bigg_ids": ["ECS88_0831"]}, "name": "rhtA", "id": "ECS88_0831"}, {"notes": {"original_bigg_ids": ["ECS88_0152"]}, "name": "folK", "id": "ECS88_0152"}, {"notes": {"original_bigg_ids": ["ECS88_0507"]}, "name": "hyi", "id": "ECS88_0507"}, {"notes": {"original_bigg_ids": ["ECS88_0003"]}, "name": "thrB", "id": "ECS88_0003"}, {"notes": {"original_bigg_ids": ["ECS88_4478"]}, "name": "metA", "id": "ECS88_4478"}, {"notes": {"original_bigg_ids": ["ECS88_2120"]}, "name": "hisC", "id": "ECS88_2120"}, {"notes": {"original_bigg_ids": ["ECS88_3147"]}, "name": "xdhC", "id": "ECS88_3147"}, {"notes": {"original_bigg_ids": ["ECS88_3145"]}, "name": "xdhA", "id": "ECS88_3145"}, {"notes": {"original_bigg_ids": ["ECS88_3146"]}, "name": "xdhB", "id": "ECS88_3146"}, {"notes": {"original_bigg_ids": ["ECS88_3378"]}, "name": "hybA", "id": "ECS88_3378"}, {"notes": {"original_bigg_ids": ["ECS88_3376"]}, "name": "hybC", "id": "ECS88_3376"}, {"notes": {"original_bigg_ids": ["ECS88_0995"]}, "name": "hyaB", "id": "ECS88_0995"}, {"notes": {"original_bigg_ids": ["ECS88_0996"]}, "name": "hyaC", "id": "ECS88_0996"}, {"notes": {"original_bigg_ids": ["ECS88_3379"]}, "name": "hybO", "id": "ECS88_3379"}, {"notes": {"original_bigg_ids": ["ECS88_0994"]}, "name": "hyaA", "id": "ECS88_0994"}, {"notes": {"original_bigg_ids": ["ECS88_3377"]}, "name": "hybB", "id": "ECS88_3377"}, {"notes": {"original_bigg_ids": ["ECS88_2705"]}, "name": "iscU", "id": "ECS88_2705"}, {"notes": {"original_bigg_ids": ["ECS88_2706"]}, "name": "iscS", "id": "ECS88_2706"}, {"notes": {"original_bigg_ids": ["ECS88_4230"]}, "name": "cyaY", "id": "ECS88_4230"}, {"notes": {"original_bigg_ids": ["ECS88_2704"]}, "name": "iscA", "id": "ECS88_2704"}, {"notes": {"original_bigg_ids": ["ECS88_1151"]}, "name": "icd", "id": "ECS88_1151"}, {"notes": {"original_bigg_ids": ["ECS88_2416"]}, "name": "menF", "id": "ECS88_2416"}, {"notes": {"original_bigg_ids": ["ECS88_0632"]}, "name": "entC", "id": "ECS88_0632"}, {"notes": {"original_bigg_ids": ["ECS88_0634"]}, "name": "entB", "id": "ECS88_0634"}, {"notes": {"original_bigg_ids": ["ECS88_4480"]}, "name": "aceA", "id": "ECS88_4480"}, {"notes": {"original_bigg_ids": ["ECS88_2124"]}, "name": "hisF", "id": "ECS88_2124"}, {"notes": {"original_bigg_ids": ["ECS88_2122"]}, "name": "hisH", "id": "ECS88_2122"}, {"notes": {"original_bigg_ids": ["ECS88_1397"]}, "name": "trpC", "id": "ECS88_1397"}, {"notes": {"original_bigg_ids": ["ECS88_4193"]}, "name": "ilvE", "id": "ECS88_4193"}, {"notes": {"original_bigg_ids": ["ECS88_0025"]}, "name": "ileS", "id": "ECS88_0025"}, {"notes": {"original_bigg_ids": ["ECS88_0396"]}, "name": "brnQ", "id": "ECS88_0396"}, {"notes": {"original_bigg_ids": ["ECS88_2680"]}, "name": "guaB", "id": "ECS88_2680"}, {"notes": {"original_bigg_ids": ["ECS88_3545"]}, "name": "mtr", "id": "ECS88_3545"}, {"notes": {"original_bigg_ids": ["ECS88_3169"]}, "name": "idi", "id": "ECS88_3169"}, {"notes": {"original_bigg_ids": ["ECS88_0078"]}, "name": "leuB", "id": "ECS88_0078"}, {"notes": {"original_bigg_ids": ["ECS88_0077"]}, "name": "leuC", "id": "ECS88_0077"}, {"notes": {"original_bigg_ids": ["ECS88_0076"]}, "name": "leuD", "id": "ECS88_0076"}, {"notes": {"original_bigg_ids": ["ECS88_0079"]}, "name": "leuA", "id": "ECS88_0079"}, {"notes": {"original_bigg_ids": ["ECS88_0946"]}, "name": "kdsB", "id": "ECS88_0946"}, {"notes": {"original_bigg_ids": ["ECS88_3581"]}, "name": "kdsC", "id": "ECS88_3581"}, {"notes": {"original_bigg_ids": ["ECS88_1283"]}, "name": "kdsA", "id": "ECS88_1283"}, {"notes": {"original_bigg_ids": ["ECS88_4782"]}, "name": "ulaD", "id": "ECS88_4782"}, {"notes": {"original_bigg_ids": ["ECS88_4001"]}, "name": "sgbH", "id": "ECS88_4001"}, {"notes": {"original_bigg_ids": ["ECS88_0731"]}, "name": "kdpB", "id": "ECS88_0731"}, {"notes": {"original_bigg_ids": ["ECS88_0730"]}, "name": "kdpC", "id": "ECS88_0730"}, {"notes": {"original_bigg_ids": ["ECS88_0732"]}, "name": "kdpA", "id": "ECS88_0732"}, {"notes": {"original_bigg_ids": ["ECS88_0733"]}, "name": "kdpF", "id": "ECS88_0733"}, {"notes": {"original_bigg_ids": ["ECS88_1437"]}, "name": "sapD", "id": "ECS88_1437"}, {"notes": {"original_bigg_ids": ["ECS88_3677"]}, "name": "trkA", "id": "ECS88_3677"}, {"notes": {"original_bigg_ids": ["ECS88_1319"]}, "name": "kch", "id": "ECS88_1319"}, {"notes": {"original_bigg_ids": ["ECS88_4169"]}, "name": "trkD", "id": "ECS88_4169"}, {"notes": {"original_bigg_ids": ["ECS88_4297"]}, "name": "trkH", "id": "ECS88_4297"}, {"notes": {"original_bigg_ids": ["ECS88_3739"]}, "name": "kefB", "id": "ECS88_3739"}, {"notes": {"original_bigg_ids": ["ECS88_0050"]}, "name": "kefC", "id": "ECS88_0050"}, {"notes": {"original_bigg_ids": ["ECS88_0859"]}, "name": "cmr", "id": "ECS88_0859"}, {"notes": {"original_bigg_ids": ["ECS88_4022"]}, "name": "lldD", "id": "ECS88_4022"}, {"notes": {"original_bigg_ids": ["ECS88_0307"]}, "name": "ykgE", "id": "ECS88_0307"}, {"notes": {"original_bigg_ids": ["ECS88_0309"]}, "name": "ykgG", "id": "ECS88_0309"}, {"notes": {"original_bigg_ids": ["ECS88_0308"]}, "name": "ykgF", "id": "ECS88_0308"}, {"notes": {"original_bigg_ids": ["ECS88_2407"]}, "name": "arnT", "id": "ECS88_2407"}, {"notes": {"original_bigg_ids": ["ECS88_0351"]}, "name": "lacZ", "id": "ECS88_0351"}, {"notes": {"original_bigg_ids": ["ECS88_2276"]}, "name": "bglX", "id": "ECS88_2276"}, {"notes": {"original_bigg_ids": ["ECS88_1468"]}, "name": "mpaA", "id": "ECS88_1468"}, {"notes": {"original_bigg_ids": ["ECS88_4634"]}, "name": "yjdL", "id": "ECS88_4634"}, {"notes": {"original_bigg_ids": ["ECS88_3901"]}, "name": "yhiP", "id": "ECS88_3901"}, {"notes": {"original_bigg_ids": ["ECS88_0737"]}, "name": "ybgH", "id": "ECS88_0737"}, {"notes": {"original_bigg_ids": ["ECS88_1682"]}, "name": "ydgR", "id": "ECS88_1682"}, {"notes": {"original_bigg_ids": ["ECS88_3068"]}, "name": "fucO", "id": "ECS88_3068"}, {"notes": {"original_bigg_ids": ["ECS88_2318"]}, "name": "setB", "id": "ECS88_2318"}, {"notes": {"original_bigg_ids": ["ECS88_0350"]}, "name": "lacY", "id": "ECS88_0350"}, {"notes": {"original_bigg_ids": ["ECS88_2277"]}, "name": "dld", "id": "ECS88_2277"}, {"notes": {"original_bigg_ids": ["ECS88_1496"]}, "name": "ldhA", "id": "ECS88_1496"}, {"notes": {"original_bigg_ids": ["ECS88_4533"]}, "name": "tyrB", "id": "ECS88_4533"}, {"notes": {"original_bigg_ids": ["ECS88_0684"]}, "name": "leuS", "id": "ECS88_0684"}, {"notes": {"original_bigg_ids": ["ECS88_3855"]}, "name": "livK", "id": "ECS88_3855"}, {"notes": {"original_bigg_ids": ["ECS88_1700"]}, "name": "gloA", "id": "ECS88_1700"}, {"notes": {"original_bigg_ids": ["ECS88_0664"]}, "name": "crcA", "id": "ECS88_0664"}, {"notes": {"original_bigg_ids": ["ECS88_5067"]}, "name": "lplA", "id": "ECS88_5067"}, {"notes": {"original_bigg_ids": ["ECS88_0671"]}, "name": "lipB", "id": "ECS88_0671"}, {"notes": {"original_bigg_ids": ["ECS88_0669"]}, "name": "lipA", "id": "ECS88_0669"}, {"notes": {"original_bigg_ids": ["ECS88_0193"]}, "name": "lpxB", "id": "ECS88_0193"}, {"notes": {"original_bigg_ids": ["ECS88_0499"]}, "name": "tesA", "id": "ECS88_0499"}, {"notes": {"original_bigg_ids": 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{"original_bigg_ids": ["ECS88_4941"]}, "name": "uxuB", "id": "ECS88_4941"}, {"notes": {"original_bigg_ids": ["ECS88_0345"]}, "name": "prpD", "id": "ECS88_0345"}, {"notes": {"original_bigg_ids": ["ECS88_0343"]}, "name": "prpB", "id": "ECS88_0343"}, {"notes": {"original_bigg_ids": ["ECS88_0344"]}, "name": "prpC", "id": "ECS88_0344"}, {"notes": {"original_bigg_ids": ["ECS88_1106"]}, "name": "fabD", "id": "ECS88_1106"}, {"notes": {"original_bigg_ids": ["ECS88_2697"]}, "name": "sseA", "id": "ECS88_2697"}, {"notes": {"original_bigg_ids": ["ECS88_0677"]}, "name": "mrdA", "id": "ECS88_0677"}, {"notes": {"original_bigg_ids": ["ECS88_0087"]}, "name": "ftsI", "id": "ECS88_0087"}, {"notes": {"original_bigg_ids": ["ECS88_3782"]}, "name": "mrcA", "id": "ECS88_3782"}, {"notes": {"original_bigg_ids": ["ECS88_0159"]}, "name": "mrcB", "id": "ECS88_0159"}, {"notes": {"original_bigg_ids": ["ECS88_0673"]}, "name": "dacA", "id": "ECS88_0673"}, {"notes": {"original_bigg_ids": ["ECS88_3564"]}, "name": "dacB", "id": "ECS88_3564"}, {"notes": {"original_bigg_ids": ["ECS88_0856"]}, "name": "dacC", "id": "ECS88_0856"}, {"notes": {"original_bigg_ids": ["ECS88_2109"]}, "name": "dacD", "id": "ECS88_2109"}, {"notes": {"original_bigg_ids": ["ECS88_2278"]}, "name": "pbpG", "id": "ECS88_2278"}, {"notes": {"original_bigg_ids": ["ECS88_2476"]}, "name": "mepA", "id": "ECS88_2476"}, {"notes": {"original_bigg_ids": ["ECS88_3612"]}, "name": "mdh", "id": "ECS88_3612"}, {"notes": {"original_bigg_ids": ["ECS88_2358"]}, "name": "mqo", "id": "ECS88_2358"}, {"notes": {"original_bigg_ids": ["ECS88_1573"]}, "name": "sfcA", "id": "ECS88_1573"}, {"notes": {"original_bigg_ids": ["ECS88_2642"]}, "name": "maeB", "id": "ECS88_2642"}, {"notes": {"original_bigg_ids": ["ECS88_2691"]}, "name": "ispG", "id": "ECS88_2691"}, {"notes": {"original_bigg_ids": ["ECS88_3016"]}, "name": "ispF", "id": "ECS88_3016"}, {"notes": {"original_bigg_ids": ["ECS88_3017"]}, "name": "ispD", "id": "ECS88_3017"}, {"notes": {"original_bigg_ids": 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{"notes": {"original_bigg_ids": ["ECS88_2730"]}, "name": "yfhD", "id": "ECS88_2730"}, {"notes": {"original_bigg_ids": ["ECS88_5075"]}, "name": "slt", "id": "ECS88_5075"}, {"notes": {"original_bigg_ids": ["ECS88_3082"]}, "name": "mltA", "id": "ECS88_3082"}, {"notes": {"original_bigg_ids": ["ECS88_1256"]}, "name": "emtA", "id": "ECS88_1256"}, {"notes": {"original_bigg_ids": ["ECS88_2964"]}, "name": "mltB", "id": "ECS88_2964"}, {"notes": {"original_bigg_ids": ["ECS88_3246"]}, "name": "mltC", "id": "ECS88_3246"}, {"notes": {"original_bigg_ids": ["scpC"]}, "name": "None", "id": "scpC"}, {"notes": {"original_bigg_ids": ["ECS88_4012"]}, "name": "mtlA", "id": "ECS88_4012"}, {"notes": {"original_bigg_ids": ["ECS88_4940"]}, "name": "uxuA", "id": "ECS88_4940"}, {"notes": {"original_bigg_ids": ["ECS88_0801"]}, "name": "moaD", "id": "ECS88_0801"}, {"notes": {"original_bigg_ids": ["ECS88_4047"]}, "name": "kdtA", "id": "ECS88_4047"}, {"notes": {"original_bigg_ids": ["ECS88_2612"]}, "name": "cysW", "id": "ECS88_2612"}, {"notes": {"original_bigg_ids": ["ECS88_2613"]}, "name": "cysU", "id": "ECS88_2613"}, {"notes": {"original_bigg_ids": ["ECS88_0780"]}, "name": "modB", "id": "ECS88_0780"}, {"notes": {"original_bigg_ids": ["ECS88_0779"]}, "name": "modA", "id": "ECS88_0779"}, {"notes": {"original_bigg_ids": ["ECS88_2611"]}, "name": "cysA", "id": "ECS88_2611"}, {"notes": {"original_bigg_ids": ["ECS88_2614"]}, "name": "cysP", "id": "ECS88_2614"}, {"notes": {"original_bigg_ids": ["ECS88_4367"]}, "name": "sbp", "id": "ECS88_4367"}, {"notes": {"original_bigg_ids": ["ECS88_0781"]}, "name": "modC", "id": "ECS88_0781"}, {"notes": {"original_bigg_ids": ["ECS88_3156"]}, "name": "ygfJ", "id": "ECS88_3156"}, {"notes": {"original_bigg_ids": ["ECS88_0144"]}, "name": "panB", "id": "ECS88_0144"}, {"notes": {"original_bigg_ids": ["ECS88_0010"]}, "name": "mogA", "id": "ECS88_0010"}, {"notes": {"original_bigg_ids": ["ECS88_2695"]}, "name": "pbpC", "id": "ECS88_2695"}, {"notes": {"original_bigg_ids": ["ECS88_1083"]}, "name": "mviN", "id": "ECS88_1083"}, {"notes": {"original_bigg_ids": ["ECS88_0802"]}, "name": "moaE", "id": "ECS88_0802"}, {"notes": {"original_bigg_ids": ["ECS88_0843"]}, "name": "moeB", "id": "ECS88_0843"}, {"notes": {"original_bigg_ids": ["ECS88_1024"]}, "name": "rutE", "id": "ECS88_1024"}, {"notes": {"original_bigg_ids": ["ECS88_0529"]}, "name": "folD", "id": "ECS88_0529"}, {"notes": {"original_bigg_ids": ["ECS88_4397"]}, "name": "metF", "id": "ECS88_4397"}, {"notes": {"original_bigg_ids": ["ECS88_1073"]}, "name": "solA", "id": "ECS88_1073"}, {"notes": {"original_bigg_ids": ["ECS88_2601"]}, "name": "ligA", "id": "ECS88_2601"}, {"notes": {"original_bigg_ids": ["ECS88_4457"]}, "name": "nudC", "id": "ECS88_4457"}, {"notes": {"original_bigg_ids": ["ECS88_1123"]}, "name": "ndh", "id": "ECS88_1123"}, {"notes": {"original_bigg_ids": ["ECS88_2433"]}, "name": "nuoC", "id": "ECS88_2433"}, {"notes": {"original_bigg_ids": ["ECS88_2429"]}, "name": "nuoH", "id": "ECS88_2429"}, {"notes": {"original_bigg_ids": ["ECS88_2432"]}, "name": "nuoE", "id": "ECS88_2432"}, {"notes": {"original_bigg_ids": ["ECS88_2425"]}, "name": "nuoL", "id": "ECS88_2425"}, {"notes": {"original_bigg_ids": ["ECS88_2434"]}, "name": "nuoB", "id": "ECS88_2434"}, {"notes": {"original_bigg_ids": ["ECS88_2430"]}, "name": "nuoG", "id": "ECS88_2430"}, {"notes": {"original_bigg_ids": ["ECS88_2431"]}, "name": "nuoF", "id": "ECS88_2431"}, {"notes": {"original_bigg_ids": ["ECS88_2424"]}, "name": "nuoM", "id": "ECS88_2424"}, {"notes": {"original_bigg_ids": ["ECS88_2435"]}, "name": "nuoA", "id": "ECS88_2435"}, {"notes": {"original_bigg_ids": ["ECS88_2423"]}, "name": "nuoN", "id": "ECS88_2423"}, {"notes": {"original_bigg_ids": ["ECS88_2427"]}, "name": "nuoJ", "id": "ECS88_2427"}, {"notes": {"original_bigg_ids": ["ECS88_2428"]}, "name": "nuoI", "id": "ECS88_2428"}, {"notes": {"original_bigg_ids": ["ECS88_2426"]}, "name": "nuoK", "id": "ECS88_2426"}, {"notes": {"original_bigg_ids": ["ECS88_2801"]}, "name": "yfjB", "id": "ECS88_2801"}, {"notes": {"original_bigg_ids": ["ECS88_3416"]}, "name": "mdaB", "id": "ECS88_3416"}, {"notes": {"original_bigg_ids": ["ECS88_1792"]}, "name": "nadE", "id": "ECS88_1792"}, {"notes": {"original_bigg_ids": ["ECS88_4419"]}, "name": "sthA", "id": "ECS88_4419"}, {"notes": {"original_bigg_ids": ["ECS88_1647"]}, "name": "pntB", "id": "ECS88_1647"}, {"notes": {"original_bigg_ids": ["ECS88_1648"]}, "name": "pntA", "id": "ECS88_1648"}, {"notes": {"original_bigg_ids": ["ECS88_0959"]}, "name": "pncB", "id": "ECS88_0959"}, {"notes": {"original_bigg_ids": ["ECS88_1249"]}, "name": "nhaB", "id": "ECS88_1249"}, {"notes": {"original_bigg_ids": ["ECS88_0020"]}, "name": "nhaA", "id": "ECS88_0020"}, {"notes": {"original_bigg_ids": ["ECS88_2694"]}, "name": "ndk", "id": "ECS88_2694"}, {"notes": {"original_bigg_ids": ["ECS88_0448"]}, "name": "amtB", "id": "ECS88_0448"}, {"notes": {"original_bigg_ids": ["ECS88_2973"]}, "name": "norV", "id": "ECS88_2973"}, {"notes": {"original_bigg_ids": ["ECS88_2974"]}, "name": "norW", "id": "ECS88_2974"}, {"notes": {"original_bigg_ids": ["ECS88_3882"]}, "name": "nikD", "id": "ECS88_3882"}, {"notes": {"original_bigg_ids": ["ECS88_3880"]}, "name": "nikB", "id": "ECS88_3880"}, {"notes": {"original_bigg_ids": ["ECS88_3883"]}, "name": "nikE", "id": "ECS88_3883"}, {"notes": {"original_bigg_ids": ["ECS88_3881"]}, "name": "nikC", "id": "ECS88_3881"}, {"notes": {"original_bigg_ids": ["ECS88_3879"]}, "name": "nikA", "id": "ECS88_3879"}, {"notes": {"original_bigg_ids": ["ECS88_0681"]}, "name": "nadD", "id": "ECS88_0681"}, {"notes": {"original_bigg_ids": ["ECS88_5071"]}, "name": "nadR", "id": "ECS88_5071"}, {"notes": {"original_bigg_ids": ["ECS88_0767"]}, "name": "pnuC", "id": "ECS88_0767"}, {"notes": {"original_bigg_ids": ["ECS88_1820"]}, "name": "pncA", "id": "ECS88_1820"}, {"notes": {"original_bigg_ids": ["ECS88_2056"]}, "name": "cobT", "id": "ECS88_2056"}, {"notes": {"original_bigg_ids": ["ECS88_0111"]}, "name": "nadC", "id": "ECS88_0111"}, {"notes": {"original_bigg_ids": ["ECS88_3758"]}, "name": "nirC", "id": "ECS88_3758"}, {"notes": {"original_bigg_ids": ["ECS88_1293"]}, "name": "narK", "id": "ECS88_1293"}, {"notes": {"original_bigg_ids": ["ECS88_2349"]}, "name": "napC", "id": "ECS88_2349"}, {"notes": {"original_bigg_ids": ["ECS88_2351"]}, "name": "napH", "id": "ECS88_2351"}, {"notes": {"original_bigg_ids": ["ECS88_2352"]}, "name": "napG", "id": "ECS88_2352"}, {"notes": {"original_bigg_ids": ["ECS88_2353"]}, "name": "napA", "id": "ECS88_2353"}, {"notes": {"original_bigg_ids": ["ECS88_2350"]}, "name": "napB", "id": "ECS88_2350"}, {"notes": {"original_bigg_ids": ["ECS88_1294"]}, "name": "narG", "id": "ECS88_1294"}, {"notes": {"original_bigg_ids": ["ECS88_1295"]}, "name": "narH", "id": "ECS88_1295"}, {"notes": {"original_bigg_ids": ["ECS88_1561"]}, "name": "narW", "id": "ECS88_1561"}, {"notes": {"original_bigg_ids": ["ECS88_1560"]}, "name": "narV", "id": "ECS88_1560"}, {"notes": {"original_bigg_ids": ["ECS88_1296"]}, "name": "narJ", "id": "ECS88_1296"}, {"notes": {"original_bigg_ids": ["ECS88_1297"]}, "name": "narI", "id": "ECS88_1297"}, {"notes": {"original_bigg_ids": ["ECS88_2723"]}, "name": "hmp", "id": "ECS88_2723"}, {"notes": {"original_bigg_ids": ["ECS88_2438"]}, "name": "yfbR", "id": "ECS88_2438"}, {"notes": {"original_bigg_ids": ["ECS88_4995"]}, "name": "yjjG", "id": "ECS88_4995"}, {"notes": {"original_bigg_ids": ["ECS88_3014"]}, "name": "surE", "id": "ECS88_3014"}, {"notes": {"original_bigg_ids": ["ECS88_0477"]}, "name": "ushA", "id": "ECS88_0477"}, {"notes": {"original_bigg_ids": ["ECS88_4749"]}, "name": "rsgA", "id": "ECS88_4749"}, {"notes": {"original_bigg_ids": ["ECS88_5077"]}, "name": "yjjX", "id": "ECS88_5077"}, {"notes": {"original_bigg_ids": ["ECS88_1002"]}, "name": "appA", "id": "ECS88_1002"}, {"notes": {"original_bigg_ids": ["ECS88_3049"]}, "name": "mazG", "id": "ECS88_3049"}, {"notes": {"original_bigg_ids": ["ECS88_3236"]}, "name": "yggV", "id": "ECS88_3236"}, {"notes": {"original_bigg_ids": ["ECS88_1811"]}, "name": "nudG", "id": "ECS88_1811"}, {"notes": {"original_bigg_ids": ["ECS88_0171"]}, "name": "dgt", "id": "ECS88_0171"}, {"notes": {"original_bigg_ids": ["ECS88_3757"]}, "name": "nirD", "id": "ECS88_3757"}, {"notes": {"original_bigg_ids": ["ECS88_3756"]}, "name": "nirB", "id": "ECS88_3756"}, {"notes": {"original_bigg_ids": ["ECS88_4565"]}, "name": "nrfC", "id": "ECS88_4565"}, {"notes": {"original_bigg_ids": ["ECS88_4566"]}, "name": "nrfD", "id": "ECS88_4566"}, {"notes": {"original_bigg_ids": ["ECS88_4563"]}, "name": "nrfA", "id": "ECS88_4563"}, {"notes": {"original_bigg_ids": ["ECS88_4564"]}, "name": "nrfB", "id": "ECS88_4564"}, {"notes": {"original_bigg_ids": ["wbbJ"]}, "name": "None", "id": "wbbJ"}, {"notes": {"original_bigg_ids": ["ECS88_0930"]}, "name": "pflA", "id": "ECS88_0930"}, {"notes": {"original_bigg_ids": ["ECS88_2753"]}, "name": "yfiD", "id": "ECS88_2753"}, {"notes": {"original_bigg_ids": ["ECS88_3507"]}, "name": "tdcE", "id": "ECS88_3507"}, {"notes": {"original_bigg_ids": ["ECS88_4841"]}, "name": "argI", "id": "ECS88_4841"}, {"notes": {"original_bigg_ids": ["ECS88_3569"]}, "name": "ispB", "id": "ECS88_3569"}, {"notes": {"original_bigg_ids": ["ECS88_0935"]}, "name": "serC", "id": "ECS88_0935"}, {"notes": {"original_bigg_ids": ["ECS88_0697"]}, "name": "ubiF", "id": "ECS88_0697"}, {"notes": {"original_bigg_ids": ["ECS88_1422"]}, "name": "pyrF", "id": "ECS88_1422"}, {"notes": {"original_bigg_ids": ["ECS88_3187"]}, "name": "ubiH", "id": "ECS88_3187"}, {"notes": {"original_bigg_ids": ["ECS88_4291"]}, "name": "ubiD", "id": "ECS88_4291"}, {"notes": {"original_bigg_ids": ["ECS88_2458"]}, "name": "ubiX", "id": "ECS88_2458"}, {"notes": {"original_bigg_ids": ["ECS88_4285"]}, "name": "ubiB", "id": "ECS88_4285"}, {"notes": {"original_bigg_ids": ["ECS88_3248"]}, "name": "speC", "id": "ECS88_3248"}, {"notes": {"original_bigg_ids": ["ECS88_4056"]}, "name": "pyrE", "id": "ECS88_4056"}, {"notes": {"original_bigg_ids": ["ECS88_2568"]}, "name": "oxc", "id": "ECS88_2568"}, {"notes": {"original_bigg_ids": ["ECS88_1030"]}, "name": "putA", "id": "ECS88_1030"}, {"notes": {"original_bigg_ids": ["ECS88_0381"]}, "name": "proC", "id": "ECS88_0381"}, {"notes": {"original_bigg_ids": ["ECS88_0143"]}, "name": "panC", "id": "ECS88_0143"}, {"notes": {"original_bigg_ids": ["ECS88_1418"]}, "name": "pgpB", "id": "ECS88_1418"}, {"notes": {"original_bigg_ids": ["ECS88_0090"]}, "name": "mraY", "id": "ECS88_0090"}, {"notes": {"original_bigg_ids": ["ECS88_3026"]}, "name": "cysH", "id": "ECS88_3026"}, {"notes": {"original_bigg_ids": ["ECS88_1577"]}, "name": "dos", "id": "ECS88_1577"}, {"notes": {"original_bigg_ids": ["ECS88_0123"]}, "name": "aceE", "id": "ECS88_0123"}, {"notes": {"original_bigg_ids": ["ECS88_0124"]}, "name": "aceF", "id": "ECS88_0124"}, {"notes": {"original_bigg_ids": ["ECS88_1686"]}, "name": "pdxH", "id": "ECS88_1686"}, {"notes": {"original_bigg_ids": ["ECS88_2737"]}, "name": "pdxJ", "id": "ECS88_2737"}, {"notes": {"original_bigg_ids": ["ECS88_0057"]}, "name": "pdxA", "id": "ECS88_0057"}, {"notes": {"original_bigg_ids": ["ECS88_0782"]}, "name": "ybhA", "id": "ECS88_0782"}, {"notes": {"original_bigg_ids": ["ECS88_2468"]}, "name": "pdxB", "id": "ECS88_2468"}, {"notes": {"original_bigg_ids": ["ECS88_3965"]}, "name": "eptB", "id": "ECS88_3965"}, {"notes": {"original_bigg_ids": ["ECS88_1775"]}, "name": "pfkB", "id": "ECS88_1775"}, {"notes": {"original_bigg_ids": ["ECS88_4366"]}, "name": "pfkA", "id": "ECS88_4366"}, {"notes": {"original_bigg_ids": ["ECS88_4407"]}, "name": "pflC", "id": "ECS88_4407"}, {"notes": {"original_bigg_ids": ["ECS88_4406"]}, "name": "pflD", "id": "ECS88_4406"}, {"notes": {"original_bigg_ids": ["ECS88_3558"]}, "name": "glmM", "id": "ECS88_3558"}, {"notes": {"original_bigg_ids": ["ECS88_3192"]}, "name": "serA", "id": "ECS88_3192"}, {"notes": {"original_bigg_ids": ["ECS88_4498"]}, "name": "pgi", "id": "ECS88_4498"}, {"notes": {"original_bigg_ids": ["ECS88_3202"]}, "name": "pgk", "id": "ECS88_3202"}, {"notes": {"original_bigg_ids": ["ECS88_0783"]}, "name": "pgl", "id": "ECS88_0783"}, {"notes": {"original_bigg_ids": ["ECS88_3770"]}, "name": "gph", "id": "ECS88_3770"}, {"notes": {"original_bigg_ids": ["ECS88_0771"]}, "name": "gpmA", "id": "ECS88_0771"}, {"notes": {"original_bigg_ids": ["ECS88_5078"]}, "name": "ytjC", "id": "ECS88_5078"}, {"notes": {"original_bigg_ids": ["ECS88_4029"]}, "name": "gpmI", "id": "ECS88_4029"}, {"notes": {"original_bigg_ids": ["ECS88_0725"]}, "name": "pgm", "id": "ECS88_0725"}, {"notes": {"original_bigg_ids": ["ECS88_2957"]}, "name": "yqaB", "id": "ECS88_2957"}, {"notes": {"original_bigg_ids": ["ECS88_0413"]}, "name": "pgpA", "id": "ECS88_0413"}, {"notes": {"original_bigg_ids": ["ECS88_1966"]}, "name": "pgsA", "id": "ECS88_1966"}, {"notes": {"original_bigg_ids": ["ECS88_2348"]}, "name": "ccmA", "id": "ECS88_2348"}, {"notes": {"original_bigg_ids": ["ECS88_2347"]}, "name": "ccmB", "id": "ECS88_2347"}, {"notes": {"original_bigg_ids": ["ECS88_2346"]}, "name": "ccmC", "id": "ECS88_2346"}, {"notes": {"original_bigg_ids": ["ECS88_2345"]}, "name": "ccmD", "id": "ECS88_2345"}, {"notes": {"original_bigg_ids": ["ECS88_2344"]}, "name": "ccmE", "id": "ECS88_2344"}, {"notes": {"original_bigg_ids": ["ECS88_1764"]}, "name": "pheT", "id": "ECS88_1764"}, {"notes": {"original_bigg_ids": ["ECS88_1765"]}, "name": "pheS", "id": "ECS88_1765"}, {"notes": {"original_bigg_ids": ["ECS88_1565"]}, "name": "yddG", "id": "ECS88_1565"}, {"notes": {"original_bigg_ids": ["ECS88_0613"]}, "name": "pheP", "id": "ECS88_0613"}, {"notes": {"original_bigg_ids": ["ECS88_3369"]}, "name": "pitB", "id": "ECS88_3369"}, {"notes": {"original_bigg_ids": ["ECS88_4148"]}, "name": "pstA", "id": "ECS88_4148"}, {"notes": {"original_bigg_ids": ["ECS88_4147"]}, "name": "pstB", "id": "ECS88_4147"}, {"notes": {"original_bigg_ids": ["ECS88_4149"]}, "name": "pstC", "id": "ECS88_4149"}, {"notes": {"original_bigg_ids": ["ECS88_4150"]}, "name": "pstS", "id": "ECS88_4150"}, {"notes": {"original_bigg_ids": ["ECS88_4247"]}, "name": "pldA", "id": "ECS88_4247"}, {"notes": {"original_bigg_ids": ["ECS88_2145"]}, "name": "cpsG", "id": "ECS88_2145"}, {"notes": {"original_bigg_ids": ["ECS88_3799"]}, "name": "bioH", "id": "ECS88_3799"}, {"notes": {"original_bigg_ids": ["ECS88_4438"]}, "name": "coaA", "id": "ECS88_4438"}, {"notes": {"original_bigg_ids": ["ECS88_3643"]}, "name": "panF", "id": "ECS88_3643"}, {"notes": {"original_bigg_ids": ["ECS88_1026"]}, "name": "rutC", "id": "ECS88_1026"}, {"notes": {"original_bigg_ids": ["ECS88_1493"]}, "name": "ydbK", "id": "ECS88_1493"}, {"notes": {"original_bigg_ids": ["ECS88_0892"]}, "name": "poxB", "id": "ECS88_0892"}, {"notes": {"original_bigg_ids": ["ECS88_2674"]}, "name": "ppx", "id": "ECS88_2674"}, {"notes": {"original_bigg_ids": ["ECS88_4816"]}, "name": "ppa", "id": "ECS88_4816"}, {"notes": {"original_bigg_ids": ["ECS88_1032"]}, "name": "putP", "id": "ECS88_1032"}, {"notes": {"original_bigg_ids": ["ECS88_0366"]}, "name": "hemB", "id": "ECS88_0366"}, {"notes": {"original_bigg_ids": ["ECS88_4411"]}, "name": "ppc", "id": "ECS88_4411"}, {"notes": {"original_bigg_ids": ["ECS88_4053"]}, "name": "dfp", "id": "ECS88_4053"}, {"notes": {"original_bigg_ids": ["ECS88_3790"]}, "name": "pck", "id": "ECS88_3790"}, {"notes": {"original_bigg_ids": ["ECS88_2673"]}, "name": "ppk", "id": "ECS88_2673"}, {"notes": {"original_bigg_ids": ["ECS88_5064"]}, "name": "deoB", "id": "ECS88_5064"}, {"notes": {"original_bigg_ids": ["ECS88_3765"]}, "name": "yhfW", "id": "ECS88_3765"}, {"notes": {"original_bigg_ids": ["ECS88_4298"]}, "name": "hemG", "id": "ECS88_4298"}, {"notes": {"original_bigg_ids": ["ECS88_2712"]}, "name": "hcaT", "id": "ECS88_2712"}, {"notes": {"original_bigg_ids": ["ECS88_1753"]}, "name": "pps", "id": "ECS88_1753"}, {"notes": {"original_bigg_ids": ["ECS88_0377"]}, "name": "phoA", "id": "ECS88_0377"}, {"notes": {"original_bigg_ids": ["ECS88_4466"]}, "name": "purD", "id": "ECS88_4466"}, {"notes": {"original_bigg_ids": ["ECS88_2671"]}, "name": "purM", "id": "ECS88_2671"}, {"notes": {"original_bigg_ids": ["ECS88_2125"]}, "name": "hisI", "id": "ECS88_2125"}, {"notes": {"original_bigg_ids": ["ECS88_2658"]}, "name": "purC", "id": "ECS88_2658"}, {"notes": {"original_bigg_ids": ["ECS88_2729"]}, "name": "purL", "id": "ECS88_2729"}, {"notes": {"original_bigg_ids": ["ECS88_2123"]}, "name": "hisA", "id": "ECS88_2123"}, {"notes": {"original_bigg_ids": ["ECS88_0206"]}, "name": "proS", "id": "ECS88_0206"}, {"notes": {"original_bigg_ids": ["ECS88_1275"]}, "name": "prsA", "id": "ECS88_1275"}, {"notes": {"original_bigg_ids": ["ECS88_0936"]}, "name": "aroA", "id": "ECS88_0936"}, {"notes": {"original_bigg_ids": ["ECS88_4748"]}, "name": "psd", "id": "ECS88_4748"}, {"notes": {"original_bigg_ids": ["ECS88_5069"]}, "name": "serB", "id": "ECS88_5069"}, {"notes": {"original_bigg_ids": ["ECS88_2760"]}, "name": "pssA", "id": "ECS88_2760"}, {"notes": {"original_bigg_ids": ["ECS88_2444"]}, "name": "pta", "id": "ECS88_2444"}, {"notes": {"original_bigg_ids": ["ECS88_2637"]}, "name": "eutI", "id": "ECS88_2637"}, {"notes": {"original_bigg_ids": ["ECS88_4048"]}, "name": "coaD", "id": "ECS88_4048"}, {"notes": {"original_bigg_ids": ["ECS88_0726"]}, "name": "potE", "id": "ECS88_0726"}, {"notes": {"original_bigg_ids": ["ECS88_3470"]}, "name": "ygjG", "id": "ECS88_3470"}, {"notes": {"original_bigg_ids": ["ECS88_1537"]}, "name": "ydcV", "id": "ECS88_1537"}, {"notes": {"original_bigg_ids": ["ECS88_0872"]}, "name": "potG", "id": "ECS88_0872"}, {"notes": {"original_bigg_ids": ["ECS88_1534"]}, "name": "ydcT", "id": "ECS88_1534"}, {"notes": {"original_bigg_ids": ["ECS88_1137"]}, "name": "potD", "id": "ECS88_1137"}, {"notes": {"original_bigg_ids": ["ECS88_1536"]}, "name": "ydcU", "id": "ECS88_1536"}, {"notes": {"original_bigg_ids": ["ECS88_1138"]}, "name": "potC", "id": "ECS88_1138"}, {"notes": {"original_bigg_ids": ["ECS88_0874"]}, "name": "potI", "id": "ECS88_0874"}, {"notes": {"original_bigg_ids": ["ECS88_1139"]}, "name": "potB", "id": "ECS88_1139"}, {"notes": {"original_bigg_ids": ["ECS88_1140"]}, "name": "potA", "id": "ECS88_1140"}, {"notes": {"original_bigg_ids": ["ECS88_0873"]}, "name": "potH", "id": "ECS88_0873"}, {"notes": {"original_bigg_ids": ["ECS88_1533"]}, "name": "ydcS", "id": "ECS88_1533"}, {"notes": {"original_bigg_ids": ["ECS88_0871"]}, "name": "potF", "id": "ECS88_0871"}, {"notes": {"original_bigg_ids": ["ECS88_2596"]}, "name": "xapA", "id": "ECS88_2596"}, {"notes": {"original_bigg_ids": ["ECS88_1684"]}, "name": "pdxY", "id": "ECS88_1684"}, {"notes": {"original_bigg_ids": ["ECS88_4254"]}, "name": "yigL", "id": "ECS88_4254"}, {"notes": {"original_bigg_ids": ["ECS88_1726"]}, "name": "pykF", "id": "ECS88_1726"}, {"notes": {"original_bigg_ids": ["ECS88_1911"]}, "name": "pykA", "id": "ECS88_1911"}, {"notes": {"original_bigg_ids": ["ECS88_4275"]}, "name": "udp", "id": "ECS88_4275"}, {"notes": {"original_bigg_ids": ["ECS88_1028"]}, "name": "rutA", "id": "ECS88_1028"}, {"notes": {"original_bigg_ids": ["ECS88_1023"]}, "name": "rutF", "id": "ECS88_1023"}, {"notes": {"original_bigg_ids": ["ECS88_3417"]}, "name": "ygiN", "id": "ECS88_3417"}, {"notes": {"original_bigg_ids": ["ECS88_1742"]}, "name": "ydiB", "id": "ECS88_1742"}, {"notes": {"original_bigg_ids": ["ECS88_0766"]}, "name": "nadA", "id": "ECS88_0766"}, {"notes": {"original_bigg_ids": ["ECS88_4595"]}, "name": "phnN", "id": "ECS88_4595"}, {"notes": {"original_bigg_ids": ["ECS88_1711"]}, "name": "ribC", "id": "ECS88_1711"}, {"notes": {"original_bigg_ids": ["ECS88_0410"]}, "name": "ribE", "id": "ECS88_0410"}, {"notes": {"original_bigg_ids": ["ECS88_4174"]}, "name": "rbsK", "id": "ECS88_4174"}, {"notes": {"original_bigg_ids": ["ECS88_0066"]}, "name": "araB", "id": "ECS88_0066"}, {"notes": {"original_bigg_ids": ["ECS88_4784"]}, "name": "ulaF", "id": "ECS88_4784"}, {"notes": {"original_bigg_ids": ["ECS88_4003"]}, "name": "sgbE", "id": "ECS88_4003"}, {"notes": {"original_bigg_ids": 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{"notes": {"original_bigg_ids": ["ECS88_4828"]}, "name": "nrdD", "id": "ECS88_4828"}, {"notes": {"original_bigg_ids": ["ECS88_4827"]}, "name": "nrdG", "id": "ECS88_4827"}, {"notes": {"original_bigg_ids": ["ECS88_4912"]}, "name": "sgcE", "id": "ECS88_4912"}, {"notes": {"original_bigg_ids": ["ECS88_3771"]}, "name": "rpe", "id": "ECS88_3771"}, {"notes": {"original_bigg_ids": ["ECS88_3193"]}, "name": "rpiA", "id": "ECS88_3193"}, {"notes": {"original_bigg_ids": ["ECS88_0680"]}, "name": "phpB", "id": "ECS88_0680"}, {"notes": {"original_bigg_ids": ["ECS88_1730"]}, "name": "sufS", "id": "ECS88_1730"}, {"notes": {"original_bigg_ids": ["ECS88_1733"]}, "name": "sufB", "id": "ECS88_1733"}, {"notes": {"original_bigg_ids": ["ECS88_1729"]}, "name": "sufE", "id": "ECS88_1729"}, {"notes": {"original_bigg_ids": ["ECS88_1732"]}, "name": "sufC", "id": "ECS88_1732"}, {"notes": {"original_bigg_ids": ["ECS88_1731"]}, "name": "sufD", "id": "ECS88_1731"}, {"notes": {"original_bigg_ids": ["ECS88_1734"]}, "name": "sufA", "id": "ECS88_1734"}, {"notes": {"original_bigg_ids": ["ECS88_0259"]}, "name": "lpcA", "id": "ECS88_0259"}, {"notes": {"original_bigg_ids": ["ECS88_1797"]}, "name": "astB", "id": "ECS88_1797"}, {"notes": {"original_bigg_ids": ["ECS88_3023"]}, "name": "cysD", "id": "ECS88_3023"}, {"notes": {"original_bigg_ids": ["ECS88_3022"]}, "name": "cysN", "id": "ECS88_3022"}, {"notes": {"original_bigg_ids": ["ECS88_2968"]}, "name": "srlD", "id": "ECS88_2968"}, {"notes": {"original_bigg_ids": ["ECS88_2967"]}, "name": "srlB", "id": "ECS88_2967"}, {"notes": {"original_bigg_ids": ["ECS88_2966"]}, "name": "srlE", "id": "ECS88_2966"}, {"notes": {"original_bigg_ids": ["ECS88_2965"]}, "name": "srlA", "id": "ECS88_2965"}, {"notes": {"original_bigg_ids": ["ECS88_2652"]}, "name": "dapE", "id": "ECS88_2652"}, {"notes": {"original_bigg_ids": ["ECS88_4008"]}, "name": "selA", "id": "ECS88_4008"}, {"notes": {"original_bigg_ids": ["ECS88_1814"]}, "name": "selD", "id": "ECS88_1814"}, {"notes": {"original_bigg_ids": ["ECS88_2415"]}, "name": "menD", "id": "ECS88_2415"}, {"notes": {"original_bigg_ids": ["ECS88_0625"]}, "name": "entF", "id": "ECS88_0625"}, {"notes": {"original_bigg_ids": ["ECS88_4024"]}, "name": "cysE", "id": "ECS88_4024"}, {"notes": {"original_bigg_ids": ["ECS88_2560"]}, "name": "dsdA", "id": "ECS88_2560"}, {"notes": {"original_bigg_ids": ["ECS88_1866"]}, "name": "sdaA", "id": "ECS88_1866"}, {"notes": {"original_bigg_ids": ["ECS88_3505"]}, "name": "tdcG", "id": "ECS88_3505"}, {"notes": {"original_bigg_ids": ["ECS88_0924"]}, "name": "serS", "id": "ECS88_0924"}, {"notes": {"original_bigg_ids": ["ECS88_3509"]}, "name": "tdcC", "id": "ECS88_3509"}, {"notes": {"original_bigg_ids": ["ECS88_3065"]}, "name": "sdaC", "id": "ECS88_3065"}, {"notes": {"original_bigg_ids": ["ECS88_3485"]}, "name": "sstT", "id": "ECS88_3485"}, {"notes": {"original_bigg_ids": ["ECS88_0355"]}, "name": "frmB", "id": "ECS88_0355"}, {"notes": {"original_bigg_ids": ["ECS88_2302"]}, "name": "frmC", "id": "ECS88_2302"}, {"notes": {"original_bigg_ids": ["ECS88_1796"]}, "name": "astE", "id": "ECS88_1796"}, {"notes": {"original_bigg_ids": ["ECS88_1798"]}, "name": "astD", "id": "ECS88_1798"}, {"notes": {"original_bigg_ids": ["ECS88_2414"]}, "name": "yfbB", "id": "ECS88_2414"}, {"notes": {"original_bigg_ids": ["ECS88_3759"]}, "name": "cysG", "id": "ECS88_3759"}, {"notes": {"original_bigg_ids": ["ECS88_3669"]}, "name": "aroE", "id": "ECS88_3669"}, {"notes": {"original_bigg_ids": ["ECS88_3775"]}, "name": "aroK", "id": "ECS88_3775"}, {"notes": {"original_bigg_ids": ["ECS88_0383"]}, "name": "aroL", "id": "ECS88_0383"}, {"notes": {"original_bigg_ids": ["ECS88_4390"]}, "name": "metB", "id": "ECS88_4390"}, {"notes": {"original_bigg_ids": ["ECS88_2049"]}, "name": "shiA", "id": "ECS88_2049"}, {"notes": {"original_bigg_ids": ["ECS88_1274"]}, "name": "ychM", "id": "ECS88_1274"}, {"notes": {"original_bigg_ids": ["ECS88_1629"]}, "name": "speG", "id": "ECS88_1629"}, {"notes": {"original_bigg_ids": ["ECS88_1645"]}, "name": "mdtJ", "id": "ECS88_1645"}, {"notes": {"original_bigg_ids": ["ECS88_1644"]}, "name": "mdtI", "id": "ECS88_1644"}, {"notes": {"original_bigg_ids": ["ECS88_4358"]}, "name": "sodA", "id": "ECS88_4358"}, {"notes": {"original_bigg_ids": ["ECS88_1705"]}, "name": "sodB", "id": "ECS88_1705"}, {"notes": {"original_bigg_ids": ["ECS88_1694"]}, "name": "sodC", "id": "ECS88_1694"}, {"notes": {"original_bigg_ids": ["ECS88_1602"]}, "name": "yneI", "id": "ECS88_1602"}, {"notes": {"original_bigg_ids": ["ECS88_2925"]}, "name": "gabD", "id": "ECS88_2925"}, {"notes": {"original_bigg_ids": ["ECS88_2411"]}, "name": "menE", "id": "ECS88_2411"}, {"notes": {"original_bigg_ids": ["ECS88_2412"]}, "name": "menC", "id": "ECS88_2412"}, {"notes": {"original_bigg_ids": ["ECS88_0748"]}, "name": "sdhD", "id": "ECS88_0748"}, {"notes": {"original_bigg_ids": ["ECS88_0750"]}, "name": "sdhB", "id": "ECS88_0750"}, {"notes": {"original_bigg_ids": ["ECS88_0747"]}, "name": "sdhC", "id": "ECS88_0747"}, {"notes": {"original_bigg_ids": ["ECS88_0749"]}, "name": "sdhA", "id": "ECS88_0749"}, {"notes": {"original_bigg_ids": ["ECS88_0754"]}, "name": "sucD", "id": "ECS88_0754"}, {"notes": {"original_bigg_ids": ["ECS88_0753"]}, "name": "sucC", "id": "ECS88_0753"}, {"notes": {"original_bigg_ids": ["ECS88_1598"]}, "name": "uxaB", "id": "ECS88_1598"}, {"notes": {"original_bigg_ids": ["ECS88_0009"]}, "name": "talB", "id": "ECS88_0009"}, {"notes": {"original_bigg_ids": ["ECS88_2643"]}, "name": "talA", "id": "ECS88_2643"}, {"notes": {"original_bigg_ids": ["ECS88_3460"]}, "name": "ttdB", "id": "ECS88_3460"}, {"notes": {"original_bigg_ids": ["ECS88_3459"]}, "name": "ttdA", "id": "ECS88_3459"}, {"notes": {"original_bigg_ids": ["ECS88_3461"]}, "name": "ygjE", "id": "ECS88_3461"}, {"notes": {"original_bigg_ids": ["ECS88_0365"]}, "name": "tauD", "id": "ECS88_0365"}, {"notes": {"original_bigg_ids": ["ECS88_4212"]}, "name": "rffC", "id": "ECS88_4212"}, {"notes": {"original_bigg_ids": ["ECS88_4213"]}, "name": "rffA", "id": "ECS88_4213"}, {"notes": {"original_bigg_ids": ["ECS88_2138"]}, "name": "rmlB", "id": "ECS88_2138"}, {"notes": {"original_bigg_ids": ["ECS88_4210"]}, "name": "rffG", "id": "ECS88_4210"}, {"notes": {"original_bigg_ids": ["ECS88_0943"]}, "name": "lpxK", "id": "ECS88_0943"}, {"notes": {"original_bigg_ids": ["ECS88_3518"]}, "name": "kbaZ", "id": "ECS88_3518"}, {"notes": {"original_bigg_ids": ["ECS88_2238"]}, "name": "gatY", "id": "ECS88_2238"}, {"notes": {"original_bigg_ids": ["ECS88_2237"]}, "name": "gatZ", "id": "ECS88_2237"}, {"notes": {"original_bigg_ids": ["ECS88_3525"]}, "name": "kbaY", "id": "ECS88_3525"}, {"notes": {"original_bigg_ids": ["ECS88_0175"]}, "name": "dapD", "id": "ECS88_0175"}, {"notes": {"original_bigg_ids": ["ECS88_2662"]}, "name": "bcp", "id": "ECS88_2662"}, {"notes": {"original_bigg_ids": ["ECS88_0072"]}, "name": "thiP", "id": "ECS88_0072"}, {"notes": {"original_bigg_ids": ["ECS88_0071"]}, "name": "thiQ", "id": "ECS88_0071"}, {"notes": {"original_bigg_ids": ["ECS88_0073"]}, "name": "tbpA", "id": "ECS88_0073"}, {"notes": {"original_bigg_ids": ["ECS88_4033"]}, "name": "tdh", "id": "ECS88_4033"}, {"notes": {"original_bigg_ids": ["ECS88_3510"]}, "name": "tdcB", "id": "ECS88_3510"}, {"notes": {"original_bigg_ids": ["ECS88_4195"]}, "name": "ilvA", "id": "ECS88_4195"}, {"notes": {"original_bigg_ids": ["ECS88_1769"]}, "name": "thrS", "id": "ECS88_1769"}, {"notes": {"original_bigg_ids": ["ECS88_4251"]}, "name": "rhtC", "id": "ECS88_4251"}, {"notes": {"original_bigg_ids": ["ECS88_4453"]}, "name": "thiF", "id": "ECS88_4453"}, {"notes": {"original_bigg_ids": ["ECS88_4450"]}, "name": "thiH", "id": "ECS88_4450"}, {"notes": {"original_bigg_ids": ["ECS88_0419"]}, "name": "thiI", "id": "ECS88_0419"}, {"notes": {"original_bigg_ids": ["ECS88_4452"]}, "name": "thiS", "id": "ECS88_4452"}, {"notes": {"original_bigg_ids": ["ECS88_2644"]}, "name": "tktB", "id": "ECS88_2644"}, {"notes": {"original_bigg_ids": ["ECS88_1011"]}, "name": "torC", "id": "ECS88_1011"}, {"notes": {"original_bigg_ids": ["ECS88_1012"]}, "name": "torA", "id": "ECS88_1012"}, {"notes": {"original_bigg_ids": ["ECS88_3122"]}, "name": "thyA", "id": "ECS88_3122"}, {"notes": {"original_bigg_ids": ["ECS88_1120"]}, "name": "ycfN", "id": "ECS88_1120"}, {"notes": {"original_bigg_ids": ["ECS88_0412"]}, "name": "thiL", "id": "ECS88_0412"}, {"notes": {"original_bigg_ids": ["ECS88_4454"]}, "name": "thiE", "id": "ECS88_4454"}, {"notes": {"original_bigg_ids": ["ECS88_4369"]}, "name": "tpiA", "id": "ECS88_4369"}, {"notes": {"original_bigg_ids": ["ECS88_0654"]}, "name": "citG", "id": "ECS88_0654"}, {"notes": {"original_bigg_ids": ["ECS88_0917"]}, "name": "trxB", "id": "ECS88_0917"}, {"notes": {"original_bigg_ids": ["ECS88_4829"]}, "name": "treC", "id": "ECS88_4829"}, {"notes": {"original_bigg_ids": ["ECS88_1952"]}, "name": "otsB", "id": "ECS88_1952"}, {"notes": {"original_bigg_ids": ["ECS88_1951"]}, "name": "otsA", "id": "ECS88_1951"}, {"notes": {"original_bigg_ids": ["ECS88_3932"]}, "name": "treF", "id": "ECS88_3932"}, {"notes": {"original_bigg_ids": ["ECS88_1265"]}, "name": "treA", "id": "ECS88_1265"}, {"notes": {"original_bigg_ids": ["ECS88_4830"]}, "name": "treB", "id": "ECS88_4830"}, {"notes": {"original_bigg_ids": ["ECS88_1396"]}, "name": "trpB", "id": "ECS88_1396"}, {"notes": {"original_bigg_ids": ["ECS88_1395"]}, "name": "trpA", "id": "ECS88_1395"}, {"notes": {"original_bigg_ids": ["ECS88_3769"]}, "name": "trpS", "id": "ECS88_3769"}, {"notes": {"original_bigg_ids": ["ECS88_4132"]}, "name": "tnaB", "id": "ECS88_4132"}, {"notes": {"original_bigg_ids": ["ECS88_3513"]}, "name": "garR", "id": "ECS88_3513"}, {"notes": {"original_bigg_ids": ["ECS88_0508"]}, "name": "glxR", "id": "ECS88_0508"}, {"notes": {"original_bigg_ids": ["ECS88_4451"]}, "name": "thiG", "id": "ECS88_4451"}, {"notes": {"original_bigg_ids": ["ECS88_1685"]}, "name": "tyrS", "id": "ECS88_1685"}, {"notes": {"original_bigg_ids": ["ECS88_1963"]}, "name": "tyrP", "id": "ECS88_1963"}, {"notes": {"original_bigg_ids": ["ECS88_0190"]}, "name": "lpxD", "id": "ECS88_0190"}, {"notes": {"original_bigg_ids": ["ECS88_0088"]}, "name": "murE", "id": "ECS88_0088"}, {"notes": {"original_bigg_ids": ["ECS88_4209"]}, "name": "rffD", "id": "ECS88_4209"}, {"notes": {"original_bigg_ids": ["ECS88_4208"]}, "name": "rffE", "id": "ECS88_4208"}, {"notes": {"original_bigg_ids": ["ECS88_0192"]}, "name": "lpxA", "id": "ECS88_0192"}, {"notes": {"original_bigg_ids": ["ECS88_3571"]}, "name": "murA", "id": "ECS88_3571"}, {"notes": {"original_bigg_ids": ["ECS88_0093"]}, "name": "murG", "id": "ECS88_0093"}, {"notes": {"original_bigg_ids": ["ECS88_0091"]}, "name": "murD", "id": "ECS88_0091"}, {"notes": {"original_bigg_ids": ["ECS88_0094"]}, "name": "murC", "id": "ECS88_0094"}, {"notes": {"original_bigg_ids": ["ECS88_4436"]}, "name": "murB", "id": "ECS88_4436"}, {"notes": {"original_bigg_ids": ["ECS88_0858"]}, "name": "ybjG", "id": "ECS88_0858"}, {"notes": {"original_bigg_ids": ["ECS88_3455"]}, "name": "bacA", "id": "ECS88_3455"}, {"notes": {"original_bigg_ids": ["ECS88_0184"]}, "name": "ispU", "id": "ECS88_0184"}, {"notes": {"original_bigg_ids": ["ECS88_0775"]}, "name": "galE", "id": "ECS88_0775"}, {"notes": {"original_bigg_ids": ["ECS88_2127"]}, "name": "ugd", "id": "ECS88_2127"}, {"notes": {"original_bigg_ids": ["ECS88_2404"]}, "name": "yfbG", "id": "ECS88_2404"}, {"notes": {"original_bigg_ids": ["ECS88_2402"]}, "name": "yfbE", "id": "ECS88_2402"}, {"notes": {"original_bigg_ids": ["ECS88_0774"]}, "name": "galT", "id": "ECS88_0774"}, {"notes": {"original_bigg_ids": ["ECS88_0504"]}, "name": "allA", "id": "ECS88_0504"}, {"notes": {"original_bigg_ids": ["ECS88_0089"]}, "name": "murF", "id": "ECS88_0089"}, {"notes": {"original_bigg_ids": ["ECS88_0100"]}, "name": "lpxC", "id": "ECS88_0100"}, {"notes": {"original_bigg_ids": ["ECS88_2408"]}, "name": "yfbW", "id": "ECS88_2408"}, {"notes": {"original_bigg_ids": ["ECS88_2409"]}, "name": "yfbJ", "id": "ECS88_2409"}, {"notes": {"original_bigg_ids": ["ECS88_4823"]}, "name": "mpl", "id": "ECS88_4823"}, {"notes": {"original_bigg_ids": ["ECS88_0181"]}, "name": "pyrH", "id": "ECS88_0181"}, {"notes": {"original_bigg_ids": ["ECS88_2405"]}, "name": "yfbH", "id": "ECS88_2405"}, {"notes": {"original_bigg_ids": ["ECS88_2403"]}, "name": "yfbF", "id": "ECS88_2403"}, {"notes": {"original_bigg_ids": ["ECS88_4225"]}, "name": "hemX", "id": "ECS88_4225"}, {"notes": {"original_bigg_ids": ["ECS88_4226"]}, "name": "hemD", "id": "ECS88_4226"}, {"notes": {"original_bigg_ids": ["ECS88_4458"]}, "name": "hemE", "id": "ECS88_4458"}, {"notes": {"original_bigg_ids": ["ECS88_2669"]}, "name": "upp", "id": "ECS88_2669"}, {"notes": {"original_bigg_ids": ["ECS88_1027"]}, "name": "rutB", "id": "ECS88_1027"}, {"notes": {"original_bigg_ids": ["ECS88_2668"]}, "name": "uraA", "id": "ECS88_2668"}, {"notes": {"original_bigg_ids": ["ECS88_0516"]}, "name": "allD", "id": "ECS88_0516"}, {"notes": {"original_bigg_ids": ["ECS88_0524"]}, "name": "lpxH", 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{"name": "Diphosphate", "notes": {"original_bigg_ids": ["ppi_c"]}, "charge": -3, "formula": "HO7P2", "compartment": "c", "id": "ppi_c"}, {"name": "Two disacharide linked murein units, tripeptide crosslinked tetrapeptide (A2pm->D-ala) (middle of chain)", "notes": {"original_bigg_ids": ["murein3px4p_p"]}, "charge": -4, "formula": "C71H107N13O38", "compartment": "p", "id": "murein3px4p_p"}, {"name": "Ammonium", "notes": {"original_bigg_ids": ["nh4_c"]}, "charge": 1, "formula": "H4N", "compartment": "c", "id": "nh4_c"}, {"name": "Two linked disacharide tetrapeptide murein units (uncrosslinked, middle of chain)", "notes": {"original_bigg_ids": ["murein4p4p_p"]}, "charge": -4, "formula": "C74H114N14O40", "compartment": "p", "id": "murein4p4p_p"}, {"name": "Riboflavin", "notes": {"original_bigg_ids": ["ribflv_c"]}, "charge": 0, "formula": "C17H20N4O6", "compartment": "c", "id": "ribflv_c"}, {"name": "Adenosylcobalamin", "notes": {"original_bigg_ids": ["adocbl_c"]}, "charge": 0, "formula": "C72H100CoN18O17P", "compartment": "c", "id": "adocbl_c"}, {"name": "2-Demethylmenaquinol 8", "notes": {"original_bigg_ids": ["2dmmql8_c"]}, "charge": 0, "formula": "C50H72O2", "compartment": "c", "id": "2dmmql8_c"}, {"name": "Cardiolipin (tetrahexadec-9-enoyl, n-C16:1)", "notes": {"original_bigg_ids": ["clpn161_p"]}, "charge": -2, "formula": "C73H132O17P2", "compartment": "p", "id": "clpn161_p"}, {"name": "CTP", "notes": {"original_bigg_ids": ["ctp_c"]}, "charge": -4, "formula": "C9H12N3O14P3", "compartment": "c", "id": "ctp_c"}, {"name": "Chorismate", "notes": {"original_bigg_ids": ["chor_c"]}, "charge": -2, "formula": "C10H8O6", "compartment": "c", "id": "chor_c"}, {"name": "Fe2+", "notes": {"original_bigg_ids": ["fe2_c"]}, "charge": 2, "formula": "Fe", "compartment": "c", "id": "fe2_c"}, {"name": "Core oligosaccharide lipid A", "notes": {"original_bigg_ids": ["colipa_e"]}, "charge": -11, "formula": "C176H303N2O100P4", "compartment": "e", "id": "colipa_e"}, {"name": "Glycine", "notes": {"original_bigg_ids": ["gly_c"]}, "charge": 0, "formula": "C2H5NO2", "compartment": "c", "id": "gly_c"}, {"name": "Phosphate", "notes": {"original_bigg_ids": ["pi_c"]}, "charge": -2, "formula": "HO4P", "compartment": "c", "id": "pi_c"}, {"name": "Phosphatidylethanolamine (dihexadec-9enoyl, n-C16:1)", "notes": {"original_bigg_ids": ["pe161_p"]}, "charge": 0, "formula": "C37H70N1O8P1", "compartment": "p", "id": "pe161_p"}, {"name": "Menaquinol 8", "notes": {"original_bigg_ids": ["mql8_c"]}, "charge": 0, "formula": "C51H74O2", "compartment": "c", "id": "mql8_c"}, {"name": "L-Proline", "notes": {"original_bigg_ids": ["pro_DASH_L_c"]}, "charge": 0, "formula": "C5H9NO2", "compartment": "c", "id": "pro__L_c"}, {"name": "Two disacharide linked murein units, tetrapeptide corsslinked tetrapeptide (A2pm->D-ala) (middle of chain)", "notes": {"original_bigg_ids": ["murein4px4p_p"]}, "charge": -4, "formula": "C74H112N14O39", "compartment": "p", "id": "murein4px4p_p"}, {"name": "Magnesium", "notes": {"original_bigg_ids": ["mg2_c"]}, "charge": 2, "formula": "Mg", "compartment": "c", "id": "mg2_c"}, {"name": "Three disacharide linked murein units (tetrapeptide crosslinked tetrapeptide (A2pm->D-ala) & tetrapeptide corsslinked tetrapeptide (A2pm->D-ala)) (middle of chain)", "notes": {"original_bigg_ids": ["murein4px4px4p_p"]}, "charge": -6, "formula": "C111H167N21O58", "compartment": "p", "id": "murein4px4px4p_p"}, {"name": "Phosphatidylethanolamine (dioctadec-11-enoyl, n-C18:1)", "notes": {"original_bigg_ids": ["pe181_p"]}, "charge": 0, "formula": "C41H78N1O8P1", "compartment": "p", "id": "pe181_p"}, {"name": "L-Tyrosine", "notes": {"original_bigg_ids": ["tyr_DASH_L_c"]}, "charge": 0, "formula": "C9H11NO3", "compartment": "c", "id": "tyr__L_c"}, {"name": "Phosphatidylglycerol (dioctadec-11-enoyl, n-C18:1)", "notes": {"original_bigg_ids": ["pg181_p"]}, "charge": -1, "formula": "C42H78O10P1", "compartment": "p", "id": "pg181_p"}, {"name": "Flavin adenine dinucleotide oxidized", "notes": {"original_bigg_ids": ["fad_c"]}, "charge": -2, "formula": "C27H31N9O15P2", "compartment": "c", "id": "fad_c"}, {"name": "Cardiolipin (tetrahexadecanoyl, n-C16:0)", "notes": {"original_bigg_ids": ["clpn160_p"]}, "charge": -2, "formula": "C73H140O17P2", "compartment": "p", "id": "clpn160_p"}, {"name": "Calcium", "notes": {"original_bigg_ids": ["ca2_c"]}, "charge": 2, "formula": "Ca", "compartment": "c", "id": "ca2_c"}, {"name": "[4Fe-4S] iron-sulfur cluster", "notes": {"original_bigg_ids": ["4fe4s_c"]}, "charge": 2, "formula": "S4Fe4", "compartment": "c", "id": "4fe4s_c"}, {"name": "Coenzyme A", "notes": {"original_bigg_ids": ["coa_c"]}, "charge": -4, "formula": "C21H32N7O16P3S", "compartment": "c", "id": "coa_c"}, {"name": "Phosphatidylglycerol (dioctadec-11-enoyl, n-C18:1)", "notes": {"original_bigg_ids": ["pg181_c"]}, "charge": -1, "formula": "C42H78O10P1", "compartment": "c", "id": "pg181_c"}, {"name": "H2O", "notes": {"original_bigg_ids": ["h2o_c"]}, "charge": 0, "formula": "H2O", "compartment": "c", "id": "h2o_c"}, {"name": "H+", "notes": {"original_bigg_ids": ["h_c"]}, "charge": 1, "formula": "H", "compartment": "c", "id": "h_c"}, {"name": "Putrescine", "notes": {"original_bigg_ids": ["ptrc_c"]}, "charge": 2, "formula": "C4H14N2", "compartment": "c", "id": "ptrc_c"}, {"name": "2-Octaprenyl-6-hydroxyphenol", "notes": {"original_bigg_ids": ["2ohph_c"]}, "charge": 0, "formula": "C46H70O2", "compartment": "c", "id": "2ohph_c"}, {"name": "KDO(2)-lipid IV(A)", "notes": {"original_bigg_ids": ["kdo2lipid4_e"]}, "charge": -6, "formula": "C84H148N2O37P2", "compartment": "e", "id": "kdo2lipid4_e"}, {"name": "Two disacharide linked murein units, pentapeptide crosslinked tetrapeptide (A2pm->D-ala) (middle of chain)", "notes": {"original_bigg_ids": ["murein5px4p_p"]}, "charge": -4, "formula": "C77H117N15O40", "compartment": "p", "id": "murein5px4p_p"}, {"name": "(R)-Propane-1,2-diol", "notes": {"original_bigg_ids": ["12ppd_DASH_R_e"]}, "charge": 0, "formula": "C3H8O2", "compartment": "e", "id": "12ppd__R_e"}, {"name": "(S)-Propane-1,2-diol", "notes": {"original_bigg_ids": ["12ppd_DASH_S_e"]}, "charge": 0, "formula": "C3H8O2", "compartment": "e", "id": "12ppd__S_e"}, {"name": "1,4-alpha-D-glucan", "notes": {"original_bigg_ids": ["14glucan_e"]}, "charge": 0, "formula": "C36H62O31", "compartment": "e", "id": "14glucan_e"}, {"name": "1,5-Diaminopentane", "notes": {"original_bigg_ids": ["15dap_e"]}, "charge": 2, "formula": "C5H16N2", "compartment": "e", "id": "15dap_e"}, {"name": "2',3'-Cyclic AMP", "notes": {"original_bigg_ids": ["23camp_e"]}, "charge": -1, "formula": "C10H11N5O6P", "compartment": "e", "id": "23camp_e"}, {"name": "2',3'-Cyclic CMP", "notes": {"original_bigg_ids": ["23ccmp_e"]}, "charge": -1, "formula": "C9H11N3O7P", "compartment": "e", "id": "23ccmp_e"}, {"name": "2',3'-Cyclic GMP", "notes": {"original_bigg_ids": ["23cgmp_e"]}, "charge": -1, "formula": "C10H11N5O7P", "compartment": "e", "id": "23cgmp_e"}, {"name": "2',3'-Cyclic UMP", "notes": {"original_bigg_ids": ["23cump_e"]}, "charge": -1, "formula": "C9H10N2O8P", "compartment": "e", "id": "23cump_e"}, {"name": "2,3-diaminopropionate", "notes": {"original_bigg_ids": ["23dappa_e"]}, "charge": 1, "formula": "C3H9N2O2", "compartment": "e", "id": "23dappa_e"}, {"name": "Meso-2,6-Diaminoheptanedioate", "notes": {"original_bigg_ids": ["26dap_DASH_M_e"]}, "charge": 0, "formula": "C7H14N2O4", "compartment": "e", "id": "26dap__M_e"}, {"name": "2-Dehydro-3-deoxy-D-gluconate", "notes": {"original_bigg_ids": ["2ddglcn_e"]}, "charge": -1, "formula": "C6H9O6", "compartment": "e", "id": "2ddglcn_e"}, {"name": "3,4-Dihydroxyphenylacetaldehyde", "notes": {"original_bigg_ids": ["34dhpac_e"]}, "charge": 0, "formula": "C8H8O3", "compartment": "e", "id": "34dhpac_e"}, {"name": "3'-AMP", "notes": {"original_bigg_ids": ["3amp_e"]}, "charge": -2, "formula": "C10H12N5O7P", "compartment": "e", "id": "3amp_e"}, {"name": "3'-cmp", "notes": {"original_bigg_ids": ["3cmp_e"]}, "charge": -2, "formula": "C9H12N3O8P", "compartment": "e", "id": "3cmp_e"}, {"name": "3'-GMP", "notes": {"original_bigg_ids": ["3gmp_e"]}, "charge": -2, "formula": "C10H12N5O8P", "compartment": "e", "id": "3gmp_e"}, {"name": "3-hydroxycinnamic acid", "notes": {"original_bigg_ids": ["3hcinnm_e"]}, "charge": -1, "formula": "C9H7O3", "compartment": "e", "id": "3hcinnm_e"}, {"name": "3-Hydroxypropanoate", "notes": {"original_bigg_ids": ["3hpp_e"]}, "charge": -1, "formula": "C3H5O3", "compartment": "e", "id": "3hpp_e"}, {"name": "3-(3-hydroxy-phenyl)propionate", "notes": {"original_bigg_ids": ["3hpppn_e"]}, "charge": -1, "formula": "C9H9O3", "compartment": "e", "id": "3hpppn_e"}, {"name": "3'-UMP", "notes": {"original_bigg_ids": ["3ump_e"]}, "charge": -2, "formula": "C9H11N2O9P", "compartment": "e", "id": "3ump_e"}, {"name": "4-Aminobutanoate", "notes": {"original_bigg_ids": ["4abut_e"]}, "charge": 0, "formula": "C4H9NO2", "compartment": "e", "id": "4abut_e"}, {"name": "4-Hydroxyphenylacetaldehyde", "notes": {"original_bigg_ids": ["4hoxpacd_e"]}, "charge": 0, "formula": "C8H8O2", "compartment": "e", "id": "4hoxpacd_e"}, {"name": "5-Dehydro-D-gluconate", "notes": {"original_bigg_ids": ["5dglcn_e"]}, "charge": -1, "formula": "C6H9O7", "compartment": "e", "id": "5dglcn_e"}, {"name": "5-Methylthio-D-ribose", "notes": {"original_bigg_ids": ["5mtr_e"]}, "charge": 0, "formula": "C6H12O4S", "compartment": "e", "id": "5mtr_e"}, {"name": "L-alanine-D-glutamate", "notes": {"original_bigg_ids": ["LalaDglu_e"]}, "charge": -1, "formula": "C8H13N2O5", "compartment": "e", "id": "LalaDglu_e"}, {"name": "L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate", "notes": {"original_bigg_ids": ["LalaDgluMdap_e"]}, "charge": -1, "formula": "C15H25N4O8", "compartment": "e", "id": "LalaDgluMdap_e"}, {"name": "L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine", "notes": {"original_bigg_ids": ["LalaDgluMdapDala_e"]}, "charge": -1, "formula": "C18H30N5O9", "compartment": "e", "id": "LalaDgluMdapDala_e"}, {"name": "L-alanine-L-glutamate", "notes": {"original_bigg_ids": ["LalaLglu_e"]}, "charge": -1, "formula": "C8H13N2O5", "compartment": "e", "id": "LalaLglu_e"}, {"name": "Acetate", "notes": {"original_bigg_ids": ["ac_e"]}, "charge": -1, "formula": "C2H3O2", "compartment": "e", "id": "ac_e"}, {"name": "Acetoacetate", "notes": {"original_bigg_ids": ["acac_e"]}, "charge": -1, "formula": "C4H5O3", "compartment": "e", "id": "acac_e"}, {"name": "Acetaldehyde", "notes": {"original_bigg_ids": ["acald_e"]}, "charge": 0, "formula": "C2H4O", "compartment": "e", "id": "acald_e"}, {"name": "N-Acetyl-D-galactosamine", "notes": {"original_bigg_ids": ["acgal_e"]}, "charge": 0, "formula": "C8H15NO6", "compartment": "e", "id": "acgal_e"}, {"name": "N-Acetyl-D-galactosamine 1-phosphate", "notes": {"original_bigg_ids": ["acgal1p_e"]}, "charge": -2, "formula": "C8H14NO9P", "compartment": "e", "id": "acgal1p_e"}, {"name": "N-Acetyl-D-glucosamine", "notes": 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["ala_DASH_B_e"]}, "charge": 0, "formula": "C3H7NO2", "compartment": "e", "id": "ala_B_e"}, {"name": "D-Alanine", "notes": {"original_bigg_ids": ["ala_DASH_D_e"]}, "charge": 0, "formula": "C3H7NO2", "compartment": "e", "id": "ala__D_e"}, {"name": "L-Alanine", "notes": {"original_bigg_ids": ["ala_DASH_L_e"]}, "charge": 0, "formula": "C3H7NO2", "compartment": "e", "id": "ala__L_e"}, {"name": "D-Alanyl-D-alanine", "notes": {"original_bigg_ids": ["alaala_e"]}, "charge": 0, "formula": "C6H12N2O3", "compartment": "e", "id": "alaala_e"}, {"name": "D-Allose", "notes": {"original_bigg_ids": ["all_DASH_D_e"]}, "charge": 0, "formula": "C6H12O6", "compartment": "e", "id": "all__D_e"}, {"name": "Allantoin", "notes": {"original_bigg_ids": ["alltn_e"]}, "charge": 0, "formula": "C4H6N4O3", "compartment": "e", "id": "alltn_e"}, {"name": "AMP", "notes": {"original_bigg_ids": ["amp_e"]}, "charge": -2, "formula": "C10H12N5O7P", "compartment": "e", "id": "amp_e"}, {"name": 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"id": "mal__L_e"}, {"name": "Maltose", "notes": {"original_bigg_ids": ["malt_e"]}, "charge": 0, "formula": "C12H22O11", "compartment": "e", "id": "malt_e"}, {"name": "Maltohexaose", "notes": {"original_bigg_ids": ["malthx_e"]}, "charge": 0, "formula": "C36H62O31", "compartment": "e", "id": "malthx_e"}, {"name": "Maltopentaose", "notes": {"original_bigg_ids": ["maltpt_e"]}, "charge": 0, "formula": "C30H52O26", "compartment": "e", "id": "maltpt_e"}, {"name": "Maltotriose", "notes": {"original_bigg_ids": ["malttr_e"]}, "charge": 0, "formula": "C18H32O16", "compartment": "e", "id": "malttr_e"}, {"name": "Maltotetraose", "notes": {"original_bigg_ids": ["maltttr_e"]}, "charge": 0, "formula": "C24H42O21", "compartment": "e", "id": "maltttr_e"}, {"name": "D-Mannose", "notes": {"original_bigg_ids": ["man_e"]}, "charge": 0, "formula": "C6H12O6", "compartment": "e", "id": "man_e"}, {"name": "D-Mannose 6-phosphate", "notes": {"original_bigg_ids": ["man6p_e"]}, "charge": -2, "formula": "C6H11O9P", 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{"name": "Molybdate", "notes": {"original_bigg_ids": ["mobd_e"]}, "charge": -2, "formula": "MoO4", "compartment": "e", "id": "mobd_e"}, {"name": "Methanesulfonate", "notes": {"original_bigg_ids": ["mso3_e"]}, "charge": -1, "formula": "CH3O3S", "compartment": "e", "id": "mso3_e"}, {"name": "Nitrous oxide", "notes": {"original_bigg_ids": ["n2o_e"]}, "charge": 0, "formula": "N2O", "compartment": "e", "id": "n2o_e"}, {"name": "Sodium", "notes": {"original_bigg_ids": ["na1_e"]}, "charge": 1, "formula": "Na", "compartment": "e", "id": "na1_e"}, {"name": "Nicotinate", "notes": {"original_bigg_ids": ["nac_e"]}, "charge": -1, "formula": "C6H4NO2", "compartment": "e", "id": "nac_e"}, {"name": "Ammonium", "notes": {"original_bigg_ids": ["nh4_e"]}, "charge": 1, "formula": "H4N", "compartment": "e", "id": "nh4_e"}, {"name": "Nickel", "notes": {"original_bigg_ids": ["ni2_e"]}, "charge": 2, "formula": "Ni", "compartment": "e", "id": "ni2_e"}, {"name": "NMN", "notes": {"original_bigg_ids": ["nmn_e"]}, 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"2agpg140_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C14:1)", "notes": {"original_bigg_ids": ["2agpg141_c"]}, "charge": -1, "formula": "C20H38O9P1", "compartment": "c", "id": "2agpg141_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C14:1)", "notes": {"original_bigg_ids": ["2agpg141_p"]}, "charge": -1, "formula": "C20H38O9P1", "compartment": "p", "id": "2agpg141_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:0)", "notes": {"original_bigg_ids": ["2agpg160_c"]}, "charge": -1, "formula": "C22H44O9P1", "compartment": "c", "id": "2agpg160_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:0)", "notes": {"original_bigg_ids": ["2agpg160_p"]}, "charge": -1, "formula": "C22H44O9P1", "compartment": "p", "id": "2agpg160_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:1)", "notes": {"original_bigg_ids": ["2agpg161_p"]}, "charge": -1, "formula": "C22H42O9P1", "compartment": "p", "id": "2agpg161_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:1)", "notes": {"original_bigg_ids": ["2agpg161_c"]}, "charge": -1, "formula": "C22H42O9P1", "compartment": "c", "id": "2agpg161_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:0)", "notes": {"original_bigg_ids": ["2agpg180_c"]}, "charge": -1, "formula": "C24H48O9P1", "compartment": "c", "id": "2agpg180_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:0)", "notes": {"original_bigg_ids": ["2agpg180_p"]}, "charge": -1, "formula": "C24H48O9P1", "compartment": "p", "id": "2agpg180_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:1)", "notes": {"original_bigg_ids": ["2agpg181_p"]}, "charge": -1, "formula": "C24H46O9P1", "compartment": "p", "id": "2agpg181_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:1)", "notes": {"original_bigg_ids": ["2agpg181_c"]}, "charge": -1, "formula": "C24H46O9P1", "compartment": "c", "id": "2agpg181_c"}, {"name": "Phosphatidylglycerol (didodecanoyl, n-C12:0)", "notes": {"original_bigg_ids": ["pg120_c"]}, "charge": -1, "formula": "C30H58O10P1", "compartment": "c", "id": "pg120_c"}, {"name": "Phosphatidylglycerol (ditetradecanoyl, n-C14:0)", "notes": {"original_bigg_ids": ["pg140_c"]}, "charge": -1, "formula": "C34H66O10P1", "compartment": "c", "id": "pg140_c"}, {"name": "Phosphatidylglycerol (ditetradec-7-enoyl, n-C14:1)", "notes": {"original_bigg_ids": ["pg141_c"]}, "charge": -1, "formula": "C34H62O10P1", "compartment": "c", "id": "pg141_c"}, {"name": "Phosphatidylglycerol (dioctadecanoyl, n-C18:0)", "notes": {"original_bigg_ids": ["pg180_c"]}, "charge": -1, "formula": "C42H82O10P1", "compartment": "c", "id": "pg180_c"}, {"name": "2-Dehydro-L-gulonate", "notes": {"original_bigg_ids": ["2dhguln_c"]}, "charge": -1, "formula": "C6H9O7", "compartment": "c", "id": "2dhguln_c"}, {"name": "D-Gluconate", "notes": {"original_bigg_ids": ["glcn_c"]}, "charge": -1, "formula": "C6H11O7", "compartment": "c", "id": "glcn_c"}, {"name": "L-Idonate", "notes": {"original_bigg_ids": ["idon_DASH_L_c"]}, "charge": -1, "formula": "C6H11O7", "compartment": "c", "id": "idon__L_c"}, {"name": "4-Amino-2-methyl-5-phosphomethylpyrimidine", "notes": {"original_bigg_ids": ["4ampm_c"]}, "charge": -2, "formula": "C6H8N3O4P", "compartment": "c", "id": "4ampm_c"}, {"name": "2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate", "notes": {"original_bigg_ids": ["2mahmp_c"]}, "charge": -3, "formula": "C6H8N3O7P2", "compartment": "c", "id": "2mahmp_c"}, {"name": "3,4-Dihydroxyphenylacetaldehyde", "notes": {"original_bigg_ids": ["34dhpac_p"]}, "charge": 0, "formula": "C8H8O3", "compartment": "p", "id": "34dhpac_p"}, {"name": "Malonate semialdehyde", "notes": {"original_bigg_ids": ["msa_c"]}, "charge": -1, "formula": "C3H3O3", "compartment": "c", "id": "msa_c"}, {"name": "3-Aminoacrylate", "notes": {"original_bigg_ids": ["3amac_c"]}, "charge": -1, "formula": "C3H4NO2", "compartment": "c", "id": "3amac_c"}, {"name": "Trans-Dec-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["tdec2eACP_c"]}, "charge": -1, "formula": "C21H37N2O8PRS", "compartment": "c", "id": "tdec2eACP_c"}, {"name": "(R)-3-Hydroxydecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hdecACP_c"]}, "charge": -1, "formula": "C21H39N2O9PRS", "compartment": "c", "id": "3hdecACP_c"}, {"name": "Trans-Dodec-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["tddec2eACP_c"]}, "charge": -1, "formula": "C23H41N2O8PRS", "compartment": "c", "id": "tddec2eACP_c"}, {"name": "(R)-3-Hydroxydodecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hddecACP_c"]}, "charge": -1, "formula": "C23H43N2O9PRS", "compartment": "c", "id": "3hddecACP_c"}, {"name": "Trans-3-cis-5-dodecenoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["t3c5ddeceACP_c"]}, "charge": -1, "formula": "C23H39N2O8PRS", "compartment": "c", "id": "t3c5ddeceACP_c"}, {"name": "(R)-3-hydroxy-cis-dodec-5-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hcddec5eACP_c"]}, "charge": -1, "formula": "C23H41N2O9PRS", "compartment": "c", "id": "3hcddec5eACP_c"}, {"name": "(R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hmrsACP_c"]}, "charge": -1, "formula": "C25H47N2O9PRS", "compartment": "c", "id": "3hmrsACP_c"}, {"name": "Trans-Tetradec-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["tmrs2eACP_c"]}, "charge": -1, "formula": "C25H45N2O8PRS", "compartment": "c", "id": "tmrs2eACP_c"}, {"name": "Trans-3-cis-7-myristoleoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["t3c7mrseACP_c"]}, "charge": -1, "formula": "C25H43N2O8PRS", "compartment": "c", "id": "t3c7mrseACP_c"}, {"name": "(R)-3-hydroxy-cis-myristol-7-eoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hcmrs7eACP_c"]}, "charge": -1, "formula": "C25H45N2O9PRS", "compartment": "c", "id": "3hcmrs7eACP_c"}, {"name": "R-3-hydroxypalmitoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hpalmACP_c"]}, "charge": -1, "formula": "C27H51N2O9PRS", "compartment": "c", "id": "3hpalmACP_c"}, {"name": "Trans-Hexadec-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["tpalm2eACP_c"]}, "charge": -1, "formula": "C27H49N2O8PRS", "compartment": "c", "id": "tpalm2eACP_c"}, {"name": "Trans-3-cis-9-palmitoleoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["t3c9palmeACP_c"]}, "charge": -1, "formula": "C27H47N2O8PRS", "compartment": "c", "id": "t3c9palmeACP_c"}, {"name": "(R)-3-hydroxy-cis-palm-9-eoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hcpalm9eACP_c"]}, "charge": -1, "formula": "C27H49N2O9PRS", "compartment": "c", "id": "3hcpalm9eACP_c"}, {"name": "(R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hoctaACP_c"]}, "charge": -1, "formula": "C29H55N2O9PRS", "compartment": "c", "id": "3hoctaACP_c"}, {"name": "Trans-octadec-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["toctd2eACP_c"]}, "charge": -1, "formula": "C29H53N2O8PRS", "compartment": "c", "id": "toctd2eACP_c"}, {"name": "Trans-3-cis-11-vacceoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["t3c11vaceACP_c"]}, "charge": -1, "formula": "C29H51N2O8PRS", "compartment": "c", "id": "t3c11vaceACP_c"}, {"name": "(R)-3-hydroxy-cis-vacc-11-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hcvac11eACP_c"]}, "charge": -1, "formula": "C29H53N2O9PRS", "compartment": "c", "id": "3hcvac11eACP_c"}, {"name": "But-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["but2eACP_c"]}, "charge": -1, "formula": "C15H25N2O8PRS", "compartment": "c", "id": "but2eACP_c"}, {"name": "(3R)-3-Hydroxyacyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3haACP_c"]}, "charge": -1, "formula": "C15H27N2O9PRS", "compartment": "c", "id": "3haACP_c"}, {"name": "(R)-3-Hydroxyhexanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hhexACP_c"]}, "charge": -1, "formula": "C17H31N2O9PRS", "compartment": "c", "id": "3hhexACP_c"}, {"name": "Trans-Hex-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["thex2eACP_c"]}, "charge": -1, "formula": "C17H29N2O8PRS", "compartment": "c", "id": "thex2eACP_c"}, {"name": "(R)-3-Hydroxyoctanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hoctACP_c"]}, "charge": -1, "formula": "C19H35N2O9PRS", "compartment": "c", "id": "3hoctACP_c"}, {"name": "Trans-Oct-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["toct2eACP_c"]}, "charge": -1, "formula": "C19H33N2O8PRS", "compartment": "c", "id": "toct2eACP_c"}, {"name": "3-Hydroxypropanoate", "notes": {"original_bigg_ids": ["3hpp_p"]}, "charge": -1, "formula": "C3H5O3", "compartment": "p", "id": "3hpp_p"}, {"name": "3-Hydroxypropanoate", "notes": {"original_bigg_ids": ["3hpp_c"]}, "charge": -1, "formula": "C3H5O3", "compartment": "c", "id": "3hpp_c"}, {"name": "3-keto-L-gulonate-6-phosphate", "notes": {"original_bigg_ids": ["3dhgulnp_c"]}, "charge": -3, "formula": "C6H8O10P", "compartment": "c", "id": "3dhgulnp_c"}, {"name": "3-Dehydro-L-gulonate", "notes": {"original_bigg_ids": ["3dhguln_c"]}, "charge": -1, "formula": "C6H9O7", "compartment": "c", "id": "3dhguln_c"}, {"name": "Phosphate", "notes": {"original_bigg_ids": ["pi_p"]}, "charge": -2, "formula": "HO4P", "compartment": "p", "id": "pi_p"}, {"name": "Uridine", "notes": {"original_bigg_ids": ["uri_p"]}, "charge": 0, "formula": "C9H12N2O6", "compartment": "p", "id": "uri_p"}, {"name": "Cytidine", "notes": {"original_bigg_ids": ["cytd_p"]}, "charge": 0, "formula": "C9H13N3O5", "compartment": "p", "id": "cytd_p"}, {"name": "Adenosine", "notes": {"original_bigg_ids": ["adn_p"]}, "charge": 0, "formula": "C10H13N5O4", "compartment": "p", "id": "adn_p"}, {"name": "Guanosine", "notes": {"original_bigg_ids": ["gsn_p"]}, "charge": 0, "formula": "C10H13N5O5", "compartment": "p", "id": "gsn_p"}, {"name": "3-Oxodecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3odecACP_c"]}, "charge": -1, "formula": "C21H37N2O9PRS", "compartment": "c", "id": "3odecACP_c"}, {"name": "3-Oxododecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3oddecACP_c"]}, "charge": -1, "formula": "C23H41N2O9PRS", "compartment": "c", "id": "3oddecACP_c"}, {"name": "3-oxo-cis-dodec-5-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ocddec5eACP_c"]}, "charge": -1, "formula": "C23H39N2O9PRS", "compartment": "c", "id": "3ocddec5eACP_c"}, {"name": "3-Oxotetradecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3omrsACP_c"]}, "charge": -1, "formula": "C25H45N2O9PRS", "compartment": "c", "id": "3omrsACP_c"}, {"name": "3-oxo-cis-myristol-7-eoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ocmrs7eACP_c"]}, "charge": -1, "formula": "C25H43N2O9PRS", "compartment": "c", "id": "3ocmrs7eACP_c"}, {"name": "3-Oxohexadecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3opalmACP_c"]}, "charge": -1, "formula": "C27H49N2O9PRS", "compartment": "c", "id": "3opalmACP_c"}, {"name": "3-oxo-cis-palm-9-eoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ocpalm9eACP_c"]}, "charge": -1, "formula": "C27H47N2O9PRS", "compartment": "c", "id": "3ocpalm9eACP_c"}, {"name": "3-Oxooctadecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ooctdACP_c"]}, "charge": -1, "formula": "C29H53N2O9PRS", "compartment": "c", "id": "3ooctdACP_c"}, {"name": "3-oxo-cis-vacc-11-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ocvac11eACP_c"]}, "charge": -1, "formula": "C29H51N2O9PRS", "compartment": "c", "id": "3ocvac11eACP_c"}, {"name": "Acetoacetyl-ACP", "notes": {"original_bigg_ids": ["actACP_c"]}, "charge": -1, "formula": "C15H25N2O9PRS", "compartment": "c", "id": "actACP_c"}, {"name": "3-Oxohexanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ohexACP_c"]}, "charge": -1, "formula": "C17H29N2O9PRS", "compartment": "c", "id": "3ohexACP_c"}, {"name": "3-Oxooctanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ooctACP_c"]}, "charge": -1, "formula": "C19H33N2O9PRS", "compartment": "c", "id": "3ooctACP_c"}, {"name": "CO2", "notes": {"original_bigg_ids": ["co2_c"]}, "charge": 0, "formula": "CO2", "compartment": "c", "id": "co2_c"}, {"name": "Acyl carrier protein", "notes": {"original_bigg_ids": ["ACP_c"]}, "charge": -1, "formula": "C11H21N2O7PRS", "compartment": "c", "id": "ACP_c"}, {"name": "Octanoyl-ACP (n-C8:0ACP)", "notes": {"original_bigg_ids": ["ocACP_c"]}, "charge": -1, "formula": "C19H35N2O8PRS", "compartment": "c", "id": "ocACP_c"}, {"name": "Malonyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["malACP_c"]}, "charge": -2, "formula": "C14H22N2O10PRS", "compartment": "c", "id": "malACP_c"}, {"name": "Decanoyl-ACP (n-C10:0ACP)", "notes": {"original_bigg_ids": ["dcaACP_c"]}, "charge": -1, "formula": "C21H39N2O8PRS", "compartment": "c", "id": "dcaACP_c"}, {"name": "Cis-dec-3-enoyl-[acyl-carrier protein] (n-C10:1)", "notes": {"original_bigg_ids": ["cdec3eACP_c"]}, "charge": -1, "formula": "C21H37N2O8PRS", "compartment": "c", "id": "cdec3eACP_c"}, {"name": "Dodecanoyl-ACP (n-C12:0ACP)", "notes": {"original_bigg_ids": ["ddcaACP_c"]}, "charge": -1, "formula": "C23H43N2O8PRS", "compartment": "c", "id": "ddcaACP_c"}, {"name": "Cis-dodec-5-enoyl-[acyl-carrier protein] (n-C12:1)", "notes": {"original_bigg_ids": ["cddec5eACP_c"]}, "charge": -1, "formula": "C23H41N2O8PRS", "compartment": "c", "id": "cddec5eACP_c"}, {"name": "Myristoyl-ACP (n-C14:0ACP)", "notes": {"original_bigg_ids": ["myrsACP_c"]}, "charge": -1, "formula": "C25H47N2O8PRS", "compartment": "c", "id": "myrsACP_c"}, {"name": "Cis-tetradec-7-enoyl-[acyl-carrier protein] (n-C14:1)", "notes": {"original_bigg_ids": ["tdeACP_c"]}, "charge": -1, "formula": "C25H45N2O8PRS", "compartment": "c", "id": "tdeACP_c"}, {"name": "Palmitoyl-ACP (n-C16:0ACP)", "notes": {"original_bigg_ids": ["palmACP_c"]}, "charge": -1, "formula": "C27H51N2O8PRS", "compartment": "c", "id": "palmACP_c"}, {"name": "Cis-hexadec-9-enoyl-[acyl-carrier protein] (n-C16:1)", "notes": {"original_bigg_ids": ["hdeACP_c"]}, "charge": -1, "formula": "C27H49N2O8PRS", "compartment": "c", "id": "hdeACP_c"}, {"name": "Butyryl-ACP (n-C4:0ACP)", "notes": {"original_bigg_ids": ["butACP_c"]}, "charge": -1, "formula": "C15H27N2O8PRS", "compartment": "c", "id": "butACP_c"}, {"name": "Hexanoyl-ACP (n-C6:0ACP)", "notes": {"original_bigg_ids": ["hexACP_c"]}, "charge": -1, "formula": "C17H31N2O8PRS", "compartment": "c", "id": "hexACP_c"}, {"name": "L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate", "notes": {"original_bigg_ids": ["LalaDgluMdap_c"]}, "charge": -1, "formula": "C15H25N4O8", "compartment": "c", "id": "LalaDgluMdap_c"}, {"name": "L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate", "notes": {"original_bigg_ids": ["LalaDgluMdap_p"]}, "charge": -1, "formula": "C15H25N4O8", "compartment": "p", "id": "LalaDgluMdap_p"}, {"name": "4-Hydroxyphenylacetaldehyde", "notes": {"original_bigg_ids": ["4hoxpacd_p"]}, "charge": 0, "formula": "C8H8O2", "compartment": "p", "id": "4hoxpacd_p"}, {"name": "4-Hydroxy-L-threonine", "notes": {"original_bigg_ids": ["4hthr_c"]}, "charge": 0, "formula": "C4H9NO4", "compartment": "c", "id": "4hthr_c"}, {"name": "O-Phospho-4-hydroxy-L-threonine", "notes": {"original_bigg_ids": ["phthr_c"]}, "charge": -2, "formula": "C4H8NO7P", "compartment": "c", "id": "phthr_c"}, {"name": "L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine", "notes": {"original_bigg_ids": ["LalaDgluMdapDala_c"]}, "charge": -1, "formula": "C18H30N5O9", "compartment": "c", "id": "LalaDgluMdapDala_c"}, {"name": "D-Alanine", "notes": {"original_bigg_ids": ["ala_DASH_D_c"]}, "charge": 0, "formula": "C3H7NO2", "compartment": "c", "id": "ala__D_c"}, {"name": "D-Alanine", "notes": {"original_bigg_ids": ["ala_DASH_D_p"]}, "charge": 0, "formula": "C3H7NO2", "compartment": "p", "id": "ala__D_p"}, {"name": "L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine", "notes": {"original_bigg_ids": ["LalaDgluMdapDala_p"]}, "charge": -1, "formula": "C18H30N5O9", "compartment": "p", "id": "LalaDgluMdapDala_p"}, {"name": "5-Dehydro-D-gluconate", "notes": {"original_bigg_ids": ["5dglcn_p"]}, "charge": -1, "formula": "C6H9O7", "compartment": "p", "id": "5dglcn_p"}, {"name": "5'-Deoxyadenosine", "notes": {"original_bigg_ids": ["dad_DASH_5_c"]}, "charge": 0, "formula": "C10H13N5O3", "compartment": "c", "id": "dad_5_c"}, {"name": "Adenine", "notes": {"original_bigg_ids": ["ade_c"]}, "charge": 0, "formula": "C5H5N5", "compartment": "c", "id": "ade_c"}, {"name": "5-Methylthio-D-ribose", "notes": {"original_bigg_ids": ["5mtr_p"]}, "charge": 0, "formula": "C6H12O4S", "compartment": "p", "id": "5mtr_p"}, {"name": "5-Methylthio-D-ribose", "notes": {"original_bigg_ids": ["5mtr_c"]}, "charge": 0, "formula": "C6H12O4S", "compartment": "c", "id": "5mtr_c"}, {"name": "D-Arabinose 5-phosphate", "notes": {"original_bigg_ids": ["ara5p_c"]}, "charge": -2, "formula": "C5H9O8P", "compartment": "c", "id": "ara5p_c"}, {"name": "D-Ribulose 5-phosphate", "notes": {"original_bigg_ids": ["ru5p_DASH_D_c"]}, "charge": -2, "formula": "C5H9O8P", "compartment": "c", "id": "ru5p__D_c"}, {"name": "Cis-octadec-11-enoyl-[acyl-carrier protein] (n-C18:1)", "notes": {"original_bigg_ids": ["octeACP_c"]}, "charge": -1, "formula": "C29H53N2O8PRS", "compartment": "c", "id": "octeACP_c"}, {"name": "Octadecanoyl-ACP (n-C18:0ACP)", "notes": {"original_bigg_ids": ["ocdcaACP_c"]}, "charge": -1, "formula": "C29H55N2O8PRS", "compartment": "c", "id": "ocdcaACP_c"}, {"name": "Decanoate (n-C10:0)", "notes": {"original_bigg_ids": ["dca_c"]}, "charge": -1, "formula": "C10H19O2", "compartment": "c", "id": "dca_c"}, {"name": "Octanoate (n-C8:0)", "notes": {"original_bigg_ids": ["octa_c"]}, "charge": -1, "formula": "C8H15O2", "compartment": "c", "id": "octa_c"}, {"name": "Methylglyoxal", "notes": {"original_bigg_ids": ["mthgxl_c"]}, "charge": 0, "formula": "C3H4O2", "compartment": "c", "id": "mthgxl_c"}, {"name": "Hydrogen peroxide", "notes": {"original_bigg_ids": ["h2o2_c"]}, "charge": 0, "formula": "H2O2", "compartment": "c", "id": "h2o2_c"}, {"name": "O2", "notes": {"original_bigg_ids": ["o2_c"]}, "charge": 0, "formula": "O2", "compartment": "c", "id": "o2_c"}, {"name": "Aminoacetone", "notes": {"original_bigg_ids": ["aact_c"]}, "charge": 1, "formula": "C3H8NO", "compartment": "c", "id": "aact_c"}, {"name": "Undecaprenyl-diphospho N-acetylglucosamine-N-acetylmannosaminuronate-N-acetamido-4,6-dideoxy-D-galactose", "notes": {"original_bigg_ids": ["unagamuf_c"]}, "charge": -3, "formula": "C79H126N3O22P2", "compartment": "c", "id": "unagamuf_c"}, {"name": "DTDP-4-acetamido-4,6-dideoxy-D-galactose", "notes": {"original_bigg_ids": ["dtdp4aaddg_c"]}, "charge": -2, "formula": "C18H27N3O15P2", "compartment": "c", "id": "dtdp4aaddg_c"}, {"name": "DTDP", "notes": {"original_bigg_ids": ["dtdp_c"]}, "charge": -3, "formula": "C10H13N2O11P2", "compartment": "c", "id": "dtdp_c"}, {"name": "Undecaprenyl-diphospho-N-acetylglucosamine-N-acetylmannosaminuronate", "notes": {"original_bigg_ids": ["unagamu_c"]}, "charge": -3, "formula": "C71H113N2O18P2", "compartment": "c", "id": "unagamu_c"}, {"name": "Maltohexaose", "notes": {"original_bigg_ids": ["malthx_c"]}, "charge": 0, "formula": "C36H62O31", "compartment": "c", "id": "malthx_c"}, {"name": "Maltohexaose", "notes": {"original_bigg_ids": ["malthx_p"]}, "charge": 0, "formula": "C36H62O31", "compartment": "p", "id": "malthx_p"}, {"name": "D-Glucose 6-phosphate", "notes": {"original_bigg_ids": ["g6p_c"]}, "charge": -2, "formula": "C6H11O9P", "compartment": "c", "id": "g6p_c"}, {"name": "Hydroquinone", "notes": {"original_bigg_ids": ["hqn_c"]}, "charge": 0, "formula": "C6H6O2", "compartment": "c", "id": "hqn_c"}, {"name": "Arbutin 6-phosphate", "notes": {"original_bigg_ids": ["arbt6p_c"]}, "charge": -2, "formula": "C12H15O10P", "compartment": "c", "id": "arbt6p_c"}, {"name": "2-Oxoglutarate", "notes": {"original_bigg_ids": ["akg_c"]}, "charge": -2, "formula": "C5H4O5", "compartment": "c", "id": "akg_c"}, {"name": "Succinic semialdehyde", "notes": {"original_bigg_ids": ["sucsal_c"]}, "charge": -1, "formula": "C4H5O3", "compartment": "c", "id": "sucsal_c"}, {"name": "4-Aminobutanoate", "notes": {"original_bigg_ids": ["4abut_c"]}, "charge": 0, "formula": "C4H9NO2", "compartment": "c", "id": "4abut_c"}, {"name": "4-Aminobutanal", "notes": {"original_bigg_ids": ["4abutn_c"]}, "charge": 1, "formula": "C4H10NO", "compartment": "c", "id": "4abutn_c"}, {"name": "4-Aminobutanoate", "notes": {"original_bigg_ids": ["4abut_p"]}, "charge": 0, "formula": "C4H9NO2", "compartment": "p", "id": "4abut_p"}, {"name": "Acetoacetyl-CoA", "notes": {"original_bigg_ids": ["aacoa_c"]}, "charge": -4, "formula": "C25H36N7O18P3S", "compartment": "c", "id": "aacoa_c"}, {"name": "Acetate", "notes": {"original_bigg_ids": ["ac_c"]}, "charge": -1, "formula": "C2H3O2", "compartment": "c", "id": "ac_c"}, {"name": "Acetoacetate", "notes": {"original_bigg_ids": ["acac_c"]}, "charge": -1, "formula": "C4H5O3", "compartment": "c", "id": "acac_c"}, {"name": "3-Oxohexanoyl-CoA", "notes": {"original_bigg_ids": ["3ohcoa_c"]}, "charge": -4, "formula": "C27H40N7O18P3S", "compartment": "c", "id": "3ohcoa_c"}, {"name": "Butanoyl-CoA", "notes": {"original_bigg_ids": ["btcoa_c"]}, "charge": -4, "formula": "C25H38N7O17P3S", "compartment": "c", "id": "btcoa_c"}, {"name": "Hexanoyl-CoA (n-C6:0CoA)", "notes": {"original_bigg_ids": ["hxcoa_c"]}, "charge": -4, "formula": "C27H42N7O17P3S", "compartment": "c", "id": "hxcoa_c"}, {"name": "3-Oxooctanoyl-CoA", "notes": {"original_bigg_ids": ["3oocoa_c"]}, "charge": -4, "formula": "C29H44N7O18P3S", "compartment": "c", "id": "3oocoa_c"}, {"name": "3-Oxodecanoyl-CoA", "notes": {"original_bigg_ids": ["3odcoa_c"]}, "charge": -4, "formula": "C31H48N7O18P3S", "compartment": "c", "id": "3odcoa_c"}, {"name": "Octanoyl-CoA (n-C8:0CoA)", "notes": {"original_bigg_ids": ["occoa_c"]}, "charge": -4, "formula": "C29H46N7O17P3S", "compartment": "c", "id": "occoa_c"}, {"name": "3-Oxododecanoyl-CoA", "notes": {"original_bigg_ids": ["3oddcoa_c"]}, "charge": -4, "formula": "C33H52N7O18P3S", "compartment": "c", "id": "3oddcoa_c"}, {"name": "Decanoyl-CoA (n-C10:0CoA)", "notes": {"original_bigg_ids": ["dcacoa_c"]}, "charge": -4, "formula": "C31H50N7O17P3S", "compartment": "c", "id": "dcacoa_c"}, {"name": "3-Oxotetradecanoyl-CoA", "notes": {"original_bigg_ids": ["3otdcoa_c"]}, "charge": -4, "formula": "C35H56N7O18P3S", "compartment": "c", "id": "3otdcoa_c"}, {"name": "Dodecanoyl-CoA (n-C12:0CoA)", "notes": {"original_bigg_ids": ["ddcacoa_c"]}, "charge": -4, "formula": "C33H54N7O17P3S", "compartment": "c", "id": "ddcacoa_c"}, {"name": "3-Oxohexadecanoyl-CoA", "notes": {"original_bigg_ids": ["3ohdcoa_c"]}, "charge": -4, "formula": "C37H60N7O18P3S", "compartment": "c", "id": "3ohdcoa_c"}, {"name": "Tetradecanoyl-CoA (n-C14:0CoA)", "notes": {"original_bigg_ids": ["tdcoa_c"]}, "charge": -4, "formula": "C35H58N7O17P3S", "compartment": "c", "id": "tdcoa_c"}, {"name": "3-Oxooctadecanoyl-CoA", "notes": {"original_bigg_ids": ["3oodcoa_c"]}, "charge": -4, "formula": "C39H64N7O18P3S", "compartment": "c", "id": "3oodcoa_c"}, {"name": "Palmitoyl-CoA (n-C16:0CoA)", "notes": {"original_bigg_ids": ["pmtcoa_c"]}, "charge": -4, "formula": "C37H62N7O17P3S", "compartment": "c", "id": "pmtcoa_c"}, {"name": "Acetoacetate", "notes": {"original_bigg_ids": ["acac_p"]}, "charge": -1, "formula": "C4H5O3", "compartment": "p", "id": "acac_p"}, {"name": "Acetaldehyde", "notes": {"original_bigg_ids": ["acald_c"]}, "charge": 0, "formula": "C2H4O", "compartment": "c", "id": "acald_c"}, {"name": "Acetaldehyde", "notes": {"original_bigg_ids": ["acald_p"]}, "charge": 0, "formula": "C2H4O", "compartment": "p", "id": "acald_p"}, {"name": "Anthranilate", "notes": {"original_bigg_ids": ["anth_c"]}, "charge": -1, "formula": "C7H6NO2", "compartment": "c", "id": "anth_c"}, {"name": "N-Acetylanthranilate", "notes": {"original_bigg_ids": ["acanth_c"]}, "charge": -1, "formula": "C9H8NO3", "compartment": "c", "id": "acanth_c"}, {"name": "Adenosyl cobinamide phosphate", "notes": {"original_bigg_ids": ["adocbip_c"]}, "charge": -1, "formula": "C58H83CoN16O14P", "compartment": "c", "id": "adocbip_c"}, {"name": "Adenosine-GDP-cobinamide", "notes": {"original_bigg_ids": ["agdpcbi_c"]}, "charge": -1, "formula": "C68H95CoN21O21P2", "compartment": "c", "id": "agdpcbi_c"}, {"name": "Bicarbonate", "notes": {"original_bigg_ids": ["hco3_c"]}, "charge": -1, "formula": "CHO3", "compartment": "c", "id": "hco3_c"}, {"name": "Propionate (n-C3:0)", "notes": {"original_bigg_ids": ["ppa_c"]}, "charge": -1, "formula": "C3H5O2", "compartment": "c", "id": "ppa_c"}, {"name": "Propanoyl-CoA", "notes": {"original_bigg_ids": ["ppcoa_c"]}, "charge": -4, "formula": "C24H36N7O17P3S", "compartment": "c", "id": "ppcoa_c"}, {"name": "N-Acetyl-D-galactosamine", "notes": {"original_bigg_ids": ["acgal_p"]}, "charge": 0, "formula": "C8H15NO6", "compartment": "p", "id": "acgal_p"}, {"name": "N-Acetyl-D-galactosamine 1-phosphate", "notes": {"original_bigg_ids": ["acgal1p_p"]}, "charge": -2, "formula": "C8H14NO9P", "compartment": "p", "id": "acgal1p_p"}, {"name": "N-Acetyl-D-glucosamine 1-phosphate", "notes": {"original_bigg_ids": ["acgam1p_p"]}, "charge": -2, "formula": "C8H14NO9P", "compartment": "p", "id": "acgam1p_p"}, {"name": "N-Acetyl-D-glucosamine", "notes": {"original_bigg_ids": ["acgam_p"]}, "charge": 0, "formula": "C8H15NO6", "compartment": "p", "id": "acgam_p"}, {"name": "N-Acetyl-D-glucosamine", "notes": {"original_bigg_ids": ["acgam_c"]}, "charge": 0, "formula": "C8H15NO6", "compartment": "c", "id": "acgam_c"}, {"name": "N-Acetyl-D-glucosamine 6-phosphate", "notes": {"original_bigg_ids": ["acgam6p_c"]}, "charge": -2, "formula": "C8H14NO9P", "compartment": "c", "id": "acgam6p_c"}, {"name": "Undecaprenyl diphospho N-acetyl-glucosamine", "notes": {"original_bigg_ids": ["unaga_c"]}, "charge": -2, "formula": "C63H103NO12P2", "compartment": "c", "id": "unaga_c"}, {"name": "UDP-N-acetyl-D-glucosamine", "notes": {"original_bigg_ids": ["uacgam_c"]}, "charge": -2, "formula": "C17H25N3O17P2", "compartment": "c", "id": "uacgam_c"}, {"name": "Undecaprenyl phosphate", "notes": {"original_bigg_ids": ["udcpp_c"]}, "charge": -2, "formula": "C55H89O4P", "compartment": "c", "id": "udcpp_c"}, {"name": "UMP", "notes": {"original_bigg_ids": ["ump_c"]}, "charge": -2, "formula": "C9H11N2O9P", "compartment": "c", "id": "ump_c"}, {"name": "Pyruvate", "notes": {"original_bigg_ids": ["pyr_c"]}, "charge": -1, "formula": "C3H3O3", "compartment": "c", "id": "pyr_c"}, {"name": "Phosphoenolpyruvate", "notes": {"original_bigg_ids": ["pep_c"]}, "charge": -3, "formula": "C3H2O6P", "compartment": "c", "id": "pep_c"}, {"name": "N-Acetyl-L-glutamyl 5-phosphate", "notes": {"original_bigg_ids": ["acg5p_c"]}, "charge": -3, "formula": "C7H9NO8P", "compartment": "c", "id": "acg5p_c"}, {"name": "N-Acetyl-L-glutamate", "notes": {"original_bigg_ids": ["acglu_c"]}, "charge": -2, "formula": "C7H9NO5", "compartment": "c", "id": "acglu_c"}, {"name": "(S)-2-Aceto-2-hydroxybutanoate", "notes": {"original_bigg_ids": ["2ahbut_c"]}, "charge": -1, "formula": "C6H9O4", "compartment": "c", "id": "2ahbut_c"}, {"name": "2-Oxobutanoate", "notes": {"original_bigg_ids": ["2obut_c"]}, "charge": -1, "formula": "C4H5O3", "compartment": "c", "id": "2obut_c"}, {"name": "Acetyl phosphate", "notes": {"original_bigg_ids": ["actp_c"]}, "charge": -2, "formula": "C2H3O5P", "compartment": "c", "id": "actp_c"}, {"name": "(S)-2-Acetolactate", "notes": {"original_bigg_ids": ["alac_DASH_S_c"]}, "charge": -1, "formula": "C5H7O4", "compartment": "c", "id": "alac__S_c"}, {"name": "N-acetylmuramate 6-phosphate", "notes": {"original_bigg_ids": ["acmum6p_c"]}, "charge": -3, "formula": "C11H17NO11P", "compartment": "c", "id": "acmum6p_c"}, {"name": "D-Lactate", "notes": {"original_bigg_ids": ["lac_DASH_D_c"]}, "charge": -1, "formula": "C3H5O3", "compartment": "c", "id": "lac__D_c"}, {"name": "UDP-N-acetyl-D-mannosaminouronate", "notes": {"original_bigg_ids": ["uacmamu_c"]}, "charge": -3, "formula": "C17H22N3O18P2", "compartment": "c", "id": "uacmamu_c"}, {"name": "UDP", "notes": {"original_bigg_ids": ["udp_c"]}, "charge": -3, "formula": "C9H11N2O12P2", "compartment": "c", "id": "udp_c"}, {"name": "N-Acetyl-D-mannosamine 6-phosphate", "notes": {"original_bigg_ids": ["acmanap_c"]}, "charge": -2, "formula": "C8H14NO9P", "compartment": "c", "id": "acmanap_c"}, {"name": "N-Acetyl-D-mannosamine", "notes": {"original_bigg_ids": ["acmana_p"]}, "charge": 0, "formula": "C8H15NO6", "compartment": "p", "id": "acmana_p"}, {"name": "N-Acetylmuramate", "notes": {"original_bigg_ids": ["acmum_p"]}, "charge": -1, "formula": "C11H18NO8", "compartment": "p", "id": "acmum_p"}, {"name": "N-Acetylneuraminate", "notes": {"original_bigg_ids": ["acnam_c"]}, "charge": -1, "formula": "C11H18NO9", "compartment": "c", "id": "acnam_c"}, {"name": "N-Acetylneuraminate", "notes": {"original_bigg_ids": ["acnam_p"]}, "charge": -1, "formula": "C11H18NO9", "compartment": "p", "id": "acnam_p"}, {"name": "N-Acetyl-D-mannosamine", "notes": {"original_bigg_ids": ["acmana_c"]}, "charge": 0, "formula": "C8H15NO6", "compartment": "c", "id": "acmana_c"}, {"name": "Flavin adenine dinucleotide reduced", "notes": {"original_bigg_ids": ["fadh2_c"]}, "charge": -2, "formula": "C27H33N9O15P2", "compartment": "c", "id": "fadh2_c"}, {"name": "Crotonoyl-CoA", "notes": {"original_bigg_ids": ["b2coa_c"]}, "charge": -4, "formula": "C25H36N7O17P3S", "compartment": "c", "id": "b2coa_c"}, {"name": "Trans-Hex-2-enoyl-CoA", "notes": {"original_bigg_ids": ["hx2coa_c"]}, "charge": -4, "formula": "C27H40N7O17P3S", "compartment": "c", "id": "hx2coa_c"}, {"name": "Trans-Oct-2-enoyl-CoA", "notes": {"original_bigg_ids": ["oc2coa_c"]}, "charge": -4, "formula": "C29H44N7O17P3S", "compartment": "c", "id": "oc2coa_c"}, 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"maltpt_p"}, {"name": "Maltotriose", "notes": {"original_bigg_ids": ["malttr_p"]}, "charge": 0, "formula": "C18H32O16", "compartment": "p", "id": "malttr_p"}, {"name": "Maltotetraose", "notes": {"original_bigg_ids": ["maltttr_p"]}, "charge": 0, "formula": "C24H42O21", "compartment": "p", "id": "maltttr_p"}, {"name": "Maltose", "notes": {"original_bigg_ids": ["malt_p"]}, "charge": 0, "formula": "C12H22O11", "compartment": "p", "id": "malt_p"}, {"name": "Maltose 6'-phosphate", "notes": {"original_bigg_ids": ["malt6p_c"]}, "charge": -2, "formula": "C12H21O14P", "compartment": "c", "id": "malt6p_c"}, {"name": "L-Malate", "notes": {"original_bigg_ids": ["mal_DASH_L_p"]}, "charge": -2, "formula": "C4H4O5", "compartment": "p", "id": "mal__L_p"}, {"name": "D-Mannose 6-phosphate", "notes": {"original_bigg_ids": ["man6p_p"]}, "charge": -2, "formula": "C6H11O9P", "compartment": "p", "id": "man6p_p"}, {"name": "D-Mannonate", "notes": {"original_bigg_ids": ["mana_c"]}, "charge": -1, "formula": 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"formula": "C7H3NO4", "compartment": "c", "id": "quln_c"}, {"name": "Nitrite", "notes": {"original_bigg_ids": ["no2_c"]}, "charge": -1, "formula": "NO2", "compartment": "c", "id": "no2_c"}, {"name": "Nitrite", "notes": {"original_bigg_ids": ["no2_p"]}, "charge": -1, "formula": "NO2", "compartment": "p", "id": "no2_p"}, {"name": "Nitrate", "notes": {"original_bigg_ids": ["no3_p"]}, "charge": -1, "formula": "NO3", "compartment": "p", "id": "no3_p"}, {"name": "Nitrate", "notes": {"original_bigg_ids": ["no3_c"]}, "charge": -1, "formula": "NO3", "compartment": "c", "id": "no3_c"}, {"name": "Novobiocin", "notes": {"original_bigg_ids": ["novbcn_p"]}, "charge": 0, "formula": "C31H36N2O11", "compartment": "p", "id": "novbcn_p"}, {"name": "Nitric oxide", "notes": {"original_bigg_ids": ["no_p"]}, "charge": 0, "formula": "NO", "compartment": "p", "id": "no_p"}, {"name": "Xanthosine", "notes": {"original_bigg_ids": ["xtsn_c"]}, "charge": 0, "formula": "C10H12N4O6", "compartment": "c", "id": "xtsn_c"}, {"name": "Xanthosine 5'-phosphate", "notes": {"original_bigg_ids": ["xmp_p"]}, "charge": -2, "formula": "C10H11N4O9P", "compartment": "p", "id": "xmp_p"}, {"name": "Xanthosine", "notes": {"original_bigg_ids": ["xtsn_p"]}, "charge": 0, "formula": "C10H12N4O6", "compartment": "p", "id": "xtsn_p"}, {"name": "DIMP", "notes": {"original_bigg_ids": ["dimp_c"]}, "charge": -2, "formula": "C10H11N4O7P", "compartment": "c", "id": "dimp_c"}, {"name": "UMP", "notes": {"original_bigg_ids": ["ump_p"]}, "charge": -2, "formula": "C9H11N2O9P", "compartment": "p", "id": "ump_p"}, {"name": "Thymidine", "notes": {"original_bigg_ids": ["thymd_c"]}, "charge": 0, "formula": "C10H14N2O5", "compartment": "c", "id": "thymd_c"}, {"name": "Thymidine", "notes": {"original_bigg_ids": ["thymd_p"]}, "charge": 0, "formula": "C10H14N2O5", "compartment": "p", "id": "thymd_p"}, {"name": "DIDP", "notes": {"original_bigg_ids": ["didp_c"]}, "charge": -3, "formula": "C10H11N4O10P2", "compartment": "c", "id": "didp_c"}, {"name": "XDP", "notes": {"original_bigg_ids": ["xdp_c"]}, "charge": -3, "formula": "C10H11N4O12P2", "compartment": "c", "id": "xdp_c"}, {"name": "(O16 antigen)x4 core oligosaccharide lipid A", "notes": {"original_bigg_ids": ["o16a4colipa_p"]}, "charge": -11, "formula": "C312H523N6O200P4", "compartment": "p", "id": "o16a4colipa_p"}, {"name": "Rhamanosyl-N-acetylglucosamyl-undecaprenyl diphosphate", "notes": {"original_bigg_ids": ["ragund_c"]}, "charge": -2, "formula": "C69H113N1O16P2", "compartment": "c", "id": "ragund_c"}, {"name": "O-acetyl-rhamanosyl-N-acetylglucosamyl-undecaprenyl diphosphate", "notes": {"original_bigg_ids": ["aragund_c"]}, "charge": -2, "formula": "C71H115N1O17P2", "compartment": "c", "id": "aragund_c"}, {"name": "O16 antigen undecaprenyl diphosphate", "notes": {"original_bigg_ids": ["o16aund_c"]}, "charge": -2, "formula": "C89H145N1O32P2", "compartment": "c", "id": "o16aund_c"}, {"name": "Galactofuranosyl-glucosyl-O-acetyl-rhamanosyl-N-acetylglucosamyl-undecaprenyl diphosphate", "notes": {"original_bigg_ids": ["gfgaragund_c"]}, "charge": -2, "formula": "C83H135N1O27P2", "compartment": "c", "id": "gfgaragund_c"}, {"name": "Superoxide anion", "notes": {"original_bigg_ids": ["o2s_p"]}, "charge": -1, "formula": "O2", "compartment": "p", "id": "o2s_p"}, {"name": "3-Hydroxyglutaryl-[acyl-carrier protein] methyl ester", "notes": {"original_bigg_ids": ["hgmeACP_c"]}, "charge": -1, "formula": "C17H29N2O11PRS", "compartment": "c", "id": "hgmeACP_c"}, {"name": "3-Oxo-glutaryl-[acyl-carrier protein] methyl ester", "notes": {"original_bigg_ids": ["ogmeACP_c"]}, "charge": -1, "formula": "C17H27N2O11PRS", "compartment": "c", "id": "ogmeACP_c"}, {"name": "2-Oxo-3-hydroxy-4-phosphobutanoate", "notes": {"original_bigg_ids": ["ohpb_c"]}, "charge": -3, "formula": "C4H4O8P", "compartment": "c", "id": "ohpb_c"}, {"name": "2-Octaprenyl-6-methoxyphenol", "notes": {"original_bigg_ids": ["2omph_c"]}, "charge": 0, "formula": "C47H72O2", "compartment": "c", "id": "2omph_c"}, {"name": "2-Octaprenyl-6-methoxy-1,4-benzoquinol", "notes": {"original_bigg_ids": ["2ombzl_c"]}, "charge": 0, "formula": "C47H72O3", "compartment": "c", "id": "2ombzl_c"}, {"name": "2-Octaprenyl-3-methyl-6-methoxy- 1,4-benzoquinol", "notes": {"original_bigg_ids": ["2ommbl_c"]}, "charge": 0, "formula": "C48H74O3", "compartment": "c", "id": "2ommbl_c"}, {"name": "Orotidine 5'-phosphate", "notes": {"original_bigg_ids": ["orot5p_c"]}, "charge": -3, "formula": "C10H10N2O11P", "compartment": "c", "id": "orot5p_c"}, {"name": "2-Octaprenylphenol", "notes": {"original_bigg_ids": ["2oph_c"]}, "charge": 0, "formula": "C46H70O", "compartment": "c", "id": "2oph_c"}, {"name": "3-Hydroxypimeloyl-[acyl-carrier protein] methyl ester", "notes": {"original_bigg_ids": ["hpmeACP_c"]}, "charge": -1, "formula": "C19H33N2O11PRS", "compartment": "c", "id": "hpmeACP_c"}, {"name": "3-Oxo-pimeloyl-[acyl-carrier protein] methyl ester", "notes": {"original_bigg_ids": ["opmeACP_c"]}, "charge": -1, "formula": "C19H31N2O11PRS", "compartment": "c", "id": "opmeACP_c"}, {"name": "Orotate", "notes": {"original_bigg_ids": ["orot_p"]}, "charge": -1, "formula": "C5H3N2O4", "compartment": "p", "id": "orot_p"}, {"name": "Oxalureate", "notes": {"original_bigg_ids": ["oxur_c"]}, "charge": -1, "formula": "C3H3N2O4", "compartment": "c", "id": "oxur_c"}, {"name": "Phenylacetaldehyde", "notes": {"original_bigg_ids": ["pacald_c"]}, "charge": 0, "formula": "C8H8O", "compartment": "c", "id": "pacald_c"}, {"name": "Phenylacetaldehyde", "notes": {"original_bigg_ids": ["pacald_p"]}, "charge": 0, "formula": "C8H8O", "compartment": "p", "id": "pacald_p"}, {"name": "(R)-Pantothenate", "notes": {"original_bigg_ids": ["pnto_DASH_R_c"]}, "charge": -1, "formula": "C9H16NO5", "compartment": "c", "id": "pnto__R_c"}, {"name": "Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine", "notes": {"original_bigg_ids": ["uagmda_c"]}, "charge": -4, "formula": "C87H139N7O23P2", "compartment": "c", "id": "uagmda_c"}, {"name": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine", "notes": {"original_bigg_ids": ["ugmda_c"]}, "charge": -4, "formula": "C41H61N9O28P2", "compartment": "c", "id": "ugmda_c"}, {"name": "Pyridoxine 5'-phosphate", "notes": {"original_bigg_ids": ["pdx5p_c"]}, "charge": -2, "formula": "C8H10NO6P", "compartment": "c", "id": "pdx5p_c"}, {"name": "Pyridoxine", "notes": {"original_bigg_ids": ["pydxn_c"]}, "charge": 0, "formula": "C8H11NO3", "compartment": "c", "id": "pydxn_c"}, {"name": "Phosphatidylethanolamine (didodecanoyl, n-C12:0)", "notes": {"original_bigg_ids": ["pe120_p"]}, "charge": 0, "formula": "C29H58N1O8P1", "compartment": "p", "id": "pe120_p"}, {"name": "Phosphatidylethanolamine (ditetradecanoyl, n-C14:0)", "notes": {"original_bigg_ids": ["pe140_p"]}, "charge": 0, "formula": "C33H66N1O8P1", "compartment": "p", "id": "pe140_p"}, {"name": "Phosphatidylethanolamine (ditetradec-7-enoyl, n-C14:1)", "notes": {"original_bigg_ids": ["pe141_p"]}, "charge": 0, "formula": "C33H62N1O8P1", "compartment": "p", "id": "pe141_p"}, {"name": "Phosphatidylethanolamine (dioctadecanoyl, n-C18:0)", "notes": {"original_bigg_ids": ["pe180_p"]}, "charge": 0, "formula": "C41H82N1O8P1", "compartment": "p", "id": "pe180_p"}, {"name": "Phenethylamine", "notes": {"original_bigg_ids": ["peamn_p"]}, "charge": 1, "formula": "C8H12N", "compartment": "p", "id": "peamn_p"}, {"name": "D-Tagatose 1,6-biphosphate", "notes": {"original_bigg_ids": ["tagdp_DASH_D_c"]}, "charge": -4, "formula": "C6H10O12P2", "compartment": "c", "id": "tagdp__D_c"}, {"name": "Sedoheptulose 7-phosphate", "notes": {"original_bigg_ids": ["s7p_c"]}, "charge": -2, "formula": "C7H13O10P", "compartment": "c", "id": "s7p_c"}, {"name": "3-Phosphohydroxypyruvate", "notes": {"original_bigg_ids": ["3php_c"]}, "charge": -3, "formula": "C3H2O7P", "compartment": "c", "id": "3php_c"}, {"name": "2-Phosphoglycolate", "notes": {"original_bigg_ids": ["2pglyc_c"]}, "charge": -3, "formula": "C2H2O6P", "compartment": "c", "id": "2pglyc_c"}, {"name": "Phosphatidylglycerophosphate (didodecanoyl, n-C12:0)", "notes": {"original_bigg_ids": ["pgp120_p"]}, "charge": -3, "formula": "C30H57O13P2", "compartment": "p", "id": "pgp120_p"}, {"name": "Phosphatidylglycerophosphate (didodecanoyl, n-C12:0)", "notes": {"original_bigg_ids": ["pgp120_c"]}, "charge": -3, "formula": "C30H57O13P2", "compartment": "c", "id": "pgp120_c"}, {"name": "Phosphatidylglycerophosphate (ditetradecanoyl, n-C14:0)", "notes": {"original_bigg_ids": ["pgp140_p"]}, "charge": -3, "formula": "C34H65O13P2", "compartment": "p", "id": "pgp140_p"}, {"name": "Phosphatidylglycerophosphate (ditetradecanoyl, n-C14:0)", "notes": {"original_bigg_ids": ["pgp140_c"]}, "charge": -3, "formula": "C34H65O13P2", "compartment": "c", "id": "pgp140_c"}, {"name": "Phosphatidylglycerophosphate (ditetradec-7-enoyl, n-C14:1)", "notes": {"original_bigg_ids": ["pgp141_p"]}, "charge": -3, "formula": "C34H61O13P2", "compartment": "p", "id": "pgp141_p"}, {"name": "Phosphatidylglycerophosphate (ditetradec-7-enoyl, n-C14:1)", "notes": {"original_bigg_ids": ["pgp141_c"]}, "charge": -3, "formula": "C34H61O13P2", "compartment": "c", "id": "pgp141_c"}, {"name": "Phosphatidylglycerophosphate (dihexadecanoyl, n-C16:0)", "notes": {"original_bigg_ids": ["pgp160_p"]}, "charge": -3, "formula": "C38H73O13P2", "compartment": "p", "id": "pgp160_p"}, {"name": "Phosphatidylglycerophosphate (dihexadecanoyl, n-C16:0)", "notes": {"original_bigg_ids": ["pgp160_c"]}, "charge": -3, "formula": "C38H73O13P2", "compartment": "c", "id": "pgp160_c"}, {"name": "Phosphatidylglycerophosphate (dihexadec-9-enoyl, n-C16:1)", "notes": {"original_bigg_ids": ["pgp161_p"]}, "charge": -3, "formula": "C38H69O13P2", "compartment": "p", "id": "pgp161_p"}, {"name": "Phosphatidylglycerophosphate (dihexadec-9-enoyl, n-C16:1)", "notes": {"original_bigg_ids": ["pgp161_c"]}, "charge": -3, "formula": "C38H69O13P2", "compartment": "c", "id": "pgp161_c"}, {"name": "Phosphatidylglycerophosphate (dioctadecanoyl, n-C18:0)", "notes": {"original_bigg_ids": ["pgp180_c"]}, "charge": -3, "formula": "C42H81O13P2", "compartment": "c", "id": "pgp180_c"}, {"name": "Phosphatidylglycerophosphate (dioctadecanoyl, n-C18:0)", "notes": {"original_bigg_ids": ["pgp180_p"]}, "charge": -3, "formula": "C42H81O13P2", "compartment": "p", "id": "pgp180_p"}, {"name": "Phosphatidylglycerophosphate (dioctadec-11-enoyl, n-C18:1)", "notes": {"original_bigg_ids": ["pgp181_p"]}, "charge": -3, "formula": "C42H77O13P2", "compartment": "p", "id": "pgp181_p"}, {"name": "Phosphatidylglycerophosphate (dioctadec-11-enoyl, n-C18:1)", "notes": {"original_bigg_ids": ["pgp181_c"]}, "charge": -3, "formula": "C42H77O13P2", "compartment": "c", "id": "pgp181_c"}, {"name": "Protoheme", "notes": {"original_bigg_ids": ["pheme_p"]}, "charge": -2, "formula": "C34H30FeN4O4", "compartment": "p", "id": "pheme_p"}, {"name": "Phenylpyruvate", "notes": {"original_bigg_ids": ["phpyr_c"]}, "charge": -1, "formula": "C9H7O3", "compartment": "c", "id": "phpyr_c"}, {"name": "TRNA(Phe)", "notes": {"original_bigg_ids": ["trnaphe_c"]}, "charge": 0, "formula": "R", "compartment": "c", "id": "trnaphe_c"}, {"name": "L-Phenylalanyl-tRNA(Phe)", "notes": {"original_bigg_ids": ["phetrna_c"]}, "charge": 1, "formula": "C9H10NOR", "compartment": "c", "id": "phetrna_c"}, {"name": "L-Phenylalanine", "notes": {"original_bigg_ids": ["phe_DASH_L_p"]}, "charge": 0, "formula": "C9H11NO2", "compartment": "p", "id": "phe__L_p"}, {"name": "4-(1-D-Ribitylamino)-5-aminouracil", "notes": {"original_bigg_ids": ["4r5au_c"]}, "charge": 0, "formula": "C9H16N4O6", "compartment": "c", "id": "4r5au_c"}, {"name": "D-4'-Phosphopantothenate", "notes": {"original_bigg_ids": ["4ppan_c"]}, "charge": -3, "formula": "C9H15NO8P", "compartment": "c", "id": "4ppan_c"}, {"name": "(R)-Pantothenate", "notes": {"original_bigg_ids": ["pnto_DASH_R_p"]}, "charge": -1, "formula": "C9H16NO5", "compartment": "p", "id": "pnto__R_p"}, {"name": "Peroxyaminoacrylate", "notes": {"original_bigg_ids": ["poaac_c"]}, "charge": 0, "formula": "C3H5NO3", "compartment": "c", "id": "poaac_c"}, {"name": "Propanoyl phosphate", "notes": {"original_bigg_ids": ["ppap_c"]}, "charge": -2, "formula": "C3H5O5P", "compartment": "c", "id": "ppap_c"}, {"name": "Propanal", "notes": {"original_bigg_ids": ["ppal_p"]}, "charge": 0, "formula": "C3H6O", "compartment": "p", "id": "ppal_p"}, {"name": "Propionate (n-C3:0)", "notes": {"original_bigg_ids": ["ppa_p"]}, "charge": -1, "formula": "C3H5O2", "compartment": "p", "id": "ppa_p"}, {"name": "Pantetheine 4'-phosphate", "notes": {"original_bigg_ids": ["pan4p_c"]}, "charge": -2, "formula": "C11H21N2O7PS", "compartment": "c", "id": "pan4p_c"}, {"name": "N-((R)-4-Phosphopantothenoyl)-L-cysteine", "notes": {"original_bigg_ids": ["4ppcys_c"]}, "charge": -3, "formula": "C12H20N2O9PS", "compartment": "c", "id": "4ppcys_c"}, {"name": "Alpha-D-Ribose 1-phosphate", "notes": {"original_bigg_ids": ["r1p_c"]}, "charge": -2, "formula": "C5H9O8P", "compartment": "c", "id": "r1p_c"}, {"name": "3-(4-Hydroxyphenyl)pyruvate", "notes": {"original_bigg_ids": ["34hpp_c"]}, "charge": -1, "formula": "C9H7O4", "compartment": "c", "id": "34hpp_c"}, {"name": "Phenylpropanoate", "notes": {"original_bigg_ids": ["pppn_c"]}, "charge": -1, "formula": "C9H9O2", "compartment": "c", "id": "pppn_c"}, {"name": "Phenylpropanoate", "notes": {"original_bigg_ids": ["pppn_p"]}, "charge": -1, "formula": "C9H9O2", "compartment": "p", "id": "pppn_p"}, {"name": "Phosphonate", "notes": {"original_bigg_ids": ["ppt_p"]}, "charge": -2, "formula": "HO3P", "compartment": "p", "id": "ppt_p"}, {"name": "2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine", "notes": {"original_bigg_ids": ["fpram_c"]}, "charge": -1, "formula": "C8H15N3O8P", "compartment": "c", "id": "fpram_c"}, {"name": "1-(5-Phosphoribosyl)-AMP", "notes": 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{"original_bigg_ids": ["AEP_e"]}, "charge": -1, "formula": "C2H7N1O3P1", "compartment": "e", "id": "AEP_e"}, {"name": "Oxaloacetate", "notes": {"original_bigg_ids": ["oaa_p"]}, "charge": -2, "formula": "C4H2O5", "compartment": "p", "id": "oaa_p"}, {"name": "Tetrathionate", "notes": {"original_bigg_ids": ["tet_p"]}, "charge": -2, "formula": "O6S4", "compartment": "p", "id": "tet_p"}, {"name": "Pseudouridine 5  phosphate C9H11N2O9P", "notes": {"original_bigg_ids": ["psd5p_c"]}, "charge": -2, "formula": "C9H13N2O9P", "compartment": "c", "id": "psd5p_c"}, {"name": "O-antigen-x20-core-oligosaccharide-lipid-A", "notes": {"original_bigg_ids": ["colipa20Oag_e"]}, "charge": -11, "formula": "C656H1103N2O440P4", "compartment": "e", "id": "colipa20Oag_e"}, {"name": "D-biotin d-sulfoxide", "notes": {"original_bigg_ids": ["btnso_c"]}, "charge": -1, "formula": "C10H15N2O4S", "compartment": "c", "id": "btnso_c"}, {"name": "2-3-dihydroxybenzoylserine trimer", "notes": {"original_bigg_ids": ["23dhbzs3_c"]}, "charge": 0, "formula": "C30H29N3O16", "compartment": "c", "id": "23dhbzs3_c"}, {"name": "Residual-atoms-of-reaction-DMBZIDSYN", "notes": {"original_bigg_ids": ["remnant1_e"]}, "charge": 0, "formula": "C4H2N2O3", "compartment": "e", "id": "remnant1_e"}, {"name": "D-Tagatose", "notes": {"original_bigg_ids": ["tag_DASH_D_p"]}, "charge": 0, "formula": "C6H12O6", "compartment": "p", "id": "tag__D_p"}, {"name": "N Ribosylnicotinamide C11H15N2O5", "notes": {"original_bigg_ids": ["rnam_e"]}, "charge": 1, "formula": "C11H15N2O5", "compartment": "e", "id": "rnam_e"}, {"name": "Cis-Aconitate", "notes": {"original_bigg_ids": ["acon_DASH_C_p"]}, "charge": -3, "formula": "C6H3O6", "compartment": "p", "id": "acon_C_p"}, {"name": "Adenosylcobalamin-phosphate", "notes": {"original_bigg_ids": ["adocblp_c"]}, "charge": -2, "formula": "C72H99CoN18O20P2", "compartment": "c", "id": "adocblp_c"}, {"name": "Cobalt-precorrin-2", "notes": {"original_bigg_ids": ["codscl2_c"]}, "charge": -7, "formula": "C42H39CoN4O16", "compartment": "c", "id": "codscl2_c"}, {"name": "Aminoimidazole-riboside", "notes": {"original_bigg_ids": ["airs_e"]}, "charge": 0, "formula": "C8H13N3O4", "compartment": "e", "id": "airs_e"}, {"name": "2-Aminoethylphosphonate", "notes": {"original_bigg_ids": ["AEP_p"]}, "charge": -1, "formula": "C2H7N1O3P1", "compartment": "p", "id": "AEP_p"}, {"name": "Undecaprenyl diphosphate galactose-rhamnose-mannose-abequose", "notes": {"original_bigg_ids": ["udcpo4_e"]}, "charge": -2, "formula": "C79H132O24P2", "compartment": "e", "id": "udcpo4_e"}, {"name": "Ferrioxamine-G-fe", "notes": {"original_bigg_ids": ["feroxGfe_e"]}, "charge": 0, "formula": "C27H46FeN6O10", "compartment": "e", "id": "feroxGfe_e"}, {"name": "Salmochelin-S2-Fe-III", "notes": {"original_bigg_ids": ["salchs2fe_c"]}, "charge": 0, "formula": "C42FeH49N3O26", "compartment": "c", "id": "salchs2fe_c"}, {"name": "Salmochelin-S2-Fe-III", "notes": {"original_bigg_ids": ["salchs2fe_p"]}, "charge": 0, "formula": "C42FeH49N3O26", "compartment": "p", "id": "salchs2fe_p"}, {"name": "Undecaprenyl diphosphate galactose-rhamnose-mannose-abequose-acetyl", "notes": {"original_bigg_ids": ["udcpo5_e"]}, "charge": -2, "formula": "C81H134O25P2", "compartment": "e", "id": "udcpo5_e"}, {"name": "Ferrioxamine-G", "notes": {"original_bigg_ids": ["feroxG_e"]}, "charge": 0, "formula": "C27H46N6O10", "compartment": "e", "id": "feroxG_e"}, {"name": "Formamide", "notes": {"original_bigg_ids": ["foam_p"]}, "charge": 0, "formula": "CH3NO", "compartment": "p", "id": "foam_p"}, {"name": "4-Hydroxy-benzyl alcohol", "notes": {"original_bigg_ids": ["4hba_c"]}, "charge": 0, "formula": "C7H8O2", "compartment": "c", "id": "4hba_c"}, {"notes": {"original_bigg_ids": ["diact_e"]}, "compartment": "e", "name": "Diacetyl", "charge": 0, "id": "diact_e"}, {"notes": {"original_bigg_ids": ["indpyr_c"]}, "compartment": "c", "name": "Indolepyruvate C11H8NO3", "charge": 0, "id": "indpyr_c"}, {"notes": {"original_bigg_ids": ["pprdn_c"]}, "compartment": "c", "name": "Piperideine", "charge": 0, "id": "pprdn_c"}, {"notes": {"original_bigg_ids": ["5aptn_c"]}, "compartment": "c", "name": "5-Aminopentanoate", "charge": 0, "id": "5aptn_c"}, {"notes": {"original_bigg_ids": ["cellb_e"]}, "compartment": "e", "name": "Cellobiose", "charge": 0, "id": "cellb_e"}, {"notes": {"original_bigg_ids": ["btd_DASH_RR_e"]}, "compartment": "e", "name": " R R  2 3 Butanediol C4H10O2", "charge": 0, "id": "btd_RR_e"}, {"notes": {"original_bigg_ids": ["13ppd_e"]}, "compartment": "e", "name": "1,3-Propanediol", "charge": 0, "id": "13ppd_e"}, {"notes": {"original_bigg_ids": ["rbt_e"]}, "compartment": "e", "name": "Ribitol", "charge": 0, "id": "rbt_e"}, {"notes": {"original_bigg_ids": ["glutar_c"]}, "compartment": "c", "name": "Glutarate", "charge": 0, "id": "glutar_c"}, {"notes": {"original_bigg_ids": ["oxptn_c"]}, "compartment": "c", "name": "5-Oxopentanoate", "charge": 0, "id": "oxptn_c"}, {"notes": {"original_bigg_ids": ["bz_e"]}, "compartment": "e", "name": "Benzoate", "charge": 0, "id": "bz_e"}, {"name": "3-Oxoadipyl-CoA", "notes": {"original_bigg_ids": ["oxadpcoa_c"]}, "charge": -5, "formula": "C27H37N7O20P3S", "compartment": "c", "id": "oxadpcoa_c"}, {"notes": {"original_bigg_ids": ["glutcoa_c"]}, "compartment": "c", "name": "Glutaryl-CoA", "charge": 0, "id": "glutcoa_c"}, {"notes": {"original_bigg_ids": ["abt_DASH_D_e"]}, "compartment": "e", "name": "D-Arabitol", "charge": 0, "id": "abt__D_e"}, {"name": "4-Hydroxyphenylacetate", "notes": {"original_bigg_ids": ["4hphac_p"]}, "charge": -1, "formula": "C8H7O3", "compartment": "p", "id": "4hphac_p"}, {"notes": {"original_bigg_ids": ["4hphac_c"]}, "compartment": "c", "name": "4-Hydroxyphenylacetate", "charge": 0, "id": "4hphac_c"}, {"name": "Cyanate", "notes": {"original_bigg_ids": ["cynt_c"]}, "charge": -1, "formula": "CNO", "compartment": "c", "id": "cynt_c"}, {"name": "S-Methyl-L-methionine", "notes": {"original_bigg_ids": ["mmet_c"]}, "charge": 1, "formula": "C6H14NO2S", "compartment": "c", "id": "mmet_c"}, {"name": "Salicylate", "notes": {"original_bigg_ids": ["salc_c"]}, "charge": 0, "formula": "C7H5O3", "compartment": "c", "id": "salc_c"}, {"name": "2(alpha-D-Mannosyl-6-phosphate)-D-glycerate", "notes": {"original_bigg_ids": ["man6pglyc_c"]}, "charge": -3, "formula": "C9H14O12P", "compartment": "c", "id": "man6pglyc_c"}, {"name": "Fe p", "notes": {"original_bigg_ids": ["fe_e"]}, "charge": 0, "formula": "Fe", "compartment": "e", "id": "fe_e"}, {"name": "Fe p", "notes": {"original_bigg_ids": ["fe_p"]}, "charge": 0, "formula": "Fe", "compartment": "p", "id": "fe_p"}, {"name": "Fe p", "notes": {"original_bigg_ids": ["fe_c"]}, "charge": 0, "formula": "Fe", "compartment": "c", "id": "fe_c"}, {"name": "Psicoselysine", "notes": {"original_bigg_ids": ["psclys_c"]}, "charge": 1, "formula": "C12H25N2O7", "compartment": "c", "id": "psclys_c"}, {"name": "3-(3-hydroxy-phenyl)propionate", "notes": {"original_bigg_ids": ["3hpppn_c"]}, "charge": -1, "formula": "C9H9O3", "compartment": "c", "id": "3hpppn_c"}, {"name": "3-hydroxycinnamic acid", "notes": {"original_bigg_ids": ["3hcinnm_c"]}, "charge": -1, "formula": "C9H7O3", "compartment": "c", "id": "3hcinnm_c"}, {"name": "KO-KDO-LIPID A", "notes": {"original_bigg_ids": ["kokdolipidA_e"]}, "charge": 0, "formula": "C110H196N2O40P2", "compartment": "e", "id": "kokdolipidA_e"}, {"name": "D Galactosamine 6 phosphate C6H14NO8P", "notes": {"original_bigg_ids": ["galam6p_c"]}, "charge": 0, "formula": "C6H14NO8P", "compartment": "c", "id": "galam6p_c"}, {"name": "Salicin", "notes": {"original_bigg_ids": ["salcn_c"]}, "charge": 0, "formula": "C13H18O7", "compartment": "c", "id": "salcn_c"}, {"name": "2-(Hydroxymethyl)phenol", "notes": {"original_bigg_ids": ["2hymeph_c"]}, "charge": 0, "formula": "C7H8O2", "compartment": "c", "id": "2hymeph_c"}, {"name": "Cellobiose", "notes": {"original_bigg_ids": ["cellb_p"]}, "charge": 0, "formula": "C12H22O11", "compartment": "p", "id": "cellb_p"}, {"name": "3 Hydroxyphenylacetic acid C8H8O3", "notes": {"original_bigg_ids": ["3hoxpac_e"]}, "charge": 0, "formula": "C8H8O3", "compartment": "e", "id": "3hoxpac_e"}, {"name": "Penicillin G C16H18N2O4S", "notes": {"original_bigg_ids": ["peng_e"]}, "charge": 0, "formula": "C16H18N2O4S", "compartment": "e", "id": "peng_e"}, {"name": "Penicillin G C16H18N2O4S", "notes": {"original_bigg_ids": ["peng_p"]}, "charge": 0, "formula": "C16H18N2O4S", "compartment": "p", "id": "peng_p"}, {"name": " O6 antigen x4 core oligosaccharide lipid A O225H390N2O120P2", "notes": {"original_bigg_ids": ["o6a4colipa_e"]}, "charge": 0, "formula": "O225H390N2O120P2", "compartment": "e", "id": "o6a4colipa_e"}, {"name": "D Galactosamine C6H13NO5", "notes": {"original_bigg_ids": ["galam_p"]}, "charge": 0, "formula": "C6H13NO5", "compartment": "p", "id": "galam_p"}, {"name": "R1 glucosyl inner core oligosaccharide lipid A with laurate C135H216N2O68P4", "notes": {"original_bigg_ids": ["gicolipaBR1_c"]}, "charge": 0, "formula": "C135H216N2O68P4", "compartment": "c", "id": "gicolipaBR1_c"}, {"name": "R1 glucosyl glucosyl inner core oligosaccharide lipid A with laurate C141H226N2O73P4", "notes": {"original_bigg_ids": ["ggicolipaBR1_c"]}, "charge": 0, "formula": "C141H226N2O73P4", "compartment": "c", "id": "ggicolipaBR1_c"}, {"name": "3 Hydroxyphenylacetic acid C8H8O3", "notes": {"original_bigg_ids": ["3hoxpac_p"]}, "charge": 0, "formula": "C8H8O3", "compartment": "p", "id": "3hoxpac_p"}, {"name": "6 Aminopenicillanic acid C8H12N2O3S", "notes": {"original_bigg_ids": ["6apa_p"]}, "charge": 0, "formula": "C8H12N2O3S", "compartment": "p", "id": "6apa_p"}, {"name": "6 Aminopenicillanic acid C8H12N2O3S", "notes": {"original_bigg_ids": ["6apa_e"]}, "charge": 0, "formula": "C8H12N2O3S", "compartment": "e", "id": "6apa_e"}, {"name": "(R)-Methylmalonyl-CoA", "notes": {"original_bigg_ids": ["mmcoa_R_c"]}, "charge": 0, "formula": "C25H35N7O19P3S", "compartment": "c", "id": "mmcoa__R_c"}, {"name": "D Galactosamine C6H13NO5", "notes": {"original_bigg_ids": ["galam_e"]}, "charge": 0, "formula": "C6H13NO5", "compartment": "e", "id": "galam_e"}, {"name": "Core oligosaccharide lipid A with laurate C159H256N2O88P4", "notes": {"original_bigg_ids": ["colipaB_c"]}, "charge": 0, "formula": "C159H256N2O88P4", "compartment": "c", "id": "colipaB_c"}, {"name": "R1 galactosyl glucosyl glucosyl glucosyl inner core oligosaccharide lipid A with laurate C153H246N2O83P4", "notes": {"original_bigg_ids": ["gagggicolipaBR1_c"]}, "charge": 0, "formula": "C153H246N2O83P4", "compartment": "c", "id": "gagggicolipaBR1_c"}, {"name": "R1 glucosyl glucosyl glucosyl inner core oligosaccharide lipid A with laurate C147H236N2O78P4", "notes": {"original_bigg_ids": ["gggicolipaBR1_c"]}, "charge": 0, "formula": "C147H236N2O78P4", "compartment": "c", "id": "gggicolipaBR1_c"}, {"name": "R1 inner core oligosaccharide lipid A  E coli  with laurate C129H206N2O63P4", "notes": {"original_bigg_ids": ["icolipaBR1_c"]}, "charge": 0, "formula": "C129H206N2O63P4", "compartment": "c", "id": "icolipaBR1_c"}, {"name": "Heptosyl phospho heptosyl heptosyl kdo2 lipidA with laurate C122H195N2O54P3", "notes": {"original_bigg_ids": ["hphhlipaB_c"]}, "charge": 0, "formula": "C122H195N2O54P3", "compartment": "c", "id": "hphhlipaB_c"}, {"notes": {"original_bigg_ids": ["LptA_p"]}, "compartment": "p", "name": "Periplasmic lipid A binding protein ", "charge": 0, "id": "LptA_p"}, {"name": "1' Phosphoethanolamin lipidIVa C70H132N3O26P3", "notes": {"original_bigg_ids": ["enlipidA_p"]}, "charge": 0, "formula": "C70H132N3O26P3", "compartment": "p", "id": "enlipidA_p"}, {"name": "1' Phosphoethanolamin lipidIVa C70H132N3O26P3", "notes": {"original_bigg_ids": ["enlipidA_LptA_p"]}, "charge": 0, "formula": "C70H132N3O26P3", "compartment": "p", "id": "enlipidA_LptA_p"}, {"name": "3 Nitrotyramine C8H15N2", "notes": {"original_bigg_ids": ["3ntym_e"]}, "charge": 0, "formula": "C8H15N2", "compartment": "e", "id": "3ntym_e"}, {"name": "Salicin", "notes": {"original_bigg_ids": ["salcn_p"]}, "charge": 0, "formula": "C13H18O7", "compartment": "p", "id": "salcn_p"}, {"name": "Salicin", "notes": {"original_bigg_ids": ["salcn_e"]}, "charge": 0, "formula": "C13H18O7", "compartment": "e", "id": "salcn_e"}, {"name": "Cellobiose 6 phosphate C12H21O14P", "notes": {"original_bigg_ids": ["cellb6p_c"]}, "charge": 0, "formula": "C12H21O14P", "compartment": "c", "id": "cellb6p_c"}, {"name": "1' Phosphoethanolamin lipidIVa C70H132N3O26P3", "notes": {"original_bigg_ids": ["enlipidA_e"]}, "charge": 0, "formula": "C70H132N3O26P3", "compartment": "e", "id": "enlipidA_e"}, {"name": "4 Hydroxyphenylacetic acid C8H8O3", "notes": {"original_bigg_ids": ["4hoxpac_e"]}, "charge": 0, "formula": "C8H8O3", "compartment": "e", "id": "4hoxpac_e"}, {"name": "Phenylacetic acid", "notes": {"original_bigg_ids": ["pac_e"]}, "charge": 0, "formula": "C8H7O2", "compartment": "e", "id": "pac_e"}, {"name": "N Acetyl D galactosamine 6 phosphate C8H16NO9P", "notes": {"original_bigg_ids": ["acgal6p_c"]}, "charge": 0, "formula": "C8H16NO9P", "compartment": "c", "id": "acgal6p_c"}, {"name": "Salicin 6 phosphate C13H19O10P", "notes": {"original_bigg_ids": ["salcn6p_c"]}, "charge": 0, "formula": "C13H19O10P", "compartment": "c", "id": "salcn6p_c"}, {"name": "R1 inner core oligosaccharide lipid A  E coli  C131H210N2O63P4", "notes": {"original_bigg_ids": ["icolipaAR1_c"]}, "charge": 0, "formula": "C131H210N2O63P4", "compartment": "c", "id": "icolipaAR1_c"}, {"name": "Heptosyl phospho heptosyl heptosyl kdo2 lipidA C131H211N2O60P3", "notes": {"original_bigg_ids": ["hphhlipaA_c"]}, "charge": 0, "formula": "C131H211N2O60P3", "compartment": "c", "id": "hphhlipaA_c"}, {"name": "R1 glucosyl inner core oligosaccharide lipid A C137H220N2O68P4", "notes": {"original_bigg_ids": ["gicolipaAR1_c"]}, "charge": 0, "formula": "C137H220N2O68P4", "compartment": "c", "id": "gicolipaAR1_c"}, {"name": "R1 glucosyl glucosyl inner core oligosaccharide lipid A C143H230N2O73P4", "notes": {"original_bigg_ids": ["ggicolipaAR1_c"]}, "charge": 0, "formula": "C143H230N2O73P4", "compartment": "c", "id": "ggicolipaAR1_c"}, {"name": "Cellobiose", "notes": {"original_bigg_ids": ["cellb_c"]}, "charge": 0, "formula": "C12H22O11", "compartment": "c", "id": "cellb_c"}, {"name": "Raffinose C18H32O16", "notes": {"original_bigg_ids": ["raffin_e"]}, "charge": 0, "formula": "C18H32O16", "compartment": "e", "id": "raffin_e"}, {"name": "2 3 2'3' Tetrakis beta hydroxymyristoyl  D glucosaminyl 1 6 beta D glucosamine 1 4' bisphosphate C68H126N2O23P2", "notes": {"original_bigg_ids": ["lipidA_core_e_p"]}, "charge": 0, "formula": "C68H126N2O23P2", "compartment": "p", "id": "lipidA_core_e_p"}, {"name": "Phenylacetic acid", "notes": {"original_bigg_ids": ["pac_p"]}, "charge": 0, "formula": "C8H7O2", "compartment": "p", "id": "pac_p"}, {"name": "Core oligosaccharide lipid A C161H260N2O88P4", "notes": {"original_bigg_ids": ["colipaA_c"]}, "charge": 0, "formula": "C161H260N2O88P4", "compartment": "c", "id": "colipaA_c"}, {"name": "R1 galactosyl glucosyl glucosyl glucosyl inner core oligosaccharide lipid A C155H250N2O83P4", "notes": {"original_bigg_ids": ["gagggicolipaAR1_c"]}, "charge": 0, "formula": "C155H250N2O83P4", "compartment": "c", "id": "gagggicolipaAR1_c"}, {"name": "R1 glucosyl glucosyl glucosyl inner core oligosaccharide lipid A C149H240N2O78P4", "notes": {"original_bigg_ids": ["gggicolipaAR1_c"]}, "charge": 0, "formula": "C149H240N2O78P4", "compartment": "c", "id": "gggicolipaAR1_c"}, {"name": "Raffinose C18H32O16", "notes": {"original_bigg_ids": ["raffin_p"]}, "charge": 0, "formula": "C18H32O16", "compartment": "p", "id": "raffin_p"}, {"name": "D Arabinose C5H10O5", "notes": {"original_bigg_ids": ["arab_DASH_D_c"]}, "charge": 0, "formula": "C5H10O5", "compartment": "c", "id": "arab__D_c"}, {"name": "D Arabinose C5H10O5", "notes": {"original_bigg_ids": ["arab_DASH_D_p"]}, "charge": 0, "formula": "C5H10O5", "compartment": "p", "id": "arab__D_p"}, {"name": "D-Ribulose", "notes": {"original_bigg_ids": ["rbl_DASH_D_c"]}, "charge": 0, "formula": "C5H10O5", "compartment": "c", "id": "rbl__D_c"}, {"name": "D Arabinose C5H10O5", "notes": {"original_bigg_ids": ["arab_DASH_D_e"]}, "charge": 0, "formula": "C5H10O5", "compartment": "e", "id": "arab__D_e"}, {"notes": {"original_bigg_ids": ["cdigmp_c"]}, "compartment": "c", "name": "Cyclic diguanosine monophosphate", "charge": 0, "id": "cdigmp_c"}, {"notes": {"original_bigg_ids": ["dkfp_c"]}, "compartment": "c", "name": "6-deoxy-5-ketofructose 1-phosphate", "charge": 0, "id": "dkfp_c"}, {"name": "Phospho-heptosyl-phospho-heptosyl-heptosyl-kdo2-lipidA", "notes": {"original_bigg_ids": ["phphhlipa_c"]}, "charge": -10, "formula": "C131H230N2O63P4", "compartment": "c", "id": "phphhlipa_c"}, {"name": "Glucosyl-galactosyl-glucosyl-inner core oligosaccharide lipid A", "notes": {"original_bigg_ids": ["ggagicolipa_c"]}, "charge": -11, "formula": "C163H281N2O89P4", "compartment": "c", "id": "ggagicolipa_c"}, {"name": "Galactosyl-glucosyl-inner core oligosaccharide lipid A", "notes": {"original_bigg_ids": ["gagicolipa_c"]}, "charge": -11, "formula": "C157H271N2O84P4", "compartment": "c", "id": "gagicolipa_c"}, {"name": "2,3-dehydroadipyl-CoA", "notes": {"original_bigg_ids": ["23dhacoa_c"]}, "charge": -5, "formula": "C27H37N7O19P3S", "compartment": "c", "id": "23dhacoa_c"}, {"name": "(3S)-3-Hydroxyadipyl-CoA", "notes": {"original_bigg_ids": ["3hadpcoa_c"]}, "charge": -5, "formula": "C27H39N7O20P3S", "compartment": "c", "id": "3hadpcoa_c"}, {"notes": {"original_bigg_ids": ["srb1p_c"]}, "compartment": "c", "name": "Sorbose 1-phosphate", "charge": 0, "id": "srb1p_c"}, {"notes": {"original_bigg_ids": ["gggagicolipa_c"]}, "compartment": "c", "name": "Glucosyl-glucosyl-galactosyl-glucosyl-inner core oligosaccharide lipid A", "charge": 0, "id": "gggagicolipa_c"}, {"notes": {"original_bigg_ids": ["cmp_DASH_nate_c"]}, "compartment": "c", "name": "CMP-N-acetylneuraminate", "charge": -2, "id": "cmp_nate_c"}, {"notes": {"original_bigg_ids": ["nicrns_c"]}, "compartment": "c", "name": "Nicotinate D-ribonucleoside", "charge": 0, "id": "nicrns_c"}, {"notes": {"original_bigg_ids": ["2ombz_c"]}, "compartment": "c", "name": "2-Octaprenyl-6-methoxy-1,4-benzoquinone", "charge": 0, "id": "2ombz_c"}, {"notes": {"original_bigg_ids": ["2ommb_c"]}, "compartment": "c", "name": "2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone", "charge": 0, "id": "2ommb_c"}, {"notes": {"original_bigg_ids": ["ah6p_DASH_D_c"]}, "compartment": "c", "name": "Arabino-3-hexulose-6-P", "charge": 0, "id": "ah6p__D_c"}, {"notes": {"original_bigg_ids": ["3hmp_c"]}, "compartment": "c", "name": "3-Hydroxy-2-methylpropanoate", "charge": 0, "id": "3hmp_c"}, {"notes": {"original_bigg_ids": ["3hibutcoa_c"]}, "compartment": "c", "name": "(S)-3-Hydroxyisobutyryl-CoA", "charge": 0, "id": "3hibutcoa_c"}, {"notes": {"original_bigg_ids": ["lpam_c"]}, "compartment": "c", "name": "Lipoamide C8H15NOS2", "charge": 0, "id": "lpam_c"}, {"notes": {"original_bigg_ids": ["dhlam_c"]}, "compartment": "c", "name": "Dihydrolipoamide C8H17NOS2", "charge": 0, "id": "dhlam_c"}, {"notes": {"original_bigg_ids": ["2hyoxplac_c"]}, "compartment": "c", "name": "2-Hydroxyphenylacetate", "charge": 0, "id": "2hyoxplac_c"}, {"notes": {"original_bigg_ids": ["6pgg_c"]}, "compartment": "c", "name": "6pgg c", "charge": 0, "id": "6pgg_c"}, {"notes": {"original_bigg_ids": ["36dahx_c"]}, "compartment": "c", "name": "(3S)-3,6-Diaminohexanoate", "charge": 0, "id": "36dahx_c"}], "version": 1, "id": "iECS88_1305"}