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-1.0, "akg_e": 1.0}, "id": "AKGMAL", "gene_reaction_rule": ""}, {"subsystem": "S_Transport__Nuclear", "name": "2 oxoglutarate nuclear transport via proton symport", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["AKGt2n"]}, "metabolites": {"h_n": 1.0, "akg_c": -1.0, "akg_n": 1.0, "h_c": -1.0}, "id": "AKGt2n", "gene_reaction_rule": ""}, {"subsystem": "S_Transport__Extracellular", "name": "2 oxoglutarate reversible transport via symport", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["AKGt2r"]}, "metabolites": {"akg_c": 1.0, "h_e": -1.0, "h_c": 1.0, "akg_e": -1.0}, "id": "AKGt2r", "gene_reaction_rule": ""}, {"subsystem": "S_Transport__Peroxisomal", "name": "AKG transporter peroxisome", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["AKGtp"]}, "metabolites": {"akg_c": -1.0, "akg_x": 1.0}, "id": "AKGtp", "gene_reaction_rule": ""}, {"subsystem": "S_Folate_Metabolism", "name": "Alkaline phosphatase Dihydroneopterin ", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AKP1"]}, "metabolites": {"dhnpt_c": 1.0, "h2o_c": -3.0, "pi_c": 3.0, "h_c": 2.0, "ahdt_c": -1.0}, "id": "AKP1", "gene_reaction_rule": "YDR481C"}, {"subsystem": "S_Porphyrin_and_Chlorophyll_Metabolism", "name": "5 aminolevulinate synthase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALASm"]}, "metabolites": {"succoa_m": -1.0, "gly_m": -1.0, "co2_m": 1.0, "coa_m": 1.0, "h_m": -1.0, "5aop_m": 1.0}, "id": "ALASm", "gene_reaction_rule": "YDR232W"}, {"subsystem": "S_Alanine_and_Aspartate_Metabolism", "name": "L-alanine transaminase", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ALATA_L"]}, "metabolites": {"akg_c": -1.0, "pyr_c": 1.0, "ala__L_c": -1.0, "glu__L_c": 1.0}, "id": "ALATA_L", "gene_reaction_rule": "YDR111C"}, {"subsystem": "S_Alanine_and_Aspartate_Metabolism", "name": "L alanine transaminase mitochondrial", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ALATA_Lm"]}, "metabolites": {"pyr_m": 1.0, "ala__L_m": -1.0, "glu__L_m": 1.0, "akg_m": -1.0}, "id": "ALATA_Lm", "gene_reaction_rule": "YLR089C"}, {"subsystem": "S_tRNA_charging", "name": "Alanyl-tRNA synthetase", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALATRS"]}, "metabolites": {"trnaala_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "ala__L_c": -1.0, "amp_c": 1.0, "alatrna_c": 1.0}, "id": "ALATRS", "gene_reaction_rule": "YOR335C"}, {"subsystem": "S_Transport__Extracellular", "name": "L alanine reversible transport via proton symport", "upper_bound": 999999.0, "lower_bound": -999999.0, "notes": {"original_bigg_ids": ["ALAt2r"]}, "metabolites": {"ala__L_e": -1.0, "h_e": -1.0, "ala__L_c": 1.0, "h_c": 1.0}, "id": "ALAt2r", "gene_reaction_rule": "YKR039W or YPL265W or YCL025C or YOL020W or YOR348C"}, {"subsystem": "S_Transport__Mitochondrial", "name": "Alanine 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"Aldehyde dehydrogenase 2 methylbutanol NAD mitochondrial", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALCD22xim"]}, "metabolites": {"2mbald_m": -1.0, "nad_m": 1.0, "h_m": -1.0, "nadh_m": -1.0, "2mbtoh_m": 1.0}, "id": "ALCD22xim", "gene_reaction_rule": "YMR083W"}, {"subsystem": "S_Complex_Alcohol_Metabolism", "name": "Aldehyde dehydrogenase 2 methylbutanol NADP ", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALCD22yi"]}, "metabolites": {"2mbtoh_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "2mbald_c": -1.0}, "id": "ALCD22yi", "gene_reaction_rule": "YDR368W or YMR318C or YBR036C"}, {"subsystem": "S_Complex_Alcohol_Metabolism", "name": "Aldehyde dehydrogenase isobutyl alcohol NAD ", "upper_bound": 999999.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALCD23xi"]}, "metabolites": {"2mppal_c": -1.0, "nadh_c": -1.0, "ibutoh_c": 1.0, "nad_c": 1.0, "h_c": -1.0}, "id": "ALCD23xi", "gene_reaction_rule": "YGL256W 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"compartment": "c", "id": "2ippm_c"}, {"name": "2-keto-4-methylthiobutyrate", "notes": {"original_bigg_ids": ["2kmb_c"]}, "charge": -1, "formula": "C5H7O3S", "compartment": "c", "id": "2kmb_c"}, {"name": "2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate", "notes": {"original_bigg_ids": ["2mahmp_c"]}, "charge": -3, "formula": "C6H8N3O7P2", "compartment": "c", "id": "2mahmp_c"}, {"name": "2 methylbutyl acetate C7H14O2", "notes": {"original_bigg_ids": ["2mbac_c"]}, "charge": 0, "formula": "C7H14O2", "compartment": "c", "id": "2mbac_c"}, {"name": "2 methylbutyl acetate C7H14O2", "notes": {"original_bigg_ids": ["2mbac_e"]}, "charge": 0, "formula": "C7H14O2", "compartment": "e", "id": "2mbac_e"}, {"name": "2 methylbutyraldehyde C5H10O", "notes": {"original_bigg_ids": ["2mbald_c"]}, "charge": 0, "formula": "C5H10O", "compartment": "c", "id": "2mbald_c"}, {"name": "2 methylbutyraldehyde C5H10O", "notes": {"original_bigg_ids": ["2mbald_e"]}, "charge": 0, "formula": "C5H10O", 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hydroxybenoyl CoA C28H36N7O18P3S", "notes": {"original_bigg_ids": ["4hbzcoa_m"]}, "charge": -4, "formula": "C28H36N7O18P3S", "compartment": "m", "id": "4hbzcoa_m"}, {"name": "L 4 Hydroxyglutamate semialdehyde C5H9NO4", "notes": {"original_bigg_ids": ["4hglusa_m"]}, "charge": 0, "formula": "C5H9NO4", "compartment": "m", "id": "4hglusa_m"}, {"name": "Trans 4 Hydroxy L proline C5H9NO3", "notes": {"original_bigg_ids": ["4hpro_LT_c"]}, "charge": 0, "formula": "C5H9NO3", "compartment": "c", "id": "4hpro_LT_c"}, {"name": "Trans 4 Hydroxy L proline C5H9NO3", "notes": {"original_bigg_ids": ["4hpro_LT_m"]}, "charge": 0, "formula": "C5H9NO3", "compartment": "m", "id": "4hpro_LT_m"}, {"name": "4-Hydroxy-L-threonine", "notes": {"original_bigg_ids": ["4hthr_c"]}, "charge": 0, "formula": "C4H9NO4", "compartment": "c", "id": "4hthr_c"}, {"name": "4-Methyl-5-(2-hydroxyethyl)-thiazole", "notes": {"original_bigg_ids": ["4mhetz_c"]}, "charge": 0, "formula": "C6H9NOS", "compartment": "c", "id": 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"nadh_c"}, {"name": "Nicotinamide adenine dinucleotide - reduced", "notes": {"original_bigg_ids": ["nadh_m"]}, "charge": -2, "formula": "C21H27N7O14P2", "compartment": "m", "id": "nadh_m"}, {"name": "Nicotinamide adenine dinucleotide - reduced", "notes": {"original_bigg_ids": ["nadh_r"]}, "charge": -2, "formula": "C21H27N7O14P2", "compartment": "r", "id": "nadh_r"}, {"name": "Nicotinamide adenine dinucleotide - reduced", "notes": {"original_bigg_ids": ["nadh_x"]}, "charge": -2, "formula": "C21H27N7O14P2", "compartment": "x", "id": "nadh_x"}, {"name": "Nicotinamide adenine dinucleotide phosphate", "notes": {"original_bigg_ids": ["nadp_c"]}, "charge": -3, "formula": "C21H25N7O17P3", "compartment": "c", "id": "nadp_c"}, {"name": "Nicotinamide adenine dinucleotide phosphate", "notes": {"original_bigg_ids": ["nadp_e"]}, "charge": -3, "formula": "C21H25N7O17P3", "compartment": "e", "id": "nadp_e"}, {"name": "Nicotinamide adenine dinucleotide phosphate", "notes": {"original_bigg_ids": ["nadp_m"]}, "charge": -3, "formula": "C21H25N7O17P3", "compartment": "m", "id": "nadp_m"}, {"name": "Nicotinamide adenine dinucleotide phosphate", "notes": {"original_bigg_ids": ["nadp_r"]}, "charge": -3, "formula": "C21H25N7O17P3", "compartment": "r", "id": "nadp_r"}, {"name": "Nicotinamide adenine dinucleotide phosphate", "notes": {"original_bigg_ids": ["nadp_x"]}, "charge": -3, "formula": "C21H25N7O17P3", "compartment": "x", "id": "nadp_x"}, {"name": "Nicotinamide adenine dinucleotide phosphate - reduced", "notes": {"original_bigg_ids": ["nadph_c"]}, "charge": -4, "formula": "C21H26N7O17P3", "compartment": "c", "id": "nadph_c"}, {"name": "Nicotinamide adenine dinucleotide phosphate - reduced", "notes": {"original_bigg_ids": ["nadph_m"]}, "charge": -4, "formula": "C21H26N7O17P3", "compartment": "m", "id": "nadph_m"}, {"name": "Nicotinamide adenine dinucleotide phosphate - reduced", "notes": {"original_bigg_ids": ["nadph_r"]}, "charge": -4, "formula": "C21H26N7O17P3", "compartment": "r", "id": "nadph_r"}, {"name": "Nicotinamide adenine dinucleotide phosphate - reduced", "notes": {"original_bigg_ids": ["nadph_x"]}, "charge": -4, "formula": "C21H26N7O17P3", "compartment": "x", "id": "nadph_x"}, {"name": "Nicotinamide", "notes": {"original_bigg_ids": ["ncam_c"]}, "charge": 0, "formula": "C6H6N2O", "compartment": "c", "id": "ncam_c"}, {"name": "Nicotinamide", "notes": {"original_bigg_ids": ["ncam_m"]}, "charge": 0, "formula": "C6H6N2O", "compartment": "m", "id": "ncam_m"}, {"name": "Ammonium", "notes": {"original_bigg_ids": ["nh4_c"]}, "charge": 1, "formula": "H4N", "compartment": "c", "id": "nh4_c"}, {"name": "Ammonium", "notes": {"original_bigg_ids": ["nh4_e"]}, "charge": 1, "formula": "H4N", "compartment": "e", "id": "nh4_e"}, {"name": "Ammonium", "notes": {"original_bigg_ids": ["nh4_m"]}, "charge": 1, "formula": "H4N", "compartment": "m", "id": "nh4_m"}, {"name": "Ammonium", "notes": {"original_bigg_ids": ["nh4_n"]}, "charge": 1, "formula": "H4N", "compartment": "n", "id": "nh4_n"}, {"name": "Ammonium", "notes": {"original_bigg_ids": ["nh4_x"]}, "charge": 1, "formula": "H4N", "compartment": "x", "id": "nh4_x"}, {"name": "Nicotinate D-ribonucleotide", "notes": {"original_bigg_ids": ["nicrnt_c"]}, "charge": -2, "formula": "C11H12NO9P", "compartment": "c", "id": "nicrnt_c"}, {"name": "Nicotinate D-ribonucleotide", "notes": {"original_bigg_ids": ["nicrnt_m"]}, "charge": -2, "formula": "C11H12NO9P", "compartment": "m", "id": "nicrnt_m"}, {"name": "NMN", "notes": {"original_bigg_ids": ["nmn_c"]}, "charge": -1, "formula": "C11H14N2O8P", "compartment": "c", "id": "nmn_c"}, {"name": "NMN", "notes": {"original_bigg_ids": ["nmn_e"]}, "charge": -1, "formula": "C11H14N2O8P", "compartment": "e", "id": "nmn_e"}, {"name": "NMN", "notes": {"original_bigg_ids": ["nmn_m"]}, "charge": -1, "formula": "C11H14N2O8P", "compartment": "m", "id": "nmn_m"}, {"name": "NMN", "notes": {"original_bigg_ids": ["nmn_x"]}, "charge": -1, "formula": "C11H14N2O8P", "compartment": "x", "id": "nmn_x"}, {"name": "O2", "notes": {"original_bigg_ids": ["o2_c"]}, "charge": 0, "formula": "O2", "compartment": "c", "id": "o2_c"}, {"name": "O2", "notes": {"original_bigg_ids": ["o2_e"]}, "charge": 0, "formula": "O2", "compartment": "e", "id": "o2_e"}, {"name": "O2", "notes": {"original_bigg_ids": ["o2_m"]}, "charge": 0, "formula": "O2", "compartment": "m", "id": "o2_m"}, {"name": "O2", "notes": {"original_bigg_ids": ["o2_r"]}, "charge": 0, "formula": "O2", "compartment": "r", "id": "o2_r"}, {"name": "O2", "notes": {"original_bigg_ids": ["o2_x"]}, "charge": 0, "formula": "O2", "compartment": "x", "id": "o2_x"}, {"name": "Oxaloacetate", "notes": {"original_bigg_ids": ["oaa_c"]}, "charge": -2, "formula": "C4H2O5", "compartment": "c", "id": "oaa_c"}, {"name": "Oxaloacetate", "notes": {"original_bigg_ids": ["oaa_e"]}, "charge": -2, "formula": "C4H2O5", "compartment": "e", "id": "oaa_e"}, {"name": "Oxaloacetate", "notes": {"original_bigg_ids": ["oaa_m"]}, "charge": -2, "formula": "C4H2O5", "compartment": "m", "id": "oaa_m"}, {"name": "Oxaloacetate", "notes": {"original_bigg_ids": ["oaa_x"]}, "charge": -2, "formula": "C4H2O5", "compartment": "x", "id": "oaa_x"}, {"name": "Octanoyl-ACP (n-C8:0ACP)", "notes": {"original_bigg_ids": ["ocACP_m"]}, "charge": -1, "formula": "C19H35N2O8PRS", "compartment": "m", "id": "ocACP_m"}, {"name": "Octanoyl-CoA (n-C8:0CoA)", "notes": {"original_bigg_ids": ["occoa_c"]}, "charge": -4, "formula": "C29H46N7O17P3S", "compartment": "c", "id": "occoa_c"}, {"name": "Octanoyl-CoA (n-C8:0CoA)", "notes": {"original_bigg_ids": ["occoa_x"]}, "charge": -4, "formula": "C29H46N7O17P3S", "compartment": "x", "id": "occoa_x"}, {"name": "Octadecanoyl-ACP (n-C18:0ACP)", "notes": {"original_bigg_ids": ["ocdcaACP_c"]}, "charge": -1, "formula": "C29H55N2O8PRS", "compartment": "c", "id": "ocdcaACP_c"}, {"name": "Octadecanoyl-ACP (n-C18:0ACP)", "notes": {"original_bigg_ids": ["ocdcaACP_m"]}, "charge": -1, "formula": "C29H55N2O8PRS", "compartment": "m", "id": "ocdcaACP_m"}, {"name": "Octadecanoate (n-C18:0)", "notes": {"original_bigg_ids": ["ocdca_c"]}, "charge": -1, "formula": "C18H35O2", "compartment": "c", "id": "ocdca_c"}, {"name": "Octadecanoate (n-C18:0)", "notes": {"original_bigg_ids": ["ocdca_e"]}, "charge": -1, "formula": "C18H35O2", "compartment": "e", "id": "ocdca_e"}, {"name": "Octadecanoate (n-C18:0)", "notes": {"original_bigg_ids": ["ocdca_x"]}, "charge": -1, "formula": "C18H35O2", "compartment": "x", "id": "ocdca_x"}, {"name": "Octadecenoate (n-C18:1)", "notes": {"original_bigg_ids": ["ocdcea_c"]}, "charge": -1, "formula": "C18H33O2", "compartment": "c", "id": "ocdcea_c"}, {"name": "Octadecenoate (n-C18:1)", "notes": {"original_bigg_ids": ["ocdcea_e"]}, "charge": -1, "formula": "C18H33O2", "compartment": "e", "id": "ocdcea_e"}, {"name": "Octadecynoyl ACP n C182ACP C29H51N2O8PRS", "notes": {"original_bigg_ids": ["ocdcyaACP_c"]}, "charge": -1, "formula": "C29H51N2O8PRS", "compartment": "c", "id": "ocdcyaACP_c"}, {"name": "Octadecynoyl ACP n C182ACP C29H51N2O8PRS", "notes": {"original_bigg_ids": ["ocdcyaACP_m"]}, "charge": -1, "formula": "C29H51N2O8PRS", "compartment": "m", "id": "ocdcyaACP_m"}, {"name": "Octadecadienoate n C182 C18H31O2", "notes": {"original_bigg_ids": ["ocdcya_c"]}, "charge": -1, "formula": "C18H31O2", "compartment": "c", "id": "ocdcya_c"}, {"name": "Octadecadienoate n C182 C18H31O2", "notes": {"original_bigg_ids": ["ocdcya_e"]}, "charge": -1, "formula": "C18H31O2", "compartment": "e", "id": "ocdcya_e"}, {"name": "Octadecynoyl CoA n C182CoA C39H62N7O17P3S", "notes": {"original_bigg_ids": ["ocdycacoa_c"]}, "charge": -4, "formula": "C39H62N7O17P3S", "compartment": "c", "id": "ocdycacoa_c"}, {"name": "Octadecynoyl CoA n C182CoA C39H62N7O17P3S", "notes": {"original_bigg_ids": ["ocdycacoa_x"]}, "charge": -4, "formula": "C39H62N7O17P3S", "compartment": "x", "id": "ocdycacoa_x"}, {"name": "Octanoate (n-C8:0)", "notes": {"original_bigg_ids": ["octa_c"]}, "charge": -1, "formula": "C8H15O2", "compartment": "c", "id": "octa_c"}, {"name": "Octanoate (n-C8:0)", "notes": {"original_bigg_ids": ["octa_x"]}, "charge": -1, "formula": "C8H15O2", "compartment": "x", "id": "octa_x"}, {"name": "Cis-octadec-11-enoyl-[acyl-carrier protein] (n-C18:1)", "notes": {"original_bigg_ids": ["octeACP_c"]}, "charge": -1, "formula": "C29H53N2O8PRS", "compartment": "c", "id": "octeACP_c"}, {"name": "Cis-octadec-11-enoyl-[acyl-carrier protein] (n-C18:1)", "notes": {"original_bigg_ids": ["octeACP_m"]}, "charge": -1, "formula": "C29H53N2O8PRS", "compartment": "m", "id": "octeACP_m"}, {"name": "Trans-Octadec-2-enoyl-CoA", "notes": {"original_bigg_ids": ["od2coa_x"]}, "charge": -4, "formula": "C39H64N7O17P3S", "compartment": "x", "id": "od2coa_x"}, {"name": "Octadecenoyl-CoA (n-C18:1CoA)", "notes": {"original_bigg_ids": ["odecoa_c"]}, "charge": -4, "formula": "C39H64N7O17P3S", "compartment": "c", "id": "odecoa_c"}, {"name": "Octadecenoyl-CoA (n-C18:1CoA)", "notes": {"original_bigg_ids": ["odecoa_x"]}, "charge": -4, "formula": "C39H64N7O17P3S", "compartment": "x", "id": "odecoa_x"}, {"name": "Hydroxide ion HO", "notes": {"original_bigg_ids": ["oh1_c"]}, "charge": -1, "formula": "HO", "compartment": "c", "id": "oh1_c"}, {"name": "Hydroxide ion HO", "notes": {"original_bigg_ids": ["oh1_m"]}, "charge": -1, "formula": "HO", "compartment": "m", "id": "oh1_m"}, {"name": "2-Oxo-3-hydroxy-4-phosphobutanoate", "notes": {"original_bigg_ids": ["ohpb_c"]}, "charge": -3, "formula": "C4H4O8P", "compartment": "c", "id": "ohpb_c"}, {"name": "Ornithine", "notes": {"original_bigg_ids": ["orn_c"]}, "charge": 1, "formula": "C5H13N2O2", "compartment": "c", "id": "orn_c"}, {"name": "Ornithine", "notes": {"original_bigg_ids": ["orn_e"]}, "charge": 1, "formula": "C5H13N2O2", "compartment": "e", "id": "orn_e"}, {"name": "Ornithine", "notes": {"original_bigg_ids": ["orn_m"]}, "charge": 1, "formula": "C5H13N2O2", "compartment": "m", "id": "orn_m"}, {"name": "Orotidine 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{"name": "Adenosine 3',5'-bisphosphate", "notes": {"original_bigg_ids": ["pap_e"]}, "charge": -4, "formula": "C10H11N5O10P2", "compartment": "e", "id": "pap_e"}, {"name": "Adenosine 3',5'-bisphosphate", "notes": {"original_bigg_ids": ["pap_m"]}, "charge": -4, "formula": "C10H11N5O10P2", "compartment": "m", "id": "pap_m"}, {"name": "Adenosine 3',5'-bisphosphate", "notes": {"original_bigg_ids": ["pap_x"]}, "charge": -4, "formula": "C10H11N5O10P2", "compartment": "x", "id": "pap_x"}, {"name": "3'-Phosphoadenylyl sulfate", "notes": {"original_bigg_ids": ["paps_c"]}, "charge": -4, "formula": "C10H11N5O13P2S", "compartment": "c", "id": "paps_c"}, {"name": "Phosphatidylcholine yeast specific C4040H7844N100O800P100", "notes": {"original_bigg_ids": ["pc_SC_c"]}, "charge": 0, "formula": "C4040H7844N100O800P100", "compartment": "c", "id": "pc_SC_c"}, {"name": "Phosphatidylcholine yeast specific C4040H7844N100O800P100", "notes": {"original_bigg_ids": ["pc_SC_e"]}, "charge": 0, "formula": 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