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{"arbt_e": -1.0}, "id": "EX_arbt_e", "gene_reaction_rule": ""}, {"name": "Aerobactin minus Fe3 exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_arbtn_LPAREN_e_RPAREN_"]}, "metabolites": {"arbtn_e": -1.0}, "id": "EX_arbtn_e", "gene_reaction_rule": ""}, {"name": "Aerobactin exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_arbtn_DASH_fe3_LPAREN_e_RPAREN_"]}, "metabolites": {"arbtn_fe3_e": -1.0}, "id": "EX_arbtn_fe3_e", "gene_reaction_rule": ""}, {"name": "L-Arginine exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_arg_DASH_L_LPAREN_e_RPAREN_"]}, "metabolites": {"arg__L_e": -1.0}, "id": "EX_arg__L_e", "gene_reaction_rule": ""}, {"name": "L-Ascorbate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_ascb_DASH_L_LPAREN_e_RPAREN_"]}, "metabolites": {"ascb__L_e": -1.0}, "id": "EX_ascb__L_e", "gene_reaction_rule": ""}, {"name": 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"Fe(III)hydroxamate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_fe3hox_LPAREN_e_RPAREN_"]}, "metabolites": {"fe3hox_e": -1.0}, "id": "EX_fe3hox_e", "gene_reaction_rule": ""}, {"name": "Fe(III)hydoxamate, unloaded exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_fe3hox_DASH_un_LPAREN_e_RPAREN_"]}, "metabolites": {"fe3hox_un_e": -1.0}, "id": "EX_fe3hox_un_e", "gene_reaction_rule": ""}, {"name": "Ferrichrome exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_fecrm_LPAREN_e_RPAREN_"]}, "metabolites": {"fecrm_e": -1.0}, "id": "EX_fecrm_e", "gene_reaction_rule": ""}, {"name": "Ferrichrome minus Fe(III) exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_fecrm_DASH_un_LPAREN_e_RPAREN_"]}, "metabolites": {"fecrm_un_e": -1.0}, "id": "EX_fecrm_un_e", "gene_reaction_rule": ""}, {"name": "Fe-enterobactin exchange", "upper_bound": 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["EX_lcts_LPAREN_e_RPAREN_"]}, "metabolites": {"lcts_e": -1.0}, "id": "EX_lcts_e", "gene_reaction_rule": ""}, {"name": "L-Leucine exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_leu_DASH_L_LPAREN_e_RPAREN_"]}, "metabolites": {"leu__L_e": -1.0}, "id": "EX_leu__L_e", "gene_reaction_rule": ""}, {"name": "KDO(2)-lipid (A) exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_lipa_LPAREN_e_RPAREN_"]}, "metabolites": {"lipa_e": -1.0}, "id": "EX_lipa_e", "gene_reaction_rule": ""}, {"name": "Cold adapted KDO(2)-lipid (A) exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_lipa_cold_LPAREN_e_RPAREN_"]}, "metabolites": {"lipa_cold_e": -1.0}, "id": "EX_lipa_cold_e", "gene_reaction_rule": ""}, {"name": "Lipoate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_lipoate_LPAREN_e_RPAREN_"]}, "metabolites": {"lipoate_e": -1.0}, "id": 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"upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["23CUMPtex"]}, "metabolites": {"23cump_p": 1.0, "23cump_e": -1.0}, "id": "23CUMPtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Inner Membrane", "name": "2,3-diaminopropionate transport in via proton symport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["23DAPPAt2pp"]}, "metabolites": {"23dappa_c": 1.0, "h_c": 1.0, "h_p": -1.0, "23dappa_p": -1.0}, "id": "23DAPPAt2pp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "2,3-diaminopropionate transport via diffusion", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["23DAPPAtex"]}, "metabolites": {"23dappa_e": -1.0, "23dappa_p": 1.0}, "id": "23DAPPAtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "2',3'-cyclic-nucleotide phosphodiesterase (UMP) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["23PDE2pp"]}, "metabolites": {"h2o_p": -1.0, "23cump_p": -1.0, "3ump_p": 1.0, "h_p": 1.0}, "id": "23PDE2pp", "gene_reaction_rule": "ECs5191"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "2',3'-cyclic-nucleotide phosphodiesterase (CMP) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["23PDE4pp"]}, "metabolites": {"h2o_p": -1.0, "3cmp_p": 1.0, "23ccmp_p": -1.0, "h_p": 1.0}, "id": "23PDE4pp", "gene_reaction_rule": "ECs5191"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "2',3'-cyclic-nucleotide phosphodiesterase (AMP) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["23PDE7pp"]}, "metabolites": {"3amp_p": 1.0, "h2o_p": -1.0, "h_p": 1.0, "23camp_p": -1.0}, "id": "23PDE7pp", "gene_reaction_rule": "ECs5191"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "2',3'-cyclic-nucleotide phosphodiesterase (GMP) 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"gene_reaction_rule": "ECs3692"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphatidate (n-C16:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPA161tipp"]}, "metabolites": {"2hdec9eg3p_c": 1.0, "2hdec9eg3p_p": -1.0}, "id": "2AGPA161tipp", "gene_reaction_rule": "ECs3692"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphatidate (n-C18:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPA180tipp"]}, "metabolites": {"2odecg3p_p": -1.0, "2odecg3p_c": 1.0}, "id": "2AGPA180tipp", "gene_reaction_rule": "ECs3692"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphatidate (n-C18:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPA181tipp"]}, "metabolites": {"2odec11eg3p_p": -1.0, "2odec11eg3p_c": 1.0}, "id": "2AGPA181tipp", "gene_reaction_rule": "ECs3692"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C12:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPE120tipp"]}, "metabolites": {"2agpe120_p": -1.0, "2agpe120_c": 1.0}, "id": "2AGPE120tipp", "gene_reaction_rule": "ECs3692"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C14:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPE140tipp"]}, "metabolites": {"2agpe140_c": 1.0, "2agpe140_p": -1.0}, "id": "2AGPE140tipp", "gene_reaction_rule": "ECs3692"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C14:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPE141tipp"]}, "metabolites": {"2agpe141_c": 1.0, "2agpe141_p": -1.0}, "id": "2AGPE141tipp", "gene_reaction_rule": "ECs3692"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C16:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPE160tipp"]}, "metabolites": {"2agpe160_p": -1.0, "2agpe160_c": 1.0}, "id": "2AGPE160tipp", "gene_reaction_rule": "ECs3692"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C16:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPE161tipp"]}, "metabolites": {"2agpe161_p": -1.0, "2agpe161_c": 1.0}, "id": "2AGPE161tipp", "gene_reaction_rule": "ECs3692"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoethanolamine 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{"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C14:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPG141tipp"]}, "metabolites": {"2agpg141_p": -1.0, "2agpg141_c": 1.0}, "id": "2AGPG141tipp", "gene_reaction_rule": "ECs3692"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPG160tipp"]}, "metabolites": {"2agpg160_c": 1.0, "2agpg160_p": -1.0}, "id": "2AGPG160tipp", "gene_reaction_rule": "ECs3692"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPG161tipp"]}, "metabolites": {"2agpg161_c": 1.0, 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"2-acyl-glycerophospho-glycerol acyltransferase (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPGAT160"]}, "metabolites": {"2agpg160_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "pg160_c": 1.0, "hdca_c": -1.0}, "id": "2AGPGAT160", "gene_reaction_rule": "ECs3693"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-glycerol acyltransferase (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPGAT161"]}, "metabolites": {"atp_c": -1.0, "2agpg161_c": -1.0, "ppi_c": 1.0, "hdcea_c": -1.0, "pg161_c": 1.0, "amp_c": 1.0}, "id": "2AGPGAT161", "gene_reaction_rule": "ECs3693"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-glycerol acyltransferase (n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPGAT180"]}, "metabolites": {"pg180_c": 1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "ocdca_c": -1.0, 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(LalaDgluMdap) transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["3PEPTabcpp"]}, "metabolites": {"h2o_c": -1.0, "LalaDgluMdap_p": -1.0, "atp_c": -1.0, "adp_c": 1.0, "h_c": 1.0, "LalaDgluMdap_c": 1.0, "pi_c": 1.0}, "id": "3PEPTabcpp", "gene_reaction_rule": "ECs1911 and ECs1744 and ECs1745 and ECs1746 and ECs1747"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "LalaDgluMdap (tripeptide) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["3PEPTtex"]}, "metabolites": {"LalaDgluMdap_e": -1.0, "LalaDgluMdap_p": 1.0}, "id": "3PEPTtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "3UMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["3UMPtex"]}, "metabolites": {"3ump_e": -1.0, "3ump_p": 1.0}, "id": "3UMPtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "4-hydroxyphenylacetaldehyde transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["4HOXPACDtex"]}, "metabolites": {"4hoxpacd_p": 1.0, "4hoxpacd_e": -1.0}, "id": "4HOXPACDtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "4-Hydroxy-L-threonine synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["4HTHRS"]}, "metabolites": {"phthr_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0, "4hthr_c": 1.0}, "id": "4HTHRS", "gene_reaction_rule": "ECs0004"}, {"subsystem": "Murein Recycling", "name": "Tetrapeptide L,D-carboxypeptidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["4PCP"]}, "metabolites": {"h2o_c": -1.0, "ala__D_c": 1.0, "LalaDgluMdapDala_c": -1.0, "LalaDgluMdap_c": 1.0}, "id": "4PCP", "gene_reaction_rule": "ECs1688"}, {"subsystem": "Murein Recycling", "name": "Tetrapeptide L,D-carboxypeptidase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["4PCPpp"]}, "metabolites": {"LalaDgluMdapDala_p": -1.0, "h2o_p": -1.0, "LalaDgluMdap_p": 1.0, "ala__D_p": 1.0}, "id": "4PCPpp", "gene_reaction_rule": ""}, {"subsystem": "Murein Recycling", "name": "Tetrapeptide (LalaDgluMdapDala) transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["4PEPTabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "LalaDgluMdapDala_c": 1.0, "LalaDgluMdapDala_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "4PEPTabcpp", "gene_reaction_rule": "ECs1743 and ECs1744 and ECs1745 and ECs1746 and ECs1747"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "LalaDgluMdapDala (pentapeptide) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["4PEPTtex"]}, "metabolites": {"LalaDgluMdapDala_p": 1.0, "LalaDgluMdapDala_e": -1.0}, "id": "4PEPTtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "5-Dehydro-D-gluconate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["5DGLCNtex"]}, "metabolites": {"5dglcn_p": 1.0, "5dglcn_e": -1.0}, "id": "5DGLCNtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ECs3104 or ompN"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "5'-deoxyadenosine nuclosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["5DOAN"]}, "metabolites": {"h2o_c": -1.0, "ade_c": 1.0, "dad_5_c": -1.0, "5drib_c": 1.0}, "id": "5DOAN", "gene_reaction_rule": "ECs0163"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "5-Methylthio-D-ribose transport via proton diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["5MTRtex"]}, "metabolites": {"5mtr_e": -1.0, "5mtr_p": 1.0}, "id": "5MTRtex", "gene_reaction_rule": "ompN or ECs1012 or ECs3104 or ECs0268"}, {"subsystem": "Transport, Inner Membrane", "name": "5-Methylthio-D-ribose transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["5MTRtpp"]}, "metabolites": {"5mtr_c": -1.0, "h_c": -1.0, "h_p": 1.0, "5mtr_p": 1.0}, "id": "5MTRtpp", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Arabinose-5-phosphate isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["A5PISO"]}, "metabolites": {"ara5p_c": 1.0, "ru5p__D_c": -1.0}, "id": "A5PISO", "gene_reaction_rule": "ECs4076 or ECs3564"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase (n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS1"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "ACP_c": -1.0, "amp_c": 1.0, "myrsACP_c": 1.0, "ttdca_c": -1.0}, "id": "AACPS1", "gene_reaction_rule": "ECs3693 and ECs1472"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase  (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS2"]}, "metabolites": {"atp_c": -1.0, "tdeACP_c": 1.0, "ppi_c": 1.0, "ACP_c": -1.0, "amp_c": 1.0, "ttdcea_c": -1.0}, "id": "AACPS2", "gene_reaction_rule": "ECs3693 and ECs1472"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase  (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS3"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "ACP_c": -1.0, "amp_c": 1.0, "palmACP_c": 1.0, "hdca_c": -1.0}, "id": "AACPS3", "gene_reaction_rule": "ECs3693 and ECs1472"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase  (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS4"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "ACP_c": -1.0, "hdcea_c": -1.0, "amp_c": 1.0, "hdeACP_c": 1.0}, "id": "AACPS4", "gene_reaction_rule": "ECs3693 and ECs1472"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase  (n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS5"]}, "metabolites": {"ocdcea_c": -1.0, "atp_c": -1.0, "octeACP_c": 1.0, "ACP_c": -1.0, "amp_c": 1.0, "ppi_c": 1.0}, "id": "AACPS5", "gene_reaction_rule": "ECs3693 and ECs1472"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase  (n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS6"]}, "metabolites": {"atp_c": -1.0, 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"lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS9"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "ACP_c": -1.0, "octa_c": -1.0, "ocACP_c": 1.0, "amp_c": 1.0}, "id": "AACPS9", "gene_reaction_rule": "ECs3693 and ECs1472"}, {"subsystem": "Methylglyoxal Metabolism", "name": "Aminoacetone:oxygen oxidoreductase(deaminating)(flavin-containing)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACTOOR"]}, "metabolites": {"o2_c": -1.0, "h2o_c": -1.0, "aact_c": -1.0, "h2o2_c": 1.0, "mthgxl_c": 1.0, "nh4_c": 1.0}, "id": "AACTOOR", "gene_reaction_rule": ""}, {"subsystem": "Cell Envelope Biosynthesis", "name": "DTDP-N-4-acetamido-4,6-dideoxy-D-galactose transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AADDGT"]}, "metabolites": {"unagamuf_c": 1.0, "unagamu_c": -1.0, "dtdp_c": 1.0, "h_c": 1.0, "dtdp4aaddg_c": -1.0}, "id": "AADDGT", "gene_reaction_rule": "ECs4726"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Alpha-amylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AAMYL"]}, "metabolites": {"14glucan_c": -1.0, "malthx_c": 1.0}, "id": "AAMYL", "gene_reaction_rule": "ECs2666"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Alpha-amylase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AAMYLpp"]}, "metabolites": {"14glucan_p": -1.0, "malthx_p": 1.0}, "id": "AAMYLpp", "gene_reaction_rule": "ECs4454"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Arbutin 6-phosphate glucohydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AB6PGH"]}, "metabolites": {"h2o_c": -1.0, "g6p_c": 1.0, "hqn_c": 1.0, "arbt6p_c": -1.0}, "id": "AB6PGH", "gene_reaction_rule": "ECs3773"}, {"subsystem": "Arginine and Proline Metabolism", "name": "4-aminobutyrate transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ABTA"]}, "metabolites": {"akg_c": -1.0, "glu__L_c": 1.0, "sucsal_c": 1.0, "4abut_c": -1.0}, "id": "ABTA", "gene_reaction_rule": "ECs3523 or ECs1879"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Aminobutyraldehyde dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ABUTD"]}, "metabolites": {"h2o_c": -1.0, "4abutn_c": -1.0, "4abut_c": 1.0, "h_c": 2.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "ABUTD", "gene_reaction_rule": "ECs2048"}, {"subsystem": "Transport, Inner Membrane", "name": "4-aminobutyrate transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ABUTt2pp"]}, "metabolites": {"4abut_p": -1.0, "h_c": 1.0, "h_p": -1.0, "4abut_c": 1.0}, "id": "ABUTt2pp", "gene_reaction_rule": "ECs3524"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "4-aminobutyrate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ABUTtex"]}, 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"hxcoa_c": -1.0, "3oocoa_c": 1.0, "accoa_c": -1.0}, "id": "ACACT3r", "gene_reaction_rule": "ECs3225 or ECs4773"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA C-acyltransferase (octanoyl-CoA) (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT4r"]}, "metabolites": {"coa_c": 1.0, "3odcoa_c": 1.0, "occoa_c": -1.0, "accoa_c": -1.0}, "id": "ACACT4r", "gene_reaction_rule": "ECs3225 or ECs4773"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA C-acyltransferase (decanoyl-CoA) (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT5r"]}, "metabolites": {"3oddcoa_c": 1.0, "coa_c": 1.0, "dcacoa_c": -1.0, "accoa_c": -1.0}, "id": "ACACT5r", "gene_reaction_rule": "ECs3225 or ECs4773"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA C-acyltransferase (dodecanoyl-CoA) (r)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACACT6r"]}, 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-1000.0, "notes": {"original_bigg_ids": ["ACACtex"]}, "metabolites": {"acac_p": 1.0, "acac_e": -1.0}, "id": "ACACtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Pyruvate Metabolism", "name": "Acetaldehyde dehydrogenase (acetylating)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACALD"]}, "metabolites": {"accoa_c": 1.0, "acald_c": -1.0, "coa_c": -1.0, "h_c": 1.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "ACALD", "gene_reaction_rule": "ECs0406 or ECs1741"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Acetaldehyde transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACALDtex"]}, "metabolites": {"acald_p": 1.0, "acald_e": -1.0}, "id": "ACALDtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Inner Membrane", "name": "Acetaldehyde reversible transport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACALDtpp"]}, "metabolites": {"acald_c": 1.0, "acald_p": -1.0}, "id": "ACALDtpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Acetyl-CoA:anthranilate acetyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACANTHAT"]}, "metabolites": {"anth_c": -1.0, "coa_c": 1.0, "accoa_c": -1.0, "acanth_c": 1.0}, "id": "ACANTHAT", "gene_reaction_rule": "ECs2066"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Adenosyl cobinamide phosphate guanyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACBIPGT"]}, "metabolites": {"adocbip_c": -1.0, "ppi_c": 1.0, "gtp_c": -1.0, "h_c": -1.0, "agdpcbi_c": 1.0}, "id": "ACBIPGT", "gene_reaction_rule": "ECs2788"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acetyl-CoA carboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, 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1-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACGAL1Ptex"]}, "metabolites": {"acgal1p_p": 1.0, "acgal1p_e": -1.0}, "id": "ACGAL1Ptex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "N-acetyl-D-galactosamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACGALtex"]}, "metabolites": {"acgal_p": 1.0, "acgal_e": -1.0}, "id": "ACGALtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Alternate Carbon Metabolism", "name": "N-acetyl-D-glucosamine 1-phosphatase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGAM1PPpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "acgam_p": 1.0, "acgam1p_p": -1.0}, "id": "ACGAM1PPpp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "N-acetyl-D-glucosamine 1-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACGAM1Ptex"]}, "metabolites": {"acgam1p_e": -1.0, "acgam1p_p": 1.0}, "id": "ACGAM1Ptex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Murein Recycling", "name": "N-acetylglucosamine kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGAMK"]}, "metabolites": {"acgam_c": -1.0, "acgam6p_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "ACGAMK", "gene_reaction_rule": "ECs1497"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylglucosamine:undecaprenylphosphate N-acetylglucosamine -1-phosphate transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGAMT"]}, "metabolites": {"uacgam_c": -1.0, "ump_c": 1.0, "unaga_c": 1.0, "udcpp_c": -1.0}, "id": "ACGAMT", "gene_reaction_rule": "ECs4717"}, {"subsystem": "Transport, Inner Membrane", "name": "N-Acetyl-D-glucosamine transport via PEP:Pyr PTS  (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGAptspp"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "acgam_p": -1.0, "acgam6p_c": 1.0}, "id": "ACGAptspp", "gene_reaction_rule": "(ECs3289 and ECs1479 and ECs3287 and ECs3288) or (ECs0709 and ECs3287 and ECs3288)"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "N-Acetyl-D-glucosamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACGAtex"]}, "metabolites": {"acgam_p": 1.0, "acgam_e": -1.0}, "id": "ACGAtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Acetylglutamate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGK"]}, "metabolites": {"acg5p_c": 1.0, "acglu_c": -1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "ACGK", "gene_reaction_rule": "ECs4888"}, {"subsystem": "Arginine and Proline Metabolism", "name": "N-acetylglutamate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGS"]}, "metabolites": {"glu__L_c": -1.0, "acglu_c": 1.0, "coa_c": 1.0, "h_c": 1.0, "accoa_c": -1.0}, "id": "ACGS", "gene_reaction_rule": "ECs3675"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "2-aceto-2-hydroxybutanoate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACHBS"]}, "metabolites": {"2ahbut_c": 1.0, "pyr_c": -1.0, "2obut_c": -1.0, "co2_c": 1.0, "h_c": -1.0}, "id": "ACHBS", "gene_reaction_rule": "(ECs4611 and ECs4612) or (ECs0081 and ECs0082)"}, {"subsystem": "Pyruvate Metabolism", "name": "Acetate kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACKr"]}, "metabolites": {"ac_c": -1.0, "actp_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "ACKr", "gene_reaction_rule": "ECs3995 or ECs3180 or ECs2559"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Acetolactate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACLS"]}, "metabolites": {"pyr_c": -2.0, "co2_c": 1.0, "h_c": -1.0, "alac__S_c": 1.0}, "id": "ACLS", "gene_reaction_rule": "(ECs4611 and ECs4612) or (ECs0081 and ECs0082)"}, {"subsystem": "Alternate Carbon Metabolism", "name": "N-acetylmuramate 6-phosphate hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACM6PH"]}, "metabolites": {"acgam6p_c": 1.0, "h2o_c": -1.0, "lac__D_c": 1.0, "acmum6p_c": -1.0}, "id": "ACM6PH", "gene_reaction_rule": "ECs3299"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetyl-D-mannosaminuronic acid transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACMAMUT"]}, "metabolites": {"udp_c": 1.0, "unagamu_c": 1.0, "h_c": 1.0, "uacmamu_c": -1.0, "unaga_c": -1.0}, "id": "ACMAMUT", "gene_reaction_rule": "ECs4728"}, {"subsystem": "Transport, Inner Membrane", "name": "N-acetyl-D-mannosamine transport via PTS  (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACMANAptspp"]}, "metabolites": {"acmana_p": -1.0, "pep_c": -1.0, "pyr_c": 1.0, "acmanap_c": 1.0}, "id": "ACMANAptspp", "gene_reaction_rule": "ECs2527 and ECs2528 and ECs2529 and ECs3287 and ECs3288"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "N-acetyl-D-mannosamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACMANAtex"]}, "metabolites": {"acmana_p": 1.0, "acmana_e": -1.0}, "id": "ACMANAtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Inner Membrane", "name": "N-acetylmuramate transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACMUMptspp"]}, "metabolites": {"pep_c": -1.0, "acmum6p_c": 1.0, "pyr_c": 1.0, "acmum_p": -1.0}, "id": "ACMUMptspp", "gene_reaction_rule": "ECs3289 and ECs3300 and ECs3287 and ECs3288"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "N-acetylmuramate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACMUMtex"]}, "metabolites": {"acmum_e": -1.0, "acmum_p": 1.0}, "id": "ACMUMtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Inner Membrane", "name": "N-acetylneuraminate proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACNAMt2pp"]}, "metabolites": {"h_p": -1.0, "acnam_c": 1.0, "acnam_p": -1.0, "h_c": 1.0}, "id": "ACNAMt2pp", "gene_reaction_rule": "ECs4097"}, {"subsystem": "Transport, Outer Membrane", "name": "N-acetylneuraminate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACNAMtex"]}, "metabolites": {"acnam_e": -1.0, "acnam_p": 1.0}, "id": "ACNAMtex", "gene_reaction_rule": "ECs5270 or ECs1012 or ECs3104"}, {"subsystem": "Alternate Carbon Metabolism", "name": "N-Acetylneuraminate lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACNML"]}, "metabolites": {"pyr_c": 1.0, "acmana_c": 1.0, "acnam_c": -1.0}, "id": "ACNML", "gene_reaction_rule": "ECs4098"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (butanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOAD1f"]}, "metabolites": {"btcoa_c": -1.0, "b2coa_c": 1.0, "fadh2_c": 1.0, "fad_c": -1.0}, "id": "ACOAD1f", "gene_reaction_rule": "ECs0248"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (hexanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOAD2f"]}, "metabolites": {"fadh2_c": 1.0, "hxcoa_c": -1.0, "fad_c": -1.0, "hx2coa_c": 1.0}, "id": "ACOAD2f", "gene_reaction_rule": "ECs0248"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (octanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOAD3f"]}, "metabolites": {"oc2coa_c": 1.0, "fadh2_c": 1.0, "occoa_c": -1.0, "fad_c": -1.0}, "id": "ACOAD3f", "gene_reaction_rule": "ECs0248"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (decanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOAD4f"]}, "metabolites": {"fadh2_c": 1.0, "dc2coa_c": 1.0, "dcacoa_c": -1.0, "fad_c": -1.0}, "id": "ACOAD4f", "gene_reaction_rule": "ECs0248"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (dodecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOAD5f"]}, "metabolites": {"ddcacoa_c": -1.0, "fadh2_c": 1.0, "fad_c": -1.0, "dd2coa_c": 1.0}, "id": "ACOAD5f", "gene_reaction_rule": "ECs0248"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (tetradecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOAD6f"]}, "metabolites": {"fadh2_c": 1.0, "fad_c": -1.0, "tdcoa_c": -1.0, "td2coa_c": 1.0}, "id": "ACOAD6f", "gene_reaction_rule": "ECs0248"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (hexadecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOAD7f"]}, "metabolites": {"pmtcoa_c": -1.0, "fadh2_c": 1.0, "fad_c": -1.0, "hdd2coa_c": 1.0}, "id": "ACOAD7f", "gene_reaction_rule": "ECs0248"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Acyl-CoA dehydrogenase (octadecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACOAD8f"]}, "metabolites": {"stcoa_c": -1.0, 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"Acyl-(acyl carrier protein):phosphate acyltransferase (C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACPPAT181"]}, "metabolites": {"octeACP_c": -1.0, "ACP_c": 1.0, "h_c": -1.0, "ocdceap_c": 1.0, "pi_c": -1.0}, "id": "ACPPAT181", "gene_reaction_rule": "ECs1472 and ECs1468"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Acyl-carrier protein synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACPS1"]}, "metabolites": {"coa_c": -1.0, "ACP_c": 1.0, "pap_c": 1.0, "h_c": 1.0, "apoACP_c": -1.0}, "id": "ACPS1", "gene_reaction_rule": "ECs4342 or ECs3429"}, {"subsystem": "Pyruvate Metabolism", "name": "Acetyl-CoA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACS"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "coa_c": -1.0, "amp_c": 1.0, "accoa_c": 1.0, "ac_c": -1.0}, "id": "ACS", "gene_reaction_rule": "ECs5051"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "O-Acetyl-L-serine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACSERtex"]}, "metabolites": {"acser_p": 1.0, "acser_e": -1.0}, "id": "ACSERtex", "gene_reaction_rule": "ompN or ECs3104 or ECs0268 or ECs1012"}, {"subsystem": "Transport, Inner Membrane", "name": "O-Acetyl-L-serine export via facilitated transport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACSERtpp"]}, "metabolites": {"acser_p": 1.0, "acser_c": -1.0}, "id": "ACSERtpp", "gene_reaction_rule": "ECs3444 or ECs2140"}, {"subsystem": "Transport, Inner Membrane", "name": "Acetate reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACt2rpp"]}, "metabolites": {"ac_p": -1.0, "ac_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "ACt2rpp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Inner Membrane", "name": "Na+/Acetate symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACt4pp"]}, "metabolites": {"na1_p": -1.0, "ac_p": -1.0, "ac_c": 1.0, "na1_c": 1.0}, "id": "ACt4pp", "gene_reaction_rule": "ECs5049"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Acetate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACtex"]}, "metabolites": {"ac_p": 1.0, "ac_e": -1.0}, "id": "ACtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Adenosine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADA"]}, "metabolites": {"h2o_c": -1.0, "nh4_c": 1.0, "adn_c": -1.0, "h_c": -1.0, "ins_c": 1.0}, "id": "ADA", "gene_reaction_rule": "ECs2331"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "4-aminobenzoate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADCL"]}, "metabolites": {"pyr_c": 1.0, "4adcho_c": -1.0, "h_c": 1.0, "4abz_c": 1.0}, "id": "ADCL", "gene_reaction_rule": "ECs1474"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "4-amino-4-deoxychorismate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADCS"]}, "metabolites": {"glu__L_c": 1.0, "4adcho_c": 1.0, "chor_c": -1.0, "gln__L_c": -1.0}, "id": "ADCS", "gene_reaction_rule": "ECs4211 and ECs2521"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Adenine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADD"]}, "metabolites": {"h2o_c": -1.0, "ade_c": -1.0, "hxan_c": 1.0, "nh4_c": 1.0, "h_c": -1.0}, "id": "ADD", "gene_reaction_rule": "ECs4602"}, {"subsystem": "Transport, Inner Membrane", "name": "Adenine transport via proton symport (reversible) (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ADEt2rpp"]}, "metabolites": {"ade_p": -1.0, "ade_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "ADEt2rpp", "gene_reaction_rule": "ECs4530 or ECs4651"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Adenine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ADEtex"]}, "metabolites": {"ade_p": 1.0, "ade_e": -1.0}, "id": "ADEtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Adenylate kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ADK1"]}, "metabolites": {"amp_c": -1.0, "atp_c": -1.0, "adp_c": 2.0}, "id": "ADK1", "gene_reaction_rule": "ECs0527"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Adentylate kinase (GTP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ADK3"]}, "metabolites": {"gdp_c": 1.0, "gtp_c": -1.0, "amp_c": -1.0, "adp_c": 1.0}, "id": "ADK3", "gene_reaction_rule": "ECs0527"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Adentylate kinase (ITP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ADK4"]}, "metabolites": {"itp_c": -1.0, "idp_c": 1.0, "adp_c": 1.0, "amp_c": -1.0}, "id": "ADK4", "gene_reaction_rule": "ECs0527"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Adenosylmethionine decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADMDC"]}, "metabolites": {"amet_c": -1.0, "co2_c": 1.0, "h_c": -1.0, "ametam_c": 1.0}, "id": "ADMDC", "gene_reaction_rule": "ECs0124"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Adenylate cyclase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADNCYC"]}, "metabolites": {"ppi_c": 1.0, "camp_c": 1.0, "atp_c": -1.0}, "id": "ADNCYC", "gene_reaction_rule": "ECs4736"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Adenosine kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADNK1"]}, "metabolites": {"h_c": 1.0, "adn_c": -1.0, "amp_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "ADNK1", "gene_reaction_rule": "ECs0527"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Adenosine hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADNUC"]}, "metabolites": {"h2o_c": -1.0, "ade_c": 1.0, "adn_c": -1.0, "rib__D_c": 1.0}, "id": "ADNUC", "gene_reaction_rule": "ECs0033"}, {"subsystem": "Transport, Inner Membrane", "name": "Adenosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADNt2pp"]}, "metabolites": {"adn_c": 1.0, "h_c": 1.0, "h_p": -1.0, "adn_p": -1.0}, "id": "ADNt2pp", "gene_reaction_rule": "ECs3840 or ECs3272"}, {"subsystem": "Transport, Outer Membrane", "name": "Adenosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ADNtex"]}, "metabolites": {"adn_e": -1.0, "adn_p": 1.0}, "id": "ADNtex", "gene_reaction_rule": "ECs0464"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Adenosyl cobinamide kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADOCBIK"]}, "metabolites": {"adocbip_c": 1.0, "adocbi_c": -1.0, "atp_c": -1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "ADOCBIK", "gene_reaction_rule": "ECs2788"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Adenosylcobalamin 5'-phosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADOCBLS"]}, "metabolites": {"adocbl_c": 1.0, "gmp_c": 1.0, "h_c": 1.0, "rdmbzi_c": -1.0, "agdpcbi_c": -1.0}, "id": "ADOCBLS", "gene_reaction_rule": "ECs2787"}, {"subsystem": "Transport, Inner Membrane", "name": "Adenosylcobalamin transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADOCBLabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "adocbl_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "adocbl_p": -1.0, "pi_c": 1.0}, "id": "ADOCBLabcpp", "gene_reaction_rule": "ECs2418 and ECs2416 and ECs0162"}, {"subsystem": "Transport, Outer Membrane", "name": "Adenosylcobalimin transport via ton system (extermal)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADOCBLtonex"]}, "metabolites": {"adocbl_p": 1.0, "h_c": 1.0, "h_p": -1.0, "adocbl_e": -1.0}, "id": "ADOCBLtonex", "gene_reaction_rule": "ECs4897 and (ECs1752 and ECs3889 and ECs3890)"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "ADPribose diphosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADPRDP"]}, "metabolites": {"h2o_c": -1.0, "r5p_c": 1.0, "amp_c": 1.0, "adprib_c": -1.0, "h_c": 2.0}, "id": "ADPRDP", "gene_reaction_rule": "ECs4239 or ECs3922"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Adenine phosphoribosyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADPT"]}, "metabolites": {"ppi_c": 1.0, "ade_c": -1.0, "amp_c": 1.0, "prpp_c": -1.0}, "id": "ADPT", "gene_reaction_rule": "ECs0522"}, {"subsystem": "Cysteine Metabolism", "name": "Adenylyl-sulfate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADSK"]}, "metabolites": {"atp_c": -1.0, "paps_c": 1.0, "aps_c": -1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "ADSK", "gene_reaction_rule": "ECs3604"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Adenylsuccinate lyase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ADSL1r"]}, "metabolites": {"fum_c": 1.0, "amp_c": 1.0, "dcamp_c": -1.0}, "id": "ADSL1r", "gene_reaction_rule": "ECs1603"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Adenylosuccinate lyase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ADSL2r"]}, "metabolites": {"aicar_c": 1.0, "fum_c": 1.0, "25aics_c": -1.0}, "id": "ADSL2r", "gene_reaction_rule": "ECs1603"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Adenylosuccinate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADSS"]}, "metabolites": {"gdp_c": 1.0, "asp__L_c": -1.0, "gtp_c": -1.0, "h_c": 2.0, "pi_c": 1.0, "imp_c": -1.0, "dcamp_c": 1.0}, "id": "ADSS", "gene_reaction_rule": "ECs5153"}, {"subsystem": "Alternate Carbon Metabolism", "name": "N-acetylglucosamine-6-phosphate deacetylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGDC"]}, "metabolites": {"h2o_c": -1.0, "ac_c": 1.0, "acgam6p_c": -1.0, "gam6p_c": 1.0}, "id": "AGDC", "gene_reaction_rule": "ECs0707"}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tripeptide amidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM3PA"]}, "metabolites": 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1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM3Pt2pp"]}, "metabolites": {"h_p": -1.0, "h_c": 1.0, "anhgm3p_p": -1.0, "anhgm3p_c": 1.0}, "id": "AGM3Pt2pp", "gene_reaction_rule": "ECs0487"}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide amidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM4PA"]}, "metabolites": {"h2o_c": -1.0, "anhgm4p_c": -1.0, "LalaDgluMdapDala_c": 1.0, "anhgm_c": 1.0}, "id": "AGM4PA", "gene_reaction_rule": "ECs0114"}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide amidase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM4PApp"]}, "metabolites": {"h2o_p": -1.0, "anhgm4p_p": -1.0, "anhgm_p": 1.0, "LalaDgluMdapDala_p": 1.0}, "id": "AGM4PApp", "gene_reaction_rule": "ECs3306 or ECs3674 or ECs5145"}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide L,D-carboxypeptidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM4PCP"]}, "metabolites": {"ala__D_c": 1.0, "h2o_c": -1.0, "anhgm4p_c": -1.0, "anhgm3p_c": 1.0}, "id": "AGM4PCP", "gene_reaction_rule": "ECs1688"}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide L,D-carboxypeptidase (periplasmic)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM4PCPpp"]}, "metabolites": {"h2o_p": -1.0, "ala__D_p": 1.0, "anhgm3p_p": 1.0, "anhgm4p_p": -1.0}, "id": "AGM4PCPpp", "gene_reaction_rule": ""}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide beta -1,4-N-acetylglucosaminidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM4PH"]}, "metabolites": {"acgam_c": 1.0, "h2o_c": -1.0, "anhgm4p_c": -1.0, "anhm4p_c": 1.0}, "id": "AGM4PH", "gene_reaction_rule": "ECs1485"}, {"subsystem": "Murein Recycling", "name": "GlcNAc-anhMurNAc tetrapeptide transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGM4Pt2pp"]}, "metabolites": {"anhgm4p_c": 1.0, "h_c": 1.0, "h_p": -1.0, "anhgm4p_p": -1.0}, "id": "AGM4Pt2pp", "gene_reaction_rule": "ECs0487"}, {"subsystem": "Murein Recycling", "name": "N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl beta -1,4-N-acetylglucosaminidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGMH"]}, "metabolites": {"acgam_c": 1.0, "anhm_c": 1.0, "h2o_c": -1.0, "anhgm_c": -1.0}, "id": "AGMH", "gene_reaction_rule": "ECs1485"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "ADP-D-glycero-D-manno-heptose epimerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGMHE"]}, "metabolites": {"adphep_LD_c": 1.0, "adphep_DD_c": -1.0}, "id": "AGMHE", 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"Glycerophospholipid Metabolism", "name": "1-tetradecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT120"]}, "metabolites": {"1ddecg3p_c": -1.0, "ACP_c": 1.0, "pa120_c": 1.0, "ddcaACP_c": -1.0}, "id": "AGPAT120", "gene_reaction_rule": "ECs3902"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-tetradecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT140"]}, "metabolites": {"1tdecg3p_c": -1.0, "pa140_c": 1.0, "ACP_c": 1.0, "myrsACP_c": -1.0}, "id": "AGPAT140", "gene_reaction_rule": "ECs3902"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-tetradec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT141"]}, "metabolites": {"tdeACP_c": -1.0, "pa141_c": 1.0, "ACP_c": 1.0, "1tdec7eg3p_c": -1.0}, "id": "AGPAT141", "gene_reaction_rule": "ECs3902"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-hexadecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT160"]}, "metabolites": {"pa160_c": 1.0, "ACP_c": 1.0, "1hdecg3p_c": -1.0, "palmACP_c": -1.0}, "id": "AGPAT160", "gene_reaction_rule": "ECs3902"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-hexadec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT161"]}, "metabolites": {"pa161_c": 1.0, "1hdec9eg3p_c": -1.0, "ACP_c": 1.0, "hdeACP_c": -1.0}, "id": "AGPAT161", "gene_reaction_rule": "ECs3902"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-octadecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT180"]}, "metabolites": {"ocdcaACP_c": -1.0, "ACP_c": 1.0, "1odecg3p_c": -1.0, "pa180_c": 1.0}, "id": "AGPAT180", "gene_reaction_rule": "ECs3902"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-octadec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT181"]}, "metabolites": {"1odec11eg3p_c": -1.0, "octeACP_c": -1.0, "ACP_c": 1.0, "pa181_c": 1.0}, "id": "AGPAT181", "gene_reaction_rule": "ECs3902"}, {"subsystem": "Arginine and Proline Metabolism", "name": "N-acetyl-g-glutamyl-phosphate reductase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AGPR"]}, "metabolites": {"nadp_c": -1.0, "nadph_c": 1.0, "acg5p_c": 1.0, "acg5sa_c": -1.0, "h_c": 1.0, "pi_c": -1.0}, "id": "AGPR", "gene_reaction_rule": "ECs4887"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Silver transport out via proton antiport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGt3"]}, "metabolites": {"ag_e": 1.0, "h_e": -1.0, "h_c": 1.0, "ag_c": -1.0}, "id": "AGt3", "gene_reaction_rule": "ECs0610 and ECs0611 and ECs0612 and ECs0613"}, {"subsystem": "Methionine Metabolism", "name": "S-adenosylhomocysteine nucleosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AHCYSNS"]}, "metabolites": {"rhcys_c": 1.0, "h2o_c": -1.0, "ahcys_c": -1.0, "ade_c": 1.0}, "id": "AHCYSNS", "gene_reaction_rule": "ECs0163"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylaminoimidazolecarboxamide formyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AICART"]}, "metabolites": {"aicar_c": -1.0, "fprica_c": 1.0, "thf_c": 1.0, "10fthf_c": -1.0}, "id": "AICART", "gene_reaction_rule": "ECs4929"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylaminoimidazole carboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AIRC2"]}, "metabolites": {"5caiz_c": 1.0, "atp_c": -1.0, "hco3_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "air_c": -1.0, "pi_c": 1.0}, "id": "AIRC2", "gene_reaction_rule": "ECs0584"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylaminoimidazole carboxylase (mutase rxn)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AIRC3"]}, "metabolites": {"5caiz_c": 1.0, "5aizc_c": -1.0}, "id": "AIRC3", "gene_reaction_rule": "ECs0585"}, {"subsystem": "Citric Acid Cycle", "name": "2-Oxogluterate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AKGDH"]}, "metabolites": {"akg_c": -1.0, "co2_c": 1.0, "succoa_c": 1.0, "coa_c": -1.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "AKGDH", "gene_reaction_rule": "ECs0120 and ECs0751 and ECs0752"}, {"subsystem": "Transport, Inner Membrane", "name": "2-oxoglutarate reversible transport via symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AKGt2rpp"]}, "metabolites": {"akg_c": 1.0, "akg_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "AKGt2rpp", "gene_reaction_rule": "ECs3454"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Alpha-ketoglutarate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AKGtex"]}, "metabolites": {"akg_p": 1.0, "akg_e": -1.0}, "id": "AKGtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Murein Recycling", "name": "D-alanine-D-alanine dipeptidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAALAD"]}, "metabolites": {"h2o_c": -1.0, "ala__D_c": 2.0, "alaala_c": -1.0}, "id": "ALAALAD", "gene_reaction_rule": "ECs2092"}, {"subsystem": "Transport, Inner Membrane", "name": "D-alanyl-D-alanine (DalaDala) transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAALAabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "alaala_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "alaala_c": 1.0}, "id": "ALAALAabcpp", "gene_reaction_rule": "(ECs2091 and ECs2090 and ECs2089 and ECs2088 and ECs2087) or (ECs4424 and ECs4423 and ECs4422 and ECs4421 and ECs4420)"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "D-alanine-D-alanine ligase (reversible)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAALAr"]}, "metabolites": {"atp_c": -1.0, "ala__D_c": -2.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "alaala_c": 1.0}, "id": "ALAALAr", "gene_reaction_rule": "ECs0431 or ECs0096"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-alanyl-D-alanine (DalaDala) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAALAtex"]}, "metabolites": {"alaala_e": -1.0, "alaala_p": 1.0}, "id": "ALAALAtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Murein Recycling", "name": "L-alanyl-gamma-glutamate epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAGLUE"]}, "metabolites": {"LalaDglu_c": -1.0, "LalaLglu_c": 1.0}, "id": "ALAGLUE", "gene_reaction_rule": "ECs1904"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "Alanine racemase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAR"]}, "metabolites": {"ala__L_c": -1.0, "ala__D_c": 1.0}, "id": "ALAR", "gene_reaction_rule": "ECs1685 or ECs5035"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "D-alanine transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALATA_D2"]}, "metabolites": {"ala__D_c": -1.0, "pyr_c": 1.0, "pydx5p_c": -1.0, "pyam5p_c": 1.0}, "id": "ALATA_D2", "gene_reaction_rule": "ECs3417 or ECs0956"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "L-alanine transaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALATA_L"]}, "metabolites": {"akg_c": -1.0, "glu__L_c": 1.0, "ala__L_c": -1.0, "pyr_c": 1.0}, "id": "ALATA_L", "gene_reaction_rule": "ECs3174 or ECs3259"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Alanine transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALATA_L2"]}, "metabolites": {"pydx5p_c": -1.0, "pyam5p_c": 1.0, "ala__L_c": -1.0, "pyr_c": 1.0}, "id": "ALATA_L2", "gene_reaction_rule": "ECs0956 or ECs3417"}, {"subsystem": "tRNA Charging", "name": "Alanyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALATRS"]}, "metabolites": {"trnaala_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "ala__L_c": -1.0, "amp_c": 1.0, "alatrna_c": 1.0}, "id": "ALATRS", "gene_reaction_rule": "ECs3554"}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "ala__L_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "ala__L_p": -1.0}, "id": "ALAabcpp", "gene_reaction_rule": "ECs4301 and ECs4302 and ECs4304 and ECs4309 and ECs4303"}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAt2pp", "ALAt2rpp"]}, "metabolites": {"ala__L_c": 1.0, "h_c": 1.0, "h_p": -1.0, "ala__L_p": -1.0}, "id": "ALAt2pp_copy1", "gene_reaction_rule": "ECs5186"}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAt2pp", "ALAt2rpp"]}, "metabolites": {"ala__L_c": 1.0, "h_c": 1.0, "h_p": -1.0, "ala__L_p": -1.0}, "id": "ALAt2pp_copy2", "gene_reaction_rule": ""}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanine transport in via sodium symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAt4pp"]}, "metabolites": {"na1_p": -1.0, "na1_c": 1.0, "ala__L_c": 1.0, "ala__L_p": -1.0}, "id": "ALAt4pp", "gene_reaction_rule": "ECs0007"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-alanine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAtex"]}, "metabolites": {"ala__L_e": -1.0, "ala__L_p": 1.0}, "id": "ALAtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Alcohol dehydrogenase (glycerol)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALCD19"]}, "metabolites": {"h_c": -1.0, "nadh_c": -1.0, "glyald_c": -1.0, "nad_c": 1.0, "glyc_c": 1.0}, "id": "ALCD19", "gene_reaction_rule": "ECs0411"}, {"subsystem": "Pyruvate Metabolism", "name": "Alcohol dehydrogenase (ethanol)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALCD2x"]}, "metabolites": {"acald_c": 1.0, "nad_c": -1.0, "nadh_c": 1.0, "h_c": 1.0, "etoh_c": -1.0}, "id": "ALCD2x", "gene_reaction_rule": "ECs2082 or ECs1741 or ECs0411"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Aldehyde dehydrogenase (acetaldehyde, NAD)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALDD2x"]}, "metabolites": {"h2o_c": -1.0, "acald_c": -1.0, "h_c": 2.0, "nad_c": -1.0, "ac_c": 1.0, "nadh_c": 1.0}, "id": "ALDD2x", "gene_reaction_rule": "ECs1877"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Aldehyde dehydrogenase (acetaldehyde, NADP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALDD2y"]}, "metabolites": {"h2o_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "acald_c": -1.0, "h_c": 2.0, "ac_c": 1.0}, "id": "ALDD2y", "gene_reaction_rule": "ECs4464"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Aldehyde dehydrogenase (propanal, NADP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALDD3y"]}, "metabolites": {"h2o_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "ppa_c": 1.0, "ppal_c": -1.0, "h_c": 2.0}, "id": "ALDD3y", "gene_reaction_rule": "ECs4464"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Aldehyde dehydrogenase (butanal, NAD)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALDD4"]}, "metabolites": {"h2o_c": -1.0, "btal_c": -1.0, "but_c": 1.0, "h_c": 2.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "ALDD4", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Allantoate amidohydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALLTAMH"]}, "metabolites": {"alltt_c": -1.0, "urdglyc_c": 1.0, "h2o_c": -2.0, "h_c": -2.0, "co2_c": 1.0, "nh4_c": 2.0}, "id": "ALLTAMH", "gene_reaction_rule": "ECs0578"}, {"subsystem": "Nitrogen Metabolism", "name": "Allantoinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALLTN"]}, "metabolites": {"alltt_c": 1.0, "h2o_c": -1.0, "h_c": 1.0, "alltn_c": -1.0}, "id": "ALLTN", "gene_reaction_rule": "allB"}, {"subsystem": "Transport, Inner Membrane", "name": "Allantoin transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALLTNt2rpp"]}, "metabolites": {"h_p": -1.0, "h_c": 1.0, "alltn_c": 1.0, "alltn_p": -1.0}, "id": "ALLTNt2rpp", "gene_reaction_rule": "ECs0572"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Allantoin transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALLTNtex"]}, "metabolites": {"alltn_e": -1.0, "alltn_p": 1.0}, "id": "ALLTNtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Allose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALLtex"]}, "metabolites": {"all__D_p": 1.0, "all__D_e": -1.0}, "id": "ALLtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Unassigned", "name": "Apolipoprotein N-acyltransferase (phosphatidylethanolamine, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALPATE160pp"]}, "metabolites": {"alpp_p": -1.0, "lpp_p": 1.0, "2agpe160_p": 1.0, "pe160_p": -1.0}, "id": "ALPATE160pp", "gene_reaction_rule": "ECs0695 and ECs2384"}, {"subsystem": "Unassigned", "name": "Apolipoprotein N-acyltransferase (phosphatidylglycerol, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALPATG160pp"]}, "metabolites": {"pg160_p": -1.0, "alpp_p": -1.0, "2agpg160_p": 1.0, "lpp_p": 1.0}, "id": "ALPATG160pp", "gene_reaction_rule": "ECs0695 and ECs2384"}, {"subsystem": "Methylglyoxal Metabolism", "name": "Aldose reductase (methylglyoxal)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALR2"]}, "metabolites": {"nadph_c": -1.0, "nadp_c": 1.0, "acetol_c": 1.0, "h_c": -1.0, "mthgxl_c": -1.0}, "id": "ALR2", "gene_reaction_rule": "ECs3896 or ECs0203 or ECs2490 or ECs3885"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Aldose reductase (acetol)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALR4x"]}, "metabolites": {"nadh_c": -1.0, "acetol_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "12ppd__R_c": 1.0}, "id": "ALR4x", "gene_reaction_rule": "ECs4874"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Altronate hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALTRH"]}, "metabolites": {"h2o_c": 1.0, "2ddglcn_c": 1.0, "altrn_c": -1.0}, "id": "ALTRH", "gene_reaction_rule": "ECs3973"}, {"subsystem": "Murein Recycling", "name": "Anhydrous-N-Acetylmuramyl-tripeptide amidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AM3PA"]}, "metabolites": {"anhm_c": 1.0, "h2o_c": -1.0, "LalaDgluMdap_c": 1.0, "anhm3p_c": -1.0}, "id": "AM3PA", "gene_reaction_rule": "ECs0114"}, {"subsystem": "Murein Recycling", "name": "Anhydrous-N-Acetylmuramyl-tetrapeptide amidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AM4PA"]}, "metabolites": {"anhm_c": 1.0, "anhm4p_c": -1.0, "LalaDgluMdapDala_c": 1.0, "h2o_c": -1.0}, "id": "AM4PA", "gene_reaction_rule": "ECs0114"}, {"subsystem": "Murein Recycling", "name": "Anhydrous-N-Acetylmuramyl-tetrapeptide L,D-carboxypeptidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AM4PCP"]}, "metabolites": {"h2o_c": -1.0, "ala__D_c": 1.0, "anhm4p_c": -1.0, "anhm3p_c": 1.0}, "id": "AM4PCP", "gene_reaction_rule": "ECs1688"}, {"subsystem": "Alternate Carbon 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"8-amino-7-oxononanoate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AOXSr2"]}, "metabolites": {"ala__L_c": -1.0, "8aonn_c": 1.0, "co2_c": 1.0, "pimACP_c": -1.0, "ACP_c": 1.0}, "id": "AOXSr2", "gene_reaction_rule": "ECs0854"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Ap4A hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AP4AH"]}, "metabolites": {"ap4a_c": -1.0, "h2o_c": -1.0, "adp_c": 2.0, "h_c": 2.0}, "id": "AP4AH", "gene_reaction_rule": "ECs0054"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Ap4A synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AP4AS"]}, "metabolites": {"ap4a_c": 1.0, "ppi_c": 1.0, "atp_c": -2.0, "h_c": -1.0}, "id": "AP4AS", "gene_reaction_rule": "ECs3762"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Ap5A hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AP5AH"]}, "metabolites": 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(C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["APH160"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "hdca_c": 1.0, "h_c": 2.0, "hdcap_c": -1.0}, "id": "APH160", "gene_reaction_rule": "ECs1052"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Acylphosphatase (C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["APH161"]}, "metabolites": {"hdcea_c": 1.0, "hdceap_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0, "h_c": 2.0}, "id": "APH161", "gene_reaction_rule": "ECs1052"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Acylphosphatase (C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["APH180"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "ocdcap_c": -1.0, "h_c": 2.0, "ocdca_c": 1.0}, "id": "APH180", "gene_reaction_rule": "ECs1052"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Acylphosphatase (C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": 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"upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASCBptspp"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "ascb6p_c": 1.0, "ascb__L_p": -1.0}, "id": "ASCBptspp", "gene_reaction_rule": "ECs3287 and ECs3288 and ECs5171 and ECs5170 and ECs5169"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-ascorbate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ASCBtex"]}, "metabolites": {"ascb__L_p": 1.0, "ascb__L_e": -1.0}, "id": "ASCBtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "L-asparaginase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASNN"]}, "metabolites": {"asp__L_c": 1.0, "asn__L_c": -1.0, "h2o_c": -1.0, "nh4_c": 1.0}, "id": "ASNN", "gene_reaction_rule": "ECs2474 or iaaA"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "L-asparaginase", 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"Asparaginyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASNTRS"]}, "metabolites": {"trnaasn_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "asntrna_c": 1.0, "asn__L_c": -1.0}, "id": "ASNTRS", "gene_reaction_rule": "ECs1013"}, {"subsystem": "Transport, Inner Membrane", "name": "L-asparagine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ASNabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "asn__L_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "asn__L_p": -1.0, "pi_c": 1.0}, "id": "ASNabcpp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Inner Membrane", "name": "L-asparagine reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ASNt2rpp"]}, "metabolites": {"asn__L_p": -1.0, "asn__L_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "ASNt2rpp", "gene_reaction_rule": "ECs2057"}, {"subsystem": 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{"btn_p": 1.0, "btn_e": -1.0}, "id": "BTNtex", "gene_reaction_rule": "ECs3104 or ompN or ECs0268 or ECs1012"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Biotin synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["BTS5"]}, "metabolites": {"btn_c": 1.0, "dtbt_c": -1.0, "dad_5_c": 1.0, "2fe2s_c": -1.0, "h_c": 1.0, "met__L_c": 1.0, "2fe1s_c": 1.0, "amet_c": -1.0}, "id": "BTS5", "gene_reaction_rule": "ECs0853"}, {"subsystem": "Transport, Inner Membrane", "name": "Butanesulfonate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["BUTSO3abcpp"]}, "metabolites": {"h2o_c": -1.0, "butso3_p": -1.0, "atp_c": -1.0, "butso3_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "BUTSO3abcpp", "gene_reaction_rule": "(ECs1019 and ECs1016 and ECs1017) or (ECs0419 and ECs0420 and ECs0421)"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Butanesulfonate transport via 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ECs4779)"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Tungsten bispterin guanine dinucleotide synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["BWCOGDS2"]}, "metabolites": {"ppi_c": 1.0, "bwco1gdp_c": -1.0, "gtp_c": -1.0, "bwcogdp_c": 1.0, "h_c": -1.0}, "id": "BWCOGDS2", "gene_reaction_rule": "ECs4780 or (ECs4780 and ECs4779)"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Tungsten bispterin cofactor synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["BWCOS"]}, "metabolites": {"cu2_c": 1.0, "bwco_c": 1.0, "amp_c": 1.0, "wco_c": -1.0, "mptamp_c": -1.0}, "id": "BWCOS", "gene_reaction_rule": "ECs0905"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Calcium (Ca+2) transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CA2t3pp"]}, "metabolites": {"ca2_p": 1.0, "h_c": 1.0, "h_p": -1.0, "ca2_c": -1.0}, "id": "CA2t3pp", "gene_reaction_rule": "ECs1721"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Calcium (Ca+2) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CA2tex"]}, "metabolites": {"ca2_e": -1.0, "ca2_p": 1.0}, "id": "CA2tex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Inner Membrane", "name": "Lysine/Cadaverine antiporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CADVtpp"]}, "metabolites": {"lys__L_c": 1.0, "h_p": -1.0, "15dap_p": 1.0, "h_c": 1.0, "lys__L_p": -1.0, "15dap_c": -1.0}, "id": "CADVtpp", "gene_reaction_rule": "ECs5114"}, {"subsystem": "Unassigned", "name": "Catalase", "upper_bound": 0.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CAT"]}, "metabolites": {"o2_c": 1.0, "h2o_c": 2.0, "h2o2_c": -2.0}, "id": "CAT", "gene_reaction_rule": "ECs2438 or ECs4871"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Calcium / sodium antiporter (1:1)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CAt6pp"]}, "metabolites": {"na1_p": -1.0, "na1_c": 1.0, "ca2_c": -1.0, "ca2_p": 1.0}, "id": "CAt6pp", "gene_reaction_rule": "ECs4075"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Cobinamide adenyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CBIAT"]}, "metabolites": {"pppi_c": 1.0, "cbi_c": -1.0, "adocbi_c": 1.0, "h_c": -1.0, "atp_c": -1.0}, "id": "CBIAT", "gene_reaction_rule": "ECs1842"}, {"subsystem": "Transport, Outer Membrane", "name": "Cobinamide transport via ton system (extermal)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CBItonex"]}, "metabolites": {"cbi_p": 1.0, "cbi_e": -1.0, "h_p": -1.0, "h_c": 1.0}, "id": "CBItonex", "gene_reaction_rule": "ECs4897 and (ECs1752 and ECs3889 and ECs3890)"}, {"subsystem": "Transport, Inner Membrane", "name": "Cobinamide transport via ABC system (uptake, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CBIuabcpp"]}, "metabolites": {"cbi_p": -1.0, "h2o_c": -1.0, "atp_c": -1.0, "cbi_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "CBIuabcpp", "gene_reaction_rule": "ECs2418 and ECs2416 and ECs0162"}, {"subsystem": "Transport, Inner Membrane", "name": "Cob(1)alamin transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CBL1abcpp"]}, "metabolites": {"cbl1_p": -1.0, "h2o_c": -1.0, "atp_c": -1.0, "cbl1_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "CBL1abcpp", "gene_reaction_rule": "ECs2418 and ECs2416 and ECs0162"}, {"subsystem": "Transport, Outer Membrane", "name": "Cob(1)alamin transport via ton system (extermal)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CBL1tonex"]}, "metabolites": {"cbl1_p": 1.0, "cbl1_e": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "CBL1tonex", "gene_reaction_rule": "ECs4897 and (ECs1752 and ECs3889 and ECs3890)"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Cob(I)alamin adenosyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CBLAT"]}, "metabolites": {"pppi_c": 1.0, "cbl1_c": -1.0, "h_c": -1.0, "atp_c": -1.0, "adocbl_c": 1.0}, "id": "CBLAT", "gene_reaction_rule": "ECs1842"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Carbamate deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CBMD"]}, "metabolites": {"nh4_c": 1.0, "co2_c": 1.0, "h_c": -2.0, "cbm_c": -1.0}, "id": "CBMD", "gene_reaction_rule": "s0001"}, {"subsystem": "Unassigned", "name": "Carbamate kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CBMKr"]}, "metabolites": {"cbp_c": 1.0, "atp_c": -1.0, "h_c": 2.0, "adp_c": 1.0, "co2_c": -1.0, 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(+2) transport in via permease (no H+)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CD2tpp"]}, "metabolites": {"cd2_p": -1.0, "cd2_c": 1.0}, "id": "CD2tpp", "gene_reaction_rule": "ECs3928"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-Diacylglycerol pyrophostatase (n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDAPPA120"]}, "metabolites": {"cdpdddecg_c": -1.0, "h2o_c": -1.0, "cmp_c": 1.0, "h_c": 2.0, "pa120_c": 1.0}, "id": "CDAPPA120", "gene_reaction_rule": "ECs4843"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-Diacylglycerol pyrophostatase (n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDAPPA140"]}, "metabolites": {"cdpdtdecg_c": -1.0, "h2o_c": -1.0, "pa140_c": 1.0, "h_c": 2.0, "cmp_c": 1.0}, "id": "CDAPPA140", "gene_reaction_rule": "ECs4843"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-Diacylglycerol pyrophostatase (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDAPPA141"]}, "metabolites": {"pa141_c": 1.0, "h2o_c": -1.0, "cmp_c": 1.0, "h_c": 2.0, "cdpdtdec7eg_c": -1.0}, "id": "CDAPPA141", "gene_reaction_rule": "ECs4843"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-Diacylglycerol pyrophostatase (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDAPPA160"]}, "metabolites": {"pa160_c": 1.0, "h2o_c": -1.0, "cmp_c": 1.0, "h_c": 2.0, "cdpdhdecg_c": -1.0}, "id": "CDAPPA160", "gene_reaction_rule": "ECs4843"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-Diacylglycerol pyrophostatase (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDAPPA161"]}, "metabolites": {"pa161_c": 1.0, "h2o_c": -1.0, "cmp_c": 1.0, "h_c": 2.0, "cdpdhdec9eg_c": -1.0}, "id": "CDAPPA161", "gene_reaction_rule": "ECs4843"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-Diacylglycerol pyrophostatase (n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDAPPA180"]}, "metabolites": {"h_c": 2.0, "h2o_c": -1.0, "pa180_c": 1.0, "cdpdodecg_c": -1.0, "cmp_c": 1.0}, "id": "CDAPPA180", "gene_reaction_rule": "ECs4843"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-Diacylglycerol pyrophostatase (n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDAPPA181"]}, "metabolites": {"cdpdodec11eg_c": -1.0, "h2o_c": -1.0, "h_c": 2.0, "pa181_c": 1.0, "cmp_c": 1.0}, "id": "CDAPPA181", "gene_reaction_rule": "ECs4843"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "7-cyano-7-deazaguanine reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDGR"]}, "metabolites": {"preq1_c": 1.0, "preq0_c": -1.0, "nadp_c": 2.0, "nadph_c": -2.0, "h_c": -3.0}, "id": "CDGR", "gene_reaction_rule": "ECs3654"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "7-deaza-7-carboxyguanine synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDGS"]}, "metabolites": {"cdg_c": 1.0, "cph4_c": -1.0, "nh4_c": 1.0, "h_c": -1.0}, "id": "CDGS", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CDPMEK"]}, "metabolites": {"4c2me_c": -1.0, "2p4c2me_c": 1.0, "atp_c": -1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "CDPMEK", "gene_reaction_rule": "ECs1713"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cyclopropane fatty acid synthase (Phosphatidylethanolamine, n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CFAS160E"]}, "metabolites": {"cpe160_c": 1.0, "ahcys_c": 2.0, "pe161_c": -1.0, "h_c": 2.0, "amet_c": -2.0}, "id": "CFAS160E", "gene_reaction_rule": "ECs2370"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cyclopropane fatty acid synthase (Phosphatidylglycerol, n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CFAS160G"]}, "metabolites": {"amet_c": -2.0, "pg161_c": -1.0, "ahcys_c": 2.0, "h_c": 2.0, "cpg160_c": 1.0}, "id": "CFAS160G", "gene_reaction_rule": "ECs2370"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cyclopropane fatty acid synthase (Phosphatidylethanolamine, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CFAS180E"]}, "metabolites": {"amet_c": -2.0, "pe181_c": -1.0, "ahcys_c": 2.0, "h_c": 2.0, "cpe180_c": 1.0}, "id": "CFAS180E", "gene_reaction_rule": "ECs2370"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cyclopropane fatty acid synthase (Phosphatidylglycerol, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CFAS180G"]}, "metabolites": {"amet_c": -2.0, "cpg180_c": 1.0, "ahcys_c": 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1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH120pp"]}, "metabolites": {"h2o_p": -1.0, "pg120_p": 1.0, "pa120_p": 1.0, "h_p": 1.0, "clpn120_p": -1.0}, "id": "CLPNH120pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH140pp"]}, "metabolites": {"pa140_p": 1.0, "h2o_p": -1.0, "pg140_p": 1.0, "clpn140_p": -1.0, "h_p": 1.0}, "id": "CLPNH140pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH141pp"]}, "metabolites": {"h2o_p": -1.0, "pa141_p": 1.0, "pg141_p": 1.0, "h_p": 1.0, "clpn141_p": -1.0}, "id": "CLPNH141pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C16:0)", 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"CYTBO3_4pp", "gene_reaction_rule": "ECs0483 and ECs0484 and ECs0485 and ECs0486"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Cytidine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYTD"]}, "metabolites": {"cytd_c": -1.0, "uri_c": 1.0, "h2o_c": -1.0, "nh4_c": 1.0, "h_c": -1.0}, "id": "CYTD", "gene_reaction_rule": "ECs3035"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Cytidine hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYTDH"]}, "metabolites": {"cytd_c": -1.0, "h2o_c": -1.0, "csn_c": 1.0, "rib__D_c": 1.0}, "id": "CYTDH", "gene_reaction_rule": "ECs3054 or ECs0690 or ECs0033"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Cytidine kinase (GTP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYTDK2"]}, "metabolites": {"cytd_c": -1.0, "gdp_c": 1.0, "gtp_c": -1.0, "h_c": 1.0, "cmp_c": 1.0}, "id": "CYTDK2", "gene_reaction_rule": "ECs2873"}, {"subsystem": "Transport, Inner Membrane", "name": "Cytidine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYTDt2pp", "CYTDt2rpp"]}, "metabolites": {"cytd_c": 1.0, "cytd_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "CYTDt2pp_copy1", "gene_reaction_rule": "ECs3272 or ECs3840"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Cytidine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CYTDtex"]}, "metabolites": {"cytd_p": 1.0, "cytd_e": -1.0}, "id": "CYTDtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Cytidylate kinase (CMP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CYTK1"]}, "metabolites": {"cdp_c": 1.0, "atp_c": -1.0, "adp_c": 1.0, "cmp_c": -1.0}, "id": "CYTK1", "gene_reaction_rule": "ECs0993"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Cytidylate kinase (dCMP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CYTK2"]}, "metabolites": {"dcmp_c": -1.0, "atp_c": -1.0, "adp_c": 1.0, "dcdp_c": 1.0}, "id": "CYTK2", "gene_reaction_rule": "ECs0993"}, {"subsystem": "Transport, Inner Membrane", "name": "D-lactate transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["D_DASH_LACt2pp"]}, "metabolites": {"lac__D_c": 1.0, "h_c": 1.0, "h_p": -1.0, "lac__D_p": -1.0}, "id": "D_LACt2pp", "gene_reaction_rule": "ECs4481"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-lactate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["D_DASH_LACtex"]}, "metabolites": {"lac__D_e": -1.0, "lac__D_p": 1.0}, "id": "D_LACtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "D-Amino acid dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAAD"]}, "metabolites": {"h2o_c": -1.0, "pyr_c": 1.0, "fadh2_c": 1.0, "ala__D_c": -1.0, "nh4_c": 1.0, "fad_c": -1.0}, "id": "DAAD", "gene_reaction_rule": "ECs1684"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Deoxyadenosine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DADA"]}, "metabolites": {"din_c": 1.0, "dad_2_c": -1.0, "h2o_c": -1.0, "h_c": -1.0, "nh4_c": 1.0}, "id": "DADA", "gene_reaction_rule": "ECs2331"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Deoxyadenylate kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DADK", "DAMPK"]}, "metabolites": {"dadp_c": 1.0, "damp_c": -1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "DADK_copy1", "gene_reaction_rule": "ECs0527"}, {"subsystem": "Transport, Inner Membrane", "name": "Deoxyadenosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DADNt2pp"]}, "metabolites": {"dad_2_c": 1.0, "dad_2_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "DADNt2pp", "gene_reaction_rule": "ECs3840 or ECs3272"}, {"subsystem": "Transport, Outer Membrane", "name": "Deoxyadenosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DADNtex"]}, "metabolites": {"dad_2_p": 1.0, "dad_2_e": -1.0}, "id": "DADNtex", "gene_reaction_rule": "ECs0464"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Diacylglycerol kinase (n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAGK120"]}, "metabolites": {"adp_c": 1.0, "pa120_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "12dgr120_c": -1.0}, "id": "DAGK120", "gene_reaction_rule": "ECs5025"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Diacylglycerol kinase (n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAGK140"]}, "metabolites": {"h_c": 1.0, "pa140_c": 1.0, "atp_c": -1.0, "adp_c": 1.0, "12dgr140_c": -1.0}, "id": "DAGK140", "gene_reaction_rule": "ECs5025"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Diacylglycerol kinase (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAGK141"]}, "metabolites": {"pa141_c": 1.0, "12dgr141_c": -1.0, "atp_c": -1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "DAGK141", "gene_reaction_rule": "ECs5025"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Diacylglycerol kinase (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAGK160"]}, "metabolites": {"pa160_c": 1.0, "12dgr160_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "DAGK160", "gene_reaction_rule": "ECs5025"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Diacylglycerol kinase (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, 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{"original_bigg_ids": ["DAPAL"]}, "metabolites": {"h2o_c": -1.0, "pyr_c": 1.0, "nh4_c": 2.0, "23dappa_c": -1.0}, "id": "DAPAL", "gene_reaction_rule": "ECs3744"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Diaminopimelate decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAPDC"]}, "metabolites": {"co2_c": 1.0, "lys__L_c": 1.0, "h_c": -1.0, "26dap__M_c": -1.0}, "id": "DAPDC", "gene_reaction_rule": "ECs3695"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Diaminopimelate epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DAPE"]}, "metabolites": {"26dap_LL_c": -1.0, "26dap__M_c": 1.0}, "id": "DAPE", "gene_reaction_rule": "ECs4739"}, {"subsystem": "Transport, Inner Membrane", "name": "M-diaminopimelic acid ABC transport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAPabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "26dap__M_c": 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["DCTPD"]}, "metabolites": {"dutp_c": 1.0, "dctp_c": -1.0, "h_c": -1.0, "h2o_c": -1.0, "nh4_c": 1.0}, "id": "DCTPD", "gene_reaction_rule": "ECs2872"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Deoxycytidine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DCYTD"]}, "metabolites": {"dcyt_c": -1.0, "h2o_c": -1.0, "h_c": -1.0, "duri_c": 1.0, "nh4_c": 1.0}, "id": "DCYTD", "gene_reaction_rule": "ECs3035"}, {"subsystem": "Transport, Inner Membrane", "name": "Deoxycytidine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DCYTt2pp"]}, "metabolites": {"dcyt_c": 1.0, "dcyt_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "DCYTt2pp", "gene_reaction_rule": "ECs3272 or ECs3840"}, {"subsystem": "Transport, Outer Membrane", "name": "Deoxycytidine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DCYTtex"]}, "metabolites": {"dcyt_p": 1.0, "dcyt_e": -1.0}, "id": "DCYTtex", "gene_reaction_rule": "ECs0464"}, {"subsystem": "Transport, Outer Membrane", "name": "Fatty acid (dodecanoate) transport via facilitated irreversible diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DDCAtexi"]}, "metabolites": {"ddca_p": 1.0, "ddca_e": -1.0}, "id": "DDCAtexi", "gene_reaction_rule": "ECs3227"}, {"subsystem": "Transport, Inner Membrane", "name": "2-dehydro-3-deoxy-D-gluconate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DDGLCNt2rpp"]}, "metabolites": {"2ddglcn_p": -1.0, "2ddglcn_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "DDGLCNt2rpp", "gene_reaction_rule": "ECs4835"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "2-dehydro-3-deoxy-D-gluconate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DDGLCNtex"]}, "metabolites": {"2ddglcn_p": 1.0, "2ddglcn_e": -1.0}, "id": "DDGLCNtex", "gene_reaction_rule": "ECs1012 or ompN or ECs3104 or ECs0268"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-dehydro-3-deoxygluconokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DDGLK"]}, "metabolites": {"h_c": 1.0, "2ddglcn_c": -1.0, "2ddg6p_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "DDGLK", "gene_reaction_rule": "ECs4406"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DDPA"]}, "metabolites": {"pep_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0, "2dda7p_c": 1.0, "e4p_c": -1.0}, "id": "DDPA", "gene_reaction_rule": "ECs3464 or ECs0782 or ECs2411"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Deoxyguanylate kinase (dGMP:ATP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DGK1"]}, "metabolites": {"dgdp_c": 1.0, "dgmp_c": -1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "DGK1", "gene_reaction_rule": "ECs4523"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "DGMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DGMPtex"]}, "metabolites": {"dgmp_e": -1.0, "dgmp_p": 1.0}, "id": "DGMPtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Inner Membrane", "name": "Deoxyguanosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DGSNt2pp"]}, "metabolites": {"dgsn_c": 1.0, "dgsn_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "DGSNt2pp", "gene_reaction_rule": "ECs3840"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Deoxyguanosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DGSNtex"]}, "metabolites": {"dgsn_p": 1.0, "dgsn_e": -1.0}, "id": "DGSNtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHAD1"]}, "metabolites": {"h2o_c": 1.0, "23dhmb_c": -1.0, "3mob_c": 1.0}, "id": "DHAD1", "gene_reaction_rule": "ECs4705"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHAD2"]}, "metabolites": {"23dhmp_c": -1.0, "3mop_c": 1.0, "h2o_c": 1.0}, "id": "DHAD2", "gene_reaction_rule": "ECs4705"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Dihydroxyacetone phosphotransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHAPT"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "dhap_c": 1.0, "dha_c": -1.0}, "id": "DHAPT", "gene_reaction_rule": "ECs1705 and ECs1704 and ECs1703 and ECs3287 and ECs3288"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Dihydroxyacetone transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHAtex"]}, "metabolites": {"dha_e": -1.0, "dha_p": 1.0}, "id": "DHAtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Inner Membrane", "name": "Dihydroxyacetone transport via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHAtpp"]}, "metabolites": {"dha_p": -1.0, "dha_c": 1.0}, "id": "DHAtpp", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHBD"]}, "metabolites": {"23dhb_c": 1.0, "nadh_c": 1.0, "23ddhb_c": -1.0, "nad_c": -1.0, "h_c": 1.0}, "id": "DHBD", "gene_reaction_rule": "ECs0635"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2,3-dihydroxybenzoate adenylate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHBS"]}, "metabolites": {"23dhba_c": 1.0, "23dhb_c": -1.0, "ppi_c": 1.0, "h_c": -1.0, "atp_c": -1.0}, "id": "DHBS", "gene_reaction_rule": "ECs0633"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2,3-dihydroxybenzoylserine hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHBSH"]}, "metabolites": {"23dhb_c": 1.0, "ser__L_c": 1.0, "h2o_c": -1.0, "23dhbzs_c": -1.0}, "id": "DHBSH", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "2,3-dihydroxycinnamate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHCIND"]}, "metabolites": {"dhcinnm_c": 1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0, "cenchddd_c": -1.0}, "id": "DHCIND", "gene_reaction_rule": "ECs3407"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2,3-dihydroxycinnamate 1,2-dioxygenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHCINDO"]}, "metabolites": {"o2_c": -1.0, "hkntd_c": 1.0, "dhcinnm_c": -1.0, "h_c": 1.0}, "id": "DHCINDO", "gene_reaction_rule": "ECs0403"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Dihydrodipicolinate reductase (NADPH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHDPRy"]}, "metabolites": {"23dhdp_c": -1.0, "thdp_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0}, "id": "DHDPRy", "gene_reaction_rule": "ECs0034"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Dihydrodipicolinate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHDPS"]}, "metabolites": {"aspsa_c": -1.0, "pyr_c": -1.0, "23dhdp_c": 1.0, "h2o_c": 2.0, "h_c": 1.0}, "id": "DHDPS", "gene_reaction_rule": "ECs3340"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydrofolate reductase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHFR"]}, "metabolites": {"dhf_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "thf_c": 1.0, "h_c": -1.0}, "id": "DHFR", "gene_reaction_rule": "ECs2312 or ECs0051"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydrofolate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHFS"]}, "metabolites": {"dhf_c": 1.0, "atp_c": -1.0, "glu__L_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "dhpt_c": -1.0, "pi_c": 1.0}, "id": "DHFS", "gene_reaction_rule": "ECs3199"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydromonapterin reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHMPTR"]}, "metabolites": {"nadph_c": -1.0, "thmnp_c": 1.0, "nadp_c": 1.0, "dhmpt_c": -1.0, "h_c": -1.0}, "id": "DHMPTR", "gene_reaction_rule": "ECs2312"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "1,4-dihydroxy-2-naphthoate octaprenyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHNAOT4"]}, "metabolites": {"co2_c": 1.0, "octdp_c": -1.0, "ppi_c": 1.0, "2dmmql8_c": 1.0, "h_c": -1.0, "dhna_c": -1.0}, "id": "DHNAOT4", "gene_reaction_rule": "ECs4857"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "1,4-dihydroxy-2-napthoyl-CoA synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHNCOAS"]}, "metabolites": {"sbzcoa_c": -1.0, "h2o_c": 1.0, "h_c": -1.0, "14dhncoa_c": 1.0}, "id": "DHNCOAS", "gene_reaction_rule": "ECs3150"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "1,4-dihydroxy-2-napthoyl-CoA thioesterase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHNCOAT"]}, "metabolites": {"h2o_c": -1.0, "dhna_c": 1.0, "coa_c": 1.0, "h_c": 1.0, "14dhncoa_c": -1.0}, "id": "DHNCOAT", "gene_reaction_rule": "ECs0771"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydroneopterin aldolase reversible", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHNPA2r"]}, "metabolites": {"dhnpt_c": -1.0, "6hmhpt_c": 1.0, "gcald_c": 1.0}, "id": "DHNPA2r", "gene_reaction_rule": "ECs3941"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydroneopterin epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHNPTE"]}, "metabolites": {"dhnpt_c": -1.0, "dhmpt_c": 1.0}, "id": "DHNPTE", "gene_reaction_rule": "ECs3941"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Dihydoorotic acid dehydrogenase (quinone8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHORD2"]}, "metabolites": {"q8h2_c": 1.0, "dhor__S_c": -1.0, "q8_c": -1.0, "orot_c": 1.0}, "id": "DHORD2", "gene_reaction_rule": "ECs1029"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Dihydroorotic acid (menaquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHORD5"]}, "metabolites": {"dhor__S_c": -1.0, "mqn8_c": -1.0, "mql8_c": 1.0, "orot_c": 1.0}, "id": "DHORD5", "gene_reaction_rule": "ECs1029"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Fumarate dependent DHORD", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHORDfum"]}, "metabolites": {"succ_c": 1.0, "fum_c": -1.0, "dhor__S_c": -1.0, "orot_c": 1.0}, "id": "DHORDfum", "gene_reaction_rule": ""}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Dihydroorotase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHORTS"]}, "metabolites": {"cbasp_c": 1.0, "h2o_c": -1.0, "dhor__S_c": -1.0, "h_c": 1.0}, "id": "DHORTS", "gene_reaction_rule": "ECs1440"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2,3-dihydroxyphenylpropionate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPPD"]}, "metabolites": {"cechddd_c": -1.0, "dhpppn_c": 1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "DHPPD", "gene_reaction_rule": "ECs3407"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Diaminohydroxyphosphoribosylaminopryrimidine deaminase (25drapp)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPPDA2"]}, "metabolites": {"5apru_c": 1.0, "25drapp_c": -1.0, "h2o_c": -1.0, "nh4_c": 1.0, "h_c": -1.0}, "id": "DHPPDA2", "gene_reaction_rule": "ECs0467"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydropteroate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPS2"]}, "metabolites": {"dhpt_c": 1.0, "6hmhptpp_c": -1.0, "ppi_c": 1.0, "4abz_c": -1.0}, "id": "DHPS2", "gene_reaction_rule": "ECs4056"}, {"subsystem": "Methionine Metabolism", "name": "4,5-dihydroxy-2,3-pentanedione cyclization (spontaneous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPTDCs2"]}, "metabolites": {"dhptd_c": -1.0, "mdhdhf_c": 1.0}, "id": "DHPTDCs2", "gene_reaction_rule": "s0001"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Dihydropteridine reductase", "upper_bound": 0.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPTDNR"]}, "metabolites": {"dhptdn_c": -1.0, "thptdn_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -3.0}, "id": "DHPTDNR", "gene_reaction_rule": "ECs0616"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Dihydropteridine reductase (NADH)", "upper_bound": 0.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPTDNRN"]}, "metabolites": {"thptdn_c": 1.0, "dhptdn_c": -1.0, "nadh_c": -1.0, "h_c": -3.0, "nad_c": 1.0}, "id": "DHPTDNRN", "gene_reaction_rule": "ECs0616"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydroneopterin triphosphate 2'-epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHPTPE"]}, "metabolites": {"dhmptp_c": 1.0, "ahdt_c": -1.0}, "id": "DHPTPE", "gene_reaction_rule": "ECs3187"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "3-dehydroquinate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHQS"]}, "metabolites": {"2dda7p_c": -1.0, "pi_c": 1.0, "3dhq_c": 1.0}, "id": "DHQS", "gene_reaction_rule": "ECs4231"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "3-dehydroquinate dehydratase, irreversible", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHQTi"]}, "metabolites": {"3dhsk_c": 1.0, "h2o_c": 1.0, "3dhq_c": -1.0}, "id": "DHQTi", "gene_reaction_rule": "ECs2400"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "DIMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DIMPtex"]}, "metabolites": {"dimp_p": 1.0, "dimp_e": -1.0}, "id": "DIMPtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Inner Membrane", "name": "Deoxyinosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DINSt2pp"]}, "metabolites": {"din_p": -1.0, "din_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "DINSt2pp", "gene_reaction_rule": "ECs3840"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Deoxyinosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DINStex"]}, "metabolites": {"din_p": 1.0, "din_e": -1.0}, "id": "DINStex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2,5-diketo-D-gluconate reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DKGLCNR1"]}, "metabolites": {"25dkglcn_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "2dhguln_c": 1.0}, "id": "DKGLCNR1", "gene_reaction_rule": "ECs0203 or ECs3896"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2,5-diketo-D-gluconate reductase (NADH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DKGLCNR2x"]}, "metabolites": {"nad_c": 1.0, "25dkglcn_c": -1.0, "5dglcn_c": 1.0, "h_c": -1.0, "nadh_c": -1.0}, "id": "DKGLCNR2x", "gene_reaction_rule": "ECs4438"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2,5-diketo-D-gluconate reductase (NADPH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DKGLCNR2y"]}, "metabolites": {"nadph_c": -1.0, "25dkglcn_c": -1.0, "5dglcn_c": 1.0, 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Biosynthesis", "name": "Enoyl-[acyl-carrier-protein] reductase (NADH) (n-C4:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EAR40x"]}, "metabolites": {"butACP_c": 1.0, "but2eACP_c": -1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0}, "id": "EAR40x", "gene_reaction_rule": "ECs1861"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Enoyl-[acyl-carrier-protein] reductase (NADPH) (n-C4:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EAR40y"]}, "metabolites": {"butACP_c": 1.0, "but2eACP_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0}, "id": "EAR40y", "gene_reaction_rule": "ECs1861"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Enoyl-[acyl-carrier-protein] reductase (NADH) (n-C6:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EAR60x"]}, "metabolites": {"thex2eACP_c": -1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "hexACP_c": 1.0}, "id": "EAR60x", "gene_reaction_rule": "ECs1861"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Enoyl-[acyl-carrier-protein] reductase (NADPH) (n-C6:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EAR60y"]}, "metabolites": {"hexACP_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "thex2eACP_c": -1.0}, "id": "EAR60y", "gene_reaction_rule": "ECs1861"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Enoyl-[acyl-carrier-protein] reductase (NADH) (n-C8:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EAR80x"]}, "metabolites": {"ocACP_c": 1.0, "nad_c": 1.0, "nadh_c": -1.0, "h_c": -1.0, "toct2eACP_c": -1.0}, "id": "EAR80x", "gene_reaction_rule": "ECs1861"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Enoyl-[acyl-carrier-protein] reductase (NADPH) (n-C8:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EAR80y"]}, "metabolites": {"ocACP_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "toct2eACP_c": -1.0}, "id": "EAR80y", "gene_reaction_rule": "ECs1861"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Enterobacterial common antigen (x4) core oligosaccharide lipid A transport via ABC system (periplasm to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ECA4COLIPAabctex"]}, "metabolites": {"eca4colipa_e": 1.0, "h2o_c": -1.0, "atp_c": -1.0, "eca4colipa_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "ECA4COLIPAabctex", "gene_reaction_rule": "ECs4079 and ECs4080 and ECs4078 and ECs5238 and ECs5239"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Enterobacterial common antigen polymerase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ECAP1pp"]}, "metabolites": {"eca2und_p": 1.0, "unagamuf_p": -2.0, "udcpdp_p": 1.0, "h_p": 1.0}, "id": "ECAP1pp", "gene_reaction_rule": "ECs4727 and ECs4718"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Enterobacterial common antigen polymerase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ECAP2pp"]}, "metabolites": {"eca2und_p": -1.0, "unagamuf_p": -1.0, "eca3und_p": 1.0, "udcpdp_p": 1.0, "h_p": 1.0}, "id": "ECAP2pp", "gene_reaction_rule": "ECs4727 and ECs4718"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Enterobacterial common antigen polymerase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ECAP3pp"]}, "metabolites": {"unagamuf_p": -1.0, "eca4und_p": 1.0, "eca3und_p": -1.0, "udcpdp_p": 1.0, "h_p": 1.0}, "id": "ECAP3pp", "gene_reaction_rule": "ECs4727 and ECs4718"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Enterobacterial common antigen transferase (flippase, cytoplasm to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ECAtpp"]}, "metabolites": {"unagamuf_p": 1.0, "unagamuf_c": -1.0}, "id": "ECAtpp", "gene_reaction_rule": "ECs4725"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH1"]}, "metabolites": {"b2coa_c": 1.0, "3hbcoa_c": -1.0, "h2o_c": 1.0}, "id": "ECOAH1", "gene_reaction_rule": "ECs4774 or ECs3224"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxyhexanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH2"]}, "metabolites": {"3hhcoa_c": -1.0, "h2o_c": 1.0, "hx2coa_c": 1.0}, "id": "ECOAH2", "gene_reaction_rule": "ECs4774 or ECs3224"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxyoctanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH3"]}, "metabolites": {"oc2coa_c": 1.0, "h2o_c": 1.0, "3hocoa_c": -1.0}, "id": "ECOAH3", "gene_reaction_rule": "ECs4774 or ECs3224"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxydecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH4"]}, "metabolites": {"3hdcoa_c": -1.0, "h2o_c": 1.0, "dc2coa_c": 1.0}, "id": "ECOAH4", "gene_reaction_rule": "ECs4774 or ECs3224"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxydodecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH5"]}, "metabolites": {"h2o_c": 1.0, "3hddcoa_c": -1.0, "dd2coa_c": 1.0}, "id": "ECOAH5", "gene_reaction_rule": "ECs4774 or ECs3224"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxytetradecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH6"]}, "metabolites": {"h2o_c": 1.0, "3htdcoa_c": -1.0, "td2coa_c": 1.0}, "id": "ECOAH6", "gene_reaction_rule": "ECs4774 or ECs3224"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxyhexadecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH7"]}, "metabolites": {"h2o_c": 1.0, "hdd2coa_c": 1.0, "3hhdcoa_c": -1.0}, "id": "ECOAH7", "gene_reaction_rule": "ECs4774 or ECs3224"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxyoctadecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH8"]}, "metabolites": {"3hodcoa_c": -1.0, "od2coa_c": 1.0, "h2o_c": 1.0}, "id": "ECOAH8", "gene_reaction_rule": "ECs4774 or ECs3224"}, {"subsystem": "Pentose Phosphate Pathway", "name": "2-dehydro-3-deoxy-phosphogluconate aldolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EDA"]}, "metabolites": {"pyr_c": 1.0, "g3p_c": 1.0, "2ddg6p_c": -1.0}, "id": "EDA", "gene_reaction_rule": "ECs2560"}, {"subsystem": "Pentose Phosphate Pathway", "name": "6-phosphogluconate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EDD"]}, "metabolites": {"6pgc_c": -1.0, "h2o_c": 1.0, "2ddg6p_c": 1.0}, "id": "EDD", "gene_reaction_rule": "ECs2561"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Endotoxin Synthesis (lauroyl transferase)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EDTXS1"]}, "metabolites": {"kdo2lipid4_c": -1.0, "kdo2lipid4L_c": 1.0, "ACP_c": 1.0, "ddcaACP_c": -1.0}, "id": "EDTXS1", "gene_reaction_rule": "ECs1432"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Endotoxin Synthesis (myristoyl transferase)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EDTXS2"]}, "metabolites": {"kdo2lipid4L_c": -1.0, "ACP_c": 1.0, "lipa_c": 1.0, "myrsACP_c": -1.0}, "id": "EDTXS2", "gene_reaction_rule": "ECs2565"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Endotoxin Synthesis (palmitoleoyl ACP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EDTXS3"]}, "metabolites": {"kdo2lipid4_c": -1.0, "ACP_c": 1.0, "hdeACP_c": -1.0, "kdo2lipid4p_c": 1.0}, "id": "EDTXS3", "gene_reaction_rule": "ECs3258"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Endotoxin Synthesis (myristoyl transferase)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EDTXS4"]}, "metabolites": {"ACP_c": 1.0, "lipa_cold_c": 1.0, "kdo2lipid4p_c": -1.0, "myrsACP_c": -1.0}, "id": "EDTXS4", "gene_reaction_rule": "ECs2565"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Enoylglutaryl-[ACP] methyl ester reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EGMEACPR"]}, "metabolites": {"egmeACP_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "gmeACP_c": 1.0}, "id": "EGMEACPR", "gene_reaction_rule": "ECs1861"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Phosphoethanolamine lipid A transport via ABC system (periplasm to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ENLIPAabctex"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "enlipa_e": 1.0, "h_c": 1.0, "adp_c": 1.0, "enlipa_p": -1.0, "pi_c": 1.0}, "id": "ENLIPAabctex", "gene_reaction_rule": "ECs4079 and ECs4080 and ECs4078 and ECs5238 and ECs5239"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Enolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ENO"]}, "metabolites": {"pep_c": 1.0, "h2o_c": 1.0, "2pg_c": -1.0}, "id": "ENO", "gene_reaction_rule": "ECs3639"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Enterochelin synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ENTCS"]}, "metabolites": {"23dhba_c": -3.0, "seramp_c": -3.0, "amp_c": 6.0, "h_c": 9.0, "enter_c": 1.0}, "id": "ENTCS", "gene_reaction_rule": "ECs0622"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Enterochelin Esterase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ENTERES"]}, "metabolites": {"h2o_c": -3.0, "enter_c": -1.0, "h_c": 3.0, "23dhbzs_c": 3.0}, "id": "ENTERES", "gene_reaction_rule": "ECs0624"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Enterochelin Esterase (Fe containing)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ENTERES2"]}, "metabolites": {"fe3_c": 1.0, "h2o_c": -3.0, "feenter_c": -1.0, "h_c": 3.0, "23dhbzs_c": 3.0}, "id": "ENTERES2", "gene_reaction_rule": "ECs0624"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Enoylpimeloyl-[ACP] methyl ester reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EPMEACPR"]}, "metabolites": {"pmeACP_c": 1.0, "epmeACP_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0}, "id": "EPMEACPR", "gene_reaction_rule": "ECs1861"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Ethanolamine ammonia-lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ETHAAL"]}, "metabolites": {"acald_c": 1.0, "nh4_c": 1.0, "etha_c": -1.0}, "id": "ETHAAL", "gene_reaction_rule": "ECs3311 and ECs3312"}, {"subsystem": "Transport, Inner Membrane", "name": "Ethanolamine transport in via proton symport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ETHAt2pp"]}, "metabolites": {"etha_c": 1.0, "etha_p": -1.0, "h_p": -1.0, "h_c": 1.0}, "id": "ETHAt2pp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Ethanolamine transport via diffusion (extracellular)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ETHAtex"]}, "metabolites": {"etha_e": -1.0, "etha_p": 1.0}, "id": "ETHAtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Inner Membrane", "name": "Ethanesulfonate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ETHSO3abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "ethso3_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "ethso3_p": -1.0}, "id": "ETHSO3abcpp", "gene_reaction_rule": "ECs1019 and ECs1016 and ECs1017"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Ethanesulfonate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ETHSO3tex"]}, "metabolites": {"ethso3_e": -1.0, "ethso3_p": 1.0}, "id": "ETHSO3tex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Ethanol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ETOHtex"]}, "metabolites": {"etoh_e": -1.0, "etoh_p": 1.0}, "id": "ETOHtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Inner Membrane", "name": "Ethanol reversible transport via diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ETOHtrpp"]}, "metabolites": {"etoh_p": -1.0, "etoh_c": 1.0}, "id": "ETOHtrpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Fructose 6-phosphate aldolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["F6PA"]}, "metabolites": {"g3p_c": 1.0, "dha_c": 1.0, "f6p_c": -1.0}, "id": "F6PA", "gene_reaction_rule": "ECs0903 or ECs4875"}, {"subsystem": "Alternate Carbon Metabolism", "name": "D-fructose 6-phosphate phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["F6PP"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "fru_c": 1.0, "f6p_c": -1.0}, "id": "F6PP", "gene_reaction_rule": "ECs0899"}, {"subsystem": "Transport, Inner Membrane", "name": "Fructose-6-phosphate transport via phosphate antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["F6Pt6_2pp"]}, "metabolites": {"pi_p": 2.0, "pi_c": -2.0, "f6p_p": -1.0, "f6p_c": 1.0}, "id": "F6Pt6_2pp", "gene_reaction_rule": "ECs4603"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Fructose 6-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["F6Ptex"]}, "metabolites": {"f6p_e": -1.0, "f6p_p": 1.0}, "id": "F6Ptex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Fatty-acyl-ACP hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FA100ACPHi"]}, "metabolites": {"dcaACP_c": -1.0, "ACP_c": 1.0, "h_c": 1.0, "h2o_c": -1.0, "dca_c": 1.0}, "id": "FA100ACPHi", "gene_reaction_rule": "ECs0455"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Fatty-acyl-ACP hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FA120ACPHi"]}, "metabolites": {"ddca_c": 1.0, "h2o_c": -1.0, "ACP_c": 1.0, "h_c": 1.0, "ddcaACP_c": -1.0}, "id": "FA120ACPHi", "gene_reaction_rule": "ECs0455"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Fatty-acyl-ACP hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FA140ACPHi"]}, "metabolites": {"h2o_c": -1.0, "ACP_c": 1.0, "h_c": 1.0, "myrsACP_c": -1.0, "ttdca_c": 1.0}, "id": "FA140ACPHi", "gene_reaction_rule": "ECs0455"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Fatty-acyl-ACP hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FA141ACPHi"]}, "metabolites": {"tdeACP_c": -1.0, "h2o_c": -1.0, "ACP_c": 1.0, "h_c": 1.0, "ttdcea_c": 1.0}, "id": "FA141ACPHi", "gene_reaction_rule": "ECs0455"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Fatty-acyl-ACP hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FA160ACPHi"]}, "metabolites": {"h2o_c": -1.0, "ACP_c": 1.0, "hdca_c": 1.0, "h_c": 1.0, "palmACP_c": -1.0}, "id": "FA160ACPHi", "gene_reaction_rule": "ECs0455"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Fatty-acyl-ACP hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FA161ACPHi"]}, "metabolites": {"hdcea_c": 1.0, "h2o_c": -1.0, "ACP_c": 1.0, "hdeACP_c": -1.0, "h_c": 1.0}, "id": "FA161ACPHi", "gene_reaction_rule": "ECs0455"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Fatty-acyl-ACP hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FA80ACPHi"]}, "metabolites": {"h_c": 1.0, "h2o_c": -1.0, "ocACP_c": -1.0, "ACP_c": 1.0, "octa_c": 1.0}, "id": "FA80ACPHi", "gene_reaction_rule": "ECs0455"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Fatty-acid-CoA thioesterase (decanoate)", 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Prosthetic Group Biosynthesis", "name": "FMN reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FMNRx"]}, "metabolites": {"fmnh2_c": 1.0, "nadh_c": -1.0, "fmn_c": -1.0, "h_c": -1.0, "nad_c": 1.0}, "id": "FMNRx", "gene_reaction_rule": "ECs1020 or ECs4772"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "FMN reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FMNRx2"]}, "metabolites": {"fmnh2_c": 1.0, "nadph_c": -1.0, "nadp_c": 1.0, "fmn_c": -1.0, "h_c": -1.0}, "id": "FMNRx2", "gene_reaction_rule": "ECs4772 or ECs1020 or (ECs3618 and ECs3619)"}, {"subsystem": "Folate Metabolism", "name": "Aminomethyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FOMETRi"]}, "metabolites": {"5fthf_c": -1.0, "h2o_c": 1.0, "h_c": -1.0, "methf_c": 1.0}, "id": "FOMETRi", "gene_reaction_rule": "ECs3782"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Formyl-CoA 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(cytoplasm to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FORtppi"]}, "metabolites": {"for_p": 1.0, "for_c": -1.0}, "id": "FORtppi", "gene_reaction_rule": "ECs0987 or ECs3354"}, {"subsystem": "Citric Acid Cycle", "name": "Fumarate reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FRD2"]}, "metabolites": {"succ_c": 1.0, "fum_c": -1.0, "mqn8_c": 1.0, "mql8_c": -1.0}, "id": "FRD2", "gene_reaction_rule": "ECs5132 and ECs5133 and ECs5134 and ECs5135"}, {"subsystem": "Citric Acid Cycle", "name": "Fumarate reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FRD3"]}, "metabolites": {"succ_c": 1.0, "fum_c": -1.0, "2dmmq8_c": 1.0, "2dmmql8_c": -1.0}, "id": "FRD3", "gene_reaction_rule": "ECs5132 and ECs5133 and ECs5134 and ECs5135"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Fructose-1-phosphate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FRUK"]}, "metabolites": {"h_c": 1.0, "f1p_c": -1.0, "fdp_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "FRUK", "gene_reaction_rule": "ECs3060"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Fructoselysine phosphate deglycase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FRULYSDG"]}, "metabolites": {"g6p_c": 1.0, "lys__L_c": 1.0, "h2o_c": -1.0, "frulysp_c": -1.0}, "id": "FRULYSDG", "gene_reaction_rule": "ECs4222"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Fructoselysine 3-epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FRULYSE"]}, "metabolites": {"frulys_c": 1.0, "psclys_c": -1.0}, "id": "FRULYSE", "gene_reaction_rule": "ECs4223"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Fructoselysine Kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FRULYSK"]}, "metabolites": {"frulys_c": -1.0, "frulysp_c": 1.0, "atp_c": -1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "FRULYSK", "gene_reaction_rule": "ECs4224"}, {"subsystem": "Transport, Inner Membrane", "name": "Fructoselysine transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FRULYSt2pp"]}, "metabolites": {"frulys_c": 1.0, "frulys_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "FRULYSt2pp", "gene_reaction_rule": "ECs4221"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Fructoselysine transporter via diffusion (extracellular)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FRULYStex"]}, "metabolites": {"frulys_p": 1.0, "frulys_e": -1.0}, "id": "FRULYStex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Inner Membrane", "name": "D-fructuronate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FRUURt2rpp"]}, "metabolites": {"h_c": 1.0, "fruur_p": -1.0, "h_p": -1.0, "fruur_c": 1.0}, "id": "FRUURt2rpp", "gene_reaction_rule": "ECs5280"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-fructuronate transport via diffusion (extracellular)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FRUURtex"]}, "metabolites": {"fruur_e": -1.0, "fruur_p": 1.0}, "id": "FRUURtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Inner Membrane", "name": "Fructose transport via PEP:Pyr PTS (f6p generating) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FRUpts2pp"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "fru_p": -1.0, "f6p_c": 1.0}, "id": "FRUpts2pp", "gene_reaction_rule": "ECs2527 and ECs2528 and ECs2529 and ECs3287 and ECs3288"}, {"subsystem": "Transport, Inner Membrane", "name": "D-fructose transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": 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-1.0, "fum_c": -1.0, "mal__L_c": 1.0}, "id": "FUM", "gene_reaction_rule": "ECs2318 or ECs2317"}, {"subsystem": "Transport, Inner Membrane", "name": "Fumarate transport via proton symport (2 H) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FUMt2_2pp"]}, "metabolites": {"fum_p": -1.0, "fum_c": 1.0, "h_c": 2.0, "h_p": -2.0}, "id": "FUMt2_2pp", "gene_reaction_rule": "ECs4408"}, {"subsystem": "Transport, Inner Membrane", "name": "Fumarate transport via proton symport (3 H) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FUMt2_3pp"]}, "metabolites": {"fum_p": -1.0, "fum_c": 1.0, "h_c": 3.0, "h_p": -3.0}, "id": "FUMt2_3pp", "gene_reaction_rule": "ECs5119 or ECs5105 or ECs0660"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Fumarate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FUMtex"]}, "metabolites": 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-1.0, "coa_c": 1.0, "h_c": 1.0, "accoa_c": -1.0, "acgam1p_c": 1.0}, "id": "G1PACT", "gene_reaction_rule": "ECs4672"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Glucose-1-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G1PPpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "glc__D_p": 1.0, "g1p_p": -1.0}, "id": "G1PPpp", "gene_reaction_rule": "ECs1158"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Glucose-1-phosphate thymidylyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G1PTT"]}, "metabolites": {"dtdpglu_c": 1.0, "ppi_c": 1.0, "dttp_c": -1.0, "h_c": -1.0, "g1p_c": -1.0}, "id": "G1PTT", "gene_reaction_rule": "ECs4722"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-glucose 1-phosphate transport via diffusion", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G1Ptex"]}, "metabolites": {"g1p_e": -1.0, "g1p_p": 1.0}, "id": "G1Ptex", 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{"subsystem": "Transport, Outer Membrane Porin", "name": "Glycero-3-phosphoethanolamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G3PEtex"]}, "metabolites": {"g3pe_e": -1.0, "g3pe_p": 1.0}, "id": "G3PEtex", "gene_reaction_rule": "ECs1012 or ompN or ECs3104 or ECs0268"}, {"subsystem": "Transport, Inner Membrane", "name": "Sn-glycerol-3-phosphoglycerol transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PGabcpp"]}, "metabolites": {"g3pg_p": -1.0, "atp_c": -1.0, "h2o_c": -1.0, "g3pg_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "G3PGabcpp", "gene_reaction_rule": "ECs4298 and ECs4299 and ECs4296 and ECs4297"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glycerophoglycerol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G3PGtex"]}, "metabolites": {"g3pg_p": 1.0, "g3pg_e": -1.0}, "id": "G3PGtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Inner Membrane", "name": "Sn-glycerol-3-phosphoethanolamine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PIabcpp"]}, "metabolites": {"g3pi_p": -1.0, "h2o_c": -1.0, "atp_c": -1.0, "g3pi_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "G3PIabcpp", "gene_reaction_rule": "ECs4298 and ECs4299 and ECs4296 and ECs4297"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glycero-3-phospho-1-inositol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G3PItex"]}, "metabolites": {"g3pi_p": 1.0, "g3pi_e": -1.0}, "id": "G3PItex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Inner Membrane", "name": "Sn-glycerol-3-phosphoserine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PSabcpp"]}, "metabolites": {"h2o_c": -1.0, "g3ps_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "g3ps_p": -1.0, "pi_c": 1.0}, "id": "G3PSabcpp", "gene_reaction_rule": "ECs4298 and ECs4299 and ECs4296 and ECs4297"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glycerophosphserine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G3PStex"]}, "metabolites": {"g3ps_e": -1.0, "g3ps_p": 1.0}, "id": "G3PStex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glycerol-3-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G3PT"]}, "metabolites": {"glyc3p_c": -1.0, "pi_c": 1.0, "h2o_c": -1.0, "glyc_c": 1.0}, "id": "G3PT", "gene_reaction_rule": "ECs0899"}, {"subsystem": "Arginine and Proline Metabolism", "name": "L-glutamate 5-semialdehyde dehydratase (spontaneous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G5SADs"]}, "metabolites": {"1pyr5c_c": 1.0, "glu5sa_c": -1.0, "h2o_c": 1.0, "h_c": 1.0}, "id": "G5SADs", "gene_reaction_rule": "s0001"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Glutamate-5-semialdehyde dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G5SD"]}, "metabolites": {"glu5sa_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "pi_c": 1.0, "glu5p_c": -1.0}, "id": "G5SD", "gene_reaction_rule": "ECs0270"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glucosamine-6-phosphate deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G6PDA"]}, "metabolites": {"gam6p_c": -1.0, "nh4_c": 1.0, "h2o_c": -1.0, "f6p_c": 1.0}, "id": "G6PDA", "gene_reaction_rule": "ECs0708"}, {"subsystem": "Pentose Phosphate Pathway", "name": "Glucose 6-phosphate dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G6PDH2r"]}, "metabolites": {"nadph_c": 1.0, "g6p_c": -1.0, "6pgl_c": 1.0, "nadp_c": -1.0, "h_c": 1.0}, "id": "G6PDH2r", "gene_reaction_rule": "ECs2562"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Glucose-6-phosphate phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G6PP"]}, "metabolites": {"glc__D_c": 1.0, "g6p_c": -1.0, "pi_c": 1.0, "h2o_c": -1.0}, "id": "G6PP", "gene_reaction_rule": "ECs0899"}, {"subsystem": "Transport, Inner Membrane", "name": "Glucose-6-phosphate transport via phosphate antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["G6Pt6_2pp"]}, "metabolites": {"pi_p": 2.0, "g6p_p": -1.0, "g6p_c": 1.0, "pi_c": -2.0}, "id": "G6Pt6_2pp", "gene_reaction_rule": "ECs4603"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glucose 6-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["G6Ptex"]}, "metabolites": {"g6p_p": 1.0, "g6p_e": -1.0}, "id": "G6Ptex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Alternate Carbon Metabolism", "name": "D-galactose 1-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GAL1PPpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "gal_p": 1.0, "gal1p_p": -1.0}, "id": "GAL1PPpp", "gene_reaction_rule": "ECs1158"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-galactose 1-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GAL1Ptex"]}, "metabolites": {"gal1p_e": -1.0, "gal1p_p": 1.0}, "id": "GAL1Ptex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Outer Membrane 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via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALCTNLt2pp"]}, "metabolites": {"galctn__L_c": 1.0, "galctn__L_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GALCTNLt2pp", "gene_reaction_rule": "ECs5316"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-galactonate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALCTNLtex"]}, "metabolites": {"galctn__L_p": 1.0, "galctn__L_e": -1.0}, "id": "GALCTNLtex", "gene_reaction_rule": "ECs3104 or ompN or ECs1012 or ECs0268"}, {"subsystem": "Transport, Inner Membrane", "name": "D-galactonate transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALCTNt2pp"]}, "metabolites": {"galctn__D_c": 1.0, "galctn__D_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GALCTNt2pp", "gene_reaction_rule": "dgoT"}, {"subsystem": "Transport, Outer 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transformylase-T", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GART"]}, "metabolites": {"adp_c": 1.0, "atp_c": -1.0, "fgam_c": 1.0, "h_c": 1.0, "for_c": -1.0, "gar_c": -1.0, "pi_c": 1.0}, "id": "GART", "gene_reaction_rule": "ECs2559"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Gamma-butyrobetaine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GBBTNtex"]}, "metabolites": {"gbbtn_e": -1.0, "gbbtn_p": 1.0}, "id": "GBBTNtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Folate Metabolism", "name": "Glycolaldehyde dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GCALDD"]}, "metabolites": {"h2o_c": -1.0, "glyclt_c": 1.0, "h_c": 2.0, "nad_c": -1.0, "nadh_c": 1.0, "gcald_c": -1.0}, "id": "GCALDD", "gene_reaction_rule": "ECs2021"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "GDP-4-dehydro-6-deoxy-D-mannose epimerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GDMANE"]}, "metabolites": {"gdpddman_c": -1.0, "gdpofuc_c": 1.0}, "id": "GDMANE", "gene_reaction_rule": "ECs2857"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "GDP diphosphokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GDPDPK"]}, "metabolites": {"ppgpp_c": 1.0, "gdp_c": -1.0, "amp_c": 1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "GDPDPK", "gene_reaction_rule": "ECs3644 or ECs4525"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "GDP-mannose mannosyl hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GDPMNH"]}, "metabolites": {"h2o_c": -1.0, "gdp_c": 1.0, "h_c": 1.0, "gdpmann_c": -1.0, "man_c": 1.0}, "id": "GDPMNH", "gene_reaction_rule": "ECs2856"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "GDP-mannose phyrophosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GDPMNP"]}, "metabolites": {"gdpmann_c": -1.0, "gmp_c": 1.0, "man1p_c": 1.0, "h_c": 2.0, "h2o_c": -1.0}, "id": "GDPMNP", "gene_reaction_rule": "ECs3329"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Guanosine 3'-diphosphate 5'-triphosphate 3'-diphosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GDPTPDP"]}, "metabolites": {"gdptp_c": -1.0, "ppi_c": 1.0, "gtp_c": 1.0, "h2o_c": -1.0}, "id": "GDPTPDP", "gene_reaction_rule": "ECs4525"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "GDP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GDPtex"]}, "metabolites": {"gdp_e": -1.0, "gdp_p": 1.0}, "id": "GDPtex", "gene_reaction_rule": "ompN or ECs3104 or ECs1012 or ECs0268"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Glutamine-fructose-6-phosphate transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GF6PTA"]}, "metabolites": {"glu__L_c": 1.0, "f6p_c": -1.0, "gam6p_c": 1.0, "gln__L_c": -1.0}, "id": "GF6PTA", "gene_reaction_rule": "ECs4671"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Gamma-glutamyl-gamma aminobutyric acid dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GGGABADr"]}, "metabolites": {"h2o_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "gg4abut_c": 1.0, "h_c": 2.0, "ggbutal_c": -1.0}, "id": "GGGABADr", "gene_reaction_rule": "ECs1877"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Gamma-glutamyl-gamma-aminobutyric acid hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GGGABAH"]}, "metabolites": {"glu__L_c": 1.0, "gg4abut_c": -1.0, "h2o_c": -1.0, "4abut_c": 1.0}, "id": "GGGABAH", "gene_reaction_rule": "ECs1875"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Gamma glutamyl putrescine oxidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GGPTRCO"]}, "metabolites": {"o2_c": -1.0, "h2o_c": -1.0, "ggptrc_c": -1.0, "h2o2_c": 1.0, "nh4_c": 1.0, "ggbutal_c": 1.0}, "id": "GGPTRCO", "gene_reaction_rule": "ECs1878"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Gamma glutamyl putrescine synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GGPTRCS"]}, "metabolites": {"atp_c": -1.0, "ggptrc_c": 1.0, "glu__L_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "ptrc_c": -1.0, "pi_c": 1.0}, "id": "GGPTRCS", "gene_reaction_rule": "ECs1874"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Gamma-hydroxybutyrate dehydrogenase (NADH)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GHBDHx"]}, "metabolites": {"nad_c": 1.0, "nadh_c": -1.0, "h_c": -1.0, "ghb_c": 1.0, "sucsal_c": -1.0}, "id": "GHBDHx", "gene_reaction_rule": "ECs4805"}, {"subsystem": "Glycine and Serine Metabolism", "name": "Glycine hydroxymethyltransferase, reversible", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GHMT2r"]}, "metabolites": {"mlthf_c": 1.0, "ser__L_c": -1.0, "thf_c": -1.0, "h2o_c": 1.0, "gly_c": 1.0}, "id": "GHMT2r", "gene_reaction_rule": "ECs3417"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Guanylate kinase (GMP:ATP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GK1"]}, "metabolites": {"gmp_c": -1.0, "gdp_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "GK1", "gene_reaction_rule": "ECs4523"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "1,4-alpha-glucan branching enzyme (glycogen -> bglycogen)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLBRAN2"]}, "metabolites": {"bglycogen_c": 1.0, "glycogen_c": -1.0}, "id": "GLBRAN2", "gene_reaction_rule": "ECs4277"}, {"subsystem": "Alternate Carbon Metabolism", "name": "D-glucose O-acetyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCATr"]}, "metabolites": {"glc__D_c": -1.0, "acglc__D_c": 1.0, "coa_c": 1.0, "accoa_c": -1.0}, "id": "GLCATr", "gene_reaction_rule": "ECs0512"}, {"subsystem": "Oxidative Phosphorylation", "name": "Glucose dehydrogenase (ubiquinone-8 as acceptor) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCDpp"]}, "metabolites": {"glcn_p": 1.0, "h_p": 1.0, "q8h2_c": 1.0, "glc__D_p": -1.0, "h2o_p": -1.0, "q8_c": -1.0}, "id": "GLCDpp", "gene_reaction_rule": "ECs0128 or ECs0917"}, {"subsystem": "Transport, Inner Membrane", "name": "D-gluconate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCNt2rpp"]}, "metabolites": {"glcn_p": -1.0, "glcn_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GLCNt2rpp", "gene_reaction_rule": "ECs5280 or ECs4285 or ECs4257"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-gluconate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCNtex"]}, "metabolites": {"glcn_p": 1.0, "glcn_e": -1.0}, "id": "GLCNtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Glycogen phosphorylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCP"]}, "metabolites": {"pi_c": -1.0, "glycogen_c": -1.0, "g1p_c": 1.0}, "id": "GLCP", "gene_reaction_rule": "ECs4259"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Glycogen phosphorylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCP2"]}, "metabolites": {"bglycogen_c": -1.0, "pi_c": -1.0, "g1p_c": 1.0}, "id": "GLCP2", "gene_reaction_rule": "ECs4259"}, {"subsystem": "Alternate Carbon Metabolism", "name": "5-dehydro-4-deoxyglucarate aldolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCRAL"]}, "metabolites": {"pyr_c": 1.0, "5dh4dglc_c": -1.0, "2h3oppan_c": 1.0}, "id": "GLCRAL", "gene_reaction_rule": "ECs4004"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glucarate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCRD"]}, "metabolites": {"h2o_c": 1.0, "5dh4dglc_c": 1.0, "glcr_c": -1.0}, "id": "GLCRD", "gene_reaction_rule": "ECs3648 or ECs3647"}, {"subsystem": "Transport, Inner Membrane", "name": "D-glucarate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCRt2rpp"]}, "metabolites": {"h_c": 1.0, "glcr_p": -1.0, "h_p": -1.0, "glcr_c": 1.0}, "id": "GLCRt2rpp", "gene_reaction_rule": "ECs4005 or ECs3649"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-glucarate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCRtex"]}, "metabolites": {"glcr_e": -1.0, "glcr_p": 1.0}, "id": "GLCRtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Glycogen synthase (ADPGlc)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCS1"]}, "metabolites": {"adp_c": 1.0, "h_c": 1.0, "glycogen_c": 1.0, "adpglc_c": -1.0}, "id": "GLCS1", "gene_reaction_rule": "ECs4274"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Glucosyltransferase I (LPS core synthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCTR1"]}, "metabolites": {"icolipa_c": -1.0, "udp_c": 1.0, "udpg_c": -1.0, "h_c": 1.0, "gicolipa_c": 1.0}, "id": "GLCTR1", "gene_reaction_rule": "ECs4506"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-glucuronate 1-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCUR1Ptex"]}, "metabolites": {"glcur1p_p": 1.0, "glcur1p_e": -1.0}, "id": "GLCUR1Ptex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Inner Membrane", "name": "D-glucuronate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCURt2rpp"]}, "metabolites": {"glcur_c": 1.0, "h_c": 1.0, "h_p": -1.0, "glcur_p": -1.0}, "id": "GLCURt2rpp", "gene_reaction_rule": "ECs4835 or ECs3975"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-glucuronat transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCURtex"]}, "metabolites": {"glcur_e": -1.0, "glcur_p": 1.0}, "id": "GLCURtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Inner Membrane", "name": "D-glucose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "glc__D_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "glc__D_c": 1.0, "pi_c": 1.0}, "id": "GLCabcpp", "gene_reaction_rule": "ECs3041 and ECs3042 and ECs3040"}, {"subsystem": "Transport, Inner Membrane", "name": "D-glucose transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCptspp"]}, "metabolites": {"pep_c": -1.0, "g6p_c": 1.0, "glc__D_p": -1.0, "pyr_c": 1.0}, "id": "GLCptspp", "gene_reaction_rule": "(ECs3289 and ECs2329 and ECs3287 and ECs3288) or (ECs3289 and ECs1479 and ECs3287 and ECs3288) or (ECs2527 and ECs2528 and ECs2529 and ECs3287 and ECs3288)"}, {"subsystem": "Transport, Inner Membrane", "name": "D-glucose transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCt2pp"]}, "metabolites": {"glc__D_c": 1.0, "glc__D_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GLCt2pp", "gene_reaction_rule": "ECs3819"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glucose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCtex", "GLCtexi"]}, "metabolites": {"glc__D_p": 1.0, "glc__D_e": -1.0}, "id": "GLCtex_copy1", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Outer Membrane", "name": "Glucose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCtex", "GLCtexi"]}, "metabolites": {"glc__D_p": 1.0, "glc__D_e": -1.0}, "id": "GLCtex_copy2", "gene_reaction_rule": "ECs5019"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Glycogen debranching enzyme (bglycogen -> glycogen)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLDBRAN2"]}, "metabolites": {"bglycogen_c": -1.0, "glycogen_c": 1.0}, "id": "GLDBRAN2", "gene_reaction_rule": "ECs4276"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Glucose-1-phosphate adenylyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLGC"]}, "metabolites": {"h_c": -1.0, "ppi_c": 1.0, "adpglc_c": 1.0, "atp_c": -1.0, "g1p_c": -1.0}, "id": "GLGC", "gene_reaction_rule": "ECs4275"}, {"subsystem": "Glutamate Metabolism", "name": "Glutamine synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLNS"]}, "metabolites": {"atp_c": -1.0, "glu__L_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "nh4_c": -1.0, "gln__L_c": 1.0}, "id": "GLNS", "gene_reaction_rule": "ECs4792 or ECs1874"}, {"subsystem": "tRNA Charging", "name": "Glutaminyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLNTRS"]}, "metabolites": {"glntrna_c": 1.0, "atp_c": -1.0, "trnagln_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "gln__L_c": -1.0}, "id": "GLNTRS", "gene_reaction_rule": "ECs0710"}, {"subsystem": "Transport, Inner Membrane", "name": "L-glutamine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLNabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "gln__L_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "gln__L_c": 1.0}, "id": "GLNabcpp", "gene_reaction_rule": "ECs0889 and ECs0888 and ECs0887"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-glutamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLNtex"]}, "metabolites": {"gln__L_e": -1.0, "gln__L_p": 1.0}, "id": "GLNtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Galactitol-1-phosphate dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLTPD"]}, "metabolites": {"nadh_c": 1.0, "tag6p__D_c": 1.0, "galt1p_c": -1.0, 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ECs2131"}, {"subsystem": "Glutamate Metabolism", "name": "Glutaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUNpp"]}, "metabolites": {"h2o_p": -1.0, "gln__L_p": -1.0, "nh4_p": 1.0, "glu__L_p": 1.0}, "id": "GLUNpp", "gene_reaction_rule": "ECs3833"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Glutamine phosphoribosyldiphosphate amidotransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUPRT"]}, "metabolites": {"pram_c": 1.0, "h2o_c": -1.0, "glu__L_c": 1.0, "ppi_c": 1.0, "prpp_c": -1.0, "gln__L_c": -1.0}, "id": "GLUPRT", "gene_reaction_rule": "ECs3196"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Glutamate racemase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLUR"]}, "metabolites": {"glu__L_c": 1.0, "glu__D_c": -1.0}, "id": "GLUR", "gene_reaction_rule": "ECs4898"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Glutamyl-tRNA 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and ECs0691"}, {"subsystem": "Transport, Inner Membrane", "name": "L-glutamate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLUt2rpp"]}, "metabolites": {"glu__L_p": -1.0, "glu__L_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GLUt2rpp", "gene_reaction_rule": "ECs5059"}, {"subsystem": "Transport, Inner Membrane", "name": "Na+/glutamate symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUt4pp"]}, "metabolites": {"na1_p": -1.0, "glu__L_p": -1.0, "glu__L_c": 1.0, "na1_c": 1.0}, "id": "GLUt4pp", "gene_reaction_rule": "ECs4529"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-glutamate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLUtex"]}, "metabolites": {"glu__L_p": 1.0, "glu__L_e": -1.0}, "id": "GLUtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or 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"gene_reaction_rule": "ECs2510 or ECs5093"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glycine betaine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYBtex"]}, "metabolites": {"glyb_e": -1.0, "glyb_p": 1.0}, "id": "GLYBtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Inner Membrane", "name": "Sn-Glycerol 2-phosphate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYC2Pabcpp"]}, "metabolites": {"h2o_c": -1.0, "glyc2p_c": 1.0, "atp_c": -1.0, "glyc2p_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "GLYC2Pabcpp", "gene_reaction_rule": "ECs4298 and ECs4299 and ECs4296 and ECs4297"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glycerol-2-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYC2Ptex"]}, "metabolites": {"glyc2p_e": -1.0, "glyc2p_p": 1.0}, "id": "GLYC2Ptex", "gene_reaction_rule": "ECs3104 or ECs0268 or ECs1012 or ompN"}, {"subsystem": "Transport, Inner Membrane", "name": "Sn-Glycerol 3-phosphate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYC3Pabcpp"]}, "metabolites": {"glyc3p_c": 1.0, "atp_c": -1.0, "h2o_c": -1.0, "glyc3p_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "GLYC3Pabcpp", "gene_reaction_rule": "ECs4298 and ECs4299 and ECs4296 and ECs4297"}, {"subsystem": "Transport, Inner Membrane", "name": "Glycerol-3-phosphate : phosphate antiporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYC3Pt6pp"]}, "metabolites": {"pi_p": 1.0, "glyc3p_p": -1.0, "glyc3p_c": 1.0, "pi_c": -1.0}, "id": "GLYC3Pt6pp", "gene_reaction_rule": "ECs3125"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glycerol-3-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYC3Ptex"]}, "metabolites": {"glyc3p_p": 1.0, "glyc3p_e": -1.0}, "id": "GLYC3Ptex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Inner Membrane", "name": "D-glycerate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYCAt2rpp"]}, "metabolites": {"glyc__R_c": 1.0, "h_c": 1.0, "h_p": -1.0, "glyc__R_p": -1.0}, "id": "GLYCAt2rpp", "gene_reaction_rule": "ECs3649 or ECs4005"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-glycerate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYCAtex"]}, "metabolites": {"glyc__R_e": -1.0, "glyc__R_p": 1.0}, "id": "GLYCAtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glycerol dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCDx"]}, "metabolites": {"nad_c": -1.0, "nadh_c": 1.0, "glyc_c": -1.0, "dha_c": 1.0, "h_c": 1.0}, "id": "GLYCDx", "gene_reaction_rule": "ECs4874"}, {"subsystem": "Glyoxylate Metabolism", "name": "Glycerate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCK"]}, "metabolites": {"3pg_c": 1.0, "glyc__R_c": -1.0, "atp_c": -1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "GLYCK", "gene_reaction_rule": "ECs0576"}, {"subsystem": "Glycine and Serine Metabolism", "name": "Glycerate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCK2"]}, "metabolites": {"2pg_c": 1.0, "glyc__R_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "GLYCK2", "gene_reaction_rule": "ECs4002"}, {"subsystem": "Folate Metabolism", "name": "Glycine Cleavage System", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCL"]}, "metabolites": {"co2_c": 1.0, "mlthf_c": 1.0, "nh4_c": 1.0, "thf_c": -1.0, "nad_c": -1.0, "nadh_c": 1.0, "gly_c": -1.0}, "id": "GLYCL", "gene_reaction_rule": "ECs3775 and ECs3774 and ECs3776 and ECs0120"}, {"subsystem": "Glyoxylate Metabolism", "name": "Glycolate dehydrogenase (NAD)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCLTDx"]}, "metabolites": {"glyclt_c": 1.0, "glx_c": -1.0, "nadh_c": -1.0, "nad_c": 1.0, "h_c": -1.0}, "id": "GLYCLTDx", "gene_reaction_rule": "ECs4438 or ECs1410"}, {"subsystem": "Glyoxylate Metabolism", "name": "Glycolate dehydrogenase (NADP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCLTDy"]}, "metabolites": {"glyclt_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "glx_c": -1.0}, "id": "GLYCLTDy", "gene_reaction_rule": "ECs1410 or ECs4438"}, {"subsystem": "Transport, Inner Membrane", "name": "Glycolate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYCLTt2rpp"]}, "metabolites": {"glyclt_p": -1.0, "glyclt_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GLYCLTt2rpp", "gene_reaction_rule": "ECs4481"}, {"subsystem": "Transport, Inner Membrane", "name": "Glycolate transport via sodium symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCLTt4pp"]}, "metabolites": {"glyclt_p": -1.0, "na1_p": -1.0, "na1_c": 1.0, "glyclt_c": 1.0}, "id": "GLYCLTt4pp", "gene_reaction_rule": "ECs5049"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glycolate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYCLTtex"]}, "metabolites": {"glyclt_p": 1.0, "glyclt_e": -1.0}, "id": "GLYCLTtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glycerol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYCtex"]}, "metabolites": {"glyc_e": -1.0, "glyc_p": 1.0}, "id": "GLYCtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Inner Membrane", "name": "Glycerol transport via channel (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYCtpp"]}, "metabolites": {"glyc_c": -1.0, "glyc_p": 1.0}, "id": "GLYCtpp", "gene_reaction_rule": "ECs4852 or s0001"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glycerol kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYK"]}, "metabolites": {"glyc3p_c": 1.0, "glyc_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "GLYK", "gene_reaction_rule": "ECs4851"}, {"subsystem": "Methylglyoxal Metabolism", "name": "Hydroxyacylglutathione hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYOX"]}, "metabolites": {"lac__D_c": 1.0, "h2o_c": -1.0, "gthrd_c": 1.0, "h_c": 1.0, "lgt__S_c": -1.0}, "id": "GLYOX", "gene_reaction_rule": "ECs0208"}, {"subsystem": "Methylglyoxal Metabolism", "name": "Glyoxalase III", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYOX3"]}, "metabolites": {"h2o_c": -1.0, "lac__D_c": 1.0, "h_c": 1.0, "mthgxl_c": -1.0}, "id": "GLYOX3", "gene_reaction_rule": ""}, {"subsystem": "tRNA Charging", "name": "Glycyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYTRS"]}, "metabolites": {"glytrna_c": 1.0, "atp_c": -1.0, "ppi_c": 1.0, "trnagly_c": -1.0, "amp_c": 1.0, "gly_c": -1.0}, "id": "GLYTRS", "gene_reaction_rule": "ECs4442 and ECs4443"}, {"subsystem": "Transport, Inner Membrane", "name": "Glycine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, 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"lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYtex"]}, "metabolites": {"gly_e": -1.0, "gly_p": 1.0}, "id": "GLYtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "GDP-D-mannose dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GMAND"]}, "metabolites": {"gdpmann_c": -1.0, "gdpddman_c": 1.0, "h2o_c": 1.0}, "id": "GMAND", "gene_reaction_rule": "ECs2858"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "D-glycero-D-manno-hepose 1-phosphate adenyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GMHEPAT"]}, "metabolites": {"ppi_c": 1.0, "gmhep1p_c": -1.0, "adphep_DD_c": 1.0, "h_c": -1.0, "atp_c": -1.0}, "id": "GMHEPAT", "gene_reaction_rule": "ECs3935"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "D-glycero-D-manno-heptose 7-phosphate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GMHEPK"]}, "metabolites": {"adp_c": 1.0, "gmhep17bp_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "gmhep7p_c": -1.0}, "id": "GMHEPK", "gene_reaction_rule": "ECs3935"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GMHEPPA"]}, "metabolites": {"gmhep1p_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0, "gmhep17bp_c": -1.0}, "id": "GMHEPPA", "gene_reaction_rule": "ECs0202"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "GMP reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GMPR"]}, "metabolites": {"gmp_c": -1.0, "nadph_c": -1.0, "nh4_c": 1.0, "nadp_c": 1.0, "h_c": -2.0, "imp_c": 1.0}, "id": "GMPR", "gene_reaction_rule": "ECs0108"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "GMP synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": 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"notes": {"original_bigg_ids": ["GNK"]}, "metabolites": {"6pgc_c": 1.0, "glcn_c": -1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "GNK", "gene_reaction_rule": "ECs4286"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "GDP-4-oxo-L-fucose reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GOFUCR"]}, "metabolites": {"gdpfuc_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "gdpofuc_c": -1.0}, "id": "GOFUCR", "gene_reaction_rule": "ECs2857"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Gp4G hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GP4GH"]}, "metabolites": {"gp4g_c": -1.0, "gdp_c": 2.0, "h_c": 2.0, "h2o_c": -1.0}, "id": "GP4GH", "gene_reaction_rule": "ECs0054"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GPDDA1"]}, "metabolites": 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"Glycerophospholipid Metabolism", "name": "Glycerophosphodiester phosphodiesterase (Glycerophosphoinositol)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GPDDA5pp"]}, "metabolites": {"g3pi_p": -1.0, "glyc3p_p": 1.0, "h2o_p": -1.0, "h_p": 1.0, "inost_p": 1.0}, "id": "GPDDA5pp", "gene_reaction_rule": "ECs3124"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Geranyltranstransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GRTT"]}, "metabolites": {"ppi_c": 1.0, "ipdp_c": -1.0, "frdp_c": 1.0, "grdp_c": -1.0}, "id": "GRTT", "gene_reaction_rule": "ECs0475"}, {"subsystem": "Unassigned", "name": "Glutaredoxin reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GRXR"]}, "metabolites": {"grxox_c": -1.0, "gthrd_c": -2.0, "grxrd_c": 1.0, "gthox_c": 1.0}, "id": "GRXR", "gene_reaction_rule": "ECs1442 or ECs4488 or ECs2363 or ECs0929"}, {"subsystem": "Nucleotide Salvage 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"id": "GTPCII2", "gene_reaction_rule": "ECs1850"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Guanosine-5'-triphosphate,3'-diphosphate diphosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GTPDPDP"]}, "metabolites": {"ppgpp_c": 1.0, "gdptp_c": -1.0, "pi_c": 1.0, "h_c": 1.0, "h2o_c": -1.0}, "id": "GTPDPDP", "gene_reaction_rule": "ECs4712"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "GTP diphosphokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GTPDPK"]}, "metabolites": {"gdptp_c": 1.0, "gtp_c": -1.0, "amp_c": 1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "GTPDPK", "gene_reaction_rule": "ECs3644"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "GTP amine hydrolysis (spontaneous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GTPHs"]}, "metabolites": {"h2o_c": -1.0, "xtp_c": 1.0, "gtp_c": -1.0, "nh4_c": 1.0, "h_c": -1.0}, "id": "GTPHs", "gene_reaction_rule": "s0001"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "GTP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GTPtex"]}, "metabolites": {"gtp_e": -1.0, "gtp_p": 1.0}, "id": "GTPtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Guanylate cyclase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GUACYC"]}, "metabolites": {"ppi_c": 1.0, "gtp_c": -1.0, "35cgmp_c": 1.0}, "id": "GUACYC", "gene_reaction_rule": ""}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Guanine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GUAD"]}, "metabolites": {"xan_c": 1.0, "gua_c": -1.0, "h_c": -1.0, "h2o_c": -1.0, "nh4_c": 1.0}, "id": "GUAD", "gene_reaction_rule": "ECs3756"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Guanine phosphoribosyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GUAPRT"]}, "metabolites": {"gua_c": -1.0, "gmp_c": 1.0, "ppi_c": 1.0, "prpp_c": -1.0}, "id": "GUAPRT", "gene_reaction_rule": "ECs0265 or ECs0129"}, {"subsystem": "Transport, Inner Membrane", "name": "Guanine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GUAt2pp"]}, "metabolites": {"gua_p": -1.0, "gua_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GUAt2pp", "gene_reaction_rule": "ECs4530"}, {"subsystem": "Transport, Outer Membrane", "name": "Guanine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GUAtex"]}, "metabolites": {"gua_p": 1.0, "gua_e": -1.0}, "id": "GUAtex", "gene_reaction_rule": "ECs0464"}, {"subsystem": "Transport, Inner Membrane", "name": "Guanine transport via diffusion (periplasm)", "upper_bound": 1000.0, 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transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["H2tex"]}, "metabolites": {"h2_e": -1.0, "h2_p": 1.0}, "id": "H2tex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Inner Membrane", "name": "Hydrogen transport diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["H2tpp"]}, "metabolites": {"h2_c": 1.0, "h2_p": -1.0}, "id": "H2tpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HACD1"]}, "metabolites": {"aacoa_c": -1.0, "3hbcoa_c": 1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0}, "id": "HACD1", "gene_reaction_rule": "ECs4774 or ECs3224"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxohexanoyl-CoA)", 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"3-hydroxyacyl-CoA dehydrogenase (3-oxododecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HACD5"]}, "metabolites": {"3oddcoa_c": -1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "3hddcoa_c": 1.0}, "id": "HACD5", "gene_reaction_rule": "ECs4774 or ECs3224"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxotetradecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HACD6"]}, "metabolites": {"3otdcoa_c": -1.0, "3htdcoa_c": 1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0}, "id": "HACD6", "gene_reaction_rule": "ECs4774 or ECs3224"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxohexadecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HACD7"]}, "metabolites": {"nad_c": 1.0, "nadh_c": -1.0, "h_c": -1.0, "3ohdcoa_c": -1.0, "3hhdcoa_c": 1.0}, "id": "HACD7", "gene_reaction_rule": "ECs4774 or ECs3224"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxooctadecanoyl-CoA), peroxisomal", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HACD8"]}, "metabolites": {"3hodcoa_c": 1.0, "3oodcoa_c": -1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0}, "id": "HACD8", "gene_reaction_rule": "ECs4774 or ECs3224"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Hydroxybenzoate octaprenyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HBZOPT"]}, "metabolites": {"4hbz_c": -1.0, "3ophb_c": 1.0, "ppi_c": 1.0, "octdp_c": -1.0}, "id": "HBZOPT", "gene_reaction_rule": "ECs5023"}, {"subsystem": "Transport, Inner Membrane", "name": "3-hydroxycinnamic acid transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HCINNMt2rpp"]}, "metabolites": {"h_p": -1.0, "h_c": 1.0, "3hcinnm_p": -1.0, "3hcinnm_c": 1.0}, "id": "HCINNMt2rpp", "gene_reaction_rule": "ECs0408"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "3-hydroxycinnamic acid transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HCINNMtex"]}, "metabolites": {"3hcinnm_e": -1.0, "3hcinnm_p": 1.0}, "id": "HCINNMtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Unassigned", "name": "HCO3 equilibration reaction", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HCO3E"]}, "metabolites": {"hco3_c": 1.0, "h2o_c": -1.0, "co2_c": -1.0, "h_c": 1.0}, "id": "HCO3E", "gene_reaction_rule": "ECs0130 or ECs0392"}, {"subsystem": "Transport, Outer Membrane", "name": "Hexadecanoate transport via facilitated irreversible diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HDCAtexi"]}, "metabolites": {"hdca_e": -1.0, "hdca_p": 1.0}, "id": "HDCAtexi", "gene_reaction_rule": "ECs3227"}, {"subsystem": "Transport, Outer Membrane", "name": "Hexadecenoate transport via facilitated irreversible diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HDCEAtexi"]}, "metabolites": {"hdcea_p": 1.0, "hdcea_e": -1.0}, "id": "HDCEAtexi", "gene_reaction_rule": "ECs3227"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Heme O synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEMEOS"]}, "metabolites": {"h2o_c": -1.0, "hemeO_c": 1.0, "frdp_c": -1.0, "ppi_c": 1.0, "pheme_c": -1.0}, "id": "HEMEOS", "gene_reaction_rule": "ECs0482"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "LPS heptose kinase I (LPS core synthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEPK1"]}, "metabolites": {"hhlipa_c": -1.0, "phhlipa_c": 1.0, "atp_c": -1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "HEPK1", "gene_reaction_rule": "ECs4505"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Heptosyltransferase I (LPS core synthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEPT1"]}, "metabolites": {"hlipa_c": 1.0, "lipa_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "adphep_LD_c": -1.0}, "id": "HEPT1", "gene_reaction_rule": "ECs4499"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Heptosyltransferase II (LPS core synthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEPT2"]}, "metabolites": {"adp_c": 1.0, "hhlipa_c": 1.0, "h_c": 1.0, "adphep_LD_c": -1.0, "hlipa_c": -1.0}, "id": "HEPT2", "gene_reaction_rule": "ECs4498"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Heptosyltransferase III (LPS core synthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEPT3"]}, "metabolites": {"hphhlipa_c": 1.0, "phhlipa_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "adphep_LD_c": -1.0}, "id": "HEPT3", "gene_reaction_rule": "ECs4507"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Hydroxyethylthiazole kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HETZK"]}, "metabolites": {"4mhetz_c": -1.0, "4mpetz_c": 1.0, "atp_c": -1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "HETZK", "gene_reaction_rule": "ECs2907"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Hexokinase (D-glucose:ATP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEX1"]}, "metabolites": {"glc__D_c": -1.0, "g6p_c": 1.0, "atp_c": -1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "HEX1", "gene_reaction_rule": "ECs3268"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Hexokinase (D-mannose:ATP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEX4"]}, "metabolites": {"adp_c": 1.0, "man6p_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "man_c": -1.0}, "id": "HEX4", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Hexokinase (D-fructose:ATP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HEX7"]}, "metabolites": {"adp_c": 1.0, "fru_c": -1.0, "h_c": 1.0, "atp_c": -1.0, "f6p_c": 1.0}, "id": "HEX7", "gene_reaction_rule": "ECs0444"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Mercury (Hg+2) ABC transporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HG2abcpp"]}, "metabolites": {"h2o_c": -1.0, "hg2_p": 1.0, "atp_c": -1.0, "hg2_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "HG2abcpp", "gene_reaction_rule": "ECs4318"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Mercury (Hg+2) transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HG2t3pp"]}, "metabolites": {"hg2_c": -1.0, "hg2_p": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "HG2t3pp", "gene_reaction_rule": "ECs4840"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Mercury (Hg+2) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HG2tex"]}, "metabolites": {"hg2_p": 1.0, "hg2_e": -1.0}, "id": "HG2tex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Histidine Metabolism", "name": "Histidinol dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HISTD"]}, "metabolites": {"histd_c": -1.0, "h2o_c": -1.0, "his__L_c": 1.0, "h_c": 3.0, "nad_c": -2.0, "nadh_c": 2.0}, "id": "HISTD", "gene_reaction_rule": "ECs2821"}, {"subsystem": "Histidine Metabolism", "name": "Histidinol-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HISTP"]}, "metabolites": {"hisp_c": -1.0, "histd_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0}, "id": "HISTP", "gene_reaction_rule": "ECs2823"}, {"subsystem": "tRNA Charging", "name": "Histidyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HISTRS"]}, "metabolites": {"histrna_c": 1.0, "atp_c": -1.0, "his__L_c": -1.0, "ppi_c": 1.0, "trnahis_c": -1.0, "amp_c": 1.0}, "id": "HISTRS", "gene_reaction_rule": "ECs3376"}, {"subsystem": "Transport, Inner Membrane", "name": "L-histidine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HISabcpp"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "atp_c": -1.0, "his__L_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "his__L_p": -1.0}, "id": "HISabcpp", "gene_reaction_rule": "ECs3193 and ECs3191 and ECs3190 and ECs3192"}, {"subsystem": "Transport, Inner Membrane", "name": "L-histidine reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HISt2rpp"]}, "metabolites": {"his__L_c": 1.0, "his__L_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "HISt2rpp", "gene_reaction_rule": "ECs0116"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-histidine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HIStex"]}, "metabolites": {"his__L_p": 1.0, "his__L_e": -1.0}, "id": "HIStex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HKNDDH"]}, "metabolites": {"h_c": 1.0, "hkndd_c": -1.0, "succ_c": 1.0, "h2o_c": -1.0, "op4en_c": 1.0}, "id": "HKNDDH", "gene_reaction_rule": "ECs0404"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-hydroxy-6-ketononotrienedioate hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HKNTDH"]}, "metabolites": {"h_c": 1.0, "h2o_c": -1.0, "fum_c": 1.0, "hkntd_c": -1.0, "op4en_c": 1.0}, "id": "HKNTDH", "gene_reaction_rule": "ECs0404"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Hydroxymethylbilane synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HMBS"]}, "metabolites": {"ppbng_c": -4.0, "h2o_c": -1.0, "hmbil_c": 1.0, "nh4_c": 4.0}, "id": "HMBS", "gene_reaction_rule": "ECs4735"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Hydroxymethylpyrimidine kinase (ATP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HMPK1"]}, "metabolites": {"h_c": 1.0, "4ampm_c": 1.0, "4ahmmp_c": -1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "HMPK1", "gene_reaction_rule": "ECs2906 or ECs3290"}, {"subsystem": "Transport, Inner Membrane", "name": "L-homoserineserine efflux via proton symport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HOMt2pp"]}, "metabolites": {"hom__L_c": -1.0, "hom__L_p": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "HOMt2pp", "gene_reaction_rule": "ECs0891 or ECs4754"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-homoserine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HOMtex"]}, "metabolites": {"hom__L_p": 1.0, "hom__L_e": -1.0}, "id": "HOMtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Alternate Carbon Metabolism", "name": "4-hydroxy-2-oxopentanoate aldolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HOPNTAL"]}, "metabolites": {"acald_c": 1.0, "pyr_c": 1.0, "4h2opntn_c": -1.0}, "id": "HOPNTAL", "gene_reaction_rule": "ECs0407"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "6-hydroxymethyl-dihydropterin pyrophosphokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HPPK2"]}, "metabolites": {"6hmhptpp_c": 1.0, "6hmhpt_c": -1.0, "amp_c": 1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "HPPK2", "gene_reaction_rule": "ECs0146"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2,3-dihydroxypheylpropionate 1,2-dioxygenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HPPPNDO"]}, "metabolites": {"dhpppn_c": -1.0, "o2_c": -1.0, "hkndd_c": 1.0, "h_c": 1.0}, "id": "HPPPNDO", "gene_reaction_rule": "ECs0403"}, {"subsystem": "Transport, Inner Membrane", "name": "3-(3-hydroxyphenyl)propionate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HPPPNt2rpp"]}, "metabolites": {"3hpppn_p": -1.0, "h_c": 1.0, "h_p": -1.0, "3hpppn_c": 1.0}, "id": "HPPPNt2rpp", "gene_reaction_rule": "ECs0408"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "3-(3-hydroxyphenyl)propionate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HPPPNtex"]}, "metabolites": {"3hpppn_e": -1.0, "3hpppn_p": 1.0}, "id": "HPPPNtex", "gene_reaction_rule": "ECs1012 or ompN or ECs3104 or ECs0268"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Hydroxypyruvate isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["HPYRI"]}, "metabolites": {"hpyr_c": -1.0, "2h3oppan_c": 1.0}, "id": "HPYRI", "gene_reaction_rule": "ECs0569"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Hydroxypyruvate reductase (NADH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HPYRRx"]}, "metabolites": {"hpyr_c": -1.0, "nadh_c": -1.0, "glyc__R_c": 1.0, "h_c": -1.0, "nad_c": 1.0}, "id": "HPYRRx", "gene_reaction_rule": "ECs1410 or ECs4438"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Hydroxypyruvate reductase (NADPH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HPYRRy"]}, "metabolites": {"hpyr_c": -1.0, "nadp_c": 1.0, 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"h_c": 6.0, "fad_c": 1.0}, "id": "I2FE2SS2", "gene_reaction_rule": "ECs4738 and ECs3396 and ECs3395"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "ISC [2Fe-2S] Transfer", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["I2FE2ST"]}, "metabolites": {"2fe2s_c": 1.0, "iscu_c": 1.0, "h_c": -4.0, "iscu_2fe2s_c": -1.0}, "id": "I2FE2ST", "gene_reaction_rule": "ECs3394 and ECs3395"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "ISC [4Fe-4S] Reduction", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["I4FE4SR"]}, "metabolites": {"fad_c": 1.0, "fadh2_c": -1.0, "iscu_4fe4s_c": 1.0, "h_c": -2.0, "iscu_2fe2s2_c": -1.0}, "id": "I4FE4SR", "gene_reaction_rule": "ECs3395"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "ISC [4Fe-4S] Transfer", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["I4FE4ST"]}, "metabolites": {"iscu_4fe4s_c": -1.0, "iscu_c": 1.0, "4fe4s_c": 1.0, "h_c": -4.0}, "id": "I4FE4ST", "gene_reaction_rule": "ECs3394 and ECs3395"}, {"subsystem": "Citric Acid Cycle", "name": "Isocitrate dehydrogenase (NADP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ICDHyr"]}, "metabolites": {"akg_c": 1.0, "co2_c": 1.0, "icit_c": -1.0, "nadph_c": 1.0, "nadp_c": -1.0}, "id": "ICDHyr", "gene_reaction_rule": "ECs1608"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Isochorismate synthase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ICHORS", "ICHORSi"]}, "metabolites": {"chor_c": -1.0, "ichor_c": 1.0}, "id": "ICHORS_copy1", "gene_reaction_rule": "ECs3153"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Isochorismate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ICHORS", "ICHORSi"]}, "metabolites": {"chor_c": -1.0, "ichor_c": 1.0}, "id": "ICHORS_copy2", "gene_reaction_rule": "ECs0632"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Isochorismatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ICHORT"]}, "metabolites": {"pyr_c": 1.0, "ichor_c": -1.0, "h2o_c": -1.0, "23ddhb_c": 1.0}, "id": "ICHORT", "gene_reaction_rule": "ECs0634"}, {"subsystem": "Anaplerotic Reactions", "name": "Isocitrate lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ICL"]}, "metabolites": {"succ_c": 1.0, "icit_c": -1.0, "glx_c": 1.0}, "id": "ICL", "gene_reaction_rule": "ECs4933"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "ISC Cysteine desulfuration", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ICYSDS"]}, "metabolites": {"cys__L_c": -1.0, "ala__L_c": 1.0, "iscssh_c": 1.0, "iscs_c": -1.0}, "id": "ICYSDS", "gene_reaction_rule": "ECs3396"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-idonate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IDONtex"]}, "metabolites": {"idon__L_p": 1.0, "idon__L_e": -1.0}, "id": "IDONtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Histidine Metabolism", "name": "Imidazole-glycerol-3-phosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IG3PS"]}, "metabolites": {"aicar_c": 1.0, "glu__L_c": 1.0, "eig3p_c": 1.0, "h_c": 1.0, "prlp_c": -1.0, "gln__L_c": -1.0}, "id": "IG3PS", "gene_reaction_rule": "ECs2824 and ECs2826"}, {"subsystem": "Histidine Metabolism", "name": "Imidazoleglycerol-phosphate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IGPDH"]}, "metabolites": {"h2o_c": 1.0, "imacp_c": 1.0, "eig3p_c": -1.0}, "id": "IGPDH", "gene_reaction_rule": "ECs2823"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Indole-3-glycerol-phosphate 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and Pyrimidine Biosynthesis", "name": "IMP cyclohydrolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IMPC"]}, "metabolites": {"h2o_c": -1.0, "fprica_c": 1.0, "imp_c": -1.0}, "id": "IMPC", "gene_reaction_rule": "ECs4929"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "IMP dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IMPD"]}, "metabolites": {"xmp_c": 1.0, "h2o_c": -1.0, "h_c": 1.0, "nad_c": -1.0, "nadh_c": 1.0, "imp_c": -1.0}, "id": "IMPD", "gene_reaction_rule": "ECs3370"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "IMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IMPtex"]}, "metabolites": {"imp_e": -1.0, "imp_p": 1.0}, "id": "IMPtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Inner Membrane", "name": "Indole transport via proton symport, 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1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["INSTtex"]}, "metabolites": {"inost_e": -1.0, "inost_p": 1.0}, "id": "INSTtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Inner Membrane", "name": "Inosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["INSt2pp"]}, "metabolites": {"ins_p": -1.0, "h_c": 1.0, "h_p": -1.0, "ins_c": 1.0}, "id": "INSt2pp", "gene_reaction_rule": "ECs3840"}, {"subsystem": "Transport, Outer Membrane", "name": "Inosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["INStex"]}, "metabolites": {"ins_e": -1.0, "ins_p": 1.0}, "id": "INStex", "gene_reaction_rule": "ECs0464"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Isopentenyl-diphosphate D-isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": 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{"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "KDO(2)-lipid IV A transport via ABC system (periplasm to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["K2L4Aabctex"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "kdo2lipid4_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "kdo2lipid4_e": 1.0}, "id": "K2L4Aabctex", "gene_reaction_rule": "ECs4079 and ECs4080 and ECs4078 and ECs5238 and ECs5239"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Ketol-acid reductoisomerase (2,3-dihydroxy-3-methylbutanoate)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["KARA1"]}, "metabolites": {"nadp_c": -1.0, "nadph_c": 1.0, "h_c": 1.0, "23dhmb_c": -1.0, "alac__S_c": 1.0}, "id": "KARA1", "gene_reaction_rule": "ECs4708"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Ketol-acid reductoisomerase (2-Acetolactate)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["KARA2"]}, "metabolites": {"23dhmp_c": 1.0, "2ahbut_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0}, "id": "KARA2", "gene_reaction_rule": "ECs4708"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Beta-ketoacyl-ACP synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KAS14"]}, "metabolites": {"acACP_c": -1.0, "ACP_c": 1.0, "malACP_c": -1.0, "h_c": -1.0, "actACP_c": 1.0, "co2_c": 1.0}, "id": "KAS14", "gene_reaction_rule": "ECs3207 or ECs1473"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Beta-ketoacyl-ACP synthase (2)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KAS15"]}, "metabolites": {"malACP_c": -1.0, "coa_c": 1.0, "h_c": -1.0, "accoa_c": -1.0, "actACP_c": 1.0, "co2_c": 1.0}, "id": "KAS15", "gene_reaction_rule": "ECs1469"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "3-deoxy-manno-octulosonate cytidylyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KDOCT2"]}, "metabolites": {"ctp_c": -1.0, "ckdo_c": 1.0, "ppi_c": 1.0, "kdo_c": -1.0}, "id": "KDOCT2", "gene_reaction_rule": "ECs1001"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "3-deoxy-manno-octulosonate-8-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KDOPP"]}, "metabolites": {"kdo_c": 1.0, "kdo8p_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0}, "id": "KDOPP", "gene_reaction_rule": "ECs4077"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "3-deoxy -D-manno-octulosonic -acid 8-phosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KDOPS"]}, "metabolites": {"pep_c": -1.0, "kdo8p_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0, "ara5p_c": -1.0}, "id": "KDOPS", "gene_reaction_rule": "ECs1720"}, {"subsystem": "Alternate Carbon Metabolism", "name": "3-keto-L-gulonate 6-phosphate decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KG6PDC"]}, "metabolites": {"3dhgulnp_c": -1.0, "xu5p__L_c": 1.0, "co2_c": 1.0, "h_c": -1.0}, "id": "KG6PDC", "gene_reaction_rule": "ECs5172"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Potassium ABC transporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["Kabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "k_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "k_c": 1.0, "pi_c": 1.0}, "id": "Kabcpp", "gene_reaction_rule": "ECs0726 and ECs0725 and ECs0724"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Potassium transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["Kt2pp"]}, "metabolites": {"k_p": -1.0, "k_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "Kt2pp", "gene_reaction_rule": "(ECs1868 and ECs4155 and ECs4777) or ECs1750 or ECs4689"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Potassium transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["Kt3pp"]}, "metabolites": {"k_p": 1.0, "k_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "Kt3pp", "gene_reaction_rule": "ECs1721 or ECs0922 or ECs4201 or ECs0050"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Potassium transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["Ktex"]}, "metabolites": {"k_p": 1.0, "k_e": -1.0}, "id": "Ktex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Oxidative Phosphorylation", "name": "L-Lactate dehydrogenase (ubiquinone)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["L_DASH_LACD2"]}, "metabolites": {"q8h2_c": 1.0, "pyr_c": 1.0, "lac__L_c": -1.0, "q8_c": -1.0}, "id": "L_LACD2", "gene_reaction_rule": "ECs4483 or (ECs0344 and ECs0345 and ECs0346)"}, {"subsystem": "Oxidative Phosphorylation", "name": "L-Lactate dehydrogenase (menaquinone)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["L_DASH_LACD3"]}, "metabolites": {"lac__L_c": -1.0, "pyr_c": 1.0, "mqn8_c": -1.0, "mql8_c": 1.0}, "id": "L_LACD3", "gene_reaction_rule": "ECs4483 or (ECs0344 and ECs0345 and ECs0346)"}, {"subsystem": "Transport, Inner Membrane", "name": "L-lactate reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["L_DASH_LACt2rpp"]}, "metabolites": {"lac__L_c": 1.0, "h_c": 1.0, "h_p": -1.0, "lac__L_p": -1.0}, "id": "L_LACt2rpp", "gene_reaction_rule": "ECs4481"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-lactate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["L_DASH_LACtex"]}, "metabolites": {"lac__L_e": -1.0, "lac__L_p": 1.0}, "id": "L_LACtex", "gene_reaction_rule": "ECs1012 or ompN or ECs3104 or ECs0268"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "4-amino-4-deoxy-L-arabinotransferase (LPS lipid A modification, periplasmic face of membrane))", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LA4NTpp"]}, "metabolites": {"acolipa_p": 1.0, "colipa_p": -1.0, "uLa4n_p": -1.0, "udcpp_p": 1.0}, "id": "LA4NTpp", "gene_reaction_rule": "ECs3145"}, {"subsystem": "Alternate Carbon Metabolism", "name": "B-galactosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LACZ"]}, "metabolites": {"lcts_c": -1.0, "glc__D_c": 1.0, "h2o_c": -1.0, "gal_c": 1.0}, "id": "LACZ", "gene_reaction_rule": "ECs0397"}, {"subsystem": "Alternate Carbon Metabolism", "name": "B-galactosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LACZpp"]}, "metabolites": {"gal_p": 1.0, "h2o_p": -1.0, "lcts_p": -1.0, "glc__D_p": 1.0}, "id": "LACZpp", "gene_reaction_rule": "ECs3019"}, {"subsystem": "Murein Recycling", "name": "L-alanyl-gamma-D-glutamyl-meso-diaminopimelate hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LADGMDH"]}, "metabolites": {"LalaDglu_c": 1.0, "26dap__M_c": 1.0, "h2o_c": -1.0, "LalaDgluMdap_c": -1.0}, "id": "LADGMDH", "gene_reaction_rule": "ECs1905"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-alanyl-D-glutamate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LALADGLUtex"]}, "metabolites": {"LalaDglu_p": 1.0, "LalaDglu_e": -1.0}, "id": "LALADGLUtex", "gene_reaction_rule": "ECs3104 or ompN or ECs0268 or ECs1012"}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanyl-D-glutamate transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LALADGLUtpp"]}, "metabolites": {"LalaDglu_p": -1.0, "LalaDglu_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "LALADGLUtpp", "gene_reaction_rule": "ECs2343 or ECs4368 or ECs5112 or ECs0734"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-alanyl-L-glutamate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LALALGLUtex"]}, "metabolites": {"LalaLglu_p": 1.0, "LalaLglu_e": -1.0}, "id": "LALALGLUtex", "gene_reaction_rule": "ECs3104 or ompN or ECs0268 or ECs1012"}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanyl-L-glutamate transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LALALGLUtpp"]}, "metabolites": {"LalaLglu_p": -1.0, "LalaLglu_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "LALALGLUtpp", "gene_reaction_rule": "ECs2343 or ECs4368 or ECs5112 or ECs0734"}, {"subsystem": "Methylglyoxal Metabolism", "name": "D-Lactaldehyde:NAD+ 1-oxidoreductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LALDO2x"]}, "metabolites": {"nad_c": 1.0, "nadh_c": -1.0, "mthgxl_c": -1.0, "lald__D_c": 1.0, "h_c": -1.0}, "id": "LALDO2x", "gene_reaction_rule": "ECs4874"}, {"subsystem": "Methylglyoxal Metabolism", "name": "L-Lactaldehyde:NADP+ 1-oxidoreductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LALDO3"]}, "metabolites": {"nadph_c": -1.0, "mthgxl_c": -1.0, "nadp_c": 1.0, "h_c": -1.0, "lald__L_c": 1.0}, "id": "LALDO3", "gene_reaction_rule": ""}, {"subsystem": "Murein Recycling", "name": "L-alanyl-gamma-L-glutamate peptidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LALGP"]}, "metabolites": {"glu__L_c": 1.0, "ala__L_c": 1.0, "LalaLglu_c": -1.0, "h2o_c": -1.0}, "id": "LALGP", "gene_reaction_rule": "ECs0264"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Lactaldehyde dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LCADi"]}, "metabolites": {"h2o_c": -1.0, "lald__L_c": -1.0, "lac__L_c": 1.0, "h_c": 2.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "LCADi", "gene_reaction_rule": "ECs2021"}, {"subsystem": "Methylglyoxal Metabolism", "name": "Lacaldehyde reductase (R-propane-1,2-diol forming)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LCARR"]}, "metabolites": {"lald__D_c": -1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "12ppd__R_c": 1.0}, "id": "LCARR", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Lacaldehyde reductase (S-propane-1,2-diol forming)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LCARS"]}, "metabolites": {"12ppd__S_c": 1.0, "nad_c": 1.0, "nadh_c": -1.0, "h_c": -1.0, "lald__L_c": -1.0}, "id": "LCARS", "gene_reaction_rule": "ECs3659"}, {"subsystem": "Transport, Inner Membrane", "name": "Lactose transport via proton aniport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LCTSt3ipp"]}, "metabolites": {"lcts_c": -1.0, "lcts_p": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "LCTSt3ipp", "gene_reaction_rule": "ECs3062 or ECs2135"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Lactose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LCTStex"]}, "metabolites": {"lcts_p": 1.0, "lcts_e": -1.0}, "id": "LCTStex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Inner Membrane", "name": "Lactose transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LCTStpp"]}, "metabolites": {"lcts_c": 1.0, "lcts_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "LCTStpp", "gene_reaction_rule": "ECs0396"}, {"subsystem": "Pyruvate Metabolism", "name": "D-lactate dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LDH_D"]}, "metabolites": {"pyr_c": 1.0, "nadh_c": 1.0, "lac__D_c": -1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "LDH_D", "gene_reaction_rule": "ECs3020 or ECs2002"}, {"subsystem": "Oxidative Phosphorylation", "name": "D-lactate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LDH_D2"]}, "metabolites": {"q8h2_c": 1.0, "pyr_c": 1.0, "lac__D_c": -1.0, "q8_c": -1.0}, "id": "LDH_D2", "gene_reaction_rule": "ECs3020"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Leucine transaminase (irreversible)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LEUTAi"]}, "metabolites": {"akg_c": 1.0, "leu__L_c": 1.0, "4mop_c": -1.0, "glu__L_c": -1.0}, "id": "LEUTAi", "gene_reaction_rule": "ECs4704 or ECs5036"}, {"subsystem": "tRNA Charging", "name": "Leucyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LEUTRS"]}, "metabolites": {"leutrna_c": 1.0, "leu__L_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "trnaleu_c": -1.0}, "id": "LEUTRS", "gene_reaction_rule": "ECs0680"}, {"subsystem": "Transport, Inner Membrane", "name": "L-leucine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LEUabcpp"]}, "metabolites": {"leu__L_c": 1.0, "atp_c": -1.0, "h2o_c": -1.0, "leu__L_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "LEUabcpp", "gene_reaction_rule": "(ECs4301 and ECs4302 and ECs4304 and ECs4309 and ECs4303) or (ECs4301 and ECs4302 and ECs4304 and ECs4305 and ECs4303)"}, {"subsystem": "Transport, Inner Membrane", "name": "L-leucine reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LEUt2rpp"]}, "metabolites": {"leu__L_p": -1.0, "leu__L_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "LEUt2rpp", "gene_reaction_rule": "ECs0451"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-leucine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LEUtex"]}, "metabolites": {"leu__L_p": 1.0, "leu__L_e": -1.0}, "id": "LEUtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Methylglyoxal Metabolism", "name": "Lactoylglutathione lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LGTHL"]}, "metabolites": {"gthrd_c": -1.0, "lgt__S_c": 1.0, "mthgxl_c": -1.0}, "id": "LGTHL", "gene_reaction_rule": "ECs2360"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Lipid (cold) A transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPACabcpp"]}, "metabolites": {"h2o_c": -1.0, "lipa_cold_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "lipa_cold_p": 1.0, "pi_c": 1.0}, "id": "LIPACabcpp", "gene_reaction_rule": "ECs0997"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Core oligosaccharide lipid A:hexadecanoate transferase (n-C16:0) (extracellular membrane)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPAHT2ex"]}, "metabolites": {"hdca_e": -1.0, "h_e": -1.0, "h2o_e": 1.0, "hacolipa_e": 1.0, "colipa_e": -1.0}, "id": "LIPAHT2ex", "gene_reaction_rule": "ECs0661"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Lipid A:hexadecanoate transferase (n-C16:0) (extracellular membrane)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPAHTex"]}, "metabolites": {"lipa_e": -1.0, "hdca_e": -1.0, "h_e": -1.0, "h2o_e": 1.0, "halipa_e": 1.0}, "id": "LIPAHTex", "gene_reaction_rule": "ECs0661"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Lipoyl-adenylate protein ligase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPAMPL"]}, "metabolites": {"amp_c": 1.0, "lipopb_c": 1.0, "lipoamp_c": -1.0}, "id": "LIPAMPL", "gene_reaction_rule": "ECs5345"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Lipoate-ATP adenylate transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPATPT"]}, "metabolites": {"ppi_c": 1.0, "lipoate_c": -1.0, "atp_c": -1.0, "lipoamp_c": 1.0}, "id": "LIPATPT", "gene_reaction_rule": "ECs5345"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Lipid A transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPAabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "lipa_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "lipa_c": -1.0}, "id": "LIPAabcpp", "gene_reaction_rule": "ECs0997"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Lipid A transport via ABC system (periplasm to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPAabctex"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "lipa_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "lipa_e": 1.0, "pi_c": 1.0}, "id": "LIPAabctex", "gene_reaction_rule": "ECs4079 and ECs4080 and ECs4078 and ECs5238 and ECs5239"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Lipoyl(octanoyl) transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPOCT"]}, "metabolites": {"octapb_c": 1.0, "ocACP_c": -1.0, "ACP_c": 1.0, "h_c": -1.0}, "id": "LIPOCT", "gene_reaction_rule": "ECs0668"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Lipoate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPOS"]}, "metabolites": {"nad_c": -1.0, "fe2_c": 2.0, "dad_5_c": 2.0, "2fe2s_c": 1.0, "4fe4s_c": -1.0, "h_c": -1.0, "met__L_c": 2.0, "amet_c": -2.0, "nadh_c": 1.0, "lipopb_c": 1.0, "octapb_c": -1.0}, "id": "LIPOS", "gene_reaction_rule": "ECs0666"}, {"subsystem": "Transport, Inner Membrane", "name": "Lipoate transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPOt2pp"]}, "metabolites": {"lipoate_p": -1.0, "lipoate_c": 1.0, "h_p": -1.0, "h_c": 1.0}, "id": "LIPOt2pp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Lipoate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LIPOtex"]}, "metabolites": {"lipoate_e": -1.0, "lipoate_p": 1.0}, "id": "LIPOtex", "gene_reaction_rule": "ompN or ECs3104 or ECs1012 or ECs0268"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Lipid A disaccaride synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPADSS"]}, "metabolites": {"u23ga_c": -1.0, "udp_c": 1.0, "h_c": 1.0, "lipidAds_c": 1.0, "lipidX_c": -1.0}, "id": "LPADSS", "gene_reaction_rule": "ECs0184"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphotidate, n-C12:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1A120pp"]}, "metabolites": {"glyc3p_p": 1.0, "1ddecg3p_p": -1.0, "ddca_p": 1.0, "h_p": 1.0, "h2o_p": -1.0}, "id": "LPLIPAL1A120pp", "gene_reaction_rule": "ECs0558"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphotidate, n-C14:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1A140pp"]}, "metabolites": {"h2o_p": -1.0, "1tdecg3p_p": -1.0, "h_p": 1.0, "ttdca_p": 1.0, "glyc3p_p": 1.0}, "id": "LPLIPAL1A140pp", "gene_reaction_rule": "ECs0558"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphotidate, n-C14:1) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1A141pp"]}, "metabolites": {"h2o_p": -1.0, "ttdcea_p": 1.0, "1tdec7eg3p_p": -1.0, "h_p": 1.0, "glyc3p_p": 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"Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphoethanolamine, n-C14:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1E140pp"]}, "metabolites": {"ttdca_p": 1.0, "h2o_p": -1.0, "g3pe_p": 1.0, "1agpe140_p": -1.0, "h_p": 1.0}, "id": "LPLIPAL1E140pp", "gene_reaction_rule": "ECs0558"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphoethanolamine, n-C14:1) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1E141pp"]}, "metabolites": {"h2o_p": -1.0, "ttdcea_p": 1.0, "g3pe_p": 1.0, "h_p": 1.0, "1agpe141_p": -1.0}, "id": "LPLIPAL1E141pp", "gene_reaction_rule": "ECs0558"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphoethanolamine, n-C16:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1E160pp"]}, "metabolites": 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(2-acylglycerophosphoethanolamine, n-C18:1) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1E181pp"]}, "metabolites": {"h2o_p": -1.0, "ocdcea_p": 1.0, "1agpe181_p": -1.0, "g3pe_p": 1.0, "h_p": 1.0}, "id": "LPLIPAL1E181pp", "gene_reaction_rule": "ECs0558"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphoglycerol, n-C12:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1G120pp"]}, "metabolites": {"h2o_p": -1.0, "g3pg_p": 1.0, "ddca_p": 1.0, "h_p": 1.0, "1agpg120_p": -1.0}, "id": "LPLIPAL1G120pp", "gene_reaction_rule": "ECs0558"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L1 (2-acylglycerophosphoglycerol, n-C14:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL1G140pp"]}, "metabolites": {"h2o_p": -1.0, "g3pg_p": 1.0, "1agpg140_p": -1.0, "ttdca_p": 1.0, 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(acyltransferase, 2-acyl-glycerophosphoethanolamine, n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATE140"]}, "metabolites": {"pg140_c": -1.0, "2agpe140_c": -1.0, "apg140_c": 1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2ATE140", "gene_reaction_rule": "ECs4755"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoethanolamine, n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATE141"]}, "metabolites": {"pg141_c": -1.0, "apg141_c": 1.0, "2agpe141_c": -1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2ATE141", "gene_reaction_rule": "ECs4755"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoethanolamine, n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATE160"]}, "metabolites": {"pg160_c": -1.0, "apg160_c": 1.0, "2agpe160_c": -1.0, "g3pe_c": 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"Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATG141"]}, "metabolites": {"pg141_c": -1.0, "g3pg_c": 1.0, "2agpg141_c": -1.0, "apg141_c": 1.0}, "id": "LPLIPAL2ATG141", "gene_reaction_rule": "ECs4755"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATG160"]}, "metabolites": {"pg160_c": -1.0, "g3pg_c": 1.0, "2agpg160_c": -1.0, "apg160_c": 1.0}, "id": "LPLIPAL2ATG160", "gene_reaction_rule": "ECs4755"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATG161"]}, "metabolites": {"g3pg_c": 1.0, "pg161_c": -1.0, "apg161_c": 1.0, "2agpg161_c": -1.0}, "id": "LPLIPAL2ATG161", "gene_reaction_rule": "ECs4755"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATG180"]}, "metabolites": {"g3pg_c": 1.0, "pg180_c": -1.0, "2agpg180_c": -1.0, "apg180_c": 1.0}, "id": "LPLIPAL2ATG180", "gene_reaction_rule": "ECs4755"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (acyltransferase, 2-acyl-glycerophosphoglycerol, n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2ATG181"]}, "metabolites": {"apg181_c": 1.0, "g3pg_c": 1.0, "pg181_c": -1.0, "2agpg181_c": -1.0}, "id": "LPLIPAL2ATG181", "gene_reaction_rule": "ECs4755"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E120"]}, "metabolites": {"ddca_c": 1.0, "2agpe120_c": -1.0, "h2o_c": -1.0, "h_c": 1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2E120", "gene_reaction_rule": "ECs4755"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E140"]}, "metabolites": {"h2o_c": -1.0, "ttdca_c": 1.0, "2agpe140_c": -1.0, "h_c": 1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2E140", "gene_reaction_rule": "ECs4755"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E141"]}, "metabolites": {"2agpe141_c": -1.0, "h2o_c": -1.0, "g3pe_c": 1.0, "h_c": 1.0, "ttdcea_c": 1.0}, "id": "LPLIPAL2E141", "gene_reaction_rule": "ECs4755"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E160"]}, "metabolites": {"h2o_c": -1.0, "hdca_c": 1.0, "h_c": 1.0, "2agpe160_c": -1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2E160", "gene_reaction_rule": "ECs4755"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E161"]}, "metabolites": {"hdcea_c": 1.0, "h2o_c": -1.0, "2agpe161_c": -1.0, "h_c": 1.0, "g3pe_c": 1.0}, "id": "LPLIPAL2E161", "gene_reaction_rule": "ECs4755"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E180"]}, "metabolites": {"2agpe180_c": -1.0, "h2o_c": -1.0, "g3pe_c": 1.0, "h_c": 1.0, "ocdca_c": 1.0}, "id": "LPLIPAL2E180", "gene_reaction_rule": "ECs4755"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoethanolamine, n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2E181"]}, "metabolites": {"2agpe181_c": -1.0, "h2o_c": -1.0, "g3pe_c": 1.0, "h_c": 1.0, "ocdcea_c": 1.0}, "id": "LPLIPAL2E181", "gene_reaction_rule": "ECs4755"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G120"]}, "metabolites": {"ddca_c": 1.0, "g3pg_c": 1.0, "h2o_c": -1.0, "2agpg120_c": -1.0, "h_c": 1.0}, "id": "LPLIPAL2G120", "gene_reaction_rule": "ECs4755"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G140"]}, "metabolites": {"g3pg_c": 1.0, "h2o_c": -1.0, "h_c": 1.0, "2agpg140_c": -1.0, "ttdca_c": 1.0}, "id": "LPLIPAL2G140", "gene_reaction_rule": "ECs4755"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G141"]}, "metabolites": {"g3pg_c": 1.0, "h2o_c": -1.0, "2agpg141_c": -1.0, "h_c": 1.0, "ttdcea_c": 1.0}, "id": "LPLIPAL2G141", "gene_reaction_rule": "ECs4755"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G160"]}, "metabolites": {"2agpg160_c": -1.0, "g3pg_c": 1.0, "h2o_c": -1.0, "hdca_c": 1.0, "h_c": 1.0}, "id": "LPLIPAL2G160", "gene_reaction_rule": "ECs4755"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G161"]}, "metabolites": {"hdcea_c": 1.0, "g3pg_c": 1.0, "h2o_c": -1.0, "h_c": 1.0, "2agpg161_c": -1.0}, "id": "LPLIPAL2G161", "gene_reaction_rule": "ECs4755"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G180"]}, "metabolites": {"g3pg_c": 1.0, "h2o_c": -1.0, "h_c": 1.0, "2agpg180_c": -1.0, "ocdca_c": 1.0}, "id": "LPLIPAL2G180", "gene_reaction_rule": "ECs4755"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G181"]}, "metabolites": {"ocdcea_c": 1.0, "h2o_c": -1.0, "g3pg_c": 1.0, "h_c": 1.0, "2agpg181_c": -1.0}, "id": "LPLIPAL2G181", "gene_reaction_rule": "ECs4755"}, {"subsystem": "Glycine and Serine Metabolism", "name": "L-serine dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LSERDHr"]}, "metabolites": {"2amsa_c": 1.0, "ser__L_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "h_c": 1.0}, "id": "LSERDHr", "gene_reaction_rule": "ECs2148"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Lysine decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSDC"]}, "metabolites": {"15dap_c": 1.0, "co2_c": 1.0, "lys__L_c": -1.0, "h_c": -1.0}, "id": "LYSDC", "gene_reaction_rule": "ECs0188"}, {"subsystem": "tRNA Charging", "name": "Lysyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSTRS"]}, "metabolites": {"trnalys_c": -1.0, "lys__L_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "lystrna_c": 1.0}, "id": "LYSTRS", "gene_reaction_rule": "ECs3762"}, {"subsystem": "Transport, Inner Membrane", "name": "L-lysine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSabcpp"]}, "metabolites": {"h2o_c": -1.0, "lys__L_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "lys__L_p": -1.0, "pi_c": 1.0}, "id": "LYSabcpp", "gene_reaction_rule": "ECs3194 and ECs3191 and ECs3190 and ECs3192"}, {"subsystem": "Transport, Inner Membrane", "name": "L-lysine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSt2pp"]}, "metabolites": {"lys__L_c": 1.0, "h_c": 1.0, "h_p": -1.0, "lys__L_p": -1.0}, "id": "LYSt2pp", "gene_reaction_rule": "ECs3048"}, {"subsystem": "Transport, Inner Membrane", "name": "L-lysine transport out via proton antiport (cytoplasm to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSt3pp"]}, "metabolites": {"lys__L_c": -1.0, "h_c": 1.0, "h_p": -1.0, "lys__L_p": 1.0}, "id": "LYSt3pp", "gene_reaction_rule": "ECs3794"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-lysine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LYStex"]}, "metabolites": {"lys__L_e": -1.0, "lys__L_p": 1.0}, "id": "LYStex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Lyxose isomerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYXI"]}, "metabolites": {"xylu__L_c": 1.0, "lyx__L_c": -1.0}, "id": "LYXI", "gene_reaction_rule": "ECs4830"}, {"subsystem": "Transport, Inner Membrane", "name": "L-Lyxose transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYXt2pp"]}, "metabolites": {"h_c": 1.0, "lyx__L_p": -1.0, "h_p": -1.0, "lyx__L_c": 1.0}, "id": "LYXt2pp", "gene_reaction_rule": "rhaT"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-Lyxose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LYXtex"]}, "metabolites": {"lyx__L_e": -1.0, "lyx__L_p": 1.0}, "id": "LYXtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Mannitol-1-phosphate 5-dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["M1PD"]}, "metabolites": {"nad_c": -1.0, "f6p_c": 1.0, "h_c": 1.0, "nadh_c": 1.0, "mnl1p_c": -1.0}, "id": "M1PD", "gene_reaction_rule": "ECs4476"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Malonyl-ACP decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MACPD"]}, "metabolites": {"acACP_c": 1.0, "co2_c": 1.0, "malACP_c": -1.0, "h_c": -1.0}, "id": "MACPD", "gene_reaction_rule": "ECs3207"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Malonyl-CoA methyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALCOAMT"]}, "metabolites": {"malcoame_c": 1.0, "amet_c": -1.0, "ahcys_c": 1.0, "malcoa_c": -1.0}, "id": "MALCOAMT", "gene_reaction_rule": "ECs0855"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Malate decarboxylating oxidoreductase (decarboxylating)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALDDH"]}, "metabolites": {"pyr_c": 1.0, "co2_c": 1.0, "nadh_c": 1.0, "mal__D_c": -1.0, "nad_c": -1.0}, "id": "MALDDH", "gene_reaction_rule": "ECs2509"}, {"subsystem": "Transport, Inner Membrane", "name": "D-Malate transport via proton symport (2 H) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALDt2_2pp"]}, "metabolites": {"mal__D_p": -1.0, "mal__D_c": 1.0, "h_c": 2.0, "h_p": -2.0}, "id": "MALDt2_2pp", "gene_reaction_rule": "ECs4408"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-Malate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MALDtex"]}, "metabolites": {"mal__D_p": 1.0, "mal__D_e": -1.0}, "id": "MALDtex", "gene_reaction_rule": "ECs3104 or ompN or ECs0268 or ECs1012"}, {"subsystem": "Anaplerotic Reactions", "name": "Malate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALS"]}, "metabolites": {"h2o_c": -1.0, "mal__L_c": 1.0, "coa_c": 1.0, "h_c": 1.0, "accoa_c": -1.0, "glx_c": -1.0}, "id": "MALS", "gene_reaction_rule": "ECs4932"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltose O-acetyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MALTATr"]}, "metabolites": {"acmalt_c": 1.0, "malt_c": -1.0, "coa_c": 1.0, "accoa_c": -1.0}, "id": "MALTATr", "gene_reaction_rule": "ECs0512"}, {"subsystem": "Transport, Inner Membrane", "name": "Maltohexaose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTHXabcpp"]}, "metabolites": {"h2o_c": -1.0, "malthx_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "malthx_p": -1.0, "pi_c": 1.0}, "id": "MALTHXabcpp", "gene_reaction_rule": "ECs5017 and ECs5016 and ECs5015 and ECs5018"}, {"subsystem": "Transport, Outer Membrane", "name": "Maltohexaose transport via diffusion (extracellular to periplasm) irreversible", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTHXtexi"]}, "metabolites": {"malthx_e": -1.0, "malthx_p": 1.0}, "id": "MALTHXtexi", "gene_reaction_rule": "ECs5019"}, {"subsystem": "Transport, Inner Membrane", "name": "Maltopentaose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTPTabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "maltpt_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "maltpt_c": 1.0, "pi_c": 1.0}, "id": "MALTPTabcpp", "gene_reaction_rule": "ECs5017 and ECs5016 and ECs5015 and ECs5018"}, {"subsystem": "Transport, Outer Membrane", "name": "MaltopentaoseMaltotriose transport via diffusion (extracellular to periplasm) irreversible", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTPTtexi"]}, "metabolites": {"maltpt_p": 1.0, "maltpt_e": -1.0}, "id": "MALTPTtexi", "gene_reaction_rule": "ECs5019"}, {"subsystem": "Transport, Inner Membrane", "name": "Maltotriose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTTRabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "malttr_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "malttr_c": 1.0}, "id": "MALTTRabcpp", "gene_reaction_rule": "ECs5017 and ECs5016 and ECs5015 and ECs5018"}, {"subsystem": "Transport, Outer Membrane", "name": "Maltotriose transport via diffusion (extracellular to periplasm) irreversible", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTTRtexi"]}, "metabolites": {"malttr_e": -1.0, "malttr_p": 1.0}, "id": "MALTTRtexi", "gene_reaction_rule": "ECs5019"}, {"subsystem": "Transport, Inner Membrane", "name": "Maltotetraose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTTTRabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "maltttr_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "maltttr_p": -1.0}, "id": "MALTTTRabcpp", "gene_reaction_rule": "ECs5017 and ECs5016 and ECs5015 and ECs5018"}, {"subsystem": "Transport, Outer Membrane", "name": "MaltotetraoseMaltotriose transport via diffusion (extracellular to periplasm) irreversible", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTTTRtexi"]}, "metabolites": {"maltttr_e": -1.0, "maltttr_p": 1.0}, "id": "MALTTTRtexi", "gene_reaction_rule": "ECs5019"}, {"subsystem": "Transport, Inner Membrane", "name": "Maltose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "malt_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "malt_c": 1.0, "pi_c": 1.0}, "id": "MALTabcpp", "gene_reaction_rule": "ECs5017 and ECs5016 and ECs5015 and ECs5018"}, {"subsystem": "Transport, Inner Membrane", "name": "Maltose transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTptspp"]}, "metabolites": {"pep_c": -1.0, "malt_p": -1.0, "pyr_c": 1.0, "malt6p_c": 1.0}, "id": "MALTptspp", "gene_reaction_rule": "ECs3289 and ECs2329 and ECs3287 and ECs3288"}, {"subsystem": "Transport, Outer Membrane", "name": "MaltoseMaltotriose transport via diffusion (extracellular to periplasm) irreversible", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTtexi"]}, "metabolites": {"malt_p": 1.0, "malt_e": -1.0}, "id": "MALTtexi", "gene_reaction_rule": "ECs5019"}, {"subsystem": "Transport, Inner Membrane", "name": "Malate transport via proton symport (2 H) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALt2_2pp"]}, "metabolites": {"mal__L_p": -1.0, "mal__L_c": 1.0, "h_c": 2.0, "h_p": -2.0}, "id": "MALt2_2pp", "gene_reaction_rule": "ECs4408"}, {"subsystem": "Transport, Inner Membrane", "name": "Malate transport via proton symport (3 H) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALt2_3pp"]}, "metabolites": {"mal__L_p": -1.0, "mal__L_c": 1.0, "h_c": 3.0, "h_p": -3.0}, "id": "MALt2_3pp", "gene_reaction_rule": "ECs5105 or ECs5119"}, {"subsystem": "Transport, Inner Membrane", "name": "L-malate transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALt3pp"]}, "metabolites": {"mal__L_p": 1.0, "mal__L_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "MALt3pp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Malate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MALtex"]}, "metabolites": {"mal__L_p": 1.0, "mal__L_e": -1.0}, "id": "MALtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Mannose-1-phosphate guanylyltransferase (GDP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MAN1PT2"]}, "metabolites": {"man1p_c": -1.0, "pi_c": 1.0, "gdp_c": -1.0, "gdpmann_c": 1.0, "h_c": -1.0}, "id": "MAN1PT2", "gene_reaction_rule": "ECs2854"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Mannose-6-phosphate isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MAN6PI"]}, "metabolites": {"man6p_c": -1.0, "f6p_c": 1.0}, "id": "MAN6PI", "gene_reaction_rule": "ECs2319"}, {"subsystem": "Transport, Inner Membrane", "name": "Mannose-6-phosphate transport via phosphate antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MAN6Pt6_2pp"]}, "metabolites": {"man6p_p": -1.0, "pi_p": 2.0, "pi_c": -2.0, "man6p_c": 1.0}, "id": "MAN6Pt6_2pp", "gene_reaction_rule": "ECs4603"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Mannose 6-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MAN6Ptex"]}, "metabolites": {"man6p_p": 1.0, "man6p_e": -1.0}, "id": "MAN6Ptex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Mannonate oxidoreductase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MANAO"]}, "metabolites": {"mana_c": -1.0, "nadh_c": 1.0, "fruur_c": 1.0, "nad_c": -1.0, "h_c": 1.0}, "id": "MANAO", "gene_reaction_rule": "ECs5282"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "2-O-alpha-mannosyl-D-glycerate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MANGLYCtex"]}, "metabolites": {"manglyc_e": -1.0, "manglyc_p": 1.0}, "id": "MANGLYCtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Inner Membrane", "name": "D-mannose transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MANptspp"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "man6p_c": 1.0, "man_p": -1.0}, "id": "MANptspp", "gene_reaction_rule": "ECs2527 and ECs2528 and ECs2529 and ECs3287 and ECs3288"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-mannose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MANtex"]}, "metabolites": {"man_e": -1.0, "man_p": 1.0}, "id": "MANtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-methylcitrate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MCITD"]}, "metabolites": {"2mcit_c": -1.0, "h2o_c": 1.0, "2mcacn_c": 1.0}, "id": "MCITD", "gene_reaction_rule": "ECs0387"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Methylisocitrate lyase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MCITL2"]}, "metabolites": {"pyr_c": 1.0, "succ_c": 1.0, "micit_c": -1.0}, "id": "MCITL2", "gene_reaction_rule": "ECs0385"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-methylcitrate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MCITS"]}, "metabolites": {"h2o_c": -1.0, "ppcoa_c": -1.0, "2mcit_c": 1.0, "coa_c": 1.0, "h_c": 1.0, "oaa_c": -1.0}, "id": "MCITS", "gene_reaction_rule": "ECs0386"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Malonyl-CoA-ACP transacylase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MCOATA"]}, "metabolites": {"coa_c": 1.0, "ACP_c": -1.0, "malACP_c": 1.0, "malcoa_c": -1.0}, "id": "MCOATA", "gene_reaction_rule": "ECs1472 and ECs1470"}, {"subsystem": "Cysteine Metabolism", "name": "3-mercaptopyruvate sulfurtransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MCPST"]}, "metabolites": {"pyr_c": 1.0, "tcynt_c": 1.0, "h_c": 1.0, "mercppyr_c": -1.0, "cyan_c": -1.0}, "id": "MCPST", "gene_reaction_rule": "ECs3387"}, {"subsystem": "Murein Biosynthesis", "name": "Murein crosslinking transpeptidase 1A:(A2pm->D-ala) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MCTP1App"]}, "metabolites": {"murein5p5p_p": -1.0, "murein5px4p_p": 1.0, "ala__D_p": 1.0}, "id": "MCTP1App", "gene_reaction_rule": "ECs0088 or ECs0673 or ECs0153 or ECs4238"}, {"subsystem": "Murein Biosynthesis", "name": "Murein crosslinking transpeptidase 1B:(A2pm->A2pm) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MCTP1Bpp"]}, "metabolites": {"murein5p5p_p": -1.0, "murein5px3p_p": 1.0, "alaala_p": 1.0}, "id": "MCTP1Bpp", "gene_reaction_rule": "ECs0153 or ECs4238"}, {"subsystem": "Murein Biosynthesis", "name": "Murein crosslinking transpeptidase 1A:(A2pm->D-ala) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MCTP2App"]}, "metabolites": {"murein5p5p5p_p": -1.0, "murein5px4px4p_p": 1.0, "ala__D_p": 2.0}, "id": "MCTP2App", "gene_reaction_rule": "ECs0088 or ECs0673 or ECs4238 or ECs0153"}, {"subsystem": "Murein Biosynthesis", "name": "Murein D,D-carboxypeptidase (murein5px4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MDDCP1pp"]}, "metabolites": {"murein4px4p_p": 1.0, "murein5px4p_p": -1.0, "h2o_p": -1.0, "ala__D_p": 1.0}, "id": "MDDCP1pp", "gene_reaction_rule": "ECs0670 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-1.0, "ala__D_p": 1.0, "murein5p4p_p": -1.0, "murein4p4p_p": 1.0}, "id": "MDDCP4pp", "gene_reaction_rule": "ECs0670 or ECs4061 or ECs0919 or ECs2812"}, {"subsystem": "Murein Biosynthesis", "name": "Murein D,D-carboxypeptidase (murein5p3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MDDCP5pp"]}, "metabolites": {"h2o_p": -1.0, "murein5p3p_p": -1.0, "murein4p3p_p": 1.0, "ala__D_p": 1.0}, "id": "MDDCP5pp", "gene_reaction_rule": "ECs0670 or ECs4061 or ECs0919 or ECs2812"}, {"subsystem": "Murein Recycling", "name": "Murein D,D-endopeptidase (murein4px4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MDDEP1pp"]}, "metabolites": {"murein4px4p_p": -1.0, "h2o_p": -1.0, "murein4p4p_p": 1.0}, "id": "MDDEP1pp", "gene_reaction_rule": "ECs4061 or ECs3212 or ECs3021"}, {"subsystem": "Murein Recycling", "name": "Murein D,D-endopeptidase (murein3px4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, 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1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["METSOX2abcpp"]}, "metabolites": {"h2o_c": -1.0, "metsox_R__L_p": -1.0, "atp_c": -1.0, "metsox_R__L_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "METSOX2abcpp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-methionine R-oxide diffusion (extracellular)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["METSOX2tex"]}, "metabolites": {"metsox_R__L_p": 1.0, "metsox_R__L_e": -1.0}, "id": "METSOX2tex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Methionine Metabolism", "name": "L-methionine-S-oxide reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["METSOXR1"]}, "metabolites": {"trdrd_c": -1.0, "trdox_c": 1.0, "h2o_c": 1.0, "met__L_c": 1.0, "metsox_S__L_c": -1.0}, "id": "METSOXR1", "gene_reaction_rule": "(ECs5197 and ECs3448) or (ECs5197 and ECs4714)"}, {"subsystem": "Methionine 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"gene_reaction_rule": "ECs0200 and ECs0201 and ECs0199"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-methionine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["METtex"]}, "metabolites": {"met__L_e": -1.0, "met__L_p": 1.0}, "id": "METtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Magnesium (Mg+2) transport in/out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MG2t3_2pp"]}, "metabolites": {"mg2_p": -1.0, "h_c": -2.0, "h_p": 2.0, "mg2_c": 1.0}, "id": "MG2t3_2pp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Magnesium (Mg+2) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MG2tex"]}, "metabolites": {"mg2_e": -1.0, "mg2_p": 1.0}, "id": "MG2tex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Magnesium (+2) transport in via diffusion", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MG2tpp"]}, "metabolites": {"mg2_c": 1.0, "mg2_p": -1.0}, "id": "MG2tpp", "gene_reaction_rule": "ECs4746"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Magnesium (Mg+2) ABC transporter (ubtake, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MG2uabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "mg2_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "mg2_c": 1.0}, "id": "MG2uabcpp", "gene_reaction_rule": "ECs5219"}, {"subsystem": "Methylglyoxal Metabolism", "name": "Methylglyoxal synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MGSA"]}, "metabolites": {"dhap_c": -1.0, "pi_c": 1.0, "mthgxl_c": 1.0}, "id": "MGSA", "gene_reaction_rule": "ECs1047"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Myo-inositol 1-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MI1PP"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "inost_c": 1.0, "mi1p__D_c": -1.0}, "id": "MI1PP", "gene_reaction_rule": "ECs3399"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-methylisocitrate dehydratase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MICITDr"]}, "metabolites": {"2mcacn_c": -1.0, "h2o_c": -1.0, "micit_c": 1.0}, "id": "MICITDr", "gene_reaction_rule": "ECs0122"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Minocycline transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MINCYCtex"]}, "metabolites": {"mincyc_e": -1.0, "mincyc_p": 1.0}, "id": "MINCYCtex", "gene_reaction_rule": "ompN or ECs3104 or ECs1012 or ECs0268"}, {"subsystem": "Transport, Outer Membrane", "name": "Minocycline transport via TolC system", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MINCYCtpp"]}, "metabolites": {"h_p": -1.0, "mincyc_e": 1.0, "h_c": 1.0, "mincyc_p": -1.0}, "id": "MINCYCtpp", "gene_reaction_rule": "ECs0516 and ECs3332 and ECs3923"}, {"subsystem": "Transport, Outer Membrane", "name": "Myo-inositol phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MINOHPtexi"]}, "metabolites": {"minohp_p": 1.0, "minohp_e": -1.0}, "id": "MINOHPtexi", "gene_reaction_rule": ""}, {"subsystem": "Murein Biosynthesis", "name": "Murein L,D-carboxypeptidase (murein5px4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDCP1App"]}, "metabolites": {"murein5px4p_p": -1.0, "murein3px4p_p": 1.0, "alaala_p": 1.0, "h2o_p": -1.0}, "id": "MLDCP1App", "gene_reaction_rule": ""}, {"subsystem": "Murein Biosynthesis", "name": "Murein L,D-carboxypeptidase (murein4p4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDCP1Bpp"]}, "metabolites": {"h2o_p": -1.0, "ala__D_p": 1.0, "murein4p3p_p": 1.0, "murein4p4p_p": -1.0}, "id": "MLDCP1Bpp", "gene_reaction_rule": ""}, {"subsystem": "Murein Biosynthesis", "name": "Murein L,D-carboxypeptidase (murein5p5p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDCP2App"]}, "metabolites": {"murein5p5p_p": -1.0, "murein5p3p_p": 1.0, "alaala_p": 1.0, "h2o_p": -1.0}, "id": "MLDCP2App", "gene_reaction_rule": ""}, {"subsystem": "Murein Biosynthesis", "name": "Murein L,D-carboxypeptidase (murein4p3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDCP2Bpp"]}, "metabolites": {"h2o_p": -1.0, "ala__D_p": 1.0, "murein4p3p_p": -1.0, "murein3p3p_p": 1.0}, "id": "MLDCP2Bpp", "gene_reaction_rule": ""}, {"subsystem": "Murein Biosynthesis", "name": "Murein L,D-carboxypeptidase (murein5px3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDCP3App"]}, "metabolites": {"h2o_p": -1.0, "murein3px3p_p": 1.0, "murein5px3p_p": -1.0, "alaala_p": 1.0}, "id": "MLDCP3App", "gene_reaction_rule": ""}, {"subsystem": "Murein Recycling", "name": "Murein L,D-endopeptidase (murein3px3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDEP1pp"]}, "metabolites": {"murein3p3p_p": 1.0, "murein3px3p_p": -1.0, "h2o_p": -1.0}, "id": "MLDEP1pp", "gene_reaction_rule": ""}, {"subsystem": "Murein Recycling", "name": "Murein L,D-endopeptidase (murein5px3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDEP2pp"]}, "metabolites": {"h2o_p": -1.0, "murein5px3p_p": -1.0, "murein5p3p_p": 1.0}, "id": "MLDEP2pp", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltotriose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG1"]}, "metabolites": {"glc__D_c": 1.0, "malt_c": 1.0, "h2o_c": -1.0, "malttr_c": -1.0}, "id": "MLTG1", "gene_reaction_rule": "ECs0453"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltotetraose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG2"]}, "metabolites": {"glc__D_c": 1.0, "h2o_c": -1.0, "malttr_c": 1.0, "maltttr_c": -1.0}, "id": "MLTG2", "gene_reaction_rule": "ECs0453"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltopentaose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG3"]}, "metabolites": {"maltpt_c": -1.0, "glc__D_c": 1.0, "h2o_c": -1.0, "maltttr_c": 1.0}, "id": "MLTG3", "gene_reaction_rule": "ECs0453"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltohexaose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG4"]}, "metabolites": {"maltpt_c": 1.0, "glc__D_c": 1.0, "h2o_c": -1.0, "malthx_c": -1.0}, "id": "MLTG4", "gene_reaction_rule": "ECs0453"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltoheptaose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG5"]}, "metabolites": {"glc__D_c": 1.0, "malthp_c": -1.0, "h2o_c": -1.0, "malthx_c": 1.0}, "id": "MLTG5", "gene_reaction_rule": "ECs0453"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein4p4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY1pp"]}, "metabolites": {"murein4p4p_p": -1.0, "anhgm4p_p": 2.0}, "id": "MLTGY1pp", "gene_reaction_rule": "ECs3424 or ECs3839 or ECs5350 or ECs3673 or ECs3558 or ECs1687"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein4p3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY2pp"]}, "metabolites": {"murein4p3p_p": -1.0, "anhgm3p_p": 1.0, "anhgm4p_p": 1.0}, "id": "MLTGY2pp", "gene_reaction_rule": "ECs1687 or ECs3424 or ECs3839 or ECs5350 or ECs3673 or ECs3558"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein3p3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY3pp"]}, "metabolites": {"murein3p3p_p": -1.0, "anhgm3p_p": 2.0}, "id": "MLTGY3pp", "gene_reaction_rule": "ECs1687 or ECs3839 or ECs3424 or ECs5350 or ECs3673 or ECs3558"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein4px4p4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY4pp"]}, "metabolites": {"murein4px4p_p": 1.0, "murein4px4p4p_p": -1.0, "anhgm4p_p": 1.0}, "id": "MLTGY4pp", "gene_reaction_rule": "ECs3558 or ECs1687 or ECs3839 or ECs3424 or ECs5350 or ECs3673"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin phosphorylase (maltopentaose)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MLTP1"]}, "metabolites": {"maltpt_c": -1.0, "pi_c": -1.0, "g1p_c": 1.0, "maltttr_c": 1.0}, "id": "MLTP1", "gene_reaction_rule": "ECs4259"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin phosphorylase (maltohexaose)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MLTP2"]}, "metabolites": {"maltpt_c": 1.0, "pi_c": -1.0, "malthx_c": -1.0, "g1p_c": 1.0}, "id": "MLTP2", "gene_reaction_rule": "ECs4259"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin phosphorylase (maltoheptaose)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MLTP3"]}, "metabolites": {"malthx_c": 1.0, "pi_c": -1.0, "malthp_c": -1.0, "g1p_c": 1.0}, "id": "MLTP3", "gene_reaction_rule": "ECs4259"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Methylmalonyl-CoA decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MMCD"]}, "metabolites": {"mmcoa__S_c": -1.0, "co2_c": 1.0, "h_c": -1.0, "ppcoa_c": 1.0}, "id": "MMCD", "gene_reaction_rule": "ECs3789"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "S-methyl-L-methionine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MMETtex"]}, "metabolites": {"mmet_e": -1.0, "mmet_p": 1.0}, "id": "MMETtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Methylmalonyl-CoA mutase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MMM"]}, "metabolites": {"mmcoa__S_c": 1.0, "succoa_c": -1.0}, "id": "MMM", "gene_reaction_rule": "ECs3787"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Manganese (Mn+2) transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MN2t3pp"]}, "metabolites": {"mn2_p": 1.0, "mn2_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "MN2t3pp", "gene_reaction_rule": "ECs4840 or ECs0780"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Manganese transport in via permease (no H+)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MN2tpp"]}, "metabolites": {"mn2_p": -1.0, "mn2_c": 1.0}, "id": "MN2tpp", "gene_reaction_rule": "ECs3928"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Mannose 6-phosphate phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MN6PP"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "man6p_c": -1.0, "man_c": 1.0}, "id": "MN6PP", "gene_reaction_rule": "ECs0899"}, {"subsystem": "Transport, Inner Membrane", "name": "Mannitol transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MNLptspp"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "mnl_p": -1.0, "mnl1p_c": 1.0}, "id": "MNLptspp", "gene_reaction_rule": "ECs4475 and ECs3287 and ECs3288"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Mannitol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MNLtex"]}, "metabolites": {"mnl_p": 1.0, "mnl_e": -1.0}, "id": "MNLtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Alternate Carbon Metabolism", "name": "D-mannonate hydrolyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MNNH"]}, "metabolites": {"h2o_c": 1.0, "2ddglcn_c": 1.0, "mana_c": -1.0}, "id": "MNNH", "gene_reaction_rule": "ECs5281"}, {"subsystem": "Transport, Inner Membrane", "name": "Manganese (Mn+2) transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MNt2pp"]}, "metabolites": {"mn2_p": -1.0, "mn2_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "MNt2pp", "gene_reaction_rule": "ECs3271"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Manganese (Mn+2) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MNtex"]}, "metabolites": {"mn2_p": 1.0, "mn2_e": -1.0}, "id": "MNtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "MoaD sulfuration (nadh, assumed)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOADSUx"]}, "metabolites": {"iscssh_c": -1.0, "moadcosh_c": 1.0, "iscs_c": 1.0, "moadamp_c": -1.0, "amp_c": 1.0, "nad_c": 1.0, "nadh_c": -1.0}, "id": "MOADSUx", "gene_reaction_rule": "ECs3396 and ECs0862"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "3-deoxy-D-manno-octulosonic acid transferase", "upper_bound": 1000.0, "lower_bound": 0.0, 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and ECs3296 and ECs3295 and ECs3294)"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Molybdate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MOBDtex"]}, "metabolites": {"mobd_e": -1.0, "mobd_p": 1.0}, "id": "MOBDtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Molybdopterin cytidine dinucleotide synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOCDS"]}, "metabolites": {"ctp_c": -1.0, "mococdp_c": 1.0, "ppi_c": 1.0, "h_c": -1.0, "moco_c": -1.0}, "id": "MOCDS", "gene_reaction_rule": "ECs3750"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Molybdenum cofactor synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOCOS"]}, "metabolites": {"cu2_c": 1.0, "h2o_c": 1.0, "mobd_c": -1.0, "moco_c": 1.0, "amp_c": 1.0, "mptamp_c": -1.0, "h_c": -2.0}, "id": "MOCOS", "gene_reaction_rule": "ECs0905"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Molybdopterin guanine dinucleotide synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOGDS"]}, "metabolites": {"moco_c": -1.0, "ppi_c": 1.0, "gtp_c": -1.0, "h_c": -1.0, "mocogdp_c": 1.0}, "id": "MOGDS", "gene_reaction_rule": "ECs4780 or (ECs4780 and ECs4779)"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "3-methyl-2-oxobutanoate hydroxymethyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOHMT"]}, "metabolites": {"thf_c": 1.0, "h2o_c": -1.0, "mlthf_c": -1.0, "2dhp_c": 1.0, "3mob_c": -1.0}, "id": "MOHMT", "gene_reaction_rule": "ECs0138"}, {"subsystem": "Citric Acid Cycle", "name": "Malate oxidase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MOX"]}, "metabolites": {"h2o2_c": 1.0, "mal__L_c": -1.0, "oaa_c": 1.0, "o2_c": -1.0}, "id": "MOX", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Molybdopterin adenylyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MPTAT"]}, "metabolites": {"mpt_c": -1.0, "ppi_c": 1.0, "h_c": -1.0, "atp_c": -1.0, "mptamp_c": 1.0}, "id": "MPTAT", "gene_reaction_rule": "ECs0009"}, {"subsystem": "Murein Biosynthesis", "name": "Murein polymerizing transglycosylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MPTG"]}, "metabolites": {"udcpdp_c": 2.0, "uaagmda_c": -2.0, "h_c": 2.0, "murein5p5p_p": 1.0}, "id": "MPTG", "gene_reaction_rule": "(ECs4238 and ECs1447) or (ECs0153 and ECs1447) or (ECs1447 and ECs3385)"}, {"subsystem": "Murein Biosynthesis", "name": "Murein polymerizing transglycosylase 2 (three linked units)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MPTG2"]}, "metabolites": {"murein5p5p5p_p": 1.0, "uaagmda_c": -1.0, "udcpdp_c": 1.0, "h_c": 1.0, "murein5p5p_p": -1.0}, "id": "MPTG2", "gene_reaction_rule": "(ECs4238 and ECs1447) or (ECs0153 and ECs1447) or (ECs1447 and ECs3385)"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Molybdopterin synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MPTS"]}, "metabolites": {"cu2_c": -1.0, "mpt_c": 1.0, "moadcosh_c": -2.0, "cpmp_c": -1.0, "h_c": 5.0, "moadcoo_c": 2.0}, "id": "MPTS", "gene_reaction_rule": "ECs0862 and ECs0863"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Molybdopterin synthase sulfurylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MPTSS"]}, "metabolites": {"moadamp_c": 1.0, "ppi_c": 1.0, "h_c": -1.0, "atp_c": -1.0, "moadcoo_c": -1.0}, "id": "MPTSS", "gene_reaction_rule": "ECs0904"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Malonic semialdehyde reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MSAR"]}, "metabolites": {"3hpp_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "msa_c": -1.0}, "id": "MSAR", "gene_reaction_rule": "ECs1254 or ECs2148"}, {"subsystem": "Transport, Inner Membrane", "name": "Methanesulfonate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MSO3abcpp"]}, "metabolites": {"h2o_c": -1.0, "mso3_c": 1.0, "atp_c": -1.0, "mso3_p": -1.0, "adp_c": 1.0, "pi_c": 1.0, "h_c": 1.0}, "id": "MSO3abcpp", "gene_reaction_rule": "ECs1019 and ECs1016 and ECs1017"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Methanesulfonate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MSO3tex"]}, "metabolites": {"mso3_e": -1.0, "mso3_p": 1.0}, "id": "MSO3tex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Methylthioadenosine nucleosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MTAN"]}, "metabolites": {"5mta_c": -1.0, "h2o_c": -1.0, "ade_c": 1.0, "5mtr_c": 1.0}, "id": "MTAN", "gene_reaction_rule": "ECs0163"}, {"subsystem": "Folate Metabolism", "name": "Methenyltetrahydrofolate cyclohydrolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MTHFC"]}, "metabolites": {"h_c": 1.0, "h2o_c": -1.0, "methf_c": -1.0, "10fthf_c": 1.0}, "id": "MTHFC", "gene_reaction_rule": "ECs0591"}, {"subsystem": "Folate Metabolism", "name": "Methylenetetrahydrofolate dehydrogenase (NADP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MTHFD"]}, "metabolites": {"nadp_c": -1.0, "nadph_c": 1.0, "methf_c": 1.0, "mlthf_c": -1.0}, "id": "MTHFD", "gene_reaction_rule": "ECs0591"}, {"subsystem": "Folate Metabolism", "name": "5,10-methylenetetrahydrofolate reductase (NADH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MTHFR2"]}, "metabolites": {"nad_c": 1.0, "nadh_c": -1.0, "h_c": -2.0, "mlthf_c": -1.0, "5mthf_c": 1.0}, "id": "MTHFR2", "gene_reaction_rule": "ECs4870"}, {"subsystem": "Methionine Metabolism", "name": "(2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran synthesis (spontaneous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MTHTHFSs"]}, "metabolites": {"h2o_c": -1.0, "mththf_c": 1.0, "mdhdhf_c": -1.0}, "id": "MTHTHFSs", "gene_reaction_rule": "s0001"}, {"subsystem": "Glycine and Serine Metabolism", "name": "N-methyltryptophan oxidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MTRPOX"]}, "metabolites": {"o2_c": -1.0, "h2o_c": -1.0, "Nmtrp_c": -1.0, "fald_c": 1.0, "h2o2_c": 1.0, "trp__L_c": 1.0}, "id": "MTRPOX", "gene_reaction_rule": "ECs1437"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Nitrious oxide transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["N2Otex"]}, "metabolites": {"n2o_p": 1.0, "n2o_e": -1.0}, "id": "N2Otex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Nitrious oxide transport (diffusion)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["N2Otpp"]}, "metabolites": {"n2o_c": 1.0, "n2o_p": -1.0}, "id": "N2Otpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Arginine and Proline Metabolism", "name": "N-acetylornithine deacetylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACODA"]}, "metabolites": {"glu5sa_c": 1.0, "h2o_c": -1.0, "ac_c": 1.0, "acg5sa_c": -1.0}, "id": "NACODA", "gene_reaction_rule": "ECs4886"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Nicotinic acid transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NACtex"]}, "metabolites": {"nac_e": -1.0, "nac_p": 1.0}, "id": "NACtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Inner Membrane", "name": "Nicotinic acid uptake (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACtpp"]}, "metabolites": {"nac_c": 1.0, "nac_p": -1.0}, "id": "NACtpp", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NAD diphosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADDP"]}, "metabolites": {"h2o_c": -1.0, "nmn_c": 1.0, "h_c": 2.0, "nad_c": -1.0, "amp_c": 1.0}, "id": "NADDP", "gene_reaction_rule": "ECs4919 or ECs3283"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (menaquinone-8 & 0 protons)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH10"]}, "metabolites": {"mql8_c": 1.0, "nadh_c": -1.0, "mqn8_c": -1.0, "h_c": -1.0, "nad_c": 1.0}, "id": "NADH10", "gene_reaction_rule": "ECs1487"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (ubiquinone-8 & 3 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH16pp"]}, "metabolites": {"h_p": 3.0, "q8h2_c": 1.0, "h_c": -4.0, "nad_c": 1.0, "nadh_c": -1.0, "q8_c": -1.0}, "id": "NADH16pp", "gene_reaction_rule": "ECs3160 and ECs3161 and ECs3162 and ECs3163 and ECs3164 and ECs3165 and ECs3166 and ECs3167 and ECs3168 and ECs3169 and ECs3170 and ECs3171 and ECs3172"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (menaquinone-8 & 3 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH17pp"]}, "metabolites": {"mqn8_c": -1.0, "h_p": 3.0, "h_c": -4.0, "nad_c": 1.0, "nadh_c": -1.0, "mql8_c": 1.0}, "id": "NADH17pp", "gene_reaction_rule": "ECs3160 and ECs3161 and ECs3162 and ECs3163 and ECs3164 and ECs3165 and ECs3166 and ECs3167 and ECs3168 and ECs3169 and ECs3170 and ECs3171 and ECs3172"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (demethylmenaquinone-8 & 3 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH18pp"]}, "metabolites": {"2dmmq8_c": -1.0, "h_p": 3.0, "2dmmql8_c": 1.0, "h_c": -4.0, "nad_c": 1.0, "nadh_c": -1.0}, "id": "NADH18pp", "gene_reaction_rule": "ECs3160 and ECs3161 and ECs3162 and ECs3163 and ECs3164 and ECs3165 and ECs3166 and ECs3167 and ECs3168 and ECs3169 and ECs3170 and ECs3171 and ECs3172"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (ubiquinone-8 )", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH5"]}, "metabolites": {"q8h2_c": 1.0, "nadh_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "q8_c": -1.0}, "id": "NADH5", "gene_reaction_rule": "ECs1487"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (demethylmenaquinone-8 & 0 protons)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH9"]}, "metabolites": {"nad_c": 1.0, "nadh_c": -1.0, "2dmmq8_c": -1.0, "2dmmql8_c": 1.0, "h_c": -1.0}, "id": "NADH9", "gene_reaction_rule": "ECs1487"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NAD kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADK"]}, "metabolites": {"adp_c": 1.0, "nadp_c": 1.0, "h_c": 1.0, "nad_c": -1.0, "atp_c": -1.0}, "id": "NADK", "gene_reaction_rule": "ECs3477"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NAD nucleosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADN"]}, "metabolites": {"h_c": 1.0, "h2o_c": -1.0, "adprib_c": 1.0, "nad_c": -1.0, "ncam_c": 1.0}, "id": "NADN", "gene_reaction_rule": ""}, {"subsystem": "Oxidative Phosphorylation", "name": "NADPH Quinone Reductase (Ubiquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPHQR2"]}, "metabolites": {"q8h2_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "q8_c": -1.0, "h_c": -1.0}, "id": "NADPHQR2", "gene_reaction_rule": "ECs3910"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADPH Quinone Reductase (Menaquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPHQR3"]}, "metabolites": {"nadph_c": -1.0, "nadp_c": 1.0, "mqn8_c": -1.0, "h_c": -1.0, "mql8_c": 1.0}, "id": "NADPHQR3", "gene_reaction_rule": "ECs3910"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADPH Quinone Reductase (2-Demethylmenaquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPHQR4"]}, "metabolites": {"nadp_c": 1.0, "nadph_c": -1.0, "2dmmq8_c": -1.0, "2dmmql8_c": 1.0, "h_c": -1.0}, "id": "NADPHQR4", "gene_reaction_rule": "ECs3910"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NADP phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPPPS"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "nadp_c": -1.0, "nad_c": 1.0}, "id": "NADPPPS", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NAD synthase (nh3)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADS1"]}, "metabolites": {"dnad_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "h_c": 1.0, "nad_c": 1.0, "nh4_c": -1.0, "amp_c": 1.0}, "id": "NADS1", "gene_reaction_rule": "ECs2446"}, {"subsystem": "Oxidative Phosphorylation", "name": "NAD transhydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADTRHD"]}, "metabolites": {"nadp_c": 1.0, "nadph_c": -1.0, "nadh_c": 1.0, "nad_c": -1.0}, "id": "NADTRHD", "gene_reaction_rule": "ECs4891 or (ECs2308 and ECs2309)"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Nicotinic acid mononucleotide pyrophosphorylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAMNPP"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "nicrnt_c": 1.0, "ppi_c": 1.0, "nac_c": -1.0, "adp_c": 1.0, "pi_c": 1.0, "prpp_c": -1.0}, "id": "NAMNPP", "gene_reaction_rule": "ECs1014"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Sodium proton antiporter (H:NA is 1.5) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAt3_1p5pp"]}, "metabolites": {"na1_p": 2.0, "na1_c": -2.0, "h_c": 3.0, "h_p": -3.0}, "id": "NAt3_1p5pp", "gene_reaction_rule": "ECs1681"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Sodium proton antiporter (H:NA is 2) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAt3_2pp"]}, "metabolites": {"na1_p": 1.0, "na1_c": -1.0, "h_c": 2.0, "h_p": -2.0}, "id": "NAt3_2pp", "gene_reaction_rule": "ECs0017"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Sodium transport out via proton antiport (cytoplasm to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAt3pp"]}, "metabolites": {"na1_p": 1.0, "na1_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "NAt3pp", "gene_reaction_rule": "ECs0922 or ECs1721"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Sodium transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NAtex"]}, "metabolites": {"na1_p": 1.0, "na1_e": -1.0}, "id": "NAtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:GDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK1"]}, "metabolites": {"gdp_c": -1.0, "gtp_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "NDPK1", "gene_reaction_rule": "ECs0527 or ECs3380"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:UDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK2"]}, "metabolites": {"utp_c": 1.0, "udp_c": -1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "NDPK2", "gene_reaction_rule": "ECs0527 or ECs3380"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:CDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK3"]}, "metabolites": {"ctp_c": 1.0, "cdp_c": -1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "NDPK3", "gene_reaction_rule": "ECs3380 or ECs0527"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:dTDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK4"]}, "metabolites": {"dtdp_c": -1.0, "dttp_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "NDPK4", "gene_reaction_rule": "ECs0527 or ECs3380"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:dGDP)", "upper_bound": 1000.0, 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"ECs3598"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "5'-nucleotidase (GMP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NTD9pp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "gmp_p": -1.0, "gsn_p": 1.0}, "id": "NTD9pp", "gene_reaction_rule": "ECs0533 or ECs5037"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-triphosphatase (ATP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NTP1"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "NTP1", "gene_reaction_rule": "ECs0689 or ECs5140"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-triphosphatase (ITP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NTP10"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "h_c": 1.0, "itp_c": -1.0, "idp_c": 1.0}, "id": "NTP10", "gene_reaction_rule": "ECs5140 or ECs5352"}, {"subsystem": "Nucleotide Salvage Pathway", "name": 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["PGPP140pp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "pg140_p": 1.0, "pgp140_p": -1.0}, "id": "PGPP140pp", "gene_reaction_rule": "ECs0471 or ECs1851"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylglycerol phosphate phosphatase (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PGPP141"]}, "metabolites": {"pg141_c": 1.0, "pgp141_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0}, "id": "PGPP141", "gene_reaction_rule": "ECs1851 or ECs0471"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylglycerol phosphate phosphatase (periplasm, n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PGPP141pp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "pgp141_p": -1.0, "pg141_p": 1.0}, "id": "PGPP141pp", "gene_reaction_rule": "ECs0471 or ECs1851"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylglycerol phosphate phosphatase (n-C16:0)", "upper_bound": 1000.0, 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phosphatase (periplasm, n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PGPP161pp"]}, "metabolites": {"pgp161_p": -1.0, "pg161_p": 1.0, "pi_p": 1.0, "h2o_p": -1.0}, "id": "PGPP161pp", "gene_reaction_rule": "ECs0471 or ECs1851"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylglycerol phosphate phosphatase (n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PGPP180"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "pgp180_c": -1.0, "pg180_c": 1.0}, "id": "PGPP180", "gene_reaction_rule": "ECs0471 or ECs1851"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylglycerol phosphate phosphatase (periplasm, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PGPP180pp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "pg180_p": 1.0, "pgp180_p": -1.0}, "id": "PGPP180pp", "gene_reaction_rule": "ECs0471 or ECs1851"}, {"subsystem": "Glycerophospholipid 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{"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylglycerol synthase (n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PGSA140"]}, "metabolites": {"pgp140_c": 1.0, "cdpdtdecg_c": -1.0, "glyc3p_c": -1.0, "h_c": 1.0, "cmp_c": 1.0}, "id": "PGSA140", "gene_reaction_rule": "ECs2650"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylglycerol synthase (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PGSA141"]}, "metabolites": {"pgp141_c": 1.0, "glyc3p_c": -1.0, "cdpdtdec7eg_c": -1.0, "h_c": 1.0, "cmp_c": 1.0}, "id": "PGSA141", "gene_reaction_rule": "ECs2650"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylglycerol synthase (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PGSA160"]}, "metabolites": {"pgp160_c": 1.0, "glyc3p_c": -1.0, "cmp_c": 1.0, "h_c": 1.0, "cdpdhdecg_c": -1.0}, "id": "PGSA160", "gene_reaction_rule": 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Dioxygenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPPNDO"]}, "metabolites": {"o2_c": -1.0, "pppn_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "cechddd_c": 1.0, "nadh_c": -1.0}, "id": "PPPNDO", "gene_reaction_rule": "ECs3404 and ECs3405 and ECs3406 and ECs3408"}, {"subsystem": "Transport, Inner Membrane", "name": "3-phenylpropionate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PPPNt2rpp"]}, "metabolites": {"pppn_p": -1.0, "pppn_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "PPPNt2rpp", "gene_reaction_rule": "ECs3402"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "3-phenylpropionate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PPPNtex"]}, "metabolites": {"pppn_p": 1.0, "pppn_e": -1.0}, "id": "PPPNtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Phosphoenolpyruvate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPS"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "pyr_c": -1.0, "pep_c": 1.0, "h_c": 2.0, "pi_c": 1.0, "amp_c": 1.0}, "id": "PPS", "gene_reaction_rule": "ECs2409"}, {"subsystem": "Unassigned", "name": "Phosphonate hydrogenase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPTHpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "ppt_p": -1.0, "h2_p": 1.0}, "id": "PPTHpp", "gene_reaction_rule": "ECs0433"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Phosphonate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PPTtex"]}, "metabolites": {"ppt_e": -1.0, "ppt_p": 1.0}, "id": "PPTtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Purine and Pyrimidine 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Metabolism", "name": "Phosphoribosyl-AMP cyclohydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PRAMPC"]}, "metabolites": {"prfp_c": 1.0, "h2o_c": -1.0, "prbamp_c": -1.0}, "id": "PRAMPC", "gene_reaction_rule": "ECs2827"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylaminoimidazolesuccinocarboxamide synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PRASCSi", "PRASCS"]}, "metabolites": {"atp_c": -1.0, "5aizc_c": -1.0, "asp__L_c": -1.0, "25aics_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "PRASCSi_copy1", "gene_reaction_rule": "ECs3338"}, {"subsystem": "Histidine Metabolism", "name": "Phosphoribosyl-ATP pyrophosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PRATPP"]}, "metabolites": {"h2o_c": -1.0, "ppi_c": 1.0, "prbamp_c": 1.0, "h_c": 1.0, "prbatp_c": -1.0}, "id": "PRATPP", "gene_reaction_rule": "ECs2827"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylformylglycinamidine synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PRFGS"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "glu__L_c": 1.0, "fgam_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "fpram_c": 1.0, "pi_c": 1.0, "gln__L_c": -1.0}, "id": "PRFGS", "gene_reaction_rule": "ECs3423"}, {"subsystem": "Histidine Metabolism", "name": "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PRMICI"]}, "metabolites": {"prfp_c": -1.0, "prlp_c": 1.0}, "id": "PRMICI", "gene_reaction_rule": "ECs2825"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Proline dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PROD2"]}, "metabolites": {"1pyr5c_c": 1.0, "fadh2_c": 1.0, "pro__L_c": -1.0, "h_c": 1.0, "fad_c": -1.0}, "id": "PROD2", "gene_reaction_rule": "ECs1260"}, {"subsystem": "Transport, Inner Membrane", "name": "L-Prolinylglycine (Pro-Gly) transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PROGLYabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "progly_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "progly_p": -1.0}, "id": "PROGLYabcpp", "gene_reaction_rule": "ECs4424 and ECs4423 and ECs4422 and ECs4421 and ECs4420"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-Prolinylglycine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PROGLYtex"]}, "metabolites": {"progly_e": -1.0, "progly_p": 1.0}, "id": "PROGLYtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "tRNA Charging", "name": "Prolyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PROTRS"]}, "metabolites": {"atp_c": -1.0, "trnapro_c": -1.0, "ppi_c": 1.0, "pro__L_c": -1.0, "protrna_c": 1.0, "amp_c": 1.0}, "id": "PROTRS", "gene_reaction_rule": "ECs0196"}, {"subsystem": "Transport, Inner Membrane", "name": "L-proline transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PROabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "pro__L_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pro__L_p": -1.0, "pi_c": 1.0}, "id": "PROabcpp", "gene_reaction_rule": "ECs3540 and ECs3541 and ECs3542"}, {"subsystem": "Transport, Inner Membrane", "name": "L-proline reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PROt2rpp"]}, "metabolites": {"pro__L_p": -1.0, "pro__L_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "PROt2rpp", "gene_reaction_rule": "ECs5093"}, {"subsystem": "Transport, Inner Membrane", "name": "Na+/Proline-L symporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PROt4pp"]}, "metabolites": {"pro__L_p": -1.0, "na1_p": -1.0, "pro__L_c": 1.0, "na1_c": 1.0}, "id": "PROt4pp", "gene_reaction_rule": "ECs1261"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-proline transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PROtex"]}, "metabolites": {"pro__L_p": 1.0, "pro__L_e": -1.0}, "id": "PROtex", "gene_reaction_rule": "ompN or ECs3104 or ECs0268 or ECs1012"}, {"subsystem": "Histidine Metabolism", "name": "Phosphoribosylpyrophosphate synthetase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PRPPS"]}, "metabolites": {"prpp_c": 1.0, "r5p_c": -1.0, "h_c": 1.0, "atp_c": -1.0, "amp_c": 1.0}, "id": "PRPPS", "gene_reaction_rule": "ECs1712"}, {"subsystem": "Transport, Inner Membrane", "name": "Psicoselysine transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PSCLYSt2pp"]}, "metabolites": {"psclys_c": 1.0, "h_c": 1.0, "h_p": -1.0, "psclys_p": -1.0}, "id": "PSCLYSt2pp", "gene_reaction_rule": "ECs4221"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Psicoselysine transporter via diffusion (extracellular)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PSCLYStex"]}, "metabolites": {"psclys_e": -1.0, "psclys_p": 1.0}, "id": "PSCLYStex", "gene_reaction_rule": "ECs3104 or ompN or ECs0268 or ECs1012"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "3-phosphoshikimate 1-carboxyvinyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PSCVT"]}, "metabolites": {"pep_c": -1.0, "pi_c": 1.0, "skm5p_c": -1.0, "3psme_c": 1.0}, "id": "PSCVT", "gene_reaction_rule": "ECs0991"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phosphatidylserine decarboxylase (n-C12:0)", 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{"subsystem": "Transport, Outer Membrane", "name": "Rifampin transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["RFAMPtex"]}, "metabolites": {"rfamp_e": -1.0, "rfamp_p": 1.0}, "id": "RFAMPtex", "gene_reaction_rule": "s0001"}, {"subsystem": "Transport, Outer Membrane", "name": "Rifampin transport via TolC system", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RFAMPtpp"]}, "metabolites": {"rfamp_e": 1.0, "rfamp_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "RFAMPtpp", "gene_reaction_rule": "ECs0516 and ECs3332 and ECs3923"}, {"subsystem": "Methionine Metabolism", "name": "S-ribosylhomocysteine cleavage enzyme", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RHCCE"]}, "metabolites": {"hcys__L_c": 1.0, "rhcys_c": -1.0, "dhptd_c": 1.0}, "id": "RHCCE", "gene_reaction_rule": "ECs3549"}, {"subsystem": "Transport, Inner Membrane", "name": "D-ribose transport 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"Alternate Carbon Metabolism", "name": "Rhamnulokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RMK"]}, "metabolites": {"adp_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "rml_c": -1.0, "rml1p_c": 1.0}, "id": "RMK", "gene_reaction_rule": "ECs4831"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-rhamnose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["RMNtex"]}, "metabolites": {"rmn_p": 1.0, "rmn_e": -1.0}, "id": "RMNtex", "gene_reaction_rule": "ECs3104 or ECs0268 or ECs1012 or ompN"}, {"subsystem": "Transport, Inner Membrane", "name": "L-rhamnose transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RMNtpp"]}, "metabolites": {"rmn_c": 1.0, "rmn_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "RMNtpp", "gene_reaction_rule": "rhaT"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Rhamnulose-1-phosphate aldolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["RMPA"]}, "metabolites": {"dhap_c": 1.0, "lald__L_c": 1.0, "rml1p_c": -1.0}, "id": "RMPA", "gene_reaction_rule": "ECs4829"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Ribonucleoside-diphosphate reductase (ADP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RNDR1"]}, "metabolites": {"dadp_c": 1.0, "trdox_c": 1.0, "trdrd_c": -1.0, "adp_c": -1.0, "h2o_c": 1.0}, "id": "RNDR1", "gene_reaction_rule": "((ECs3117 and ECs3118) and ECs3448) or ((ECs3117 and ECs3118) and ECs4714)"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Ribonucleoside-diphosphate reductase (ADP) (glutaredoxin)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RNDR1b"]}, "metabolites": {"dadp_c": 1.0, "h2o_c": 1.0, "grxrd_c": -1.0, "adp_c": -1.0, "grxox_c": 1.0}, "id": "RNDR1b", "gene_reaction_rule": "(ECs1442 and (ECs3538 and 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ECs3539))"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Ribonucleoside-diphosphate reductase (CDP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RNDR3"]}, "metabolites": {"cdp_c": -1.0, "trdox_c": 1.0, "trdrd_c": -1.0, "h2o_c": 1.0, "dcdp_c": 1.0}, "id": "RNDR3", "gene_reaction_rule": "((ECs3117 and ECs3118) and ECs4714) or ((ECs3117 and ECs3118) and ECs3448)"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Ribonucleoside-diphosphate reductase (CDP) (glutaredoxin)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RNDR3b"]}, "metabolites": {"cdp_c": -1.0, "grxox_c": 1.0, "h2o_c": 1.0, "grxrd_c": -1.0, "dcdp_c": 1.0}, "id": "RNDR3b", "gene_reaction_rule": "(ECs0929 and (ECs3538 and ECs3539)) or (ECs4488 and (ECs3538 and ECs3539)) or (ECs2363 and (ECs3538 and ECs3539)) or (ECs1442 and (ECs3538 and ECs3539))"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Ribonucleoside-diphosphate reductase (UDP)", 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"Transport, Outer Membrane Porin", "name": "Sulfoaceate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SULFACtex"]}, "metabolites": {"sulfac_p": 1.0, "sulfac_e": -1.0}, "id": "SULFACtex", "gene_reaction_rule": "ompN or ECs3104 or ECs0268 or ECs1012"}, {"subsystem": "Cysteine Metabolism", "name": "Sulfite reductase (NADPH2)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SULRi"]}, "metabolites": {"h2o_c": 3.0, "nadp_c": 3.0, "nadph_c": -3.0, "so3_c": -1.0, "h2s_c": 1.0, "h_c": -5.0}, "id": "SULRi", "gene_reaction_rule": "ECs3618 and ECs3619"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Sulfate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SULabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "so4_p": -1.0, "so4_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "SULabcpp", "gene_reaction_rule": "(ECs3293 and ECs3296 and ECs3295 and ECs3294) or (ECs0791 and ECs0792 and ECs0793) or (ECs3293 and ECs3295 and ECs3294 and ECs4842)"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Trans-2-decenoyl-ACP isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["T2DECAI"]}, "metabolites": {"tdec2eACP_c": -1.0, "cdec3eACP_c": 1.0}, "id": "T2DECAI", "gene_reaction_rule": "ECs1038"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Tagaturonate reductase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TAGURr"]}, "metabolites": {"tagur_c": 1.0, "nadh_c": 1.0, "altrn_c": -1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "TAGURr", "gene_reaction_rule": "ECs2128"}, {"subsystem": "Pentose Phosphate Pathway", "name": "Transaldolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TALA"]}, "metabolites": {"s7p_c": -1.0, "e4p_c": 1.0, "g3p_c": -1.0, "f6p_c": 1.0}, "id": "TALA", "gene_reaction_rule": "ECs3326 or ECs0008"}, {"subsystem": "Alternate Carbon Metabolism", "name": "L(+)-tartrate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TARTD"]}, "metabolites": {"h2o_c": 1.0, "tartr__L_c": -1.0, "oaa_c": 1.0}, "id": "TARTD", "gene_reaction_rule": "ECs3944 and ECs3945"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-tartrate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TARTRDtex"]}, "metabolites": {"tartr__D_p": 1.0, "tartr__D_e": -1.0}, "id": "TARTRDtex", "gene_reaction_rule": "ompN or ECs3104 or ECs0268 or ECs1012"}, {"subsystem": "Transport, Inner Membrane", "name": "Tartrate/succinate antiporter (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TARTRt7pp"]}, "metabolites": {"tartr__L_p": -1.0, "succ_p": 1.0, "succ_c": -1.0, "tartr__L_c": 1.0}, "id": "TARTRt7pp", 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1.0, "aacald_c": 1.0}, "id": "TAUDO", "gene_reaction_rule": "ECs0422"}, {"subsystem": "Transport, Inner Membrane", "name": "Taurine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TAURabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "taur_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "taur_p": -1.0}, "id": "TAURabcpp", "gene_reaction_rule": "ECs0419 and ECs0420 and ECs0421"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Taurine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TAURtex"]}, "metabolites": {"taur_e": -1.0, "taur_p": 1.0}, "id": "TAURtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Thiocyanate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TCYNTtex"]}, "metabolites": {"tcynt_e": -1.0, "tcynt_p": 1.0}, "id": "TCYNTtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Thiamin pyrophosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TDP"]}, "metabolites": {"thmpp_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0, "h_c": 1.0, "thmmp_c": 1.0}, "id": "TDP", "gene_reaction_rule": "ECs1606"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "DTDP-4-amino-4,6-dideoxy-D-glucose acetyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TDPADGAT"]}, "metabolites": {"dtdp4addg_c": -1.0, "dtdp4aaddg_c": 1.0, "coa_c": 1.0, "h_c": 1.0, "accoa_c": -1.0}, "id": "TDPADGAT", "gene_reaction_rule": "ECs4723"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "DTDP-4-amino-4,6-dideoxy-D-glucose transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TDPAGTA"]}, "metabolites": {"akg_c": 1.0, "dtdp4addg_c": 1.0, "glu__L_c": -1.0, "dtdp4d6dg_c": -1.0}, "id": "TDPAGTA", "gene_reaction_rule": "ECs4724"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "DTDPglucose 4,6-dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TDPGDH"]}, "metabolites": {"dtdpglu_c": -1.0, "h2o_c": 1.0, "dtdp4d6dg_c": 1.0}, "id": "TDPGDH", "gene_reaction_rule": "ECs4721"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Tetraacyldisaccharide 4'kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TDSK"]}, "metabolites": {"lipidAds_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "lipidA_c": 1.0}, "id": "TDSK", "gene_reaction_rule": "ECs0998"}, {"subsystem": "Transport, Inner Membrane", "name": "Thiol:disulfide reductase (DsbC)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TDSR1"]}, "metabolites": {"dsbcrd_p": 1.0, "dsbdox_c": 1.0, 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"lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TKT2"]}, "metabolites": {"e4p_c": -1.0, "xu5p__D_c": -1.0, "g3p_c": 1.0, "f6p_c": 1.0}, "id": "TKT2", "gene_reaction_rule": "ECs3327"}, {"subsystem": "Oxidative Phosphorylation", "name": "Trimethylamine N-oxide reductase (menaquinol 8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TMAOR1"]}, "metabolites": {"h2o_c": 1.0, "mqn8_c": 1.0, "h_c": -1.0, "tmao_c": -1.0, "tma_c": 1.0, "mql8_c": -1.0}, "id": "TMAOR1", "gene_reaction_rule": "ECs0979 and ECs0980 and ECs0981"}, {"subsystem": "Oxidative Phosphorylation", "name": "Trimethylamine N-oxide reductase (menaquinol 8) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TMAOR1pp"]}, "metabolites": {"mqn8_c": 1.0, "h_p": -1.0, "tmao_p": -1.0, "tma_p": 1.0, "h2o_p": 1.0, "mql8_c": -1.0}, "id": "TMAOR1pp", "gene_reaction_rule": "ECs1151 and ECs1152"}, {"subsystem": "Oxidative Phosphorylation", "name": "Trimethylamine N-oxide reductase (demethylmenaquinol 8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TMAOR2"]}, "metabolites": {"h2o_c": 1.0, "2dmmq8_c": 1.0, "2dmmql8_c": -1.0, "h_c": -1.0, "tmao_c": -1.0, "tma_c": 1.0}, "id": "TMAOR2", "gene_reaction_rule": "ECs0979 and ECs0980 and ECs0981"}, {"subsystem": "Oxidative Phosphorylation", "name": "Trimethylamine N-oxide reductase (demethylmenaquinol 8) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TMAOR2pp"]}, "metabolites": {"2dmmq8_c": 1.0, "h_p": -1.0, "tmao_p": -1.0, "tma_p": 1.0, "h2o_p": 1.0, "2dmmql8_c": -1.0}, "id": "TMAOR2pp", "gene_reaction_rule": "ECs1151 and ECs1152"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Trimethylamine N-oxide transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TMAOtex"]}, "metabolites": {"tmao_p": 1.0, "tmao_e": -1.0}, "id": "TMAOtex", 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"gene_reaction_rule": "ECs5341"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Thymidylate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TMDS"]}, "metabolites": {"dump_c": -1.0, "dtmp_c": 1.0, "dhf_c": 1.0, "mlthf_c": -1.0}, "id": "TMDS", "gene_reaction_rule": "ECs3684"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Thiamine kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TMK"]}, "metabolites": {"thm_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "thmmp_c": 1.0}, "id": "TMK", "gene_reaction_rule": "ECs1484"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Thiamine-phosphate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TMPK"]}, "metabolites": {"thmpp_c": 1.0, "atp_c": -1.0, "adp_c": 1.0, "thmmp_c": -1.0}, "id": "TMPK", "gene_reaction_rule": "ECs0470"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Thiamine-phosphate diphosphorylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TMPPP"]}, "metabolites": {"4mpetz_c": -1.0, "ppi_c": 1.0, "h_c": -1.0, "2mahmp_c": -1.0, "thmmp_c": 1.0}, "id": "TMPPP", "gene_reaction_rule": "ECs4916"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Triose-phosphate isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TPI"]}, "metabolites": {"dhap_c": -1.0, "g3p_c": 1.0}, "id": "TPI", "gene_reaction_rule": "ECs4844"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Triphosphoribosyl-dephospho-CoA synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TPRDCOAS"]}, "metabolites": {"2tpr3dpcoa_c": 1.0, "dpcoa_c": -1.0, "ade_c": 1.0, "atp_c": -1.0}, "id": "TPRDCOAS", "gene_reaction_rule": "ECs0652"}, {"subsystem": "Oxidative Phosphorylation", "name": "Thioredoxin reductase (NADPH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRDR"]}, "metabolites": {"trdox_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "trdrd_c": 1.0}, "id": "TRDR", "gene_reaction_rule": "(ECs4714 and ECs0973) or (ECs0973 and ECs3448)"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Trehalose-6-phosphate hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRE6PH"]}, "metabolites": {"tre6p_c": -1.0, "glc__D_c": 1.0, "h2o_c": -1.0, "g6p_c": 1.0}, "id": "TRE6PH", "gene_reaction_rule": "ECs5216"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Trehalose-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRE6PP"]}, "metabolites": {"tre6p_c": -1.0, "tre_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0}, "id": "TRE6PP", "gene_reaction_rule": "ECs2605"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Alpha,alpha-trehalose-phosphate synthase (UDP-forming)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRE6PS"]}, "metabolites": {"tre6p_c": 1.0, "udp_c": 1.0, "udpg_c": -1.0, "g6p_c": -1.0, "h_c": 1.0}, "id": "TRE6PS", "gene_reaction_rule": "ECs2604"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Alpha,alpha-trehalase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TREH"]}, "metabolites": {"glc__D_c": 2.0, "tre_c": -1.0, "h2o_c": -1.0}, "id": "TREH", "gene_reaction_rule": "ECs4399"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Alpha,alpha-trehalase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TREHpp"]}, "metabolites": {"h2o_p": -1.0, "tre_p": -1.0, "glc__D_p": 2.0}, "id": "TREHpp", "gene_reaction_rule": "treA"}, {"subsystem": "Transport, Inner Membrane", "name": "Trehalose transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TREptspp"]}, "metabolites": {"tre6p_c": 1.0, "pep_c": -1.0, "pyr_c": 1.0, "tre_p": 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"metabolites": {"h2o_c": 1.0, "ser__L_c": -1.0, "g3p_c": 1.0, "trp__L_c": 1.0, "3ig3p_c": -1.0}, "id": "TRPS1", "gene_reaction_rule": "ECs1832 and ECs1833"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Tryptophan synthase (indole)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRPS2"]}, "metabolites": {"ser__L_c": -1.0, "h2o_c": 1.0, "trp__L_c": 1.0, "indole_c": -1.0}, "id": "TRPS2", "gene_reaction_rule": "ECs1832 and ECs1833"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Tryptophan synthase (indoleglycerol phosphate)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRPS3"]}, "metabolites": {"3ig3p_c": -1.0, "g3p_c": 1.0, "indole_c": 1.0}, "id": "TRPS3", "gene_reaction_rule": "ECs1832 and ECs1833"}, {"subsystem": "tRNA Charging", "name": "Tryptophanyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRPTRS"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "trnatrp_c": -1.0, "amp_c": 1.0, "trptrna_c": 1.0, "trp__L_c": -1.0}, "id": "TRPTRS", "gene_reaction_rule": "ECs4226"}, {"subsystem": "Transport, Inner Membrane", "name": "L-tryptophan reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TRPt2rpp"]}, "metabolites": {"trp__L_c": 1.0, "trp__L_p": -1.0, "h_p": -1.0, "h_c": 1.0}, "id": "TRPt2rpp", "gene_reaction_rule": "ECs4042 or ECs4646 or ECs2077 or ECs0116"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-tryptophan transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TRPtex"]}, "metabolites": {"trp__L_e": -1.0, "trp__L_p": 1.0}, "id": "TRPtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Tartronate semialdehyde reductase", "upper_bound": 1000.0, 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1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TYRTRS"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "tyrtrna_c": 1.0, "trnatyr_c": -1.0, "amp_c": 1.0, "tyr__L_c": -1.0}, "id": "TYRTRS", "gene_reaction_rule": "ECs2346"}, {"subsystem": "Transport, Inner Membrane", "name": "L-tyrosine reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TYRt2rpp"]}, "metabolites": {"tyr__L_p": -1.0, "h_c": 1.0, "h_p": -1.0, "tyr__L_c": 1.0}, "id": "TYRt2rpp", "gene_reaction_rule": "ECs2077 or ECs2615 or ECs0116 or ECs0614"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-tyrosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TYRtex"]}, "metabolites": {"tyr__L_e": -1.0, "tyr__L_p": 1.0}, "id": "TYRtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Cofactor and Prosthetic Group 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"gene_reaction_rule": "ECs0089"}, {"subsystem": "Alternate Carbon Metabolism", "name": "UDP-N-acetyl-D-galactosamine pyrophosphohydrolase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UACGALPpp"]}, "metabolites": {"h2o_p": -1.0, "ump_p": 1.0, "acgal1p_p": 1.0, "udpacgal_p": -1.0, "h_p": 2.0}, "id": "UACGALPpp", "gene_reaction_rule": "ECs0533"}, {"subsystem": "Alternate Carbon Metabolism", "name": "UDP-N-acetyl-D-glucosamine pyrophosphohydrolase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UACGAMPpp"]}, "metabolites": {"h2o_p": -1.0, "ump_p": 1.0, "uacgam_p": -1.0, "h_p": 2.0, "acgam1p_p": 1.0}, "id": "UACGAMPpp", "gene_reaction_rule": "ECs0533"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "UDP-N-acetyl-D-glucosamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UACGAMtex"]}, "metabolites": {"uacgam_p": 1.0, "uacgam_e": -1.0}, "id": "UACGAMtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetyl-D-mannosamine oxidoreductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UACMAMO"]}, "metabolites": {"uacmam_c": -1.0, "uacmamu_c": 1.0, "h2o_c": -1.0, "h_c": 3.0, "nad_c": -2.0, "nadh_c": 2.0}, "id": "UACMAMO", "gene_reaction_rule": "ECs4720"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylglucosamine 2-epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UAG2E"]}, "metabolites": {"uacgam_c": -1.0, "uacmam_c": 1.0}, "id": "UAG2E", "gene_reaction_rule": "ECs4719"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "UDP-N-acetylglucosamine acyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UAGAAT"]}, "metabolites": {"uacgam_c": -1.0, "u3aga_c": 1.0, "ACP_c": 1.0, "3hmrsACP_c": -1.0}, "id": "UAGAAT", "gene_reaction_rule": "ECs1472 and ECs0183"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylglucosamine 1-carboxyvinyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UAGCVT"]}, "metabolites": {"pep_c": -1.0, "uacgam_c": -1.0, "uaccg_c": 1.0, "pi_c": 1.0}, "id": "UAGCVT", "gene_reaction_rule": "ECs4068"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylglucosamine diphosphorylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UAGDP"]}, "metabolites": {"uacgam_c": 1.0, "utp_c": -1.0, "ppi_c": 1.0, "h_c": -1.0, "acgam1p_c": -1.0}, "id": "UAGDP", "gene_reaction_rule": "ECs4672"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UAGPT3"]}, "metabolites": {"uacgam_c": -1.0, "uaagmda_c": 1.0, "udp_c": 1.0, "uagmda_c": -1.0, "h_c": 1.0}, "id": "UAGPT3", "gene_reaction_rule": "ECs0094"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UAMAGS"]}, "metabolites": {"glu__D_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "uama_c": -1.0, "uamag_c": 1.0}, "id": "UAMAGS", "gene_reaction_rule": "ECs0092"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylmuramoyl-L-alanine synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UAMAS"]}, "metabolites": {"atp_c": -1.0, "uamr_c": -1.0, "ala__L_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "uama_c": 1.0}, "id": "UAMAS", "gene_reaction_rule": "ECs0095"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylenolpyruvoylglucosamine reductase", "upper_bound": 1000.0, 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"notes": {"original_bigg_ids": ["UDCPDPpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "udcpdp_p": -1.0, "udcpp_p": 1.0, "h_p": 1.0}, "id": "UDCPDPpp", "gene_reaction_rule": "ECs1851 or ECs3940 or ECs0921"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Undecaprenyl phosphate transport (cytoplasm to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UDCPPtppi"]}, "metabolites": {"udcpp_p": -1.0, "udcpp_c": 1.0}, "id": "UDCPPtppi", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "UDP-N-acetyl-D-galactosamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UDPACGALtex"]}, "metabolites": {"udpacgal_e": -1.0, "udpacgal_p": 1.0}, "id": "UDPACGALtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Alternate Carbon Metabolism", "name": "UDPglucose 4-epimerase", "upper_bound": 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"upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UDPGPpp"]}, "metabolites": {"h2o_p": -1.0, "ump_p": 1.0, "g1p_p": 1.0, "h_p": 2.0, "udpg_p": -1.0}, "id": "UDPGPpp", "gene_reaction_rule": "ECs0533"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "UDPglucose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UDPGtex"]}, "metabolites": {"udpg_e": -1.0, "udpg_p": 1.0}, "id": "UDPGtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "UDP-4''-ketopentose:UDP-4-amino-4-deoxy-L-arabinose aminotransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UDPKAAT"]}, "metabolites": {"akg_c": 1.0, "glu__L_c": -1.0, "udpLa4o_c": -1.0, "udpLa4n_c": 1.0}, "id": "UDPKAAT", "gene_reaction_rule": "ECs3141"}, {"subsystem": "Alternate Carbon Metabolism", "name": "UDP-D-glucuronate pyrophosphohydrolase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UGLCURPpp"]}, "metabolites": {"h2o_p": -1.0, "ump_p": 1.0, "glcur1p_p": 1.0, "h_p": 2.0, "udpglcur_p": -1.0}, "id": "UGLCURPpp", "gene_reaction_rule": "ECs0533"}, {"subsystem": "Alternate Carbon Metabolism", "name": "UDPglucose--hexose-1-phosphate uridylyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UGLT"]}, "metabolites": {"udpgal_c": 1.0, "udpg_c": -1.0, "gal1p_c": -1.0, "g1p_c": 1.0}, "id": "UGLT", "gene_reaction_rule": "ECs0786"}, {"subsystem": "Nitrogen Metabolism", "name": "Ureidoglycolate hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UGLYCH"]}, "metabolites": {"urdglyc_c": -1.0, "h2o_c": -1.0, "glx_c": 1.0, "h_c": -2.0, "co2_c": 1.0, "nh4_c": 2.0}, "id": "UGLYCH", "gene_reaction_rule": "ECs0566"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UGMDDS"]}, "metabolites": {"atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "ugmda_c": 1.0, "pi_c": 1.0, "alaala_c": -1.0, "ugmd_c": -1.0}, "id": "UGMDDS", "gene_reaction_rule": "ECs0090"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "UDP-3-O-acetylglucosamine deacetylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UHGADA"]}, "metabolites": {"u3aga_c": -1.0, "u3hga_c": 1.0, "h2o_c": -1.0, "ac_c": 1.0}, "id": "UHGADA", "gene_reaction_rule": "ECs0100"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "UDP-L-Ara4N formyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ULA4NFT"]}, "metabolites": {"h_c": 1.0, "udpLa4fn_c": 1.0, "udpLa4n_c": -1.0, "thf_c": 1.0, "10fthf_c": -1.0}, "id": "ULA4NFT", 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"id": "UREAtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Inner Membrane", "name": "Urea transport via facilitate diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UREAtpp"]}, "metabolites": {"urea_p": -1.0, "urea_c": 1.0}, "id": "UREAtpp", "gene_reaction_rule": "ECs4852"}, {"subsystem": "Unassigned", "name": "Uricase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["URIC"]}, "metabolites": {"o2_c": -1.0, "h2o_c": -2.0, "urate_c": -1.0, "h2o2_c": 1.0, "co2_c": 1.0, "alltn_c": 1.0}, "id": "URIC", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Uridine hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["URIH"]}, "metabolites": {"uri_c": -1.0, "h2o_c": -1.0, "rib__D_c": 1.0, "ura_c": 1.0}, "id": "URIH", "gene_reaction_rule": "ECs3054 or ECs0690 or ECs0033"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Uridine kinase (GTP:Uridine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["URIK2"]}, "metabolites": {"gtp_c": -1.0, "gdp_c": 1.0, "h_c": 1.0, "ump_c": 1.0, "uri_c": -1.0}, "id": "URIK2", "gene_reaction_rule": "ECs2873"}, {"subsystem": "Transport, Inner Membrane", "name": "Uridine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["URIt2pp", "URIt2rpp"]}, "metabolites": {"uri_c": 1.0, "uri_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "URIt2pp_copy1", "gene_reaction_rule": "ECs3272 or ECs3840"}, {"subsystem": "Transport, Outer Membrane", "name": "Uridine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["URItex"]}, "metabolites": {"uri_p": 1.0, "uri_e": -1.0}, "id": "URItex", "gene_reaction_rule": "ECs0464"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "UDP-sugar hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["USHD"]}, "metabolites": {"u23ga_c": -1.0, "h2o_c": -1.0, "h_c": 2.0, "lipidX_c": 1.0, "ump_c": 1.0}, "id": "USHD", "gene_reaction_rule": "ECs0586"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Valine transaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["VALTA"]}, "metabolites": {"akg_c": -1.0, "glu__L_c": 1.0, "val__L_c": -1.0, "3mob_c": 1.0}, "id": "VALTA", "gene_reaction_rule": "ECs4704"}, {"subsystem": "tRNA Charging", "name": "Valyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["VALTRS"]}, "metabolites": {"valtrna_c": 1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "trnaval_c": -1.0, "val__L_c": -1.0}, "id": "VALTRS", "gene_reaction_rule": "ECs5235"}, {"subsystem": "Transport, Inner Membrane", "name": "L-valine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["VALabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "val__L_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "val__L_c": 1.0}, "id": "VALabcpp", "gene_reaction_rule": "ECs4301 and ECs4302 and ECs4304 and ECs4309 and ECs4303"}, {"subsystem": "Transport, Inner Membrane", "name": "L-valine reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["VALt2rpp"]}, "metabolites": {"val__L_p": -1.0, "h_c": 1.0, "h_p": -1.0, "val__L_c": 1.0}, "id": "VALt2rpp", "gene_reaction_rule": "ECs0451 or (ECs3545 and ECs3544)"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-valine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["VALtex"]}, "metabolites": {"val__L_e": -1.0, "val__L_p": 1.0}, "id": "VALtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Valine-pyruvate aminotransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["VPAMTr", "VPAMT"]}, "metabolites": {"pyr_c": 1.0, "val__L_c": 1.0, "ala__L_c": -1.0, "3mob_c": -1.0}, "id": "VPAMTr_copy1", "gene_reaction_rule": "ECs4455"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Tungsten pterin cofactor synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["WCOS"]}, "metabolites": {"cu2_c": 1.0, "h2o_c": 1.0, "h_c": -2.0, "tungs_c": -1.0, "amp_c": 1.0, "wco_c": 1.0, "mptamp_c": -1.0}, "id": "WCOS", "gene_reaction_rule": "ECs0905"}, {"subsystem": "Alternate Carbon Metabolism", "name": "L-xylulose 5-phosphate 3-epimerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["X5PL3E"]}, "metabolites": {"xu5p__L_c": -1.0, "ru5p__L_c": 1.0}, "id": "X5PL3E", "gene_reaction_rule": "ECs5173"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Xanthine dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["XAND"]}, "metabolites": {"h2o_c": -1.0, "xan_c": -1.0, "urate_c": 1.0, "h_c": 1.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "XAND", "gene_reaction_rule": "ECs3739 and ECs3740 and ECs3741"}, {"subsystem": "Transport, Inner Membrane", "name": "Xanthine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["XANt2pp"]}, "metabolites": {"h_c": 1.0, "xan_c": 1.0, "h_p": -1.0, "xan_p": -1.0}, "id": "XANt2pp", "gene_reaction_rule": "ECs4530 or ECs3755"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Xanthine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XANtex"]}, "metabolites": {"xan_e": -1.0, "xan_p": 1.0}, "id": "XANtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Transport, Inner Membrane", "name": "Xanthine reversible transport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XANtpp"]}, "metabolites": {"xan_p": -1.0, "xan_c": 1.0}, "id": "XANtpp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "XMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XMPtex"]}, "metabolites": {"xmp_p": 1.0, "xmp_e": -1.0}, "id": "XMPtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Xanthine phosphoribosyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["XPPT"]}, "metabolites": {"xmp_c": 1.0, "ppi_c": 1.0, "prpp_c": -1.0, "xan_c": -1.0}, "id": "XPPT", "gene_reaction_rule": "ECs0265"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Xanthosine hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["XTSNH"]}, "metabolites": {"h2o_c": -1.0, "rib__D_c": 1.0, "xan_c": 1.0, "xtsn_c": -1.0}, "id": "XTSNH", "gene_reaction_rule": "ECs0033"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Xanthosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XTSNtex"]}, "metabolites": {"xtsn_e": -1.0, "xtsn_p": 1.0}, "id": "XTSNtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Xylose isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XYLI1"]}, "metabolites": {"xylu__D_c": 1.0, "xyl__D_c": -1.0}, "id": "XYLI1", "gene_reaction_rule": "ECs4448"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Xylose isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XYLI2"]}, "metabolites": {"glc__D_c": -1.0, "fru_c": 1.0}, "id": "XYLI2", "gene_reaction_rule": "ECs4448"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Xylulokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["XYLK"]}, "metabolites": {"xylu__D_c": -1.0, "xu5p__D_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "XYLK", "gene_reaction_rule": "ECs0067 or ECs4447"}, {"subsystem": "Alternate Carbon Metabolism", "name": "L-xylulokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["XYLK2"]}, "metabolites": {"xylu__L_c": -1.0, "xu5p__L_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "XYLK2", "gene_reaction_rule": "ECs0067"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-xylulose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XYLUtex"]}, "metabolites": {"xylu__L_p": 1.0, "xylu__L_e": -1.0}, "id": "XYLUtex", "gene_reaction_rule": "ECs0268 or 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1.0}, "id": "XYLtex", "gene_reaction_rule": "ECs0268 or ECs1012 or ompN or ECs3104"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Zinc (Zn+2) ABC transporter, efflux (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ZN2abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "zn2_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "zn2_c": -1.0}, "id": "ZN2abcpp", "gene_reaction_rule": "ECs4318"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Zinc (Zn+2) transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ZN2t3pp"]}, "metabolites": {"h_p": -1.0, "h_c": 1.0, "zn2_p": 1.0, "zn2_c": -1.0}, "id": "ZN2t3pp", "gene_reaction_rule": "ECs4840 or ECs0780"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Zinc transport in via permease (no H+)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ZN2tpp"]}, 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{"tartr__L_p": -1.0, "tartr__L_c": 1.0}, "id": "TARTRtpp", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "4 Aminobenzoate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_4abz_LPAREN_e_RPAREN_"]}, "metabolites": {"4abz_e": -1.0}, "id": "EX_4abz_e", "gene_reaction_rule": ""}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxooctanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HACD3i"]}, "metabolites": {"nad_c": -1.0, "nadh_c": 1.0, "h_c": 1.0, "3oocoa_c": 1.0, "3hocoa_c": -1.0}, "id": "HACD3i", "gene_reaction_rule": "ECs3224 or ECs4774"}, {"subsystem": "Transport Outer Membrane Porin", "name": "3 Phospho D glycerate transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["3PGtex"]}, "metabolites": {"3pg_e": -1.0, "3pg_p": 1.0}, "id": "3PGtex", "gene_reaction_rule": "ECs0268 or 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{"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxohexanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HACD2i"]}, "metabolites": {"3hhcoa_c": -1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0, "3ohcoa_c": 1.0}, "id": "HACD2i", "gene_reaction_rule": "ECs4774 or ECs3224"}, {"subsystem": "Exchange", "name": "Ferrioxamine B exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_feroxB_LPAREN_e_RPAREN_"]}, "metabolites": {"feroxB_e": -1.0}, "id": "EX_feroxB_e", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Biotin sulfoxide reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["BSORx"]}, "metabolites": {"h2o_c": 1.0, "btn_c": 1.0, "btnso_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "nadh_c": -1.0}, "id": "BSORx", "gene_reaction_rule": "ECs4436"}, {"subsystem": "Exchange", "name": "Trithionate Exchange", 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"ECs2442 and ECs2444 and ECs2443 and ECs3287 and ECs3288"}, {"subsystem": "Exchange", "name": "Ferrioxamine E fe exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_feroxEfe_LPAREN_e_RPAREN_"]}, "metabolites": {"feroxEfe_e": -1.0}, "id": "EX_feroxEfe_e", "gene_reaction_rule": ""}, {"subsystem": "Transport Inner Membrane", "name": "Aminoimidazole riboside facilitated transport periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AIRStpp"]}, "metabolites": {"airs_p": -1.0, "airs_c": 1.0}, "id": "AIRStpp", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "Ferrioxamine E exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_feroxE_LPAREN_e_RPAREN_"]}, "metabolites": {"feroxE_e": -1.0}, "id": "EX_feroxE_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "O-acetyl-L-serine sulfhydrylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SLCYSS"]}, "metabolites": {"ac_c": 1.0, "acser_c": -1.0, "tsul_c": -1.0, "slcys_c": 1.0}, "id": "SLCYSS", "gene_reaction_rule": "ECs3292"}, {"subsystem": "Exchange", "name": "Phosphoenolpyruvate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_pep_LPAREN_e_RPAREN_"]}, "metabolites": {"pep_e": -1.0}, "id": "EX_pep_e", "gene_reaction_rule": ""}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxododecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HACD5i"]}, "metabolites": {"3oddcoa_c": 1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0, "3hddcoa_c": -1.0}, "id": "HACD5i", "gene_reaction_rule": "ECs4774 or ECs3224"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Salmochelin SX via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["SALCHSXtex"]}, "metabolites": 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"Alternate Carbon Metabolism", "name": "Chitobiose-6-phosphate hydrolase", "upper_bound": 0.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHITPH"]}, "metabolites": {"acgam_c": 1.0, "h2o_c": -1.0, "acgam6p_c": 1.0, "chit6p_c": -1.0}, "id": "CHITPH", "gene_reaction_rule": "ECs2440"}, {"subsystem": "Transport Inner Membrane", "name": "L cystine uptake via ABC system periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CYSIabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "cysi__L_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "cysi__L_p": -1.0, "pi_c": 1.0}, "id": "CYSIabcpp", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "D Tagatose exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_tag_D_LPAREN_e_RPAREN_"]}, "metabolites": {"tag__D_e": -1.0}, "id": "EX_tag__D_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "Oxaloacetate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, 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"EX_salchs2fe_e", "gene_reaction_rule": ""}, {"subsystem": "Transport", "name": "L-gulonate transport", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GULNLtex"]}, "metabolites": {"guln__L_e": -1.0, "guln__L_p": 1.0}, "id": "GULNLtex", "gene_reaction_rule": "ECs0268 or ompN or ECs3104"}, {"subsystem": "Histidine metabolism", "name": "Urocanate hydratase", "upper_bound": 0.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UROCANH"]}, "metabolites": {"4iz5pp_c": 1.0, "h2o_c": -1.0, "urocan_c": -1.0}, "id": "UROCANH", "gene_reaction_rule": ""}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxodecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HACD4i"]}, "metabolites": {"3odcoa_c": 1.0, "3hdcoa_c": -1.0, "h_c": 1.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "HACD4i", "gene_reaction_rule": "ECs4774 or ECs3224"}, {"subsystem": "Exchange", "name": "L Cystine exchange", 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"gene_reaction_rule": "ECs3230"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Salmochelin s2 Fe III sequestration", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SALCHS2FEexs"]}, "metabolites": {"salchs2fe_e": 1.0, "salchs2_e": -1.0, "fe3_e": -1.0}, "id": "SALCHS2FEexs", "gene_reaction_rule": "s0001"}, {"subsystem": "Exchange", "name": "Deoxy D Ribose exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_drib_LPAREN_e_RPAREN_"]}, "metabolites": {"drib_e": -1.0}, "id": "EX_drib_e", "gene_reaction_rule": ""}, {"subsystem": "Transport, Inner Membrane", "name": "4-hydroxy-L-threonine transport", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["4HTHRtrpp"]}, "metabolites": {"4hthr_p": -1.0, "h_c": 1.0, "h_p": -1.0, "4hthr_c": 1.0}, "id": "4HTHRtrpp", "gene_reaction_rule": "ECs3996"}, {"subsystem": "Transport", "name": "Myo-inositol transport", "upper_bound": 1000.0, 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and ECs4849)"}, {"subsystem": "Exchange", "name": "Glutathione peridoxase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GTHPi", "GSHPO"]}, "metabolites": {"h2o2_c": -1.0, "h2o_c": 2.0, "gthrd_c": -2.0, "gthox_c": 1.0}, "id": "GTHPi_copy2", "gene_reaction_rule": "ECs2417"}, {"subsystem": "Methionine Metabolism", "name": "4,5-dihydroxy-2,3-pentanedione cyclization (spontaneous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPTDCs"]}, "metabolites": {"h2o_c": 1.0, "hmfurn_c": 1.0, "dhptd_c": -1.0}, "id": "DHPTDCs", "gene_reaction_rule": "s0001"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Undecaprenyl phosphate 4-amino-4-deoxy L-arabinose synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UPLA4NT"]}, "metabolites": {"udp_c": 1.0, "uLa4n_c": 1.0, "udpLa4n_c": -1.0, "udcpp_c": -1.0}, "id": "UPLA4NT", "gene_reaction_rule": "ECs3142"}, {"subsystem": "Exchange", "name": "Formamide exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_foam_LPAREN_e_RPAREN_"]}, "metabolites": {"foam_e": -1.0}, "id": "EX_foam_e", "gene_reaction_rule": ""}, {"subsystem": "Transport", "name": "Tricarballylate transport into periplasm", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TCBt2ex"]}, "metabolites": {"tcb_p": 1.0, "tcb_e": -1.0}, "id": "TCBt2ex", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "Membrane LPS mixture Exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_colipaOA_LPAREN_e_RPAREN_"]}, "metabolites": {"colipaOA_e": -1.0}, "id": "EX_colipaOA_e", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Salmochelin s1 hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SALCHS1H"]}, "metabolites": {"h2o_c": -1.0, "salchsx_c": 1.0, "salchs1_c": -1.0, "23dhbzs_c": 1.0}, "id": "SALCHS1H", 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"metabolites": {"icit_e": -1.0}, "id": "EX_icit_e", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "Oxaloacetate transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["OAAtex"]}, "metabolites": {"oaa_e": -1.0, "oaa_p": 1.0}, "id": "OAAtex", "gene_reaction_rule": "ompN or ECs0268 or ECs3104"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "4-Hydroxy-L-threonine kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["4HTHRK"]}, "metabolites": {"phthr_c": 1.0, "4hthr_c": -1.0, "atp_c": -1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "4HTHRK", "gene_reaction_rule": "ECs0003"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Tetrathionate transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TETtex"]}, "metabolites": {"tet_p": 1.0, "tet_e": -1.0}, "id": "TETtex", "gene_reaction_rule": "ECs0268 or ompN or ECs3104"}, {"subsystem": "Translation", "name": "Pseudouridylate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PSUDS"]}, "metabolites": {"ura_c": -1.0, "r5p_c": -1.0, "psd5p_c": 1.0, "h_c": -2.0, "h2o_c": 1.0}, "id": "PSUDS", "gene_reaction_rule": "ECs3457"}, {"subsystem": "Exchange", "name": "O antigen x20 core oligosaccharide lipid A exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_colipa20Oag_LPAREN_e_RPAREN_"]}, "metabolites": {"colipa20Oag_e": -1.0}, "id": "EX_colipa20Oag_e", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-dehydro-3-deoxy-6-phosphogalactonate aldolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DDPGALA"]}, "metabolites": {"2dh3dgal6p_c": -1.0, "pyr_c": 1.0, "g3p_c": 1.0}, "id": "DDPGALA", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Enterobactin hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ENTERH"]}, "metabolites": {"h2o_c": -1.0, "23dhbzs3_c": 1.0, "enter_c": -1.0}, "id": "ENTERH", "gene_reaction_rule": "iroD or ECs0624"}, {"subsystem": "Exchange", "name": "Residual atoms of reaction DMBZIDSYN exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_remnant1_LPAREN_e_RPAREN_"]}, "metabolites": {"remnant1_e": -1.0}, "id": "EX_remnant1_e", "gene_reaction_rule": ""}, {"subsystem": "Cysteine Metabolism", "name": "S-sulfo-L-cysteine sulfite lyase ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SCYSSL"]}, "metabolites": {"cys__L_c": 1.0, "so3_c": 1.0, "slcys_c": -1.0, "h_c": 1.0, "gthrd_c": -2.0, "gthox_c": 1.0}, "id": "SCYSSL", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "D Tagatose transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TAGtex"]}, "metabolites": {"tag__D_p": 1.0, "tag__D_e": -1.0}, "id": "TAGtex", "gene_reaction_rule": "ECs0268 or ompN or ECs3104"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Nmn hydrolysis", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NMNR"]}, "metabolites": {"h2o_e": -1.0, "nmn_e": -1.0, "rnam_e": 1.0, "pi_e": 1.0}, "id": "NMNR", "gene_reaction_rule": "ECs3620"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Purine-nucleoside phosphorylase (Xanthosine)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PUNP7"]}, "metabolites": {"pi_c": -1.0, "r1p_c": 1.0, "xan_c": 1.0, "xtsn_c": -1.0}, "id": "PUNP7", "gene_reaction_rule": "xapA"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Cisaconitat transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACONCtex"]}, "metabolites": {"acon_C_e": -1.0, "acon_C_p": 1.0}, "id": "ACONCtex", "gene_reaction_rule": "ECs0268 or ompN or ECs3104"}, {"subsystem": "Exchange", "name": "Ferrioxamine G fe exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_feroxGfe_LPAREN_e_RPAREN_"]}, "metabolites": {"feroxGfe_e": -1.0}, "id": "EX_feroxGfe_e", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Adenosylcobalamin phosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ADOCBLPS"]}, "metabolites": {"5prdmbz_c": -1.0, "gmp_c": 1.0, "h_c": 1.0, "adocblp_c": 1.0, "agdpcbi_c": -1.0}, "id": "ADOCBLPS", "gene_reaction_rule": "ECs2787"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Salmochelin s2 Fe III reduction and offloading", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SALCHS2FER1"]}, "metabolites": {"fe2_c": 2.0, "salchs2_c": 2.0, "fadh2_c": -1.0, "salchs2fe_c": -2.0, "h_c": 2.0, "fad_c": 1.0}, "id": "SALCHS2FER1", "gene_reaction_rule": "iroD"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Salmochelin s2 Fe III reduction and offloading", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SALCHS2FER2"]}, "metabolites": {"fe2_c": 2.0, "salchs2_c": 2.0, "fmnh2_c": -1.0, "fmn_c": 1.0, "h_c": 2.0, "salchs2fe_c": -2.0}, "id": "SALCHS2FER2", "gene_reaction_rule": "iroD"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Salmochelin s2 Fe III reduction and offloading", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SALCHS2FER3"]}, "metabolites": {"rbflvrd_c": -1.0, "fe2_c": 2.0, "salchs2_c": 2.0, "salchs2fe_c": -2.0, "h_c": 2.0, "ribflv_c": 1.0}, "id": "SALCHS2FER3", "gene_reaction_rule": "iroD"}, {"subsystem": "Exchange", "name": "Salmochelin-S2 Exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_salchs2_LPAREN_e_RPAREN_"]}, "metabolites": {"salchs2_e": -1.0}, "id": "EX_salchs2_e", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Sirohydrochlorin cobaltochelatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DSCLCOCH"]}, "metabolites": {"dscl_c": -1.0, "codscl2_c": 1.0, "cobalt2_c": -1.0, "h_c": 2.0}, "id": "DSCLCOCH", "gene_reaction_rule": "ECs4219"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Aminoimidazole riboside transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AIRStex"]}, "metabolites": {"airs_p": 1.0, "airs_e": -1.0}, "id": "AIRStex", "gene_reaction_rule": "ECs0268 or ompN or ECs3104"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-cis-2-trans-enoyl-CoA isomerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CTECOAI8", "ODECOAI"]}, "metabolites": {"od2coa_c": 1.0, "odecoa_c": -1.0}, "id": "CTECOAI8_copy2", "gene_reaction_rule": "ECs4774"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HACD1i"]}, "metabolites": {"aacoa_c": 1.0, "3hbcoa_c": -1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "HACD1i", "gene_reaction_rule": "ECs4774 or ECs3224"}, {"subsystem": "Exchange", "name": "N-Ribosylnicotinamide Exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_rnam_LPAREN_e_RPAREN_"]}, "metabolites": {"rnam_e": -1.0}, "id": "EX_rnam_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "Aminoimidazole riboside exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_airs_LPAREN_e_RPAREN_"]}, "metabolites": {"airs_e": -1.0}, "id": "EX_airs_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "1-deoxy-D-xylulose Exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_dxyl_LPAREN_e_RPAREN_"]}, "metabolites": {"dxyl_e": -1.0}, "id": "EX_dxyl_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "3 Phospho D glycerate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_3pg_LPAREN_e_RPAREN_"]}, "metabolites": {"3pg_e": -1.0}, "id": "EX_3pg_e", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Ribosylnicotinamide kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["RNMK"]}, "metabolites": {"rnam_c": -1.0, "nmn_c": 1.0, "atp_c": -1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "RNMK", "gene_reaction_rule": "ECs5348"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Uridylate kinase (dUMP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["URIDK2r"]}, "metabolites": {"dump_c": -1.0, "atp_c": -1.0, "adp_c": 1.0, "dudp_c": 1.0}, "id": "URIDK2r", "gene_reaction_rule": "ECs0173"}, {"subsystem": "Glutamate metabolism", "name": "Glutamate synthase (NADPH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUSy"]}, "metabolites": {"akg_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "glu__L_c": 2.0, "h_c": -1.0, "gln__L_c": -1.0}, "id": "GLUSy", "gene_reaction_rule": "ECs4091 and ECs4092"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "Valine-pyruvate aminotransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["VPAMTr", "VPAMT"]}, "metabolites": {"pyr_c": 1.0, "val__L_c": 1.0, "ala__L_c": -1.0, "3mob_c": -1.0}, "id": "VPAMTr_copy2", "gene_reaction_rule": "ECs4455"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxooctadecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HACD8i"]}, "metabolites": {"3hodcoa_c": -1.0, "3oodcoa_c": 1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "HACD8i", "gene_reaction_rule": "ECs4774 or ECs3224"}, {"subsystem": "Transport Outer Membrane Porin", "name": "D Glycerate 2 phosphate transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["2PGtex"]}, "metabolites": {"2pg_e": -1.0, "2pg_p": 1.0}, "id": "2PGtex", "gene_reaction_rule": "ECs0268 or ompN or ECs3104"}, {"subsystem": "Exchange", "name": "Undecaprenyl diphosphate galactose-rhamnose-mannose-abequose Exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_udcpo4_LPAREN_e_RPAREN_"]}, "metabolites": {"udcpo4_e": -1.0}, "id": "EX_udcpo4_e", "gene_reaction_rule": ""}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxotetradecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HACD6i"]}, "metabolites": {"3otdcoa_c": 1.0, 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"Oxaloacetate transport via proton symport 2 H  periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OAAt2_2pp"]}, "metabolites": {"h_c": 2.0, "h_p": -2.0, "oaa_c": 1.0, "oaa_p": -1.0}, "id": "OAAt2_2pp", "gene_reaction_rule": "ECs4408"}, {"subsystem": "Exchange", "name": "Undecaprenyl diphosphate galactose-rhamnose-mannose-abequose-acetyl Exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_udcpo5_LPAREN_e_RPAREN_"]}, "metabolites": {"udcpo5_e": -1.0}, "id": "EX_udcpo5_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "L-gulonate Exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_guln_L_LPAREN_e_RPAREN_"]}, "metabolites": {"guln__L_e": -1.0}, "id": "EX_guln__L_e", "gene_reaction_rule": ""}, {"subsystem": "Pyruvate Metabolism", "name": "Pyruvate flavodoxin oxidoreductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PFOR"]}, 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{"notes": {"original_bigg_ids": ["ECs4078"]}, "name": "ECs4078", "id": "ECs4078"}, {"notes": {"original_bigg_ids": ["ECs5238"]}, "name": "ECs5238", "id": "ECs5238"}, {"notes": {"original_bigg_ids": ["ECs4080"]}, "name": "ECs4080", "id": "ECs4080"}, {"notes": {"original_bigg_ids": ["ECs2126"]}, "name": "ECs2126", "id": "ECs2126"}, {"notes": {"original_bigg_ids": ["ECs0122"]}, "name": "ECs0122", "id": "ECs0122"}, {"notes": {"original_bigg_ids": ["ECs1849"]}, "name": "ECs1849", "id": "ECs1849"}, {"notes": {"original_bigg_ids": ["ECs4210"]}, "name": "ECs4210", "id": "ECs4210"}, {"notes": {"original_bigg_ids": ["ECs2454"]}, "name": "ECs2454", "id": "ECs2454"}, {"notes": {"original_bigg_ids": ["ECs1468"]}, "name": "ECs1468", "id": "ECs1468"}, {"notes": {"original_bigg_ids": ["ECs4342"]}, "name": "ECs4342", "id": "ECs4342"}, {"notes": {"original_bigg_ids": ["ECs3429"]}, "name": "ECs3429", "id": "ECs3429"}, {"notes": {"original_bigg_ids": ["ECs3444"]}, "name": "ECs3444", "id": "ECs3444"}, {"notes": {"original_bigg_ids": ["ECs2140"]}, "name": "ECs2140", "id": "ECs2140"}, {"notes": {"original_bigg_ids": ["ECs5049"]}, "name": "ECs5049", "id": "ECs5049"}, {"notes": {"original_bigg_ids": ["ECs2331"]}, "name": "ECs2331", "id": "ECs2331"}, {"notes": {"original_bigg_ids": ["ECs1474"]}, "name": "ECs1474", "id": "ECs1474"}, {"notes": {"original_bigg_ids": ["ECs4211"]}, "name": "ECs4211", "id": "ECs4211"}, {"notes": {"original_bigg_ids": ["ECs2521"]}, "name": "ECs2521", "id": "ECs2521"}, {"notes": {"original_bigg_ids": ["ECs4602"]}, "name": "ECs4602", "id": "ECs4602"}, {"notes": {"original_bigg_ids": ["ECs4651"]}, "name": "ECs4651", "id": "ECs4651"}, {"notes": {"original_bigg_ids": ["ECs4530"]}, "name": "ECs4530", "id": "ECs4530"}, {"notes": {"original_bigg_ids": ["ECs0527"]}, "name": "ECs0527", "id": "ECs0527"}, {"notes": {"original_bigg_ids": ["ECs0124"]}, "name": "ECs0124", "id": "ECs0124"}, {"notes": {"original_bigg_ids": ["ECs4736"]}, "name": "ECs4736", "id": "ECs4736"}, {"notes": {"original_bigg_ids": ["ECs0033"]}, "name": "ECs0033", "id": "ECs0033"}, {"notes": {"original_bigg_ids": ["ECs3840"]}, "name": "ECs3840", "id": "ECs3840"}, {"notes": {"original_bigg_ids": ["ECs3272"]}, "name": "ECs3272", "id": "ECs3272"}, {"notes": {"original_bigg_ids": ["ECs0464"]}, "name": "ECs0464", "id": "ECs0464"}, {"notes": {"original_bigg_ids": ["ECs2787"]}, "name": "ECs2787", "id": "ECs2787"}, {"notes": {"original_bigg_ids": ["ECs0162"]}, "name": "ECs0162", "id": "ECs0162"}, {"notes": {"original_bigg_ids": ["ECs2418"]}, "name": "ECs2418", "id": "ECs2418"}, {"notes": {"original_bigg_ids": ["ECs2416"]}, "name": "ECs2416", "id": "ECs2416"}, {"notes": {"original_bigg_ids": ["ECs3890"]}, "name": "ECs3890", "id": "ECs3890"}, {"notes": {"original_bigg_ids": ["ECs3889"]}, "name": "ECs3889", "id": "ECs3889"}, {"notes": {"original_bigg_ids": ["ECs4897"]}, "name": "ECs4897", "id": "ECs4897"}, {"notes": {"original_bigg_ids": ["ECs1752"]}, "name": "ECs1752", "id": "ECs1752"}, {"notes": {"original_bigg_ids": ["ECs3922"]}, "name": "ECs3922", "id": "ECs3922"}, {"notes": {"original_bigg_ids": ["ECs4239"]}, "name": "ECs4239", "id": "ECs4239"}, {"notes": {"original_bigg_ids": ["ECs0522"]}, "name": "ECs0522", "id": "ECs0522"}, {"notes": {"original_bigg_ids": ["ECs3604"]}, "name": "ECs3604", "id": "ECs3604"}, {"notes": {"original_bigg_ids": ["ECs1603"]}, "name": "ECs1603", "id": "ECs1603"}, {"notes": {"original_bigg_ids": ["ECs5153"]}, "name": "ECs5153", "id": "ECs5153"}, {"notes": {"original_bigg_ids": ["ECs0707"]}, "name": "ECs0707", "id": "ECs0707"}, {"notes": {"original_bigg_ids": ["ECs0114"]}, "name": "ECs0114", "id": "ECs0114"}, {"notes": {"original_bigg_ids": ["ECs5145"]}, "name": "ECs5145", "id": "ECs5145"}, {"notes": {"original_bigg_ids": ["ECs3306"]}, "name": "ECs3306", "id": "ECs3306"}, {"notes": {"original_bigg_ids": ["ECs3674"]}, "name": "ECs3674", "id": "ECs3674"}, {"notes": {"original_bigg_ids": ["ECs1485"]}, "name": "ECs1485", "id": "ECs1485"}, {"notes": {"original_bigg_ids": ["ECs0487"]}, "name": "ECs0487", "id": "ECs0487"}, {"notes": {"original_bigg_ids": ["ECs4497"]}, "name": "ECs4497", "id": "ECs4497"}, {"notes": {"original_bigg_ids": ["ECs3812"]}, "name": "ECs3812", "id": "ECs3812"}, {"notes": {"original_bigg_ids": ["ECs3902"]}, "name": "ECs3902", "id": "ECs3902"}, {"notes": {"original_bigg_ids": ["ECs4887"]}, "name": "ECs4887", "id": "ECs4887"}, {"notes": {"original_bigg_ids": ["ECs0611"]}, "name": "ECs0611", "id": "ECs0611"}, {"notes": {"original_bigg_ids": ["ECs0610"]}, "name": "ECs0610", "id": "ECs0610"}, {"notes": {"original_bigg_ids": ["ECs0612"]}, "name": "ECs0612", "id": "ECs0612"}, {"notes": {"original_bigg_ids": ["ECs0613"]}, "name": "ECs0613", "id": "ECs0613"}, {"notes": {"original_bigg_ids": ["ECs4929"]}, "name": "ECs4929", "id": "ECs4929"}, {"notes": {"original_bigg_ids": ["ECs0584"]}, "name": "ECs0584", "id": "ECs0584"}, {"notes": {"original_bigg_ids": ["ECs0585"]}, "name": "ECs0585", "id": "ECs0585"}, {"notes": {"original_bigg_ids": ["ECs0120"]}, "name": "ECs0120", "id": "ECs0120"}, {"notes": {"original_bigg_ids": ["ECs0751"]}, "name": "ECs0751", "id": "ECs0751"}, {"notes": {"original_bigg_ids": ["ECs0752"]}, "name": "ECs0752", "id": "ECs0752"}, {"notes": {"original_bigg_ids": ["ECs3454"]}, "name": "ECs3454", "id": "ECs3454"}, {"notes": {"original_bigg_ids": ["ECs2092"]}, "name": "ECs2092", "id": "ECs2092"}, {"notes": {"original_bigg_ids": ["ECs4423"]}, "name": "ECs4423", "id": "ECs4423"}, {"notes": {"original_bigg_ids": ["ECs2091"]}, "name": "ECs2091", "id": "ECs2091"}, {"notes": {"original_bigg_ids": ["ECs2087"]}, "name": "ECs2087", "id": "ECs2087"}, {"notes": {"original_bigg_ids": ["ECs2088"]}, "name": "ECs2088", "id": "ECs2088"}, {"notes": {"original_bigg_ids": ["ECs4420"]}, "name": "ECs4420", "id": "ECs4420"}, {"notes": {"original_bigg_ids": ["ECs4424"]}, "name": "ECs4424", "id": "ECs4424"}, {"notes": {"original_bigg_ids": ["ECs2090"]}, "name": "ECs2090", "id": "ECs2090"}, {"notes": {"original_bigg_ids": ["ECs2089"]}, "name": "ECs2089", "id": "ECs2089"}, {"notes": {"original_bigg_ids": ["ECs4422"]}, "name": "ECs4422", "id": "ECs4422"}, {"notes": {"original_bigg_ids": ["ECs4421"]}, "name": "ECs4421", "id": "ECs4421"}, {"notes": {"original_bigg_ids": ["ECs0096"]}, "name": "ECs0096", "id": "ECs0096"}, {"notes": {"original_bigg_ids": ["ECs0431"]}, "name": "ECs0431", "id": "ECs0431"}, {"notes": {"original_bigg_ids": ["ECs1904"]}, "name": "ECs1904", "id": "ECs1904"}, {"notes": {"original_bigg_ids": ["ECs1685"]}, "name": "ECs1685", "id": "ECs1685"}, {"notes": {"original_bigg_ids": ["ECs5035"]}, "name": "ECs5035", "id": "ECs5035"}, {"notes": {"original_bigg_ids": ["ECs3417"]}, "name": "ECs3417", "id": "ECs3417"}, {"notes": {"original_bigg_ids": ["ECs0956"]}, "name": "ECs0956", "id": "ECs0956"}, {"notes": {"original_bigg_ids": ["ECs3174"]}, "name": "ECs3174", "id": "ECs3174"}, {"notes": {"original_bigg_ids": ["ECs3259"]}, "name": "ECs3259", "id": "ECs3259"}, {"notes": {"original_bigg_ids": ["ECs3554"]}, "name": "ECs3554", "id": "ECs3554"}, {"notes": {"original_bigg_ids": ["ECs4303"]}, "name": "ECs4303", "id": "ECs4303"}, {"notes": {"original_bigg_ids": ["ECs4309"]}, "name": "ECs4309", "id": "ECs4309"}, {"notes": {"original_bigg_ids": ["ECs4301"]}, "name": "ECs4301", "id": "ECs4301"}, {"notes": {"original_bigg_ids": ["ECs4304"]}, "name": "ECs4304", "id": "ECs4304"}, {"notes": {"original_bigg_ids": ["ECs4302"]}, "name": "ECs4302", "id": "ECs4302"}, {"notes": {"original_bigg_ids": ["ECs5186"]}, "name": "ECs5186", "id": "ECs5186"}, {"notes": {"original_bigg_ids": ["ECs0007"]}, "name": "ECs0007", "id": "ECs0007"}, {"notes": {"original_bigg_ids": ["ECs0411"]}, "name": "ECs0411", "id": "ECs0411"}, {"notes": {"original_bigg_ids": ["ECs2082"]}, "name": "ECs2082", "id": "ECs2082"}, {"notes": {"original_bigg_ids": ["ECs1877"]}, "name": "ECs1877", "id": "ECs1877"}, {"notes": {"original_bigg_ids": ["ECs4464"]}, "name": "ECs4464", "id": "ECs4464"}, {"notes": {"original_bigg_ids": ["ECs0578"]}, "name": "ECs0578", "id": "ECs0578"}, {"notes": {"original_bigg_ids": ["allB"]}, "name": "None", "id": "allB"}, {"notes": {"original_bigg_ids": ["ECs0572"]}, "name": "ECs0572", "id": "ECs0572"}, {"notes": {"original_bigg_ids": ["ECs2384"]}, "name": "ECs2384", "id": "ECs2384"}, {"notes": {"original_bigg_ids": ["ECs0695"]}, "name": "ECs0695", "id": "ECs0695"}, {"notes": {"original_bigg_ids": ["ECs3896"]}, "name": "ECs3896", "id": "ECs3896"}, {"notes": {"original_bigg_ids": ["ECs3885"]}, "name": "ECs3885", "id": "ECs3885"}, {"notes": {"original_bigg_ids": ["ECs2490"]}, "name": "ECs2490", "id": "ECs2490"}, {"notes": {"original_bigg_ids": ["ECs0203"]}, "name": "ECs0203", "id": "ECs0203"}, {"notes": {"original_bigg_ids": ["ECs4874"]}, "name": "ECs4874", "id": "ECs4874"}, {"notes": {"original_bigg_ids": ["ECs3973"]}, "name": "ECs3973", "id": "ECs3973"}, {"notes": {"original_bigg_ids": ["ECs4258"]}, "name": "ECs4258", "id": "ECs4258"}, {"notes": {"original_bigg_ids": ["ECs4096"]}, "name": "ECs4096", "id": "ECs4096"}, {"notes": {"original_bigg_ids": ["ECs4095"]}, "name": "ECs4095", "id": "ECs4095"}, {"notes": {"original_bigg_ids": ["ECs0852"]}, "name": "ECs0852", "id": "ECs0852"}, {"notes": {"original_bigg_ids": ["ECs4763"]}, "name": "ECs4763", "id": "ECs4763"}, {"notes": {"original_bigg_ids": ["ECs4917"]}, "name": "ECs4917", "id": "ECs4917"}, {"notes": {"original_bigg_ids": ["ECs2779"]}, "name": "ECs2779", "id": "ECs2779"}, {"notes": {"original_bigg_ids": ["ECs0264"]}, "name": "ECs0264", "id": "ECs0264"}, {"notes": {"original_bigg_ids": ["ECs5237"]}, "name": "ECs5237", "id": "ECs5237"}, {"notes": {"original_bigg_ids": ["ECs1015"]}, "name": "ECs1015", "id": "ECs1015"}, {"notes": {"original_bigg_ids": ["ECs3389"]}, "name": "ECs3389", "id": "ECs3389"}, {"notes": {"original_bigg_ids": ["ECs2349"]}, "name": "ECs2349", "id": "ECs2349"}, {"notes": {"original_bigg_ids": ["ECs1835"]}, "name": "ECs1835", "id": "ECs1835"}, {"notes": {"original_bigg_ids": ["ECs1836"]}, "name": "ECs1836", "id": "ECs1836"}, {"notes": {"original_bigg_ids": ["ECs0854"]}, "name": "ECs0854", "id": "ECs0854"}, {"notes": {"original_bigg_ids": ["ECs0054"]}, "name": "ECs0054", "id": "ECs0054"}, {"notes": {"original_bigg_ids": ["ECs3762"]}, "name": "ECs3762", "id": "ECs3762"}, {"notes": {"original_bigg_ids": ["ECs0125"]}, "name": "ECs0125", "id": "ECs0125"}, {"notes": {"original_bigg_ids": ["ECs3942"]}, "name": "ECs3942", "id": "ECs3942"}, {"notes": {"original_bigg_ids": ["ECs1052"]}, "name": "ECs1052", "id": "ECs1052"}, {"notes": {"original_bigg_ids": ["ECs0467"]}, "name": "ECs0467", "id": "ECs0467"}, {"notes": {"original_bigg_ids": ["ECs0066"]}, "name": "ECs0066", "id": "ECs0066"}, {"notes": {"original_bigg_ids": ["ECs0156"]}, "name": "ECs0156", "id": "ECs0156"}, {"notes": {"original_bigg_ids": ["ECs0157"]}, "name": "ECs0157", "id": "ECs0157"}, {"notes": {"original_bigg_ids": ["ECs0155"]}, "name": "ECs0155", "id": "ECs0155"}, {"notes": {"original_bigg_ids": ["ECs3571"]}, "name": "ECs3571", "id": "ECs3571"}, {"notes": {"original_bigg_ids": ["araH"]}, "name": "None", "id": "araH"}, {"notes": {"original_bigg_ids": ["ECs2609"]}, "name": "ECs2609", "id": "ECs2609"}, {"notes": {"original_bigg_ids": ["ECs2608"]}, "name": "ECs2608", "id": "ECs2608"}, {"notes": {"original_bigg_ids": ["ECs3698"]}, "name": "ECs3698", "id": "ECs3698"}, {"notes": {"original_bigg_ids": ["ECs2135"]}, "name": "ECs2135", "id": "ECs2135"}, {"notes": {"original_bigg_ids": ["ECs5097"]}, "name": "ECs5097", "id": "ECs5097"}, {"notes": {"original_bigg_ids": ["ECs5099"]}, "name": "ECs5099", "id": "ECs5099"}, {"notes": {"original_bigg_ids": ["ECs3814"]}, "name": "ECs3814", "id": "ECs3814"}, {"notes": {"original_bigg_ids": ["ECs2311"]}, "name": "ECs2311", "id": "ECs2311"}, {"notes": {"original_bigg_ids": ["ECs4889"]}, "name": "ECs4889", "id": "ECs4889"}, {"notes": {"original_bigg_ids": ["ECs4052"]}, "name": "ECs4052", "id": "ECs4052"}, {"notes": {"original_bigg_ids": ["ECs2586"]}, "name": "ECs2586", "id": "ECs2586"}, {"notes": {"original_bigg_ids": ["ECs3191"]}, "name": "ECs3191", "id": "ECs3191"}, {"notes": {"original_bigg_ids": ["ECs3194"]}, "name": "ECs3194", "id": "ECs3194"}, {"notes": {"original_bigg_ids": ["ECs3192"]}, "name": "ECs3192", "id": "ECs3192"}, {"notes": {"original_bigg_ids": ["ECs3190"]}, "name": "ECs3190", "id": "ECs3190"}, {"notes": {"original_bigg_ids": ["ECs0947"]}, "name": "ECs0947", "id": "ECs0947"}, {"notes": {"original_bigg_ids": ["ECs0944"]}, "name": "ECs0944", "id": "ECs0944"}, {"notes": {"original_bigg_ids": ["ECs0946"]}, "name": "ECs0946", "id": "ECs0946"}, {"notes": {"original_bigg_ids": ["ECs0945"]}, "name": "ECs0945", "id": "ECs0945"}, {"notes": {"original_bigg_ids": ["ECs0943"]}, "name": "ECs0943", "id": "ECs0943"}, {"notes": {"original_bigg_ids": ["ECs3794"]}, "name": "ECs3794", "id": "ECs3794"}, {"notes": {"original_bigg_ids": ["ECs4278"]}, "name": "ECs4278", "id": "ECs4278"}, {"notes": {"original_bigg_ids": ["ECs5168"]}, "name": "ECs5168", "id": "ECs5168"}, {"notes": {"original_bigg_ids": ["ECs5169"]}, "name": "ECs5169", "id": "ECs5169"}, {"notes": {"original_bigg_ids": ["ECs5170"]}, "name": "ECs5170", "id": "ECs5170"}, {"notes": {"original_bigg_ids": ["ECs5171"]}, "name": "ECs5171", "id": "ECs5171"}, {"notes": {"original_bigg_ids": ["iaaA"]}, "name": "None", "id": "iaaA"}, {"notes": {"original_bigg_ids": ["ECs2474"]}, "name": "ECs2474", "id": "ECs2474"}, {"notes": {"original_bigg_ids": ["ECs3833"]}, "name": "ECs3833", "id": "ECs3833"}, {"notes": {"original_bigg_ids": ["ECs0704"]}, "name": "ECs0704", "id": "ECs0704"}, {"notes": {"original_bigg_ids": ["ECs4686"]}, "name": "ECs4686", "id": "ECs4686"}, {"notes": {"original_bigg_ids": ["ECs1013"]}, "name": "ECs1013", "id": "ECs1013"}, {"notes": {"original_bigg_ids": ["ECs2057"]}, "name": "ECs2057", "id": "ECs2057"}, {"notes": {"original_bigg_ids": ["ECs4374"]}, "name": "ECs4374", "id": "ECs4374"}, {"notes": {"original_bigg_ids": ["ECs0135"]}, "name": "ECs0135", "id": "ECs0135"}, {"notes": {"original_bigg_ids": ["ECs5222"]}, "name": "ECs5222", "id": "ECs5222"}, {"notes": {"original_bigg_ids": ["ECs5221"]}, "name": "ECs5221", "id": "ECs5221"}, {"notes": {"original_bigg_ids": ["ECs5007"]}, "name": "ECs5007", "id": "ECs5007"}, {"notes": {"original_bigg_ids": ["ECs4869"]}, "name": "ECs4869", "id": "ECs4869"}, {"notes": {"original_bigg_ids": ["ECs0002"]}, "name": "ECs0002", "id": "ECs0002"}, {"notes": {"original_bigg_ids": ["ECs3440"]}, "name": "ECs3440", "id": "ECs3440"}, {"notes": {"original_bigg_ids": ["ECs5120"]}, "name": "ECs5120", "id": "ECs5120"}, {"notes": {"original_bigg_ids": ["ECs1011"]}, "name": "ECs1011", "id": "ECs1011"}, {"notes": {"original_bigg_ids": ["ECs2576"]}, "name": "ECs2576", "id": "ECs2576"}, {"notes": {"original_bigg_ids": ["ECs0693"]}, "name": "ECs0693", "id": "ECs0693"}, {"notes": {"original_bigg_ids": ["ECs0694"]}, "name": "ECs0694", "id": "ECs0694"}, {"notes": {"original_bigg_ids": ["ECs0691"]}, "name": "ECs0691", "id": "ECs0691"}, {"notes": {"original_bigg_ids": ["ECs0692"]}, "name": "ECs0692", "id": "ECs0692"}, {"notes": {"original_bigg_ids": ["ECs4408"]}, "name": "ECs4408", "id": "ECs4408"}, {"notes": {"original_bigg_ids": ["ECs5119"]}, "name": "ECs5119", "id": "ECs5119"}, {"notes": {"original_bigg_ids": ["ECs5105"]}, "name": "ECs5105", "id": "ECs5105"}, {"notes": {"original_bigg_ids": ["ECs5059"]}, "name": "ECs5059", "id": "ECs5059"}, {"notes": {"original_bigg_ids": ["ECs4375"]}, "name": "ECs4375", "id": "ECs4375"}, {"notes": {"original_bigg_ids": ["ECs1442"]}, "name": "ECs1442", "id": "ECs1442"}, {"notes": {"original_bigg_ids": ["ECs2453"]}, "name": "ECs2453", "id": "ECs2453"}, {"notes": {"original_bigg_ids": ["ECs2148"]}, "name": "ECs2148", "id": "ECs2148"}, {"notes": {"original_bigg_ids": ["ECs2820"]}, "name": "ECs2820", "id": "ECs2820"}, {"notes": {"original_bigg_ids": ["ECs4679"]}, "name": "ECs4679", "id": "ECs4679"}, {"notes": {"original_bigg_ids": ["ECs4674"]}, "name": "ECs4674", "id": "ECs4674"}, {"notes": {"original_bigg_ids": ["ECs4681"]}, "name": "ECs4681", "id": "ECs4681"}, {"notes": {"original_bigg_ids": ["ECs4677"]}, "name": "ECs4677", "id": "ECs4677"}, {"notes": {"original_bigg_ids": ["ECs4680"]}, "name": "ECs4680", "id": "ECs4680"}, {"notes": {"original_bigg_ids": ["ECs4678"]}, "name": "ECs4678", "id": "ECs4678"}, {"notes": {"original_bigg_ids": ["ECs4675"]}, "name": "ECs4675", "id": "ECs4675"}, {"notes": {"original_bigg_ids": ["ECs4673"]}, "name": "ECs4673", "id": "ECs4673"}, {"notes": {"original_bigg_ids": ["ECs4676"]}, "name": "ECs4676", "id": "ECs4676"}, {"notes": {"original_bigg_ids": ["ECs0358"]}, "name": "ECs0358", "id": "ECs0358"}, {"notes": {"original_bigg_ids": ["ECs0905"]}, "name": "ECs0905", "id": "ECs0905"}, {"notes": {"original_bigg_ids": ["ECs4780"]}, "name": "ECs4780", "id": "ECs4780"}, {"notes": {"original_bigg_ids": ["ECs4779"]}, "name": "ECs4779", "id": "ECs4779"}, {"notes": {"original_bigg_ids": ["ECs5192"]}, "name": "ECs5192", "id": "ECs5192"}, {"notes": {"original_bigg_ids": ["ECs0853"]}, "name": "ECs0853", "id": "ECs0853"}, {"notes": {"original_bigg_ids": ["ECs1017"]}, "name": "ECs1017", "id": "ECs1017"}, {"notes": {"original_bigg_ids": ["ECs0420"]}, "name": "ECs0420", "id": "ECs0420"}, {"notes": {"original_bigg_ids": ["ECs0421"]}, "name": "ECs0421", "id": "ECs0421"}, {"notes": {"original_bigg_ids": ["ECs0419"]}, "name": "ECs0419", "id": "ECs0419"}, {"notes": {"original_bigg_ids": ["ECs1016"]}, "name": "ECs1016", "id": "ECs1016"}, {"notes": {"original_bigg_ids": ["ECs1019"]}, "name": "ECs1019", "id": "ECs1019"}, {"notes": {"original_bigg_ids": ["ECs1721"]}, "name": "ECs1721", "id": "ECs1721"}, {"notes": {"original_bigg_ids": ["ECs5114"]}, "name": "ECs5114", "id": "ECs5114"}, {"notes": {"original_bigg_ids": ["ECs2438"]}, "name": "ECs2438", "id": "ECs2438"}, {"notes": {"original_bigg_ids": ["ECs4871"]}, "name": "ECs4871", "id": "ECs4871"}, {"notes": {"original_bigg_ids": ["ECs4075"]}, "name": "ECs4075", "id": "ECs4075"}, {"notes": {"original_bigg_ids": ["ECs1842"]}, "name": "ECs1842", "id": "ECs1842"}, {"notes": {"original_bigg_ids": ["ECs0583"]}, "name": "ECs0583", "id": "ECs0583"}, {"notes": {"original_bigg_ids": ["ECs3747"]}, "name": "ECs3747", "id": "ECs3747"}, {"notes": {"original_bigg_ids": ["ECs0372"]}, "name": "ECs0372", "id": "ECs0372"}, {"notes": {"original_bigg_ids": ["ECs0035"]}, "name": "ECs0035", "id": "ECs0035"}, {"notes": {"original_bigg_ids": ["ECs0036"]}, "name": "ECs0036", "id": "ECs0036"}, {"notes": {"original_bigg_ids": ["ECs0498"]}, "name": "ECs0498", "id": "ECs0498"}, {"notes": {"original_bigg_ids": ["ECs4318"]}, "name": "ECs4318", "id": "ECs4318"}, {"notes": {"original_bigg_ids": ["ECs4840"]}, "name": "ECs4840", "id": "ECs4840"}, {"notes": {"original_bigg_ids": ["ECs0780"]}, "name": "ECs0780", "id": "ECs0780"}, {"notes": {"original_bigg_ids": ["ECs3928"]}, "name": "ECs3928", "id": "ECs3928"}, {"notes": {"original_bigg_ids": ["ECs4843"]}, "name": "ECs4843", "id": "ECs4843"}, {"notes": {"original_bigg_ids": ["ECs3654"]}, "name": "ECs3654", "id": "ECs3654"}, {"notes": {"original_bigg_ids": ["ECs1713"]}, "name": "ECs1713", "id": "ECs1713"}, {"notes": {"original_bigg_ids": ["ECs2370"]}, "name": "ECs2370", "id": "ECs2370"}, {"notes": {"original_bigg_ids": ["ECs3015"]}, "name": "ECs3015", "id": "ECs3015"}, {"notes": {"original_bigg_ids": ["ECs3017"]}, "name": "ECs3017", "id": "ECs3017"}, {"notes": {"original_bigg_ids": ["ECs3018"]}, "name": "ECs3018", "id": "ECs3018"}, {"notes": {"original_bigg_ids": ["ECs3016"]}, "name": "ECs3016", "id": "ECs3016"}, {"notes": {"original_bigg_ids": ["ECs0360"]}, "name": "ECs0360", "id": "ECs0360"}, {"notes": {"original_bigg_ids": ["ECs2510"]}, "name": "ECs2510", "id": "ECs2510"}, {"notes": {"original_bigg_ids": ["ECs0357"]}, "name": "ECs0357", "id": "ECs0357"}, {"notes": {"original_bigg_ids": ["ECs3463"]}, "name": "ECs3463", "id": "ECs3463"}, {"notes": {"original_bigg_ids": ["ECs3462"]}, "name": "ECs3462", "id": "ECs3462"}, {"notes": {"original_bigg_ids": ["ECs3213"]}, "name": "ECs3213", "id": "ECs3213"}, {"notes": {"original_bigg_ids": ["ECs5022"]}, "name": "ECs5022", "id": "ECs5022"}, {"notes": {"original_bigg_ids": ["ECs3406"]}, "name": "ECs3406", "id": "ECs3406"}, {"notes": {"original_bigg_ids": ["ECs3404"]}, "name": "ECs3404", "id": "ECs3404"}, {"notes": {"original_bigg_ids": ["ECs3408"]}, "name": "ECs3408", "id": "ECs3408"}, {"notes": {"original_bigg_ids": ["ECs3405"]}, "name": "ECs3405", "id": "ECs3405"}, {"notes": {"original_bigg_ids": ["ECs0655"]}, "name": "ECs0655", "id": "ECs0655"}, {"notes": {"original_bigg_ids": ["ECs0653"]}, "name": "ECs0653", "id": "ECs0653"}, {"notes": {"original_bigg_ids": ["ECs0654"]}, "name": "ECs0654", "id": "ECs0654"}, {"notes": {"original_bigg_ids": ["ECs0656"]}, "name": "ECs0656", "id": "ECs0656"}, {"notes": {"original_bigg_ids": ["ECs0651"]}, "name": "ECs0651", "id": "ECs0651"}, {"notes": {"original_bigg_ids": ["ECs0867"]}, "name": "ECs0867", "id": "ECs0867"}, {"notes": {"original_bigg_ids": ["ECs1749"]}, "name": "ECs1749", "id": "ECs1749"}, {"notes": {"original_bigg_ids": ["ECs0159"]}, "name": "ECs0159", "id": "ECs0159"}, {"notes": {"original_bigg_ids": ["ECs2298"]}, "name": "ECs2298", "id": "ECs2298"}, {"notes": {"original_bigg_ids": ["ECs0516"]}, "name": "ECs0516", "id": "ECs0516"}, {"notes": {"original_bigg_ids": ["ECs3332"]}, "name": "ECs3332", "id": "ECs3332"}, {"notes": {"original_bigg_ids": ["ECs3923"]}, "name": "ECs3923", "id": "ECs3923"}, {"notes": {"original_bigg_ids": ["ECs4746"]}, "name": "ECs4746", "id": "ECs4746"}, {"notes": {"original_bigg_ids": ["ECs3066"]}, "name": "ECs3066", "id": "ECs3066"}, {"notes": {"original_bigg_ids": ["ECs0997"]}, "name": "ECs0997", "id": "ECs0997"}, {"notes": {"original_bigg_ids": ["ECs1480"]}, "name": "ECs1480", "id": "ECs1480"}, {"notes": {"original_bigg_ids": ["ECs3620"]}, "name": "ECs3620", "id": "ECs3620"}, {"notes": {"original_bigg_ids": ["ECs0859"]}, "name": "ECs0859", "id": "ECs0859"}, {"notes": {"original_bigg_ids": ["ECs0861"]}, "name": "ECs0861", "id": "ECs0861"}, {"notes": {"original_bigg_ids": ["ECs3307"]}, "name": "ECs3307", "id": "ECs3307"}, {"notes": {"original_bigg_ids": ["ECs4789"]}, "name": "ECs4789", "id": "ECs4789"}, {"notes": {"original_bigg_ids": ["ECs0041"]}, "name": "ECs0041", "id": "ECs0041"}, {"notes": {"original_bigg_ids": ["ECs0040"]}, "name": "ECs0040", "id": "ECs0040"}, {"notes": {"original_bigg_ids": ["ECs0039"]}, "name": "ECs0039", "id": "ECs0039"}, {"notes": {"original_bigg_ids": ["ECs3541"]}, "name": "ECs3541", "id": "ECs3541"}, {"notes": {"original_bigg_ids": ["ECs3540"]}, "name": "ECs3540", "id": "ECs3540"}, {"notes": {"original_bigg_ids": ["ECs3542"]}, "name": "ECs3542", "id": "ECs3542"}, {"notes": {"original_bigg_ids": ["ECs5093"]}, "name": "ECs5093", "id": "ECs5093"}, {"notes": {"original_bigg_ids": ["ECs0043"]}, "name": "ECs0043", "id": "ECs0043"}, {"notes": {"original_bigg_ids": ["ECs0745"]}, "name": "ECs0745", "id": "ECs0745"}, {"notes": {"original_bigg_ids": ["ECs0390"]}, "name": "ECs0390", "id": "ECs0390"}, {"notes": {"original_bigg_ids": ["ECs0389"]}, "name": "ECs0389", "id": "ECs0389"}, {"notes": {"original_bigg_ids": ["ECs4774"]}, "name": "ECs4774", "id": "ECs4774"}, {"notes": {"original_bigg_ids": ["ECs3640"]}, "name": "ECs3640", "id": "ECs3640"}, {"notes": {"original_bigg_ids": ["ECs0127"]}, "name": "ECs0127", "id": "ECs0127"}, {"notes": {"original_bigg_ids": ["ECs0537"]}, "name": "ECs0537", "id": "ECs0537"}, {"notes": {"original_bigg_ids": ["ECs4268"]}, "name": "ECs4268", "id": "ECs4268"}, {"notes": {"original_bigg_ids": ["ECs1885"]}, "name": "ECs1885", "id": "ECs1885"}, {"notes": {"original_bigg_ids": ["ECs0393"]}, "name": "ECs0393", "id": "ECs0393"}, {"notes": {"original_bigg_ids": ["ECs0394"]}, "name": "ECs0394", "id": "ECs0394"}, {"notes": {"original_bigg_ids": ["dcyD"]}, "name": "None", "id": "dcyD"}, {"notes": {"original_bigg_ids": ["ECs4645"]}, "name": "ECs4645", "id": "ECs4645"}, {"notes": {"original_bigg_ids": ["ECs3892"]}, "name": "ECs3892", "id": "ECs3892"}, {"notes": {"original_bigg_ids": ["ECs3292"]}, "name": "ECs3292", "id": "ECs3292"}, {"notes": {"original_bigg_ids": ["ECs3286"]}, "name": "ECs3286", "id": "ECs3286"}, {"notes": {"original_bigg_ids": ["ECs3670"]}, "name": "ECs3670", "id": "ECs3670"}, {"notes": {"original_bigg_ids": ["ECs2330"]}, "name": "ECs2330", "id": "ECs2330"}, {"notes": {"original_bigg_ids": ["ECs0588"]}, "name": "ECs0588", "id": "ECs0588"}, {"notes": {"original_bigg_ids": ["ECs0972"]}, "name": "ECs0972", "id": "ECs0972"}, {"notes": {"original_bigg_ids": ["ECs0971"]}, "name": "ECs0971", "id": "ECs0971"}, {"notes": {"original_bigg_ids": ["ECs1135"]}, "name": "ECs1135", "id": "ECs1135"}, {"notes": {"original_bigg_ids": ["ECs1134"]}, "name": "ECs1134", "id": "ECs1134"}, {"notes": {"original_bigg_ids": ["ECs0768"]}, "name": "ECs0768", "id": "ECs0768"}, {"notes": {"original_bigg_ids": ["ECs0769"]}, "name": "ECs0769", "id": "ECs0769"}, {"notes": {"original_bigg_ids": ["ECs0484"]}, "name": "ECs0484", "id": "ECs0484"}, {"notes": {"original_bigg_ids": ["ECs0483"]}, "name": "ECs0483", "id": "ECs0483"}, {"notes": {"original_bigg_ids": ["ECs0485"]}, "name": "ECs0485", "id": "ECs0485"}, {"notes": {"original_bigg_ids": ["ECs0486"]}, "name": "ECs0486", "id": "ECs0486"}, {"notes": {"original_bigg_ids": ["ECs3035"]}, "name": "ECs3035", "id": "ECs3035"}, {"notes": {"original_bigg_ids": ["ECs0690"]}, "name": "ECs0690", "id": "ECs0690"}, {"notes": {"original_bigg_ids": ["ECs3054"]}, "name": "ECs3054", "id": "ECs3054"}, {"notes": {"original_bigg_ids": ["ECs2873"]}, "name": "ECs2873", "id": "ECs2873"}, {"notes": {"original_bigg_ids": ["ECs0993"]}, "name": "ECs0993", "id": "ECs0993"}, {"notes": {"original_bigg_ids": ["ECs4481"]}, "name": "ECs4481", "id": "ECs4481"}, {"notes": {"original_bigg_ids": ["ECs1684"]}, "name": "ECs1684", "id": "ECs1684"}, {"notes": {"original_bigg_ids": ["ECs5025"]}, "name": "ECs5025", "id": "ECs5025"}, {"notes": {"original_bigg_ids": ["ECs3744"]}, "name": "ECs3744", "id": "ECs3744"}, {"notes": {"original_bigg_ids": ["ECs3695"]}, "name": "ECs3695", "id": "ECs3695"}, {"notes": {"original_bigg_ids": ["ECs4739"]}, "name": "ECs4739", "id": "ECs4739"}, {"notes": {"original_bigg_ids": ["ECs0177"]}, "name": "ECs0177", "id": "ECs0177"}, {"notes": {"original_bigg_ids": ["ECs3929"]}, "name": "ECs3929", "id": "ECs3929"}, {"notes": {"original_bigg_ids": ["ECs0856"]}, "name": "ECs0856", "id": "ECs0856"}, {"notes": {"original_bigg_ids": ["ECs2440"]}, "name": "ECs2440", "id": "ECs2440"}, {"notes": {"original_bigg_ids": ["ECs2872"]}, "name": "ECs2872", "id": "ECs2872"}, {"notes": {"original_bigg_ids": ["ECs3227"]}, "name": "ECs3227", "id": "ECs3227"}, {"notes": {"original_bigg_ids": ["ECs4835"]}, "name": "ECs4835", "id": "ECs4835"}, {"notes": {"original_bigg_ids": ["ECs4406"]}, "name": "ECs4406", "id": "ECs4406"}, {"notes": {"original_bigg_ids": ["ECs2411"]}, "name": "ECs2411", "id": "ECs2411"}, {"notes": {"original_bigg_ids": ["ECs0782"]}, "name": "ECs0782", "id": "ECs0782"}, {"notes": {"original_bigg_ids": ["ECs3464"]}, "name": "ECs3464", "id": "ECs3464"}, {"notes": {"original_bigg_ids": ["ECs4523"]}, "name": "ECs4523", "id": "ECs4523"}, {"notes": {"original_bigg_ids": ["ECs4705"]}, "name": "ECs4705", "id": "ECs4705"}, {"notes": {"original_bigg_ids": ["ECs1705"]}, "name": "ECs1705", "id": "ECs1705"}, {"notes": {"original_bigg_ids": ["ECs1703"]}, "name": "ECs1703", "id": "ECs1703"}, {"notes": {"original_bigg_ids": ["ECs1704"]}, "name": "ECs1704", "id": "ECs1704"}, {"notes": {"original_bigg_ids": ["ECs0635"]}, "name": "ECs0635", "id": "ECs0635"}, {"notes": {"original_bigg_ids": ["ECs0633"]}, "name": "ECs0633", "id": "ECs0633"}, {"notes": {"original_bigg_ids": ["ECs3407"]}, "name": "ECs3407", "id": "ECs3407"}, {"notes": {"original_bigg_ids": ["ECs0403"]}, "name": "ECs0403", "id": "ECs0403"}, {"notes": {"original_bigg_ids": ["ECs0034"]}, "name": "ECs0034", "id": "ECs0034"}, {"notes": {"original_bigg_ids": ["ECs3340"]}, "name": "ECs3340", "id": "ECs3340"}, {"notes": {"original_bigg_ids": ["ECs2312"]}, "name": "ECs2312", "id": "ECs2312"}, {"notes": {"original_bigg_ids": ["ECs0051"]}, "name": "ECs0051", "id": "ECs0051"}, {"notes": {"original_bigg_ids": ["ECs3199"]}, "name": "ECs3199", "id": "ECs3199"}, {"notes": {"original_bigg_ids": ["ECs4857"]}, "name": "ECs4857", "id": "ECs4857"}, {"notes": {"original_bigg_ids": ["ECs3150"]}, "name": "ECs3150", "id": "ECs3150"}, {"notes": {"original_bigg_ids": ["ECs0771"]}, "name": "ECs0771", "id": "ECs0771"}, {"notes": {"original_bigg_ids": ["ECs3941"]}, "name": "ECs3941", "id": "ECs3941"}, {"notes": {"original_bigg_ids": ["ECs1029"]}, "name": "ECs1029", "id": "ECs1029"}, {"notes": {"original_bigg_ids": ["ECs1440"]}, "name": "ECs1440", "id": "ECs1440"}, {"notes": {"original_bigg_ids": ["ECs4056"]}, "name": "ECs4056", "id": "ECs4056"}, {"notes": {"original_bigg_ids": ["ECs0616"]}, "name": "ECs0616", "id": "ECs0616"}, {"notes": {"original_bigg_ids": ["ECs3187"]}, "name": "ECs3187", "id": "ECs3187"}, {"notes": {"original_bigg_ids": ["ECs4231"]}, "name": "ECs4231", "id": "ECs4231"}, {"notes": {"original_bigg_ids": ["ECs2400"]}, "name": "ECs2400", "id": "ECs2400"}, {"notes": {"original_bigg_ids": ["ECs0475"]}, "name": "ECs0475", "id": "ECs0475"}, {"notes": {"original_bigg_ids": ["ECs0032"]}, "name": "ECs0032", "id": "ECs0032"}, {"notes": {"original_bigg_ids": ["ECs3115"]}, "name": "ECs3115", "id": "ECs3115"}, {"notes": {"original_bigg_ids": ["ECs0980"]}, "name": "ECs0980", "id": "ECs0980"}, {"notes": {"original_bigg_ids": ["ECs0981"]}, "name": "ECs0981", "id": "ECs0981"}, {"notes": {"original_bigg_ids": ["ECs0979"]}, "name": "ECs0979", "id": "ECs0979"}, {"notes": {"original_bigg_ids": ["ECs2575"]}, "name": "ECs2575", "id": "ECs2575"}, {"notes": {"original_bigg_ids": ["ECs0103"]}, "name": "ECs0103", "id": "ECs0103"}, {"notes": {"original_bigg_ids": ["ECs0107"]}, "name": "ECs0107", "id": "ECs0107"}, {"notes": {"original_bigg_ids": ["ECs4708"]}, "name": "ECs4708", "id": "ECs4708"}, {"notes": {"original_bigg_ids": ["ECs0479"]}, "name": "ECs0479", "id": "ECs0479"}, {"notes": {"original_bigg_ids": ["ECs5340"]}, "name": "ECs5340", "id": "ECs5340"}, {"notes": {"original_bigg_ids": ["ECs4783"]}, "name": "ECs4783", "id": "ECs4783"}, {"notes": {"original_bigg_ids": ["ECs1680"]}, "name": "ECs1680", "id": "ECs1680"}, {"notes": {"original_bigg_ids": ["ECs3765"]}, "name": "ECs3765", "id": "ECs3765"}, {"notes": {"original_bigg_ids": ["ECs4714"]}, "name": "ECs4714", "id": "ECs4714"}, {"notes": {"original_bigg_ids": ["ECs5117"]}, "name": "ECs5117", "id": "ECs5117"}, {"notes": {"original_bigg_ids": ["ECs3448"]}, "name": "ECs3448", "id": "ECs3448"}, {"notes": {"original_bigg_ids": ["ECs0643"]}, "name": "ECs0643", "id": "ECs0643"}, {"notes": {"original_bigg_ids": ["ECs2318"]}, "name": "ECs2318", "id": "ECs2318"}, {"notes": {"original_bigg_ids": ["ECs1476"]}, "name": "ECs1476", "id": "ECs1476"}, {"notes": {"original_bigg_ids": ["ECs3038"]}, "name": "ECs3038", "id": "ECs3038"}, {"notes": {"original_bigg_ids": ["ECs3039"]}, "name": "ECs3039", "id": "ECs3039"}, {"notes": {"original_bigg_ids": ["ECs1740"]}, "name": "ECs1740", "id": "ECs1740"}, {"notes": {"original_bigg_ids": ["ECs5341"]}, "name": "ECs5341", "id": "ECs5341"}, {"notes": {"original_bigg_ids": ["ECs5343"]}, "name": "ECs5343", "id": "ECs5343"}, {"notes": {"original_bigg_ids": ["ECs4515"]}, "name": "ECs4515", "id": "ECs4515"}, {"notes": {"original_bigg_ids": ["ECs3139"]}, "name": "ECs3139", "id": "ECs3139"}, {"notes": {"original_bigg_ids": ["ECs0175"]}, "name": "ECs0175", "id": "ECs0175"}, {"notes": {"original_bigg_ids": ["ECs0474"]}, "name": "ECs0474", "id": "ECs0474"}, {"notes": {"original_bigg_ids": ["ECs4447"]}, "name": "ECs4447", "id": "ECs4447"}, {"notes": {"original_bigg_ids": ["ECs3798"]}, "name": "ECs3798", "id": "ECs3798"}, {"notes": {"original_bigg_ids": ["ECs2488"]}, "name": "ECs2488", "id": "ECs2488"}, {"notes": {"original_bigg_ids": ["ECs1861"]}, "name": "ECs1861", "id": "ECs1861"}, {"notes": {"original_bigg_ids": ["ECs4718"]}, "name": "ECs4718", "id": "ECs4718"}, {"notes": {"original_bigg_ids": ["ECs4727"]}, "name": "ECs4727", "id": "ECs4727"}, {"notes": {"original_bigg_ids": ["ECs4725"]}, "name": "ECs4725", "id": "ECs4725"}, {"notes": {"original_bigg_ids": ["ECs3224"]}, "name": "ECs3224", "id": "ECs3224"}, {"notes": {"original_bigg_ids": ["ECs2560"]}, "name": "ECs2560", "id": "ECs2560"}, {"notes": {"original_bigg_ids": ["ECs2561"]}, "name": "ECs2561", "id": "ECs2561"}, {"notes": {"original_bigg_ids": ["ECs1432"]}, "name": "ECs1432", "id": "ECs1432"}, {"notes": {"original_bigg_ids": ["ECs2565"]}, "name": "ECs2565", "id": "ECs2565"}, {"notes": {"original_bigg_ids": ["ECs3258"]}, "name": "ECs3258", "id": "ECs3258"}, {"notes": {"original_bigg_ids": ["ECs3639"]}, "name": "ECs3639", "id": "ECs3639"}, {"notes": {"original_bigg_ids": ["ECs0622"]}, "name": "ECs0622", "id": "ECs0622"}, {"notes": {"original_bigg_ids": ["ECs0624"]}, "name": "ECs0624", "id": "ECs0624"}, {"notes": {"original_bigg_ids": ["ECs3312"]}, "name": "ECs3312", "id": "ECs3312"}, {"notes": {"original_bigg_ids": ["ECs3311"]}, "name": "ECs3311", "id": "ECs3311"}, {"notes": {"original_bigg_ids": ["ECs4875"]}, "name": "ECs4875", "id": "ECs4875"}, {"notes": {"original_bigg_ids": ["ECs0903"]}, "name": "ECs0903", "id": "ECs0903"}, {"notes": {"original_bigg_ids": ["ECs0899"]}, "name": "ECs0899", "id": "ECs0899"}, {"notes": {"original_bigg_ids": ["ECs4603"]}, "name": "ECs4603", "id": "ECs4603"}, {"notes": {"original_bigg_ids": ["ECs0455"]}, "name": "ECs0455", "id": "ECs0455"}, {"notes": {"original_bigg_ids": ["ECs0506"]}, "name": "ECs0506", "id": "ECs0506"}, {"notes": {"original_bigg_ids": ["ECs2408"]}, "name": "ECs2408", "id": "ECs2408"}, {"notes": {"original_bigg_ids": ["ECs2514"]}, "name": "ECs2514", "id": "ECs2514"}, {"notes": {"original_bigg_ids": ["ECs4772"]}, "name": "ECs4772", "id": "ECs4772"}, {"notes": {"original_bigg_ids": ["ECs3619"]}, "name": "ECs3619", "id": "ECs3619"}, {"notes": {"original_bigg_ids": ["ECs3618"]}, "name": "ECs3618", "id": "ECs3618"}, {"notes": {"original_bigg_ids": ["ECs2482"]}, "name": "ECs2482", "id": "ECs2482"}, {"notes": {"original_bigg_ids": ["ECs3796"]}, "name": "ECs3796", "id": "ECs3796"}, {"notes": {"original_bigg_ids": ["ECs2900"]}, "name": "ECs2900", "id": "ECs2900"}, {"notes": {"original_bigg_ids": ["ECs3806"]}, "name": "ECs3806", "id": "ECs3806"}, {"notes": {"original_bigg_ids": ["ECs4850"]}, "name": "ECs4850", "id": "ECs4850"}, {"notes": {"original_bigg_ids": ["ECs5209"]}, "name": "ECs5209", "id": "ECs5209"}, {"notes": {"original_bigg_ids": ["ECs3662"]}, "name": "ECs3662", "id": "ECs3662"}, {"notes": {"original_bigg_ids": ["ECs3663"]}, "name": "ECs3663", "id": "ECs3663"}, {"notes": {"original_bigg_ids": ["ECs3660"]}, "name": "ECs3660", "id": "ECs3660"}, {"notes": {"original_bigg_ids": ["ECs0528"]}, "name": "ECs0528", "id": "ECs0528"}, {"notes": {"original_bigg_ids": ["ECs4819"]}, "name": "ECs4819", "id": "ECs4819"}, {"notes": {"original_bigg_ids": ["ECs4818"]}, "name": "ECs4818", "id": "ECs4818"}, {"notes": {"original_bigg_ids": ["ECs2079"]}, "name": "ECs2079", "id": "ECs2079"}, {"notes": {"original_bigg_ids": ["ECs2080"]}, "name": "ECs2080", "id": "ECs2080"}, {"notes": {"original_bigg_ids": ["ECs2078"]}, "name": "ECs2078", "id": "ECs2078"}, {"notes": {"original_bigg_ids": ["ECs1018"]}, "name": "ECs1018", "id": "ECs1018"}, {"notes": {"original_bigg_ids": ["ECs4251"]}, "name": "ECs4251", "id": "ECs4251"}, {"notes": {"original_bigg_ids": ["ECs3271"]}, "name": "ECs3271", "id": "ECs3271"}, {"notes": {"original_bigg_ids": ["ECs0629"]}, "name": "ECs0629", "id": "ECs0629"}, {"notes": {"original_bigg_ids": ["ECs0631"]}, "name": "ECs0631", "id": "ECs0631"}, {"notes": {"original_bigg_ids": ["ECs0627"]}, "name": "ECs0627", "id": "ECs0627"}, {"notes": {"original_bigg_ids": ["ECs0628"]}, "name": "ECs0628", "id": "ECs0628"}, {"notes": {"original_bigg_ids": ["ECs0883"]}, "name": "ECs0883", "id": "ECs0883"}, {"notes": {"original_bigg_ids": ["ECs3047"]}, "name": "ECs3047", "id": "ECs3047"}, {"notes": {"original_bigg_ids": ["ECs0154"]}, "name": "ECs0154", "id": "ECs0154"}, {"notes": {"original_bigg_ids": ["ECs0623"]}, "name": "ECs0623", "id": "ECs0623"}, {"notes": {"original_bigg_ids": ["ECs0630"]}, "name": "ECs0630", "id": "ECs0630"}, {"notes": {"original_bigg_ids": ["ECs5327"]}, "name": "ECs5327", "id": "ECs5327"}, {"notes": {"original_bigg_ids": ["ECs5187"]}, "name": "ECs5187", "id": "ECs5187"}, {"notes": {"original_bigg_ids": ["ECs3579"]}, "name": "ECs3579", "id": "ECs3579"}, {"notes": {"original_bigg_ids": ["ECs3347"]}, "name": "ECs3347", "id": "ECs3347"}, {"notes": {"original_bigg_ids": ["ECs3580"]}, "name": "ECs3580", "id": "ECs3580"}, {"notes": {"original_bigg_ids": ["ECs3349"]}, "name": "ECs3349", "id": "ECs3349"}, {"notes": {"original_bigg_ids": ["ECs3576"]}, "name": "ECs3576", "id": "ECs3576"}, {"notes": {"original_bigg_ids": ["ECs3575"]}, "name": "ECs3575", "id": "ECs3575"}, {"notes": {"original_bigg_ids": ["ECs3578"]}, "name": "ECs3578", "id": "ECs3578"}, {"notes": {"original_bigg_ids": ["ECs3350"]}, "name": "ECs3350", "id": "ECs3350"}, {"notes": {"original_bigg_ids": ["ECs3346"]}, "name": "ECs3346", "id": "ECs3346"}, {"notes": {"original_bigg_ids": ["ECs3348"]}, "name": "ECs3348", "id": "ECs3348"}, {"notes": {"original_bigg_ids": ["ECs3352"]}, "name": "ECs3352", "id": "ECs3352"}, {"notes": {"original_bigg_ids": ["ECs3344"]}, "name": "ECs3344", "id": "ECs3344"}, {"notes": {"original_bigg_ids": ["ECs3351"]}, "name": "ECs3351", "id": "ECs3351"}, {"notes": {"original_bigg_ids": ["ECs3343"]}, "name": "ECs3343", "id": "ECs3343"}, {"notes": {"original_bigg_ids": ["ECs5061"]}, "name": "ECs5061", "id": "ECs5061"}, {"notes": {"original_bigg_ids": ["ECs3345"]}, "name": "ECs3345", "id": "ECs3345"}, {"notes": {"original_bigg_ids": ["ECs0715"]}, "name": "ECs0715", "id": "ECs0715"}, {"notes": {"original_bigg_ids": ["ECs4849"]}, "name": "ECs4849", "id": "ECs4849"}, {"notes": {"original_bigg_ids": ["ECs3767"]}, "name": "ECs3767", "id": "ECs3767"}, {"notes": {"original_bigg_ids": ["ECs4153"]}, "name": "ECs4153", "id": "ECs4153"}, {"notes": {"original_bigg_ids": ["ECs0028"]}, "name": "ECs0028", "id": "ECs0028"}, {"notes": {"original_bigg_ids": ["ECs1020"]}, "name": "ECs1020", "id": "ECs1020"}, {"notes": {"original_bigg_ids": ["ECs3782"]}, "name": "ECs3782", "id": "ECs3782"}, {"notes": {"original_bigg_ids": ["ECs3254"]}, "name": "ECs3254", "id": "ECs3254"}, {"notes": {"original_bigg_ids": ["ECs3354"]}, "name": "ECs3354", "id": "ECs3354"}, {"notes": {"original_bigg_ids": ["ECs0987"]}, "name": "ECs0987", "id": "ECs0987"}, {"notes": {"original_bigg_ids": ["ECs5134"]}, "name": "ECs5134", "id": "ECs5134"}, {"notes": {"original_bigg_ids": ["ECs5135"]}, "name": "ECs5135", "id": "ECs5135"}, {"notes": {"original_bigg_ids": ["ECs5132"]}, "name": "ECs5132", "id": "ECs5132"}, {"notes": {"original_bigg_ids": ["ECs5133"]}, "name": "ECs5133", "id": "ECs5133"}, {"notes": {"original_bigg_ids": ["ECs3060"]}, "name": "ECs3060", "id": "ECs3060"}, {"notes": {"original_bigg_ids": ["ECs4222"]}, "name": "ECs4222", "id": "ECs4222"}, {"notes": {"original_bigg_ids": ["ECs4223"]}, "name": "ECs4223", "id": "ECs4223"}, {"notes": {"original_bigg_ids": ["ECs4224"]}, "name": "ECs4224", "id": "ECs4224"}, {"notes": {"original_bigg_ids": ["ECs4221"]}, "name": "ECs4221", "id": "ECs4221"}, {"notes": {"original_bigg_ids": ["ECs5280"]}, "name": "ECs5280", "id": "ECs5280"}, {"notes": {"original_bigg_ids": ["ECs3059"]}, "name": "ECs3059", "id": "ECs3059"}, {"notes": {"original_bigg_ids": ["ECs3061"]}, "name": "ECs3061", "id": "ECs3061"}, {"notes": {"original_bigg_ids": ["ECs1734"]}, "name": "ECs1734", "id": "ECs1734"}, {"notes": {"original_bigg_ids": ["ECs3661"]}, "name": "ECs3661", "id": "ECs3661"}, {"notes": {"original_bigg_ids": ["ECs2317"]}, "name": "ECs2317", "id": "ECs2317"}, {"notes": {"original_bigg_ids": ["ECs0660"]}, "name": "ECs0660", "id": "ECs0660"}, {"notes": {"original_bigg_ids": ["ECs4672"]}, "name": "ECs4672", "id": "ECs4672"}, {"notes": {"original_bigg_ids": ["ECs1158"]}, "name": "ECs1158", "id": "ECs1158"}, {"notes": {"original_bigg_ids": ["ECs4722"]}, "name": "ECs4722", "id": "ECs4722"}, {"notes": {"original_bigg_ids": ["ECs0158"]}, "name": "ECs0158", "id": "ECs0158"}, {"notes": {"original_bigg_ids": ["ECs3399"]}, "name": "ECs3399", "id": "ECs3399"}, {"notes": {"original_bigg_ids": ["ECs5037"]}, "name": "ECs5037", "id": "ECs5037"}, {"notes": {"original_bigg_ids": ["ECs5024"]}, "name": "ECs5024", "id": "ECs5024"}, {"notes": {"original_bigg_ids": ["ECs4296"]}, "name": "ECs4296", "id": "ECs4296"}, {"notes": {"original_bigg_ids": ["ECs4297"]}, "name": "ECs4297", "id": "ECs4297"}, {"notes": {"original_bigg_ids": ["ECs4299"]}, "name": "ECs4299", "id": "ECs4299"}, {"notes": {"original_bigg_ids": ["ECs4298"]}, "name": "ECs4298", "id": "ECs4298"}, {"notes": {"original_bigg_ids": ["ECs4486"]}, "name": "ECs4486", "id": "ECs4486"}, {"notes": {"original_bigg_ids": ["ECs3126"]}, "name": "ECs3126", "id": "ECs3126"}, {"notes": {"original_bigg_ids": ["ECs3128"]}, "name": "ECs3128", "id": "ECs3128"}, {"notes": {"original_bigg_ids": ["ECs4269"]}, "name": "ECs4269", "id": "ECs4269"}, {"notes": {"original_bigg_ids": ["ECs3127"]}, "name": "ECs3127", "id": "ECs3127"}, {"notes": {"original_bigg_ids": ["ECs0270"]}, "name": "ECs0270", "id": "ECs0270"}, {"notes": {"original_bigg_ids": ["ECs0708"]}, "name": "ECs0708", "id": "ECs0708"}, {"notes": {"original_bigg_ids": ["ECs2562"]}, "name": "ECs2562", "id": "ECs2562"}, {"notes": {"original_bigg_ids": ["ECs4006"]}, "name": "ECs4006", "id": "ECs4006"}, {"notes": {"original_bigg_ids": ["ECs5318"]}, "name": "ECs5318", "id": "ECs5318"}, {"notes": {"original_bigg_ids": ["ECs5316"]}, "name": "ECs5316", "id": "ECs5316"}, {"notes": {"original_bigg_ids": ["dgoT"]}, "name": "None", "id": "dgoT"}, {"notes": {"original_bigg_ids": ["ECs4005"]}, "name": "ECs4005", "id": "ECs4005"}, {"notes": {"original_bigg_ids": ["ECs3649"]}, "name": "ECs3649", "id": "ECs3649"}, {"notes": {"original_bigg_ids": ["ECs0785"]}, "name": "ECs0785", "id": "ECs0785"}, {"notes": {"original_bigg_ids": ["ECs2850"]}, "name": "ECs2850", "id": "ECs2850"}, {"notes": {"original_bigg_ids": ["ECs0784"]}, "name": "ECs0784", "id": "ECs0784"}, {"notes": {"original_bigg_ids": ["ECs5101"]}, "name": "ECs5101", "id": "ECs5101"}, {"notes": {"original_bigg_ids": ["ECs2896"]}, "name": "ECs2896", "id": "ECs2896"}, {"notes": {"original_bigg_ids": ["ECs2897"]}, "name": "ECs2897", "id": "ECs2897"}, {"notes": {"original_bigg_ids": ["ECs2895"]}, "name": "ECs2895", "id": "ECs2895"}, {"notes": {"original_bigg_ids": ["ECs3975"]}, "name": "ECs3975", "id": "ECs3975"}, {"notes": {"original_bigg_ids": ["ECs1738"]}, "name": "ECs1738", "id": "ECs1738"}, {"notes": {"original_bigg_ids": ["ECs5208"]}, "name": "ECs5208", "id": "ECs5208"}, {"notes": {"original_bigg_ids": ["ECs5205"]}, "name": "ECs5205", "id": "ECs5205"}, {"notes": {"original_bigg_ids": ["ECs3041"]}, "name": "ECs3041", "id": "ECs3041"}, {"notes": {"original_bigg_ids": ["ECs5207"]}, "name": "ECs5207", "id": "ECs5207"}, {"notes": {"original_bigg_ids": ["ECs3042"]}, "name": "ECs3042", "id": "ECs3042"}, {"notes": {"original_bigg_ids": ["ECs3040"]}, "name": "ECs3040", "id": "ECs3040"}, {"notes": {"original_bigg_ids": ["ECs5206"]}, "name": "ECs5206", "id": "ECs5206"}, {"notes": {"original_bigg_ids": ["ECs3819"]}, "name": "ECs3819", "id": "ECs3819"}, {"notes": {"original_bigg_ids": ["ECs3362"]}, "name": "ECs3362", "id": "ECs3362"}, {"notes": {"original_bigg_ids": ["ECs2021"]}, "name": "ECs2021", "id": "ECs2021"}, {"notes": {"original_bigg_ids": ["ECs2857"]}, "name": "ECs2857", "id": "ECs2857"}, {"notes": {"original_bigg_ids": ["ECs4525"]}, "name": "ECs4525", "id": "ECs4525"}, {"notes": {"original_bigg_ids": ["ECs3644"]}, "name": "ECs3644", "id": "ECs3644"}, {"notes": {"original_bigg_ids": ["ECs2856"]}, "name": "ECs2856", "id": "ECs2856"}, {"notes": {"original_bigg_ids": ["ECs3329"]}, "name": "ECs3329", "id": "ECs3329"}, {"notes": {"original_bigg_ids": ["ECs4671"]}, "name": "ECs4671", "id": "ECs4671"}, {"notes": {"original_bigg_ids": ["ECs1875"]}, "name": "ECs1875", "id": "ECs1875"}, {"notes": {"original_bigg_ids": ["ECs1878"]}, "name": "ECs1878", "id": "ECs1878"}, {"notes": {"original_bigg_ids": ["ECs1874"]}, "name": "ECs1874", "id": "ECs1874"}, {"notes": {"original_bigg_ids": ["ECs4805"]}, "name": "ECs4805", "id": "ECs4805"}, {"notes": {"original_bigg_ids": ["ECs4277"]}, "name": "ECs4277", "id": "ECs4277"}, {"notes": {"original_bigg_ids": ["ECs0512"]}, "name": "ECs0512", "id": "ECs0512"}, {"notes": {"original_bigg_ids": ["ECs0917"]}, "name": "ECs0917", "id": "ECs0917"}, {"notes": {"original_bigg_ids": ["ECs0128"]}, "name": "ECs0128", "id": "ECs0128"}, {"notes": {"original_bigg_ids": ["ECs4285"]}, "name": "ECs4285", "id": "ECs4285"}, {"notes": {"original_bigg_ids": ["ECs4257"]}, "name": "ECs4257", "id": "ECs4257"}, {"notes": {"original_bigg_ids": ["ECs4259"]}, "name": "ECs4259", "id": "ECs4259"}, {"notes": {"original_bigg_ids": ["ECs4004"]}, "name": "ECs4004", "id": "ECs4004"}, {"notes": {"original_bigg_ids": ["ECs3648"]}, "name": "ECs3648", "id": "ECs3648"}, {"notes": {"original_bigg_ids": ["ECs3647"]}, "name": "ECs3647", "id": "ECs3647"}, {"notes": {"original_bigg_ids": ["ECs4274"]}, "name": "ECs4274", "id": "ECs4274"}, {"notes": {"original_bigg_ids": ["ECs4506"]}, "name": "ECs4506", "id": "ECs4506"}, {"notes": {"original_bigg_ids": ["ECs2329"]}, "name": "ECs2329", "id": "ECs2329"}, {"notes": {"original_bigg_ids": ["ECs4276"]}, "name": "ECs4276", "id": "ECs4276"}, {"notes": {"original_bigg_ids": ["ECs4275"]}, "name": "ECs4275", "id": "ECs4275"}, {"notes": {"original_bigg_ids": ["ECs4792"]}, "name": "ECs4792", "id": "ECs4792"}, {"notes": {"original_bigg_ids": ["ECs0710"]}, "name": "ECs0710", "id": "ECs0710"}, {"notes": {"original_bigg_ids": ["ECs0888"]}, "name": "ECs0888", "id": "ECs0888"}, {"notes": {"original_bigg_ids": ["ECs0889"]}, "name": "ECs0889", "id": "ECs0889"}, {"notes": {"original_bigg_ids": ["ECs0887"]}, "name": "ECs0887", "id": "ECs0887"}, {"notes": {"original_bigg_ids": ["ECs2894"]}, "name": "ECs2894", "id": "ECs2894"}, {"notes": {"original_bigg_ids": ["ECs0269"]}, "name": "ECs0269", "id": "ECs0269"}, {"notes": {"original_bigg_ids": ["ECs2097"]}, "name": "ECs2097", "id": "ECs2097"}, {"notes": {"original_bigg_ids": ["ECs3550"]}, "name": "ECs3550", "id": "ECs3550"}, {"notes": {"original_bigg_ids": ["ECs2098"]}, "name": "ECs2098", "id": "ECs2098"}, {"notes": {"original_bigg_ids": ["ECs2467"]}, "name": "ECs2467", "id": "ECs2467"}, {"notes": {"original_bigg_ids": ["ECs0538"]}, "name": "ECs0538", "id": "ECs0538"}, {"notes": {"original_bigg_ids": ["ECs2131"]}, "name": "ECs2131", "id": "ECs2131"}, {"notes": {"original_bigg_ids": ["ECs3196"]}, "name": "ECs3196", "id": "ECs3196"}, {"notes": {"original_bigg_ids": ["ECs4898"]}, "name": "ECs4898", "id": "ECs4898"}, {"notes": {"original_bigg_ids": ["ECs1715"]}, "name": "ECs1715", "id": "ECs1715"}, {"notes": {"original_bigg_ids": ["ECs3278"]}, "name": "ECs3278", "id": "ECs3278"}, {"notes": {"original_bigg_ids": ["ECs4529"]}, "name": "ECs4529", "id": "ECs4529"}, {"notes": {"original_bigg_ids": ["ECs0568"]}, "name": "ECs0568", "id": "ECs0568"}, {"notes": {"original_bigg_ids": ["ECs4852"]}, "name": "ECs4852", "id": "ECs4852"}, {"notes": {"original_bigg_ids": ["ECs4495"]}, "name": "ECs4495", "id": "ECs4495"}, {"notes": {"original_bigg_ids": ["ECs3125"]}, "name": "ECs3125", "id": "ECs3125"}, {"notes": {"original_bigg_ids": ["ECs0576"]}, "name": "ECs0576", "id": "ECs0576"}, {"notes": {"original_bigg_ids": ["ECs4002"]}, "name": "ECs4002", "id": "ECs4002"}, {"notes": {"original_bigg_ids": ["ECs3776"]}, "name": "ECs3776", "id": "ECs3776"}, {"notes": {"original_bigg_ids": ["ECs3774"]}, "name": "ECs3774", "id": "ECs3774"}, {"notes": {"original_bigg_ids": ["ECs3775"]}, "name": "ECs3775", "id": "ECs3775"}, {"notes": {"original_bigg_ids": ["ECs1410"]}, "name": "ECs1410", "id": "ECs1410"}, {"notes": {"original_bigg_ids": ["ECs4851"]}, "name": "ECs4851", "id": "ECs4851"}, {"notes": {"original_bigg_ids": ["ECs0208"]}, "name": "ECs0208", "id": "ECs0208"}, {"notes": {"original_bigg_ids": ["ECs4442"]}, "name": "ECs4442", "id": "ECs4442"}, {"notes": {"original_bigg_ids": ["ECs4443"]}, "name": "ECs4443", "id": "ECs4443"}, {"notes": {"original_bigg_ids": ["ECs2858"]}, "name": "ECs2858", "id": "ECs2858"}, {"notes": {"original_bigg_ids": ["ECs3935"]}, "name": "ECs3935", "id": "ECs3935"}, {"notes": {"original_bigg_ids": ["ECs0202"]}, "name": "ECs0202", "id": "ECs0202"}, {"notes": {"original_bigg_ids": ["ECs0108"]}, "name": "ECs0108", "id": "ECs0108"}, {"notes": {"original_bigg_ids": ["ECs3369"]}, "name": "ECs3369", "id": "ECs3369"}, {"notes": {"original_bigg_ids": ["ECs2830"]}, "name": "ECs2830", "id": "ECs2830"}, {"notes": {"original_bigg_ids": ["ECs4286"]}, "name": "ECs4286", "id": "ECs4286"}, {"notes": {"original_bigg_ids": ["ECs4295"]}, "name": "ECs4295", "id": "ECs4295"}, {"notes": {"original_bigg_ids": ["ECs3124"]}, "name": "ECs3124", "id": "ECs3124"}, {"notes": {"original_bigg_ids": ["ECs2363"]}, "name": "ECs2363", "id": "ECs2363"}, {"notes": {"original_bigg_ids": ["ECs4488"]}, "name": "ECs4488", "id": "ECs4488"}, {"notes": {"original_bigg_ids": ["ECs0929"]}, "name": "ECs0929", "id": "ECs0929"}, {"notes": {"original_bigg_ids": ["ECs0530"]}, "name": "ECs0530", "id": "ECs0530"}, {"notes": {"original_bigg_ids": ["ECs3873"]}, "name": "ECs3873", "id": "ECs3873"}, {"notes": {"original_bigg_ids": ["ECs4372"]}, "name": "ECs4372", "id": "ECs4372"}, {"notes": {"original_bigg_ids": ["ECs2417"]}, "name": "ECs2417", "id": "ECs2417"}, {"notes": {"original_bigg_ids": ["ECs4293"]}, "name": "ECs4293", "id": "ECs4293"}, {"notes": {"original_bigg_ids": ["ECs0908"]}, "name": "ECs0908", "id": "ECs0908"}, {"notes": {"original_bigg_ids": ["ECs0909"]}, "name": "ECs0909", "id": "ECs0909"}, {"notes": {"original_bigg_ids": ["ECs0911"]}, "name": "ECs0911", "id": "ECs0911"}, {"notes": {"original_bigg_ids": ["ECs0910"]}, "name": "ECs0910", "id": "ECs0910"}, {"notes": {"original_bigg_ids": ["ECs3823"]}, "name": "ECs3823", "id": "ECs3823"}, {"notes": {"original_bigg_ids": ["ECs3045"]}, "name": "ECs3045", "id": "ECs3045"}, {"notes": {"original_bigg_ids": ["ECs1850"]}, "name": "ECs1850", "id": "ECs1850"}, {"notes": {"original_bigg_ids": ["ECs4712"]}, "name": "ECs4712", "id": "ECs4712"}, {"notes": {"original_bigg_ids": ["ECs3756"]}, "name": "ECs3756", "id": "ECs3756"}, {"notes": {"original_bigg_ids": ["ECs0265"]}, "name": "ECs0265", "id": "ECs0265"}, {"notes": {"original_bigg_ids": ["ECs0129"]}, "name": "ECs0129", "id": "ECs0129"}, {"notes": {"original_bigg_ids": ["ECs3974"]}, "name": "ECs3974", "id": "ECs3974"}, {"notes": {"original_bigg_ids": ["ECs4797"]}, "name": "ECs4797", "id": "ECs4797"}, {"notes": {"original_bigg_ids": ["ECs1898"]}, "name": "ECs1898", "id": "ECs1898"}, {"notes": {"original_bigg_ids": ["ECs1041"]}, "name": "ECs1041", "id": "ECs1041"}, {"notes": {"original_bigg_ids": ["ECs0961"]}, "name": "ECs0961", "id": "ECs0961"}, {"notes": {"original_bigg_ids": ["ECs5023"]}, "name": "ECs5023", "id": "ECs5023"}, {"notes": {"original_bigg_ids": ["ECs0408"]}, "name": "ECs0408", "id": "ECs0408"}, {"notes": {"original_bigg_ids": ["ECs0392"]}, "name": "ECs0392", "id": "ECs0392"}, {"notes": {"original_bigg_ids": ["ECs0130"]}, "name": "ECs0130", "id": "ECs0130"}, {"notes": {"original_bigg_ids": ["ECs0482"]}, "name": "ECs0482", "id": "ECs0482"}, {"notes": {"original_bigg_ids": ["ECs4505"]}, "name": "ECs4505", "id": "ECs4505"}, {"notes": {"original_bigg_ids": ["ECs4499"]}, "name": "ECs4499", "id": "ECs4499"}, {"notes": {"original_bigg_ids": ["ECs4498"]}, "name": "ECs4498", "id": "ECs4498"}, {"notes": {"original_bigg_ids": ["ECs4507"]}, "name": "ECs4507", "id": "ECs4507"}, {"notes": {"original_bigg_ids": ["ECs2907"]}, "name": "ECs2907", "id": "ECs2907"}, {"notes": {"original_bigg_ids": ["ECs3268"]}, "name": "ECs3268", "id": "ECs3268"}, {"notes": {"original_bigg_ids": ["ECs0444"]}, "name": "ECs0444", "id": "ECs0444"}, {"notes": {"original_bigg_ids": ["ECs2821"]}, "name": "ECs2821", "id": "ECs2821"}, {"notes": {"original_bigg_ids": ["ECs2823"]}, "name": "ECs2823", "id": "ECs2823"}, {"notes": {"original_bigg_ids": ["ECs3376"]}, "name": "ECs3376", "id": "ECs3376"}, {"notes": {"original_bigg_ids": ["ECs3193"]}, "name": "ECs3193", "id": "ECs3193"}, {"notes": {"original_bigg_ids": ["ECs0116"]}, "name": "ECs0116", "id": "ECs0116"}, {"notes": {"original_bigg_ids": ["ECs0404"]}, "name": "ECs0404", "id": "ECs0404"}, {"notes": {"original_bigg_ids": ["ECs4735"]}, "name": "ECs4735", "id": "ECs4735"}, {"notes": {"original_bigg_ids": ["ECs3290"]}, "name": "ECs3290", "id": "ECs3290"}, {"notes": {"original_bigg_ids": ["ECs2906"]}, "name": "ECs2906", "id": "ECs2906"}, {"notes": {"original_bigg_ids": ["ECs4754"]}, "name": "ECs4754", "id": "ECs4754"}, {"notes": {"original_bigg_ids": ["ECs0891"]}, "name": "ECs0891", "id": "ECs0891"}, {"notes": {"original_bigg_ids": ["ECs0407"]}, "name": "ECs0407", "id": "ECs0407"}, {"notes": {"original_bigg_ids": ["ECs0146"]}, "name": "ECs0146", "id": "ECs0146"}, {"notes": {"original_bigg_ids": ["ECs0569"]}, "name": "ECs0569", "id": "ECs0569"}, {"notes": {"original_bigg_ids": ["ECs0003"]}, "name": "ECs0003", "id": "ECs0003"}, {"notes": {"original_bigg_ids": ["ECs4931"]}, "name": "ECs4931", "id": "ECs4931"}, {"notes": {"original_bigg_ids": ["ECs2822"]}, "name": "ECs2822", "id": "ECs2822"}, {"notes": {"original_bigg_ids": ["ECs3740"]}, "name": "ECs3740", "id": "ECs3740"}, {"notes": {"original_bigg_ids": ["ECs3739"]}, "name": "ECs3739", "id": "ECs3739"}, {"notes": {"original_bigg_ids": ["ECs3741"]}, "name": "ECs3741", "id": "ECs3741"}, {"notes": {"original_bigg_ids": ["ECs1129"]}, "name": "ECs1129", "id": "ECs1129"}, {"notes": {"original_bigg_ids": ["ECs3882"]}, "name": "ECs3882", "id": "ECs3882"}, {"notes": {"original_bigg_ids": ["ECs1130"]}, "name": "ECs1130", "id": "ECs1130"}, {"notes": {"original_bigg_ids": ["ECs3881"]}, "name": "ECs3881", "id": "ECs3881"}, {"notes": {"original_bigg_ids": ["ECs1128"]}, "name": "ECs1128", "id": "ECs1128"}, {"notes": {"original_bigg_ids": ["ECs3880"]}, "name": "ECs3880", "id": "ECs3880"}, {"notes": {"original_bigg_ids": ["ECs3879"]}, "name": "ECs3879", "id": "ECs3879"}, {"notes": {"original_bigg_ids": ["ECs3396"]}, "name": "ECs3396", "id": "ECs3396"}, {"notes": {"original_bigg_ids": ["ECs3395"]}, "name": "ECs3395", "id": "ECs3395"}, {"notes": {"original_bigg_ids": ["ECs4738"]}, "name": "ECs4738", "id": "ECs4738"}, {"notes": {"original_bigg_ids": ["ECs3394"]}, "name": "ECs3394", "id": "ECs3394"}, {"notes": {"original_bigg_ids": ["ECs1608"]}, "name": "ECs1608", "id": "ECs1608"}, {"notes": {"original_bigg_ids": ["ECs3153"]}, "name": "ECs3153", "id": "ECs3153"}, {"notes": {"original_bigg_ids": ["ECs0632"]}, "name": "ECs0632", "id": "ECs0632"}, {"notes": {"original_bigg_ids": ["ECs0634"]}, "name": "ECs0634", "id": "ECs0634"}, {"notes": {"original_bigg_ids": ["ECs4933"]}, "name": "ECs4933", "id": "ECs4933"}, {"notes": {"original_bigg_ids": ["ECs2824"]}, "name": "ECs2824", "id": "ECs2824"}, {"notes": {"original_bigg_ids": ["ECs2826"]}, "name": "ECs2826", "id": "ECs2826"}, {"notes": {"original_bigg_ids": ["ECs1834"]}, "name": "ECs1834", "id": "ECs1834"}, {"notes": {"original_bigg_ids": ["ECs4704"]}, "name": "ECs4704", "id": "ECs4704"}, {"notes": {"original_bigg_ids": ["ECs0029"]}, "name": "ECs0029", "id": "ECs0029"}, {"notes": {"original_bigg_ids": ["ECs0451"]}, "name": "ECs0451", "id": "ECs0451"}, {"notes": {"original_bigg_ids": ["ECs3370"]}, "name": "ECs3370", "id": "ECs3370"}, {"notes": {"original_bigg_ids": ["ECs4137"]}, "name": "ECs4137", "id": "ECs4137"}, {"notes": {"original_bigg_ids": ["acrF"]}, "name": "None", "id": "acrF"}, {"notes": {"original_bigg_ids": ["ECs4042"]}, "name": "ECs4042", "id": "ECs4042"}, {"notes": {"original_bigg_ids": ["ECs4620"]}, "name": "ECs4620", "id": "ECs4620"}, {"notes": {"original_bigg_ids": ["ECs3761"]}, "name": "ECs3761", "id": "ECs3761"}, {"notes": {"original_bigg_ids": ["ECs0077"]}, "name": "ECs0077", "id": "ECs0077"}, {"notes": {"original_bigg_ids": ["ECs0075"]}, "name": "ECs0075", "id": "ECs0075"}, {"notes": {"original_bigg_ids": ["ECs0076"]}, "name": "ECs0076", "id": "ECs0076"}, {"notes": {"original_bigg_ids": ["ECs0078"]}, "name": "ECs0078", "id": "ECs0078"}, {"notes": {"original_bigg_ids": ["ECs1001"]}, "name": "ECs1001", "id": "ECs1001"}, {"notes": {"original_bigg_ids": ["ECs4077"]}, "name": "ECs4077", "id": "ECs4077"}, {"notes": {"original_bigg_ids": ["ECs1720"]}, "name": "ECs1720", "id": "ECs1720"}, {"notes": {"original_bigg_ids": ["ECs5172"]}, "name": "ECs5172", "id": "ECs5172"}, {"notes": {"original_bigg_ids": ["ECs0725"]}, "name": "ECs0725", "id": "ECs0725"}, {"notes": {"original_bigg_ids": ["ECs0726"]}, "name": "ECs0726", "id": "ECs0726"}, {"notes": {"original_bigg_ids": ["ECs0724"]}, "name": "ECs0724", "id": "ECs0724"}, {"notes": {"original_bigg_ids": ["ECs4689"]}, "name": "ECs4689", "id": "ECs4689"}, {"notes": {"original_bigg_ids": ["ECs4155"]}, "name": "ECs4155", "id": "ECs4155"}, {"notes": {"original_bigg_ids": ["ECs1750"]}, "name": "ECs1750", "id": "ECs1750"}, {"notes": {"original_bigg_ids": ["ECs4777"]}, "name": "ECs4777", "id": "ECs4777"}, {"notes": {"original_bigg_ids": ["ECs1868"]}, "name": "ECs1868", "id": "ECs1868"}, {"notes": {"original_bigg_ids": ["ECs4201"]}, "name": "ECs4201", "id": "ECs4201"}, {"notes": {"original_bigg_ids": ["ECs0050"]}, "name": "ECs0050", "id": "ECs0050"}, {"notes": {"original_bigg_ids": ["ECs0922"]}, "name": "ECs0922", "id": "ECs0922"}, {"notes": {"original_bigg_ids": ["ECs0345"]}, "name": "ECs0345", "id": "ECs0345"}, {"notes": {"original_bigg_ids": ["ECs0344"]}, "name": "ECs0344", "id": "ECs0344"}, {"notes": {"original_bigg_ids": ["ECs0346"]}, "name": "ECs0346", "id": "ECs0346"}, {"notes": {"original_bigg_ids": ["ECs4483"]}, "name": "ECs4483", "id": "ECs4483"}, {"notes": {"original_bigg_ids": ["ECs3145"]}, "name": "ECs3145", "id": "ECs3145"}, {"notes": {"original_bigg_ids": ["ECs0397"]}, "name": "ECs0397", "id": "ECs0397"}, {"notes": {"original_bigg_ids": ["ECs3019"]}, "name": "ECs3019", "id": "ECs3019"}, {"notes": {"original_bigg_ids": ["ECs1905"]}, "name": "ECs1905", "id": "ECs1905"}, {"notes": {"original_bigg_ids": ["ECs5112"]}, "name": "ECs5112", "id": "ECs5112"}, {"notes": {"original_bigg_ids": ["ECs2343"]}, "name": "ECs2343", "id": "ECs2343"}, {"notes": {"original_bigg_ids": ["ECs0734"]}, "name": "ECs0734", "id": "ECs0734"}, {"notes": {"original_bigg_ids": ["ECs4368"]}, "name": "ECs4368", "id": "ECs4368"}, {"notes": {"original_bigg_ids": ["ECs3659"]}, "name": "ECs3659", "id": "ECs3659"}, {"notes": {"original_bigg_ids": ["ECs3062"]}, "name": "ECs3062", "id": "ECs3062"}, {"notes": {"original_bigg_ids": ["ECs0396"]}, "name": "ECs0396", "id": "ECs0396"}, {"notes": {"original_bigg_ids": ["ECs2002"]}, "name": "ECs2002", "id": "ECs2002"}, {"notes": {"original_bigg_ids": ["ECs3020"]}, "name": "ECs3020", "id": "ECs3020"}, {"notes": {"original_bigg_ids": ["ECs5036"]}, "name": "ECs5036", "id": "ECs5036"}, {"notes": {"original_bigg_ids": ["ECs0680"]}, "name": "ECs0680", "id": "ECs0680"}, {"notes": {"original_bigg_ids": ["ECs4305"]}, "name": "ECs4305", "id": "ECs4305"}, {"notes": {"original_bigg_ids": ["ECs2360"]}, "name": "ECs2360", "id": "ECs2360"}, {"notes": {"original_bigg_ids": ["ECs0661"]}, "name": "ECs0661", "id": "ECs0661"}, {"notes": {"original_bigg_ids": ["ECs5345"]}, "name": "ECs5345", "id": "ECs5345"}, {"notes": {"original_bigg_ids": ["ECs0668"]}, "name": "ECs0668", "id": "ECs0668"}, {"notes": {"original_bigg_ids": ["ECs0666"]}, "name": "ECs0666", "id": "ECs0666"}, {"notes": {"original_bigg_ids": ["ECs0184"]}, "name": "ECs0184", "id": "ECs0184"}, {"notes": {"original_bigg_ids": ["ECs0558"]}, "name": "ECs0558", "id": "ECs0558"}, {"notes": {"original_bigg_ids": ["ECs4755"]}, "name": "ECs4755", "id": "ECs4755"}, {"notes": {"original_bigg_ids": ["ECs0188"]}, "name": "ECs0188", "id": "ECs0188"}, {"notes": {"original_bigg_ids": ["ECs3048"]}, "name": "ECs3048", "id": "ECs3048"}, {"notes": {"original_bigg_ids": ["ECs4830"]}, "name": "ECs4830", "id": "ECs4830"}, {"notes": {"original_bigg_ids": ["rhaT"]}, "name": "None", "id": "rhaT"}, {"notes": {"original_bigg_ids": ["ECs4476"]}, "name": "ECs4476", "id": "ECs4476"}, {"notes": {"original_bigg_ids": ["ECs0855"]}, "name": "ECs0855", "id": "ECs0855"}, {"notes": {"original_bigg_ids": ["ECs2509"]}, "name": "ECs2509", "id": "ECs2509"}, {"notes": {"original_bigg_ids": ["ECs4932"]}, "name": "ECs4932", "id": "ECs4932"}, {"notes": {"original_bigg_ids": ["ECs2854"]}, "name": "ECs2854", "id": "ECs2854"}, {"notes": {"original_bigg_ids": ["ECs2319"]}, "name": "ECs2319", "id": "ECs2319"}, {"notes": {"original_bigg_ids": ["ECs5282"]}, "name": "ECs5282", "id": "ECs5282"}, {"notes": {"original_bigg_ids": ["ECs0387"]}, "name": "ECs0387", "id": "ECs0387"}, {"notes": {"original_bigg_ids": ["ECs0385"]}, "name": "ECs0385", "id": "ECs0385"}, {"notes": {"original_bigg_ids": ["ECs0386"]}, "name": "ECs0386", "id": "ECs0386"}, {"notes": {"original_bigg_ids": ["ECs1470"]}, "name": "ECs1470", "id": "ECs1470"}, {"notes": {"original_bigg_ids": ["ECs3387"]}, "name": "ECs3387", "id": "ECs3387"}, {"notes": {"original_bigg_ids": ["ECs0088"]}, "name": "ECs0088", "id": "ECs0088"}, {"notes": {"original_bigg_ids": ["ECs0673"]}, "name": "ECs0673", "id": "ECs0673"}, {"notes": {"original_bigg_ids": ["ECs0153"]}, "name": "ECs0153", "id": "ECs0153"}, {"notes": {"original_bigg_ids": ["ECs4238"]}, "name": "ECs4238", "id": "ECs4238"}, {"notes": {"original_bigg_ids": ["ECs0670"]}, "name": "ECs0670", "id": "ECs0670"}, {"notes": {"original_bigg_ids": ["ECs4061"]}, "name": "ECs4061", "id": "ECs4061"}, {"notes": {"original_bigg_ids": ["ECs0919"]}, "name": "ECs0919", "id": "ECs0919"}, {"notes": {"original_bigg_ids": ["ECs2812"]}, "name": "ECs2812", "id": "ECs2812"}, {"notes": {"original_bigg_ids": ["ECs3021"]}, "name": "ECs3021", "id": "ECs3021"}, {"notes": {"original_bigg_ids": ["ECs3212"]}, "name": "ECs3212", "id": "ECs3212"}, {"notes": {"original_bigg_ids": ["ECs4109"]}, "name": "ECs4109", "id": "ECs4109"}, {"notes": {"original_bigg_ids": ["ECs3099"]}, "name": "ECs3099", "id": "ECs3099"}, {"notes": {"original_bigg_ids": ["ECs2083"]}, "name": "ECs2083", "id": "ECs2083"}, {"notes": {"original_bigg_ids": ["ECs3325"]}, "name": "ECs3325", "id": "ECs3325"}, {"notes": {"original_bigg_ids": ["ECs3377"]}, "name": "ECs3377", "id": "ECs3377"}, {"notes": {"original_bigg_ids": ["ECs3600"]}, "name": "ECs3600", "id": "ECs3600"}, {"notes": {"original_bigg_ids": ["ECs5102"]}, "name": "ECs5102", "id": "ECs5102"}, {"notes": {"original_bigg_ids": ["ECs3601"]}, "name": "ECs3601", "id": "ECs3601"}, {"notes": {"original_bigg_ids": ["ECs3818"]}, "name": "ECs3818", "id": "ECs3818"}, {"notes": {"original_bigg_ids": ["ECs0200"]}, "name": "ECs0200", "id": "ECs0200"}, {"notes": {"original_bigg_ids": ["ECs0199"]}, "name": "ECs0199", "id": "ECs0199"}, {"notes": {"original_bigg_ids": ["ECs0201"]}, "name": "ECs0201", "id": "ECs0201"}, {"notes": {"original_bigg_ids": ["ECs4759"]}, "name": "ECs4759", "id": "ECs4759"}, {"notes": {"original_bigg_ids": ["ECs4937"]}, "name": "ECs4937", "id": "ECs4937"}, {"notes": {"original_bigg_ids": ["ECs5197"]}, "name": "ECs5197", "id": "ECs5197"}, {"notes": {"original_bigg_ids": ["ECs2487"]}, "name": "ECs2487", "id": "ECs2487"}, {"notes": {"original_bigg_ids": ["ECs2920"]}, "name": "ECs2920", "id": "ECs2920"}, {"notes": {"original_bigg_ids": ["ECs5219"]}, "name": "ECs5219", "id": "ECs5219"}, {"notes": {"original_bigg_ids": ["ECs1047"]}, "name": "ECs1047", "id": "ECs1047"}, {"notes": {"original_bigg_ids": ["ECs0453"]}, "name": "ECs0453", "id": "ECs0453"}, {"notes": {"original_bigg_ids": ["ECs1687"]}, "name": "ECs1687", "id": "ECs1687"}, {"notes": {"original_bigg_ids": ["ECs5350"]}, "name": "ECs5350", "id": "ECs5350"}, {"notes": {"original_bigg_ids": ["ECs3673"]}, "name": "ECs3673", "id": "ECs3673"}, {"notes": {"original_bigg_ids": ["ECs3424"]}, "name": "ECs3424", "id": "ECs3424"}, {"notes": {"original_bigg_ids": ["ECs3839"]}, "name": "ECs3839", "id": "ECs3839"}, {"notes": {"original_bigg_ids": ["ECs3558"]}, "name": "ECs3558", "id": "ECs3558"}, {"notes": {"original_bigg_ids": ["ECs3789"]}, "name": "ECs3789", "id": "ECs3789"}, {"notes": {"original_bigg_ids": ["ECs3787"]}, "name": "ECs3787", "id": "ECs3787"}, {"notes": {"original_bigg_ids": ["ECs4475"]}, "name": "ECs4475", "id": "ECs4475"}, {"notes": {"original_bigg_ids": ["ECs5281"]}, "name": "ECs5281", "id": "ECs5281"}, {"notes": {"original_bigg_ids": ["ECs0862"]}, "name": "ECs0862", "id": "ECs0862"}, {"notes": {"original_bigg_ids": ["ECs4508"]}, "name": "ECs4508", "id": "ECs4508"}, {"notes": {"original_bigg_ids": ["ECs0792"]}, "name": "ECs0792", "id": "ECs0792"}, {"notes": {"original_bigg_ids": ["ECs0793"]}, "name": "ECs0793", "id": "ECs0793"}, {"notes": {"original_bigg_ids": ["ECs3295"]}, "name": "ECs3295", "id": "ECs3295"}, {"notes": {"original_bigg_ids": ["ECs3293"]}, "name": "ECs3293", "id": "ECs3293"}, {"notes": {"original_bigg_ids": ["ECs3294"]}, "name": "ECs3294", "id": "ECs3294"}, {"notes": {"original_bigg_ids": ["ECs3296"]}, "name": "ECs3296", "id": "ECs3296"}, {"notes": {"original_bigg_ids": ["ECs0791"]}, "name": "ECs0791", "id": "ECs0791"}, {"notes": {"original_bigg_ids": ["ECs4842"]}, "name": "ECs4842", "id": "ECs4842"}, {"notes": {"original_bigg_ids": ["ECs3750"]}, "name": "ECs3750", "id": "ECs3750"}, {"notes": {"original_bigg_ids": ["ECs0138"]}, "name": "ECs0138", "id": "ECs0138"}, {"notes": {"original_bigg_ids": ["ECs0009"]}, "name": "ECs0009", "id": "ECs0009"}, {"notes": {"original_bigg_ids": ["ECs3385"]}, "name": "ECs3385", "id": "ECs3385"}, {"notes": {"original_bigg_ids": ["ECs1447"]}, "name": "ECs1447", "id": "ECs1447"}, {"notes": {"original_bigg_ids": ["ECs0863"]}, "name": "ECs0863", "id": "ECs0863"}, {"notes": {"original_bigg_ids": ["ECs0904"]}, "name": "ECs0904", "id": "ECs0904"}, {"notes": {"original_bigg_ids": ["ECs1254"]}, "name": "ECs1254", "id": "ECs1254"}, {"notes": {"original_bigg_ids": ["ECs0591"]}, "name": "ECs0591", "id": "ECs0591"}, {"notes": {"original_bigg_ids": ["ECs4870"]}, "name": "ECs4870", "id": "ECs4870"}, {"notes": {"original_bigg_ids": ["ECs1437"]}, "name": "ECs1437", "id": "ECs1437"}, {"notes": {"original_bigg_ids": ["ECs4919"]}, "name": "ECs4919", "id": "ECs4919"}, {"notes": {"original_bigg_ids": ["ECs3283"]}, "name": "ECs3283", "id": "ECs3283"}, {"notes": {"original_bigg_ids": ["ECs1487"]}, "name": "ECs1487", "id": "ECs1487"}, {"notes": {"original_bigg_ids": ["ECs3168"]}, "name": "ECs3168", "id": "ECs3168"}, {"notes": {"original_bigg_ids": ["ECs3164"]}, "name": "ECs3164", "id": "ECs3164"}, {"notes": {"original_bigg_ids": ["ECs3169"]}, "name": "ECs3169", "id": "ECs3169"}, {"notes": {"original_bigg_ids": ["ECs3162"]}, "name": "ECs3162", "id": "ECs3162"}, {"notes": {"original_bigg_ids": ["ECs3165"]}, "name": "ECs3165", "id": "ECs3165"}, {"notes": {"original_bigg_ids": ["ECs3172"]}, "name": "ECs3172", "id": "ECs3172"}, {"notes": {"original_bigg_ids": ["ECs3170"]}, "name": "ECs3170", "id": "ECs3170"}, {"notes": {"original_bigg_ids": ["ECs3167"]}, "name": "ECs3167", "id": "ECs3167"}, {"notes": {"original_bigg_ids": ["ECs3166"]}, "name": "ECs3166", "id": "ECs3166"}, {"notes": {"original_bigg_ids": ["ECs3161"]}, "name": "ECs3161", "id": "ECs3161"}, {"notes": {"original_bigg_ids": ["ECs3160"]}, "name": "ECs3160", "id": "ECs3160"}, {"notes": {"original_bigg_ids": ["ECs3163"]}, "name": "ECs3163", "id": "ECs3163"}, {"notes": {"original_bigg_ids": ["ECs3171"]}, "name": "ECs3171", "id": "ECs3171"}, {"notes": {"original_bigg_ids": ["ECs3477"]}, "name": "ECs3477", "id": "ECs3477"}, {"notes": {"original_bigg_ids": ["ECs3910"]}, "name": "ECs3910", "id": "ECs3910"}, {"notes": {"original_bigg_ids": ["ECs2446"]}, "name": "ECs2446", "id": "ECs2446"}, {"notes": {"original_bigg_ids": ["ECs2309"]}, "name": "ECs2309", "id": "ECs2309"}, {"notes": {"original_bigg_ids": ["ECs2308"]}, "name": "ECs2308", "id": "ECs2308"}, {"notes": {"original_bigg_ids": ["ECs4891"]}, "name": "ECs4891", "id": "ECs4891"}, {"notes": {"original_bigg_ids": ["ECs1014"]}, "name": "ECs1014", "id": "ECs1014"}, {"notes": {"original_bigg_ids": ["ECs1681"]}, "name": "ECs1681", "id": "ECs1681"}, {"notes": {"original_bigg_ids": ["ECs0017"]}, "name": "ECs0017", "id": "ECs0017"}, {"notes": {"original_bigg_ids": ["ECs3380"]}, "name": "ECs3380", "id": "ECs3380"}, {"notes": {"original_bigg_ids": ["ECs0505"]}, "name": "ECs0505", "id": "ECs0505"}, {"notes": {"original_bigg_ids": ["ECs3566"]}, "name": "ECs3566", "id": "ECs3566"}, {"notes": {"original_bigg_ids": ["ECs3567"]}, "name": "ECs3567", "id": "ECs3567"}, {"notes": {"original_bigg_ids": ["ECs4346"]}, "name": "ECs4346", "id": "ECs4346"}, {"notes": {"original_bigg_ids": ["ECs4347"]}, "name": "ECs4347", "id": "ECs4347"}, {"notes": {"original_bigg_ids": ["ECs4345"]}, "name": "ECs4345", "id": "ECs4345"}, {"notes": {"original_bigg_ids": ["ECs4343"]}, "name": "ECs4343", "id": "ECs4343"}, {"notes": {"original_bigg_ids": ["ECs4344"]}, "name": "ECs4344", "id": "ECs4344"}, {"notes": {"original_bigg_ids": ["ECs0677"]}, "name": "ECs0677", "id": "ECs0677"}, {"notes": {"original_bigg_ids": ["ECs5348"]}, "name": "ECs5348", "id": "ECs5348"}, {"notes": {"original_bigg_ids": ["ECs0779"]}, "name": "ECs0779", "id": "ECs0779"}, {"notes": {"original_bigg_ids": ["ECs2475"]}, "name": "ECs2475", "id": "ECs2475"}, {"notes": {"original_bigg_ids": ["ECs2786"]}, "name": "ECs2786", "id": "ECs2786"}, {"notes": {"original_bigg_ids": ["ECs0113"]}, "name": "ECs0113", "id": "ECs0113"}, {"notes": {"original_bigg_ids": ["ECs4218"]}, "name": "ECs4218", "id": "ECs4218"}, {"notes": {"original_bigg_ids": ["ECs1728"]}, "name": "ECs1728", "id": "ECs1728"}, {"notes": {"original_bigg_ids": ["ECs3091"]}, "name": "ECs3091", "id": "ECs3091"}, {"notes": {"original_bigg_ids": ["ECs3095"]}, "name": "ECs3095", "id": "ECs3095"}, {"notes": {"original_bigg_ids": ["ECs3092"]}, "name": "ECs3092", "id": "ECs3092"}, {"notes": {"original_bigg_ids": ["ECs3094"]}, "name": "ECs3094", "id": "ECs3094"}, {"notes": {"original_bigg_ids": ["ECs3093"]}, "name": "ECs3093", "id": "ECs3093"}, {"notes": {"original_bigg_ids": ["ECs1731"]}, "name": "ECs1731", "id": "ECs1731"}, {"notes": {"original_bigg_ids": ["ECs1730"]}, "name": "ECs1730", "id": "ECs1730"}, {"notes": {"original_bigg_ids": ["ECs1732"]}, "name": "ECs1732", "id": "ECs1732"}, {"notes": {"original_bigg_ids": ["ECs2069"]}, "name": "ECs2069", "id": "ECs2069"}, {"notes": {"original_bigg_ids": ["ECs2068"]}, "name": "ECs2068", "id": "ECs2068"}, {"notes": {"original_bigg_ids": ["ECs1729"]}, "name": "ECs1729", "id": "ECs1729"}, {"notes": {"original_bigg_ids": ["ECs3418"]}, "name": "ECs3418", "id": "ECs3418"}, {"notes": {"original_bigg_ids": ["ECs3598"]}, "name": "ECs3598", "id": "ECs3598"}, {"notes": {"original_bigg_ids": ["ECs3175"]}, "name": "ECs3175", "id": "ECs3175"}, {"notes": {"original_bigg_ids": ["ECs5332"]}, "name": "ECs5332", "id": "ECs5332"}, {"notes": {"original_bigg_ids": ["ECs0533"]}, "name": "ECs0533", "id": "ECs0533"}, {"notes": {"original_bigg_ids": ["ECs5140"]}, "name": "ECs5140", "id": "ECs5140"}, {"notes": {"original_bigg_ids": ["ECs0689"]}, "name": "ECs0689", "id": "ECs0689"}, {"notes": {"original_bigg_ids": ["ECs5352"]}, "name": "ECs5352", "id": "ECs5352"}, {"notes": {"original_bigg_ids": ["ECs1136"]}, "name": "ECs1136", "id": "ECs1136"}, {"notes": {"original_bigg_ids": ["ECs3641"]}, "name": "ECs3641", "id": "ECs3641"}, {"notes": {"original_bigg_ids": ["ECs3830"]}, "name": "ECs3830", "id": "ECs3830"}, {"notes": {"original_bigg_ids": ["ECs2465"]}, "name": "ECs2465", "id": "ECs2465"}, {"notes": {"original_bigg_ids": ["ECs0164"]}, "name": "ECs0164", "id": "ECs0164"}, {"notes": {"original_bigg_ids": ["ECs4217"]}, "name": "ECs4217", "id": "ECs4217"}, {"notes": {"original_bigg_ids": ["ECs4216"]}, "name": "ECs4216", "id": "ECs4216"}, {"notes": {"original_bigg_ids": ["ECs5054"]}, "name": "ECs5054", "id": "ECs5054"}, {"notes": {"original_bigg_ids": ["ECs5055"]}, "name": "ECs5055", "id": "ECs5055"}, {"notes": {"original_bigg_ids": ["ECs5052"]}, "name": "ECs5052", "id": "ECs5052"}, {"notes": {"original_bigg_ids": ["ECs5053"]}, "name": "ECs5053", "id": "ECs5053"}, {"notes": {"original_bigg_ids": ["wbbJ"]}, "name": "None", "id": "wbbJ"}, {"notes": {"original_bigg_ids": ["ECs3445"]}, "name": "ECs3445", "id": "ECs3445"}, {"notes": {"original_bigg_ids": ["ECs0986"]}, "name": "ECs0986", "id": "ECs0986"}, {"notes": {"original_bigg_ids": ["ECs3994"]}, "name": "ECs3994", "id": "ECs3994"}, {"notes": {"original_bigg_ids": ["ECs0985"]}, "name": "ECs0985", "id": "ECs0985"}, {"notes": {"original_bigg_ids": ["ECs5231"]}, "name": "ECs5231", "id": "ECs5231"}, {"notes": {"original_bigg_ids": ["ECs4066"]}, "name": "ECs4066", "id": "ECs4066"}, {"notes": {"original_bigg_ids": ["ECs0990"]}, "name": "ECs0990", "id": "ECs0990"}, {"notes": {"original_bigg_ids": ["ECs0700"]}, "name": "ECs0700", "id": "ECs0700"}, {"notes": {"original_bigg_ids": ["ECs1854"]}, "name": "ECs1854", "id": "ECs1854"}, {"notes": {"original_bigg_ids": ["ECs3778"]}, "name": "ECs3778", "id": "ECs3778"}, {"notes": {"original_bigg_ids": ["ECs0405"]}, "name": "ECs0405", "id": "ECs0405"}, {"notes": {"original_bigg_ids": ["ECs4771"]}, "name": "ECs4771", "id": "ECs4771"}, {"notes": {"original_bigg_ids": ["ECs3195"]}, "name": "ECs3195", "id": "ECs3195"}, {"notes": {"original_bigg_ids": ["ECs4765"]}, "name": "ECs4765", "id": "ECs4765"}, {"notes": {"original_bigg_ids": ["ECs3841"]}, "name": "ECs3841", "id": "ECs3841"}, {"notes": {"original_bigg_ids": ["ECs4517"]}, "name": "ECs4517", "id": "ECs4517"}, {"notes": {"original_bigg_ids": ["ECs3253"]}, "name": "ECs3253", "id": "ECs3253"}, {"notes": {"original_bigg_ids": ["ECs1260"]}, "name": "ECs1260", "id": "ECs1260"}, {"notes": {"original_bigg_ids": ["ECs0437"]}, "name": "ECs0437", "id": "ECs0437"}, {"notes": {"original_bigg_ids": ["ECs0137"]}, "name": "ECs0137", "id": "ECs0137"}, {"notes": {"original_bigg_ids": ["ECs1851"]}, "name": "ECs1851", "id": "ECs1851"}, {"notes": {"original_bigg_ids": ["ECs0091"]}, "name": "ECs0091", "id": "ECs0091"}, {"notes": {"original_bigg_ids": ["ECs3617"]}, "name": "ECs3617", "id": "ECs3617"}, {"notes": {"original_bigg_ids": ["dosP"]}, "name": "None", "id": "dosP"}, {"notes": {"original_bigg_ids": ["ECs0118"]}, "name": "ECs0118", "id": "ECs0118"}, {"notes": {"original_bigg_ids": ["ECs0119"]}, "name": "ECs0119", "id": "ECs0119"}, {"notes": {"original_bigg_ids": ["ECs2347"]}, "name": "ECs2347", "id": "ECs2347"}, {"notes": {"original_bigg_ids": ["ECs0057"]}, "name": "ECs0057", "id": "ECs0057"}, {"notes": {"original_bigg_ids": ["ECs3430"]}, "name": "ECs3430", "id": "ECs3430"}, {"notes": {"original_bigg_ids": ["ECs0794"]}, "name": "ECs0794", "id": "ECs0794"}, {"notes": {"original_bigg_ids": ["ECs3204"]}, "name": "ECs3204", "id": "ECs3204"}, {"notes": {"original_bigg_ids": ["ECs4425"]}, "name": "ECs4425", "id": "ECs4425"}, {"notes": {"original_bigg_ids": ["ECs4841"]}, "name": "ECs4841", "id": "ECs4841"}, {"notes": {"original_bigg_ids": ["ECs2429"]}, "name": "ECs2429", "id": "ECs2429"}, {"notes": {"original_bigg_ids": ["ECs4881"]}, "name": "ECs4881", "id": "ECs4881"}, {"notes": {"original_bigg_ids": ["ECs4880"]}, "name": "ECs4880", "id": "ECs4880"}, {"notes": {"original_bigg_ids": ["ECs4055"]}, "name": "ECs4055", "id": "ECs4055"}, {"notes": {"original_bigg_ids": ["ECs3784"]}, "name": "ECs3784", "id": "ECs3784"}, {"notes": {"original_bigg_ids": ["ECs5008"]}, "name": "ECs5008", "id": "ECs5008"}, {"notes": {"original_bigg_ids": ["ECs3797"]}, "name": "ECs3797", "id": "ECs3797"}, {"notes": {"original_bigg_ids": ["ECs0795"]}, "name": "ECs0795", "id": "ECs0795"}, {"notes": {"original_bigg_ids": ["ECs4227"]}, "name": "ECs4227", "id": "ECs4227"}, {"notes": {"original_bigg_ids": ["ECs5353"]}, "name": "ECs5353", "id": "ECs5353"}, {"notes": {"original_bigg_ids": ["ECs4490"]}, "name": "ECs4490", "id": "ECs4490"}, {"notes": {"original_bigg_ids": ["ECs0783"]}, "name": "ECs0783", "id": "ECs0783"}, {"notes": {"original_bigg_ids": ["ECs3552"]}, "name": "ECs3552", "id": "ECs3552"}, {"notes": {"original_bigg_ids": ["ECs0719"]}, "name": "ECs0719", "id": "ECs0719"}, {"notes": {"original_bigg_ids": ["ECs0471"]}, "name": "ECs0471", "id": "ECs0471"}, {"notes": {"original_bigg_ids": ["ECs2650"]}, "name": "ECs2650", "id": "ECs2650"}, {"notes": {"original_bigg_ids": ["ECs3086"]}, "name": "ECs3086", "id": "ECs3086"}, {"notes": {"original_bigg_ids": ["ECs3088"]}, "name": "ECs3088", "id": "ECs3088"}, {"notes": {"original_bigg_ids": ["ECs3087"]}, "name": "ECs3087", "id": "ECs3087"}, {"notes": {"original_bigg_ids": ["ECs3090"]}, "name": "ECs3090", "id": "ECs3090"}, {"notes": {"original_bigg_ids": ["ECs3089"]}, "name": "ECs3089", "id": "ECs3089"}, {"notes": {"original_bigg_ids": ["ECs2420"]}, "name": "ECs2420", "id": "ECs2420"}, {"notes": {"original_bigg_ids": ["ECs2421"]}, "name": "ECs2421", "id": "ECs2421"}, {"notes": {"original_bigg_ids": ["ECs0614"]}, "name": "ECs0614", "id": "ECs0614"}, {"notes": {"original_bigg_ids": ["ECs2077"]}, "name": "ECs2077", "id": "ECs2077"}, {"notes": {"original_bigg_ids": ["ECs4365"]}, "name": "ECs4365", "id": "ECs4365"}, {"notes": {"original_bigg_ids": ["ECs3872"]}, "name": "ECs3872", "id": "ECs3872"}, {"notes": {"original_bigg_ids": ["ECs4663"]}, "name": "ECs4663", "id": "ECs4663"}, {"notes": {"original_bigg_ids": ["ECs4664"]}, "name": "ECs4664", "id": "ECs4664"}, {"notes": {"original_bigg_ids": ["ECs4662"]}, "name": "ECs4662", "id": "ECs4662"}, {"notes": {"original_bigg_ids": ["ECs4661"]}, "name": "ECs4661", "id": "ECs4661"}, {"notes": {"original_bigg_ids": ["ECs4751"]}, "name": "ECs4751", "id": "ECs4751"}, {"notes": {"original_bigg_ids": ["ECs2853"]}, "name": "ECs2853", "id": "ECs2853"}, {"notes": {"original_bigg_ids": ["ECs4255"]}, "name": "ECs4255", "id": "ECs4255"}, {"notes": {"original_bigg_ids": ["ECs4901"]}, "name": "ECs4901", "id": "ECs4901"}, {"notes": {"original_bigg_ids": ["ECs4130"]}, "name": "ECs4130", "id": "ECs4130"}, {"notes": {"original_bigg_ids": ["ECs1256"]}, "name": "ECs1256", "id": "ECs1256"}, {"notes": {"original_bigg_ids": ["ECs2000"]}, "name": "ECs2000", "id": "ECs2000"}, {"notes": {"original_bigg_ids": ["ECs0957"]}, "name": "ECs0957", "id": "ECs0957"}, {"notes": {"original_bigg_ids": ["ECs5204"]}, "name": "ECs5204", "id": "ECs5204"}, {"notes": {"original_bigg_ids": ["ECs3364"]}, "name": "ECs3364", "id": "ECs3364"}, {"notes": {"original_bigg_ids": ["ECs1261"]}, "name": "ECs1261", "id": "ECs1261"}, {"notes": {"original_bigg_ids": ["ECs0423"]}, "name": "ECs0423", "id": "ECs0423"}, {"notes": {"original_bigg_ids": ["ECs4885"]}, "name": "ECs4885", "id": "ECs4885"}, {"notes": {"original_bigg_ids": ["ECs4514"]}, "name": "ECs4514", "id": "ECs4514"}, {"notes": {"original_bigg_ids": ["ECs4245"]}, "name": "ECs4245", "id": "ECs4245"}, {"notes": {"original_bigg_ids": ["ECs3790"]}, "name": "ECs3790", "id": "ECs3790"}, {"notes": {"original_bigg_ids": ["ECs3363"]}, "name": "ECs3363", "id": "ECs3363"}, {"notes": {"original_bigg_ids": ["ECs5342"]}, "name": "ECs5342", "id": "ECs5342"}, {"notes": {"original_bigg_ids": ["ECs4778"]}, "name": "ECs4778", "id": "ECs4778"}, {"notes": {"original_bigg_ids": ["ECs3402"]}, "name": "ECs3402", "id": "ECs3402"}, {"notes": {"original_bigg_ids": ["ECs2409"]}, "name": "ECs2409", "id": "ECs2409"}, {"notes": {"original_bigg_ids": ["ECs0433"]}, "name": "ECs0433", "id": "ECs0433"}, {"notes": {"original_bigg_ids": ["ECs4928"]}, "name": "ECs4928", "id": "ECs4928"}, {"notes": {"original_bigg_ids": ["ECs3361"]}, "name": "ECs3361", "id": "ECs3361"}, {"notes": {"original_bigg_ids": ["ECs2827"]}, "name": "ECs2827", "id": "ECs2827"}, {"notes": {"original_bigg_ids": ["ECs3338"]}, "name": "ECs3338", "id": "ECs3338"}, {"notes": {"original_bigg_ids": ["ECs3423"]}, "name": "ECs3423", "id": "ECs3423"}, {"notes": {"original_bigg_ids": ["ECs2825"]}, "name": "ECs2825", "id": "ECs2825"}, {"notes": {"original_bigg_ids": ["ECs0196"]}, "name": "ECs0196", "id": "ECs0196"}, {"notes": {"original_bigg_ids": ["ECs1712"]}, "name": "ECs1712", "id": "ECs1712"}, {"notes": {"original_bigg_ids": ["ECs0991"]}, "name": "ECs0991", "id": "ECs0991"}, {"notes": {"original_bigg_ids": ["ECs5139"]}, "name": "ECs5139", "id": "ECs5139"}, {"notes": {"original_bigg_ids": ["ECs5346"]}, "name": "ECs5346", "id": "ECs5346"}, {"notes": {"original_bigg_ids": ["ECs3452"]}, "name": "ECs3452", "id": "ECs3452"}, {"notes": {"original_bigg_ids": ["ECs3181"]}, "name": "ECs3181", "id": "ECs3181"}, {"notes": {"original_bigg_ids": ["ECs3320"]}, "name": "ECs3320", "id": "ECs3320"}, {"notes": {"original_bigg_ids": ["ECs4509"]}, "name": "ECs4509", "id": "ECs4509"}, {"notes": {"original_bigg_ids": ["ECs0720"]}, "name": "ECs0720", "id": "ECs0720"}, {"notes": {"original_bigg_ids": ["ECs3955"]}, "name": "ECs3955", "id": "ECs3955"}, {"notes": {"original_bigg_ids": ["ECs2044"]}, "name": "ECs2044", "id": "ECs2044"}, {"notes": {"original_bigg_ids": ["ECs0936"]}, "name": "ECs0936", "id": "ECs0936"}, {"notes": {"original_bigg_ids": ["ECs0935"]}, "name": "ECs0935", "id": "ECs0935"}, {"notes": {"original_bigg_ids": ["ECs1500"]}, "name": "ECs1500", "id": "ECs1500"}, {"notes": {"original_bigg_ids": ["ECs2045"]}, "name": "ECs2045", "id": "ECs2045"}, {"notes": {"original_bigg_ids": ["ECs1571"]}, "name": "ECs1571", "id": "ECs1571"}, {"notes": {"original_bigg_ids": ["ECs1499"]}, "name": "ECs1499", "id": "ECs1499"}, {"notes": {"original_bigg_ids": ["ECs0934"]}, "name": "ECs0934", "id": "ECs0934"}, {"notes": {"original_bigg_ids": ["ECs1570"]}, "name": "ECs1570", "id": "ECs1570"}, {"notes": {"original_bigg_ids": ["ECs0937"]}, "name": "ECs0937", "id": "ECs0937"}, {"notes": {"original_bigg_ids": ["ECs2046"]}, "name": "ECs2046", "id": "ECs2046"}, {"notes": {"original_bigg_ids": ["ECs2047"]}, "name": "ECs2047", "id": "ECs2047"}, {"notes": {"original_bigg_ids": ["ECs1873"]}, "name": "ECs1873", "id": "ECs1873"}, {"notes": {"original_bigg_ids": ["ECs2345"]}, "name": "ECs2345", "id": "ECs2345"}, {"notes": {"original_bigg_ids": ["ECs4756"]}, "name": "ECs4756", "id": "ECs4756"}, {"notes": {"original_bigg_ids": ["ECs2383"]}, "name": "ECs2383", "id": "ECs2383"}, {"notes": {"original_bigg_ids": ["ECs2564"]}, "name": "ECs2564", "id": "ECs2564"}, {"notes": {"original_bigg_ids": ["ECs4761"]}, "name": "ECs4761", "id": "ECs4761"}, {"notes": {"original_bigg_ids": ["ECs1258"]}, "name": "ECs1258", "id": "ECs1258"}, {"notes": {"original_bigg_ids": ["ECs1253"]}, "name": "ECs1253", "id": "ECs1253"}, {"notes": {"original_bigg_ids": ["ECs3911"]}, "name": "ECs3911", "id": "ECs3911"}, {"notes": {"original_bigg_ids": ["ECs2399"]}, "name": "ECs2399", "id": "ECs2399"}, {"notes": {"original_bigg_ids": ["ECs0778"]}, "name": "ECs0778", "id": "ECs0778"}, {"notes": {"original_bigg_ids": ["ECs5077"]}, "name": "ECs5077", "id": "ECs5077"}, {"notes": {"original_bigg_ids": ["ECs2371"]}, "name": "ECs2371", "id": "ECs2371"}, {"notes": {"original_bigg_ids": ["ECs0468"]}, "name": "ECs0468", "id": "ECs0468"}, {"notes": {"original_bigg_ids": ["ECs4694"]}, "name": "ECs4694", "id": "ECs4694"}, {"notes": {"original_bigg_ids": ["ECs0067"]}, "name": "ECs0067", "id": "ECs0067"}, {"notes": {"original_bigg_ids": ["ECs5174"]}, "name": "ECs5174", "id": "ECs5174"}, {"notes": {"original_bigg_ids": ["ECs0065"]}, "name": "ECs0065", "id": "ECs0065"}, {"notes": {"original_bigg_ids": ["ECs3549"]}, "name": "ECs3549", "id": "ECs3549"}, {"notes": {"original_bigg_ids": ["ECs4690"]}, "name": "ECs4690", "id": "ECs4690"}, {"notes": {"original_bigg_ids": ["ECs4693"]}, "name": "ECs4693", "id": "ECs4693"}, {"notes": {"original_bigg_ids": ["ECs4691"]}, "name": "ECs4691", "id": "ECs4691"}, {"notes": {"original_bigg_ids": ["ECs4692"]}, "name": "ECs4692", "id": "ECs4692"}, {"notes": {"original_bigg_ids": ["ECs4831"]}, "name": "ECs4831", "id": "ECs4831"}, {"notes": {"original_bigg_ids": ["ECs4829"]}, "name": "ECs4829", "id": "ECs4829"}, {"notes": {"original_bigg_ids": ["ECs3117"]}, "name": "ECs3117", "id": "ECs3117"}, {"notes": {"original_bigg_ids": ["ECs3118"]}, "name": "ECs3118", "id": "ECs3118"}, {"notes": {"original_bigg_ids": ["ECs3538"]}, "name": "ECs3538", "id": "ECs3538"}, {"notes": {"original_bigg_ids": ["ECs3539"]}, "name": "ECs3539", "id": "ECs3539"}, {"notes": {"original_bigg_ids": ["ECs5215"]}, "name": "ECs5215", "id": "ECs5215"}, {"notes": {"original_bigg_ids": ["ECs5214"]}, "name": "ECs5214", "id": "ECs5214"}, {"notes": {"original_bigg_ids": ["ECs4228"]}, "name": "ECs4228", "id": "ECs4228"}, {"notes": {"original_bigg_ids": ["ECs3785"]}, "name": "ECs3785", "id": "ECs3785"}, {"notes": {"original_bigg_ids": ["ECs0676"]}, "name": "ECs0676", "id": "ECs0676"}, {"notes": {"original_bigg_ids": ["ECs2387"]}, "name": "ECs2387", "id": "ECs2387"}, {"notes": {"original_bigg_ids": ["ECs2390"]}, "name": "ECs2390", "id": "ECs2390"}, {"notes": {"original_bigg_ids": ["ECs2386"]}, "name": "ECs2386", "id": "ECs2386"}, {"notes": {"original_bigg_ids": ["ECs2389"]}, "name": "ECs2389", "id": "ECs2389"}, {"notes": {"original_bigg_ids": ["ECs2388"]}, "name": "ECs2388", "id": "ECs2388"}, {"notes": {"original_bigg_ids": ["ECs2391"]}, "name": "ECs2391", "id": "ECs2391"}, {"notes": {"original_bigg_ids": ["ECs0249"]}, "name": "ECs0249", "id": "ECs0249"}, {"notes": {"original_bigg_ids": ["ECs2451"]}, "name": "ECs2451", "id": "ECs2451"}, {"notes": {"original_bigg_ids": ["ECs3605"]}, "name": "ECs3605", "id": "ECs3605"}, {"notes": {"original_bigg_ids": ["ECs3606"]}, "name": "ECs3606", "id": "ECs3606"}, {"notes": {"original_bigg_ids": ["ECs3561"]}, "name": "ECs3561", "id": "ECs3561"}, {"notes": {"original_bigg_ids": ["ECs3560"]}, "name": "ECs3560", "id": "ECs3560"}, {"notes": {"original_bigg_ids": ["srlE"]}, "name": "None", "id": "srlE"}, {"notes": {"original_bigg_ids": ["srlA"]}, "name": "None", "id": "srlA"}, {"notes": {"original_bigg_ids": ["ECs3334"]}, "name": "ECs3334", "id": "ECs3334"}, {"notes": {"original_bigg_ids": ["ECs4468"]}, "name": "ECs4468", "id": "ECs4468"}, {"notes": {"original_bigg_ids": ["ECs2470"]}, "name": "ECs2470", "id": "ECs2470"}, {"notes": {"original_bigg_ids": ["ECs3152"]}, "name": "ECs3152", "id": "ECs3152"}, {"notes": {"original_bigg_ids": ["ECs0625"]}, "name": "ECs0625", "id": "ECs0625"}, {"notes": {"original_bigg_ids": ["ECs4485"]}, "name": "ECs4485", "id": "ECs4485"}, {"notes": {"original_bigg_ids": ["ECs3245"]}, "name": "ECs3245", "id": "ECs3245"}, {"notes": {"original_bigg_ids": ["ECs3657"]}, "name": "ECs3657", "id": "ECs3657"}, {"notes": {"original_bigg_ids": ["ECs2523"]}, "name": "ECs2523", "id": "ECs2523"}, {"notes": {"original_bigg_ids": ["ECs0978"]}, "name": "ECs0978", "id": "ECs0978"}, {"notes": {"original_bigg_ids": ["ECs3996"]}, "name": "ECs3996", "id": "ECs3996"}, {"notes": {"original_bigg_ids": ["ECs3656"]}, "name": "ECs3656", "id": "ECs3656"}, {"notes": {"original_bigg_ids": ["ECs3971"]}, "name": "ECs3971", "id": "ECs3971"}, {"notes": {"original_bigg_ids": ["ECs0410"]}, "name": "ECs0410", "id": "ECs0410"}, {"notes": {"original_bigg_ids": ["ECs3046"]}, "name": "ECs3046", "id": "ECs3046"}, {"notes": {"original_bigg_ids": ["ECs2450"]}, "name": "ECs2450", "id": "ECs2450"}, {"notes": {"original_bigg_ids": ["ECs2452"]}, "name": "ECs2452", "id": "ECs2452"}, {"notes": {"original_bigg_ids": ["ECs3151"]}, "name": "ECs3151", "id": "ECs3151"}, {"notes": {"original_bigg_ids": ["ECs4219"]}, "name": "ECs4219", "id": "ECs4219"}, {"notes": {"original_bigg_ids": ["ECs4147"]}, "name": "ECs4147", "id": "ECs4147"}, {"notes": {"original_bigg_ids": ["ECs4232"]}, "name": "ECs4232", "id": "ECs4232"}, {"notes": {"original_bigg_ids": ["ECs0438"]}, "name": "ECs0438", "id": "ECs0438"}, {"notes": {"original_bigg_ids": ["ECs4868"]}, "name": "ECs4868", "id": "ECs4868"}, {"notes": {"original_bigg_ids": ["ECs2778"]}, "name": "ECs2778", "id": "ECs2778"}, {"notes": {"original_bigg_ids": ["ECs1711"]}, "name": "ECs1711", "id": "ECs1711"}, {"notes": {"original_bigg_ids": ["ECs2290"]}, "name": "ECs2290", "id": "ECs2290"}, {"notes": {"original_bigg_ids": ["ECs2305"]}, "name": "ECs2305", "id": "ECs2305"}, {"notes": {"original_bigg_ids": ["ECs2306"]}, "name": "ECs2306", "id": "ECs2306"}, {"notes": {"original_bigg_ids": ["ECs4834"]}, "name": "ECs4834", "id": "ECs4834"}, {"notes": {"original_bigg_ids": ["ECs2365"]}, "name": "ECs2365", "id": "ECs2365"}, {"notes": {"original_bigg_ids": ["ECs2355"]}, "name": "ECs2355", "id": "ECs2355"}, {"notes": {"original_bigg_ids": ["ECs2132"]}, "name": "ECs2132", "id": "ECs2132"}, {"notes": {"original_bigg_ids": ["ECs3522"]}, "name": "ECs3522", "id": "ECs3522"}, {"notes": {"original_bigg_ids": ["ECs3148"]}, "name": "ECs3148", "id": "ECs3148"}, {"notes": {"original_bigg_ids": ["ECs3149"]}, "name": "ECs3149", "id": "ECs3149"}, {"notes": {"original_bigg_ids": ["ECs0746"]}, "name": "ECs0746", "id": "ECs0746"}, {"notes": {"original_bigg_ids": ["ECs0748"]}, "name": "ECs0748", "id": "ECs0748"}, {"notes": {"original_bigg_ids": ["ECs0749"]}, "name": "ECs0749", "id": "ECs0749"}, {"notes": {"original_bigg_ids": ["ECs0747"]}, "name": "ECs0747", "id": "ECs0747"}, {"notes": {"original_bigg_ids": ["ECs0754"]}, "name": "ECs0754", "id": "ECs0754"}, {"notes": {"original_bigg_ids": ["ECs0753"]}, "name": "ECs0753", "id": "ECs0753"}, {"notes": {"original_bigg_ids": ["ECs2128"]}, "name": "ECs2128", "id": "ECs2128"}, {"notes": {"original_bigg_ids": ["ECs0008"]}, "name": "ECs0008", "id": "ECs0008"}, {"notes": {"original_bigg_ids": ["ECs3326"]}, "name": "ECs3326", "id": "ECs3326"}, {"notes": {"original_bigg_ids": ["ECs3944"]}, "name": "ECs3944", "id": "ECs3944"}, {"notes": {"original_bigg_ids": ["ECs3945"]}, "name": "ECs3945", "id": "ECs3945"}, {"notes": {"original_bigg_ids": ["ECs3946"]}, "name": "ECs3946", "id": "ECs3946"}, {"notes": {"original_bigg_ids": ["ECs0422"]}, "name": "ECs0422", "id": "ECs0422"}, {"notes": {"original_bigg_ids": ["ECs4723"]}, "name": "ECs4723", "id": "ECs4723"}, {"notes": {"original_bigg_ids": ["ECs4724"]}, "name": "ECs4724", "id": "ECs4724"}, {"notes": {"original_bigg_ids": ["ECs4721"]}, "name": "ECs4721", "id": "ECs4721"}, {"notes": {"original_bigg_ids": ["ECs0998"]}, "name": "ECs0998", "id": "ECs0998"}, {"notes": {"original_bigg_ids": ["ECs4017"]}, "name": "ECs4017", "id": "ECs4017"}, {"notes": {"original_bigg_ids": ["ECs2899"]}, "name": "ECs2899", "id": "ECs2899"}, {"notes": {"original_bigg_ids": ["ECs4010"]}, "name": "ECs4010", "id": "ECs4010"}, {"notes": {"original_bigg_ids": ["ECs2898"]}, "name": "ECs2898", "id": "ECs2898"}, {"notes": {"original_bigg_ids": ["ECs0168"]}, "name": "ECs0168", "id": "ECs0168"}, {"notes": {"original_bigg_ids": ["ECs3342"]}, "name": "ECs3342", "id": "ECs3342"}, {"notes": {"original_bigg_ids": ["ECs0071"]}, "name": "ECs0071", "id": "ECs0071"}, {"notes": {"original_bigg_ids": ["ECs0070"]}, "name": "ECs0070", "id": "ECs0070"}, {"notes": {"original_bigg_ids": ["ECs0072"]}, "name": "ECs0072", "id": "ECs0072"}, {"notes": {"original_bigg_ids": ["ECs4494"]}, "name": "ECs4494", "id": "ECs4494"}, {"notes": {"original_bigg_ids": ["ECs3997"]}, "name": "ECs3997", "id": "ECs3997"}, {"notes": {"original_bigg_ids": ["ECs4706"]}, "name": "ECs4706", "id": "ECs4706"}, {"notes": {"original_bigg_ids": ["ECs2426"]}, "name": "ECs2426", "id": "ECs2426"}, {"notes": {"original_bigg_ids": ["ECs4753"]}, "name": "ECs4753", "id": "ECs4753"}, {"notes": {"original_bigg_ids": ["ECs0477"]}, "name": "ECs0477", "id": "ECs0477"}, {"notes": {"original_bigg_ids": ["ECs5575"]}, "name": "None", "id": "ECs5575"}, {"notes": {"original_bigg_ids": ["ECs4913"]}, "name": "ECs4913", "id": "ECs4913"}, {"notes": {"original_bigg_ids": ["ECs4915"]}, "name": "ECs4915", "id": "ECs4915"}, {"notes": {"original_bigg_ids": ["ECs3327"]}, "name": "ECs3327", "id": "ECs3327"}, {"notes": {"original_bigg_ids": ["ECs1152"]}, "name": "ECs1152", "id": "ECs1152"}, {"notes": {"original_bigg_ids": ["ECs1151"]}, "name": "ECs1151", "id": "ECs1151"}, {"notes": {"original_bigg_ids": ["ECs3684"]}, "name": "ECs3684", "id": "ECs3684"}, {"notes": {"original_bigg_ids": ["ECs1484"]}, "name": "ECs1484", "id": "ECs1484"}, {"notes": {"original_bigg_ids": ["ECs0470"]}, "name": "ECs0470", "id": "ECs0470"}, {"notes": {"original_bigg_ids": ["ECs4916"]}, "name": "ECs4916", "id": "ECs4916"}, {"notes": {"original_bigg_ids": ["ECs4844"]}, "name": "ECs4844", "id": "ECs4844"}, {"notes": {"original_bigg_ids": ["ECs0652"]}, "name": "ECs0652", "id": "ECs0652"}, {"notes": {"original_bigg_ids": ["ECs0973"]}, "name": "ECs0973", "id": "ECs0973"}, {"notes": {"original_bigg_ids": ["ECs5216"]}, "name": "ECs5216", "id": "ECs5216"}, {"notes": {"original_bigg_ids": ["ECs2605"]}, "name": "ECs2605", "id": "ECs2605"}, {"notes": {"original_bigg_ids": ["ECs2604"]}, "name": "ECs2604", "id": "ECs2604"}, {"notes": {"original_bigg_ids": ["ECs4399"]}, "name": "ECs4399", "id": "ECs4399"}, {"notes": {"original_bigg_ids": ["treA"]}, "name": "None", "id": "treA"}, {"notes": {"original_bigg_ids": ["ECs5217"]}, "name": "ECs5217", "id": "ECs5217"}, {"notes": {"original_bigg_ids": ["ECs1833"]}, "name": "ECs1833", "id": "ECs1833"}, {"notes": {"original_bigg_ids": ["ECs1832"]}, "name": "ECs1832", "id": "ECs1832"}, {"notes": {"original_bigg_ids": ["ECs4226"]}, "name": "ECs4226", "id": "ECs4226"}, {"notes": {"original_bigg_ids": ["ECs4646"]}, "name": "ECs4646", "id": "ECs4646"}, {"notes": {"original_bigg_ids": ["ECs0570"]}, "name": "ECs0570", "id": "ECs0570"}, {"notes": {"original_bigg_ids": ["ECs4003"]}, "name": "ECs4003", "id": "ECs4003"}, {"notes": {"original_bigg_ids": ["ECs4914"]}, "name": "ECs4914", "id": "ECs4914"}, {"notes": {"original_bigg_ids": ["ECs2346"]}, "name": "ECs2346", "id": "ECs2346"}, {"notes": {"original_bigg_ids": ["ECs2615"]}, "name": "ECs2615", "id": "ECs2615"}, {"notes": {"original_bigg_ids": ["ECs0181"]}, "name": "ECs0181", "id": "ECs0181"}, {"notes": {"original_bigg_ids": ["ECs0089"]}, "name": "ECs0089", "id": "ECs0089"}, {"notes": {"original_bigg_ids": ["ECs4720"]}, "name": "ECs4720", "id": "ECs4720"}, {"notes": {"original_bigg_ids": ["ECs4719"]}, "name": "ECs4719", "id": "ECs4719"}, {"notes": {"original_bigg_ids": ["ECs0183"]}, "name": "ECs0183", "id": "ECs0183"}, {"notes": {"original_bigg_ids": ["ECs4068"]}, "name": "ECs4068", "id": "ECs4068"}, {"notes": {"original_bigg_ids": ["ECs0094"]}, "name": "ECs0094", "id": "ECs0094"}, {"notes": {"original_bigg_ids": ["ECs0092"]}, "name": "ECs0092", "id": "ECs0092"}, {"notes": {"original_bigg_ids": ["ECs0095"]}, "name": "ECs0095", "id": "ECs0095"}, {"notes": {"original_bigg_ids": ["ECs4899"]}, 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"id": "23cump_e"}, {"name": "2,3-diaminopropionate", "notes": {"original_bigg_ids": ["23dappa_e"]}, "charge": 1, "formula": "C3H9N2O2", "compartment": "e", "id": "23dappa_e"}, {"name": "Meso-2,6-Diaminoheptanedioate", "notes": {"original_bigg_ids": ["26dap_DASH_M_e"]}, "charge": 0, "formula": "C7H14N2O4", "compartment": "e", "id": "26dap__M_e"}, {"name": "2-Dehydro-3-deoxy-D-gluconate", "notes": {"original_bigg_ids": ["2ddglcn_e"]}, "charge": -1, "formula": "C6H9O6", "compartment": "e", "id": "2ddglcn_e"}, {"name": "3,4-Dihydroxyphenylacetaldehyde", "notes": {"original_bigg_ids": ["34dhpac_e"]}, "charge": 0, "formula": "C8H8O3", "compartment": "e", "id": "34dhpac_e"}, {"name": "3'-AMP", "notes": {"original_bigg_ids": ["3amp_e"]}, "charge": -2, "formula": "C10H12N5O7P", "compartment": "e", "id": "3amp_e"}, {"name": "3'-cmp", "notes": {"original_bigg_ids": ["3cmp_e"]}, "charge": -2, "formula": "C9H12N3O8P", "compartment": "e", "id": "3cmp_e"}, {"name": "3'-GMP", "notes": 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"compartment": "e", "id": "anhgm_e"}, {"name": "L-Arabinose", "notes": {"original_bigg_ids": ["arab_DASH_L_e"]}, "charge": 0, "formula": "C5H10O5", "compartment": "e", "id": "arab__L_e"}, {"name": "Arbutin", "notes": {"original_bigg_ids": ["arbt_e"]}, "charge": 0, "formula": "C12H16O7", "compartment": "e", "id": "arbt_e"}, {"name": "Aerobactin minus Fe3", "notes": {"original_bigg_ids": ["arbtn_e"]}, "charge": -3, "formula": "C22H33N4O13", "compartment": "e", "id": "arbtn_e"}, {"name": "Aerobactin", "notes": {"original_bigg_ids": ["arbtn_DASH_fe3_e"]}, "charge": 0, "formula": "C22H33FeN4O13", "compartment": "e", "id": "arbtn_fe3_e"}, {"name": "L-Arginine", "notes": {"original_bigg_ids": ["arg_DASH_L_e"]}, "charge": 1, "formula": "C6H15N4O2", "compartment": "e", "id": "arg__L_e"}, {"name": "L-Ascorbate", "notes": {"original_bigg_ids": ["ascb_DASH_L_e"]}, "charge": 0, "formula": "C6H8O6", "compartment": "e", "id": "ascb__L_e"}, {"name": "L-Asparagine", "notes": {"original_bigg_ids": 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"id": "malt_e"}, {"name": "Maltohexaose", "notes": {"original_bigg_ids": ["malthx_e"]}, "charge": 0, "formula": "C36H62O31", "compartment": "e", "id": "malthx_e"}, {"name": "Maltopentaose", "notes": {"original_bigg_ids": ["maltpt_e"]}, "charge": 0, "formula": "C30H52O26", "compartment": "e", "id": "maltpt_e"}, {"name": "Maltotriose", "notes": {"original_bigg_ids": ["malttr_e"]}, "charge": 0, "formula": "C18H32O16", "compartment": "e", "id": "malttr_e"}, {"name": "Maltotetraose", "notes": {"original_bigg_ids": ["maltttr_e"]}, "charge": 0, "formula": "C24H42O21", "compartment": "e", "id": "maltttr_e"}, {"name": "D-Mannose", "notes": {"original_bigg_ids": ["man_e"]}, "charge": 0, "formula": "C6H12O6", "compartment": "e", "id": "man_e"}, {"name": "D-Mannose 6-phosphate", "notes": {"original_bigg_ids": ["man6p_e"]}, "charge": -2, "formula": "C6H11O9P", "compartment": "e", "id": "man6p_e"}, {"name": "2(alpha-D-Mannosyl)-D-glycerate", "notes": {"original_bigg_ids": ["manglyc_e"]}, "charge": 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{"name": "Magnesium", "notes": {"original_bigg_ids": ["mg2_e"]}, "charge": 2, "formula": "Mg", "compartment": "e", "id": "mg2_e"}, {"name": "Minocycline", "notes": {"original_bigg_ids": ["mincyc_e"]}, "charge": 0, "formula": "C23H27N3O7", "compartment": "e", "id": "mincyc_e"}, {"name": "Myo-Inositol hexakisphosphate", "notes": {"original_bigg_ids": ["minohp_e"]}, "charge": -12, "formula": "C6H6O24P6", "compartment": "e", "id": "minohp_e"}, {"name": "S-Methyl-L-methionine", "notes": {"original_bigg_ids": ["mmet_e"]}, "charge": 1, "formula": "C6H14NO2S", "compartment": "e", "id": "mmet_e"}, {"name": "Mn2+", "notes": {"original_bigg_ids": ["mn2_e"]}, "charge": 2, "formula": "Mn", "compartment": "e", "id": "mn2_e"}, {"name": "D-Mannitol", "notes": {"original_bigg_ids": ["mnl_e"]}, "charge": 0, "formula": "C6H14O6", "compartment": "e", "id": "mnl_e"}, {"name": "Molybdate", "notes": {"original_bigg_ids": ["mobd_e"]}, "charge": -2, "formula": "MoO4", "compartment": "e", "id": "mobd_e"}, {"name": "Methanesulfonate", "notes": {"original_bigg_ids": ["mso3_e"]}, "charge": -1, "formula": "CH3O3S", "compartment": "e", "id": "mso3_e"}, {"name": "Nitrous oxide", "notes": {"original_bigg_ids": ["n2o_e"]}, "charge": 0, "formula": "N2O", "compartment": "e", "id": "n2o_e"}, {"name": "Sodium", "notes": {"original_bigg_ids": ["na1_e"]}, "charge": 1, "formula": "Na", "compartment": "e", "id": "na1_e"}, {"name": "Nicotinate", "notes": {"original_bigg_ids": ["nac_e"]}, "charge": -1, "formula": "C6H4NO2", "compartment": "e", "id": "nac_e"}, {"name": "Ammonium", "notes": {"original_bigg_ids": ["nh4_e"]}, "charge": 1, "formula": "H4N", "compartment": "e", "id": "nh4_e"}, {"name": "Nickel", "notes": {"original_bigg_ids": ["ni2_e"]}, "charge": 2, "formula": "Ni", "compartment": "e", "id": "ni2_e"}, {"name": "NMN", "notes": {"original_bigg_ids": ["nmn_e"]}, "charge": -1, "formula": "C11H14N2O8P", "compartment": "e", "id": "nmn_e"}, {"name": "Nitric oxide", "notes": {"original_bigg_ids": 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"id": "slnt_e"}, {"name": "Sulfur dioxide", "notes": {"original_bigg_ids": ["so2_e"]}, "charge": 0, "formula": "O2S", "compartment": "e", "id": "so2_e"}, {"name": "Sulfite", "notes": {"original_bigg_ids": ["so3_e"]}, "charge": -2, "formula": "O3S", "compartment": "e", "id": "so3_e"}, {"name": "Sulfate", "notes": {"original_bigg_ids": ["so4_e"]}, "charge": -2, "formula": "O4S", "compartment": "e", "id": "so4_e"}, {"name": "Spermidine", "notes": {"original_bigg_ids": ["spmd_e"]}, "charge": 3, "formula": "C7H22N3", "compartment": "e", "id": "spmd_e"}, {"name": "Succinate", "notes": {"original_bigg_ids": ["succ_e"]}, "charge": -2, "formula": "C4H4O4", "compartment": "e", "id": "succ_e"}, {"name": "Sucrose", "notes": {"original_bigg_ids": ["sucr_e"]}, "charge": 0, "formula": "C12H22O11", "compartment": "e", "id": "sucr_e"}, {"name": "Sulfoacetate", "notes": {"original_bigg_ids": ["sulfac_e"]}, "charge": -2, "formula": "C2H2O5S", "compartment": "e", "id": "sulfac_e"}, {"name": "D-tartrate", 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"C20H38O9P1", "compartment": "p", "id": "2agpg141_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C14:1)", "notes": {"original_bigg_ids": ["2agpg141_c"]}, "charge": -1, "formula": "C20H38O9P1", "compartment": "c", "id": "2agpg141_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:0)", "notes": {"original_bigg_ids": ["2agpg160_c"]}, "charge": -1, "formula": "C22H44O9P1", "compartment": "c", "id": "2agpg160_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:0)", "notes": {"original_bigg_ids": ["2agpg160_p"]}, "charge": -1, "formula": "C22H44O9P1", "compartment": "p", "id": "2agpg160_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:1)", "notes": {"original_bigg_ids": ["2agpg161_p"]}, "charge": -1, "formula": "C22H42O9P1", "compartment": "p", "id": "2agpg161_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:1)", "notes": {"original_bigg_ids": ["2agpg161_c"]}, "charge": -1, "formula": "C22H42O9P1", "compartment": "c", "id": "2agpg161_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:0)", "notes": {"original_bigg_ids": ["2agpg180_c"]}, "charge": -1, "formula": "C24H48O9P1", "compartment": "c", "id": "2agpg180_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:0)", "notes": {"original_bigg_ids": ["2agpg180_p"]}, "charge": -1, "formula": "C24H48O9P1", "compartment": "p", "id": "2agpg180_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:1)", "notes": {"original_bigg_ids": ["2agpg181_c"]}, "charge": -1, "formula": "C24H46O9P1", "compartment": "c", "id": "2agpg181_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:1)", "notes": {"original_bigg_ids": ["2agpg181_p"]}, "charge": -1, "formula": "C24H46O9P1", "compartment": "p", "id": "2agpg181_p"}, {"name": "Phosphatidylglycerol (didodecanoyl, n-C12:0)", "notes": {"original_bigg_ids": ["pg120_c"]}, "charge": -1, "formula": "C30H58O10P1", "compartment": "c", "id": "pg120_c"}, {"name": "Phosphatidylglycerol (ditetradecanoyl, n-C14:0)", "notes": {"original_bigg_ids": ["pg140_c"]}, "charge": -1, "formula": "C34H66O10P1", "compartment": "c", "id": "pg140_c"}, {"name": "Phosphatidylglycerol (ditetradec-7-enoyl, n-C14:1)", "notes": {"original_bigg_ids": ["pg141_c"]}, "charge": -1, "formula": "C34H62O10P1", "compartment": "c", "id": "pg141_c"}, {"name": "Phosphatidylglycerol (dioctadecanoyl, n-C18:0)", "notes": {"original_bigg_ids": ["pg180_c"]}, "charge": -1, "formula": "C42H82O10P1", "compartment": "c", "id": "pg180_c"}, {"name": "2-Dehydro-L-gulonate", "notes": {"original_bigg_ids": ["2dhguln_c"]}, "charge": -1, "formula": "C6H9O7", "compartment": "c", "id": "2dhguln_c"}, {"name": "D-Gluconate", "notes": {"original_bigg_ids": ["glcn_c"]}, "charge": -1, "formula": "C6H11O7", "compartment": "c", "id": "glcn_c"}, {"name": "L-Idonate", "notes": {"original_bigg_ids": ["idon_DASH_L_c"]}, "charge": -1, "formula": "C6H11O7", "compartment": "c", "id": "idon__L_c"}, {"name": "2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate", "notes": {"original_bigg_ids": ["2mahmp_c"]}, "charge": -3, "formula": "C6H8N3O7P2", "compartment": "c", "id": "2mahmp_c"}, {"name": "4-Amino-2-methyl-5-phosphomethylpyrimidine", "notes": {"original_bigg_ids": ["4ampm_c"]}, "charge": -2, "formula": "C6H8N3O4P", "compartment": "c", "id": "4ampm_c"}, {"name": "3,4-Dihydroxyphenylacetaldehyde", "notes": {"original_bigg_ids": ["34dhpac_p"]}, "charge": 0, "formula": "C8H8O3", "compartment": "p", "id": "34dhpac_p"}, {"name": "3-Aminoacrylate", "notes": {"original_bigg_ids": ["3amac_c"]}, "charge": -1, "formula": "C3H4NO2", "compartment": "c", "id": "3amac_c"}, {"name": "Malonate semialdehyde", "notes": {"original_bigg_ids": ["msa_c"]}, "charge": -1, "formula": "C3H3O3", "compartment": "c", "id": "msa_c"}, {"name": "(R)-3-Hydroxydecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hdecACP_c"]}, "charge": -1, "formula": "C21H39N2O9PRS", "compartment": "c", "id": "3hdecACP_c"}, {"name": "Trans-Dec-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["tdec2eACP_c"]}, "charge": -1, "formula": "C21H37N2O8PRS", "compartment": "c", "id": "tdec2eACP_c"}, {"name": "(R)-3-Hydroxydodecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hddecACP_c"]}, "charge": -1, "formula": "C23H43N2O9PRS", "compartment": "c", "id": "3hddecACP_c"}, {"name": "Trans-Dodec-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["tddec2eACP_c"]}, "charge": -1, "formula": "C23H41N2O8PRS", "compartment": "c", "id": "tddec2eACP_c"}, {"name": "Trans-3-cis-5-dodecenoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["t3c5ddeceACP_c"]}, "charge": -1, "formula": "C23H39N2O8PRS", "compartment": "c", "id": "t3c5ddeceACP_c"}, {"name": "(R)-3-hydroxy-cis-dodec-5-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hcddec5eACP_c"]}, "charge": -1, "formula": "C23H41N2O9PRS", "compartment": "c", "id": "3hcddec5eACP_c"}, {"name": "Trans-Tetradec-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["tmrs2eACP_c"]}, "charge": -1, "formula": "C25H45N2O8PRS", "compartment": "c", "id": "tmrs2eACP_c"}, {"name": "(R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hmrsACP_c"]}, "charge": -1, "formula": "C25H47N2O9PRS", "compartment": "c", "id": "3hmrsACP_c"}, {"name": "(R)-3-hydroxy-cis-myristol-7-eoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hcmrs7eACP_c"]}, "charge": -1, "formula": "C25H45N2O9PRS", "compartment": "c", "id": "3hcmrs7eACP_c"}, {"name": "Trans-3-cis-7-myristoleoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["t3c7mrseACP_c"]}, "charge": -1, "formula": "C25H43N2O8PRS", "compartment": "c", "id": "t3c7mrseACP_c"}, {"name": "R-3-hydroxypalmitoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hpalmACP_c"]}, "charge": -1, "formula": "C27H51N2O9PRS", "compartment": "c", "id": "3hpalmACP_c"}, {"name": "Trans-Hexadec-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["tpalm2eACP_c"]}, "charge": -1, "formula": "C27H49N2O8PRS", "compartment": "c", "id": "tpalm2eACP_c"}, {"name": "(R)-3-hydroxy-cis-palm-9-eoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hcpalm9eACP_c"]}, "charge": -1, "formula": "C27H49N2O9PRS", "compartment": "c", "id": "3hcpalm9eACP_c"}, {"name": "Trans-3-cis-9-palmitoleoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["t3c9palmeACP_c"]}, "charge": -1, "formula": "C27H47N2O8PRS", "compartment": "c", "id": "t3c9palmeACP_c"}, {"name": "(R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hoctaACP_c"]}, "charge": -1, "formula": "C29H55N2O9PRS", "compartment": "c", "id": "3hoctaACP_c"}, {"name": "Trans-octadec-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["toctd2eACP_c"]}, "charge": -1, "formula": "C29H53N2O8PRS", "compartment": "c", "id": "toctd2eACP_c"}, {"name": "(R)-3-hydroxy-cis-vacc-11-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hcvac11eACP_c"]}, "charge": -1, "formula": "C29H53N2O9PRS", "compartment": "c", "id": "3hcvac11eACP_c"}, {"name": "Trans-3-cis-11-vacceoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["t3c11vaceACP_c"]}, "charge": -1, "formula": "C29H51N2O8PRS", "compartment": "c", "id": "t3c11vaceACP_c"}, {"name": "But-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["but2eACP_c"]}, "charge": -1, "formula": "C15H25N2O8PRS", "compartment": "c", "id": "but2eACP_c"}, {"name": "(3R)-3-Hydroxyacyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3haACP_c"]}, "charge": -1, "formula": "C15H27N2O9PRS", "compartment": "c", "id": "3haACP_c"}, {"name": "(R)-3-Hydroxyhexanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hhexACP_c"]}, "charge": -1, "formula": "C17H31N2O9PRS", "compartment": "c", "id": "3hhexACP_c"}, {"name": "Trans-Hex-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["thex2eACP_c"]}, "charge": -1, "formula": "C17H29N2O8PRS", "compartment": "c", "id": "thex2eACP_c"}, {"name": "(R)-3-Hydroxyoctanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hoctACP_c"]}, "charge": -1, "formula": "C19H35N2O9PRS", "compartment": "c", "id": "3hoctACP_c"}, {"name": "Trans-Oct-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["toct2eACP_c"]}, "charge": -1, "formula": "C19H33N2O8PRS", "compartment": "c", "id": "toct2eACP_c"}, {"name": "3-hydroxycinnamic acid", "notes": {"original_bigg_ids": ["3hcinnm_c"]}, "charge": -1, "formula": "C9H7O3", "compartment": "c", "id": "3hcinnm_c"}, {"name": "2,3-dihydroxicinnamic acid", "notes": {"original_bigg_ids": ["dhcinnm_c"]}, "charge": -1, "formula": "C9H7O4", "compartment": "c", "id": "dhcinnm_c"}, {"name": "O2", "notes": {"original_bigg_ids": ["o2_c"]}, "charge": 0, "formula": "O2", "compartment": "c", "id": "o2_c"}, {"name": "3-(2,3-Dihydroxyphenyl)propanoate", "notes": {"original_bigg_ids": ["dhpppn_c"]}, "charge": -1, "formula": "C9H9O4", "compartment": "c", "id": "dhpppn_c"}, {"name": "3-(3-hydroxy-phenyl)propionate", "notes": {"original_bigg_ids": ["3hpppn_c"]}, "charge": -1, "formula": "C9H9O3", "compartment": "c", "id": "3hpppn_c"}, {"name": "3-Hydroxypropanoate", "notes": {"original_bigg_ids": ["3hpp_p"]}, "charge": -1, "formula": "C3H5O3", "compartment": "p", "id": "3hpp_p"}, {"name": "3-Hydroxypropanoate", "notes": {"original_bigg_ids": ["3hpp_c"]}, "charge": -1, "formula": "C3H5O3", "compartment": "c", "id": "3hpp_c"}, {"name": "Phosphate", "notes": {"original_bigg_ids": ["pi_p"]}, "charge": -2, "formula": "HO4P", "compartment": "p", "id": "pi_p"}, {"name": "Uridine", "notes": {"original_bigg_ids": ["uri_p"]}, "charge": 0, "formula": "C9H12N2O6", "compartment": "p", "id": "uri_p"}, {"name": "Cytidine", "notes": {"original_bigg_ids": ["cytd_p"]}, "charge": 0, "formula": "C9H13N3O5", "compartment": "p", "id": "cytd_p"}, {"name": "Adenosine", "notes": {"original_bigg_ids": ["adn_p"]}, "charge": 0, "formula": "C10H13N5O4", "compartment": "p", "id": "adn_p"}, {"name": "Guanosine", "notes": {"original_bigg_ids": ["gsn_p"]}, "charge": 0, "formula": "C10H13N5O5", "compartment": "p", "id": "gsn_p"}, {"name": "3-Oxodecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3odecACP_c"]}, "charge": -1, "formula": "C21H37N2O9PRS", "compartment": "c", "id": "3odecACP_c"}, {"name": "3-Oxododecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3oddecACP_c"]}, "charge": -1, "formula": "C23H41N2O9PRS", "compartment": "c", "id": "3oddecACP_c"}, {"name": "3-oxo-cis-dodec-5-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ocddec5eACP_c"]}, "charge": -1, "formula": "C23H39N2O9PRS", "compartment": "c", "id": "3ocddec5eACP_c"}, {"name": "3-Oxotetradecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3omrsACP_c"]}, "charge": -1, "formula": "C25H45N2O9PRS", "compartment": "c", "id": "3omrsACP_c"}, {"name": "3-oxo-cis-myristol-7-eoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ocmrs7eACP_c"]}, "charge": -1, "formula": "C25H43N2O9PRS", "compartment": "c", "id": "3ocmrs7eACP_c"}, {"name": "3-Oxohexadecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3opalmACP_c"]}, "charge": -1, "formula": "C27H49N2O9PRS", "compartment": "c", "id": "3opalmACP_c"}, {"name": "3-oxo-cis-palm-9-eoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ocpalm9eACP_c"]}, "charge": -1, "formula": "C27H47N2O9PRS", "compartment": "c", "id": "3ocpalm9eACP_c"}, {"name": "3-Oxooctadecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ooctdACP_c"]}, "charge": -1, "formula": "C29H53N2O9PRS", "compartment": "c", "id": "3ooctdACP_c"}, {"name": "3-oxo-cis-vacc-11-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ocvac11eACP_c"]}, "charge": -1, "formula": "C29H51N2O9PRS", "compartment": "c", "id": "3ocvac11eACP_c"}, {"name": "Acetoacetyl-ACP", "notes": {"original_bigg_ids": ["actACP_c"]}, "charge": -1, "formula": "C15H25N2O9PRS", "compartment": "c", "id": "actACP_c"}, {"name": "3-Oxohexanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ohexACP_c"]}, "charge": -1, "formula": "C17H29N2O9PRS", "compartment": "c", "id": "3ohexACP_c"}, {"name": "3-Oxooctanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ooctACP_c"]}, "charge": -1, "formula": "C19H33N2O9PRS", "compartment": "c", "id": "3ooctACP_c"}, {"name": "CO2", "notes": {"original_bigg_ids": ["co2_c"]}, "charge": 0, "formula": "CO2", "compartment": "c", "id": "co2_c"}, {"name": "Acyl carrier protein", "notes": {"original_bigg_ids": ["ACP_c"]}, "charge": -1, "formula": "C11H21N2O7PRS", "compartment": "c", "id": "ACP_c"}, {"name": "Octanoyl-ACP (n-C8:0ACP)", "notes": {"original_bigg_ids": ["ocACP_c"]}, "charge": -1, "formula": "C19H35N2O8PRS", "compartment": "c", "id": "ocACP_c"}, {"name": "Malonyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["malACP_c"]}, "charge": -2, "formula": "C14H22N2O10PRS", "compartment": "c", "id": "malACP_c"}, {"name": "Decanoyl-ACP (n-C10:0ACP)", "notes": {"original_bigg_ids": ["dcaACP_c"]}, "charge": -1, "formula": "C21H39N2O8PRS", "compartment": "c", "id": "dcaACP_c"}, {"name": "Cis-dec-3-enoyl-[acyl-carrier protein] (n-C10:1)", "notes": {"original_bigg_ids": ["cdec3eACP_c"]}, "charge": -1, "formula": "C21H37N2O8PRS", "compartment": "c", "id": "cdec3eACP_c"}, {"name": "Dodecanoyl-ACP (n-C12:0ACP)", "notes": {"original_bigg_ids": ["ddcaACP_c"]}, "charge": -1, "formula": "C23H43N2O8PRS", "compartment": "c", "id": "ddcaACP_c"}, {"name": "Cis-dodec-5-enoyl-[acyl-carrier protein] (n-C12:1)", "notes": {"original_bigg_ids": ["cddec5eACP_c"]}, "charge": -1, "formula": "C23H41N2O8PRS", "compartment": "c", "id": "cddec5eACP_c"}, {"name": "Myristoyl-ACP (n-C14:0ACP)", "notes": {"original_bigg_ids": ["myrsACP_c"]}, "charge": -1, "formula": "C25H47N2O8PRS", "compartment": "c", "id": "myrsACP_c"}, {"name": "Cis-tetradec-7-enoyl-[acyl-carrier protein] (n-C14:1)", "notes": {"original_bigg_ids": ["tdeACP_c"]}, "charge": -1, "formula": "C25H45N2O8PRS", "compartment": "c", "id": "tdeACP_c"}, {"name": "Palmitoyl-ACP (n-C16:0ACP)", "notes": {"original_bigg_ids": ["palmACP_c"]}, "charge": -1, "formula": "C27H51N2O8PRS", "compartment": "c", "id": "palmACP_c"}, {"name": "Cis-hexadec-9-enoyl-[acyl-carrier protein] (n-C16:1)", "notes": {"original_bigg_ids": ["hdeACP_c"]}, "charge": -1, "formula": "C27H49N2O8PRS", "compartment": "c", "id": "hdeACP_c"}, {"name": "Butyryl-ACP (n-C4:0ACP)", "notes": {"original_bigg_ids": ["butACP_c"]}, "charge": -1, "formula": "C15H27N2O8PRS", "compartment": "c", "id": "butACP_c"}, {"name": "Hexanoyl-ACP (n-C6:0ACP)", "notes": {"original_bigg_ids": ["hexACP_c"]}, "charge": -1, "formula": "C17H31N2O8PRS", "compartment": "c", "id": "hexACP_c"}, {"name": "L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate", "notes": {"original_bigg_ids": ["LalaDgluMdap_p"]}, "charge": -1, "formula": "C15H25N4O8", "compartment": "p", "id": "LalaDgluMdap_p"}, {"name": "L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate", "notes": {"original_bigg_ids": ["LalaDgluMdap_c"]}, "charge": -1, "formula": "C15H25N4O8", "compartment": "c", "id": "LalaDgluMdap_c"}, {"name": "4-Hydroxyphenylacetaldehyde", "notes": {"original_bigg_ids": ["4hoxpacd_p"]}, "charge": 0, "formula": "C8H8O2", "compartment": "p", "id": "4hoxpacd_p"}, {"name": "O-Phospho-4-hydroxy-L-threonine", "notes": {"original_bigg_ids": ["phthr_c"]}, "charge": -2, "formula": "C4H8NO7P", "compartment": "c", "id": "phthr_c"}, {"name": "4-Hydroxy-L-threonine", "notes": {"original_bigg_ids": ["4hthr_c"]}, "charge": 0, "formula": "C4H9NO4", "compartment": "c", "id": "4hthr_c"}, {"name": "L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine", "notes": {"original_bigg_ids": ["LalaDgluMdapDala_c"]}, "charge": -1, "formula": "C18H30N5O9", "compartment": "c", "id": "LalaDgluMdapDala_c"}, {"name": "D-Alanine", "notes": {"original_bigg_ids": ["ala_DASH_D_c"]}, "charge": 0, 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0, "formula": "C23H48NO7P1", "compartment": "p", "id": "1agpe180_p"}, {"name": "1-Acyl-sn-glycero-3-phosphoethanolamine (n-C18:1)", "notes": {"original_bigg_ids": ["1agpe181_p"]}, "charge": 0, "formula": "C23H46NO7P1", "compartment": "p", "id": "1agpe181_p"}, {"name": "1-Acyl-sn-glycero-3-phosphoglycerol (n-C12:0)", "notes": {"original_bigg_ids": ["1agpg120_p"]}, "charge": -1, "formula": "C18H36O9P1", "compartment": "p", "id": "1agpg120_p"}, {"name": "1-Acyl-sn-glycero-3-phosphoglycerol (n-C14:0)", "notes": {"original_bigg_ids": ["1agpg140_p"]}, "charge": -1, "formula": "C20H40O9P1", "compartment": "p", "id": "1agpg140_p"}, {"name": "1-Acyl-sn-glycero-3-phosphoglycerol (n-C14:1)", "notes": {"original_bigg_ids": ["1agpg141_p"]}, "charge": -1, "formula": "C20H38O9P1", "compartment": "p", "id": "1agpg141_p"}, {"name": "1-Acyl-sn-glycero-3-phosphoglycerol (n-C16:0)", "notes": {"original_bigg_ids": ["1agpg160_p"]}, "charge": -1, "formula": "C22H44O9P1", "compartment": "p", "id": "1agpg160_p"}, {"name": "1-Acyl-sn-glycero-3-phosphoglycerol (n-C16:1)", "notes": {"original_bigg_ids": ["1agpg161_p"]}, "charge": -1, "formula": "C22H42O9P1", "compartment": "p", "id": "1agpg161_p"}, {"name": "1-Acyl-sn-glycero-3-phosphoglycerol (n-C18:0)", "notes": {"original_bigg_ids": ["1agpg180_p"]}, "charge": -1, "formula": "C24H48O9P1", "compartment": "p", "id": "1agpg180_p"}, {"name": "1-Acyl-sn-glycero-3-phosphoglycerol (n-C18:1)", "notes": {"original_bigg_ids": ["1agpg181_p"]}, "charge": -1, "formula": "C24H46O9P1", "compartment": "p", "id": "1agpg181_p"}, {"name": "Acyl phosphatidylglycerol (n-C12:0)", "notes": {"original_bigg_ids": ["apg120_c"]}, "charge": -1, "formula": "C42H80O11P", "compartment": "c", "id": "apg120_c"}, {"name": "Acyl phosphatidylglycerol (n-C14:0)", "notes": {"original_bigg_ids": ["apg140_c"]}, "charge": -1, "formula": "C48H92O11P", "compartment": "c", "id": "apg140_c"}, {"name": "Acyl phosphatidylglycerol (n-C14:1)", "notes": {"original_bigg_ids": ["apg141_c"]}, "charge": -1, "formula": "C48H86O11P", "compartment": "c", "id": "apg141_c"}, {"name": "Acyl phosphatidylglycerol (n-C16:0)", "notes": {"original_bigg_ids": ["apg160_c"]}, "charge": -1, "formula": "C54H104O11P", "compartment": "c", "id": "apg160_c"}, {"name": "Acyl phosphatidylglycerol (n-C16:1)", "notes": {"original_bigg_ids": ["apg161_c"]}, "charge": -1, "formula": "C54H98O11P", "compartment": "c", "id": "apg161_c"}, {"name": "Acyl phosphatidylglycerol (n-C18:0)", "notes": {"original_bigg_ids": ["apg180_c"]}, "charge": -1, "formula": "C60H116O11P", "compartment": "c", "id": "apg180_c"}, {"name": "Acyl phosphatidylglycerol (n-C18:1)", "notes": {"original_bigg_ids": ["apg181_c"]}, "charge": -1, "formula": "C60H110O11P", "compartment": "c", "id": "apg181_c"}, {"name": "L-Lysine-tRNA (Lys)", "notes": {"original_bigg_ids": ["lystrna_c"]}, "charge": 2, "formula": "C6H14N2OR", "compartment": "c", "id": "lystrna_c"}, {"name": "TRNA(Lys)", "notes": {"original_bigg_ids": ["trnalys_c"]}, "charge": 0, "formula": "R", "compartment": "c", "id": "trnalys_c"}, {"name": "L-Lyxose", "notes": {"original_bigg_ids": ["lyx_DASH_L_c"]}, "charge": 0, "formula": "C5H10O5", "compartment": "c", "id": "lyx__L_c"}, {"name": "L-Xylulose", "notes": {"original_bigg_ids": ["xylu_DASH_L_c"]}, "charge": 0, "formula": "C5H10O5", "compartment": "c", "id": "xylu__L_c"}, {"name": "L-Lyxose", "notes": {"original_bigg_ids": ["lyx_DASH_L_p"]}, "charge": 0, "formula": "C5H10O5", "compartment": "p", "id": "lyx__L_p"}, {"name": "D-Mannitol 1-phosphate", "notes": {"original_bigg_ids": ["mnl1p_c"]}, "charge": -2, "formula": "C6H13O9P", "compartment": "c", "id": "mnl1p_c"}, {"name": "Malonyl-CoA methyl ester", "notes": {"original_bigg_ids": ["malcoame_c"]}, "charge": -4, "formula": "C25H36N7O19P3S", "compartment": "c", "id": "malcoame_c"}, {"name": "D-Malate", "notes": {"original_bigg_ids": ["mal_DASH_D_c"]}, "charge": -2, "formula": "C4H4O5", "compartment": "c", "id": "mal__D_c"}, {"name": "D-Malate", "notes": {"original_bigg_ids": ["mal_DASH_D_p"]}, "charge": -2, "formula": "C4H4O5", "compartment": "p", "id": "mal__D_p"}, {"name": "Acetyl-maltose", "notes": {"original_bigg_ids": ["acmalt_c"]}, "charge": 0, "formula": "C14H24O12", "compartment": "c", "id": "acmalt_c"}, {"name": "Maltopentaose", "notes": {"original_bigg_ids": ["maltpt_p"]}, "charge": 0, "formula": "C30H52O26", "compartment": "p", "id": "maltpt_p"}, {"name": "Maltotriose", "notes": {"original_bigg_ids": ["malttr_p"]}, "charge": 0, "formula": "C18H32O16", "compartment": "p", "id": "malttr_p"}, {"name": "Maltotetraose", "notes": {"original_bigg_ids": ["maltttr_p"]}, "charge": 0, "formula": "C24H42O21", "compartment": "p", "id": "maltttr_p"}, {"name": "Maltose", "notes": {"original_bigg_ids": ["malt_p"]}, "charge": 0, "formula": "C12H22O11", "compartment": "p", "id": "malt_p"}, {"name": "Maltose 6'-phosphate", "notes": {"original_bigg_ids": ["malt6p_c"]}, "charge": -2, "formula": "C12H21O14P", "compartment": "c", "id": "malt6p_c"}, {"name": "L-Malate", "notes": {"original_bigg_ids": ["mal_DASH_L_p"]}, "charge": -2, "formula": "C4H4O5", "compartment": "p", "id": "mal__L_p"}, {"name": "D-Mannose 6-phosphate", "notes": {"original_bigg_ids": ["man6p_p"]}, "charge": -2, "formula": "C6H11O9P", "compartment": "p", "id": "man6p_p"}, {"name": "D-Mannonate", "notes": {"original_bigg_ids": ["mana_c"]}, "charge": -1, "formula": "C6H11O7", "compartment": "c", "id": "mana_c"}, {"name": "2(alpha-D-Mannosyl)-D-glycerate", "notes": {"original_bigg_ids": ["manglyc_p"]}, "charge": -1, "formula": "C9H15O9", "compartment": "p", "id": "manglyc_p"}, {"name": "D-Mannose", "notes": {"original_bigg_ids": ["man_p"]}, "charge": 0, "formula": "C6H12O6", "compartment": "p", "id": "man_p"}, {"name": "2-Methylcitrate", "notes": {"original_bigg_ids": ["2mcit_c"]}, "charge": -3, "formula": "C7H7O7", "compartment": "c", "id": "2mcit_c"}, {"name": "Cis-2-Methylaconitate", "notes": {"original_bigg_ids": 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["uaagmda_c"]}, "charge": -4, "formula": "C95H152N8O28P2", "compartment": "c", "id": "uaagmda_c"}, {"name": "MoaD Protein with carboxylate", "notes": {"original_bigg_ids": ["moadcoo_c"]}, "charge": -1, "formula": "C1O2X", "compartment": "c", "id": "moadcoo_c"}, {"name": "Methanesulfonate", "notes": {"original_bigg_ids": ["mso3_p"]}, "charge": -1, "formula": "CH3O3S", "compartment": "p", "id": "mso3_p"}, {"name": "N-Methyltryptophan", "notes": {"original_bigg_ids": ["Nmtrp_c"]}, "charge": 0, "formula": "C12H14N2O2", "compartment": "c", "id": "Nmtrp_c"}, {"name": "Nitrous oxide", "notes": {"original_bigg_ids": ["n2o_p"]}, "charge": 0, "formula": "N2O", "compartment": "p", "id": "n2o_p"}, {"name": "Nicotinate", "notes": {"original_bigg_ids": ["nac_p"]}, "charge": -1, "formula": "C6H4NO2", "compartment": "p", "id": "nac_p"}, {"name": "Nicotinate", "notes": {"original_bigg_ids": ["nac_c"]}, "charge": -1, "formula": "C6H4NO2", "compartment": "c", "id": "nac_c"}, {"name": "NMN", "notes": {"original_bigg_ids": ["nmn_c"]}, "charge": -1, "formula": "C11H14N2O8P", "compartment": "c", "id": "nmn_c"}, {"name": "Nicotinamide", "notes": {"original_bigg_ids": ["ncam_c"]}, "charge": 0, "formula": "C6H6N2O", "compartment": "c", "id": "ncam_c"}, {"name": "Deamino-NAD+", "notes": {"original_bigg_ids": ["dnad_c"]}, "charge": -2, "formula": "C21H24N6O15P2", "compartment": "c", "id": "dnad_c"}, {"name": "Nicotinate D-ribonucleotide", "notes": {"original_bigg_ids": ["nicrnt_c"]}, "charge": -2, "formula": "C11H12NO9P", "compartment": "c", "id": "nicrnt_c"}, {"name": "DUDP", "notes": {"original_bigg_ids": ["dudp_c"]}, "charge": -3, "formula": "C9H11N2O11P2", "compartment": "c", "id": "dudp_c"}, {"name": "Nickel", "notes": {"original_bigg_ids": ["ni2_p"]}, "charge": 2, "formula": "Ni", "compartment": "p", "id": "ni2_p"}, {"name": "NMN", "notes": {"original_bigg_ids": ["nmn_p"]}, "charge": -1, "formula": "C11H14N2O8P", "compartment": "p", "id": "nmn_p"}, {"name": "N1-(5-Phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole", "notes": {"original_bigg_ids": ["5prdmbz_c"]}, "charge": -2, "formula": "C14H17N2O7P", "compartment": "c", "id": "5prdmbz_c"}, {"name": "5,6-Dimethylbenzimidazole", "notes": {"original_bigg_ids": ["dmbzid_c"]}, "charge": 0, "formula": "C9H10N2", "compartment": "c", "id": "dmbzid_c"}, {"name": "Quinolinate", "notes": {"original_bigg_ids": ["quln_c"]}, "charge": -2, "formula": "C7H3NO4", "compartment": "c", "id": "quln_c"}, {"name": "Nitrite", "notes": {"original_bigg_ids": ["no2_p"]}, "charge": -1, "formula": "NO2", "compartment": "p", "id": "no2_p"}, {"name": "Nitrite", "notes": {"original_bigg_ids": ["no2_c"]}, "charge": -1, "formula": "NO2", "compartment": "c", "id": "no2_c"}, {"name": "Nitrate", "notes": {"original_bigg_ids": ["no3_p"]}, "charge": -1, "formula": "NO3", "compartment": "p", "id": "no3_p"}, {"name": "Nitrate", "notes": {"original_bigg_ids": ["no3_c"]}, "charge": -1, "formula": "NO3", "compartment": "c", "id": "no3_c"}, {"name": "Novobiocin", "notes": {"original_bigg_ids": ["novbcn_p"]}, "charge": 0, "formula": "C31H36N2O11", "compartment": "p", "id": "novbcn_p"}, {"name": "Nitric oxide", "notes": {"original_bigg_ids": ["no_p"]}, "charge": 0, "formula": "NO", "compartment": "p", "id": "no_p"}, {"name": "Xanthosine", "notes": {"original_bigg_ids": ["xtsn_c"]}, "charge": 0, "formula": "C10H12N4O6", "compartment": "c", "id": "xtsn_c"}, {"name": "Xanthosine", "notes": {"original_bigg_ids": ["xtsn_p"]}, "charge": 0, "formula": "C10H12N4O6", "compartment": "p", "id": "xtsn_p"}, {"name": "Xanthosine 5'-phosphate", "notes": {"original_bigg_ids": ["xmp_p"]}, "charge": -2, "formula": "C10H11N4O9P", "compartment": "p", "id": "xmp_p"}, {"name": "DIMP", "notes": {"original_bigg_ids": ["dimp_c"]}, "charge": -2, "formula": "C10H11N4O7P", "compartment": "c", "id": "dimp_c"}, {"name": "UMP", "notes": {"original_bigg_ids": ["ump_p"]}, "charge": -2, "formula": "C9H11N2O9P", "compartment": "p", "id": "ump_p"}, {"name": "Thymidine", "notes": {"original_bigg_ids": ["thymd_c"]}, "charge": 0, "formula": "C10H14N2O5", "compartment": "c", "id": "thymd_c"}, {"name": "Thymidine", "notes": {"original_bigg_ids": ["thymd_p"]}, "charge": 0, "formula": "C10H14N2O5", "compartment": "p", "id": "thymd_p"}, {"name": "DIDP", "notes": {"original_bigg_ids": ["didp_c"]}, "charge": -3, "formula": "C10H11N4O10P2", "compartment": "c", "id": "didp_c"}, {"name": "XDP", "notes": {"original_bigg_ids": ["xdp_c"]}, "charge": -3, "formula": "C10H11N4O12P2", "compartment": "c", "id": "xdp_c"}, {"name": "(O16 antigen)x4 core oligosaccharide lipid A", "notes": {"original_bigg_ids": ["o16a4colipa_p"]}, "charge": -11, "formula": "C312H523N6O200P4", "compartment": "p", "id": "o16a4colipa_p"}, {"name": "Rhamanosyl-N-acetylglucosamyl-undecaprenyl diphosphate", "notes": {"original_bigg_ids": ["ragund_c"]}, "charge": -2, "formula": "C69H113N1O16P2", "compartment": "c", "id": "ragund_c"}, {"name": "O-acetyl-rhamanosyl-N-acetylglucosamyl-undecaprenyl diphosphate", "notes": {"original_bigg_ids": ["aragund_c"]}, "charge": -2, "formula": "C71H115N1O17P2", "compartment": "c", "id": "aragund_c"}, {"name": "Galactofuranosyl-glucosyl-O-acetyl-rhamanosyl-N-acetylglucosamyl-undecaprenyl diphosphate", "notes": {"original_bigg_ids": ["gfgaragund_c"]}, "charge": -2, "formula": "C83H135N1O27P2", "compartment": "c", "id": "gfgaragund_c"}, {"name": "O16 antigen undecaprenyl diphosphate", "notes": {"original_bigg_ids": ["o16aund_c"]}, "charge": -2, "formula": "C89H145N1O32P2", "compartment": "c", "id": "o16aund_c"}, {"name": "Superoxide anion", "notes": {"original_bigg_ids": ["o2s_p"]}, "charge": -1, "formula": "O2", "compartment": "p", "id": "o2s_p"}, {"name": "3-Hydroxyglutaryl-[acyl-carrier protein] methyl ester", "notes": {"original_bigg_ids": ["hgmeACP_c"]}, "charge": -1, "formula": "C17H29N2O11PRS", "compartment": "c", "id": "hgmeACP_c"}, {"name": "3-Oxo-glutaryl-[acyl-carrier protein] methyl ester", "notes": {"original_bigg_ids": ["ogmeACP_c"]}, "charge": -1, "formula": "C17H27N2O11PRS", "compartment": "c", "id": "ogmeACP_c"}, {"name": "2-Oxo-3-hydroxy-4-phosphobutanoate", "notes": {"original_bigg_ids": ["ohpb_c"]}, "charge": -3, "formula": "C4H4O8P", "compartment": "c", "id": "ohpb_c"}, {"name": "2-Octaprenyl-6-methoxyphenol", "notes": {"original_bigg_ids": ["2omph_c"]}, "charge": 0, "formula": "C47H72O2", "compartment": "c", "id": "2omph_c"}, {"name": "2-Octaprenyl-3-methyl-6-methoxy- 1,4-benzoquinol", "notes": {"original_bigg_ids": ["2ommbl_c"]}, "charge": 0, "formula": "C48H74O3", "compartment": "c", "id": "2ommbl_c"}, {"name": "2-Octaprenyl-6-methoxy-1,4-benzoquinol", "notes": {"original_bigg_ids": ["2ombzl_c"]}, "charge": 0, "formula": "C47H72O3", "compartment": "c", "id": "2ombzl_c"}, {"name": "Orotidine 5'-phosphate", "notes": {"original_bigg_ids": ["orot5p_c"]}, "charge": -3, "formula": "C10H10N2O11P", "compartment": "c", "id": "orot5p_c"}, {"name": "2-Octaprenylphenol", "notes": {"original_bigg_ids": ["2oph_c"]}, "charge": 0, "formula": "C46H70O", "compartment": "c", "id": "2oph_c"}, {"name": "3-Hydroxypimeloyl-[acyl-carrier protein] methyl ester", "notes": {"original_bigg_ids": ["hpmeACP_c"]}, "charge": -1, "formula": "C19H33N2O11PRS", "compartment": "c", "id": "hpmeACP_c"}, {"name": "3-Oxo-pimeloyl-[acyl-carrier protein] methyl ester", "notes": {"original_bigg_ids": ["opmeACP_c"]}, "charge": -1, "formula": "C19H31N2O11PRS", "compartment": "c", "id": "opmeACP_c"}, {"name": "Orotate", "notes": {"original_bigg_ids": ["orot_p"]}, "charge": -1, "formula": "C5H3N2O4", "compartment": "p", "id": "orot_p"}, {"name": "Oxalureate", "notes": {"original_bigg_ids": ["oxur_c"]}, "charge": -1, "formula": "C3H3N2O4", "compartment": "c", "id": "oxur_c"}, {"name": "Phenylacetaldehyde", "notes": {"original_bigg_ids": ["pacald_c"]}, "charge": 0, "formula": "C8H8O", "compartment": "c", "id": "pacald_c"}, {"name": "Phenylacetaldehyde", "notes": {"original_bigg_ids": ["pacald_p"]}, "charge": 0, "formula": "C8H8O", "compartment": "p", "id": "pacald_p"}, {"name": "(R)-Pantothenate", "notes": {"original_bigg_ids": ["pnto_DASH_R_c"]}, "charge": -1, "formula": "C9H16NO5", "compartment": "c", "id": "pnto__R_c"}, {"name": "Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine", "notes": {"original_bigg_ids": ["uagmda_c"]}, "charge": -4, "formula": "C87H139N7O23P2", "compartment": "c", "id": "uagmda_c"}, {"name": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine", "notes": {"original_bigg_ids": ["ugmda_c"]}, "charge": -4, "formula": "C41H61N9O28P2", "compartment": "c", "id": "ugmda_c"}, {"name": "Pyridoxine 5'-phosphate", "notes": {"original_bigg_ids": ["pdx5p_c"]}, "charge": -2, "formula": "C8H10NO6P", "compartment": "c", "id": "pdx5p_c"}, {"name": "Pyridoxine", "notes": {"original_bigg_ids": ["pydxn_c"]}, "charge": 0, "formula": "C8H11NO3", "compartment": "c", "id": "pydxn_c"}, {"name": "Phosphatidylethanolamine (didodecanoyl, n-C12:0)", "notes": {"original_bigg_ids": ["pe120_p"]}, "charge": 0, "formula": "C29H58N1O8P1", "compartment": "p", "id": "pe120_p"}, {"name": "Phosphatidylethanolamine (ditetradecanoyl, n-C14:0)", "notes": {"original_bigg_ids": ["pe140_p"]}, "charge": 0, "formula": "C33H66N1O8P1", "compartment": "p", "id": "pe140_p"}, {"name": "Phosphatidylethanolamine (ditetradec-7-enoyl, n-C14:1)", "notes": {"original_bigg_ids": ["pe141_p"]}, "charge": 0, "formula": "C33H62N1O8P1", "compartment": "p", "id": "pe141_p"}, {"name": "Phosphatidylethanolamine (dioctadecanoyl, n-C18:0)", "notes": {"original_bigg_ids": ["pe180_p"]}, "charge": 0, "formula": "C41H82N1O8P1", "compartment": "p", "id": "pe180_p"}, {"name": "Phenethylamine", "notes": {"original_bigg_ids": ["peamn_p"]}, "charge": 1, "formula": "C8H12N", "compartment": "p", "id": "peamn_p"}, {"name": "D-Tagatose 1,6-biphosphate", "notes": {"original_bigg_ids": ["tagdp_DASH_D_c"]}, "charge": -4, "formula": "C6H10O12P2", "compartment": "c", "id": "tagdp__D_c"}, {"name": "Sedoheptulose 7-phosphate", "notes": {"original_bigg_ids": ["s7p_c"]}, "charge": -2, "formula": "C7H13O10P", "compartment": "c", "id": "s7p_c"}, {"name": "3-Phosphohydroxypyruvate", "notes": {"original_bigg_ids": ["3php_c"]}, "charge": -3, "formula": "C3H2O7P", "compartment": "c", "id": "3php_c"}, {"name": "2-Phosphoglycolate", "notes": {"original_bigg_ids": ["2pglyc_c"]}, "charge": -3, "formula": "C2H2O6P", "compartment": "c", "id": "2pglyc_c"}, {"name": "Phosphatidylglycerophosphate (didodecanoyl, n-C12:0)", "notes": {"original_bigg_ids": ["pgp120_c"]}, "charge": -3, "formula": "C30H57O13P2", "compartment": "c", "id": "pgp120_c"}, {"name": "Phosphatidylglycerophosphate (didodecanoyl, n-C12:0)", "notes": {"original_bigg_ids": ["pgp120_p"]}, "charge": -3, "formula": "C30H57O13P2", "compartment": "p", "id": "pgp120_p"}, {"name": "Phosphatidylglycerophosphate (ditetradecanoyl, n-C14:0)", "notes": {"original_bigg_ids": ["pgp140_c"]}, "charge": -3, "formula": "C34H65O13P2", "compartment": "c", "id": "pgp140_c"}, {"name": "Phosphatidylglycerophosphate (ditetradecanoyl, n-C14:0)", "notes": {"original_bigg_ids": ["pgp140_p"]}, "charge": -3, "formula": "C34H65O13P2", "compartment": "p", "id": "pgp140_p"}, {"name": "Phosphatidylglycerophosphate (ditetradec-7-enoyl, n-C14:1)", "notes": {"original_bigg_ids": ["pgp141_p"]}, "charge": -3, "formula": "C34H61O13P2", "compartment": "p", "id": "pgp141_p"}, {"name": "Phosphatidylglycerophosphate (ditetradec-7-enoyl, n-C14:1)", "notes": {"original_bigg_ids": ["pgp141_c"]}, "charge": -3, "formula": "C34H61O13P2", "compartment": "c", "id": "pgp141_c"}, {"name": "Phosphatidylglycerophosphate (dihexadecanoyl, n-C16:0)", "notes": {"original_bigg_ids": ["pgp160_c"]}, "charge": -3, "formula": "C38H73O13P2", "compartment": "c", "id": "pgp160_c"}, {"name": "Phosphatidylglycerophosphate (dihexadecanoyl, n-C16:0)", "notes": {"original_bigg_ids": ["pgp160_p"]}, "charge": -3, "formula": "C38H73O13P2", "compartment": "p", "id": "pgp160_p"}, {"name": "Phosphatidylglycerophosphate (dihexadec-9-enoyl, n-C16:1)", "notes": {"original_bigg_ids": ["pgp161_p"]}, "charge": -3, "formula": "C38H69O13P2", "compartment": "p", "id": "pgp161_p"}, {"name": "Phosphatidylglycerophosphate (dihexadec-9-enoyl, n-C16:1)", "notes": {"original_bigg_ids": ["pgp161_c"]}, "charge": -3, "formula": "C38H69O13P2", "compartment": "c", "id": "pgp161_c"}, {"name": "Phosphatidylglycerophosphate (dioctadecanoyl, n-C18:0)", "notes": {"original_bigg_ids": ["pgp180_p"]}, "charge": -3, "formula": "C42H81O13P2", "compartment": "p", "id": "pgp180_p"}, {"name": "Phosphatidylglycerophosphate (dioctadecanoyl, n-C18:0)", "notes": {"original_bigg_ids": ["pgp180_c"]}, "charge": -3, "formula": "C42H81O13P2", "compartment": "c", "id": "pgp180_c"}, {"name": "Phosphatidylglycerophosphate (dioctadec-11-enoyl, n-C18:1)", "notes": {"original_bigg_ids": ["pgp181_c"]}, "charge": -3, "formula": "C42H77O13P2", "compartment": "c", "id": "pgp181_c"}, {"name": "Phosphatidylglycerophosphate (dioctadec-11-enoyl, n-C18:1)", "notes": {"original_bigg_ids": ["pgp181_p"]}, "charge": -3, "formula": "C42H77O13P2", "compartment": "p", "id": "pgp181_p"}, {"name": "Protoheme", "notes": {"original_bigg_ids": ["pheme_p"]}, "charge": -2, "formula": "C34H30FeN4O4", "compartment": "p", "id": "pheme_p"}, {"name": "Phenylpyruvate", "notes": {"original_bigg_ids": ["phpyr_c"]}, "charge": -1, "formula": "C9H7O3", "compartment": "c", "id": "phpyr_c"}, {"name": "TRNA(Phe)", "notes": {"original_bigg_ids": ["trnaphe_c"]}, "charge": 0, "formula": "R", "compartment": "c", "id": "trnaphe_c"}, {"name": "L-Phenylalanyl-tRNA(Phe)", "notes": {"original_bigg_ids": ["phetrna_c"]}, "charge": 1, "formula": "C9H10NOR", "compartment": "c", "id": "phetrna_c"}, {"name": "L-Phenylalanine", "notes": {"original_bigg_ids": ["phe_DASH_L_p"]}, "charge": 0, "formula": "C9H11NO2", "compartment": "p", "id": "phe__L_p"}, {"name": "4-(1-D-Ribitylamino)-5-aminouracil", "notes": {"original_bigg_ids": ["4r5au_c"]}, "charge": 0, "formula": "C9H16N4O6", "compartment": "c", "id": "4r5au_c"}, {"name": "D-4'-Phosphopantothenate", "notes": {"original_bigg_ids": ["4ppan_c"]}, "charge": -3, "formula": "C9H15NO8P", "compartment": "c", "id": "4ppan_c"}, {"name": "(R)-Pantothenate", "notes": {"original_bigg_ids": ["pnto_DASH_R_p"]}, "charge": -1, "formula": "C9H16NO5", "compartment": "p", "id": "pnto__R_p"}, {"name": "Peroxyaminoacrylate", "notes": {"original_bigg_ids": ["poaac_c"]}, "charge": 0, "formula": "C3H5NO3", "compartment": "c", "id": "poaac_c"}, {"name": "Propanoyl phosphate", "notes": {"original_bigg_ids": ["ppap_c"]}, "charge": -2, "formula": "C3H5O5P", "compartment": "c", "id": "ppap_c"}, {"name": "Propanal", "notes": {"original_bigg_ids": ["ppal_p"]}, "charge": 0, "formula": "C3H6O", "compartment": "p", "id": "ppal_p"}, {"name": "Propionate (n-C3:0)", "notes": {"original_bigg_ids": ["ppa_p"]}, "charge": -1, "formula": "C3H5O2", "compartment": "p", "id": "ppa_p"}, {"name": "Pantetheine 4'-phosphate", "notes": {"original_bigg_ids": ["pan4p_c"]}, "charge": -2, "formula": "C11H21N2O7PS", "compartment": "c", "id": "pan4p_c"}, {"name": "N-((R)-4-Phosphopantothenoyl)-L-cysteine", "notes": {"original_bigg_ids": ["4ppcys_c"]}, "charge": -3, "formula": "C12H20N2O9PS", "compartment": "c", "id": "4ppcys_c"}, {"name": "Alpha-D-Ribose 1-phosphate", "notes": {"original_bigg_ids": ["r1p_c"]}, "charge": -2, "formula": "C5H9O8P", "compartment": "c", "id": "r1p_c"}, {"name": "3-(4-Hydroxyphenyl)pyruvate", "notes": {"original_bigg_ids": ["34hpp_c"]}, "charge": -1, "formula": "C9H7O4", "compartment": "c", "id": "34hpp_c"}, {"name": "Phenylpropanoate", "notes": {"original_bigg_ids": ["pppn_c"]}, "charge": -1, "formula": "C9H9O2", "compartment": "c", "id": "pppn_c"}, {"name": "Phenylpropanoate", "notes": {"original_bigg_ids": ["pppn_p"]}, "charge": -1, "formula": 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"compartment": "p", "id": "oaa_p"}, {"name": "Tetrathionate", "notes": {"original_bigg_ids": ["tet_p"]}, "charge": -2, "formula": "O6S4", "compartment": "p", "id": "tet_p"}, {"name": "Pseudouridine 5  phosphate C9H11N2O9P", "notes": {"original_bigg_ids": ["psd5p_c"]}, "charge": -2, "formula": "C9H13N2O9P", "compartment": "c", "id": "psd5p_c"}, {"name": "O-antigen-x20-core-oligosaccharide-lipid-A", "notes": {"original_bigg_ids": ["colipa20Oag_e"]}, "charge": -11, "formula": "C656H1103N2O440P4", "compartment": "e", "id": "colipa20Oag_e"}, {"name": "2-Dehydro-3-deoxy-D-galactonate 6-phosphate", "notes": {"original_bigg_ids": ["2dh3dgal6p_c"]}, "charge": -3, "formula": "C6H8O9P", "compartment": "c", "id": "2dh3dgal6p_c"}, {"name": "2-3-dihydroxybenzoylserine trimer", "notes": {"original_bigg_ids": ["23dhbzs3_c"]}, "charge": 0, "formula": "C30H29N3O16", "compartment": "c", "id": "23dhbzs3_c"}, {"name": "Residual-atoms-of-reaction-DMBZIDSYN", "notes": {"original_bigg_ids": ["remnant1_e"]}, "charge": 0, "formula": "C4H2N2O3", "compartment": "e", "id": "remnant1_e"}, {"name": "D-Tagatose", "notes": {"original_bigg_ids": ["tag_DASH_D_p"]}, "charge": 0, "formula": "C6H12O6", "compartment": "p", "id": "tag__D_p"}, {"name": "N Ribosylnicotinamide C11H15N2O5", "notes": {"original_bigg_ids": ["rnam_e"]}, "charge": 1, "formula": "C11H15N2O5", "compartment": "e", "id": "rnam_e"}, {"name": "Cis-Aconitate", "notes": {"original_bigg_ids": ["acon_DASH_C_p"]}, "charge": -3, "formula": "C6H3O6", "compartment": "p", "id": "acon_C_p"}, {"name": "Ferrioxamine-G-fe", "notes": {"original_bigg_ids": ["feroxGfe_e"]}, "charge": 0, "formula": "C27H46FeN6O10", "compartment": "e", "id": "feroxGfe_e"}, {"name": "Salmochelin-S2", "notes": {"original_bigg_ids": ["salchs2_c"]}, "charge": 0, "formula": "C42H49N3O26", "compartment": "c", "id": "salchs2_c"}, {"name": "Salmochelin-S2-Fe-III", "notes": {"original_bigg_ids": ["salchs2fe_c"]}, "charge": 0, "formula": "C42FeH49N3O26", "compartment": "c", "id": "salchs2fe_c"}, {"name": "Cobalt-precorrin-2", "notes": {"original_bigg_ids": ["codscl2_c"]}, "charge": -7, "formula": "C42H39CoN4O16", "compartment": "c", "id": "codscl2_c"}, {"name": "Aminoimidazole-riboside", "notes": {"original_bigg_ids": ["airs_e"]}, "charge": 0, "formula": "C8H13N3O4", "compartment": "e", "id": "airs_e"}, {"name": "D-Glycerate 2-phosphate", "notes": {"original_bigg_ids": ["2pg_p"]}, "charge": -3, "formula": "C3H4O7P", "compartment": "p", "id": "2pg_p"}, {"name": "Undecaprenyl diphosphate galactose-rhamnose-mannose-abequose", "notes": {"original_bigg_ids": ["udcpo4_e"]}, "charge": -2, "formula": "C79H132O24P2", "compartment": "e", "id": "udcpo4_e"}, {"name": "Salmochelin-S2-Fe-III", "notes": {"original_bigg_ids": ["salchs2fe_p"]}, "charge": 0, "formula": "C42FeH49N3O26", "compartment": "p", "id": "salchs2fe_p"}, {"name": "Undecaprenyl diphosphate galactose-rhamnose-mannose-abequose-acetyl", "notes": {"original_bigg_ids": ["udcpo5_e"]}, "charge": -2, "formula": "C81H134O25P2", "compartment": "e", "id": "udcpo5_e"}, {"name": "2-Aminoethylphosphonate", "notes": {"original_bigg_ids": ["AEP_p"]}, "charge": -1, "formula": "C2H7N1O3P1", "compartment": "p", "id": "AEP_p"}, {"name": "Ferrioxamine-G", "notes": {"original_bigg_ids": ["feroxG_e"]}, "charge": 0, "formula": "C27H46N6O10", "compartment": "e", "id": "feroxG_e"}, {"name": "Formamide", "notes": {"original_bigg_ids": ["foam_p"]}, "charge": 0, "formula": "CH3NO", "compartment": "p", "id": "foam_p"}, {"name": "4-Hydroxy-benzyl alcohol", "notes": {"original_bigg_ids": ["4hba_c"]}, "charge": 0, "formula": "C7H8O2", "compartment": "c", "id": "4hba_c"}, {"notes": {"original_bigg_ids": ["diact_e"]}, "compartment": "e", "name": "Diacetyl", "charge": 0, "id": "diact_e"}, {"notes": {"original_bigg_ids": ["indpyr_c"]}, "compartment": "c", "name": "Indolepyruvate C11H8NO3", "charge": 0, "id": "indpyr_c"}, {"notes": {"original_bigg_ids": ["5aptn_c"]}, "compartment": "c", "name": "5-Aminopentanoate", "charge": 0, "id": "5aptn_c"}, {"notes": {"original_bigg_ids": ["pprdn_c"]}, "compartment": "c", "name": "Piperideine", "charge": 0, "id": "pprdn_c"}, {"notes": {"original_bigg_ids": ["cellb_e"]}, "compartment": "e", "name": "Cellobiose", "charge": 0, "id": "cellb_e"}, {"notes": {"original_bigg_ids": ["btd_DASH_RR_e"]}, "compartment": "e", "name": " R R  2 3 Butanediol C4H10O2", "charge": 0, "id": "btd_RR_e"}, {"notes": {"original_bigg_ids": ["13ppd_e"]}, "compartment": "e", "name": "1,3-Propanediol", "charge": 0, "id": "13ppd_e"}, {"notes": {"original_bigg_ids": ["rbt_e"]}, "compartment": "e", "name": "Ribitol", "charge": 0, "id": "rbt_e"}, {"notes": {"original_bigg_ids": ["glutar_c"]}, "compartment": "c", "name": "Glutarate", "charge": 0, "id": "glutar_c"}, {"notes": {"original_bigg_ids": ["oxptn_c"]}, "compartment": "c", "name": "5-Oxopentanoate", "charge": 0, "id": "oxptn_c"}, {"notes": {"original_bigg_ids": ["bz_e"]}, "compartment": "e", "name": "Benzoate", "charge": 0, "id": "bz_e"}, {"name": "3-Oxoadipyl-CoA", "notes": {"original_bigg_ids": ["oxadpcoa_c"]}, "charge": -5, "formula": "C27H37N7O20P3S", "compartment": "c", "id": "oxadpcoa_c"}, {"notes": {"original_bigg_ids": ["glutcoa_c"]}, "compartment": "c", "name": "Glutaryl-CoA", "charge": 0, "id": "glutcoa_c"}, {"notes": {"original_bigg_ids": ["abt_DASH_D_e"]}, "compartment": "e", "name": "D-Arabitol", "charge": 0, "id": "abt__D_e"}, {"name": "4-Hydroxyphenylacetate", "notes": {"original_bigg_ids": ["4hphac_p"]}, "charge": -1, "formula": "C8H7O3", "compartment": "p", "id": "4hphac_p"}, {"notes": {"original_bigg_ids": ["4hphac_c"]}, "compartment": "c", "name": "4-Hydroxyphenylacetate", "charge": 0, "id": "4hphac_c"}, {"name": "2(alpha-D-Mannosyl-6-phosphate)-D-glycerate", "notes": {"original_bigg_ids": ["man6pglyc_c"]}, "charge": -3, "formula": "C9H14O12P", "compartment": "c", "id": "man6pglyc_c"}, {"name": "D-Allose", "notes": {"original_bigg_ids": ["all_DASH_D_c"]}, "charge": 0, "formula": "C6H12O6", "compartment": "c", "id": "all__D_c"}, {"name": "Cyclic diguanosine monophosphate", "notes": {"original_bigg_ids": ["cdigmp_c"]}, "charge": 0, "formula": "C20H22N10O14P2", "compartment": "c", "id": "cdigmp_c"}, {"name": "S-Methyl-L-methionine", "notes": {"original_bigg_ids": ["mmet_c"]}, "charge": 1, "formula": "C6H14NO2S", "compartment": "c", "id": "mmet_c"}, {"name": "Acetoacetate", "notes": {"original_bigg_ids": ["acac_c"]}, "charge": -1, "formula": "C4H5O3", "compartment": "c", "id": "acac_c"}, {"name": "Fe p", "notes": {"original_bigg_ids": ["fe_e"]}, "charge": 0, "formula": "Fe", "compartment": "e", "id": "fe_e"}, {"name": "KO-KDO-LIPID A", "notes": {"original_bigg_ids": ["kokdolipidA_e"]}, "charge": 0, "formula": "C110H196N2O40P2", "compartment": "e", "id": "kokdolipidA_e"}, {"name": "D Galactosamine 6 phosphate C6H14NO8P", "notes": {"original_bigg_ids": ["galam6p_c"]}, "charge": 0, "formula": "C6H14NO8P", "compartment": "c", "id": "galam6p_c"}, {"name": "Sucrose", "notes": {"original_bigg_ids": ["sucr_c"]}, "charge": 0, "formula": "C12H22O11", "compartment": "c", "id": "sucr_c"}, {"name": "Cellobiose", "notes": {"original_bigg_ids": ["cellb_p"]}, "charge": 0, "formula": "C12H22O11", "compartment": "p", "id": "cellb_p"}, {"name": "3 Hydroxyphenylacetic acid C8H8O3", "notes": {"original_bigg_ids": ["3hoxpac_e"]}, "charge": 0, "formula": "C8H8O3", "compartment": "e", "id": "3hoxpac_e"}, {"name": "Penicillin G C16H18N2O4S", "notes": {"original_bigg_ids": ["peng_p"]}, "charge": 0, "formula": "C16H18N2O4S", "compartment": "p", "id": "peng_p"}, {"name": "Penicillin G C16H18N2O4S", "notes": {"original_bigg_ids": ["peng_e"]}, "charge": 0, "formula": "C16H18N2O4S", "compartment": "e", "id": "peng_e"}, {"name": "Raffinose C18H32O16", "notes": {"original_bigg_ids": ["raffin_p"]}, "charge": 0, "formula": "C18H32O16", "compartment": "p", "id": "raffin_p"}, {"name": "Raffinose C18H32O16", "notes": {"original_bigg_ids": ["raffin_e"]}, "charge": 0, "formula": "C18H32O16", "compartment": "e", "id": "raffin_e"}, {"name": "D Galactosamine C6H13NO5", "notes": {"original_bigg_ids": ["galam_p"]}, "charge": 0, "formula": "C6H13NO5", "compartment": "p", "id": "galam_p"}, {"name": "4 Hydroxyphenylacetic acid C8H8O3", "notes": {"original_bigg_ids": ["4hoxpac_e"]}, "charge": 0, "formula": "C8H8O3", "compartment": "e", "id": "4hoxpac_e"}, {"name": "3 Hydroxyphenylacetic acid C8H8O3", "notes": {"original_bigg_ids": ["3hoxpac_p"]}, "charge": 0, "formula": "C8H8O3", "compartment": "p", "id": "3hoxpac_p"}, {"name": "6 Aminopenicillanic acid C8H12N2O3S", "notes": {"original_bigg_ids": ["6apa_e"]}, "charge": 0, "formula": "C8H12N2O3S", "compartment": "e", "id": "6apa_e"}, {"name": "6 Aminopenicillanic acid C8H12N2O3S", "notes": {"original_bigg_ids": ["6apa_p"]}, "charge": 0, "formula": "C8H12N2O3S", "compartment": "p", "id": "6apa_p"}, {"name": "(R)-Methylmalonyl-CoA", "notes": {"original_bigg_ids": ["mmcoa_R_c"]}, "charge": 0, "formula": "C25H35N7O19P3S", "compartment": "c", "id": "mmcoa__R_c"}, {"name": "D Galactosamine C6H13NO5", "notes": {"original_bigg_ids": ["galam_e"]}, "charge": 0, "formula": "C6H13NO5", "compartment": "e", "id": "galam_e"}, {"name": "1' Phosphoethanolamin lipidIVa C70H132N3O26P3", "notes": {"original_bigg_ids": ["enlipidA_LptA_p"]}, "charge": 0, "formula": "C70H132N3O26P3", "compartment": "p", "id": "enlipidA_LptA_p"}, {"notes": {"original_bigg_ids": ["LptA_p"]}, "compartment": "p", "name": "Periplasmic lipid A binding protein ", "charge": 0, "id": "LptA_p"}, {"name": "1' Phosphoethanolamin lipidIVa C70H132N3O26P3", "notes": {"original_bigg_ids": ["enlipidA_p"]}, "charge": 0, "formula": "C70H132N3O26P3", "compartment": "p", "id": "enlipidA_p"}, {"name": "3 Nitrotyramine C8H15N2", "notes": {"original_bigg_ids": ["3ntym_e"]}, "charge": 0, "formula": "C8H15N2", "compartment": "e", "id": "3ntym_e"}, {"name": "Salicin", "notes": {"original_bigg_ids": ["salcn_e"]}, "charge": 0, "formula": "C13H18O7", "compartment": "e", "id": "salcn_e"}, {"name": "Salicin", "notes": {"original_bigg_ids": ["salcn_p"]}, "charge": 0, "formula": "C13H18O7", "compartment": "p", "id": "salcn_p"}, {"name": "1' Phosphoethanolamin lipidIVa C70H132N3O26P3", "notes": {"original_bigg_ids": ["enlipidA_e"]}, "charge": 0, "formula": "C70H132N3O26P3", "compartment": "e", "id": "enlipidA_e"}, {"name": "Phenylacetic acid", "notes": {"original_bigg_ids": ["pac_e"]}, "charge": 0, "formula": "C8H7O2", "compartment": "e", "id": "pac_e"}, {"name": "N Acetyl D galactosamine 6 phosphate C8H16NO9P", "notes": {"original_bigg_ids": ["acgal6p_c"]}, "charge": 0, "formula": "C8H16NO9P", "compartment": "c", "id": "acgal6p_c"}, {"name": "2 3 2'3' Tetrakis beta hydroxymyristoyl  D glucosaminyl 1 6 beta D glucosamine 1 4' bisphosphate C68H126N2O23P2", "notes": {"original_bigg_ids": ["lipidA_core_e_p"]}, "charge": 0, "formula": "C68H126N2O23P2", "compartment": "p", "id": "lipidA_core_e_p"}, {"name": "Phenylacetic acid", "notes": {"original_bigg_ids": ["pac_p"]}, "charge": 0, "formula": "C8H7O2", "compartment": "p", "id": "pac_p"}, {"name": " O6 antigen x4 core oligosaccharide lipid A O225H390N2O120P2", "notes": {"original_bigg_ids": ["o6a4colipa_e"]}, "charge": 0, "formula": "O225H390N2O120P2", "compartment": "e", "id": "o6a4colipa_e"}, {"name": "D Arabinose C5H10O5", "notes": {"original_bigg_ids": ["arab_DASH_D_p"]}, "charge": 0, "formula": "C5H10O5", "compartment": "p", "id": "arab__D_p"}, {"name": "D Arabinose C5H10O5", "notes": {"original_bigg_ids": ["arab_DASH_D_c"]}, "charge": 0, "formula": "C5H10O5", "compartment": "c", "id": "arab__D_c"}, {"name": "D-Ribulose", "notes": {"original_bigg_ids": ["rbl_DASH_D_c"]}, "charge": 0, "formula": "C5H10O5", "compartment": "c", "id": "rbl__D_c"}, {"name": "D Arabinose C5H10O5", "notes": {"original_bigg_ids": ["arab_DASH_D_e"]}, "charge": 0, "formula": "C5H10O5", "compartment": "e", "id": "arab__D_e"}, {"notes": {"original_bigg_ids": ["udpacgal_c"]}, "compartment": 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