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{"arbt_e": -1.0}, "id": "EX_arbt_e", "gene_reaction_rule": ""}, {"name": "Aerobactin minus Fe3 exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_arbtn_LPAREN_e_RPAREN_"]}, "metabolites": {"arbtn_e": -1.0}, "id": "EX_arbtn_e", "gene_reaction_rule": ""}, {"name": "Aerobactin exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_arbtn_DASH_fe3_LPAREN_e_RPAREN_"]}, "metabolites": {"arbtn_fe3_e": -1.0}, "id": "EX_arbtn_fe3_e", "gene_reaction_rule": ""}, {"name": "L-Arginine exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_arg_DASH_L_LPAREN_e_RPAREN_"]}, "metabolites": {"arg__L_e": -1.0}, "id": "EX_arg__L_e", "gene_reaction_rule": ""}, {"name": "L-Ascorbate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_ascb_DASH_L_LPAREN_e_RPAREN_"]}, "metabolites": {"ascb__L_e": -1.0}, "id": "EX_ascb__L_e", "gene_reaction_rule": ""}, {"name": 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"Fe(III)hydroxamate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_fe3hox_LPAREN_e_RPAREN_"]}, "metabolites": {"fe3hox_e": -1.0}, "id": "EX_fe3hox_e", "gene_reaction_rule": ""}, {"name": "Fe(III)hydoxamate, unloaded exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_fe3hox_DASH_un_LPAREN_e_RPAREN_"]}, "metabolites": {"fe3hox_un_e": -1.0}, "id": "EX_fe3hox_un_e", "gene_reaction_rule": ""}, {"name": "Ferrichrome exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_fecrm_LPAREN_e_RPAREN_"]}, "metabolites": {"fecrm_e": -1.0}, "id": "EX_fecrm_e", "gene_reaction_rule": ""}, {"name": "Ferrichrome minus Fe(III) exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_fecrm_DASH_un_LPAREN_e_RPAREN_"]}, "metabolites": {"fecrm_un_e": -1.0}, "id": "EX_fecrm_un_e", "gene_reaction_rule": ""}, {"name": "Fe-enterobactin exchange", "upper_bound": 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["EX_lcts_LPAREN_e_RPAREN_"]}, "metabolites": {"lcts_e": -1.0}, "id": "EX_lcts_e", "gene_reaction_rule": ""}, {"name": "L-Leucine exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_leu_DASH_L_LPAREN_e_RPAREN_"]}, "metabolites": {"leu__L_e": -1.0}, "id": "EX_leu__L_e", "gene_reaction_rule": ""}, {"name": "KDO(2)-lipid (A) exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_lipa_LPAREN_e_RPAREN_"]}, "metabolites": {"lipa_e": -1.0}, "id": "EX_lipa_e", "gene_reaction_rule": ""}, {"name": "Cold adapted KDO(2)-lipid (A) exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_lipa_cold_LPAREN_e_RPAREN_"]}, "metabolites": {"lipa_cold_e": -1.0}, "id": "EX_lipa_cold_e", "gene_reaction_rule": ""}, {"name": "Lipoate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_lipoate_LPAREN_e_RPAREN_"]}, "metabolites": {"lipoate_e": -1.0}, "id": 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"notes": {"original_bigg_ids": ["23CUMPtex"]}, "metabolites": {"23cump_p": 1.0, "23cump_e": -1.0}, "id": "23CUMPtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Transport, Inner Membrane", "name": "2,3-diaminopropionate transport in via proton symport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["23DAPPAt2pp"]}, "metabolites": {"h_p": -1.0, "23dappa_p": -1.0, "23dappa_c": 1.0, "h_c": 1.0}, "id": "23DAPPAt2pp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "2,3-diaminopropionate transport via diffusion", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["23DAPPAtex"]}, "metabolites": {"23dappa_e": -1.0, "23dappa_p": 1.0}, "id": "23DAPPAtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "2',3'-cyclic-nucleotide phosphodiesterase (UMP) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["23PDE2pp"]}, "metabolites": {"h2o_p": -1.0, "23cump_p": -1.0, "3ump_p": 1.0, "h_p": 1.0}, "id": "23PDE2pp", "gene_reaction_rule": "cpdB"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "2',3'-cyclic-nucleotide phosphodiesterase (CMP) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["23PDE4pp"]}, "metabolites": {"h2o_p": -1.0, "3cmp_p": 1.0, "23ccmp_p": -1.0, "h_p": 1.0}, "id": "23PDE4pp", "gene_reaction_rule": "cpdB"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "2',3'-cyclic-nucleotide phosphodiesterase (AMP) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["23PDE7pp"]}, "metabolites": {"3amp_p": 1.0, "h2o_p": -1.0, "h_p": 1.0, "23camp_p": -1.0}, "id": "23PDE7pp", "gene_reaction_rule": "cpdB"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "2',3'-cyclic-nucleotide phosphodiesterase (GMP) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["23PDE9pp"]}, "metabolites": {"h2o_p": -1.0, "3gmp_p": 1.0, "h_p": 1.0, "23cgmp_p": -1.0}, "id": "23PDE9pp", "gene_reaction_rule": "cpdB"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Meso-2,6-Diaminoheptanedioate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["26DAHtex"]}, "metabolites": {"26dap__M_e": -1.0, "26dap__M_p": 1.0}, "id": "26DAHtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphatidate (n-C12:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPA120tipp"]}, "metabolites": {"2ddecg3p_c": 1.0, "2ddecg3p_p": -1.0}, "id": "2AGPA120tipp", "gene_reaction_rule": "c3430"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphatidate (n-C14:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPA140tipp"]}, "metabolites": {"2tdecg3p_c": 1.0, "2tdecg3p_p": -1.0}, "id": "2AGPA140tipp", "gene_reaction_rule": "c3430"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphatidate (n-C14:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPA141tipp"]}, "metabolites": {"2tdec7eg3p_p": -1.0, "2tdec7eg3p_c": 1.0}, "id": "2AGPA141tipp", "gene_reaction_rule": "c3430"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphatidate (n-C16:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPA160tipp"]}, "metabolites": {"2hdecg3p_c": 1.0, "2hdecg3p_p": -1.0}, "id": "2AGPA160tipp", "gene_reaction_rule": "c3430"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphatidate (n-C16:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPA161tipp"]}, "metabolites": {"2hdec9eg3p_c": 1.0, "2hdec9eg3p_p": -1.0}, "id": "2AGPA161tipp", "gene_reaction_rule": "c3430"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphatidate (n-C18:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPA180tipp"]}, "metabolites": {"2odecg3p_p": -1.0, "2odecg3p_c": 1.0}, "id": "2AGPA180tipp", "gene_reaction_rule": "c3430"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphatidate (n-C18:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPA181tipp"]}, "metabolites": {"2odec11eg3p_p": -1.0, "2odec11eg3p_c": 1.0}, "id": "2AGPA181tipp", "gene_reaction_rule": "c3430"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C12:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPE120tipp"]}, "metabolites": {"2agpe120_p": -1.0, "2agpe120_c": 1.0}, "id": "2AGPE120tipp", "gene_reaction_rule": "c3430"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C14:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPE140tipp"]}, "metabolites": {"2agpe140_c": 1.0, "2agpe140_p": -1.0}, "id": "2AGPE140tipp", "gene_reaction_rule": "c3430"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C14:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPE141tipp"]}, 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"lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPE180tipp"]}, "metabolites": {"2agpe180_c": 1.0, "2agpe180_p": -1.0}, "id": "2AGPE180tipp", "gene_reaction_rule": "c3430"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoethanolamine (n-C18:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPE181tipp"]}, "metabolites": {"2agpe181_c": 1.0, "2agpe181_p": -1.0}, "id": "2AGPE181tipp", "gene_reaction_rule": "c3430"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-ethanolamine acyltransferase (n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPEAT120"]}, "metabolites": {"pe120_c": 1.0, "atp_c": -1.0, "ddca_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "2agpe120_c": -1.0}, "id": "2AGPEAT120", "gene_reaction_rule": "c3431"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-ethanolamine acyltransferase (n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPEAT140"]}, "metabolites": {"atp_c": -1.0, "pe140_c": 1.0, "ppi_c": 1.0, "2agpe140_c": -1.0, "amp_c": 1.0, "ttdca_c": -1.0}, "id": "2AGPEAT140", "gene_reaction_rule": "c3431"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-ethanolamine acyltransferase (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPEAT141"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "ttdcea_c": -1.0, "pe141_c": 1.0, "2agpe141_c": -1.0}, "id": "2AGPEAT141", "gene_reaction_rule": "c3431"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-ethanolamine acyltransferase (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPEAT160"]}, "metabolites": {"2agpe160_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "hdca_c": 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(n-C14:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPG141tipp"]}, "metabolites": {"2agpg141_p": -1.0, "2agpg141_c": 1.0}, "id": "2AGPG141tipp", "gene_reaction_rule": "c3430"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPG160tipp"]}, "metabolites": {"2agpg160_c": 1.0, "2agpg160_p": -1.0}, "id": "2AGPG160tipp", "gene_reaction_rule": "c3430"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPG161tipp"]}, "metabolites": {"2agpg161_c": 1.0, "2agpg161_p": -1.0}, "id": "2AGPG161tipp", "gene_reaction_rule": "c3430"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:0) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPG180tipp"]}, "metabolites": {"2agpg180_p": -1.0, "2agpg180_c": 1.0}, "id": "2AGPG180tipp", "gene_reaction_rule": "c3430"}, {"subsystem": "Transport, Inner Membrane", "name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:1) transporter via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPG181tipp"]}, "metabolites": {"2agpg181_p": -1.0, "2agpg181_c": 1.0}, "id": "2AGPG181tipp", "gene_reaction_rule": "c3430"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-glycerol acyltransferase (n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPGAT120"]}, "metabolites": {"atp_c": -1.0, "ddca_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "pg120_c": 1.0, "2agpg120_c": -1.0}, 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["2AGPGAT160"]}, "metabolites": {"2agpg160_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "pg160_c": 1.0, "hdca_c": -1.0}, "id": "2AGPGAT160", "gene_reaction_rule": "c3431"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-glycerol acyltransferase (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPGAT161"]}, "metabolites": {"atp_c": -1.0, "2agpg161_c": -1.0, "ppi_c": 1.0, "hdcea_c": -1.0, "pg161_c": 1.0, "amp_c": 1.0}, "id": "2AGPGAT161", "gene_reaction_rule": "c3431"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "2-acyl-glycerophospho-glycerol acyltransferase (n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["2AGPGAT180"]}, "metabolites": {"pg180_c": 1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "ocdca_c": -1.0, "2agpg180_c": -1.0}, "id": "2AGPGAT180", "gene_reaction_rule": "c3431"}, {"subsystem": "Glycerophospholipid Metabolism", "name": 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Membrane Porin", "name": "3UMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["3UMPtex"]}, "metabolites": {"3ump_e": -1.0, "3ump_p": 1.0}, "id": "3UMPtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "4-hydroxyphenylacetaldehyde transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["4HOXPACDtex"]}, "metabolites": {"4hoxpacd_p": 1.0, "4hoxpacd_e": -1.0}, "id": "4HOXPACDtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "4-Hydroxy-L-threonine synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["4HTHRS"]}, "metabolites": {"phthr_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0, "4hthr_c": 1.0}, "id": "4HTHRS", "gene_reaction_rule": "c0005"}, 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["5DGLCNt2rpp"]}, "metabolites": {"5dglcn_p": -1.0, "5dglcn_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "5DGLCNt2rpp", "gene_reaction_rule": "c5366"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "5-Dehydro-D-gluconate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["5DGLCNtex"]}, "metabolites": {"5dglcn_p": 1.0, "5dglcn_e": -1.0}, "id": "5DGLCNtex", "gene_reaction_rule": "c0388 or c1071 or c2758 or c1822"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "5'-deoxyadenosine nuclosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["5DOAN"]}, "metabolites": {"h2o_c": -1.0, "ade_c": 1.0, "dad_5_c": -1.0, "5drib_c": 1.0}, "id": "5DOAN", "gene_reaction_rule": "c0195"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "5-Methylthio-D-ribose transport via proton diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["5MTRtex"]}, "metabolites": {"5mtr_e": -1.0, "5mtr_p": 1.0}, "id": "5MTRtex", "gene_reaction_rule": "c1822 or c1071 or c2758 or c0388"}, {"subsystem": "Transport, Inner Membrane", "name": "5-Methylthio-D-ribose transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["5MTRtpp"]}, "metabolites": {"5mtr_c": -1.0, "h_c": -1.0, "h_p": 1.0, "5mtr_p": 1.0}, "id": "5MTRtpp", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Arabinose-5-phosphate isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["A5PISO"]}, "metabolites": {"ara5p_c": 1.0, "ru5p__D_c": -1.0}, "id": "A5PISO", "gene_reaction_rule": "c3957 or c3262"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Acyl-[acyl-carrier-protein] synthetase (n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AACPS1"]}, "metabolites": 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"N-acetyl-D-galactosamine 1-phosphatase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGAL1PPpp"]}, "metabolites": {"pi_p": 1.0, "h2o_p": -1.0, "acgal_p": 1.0, "acgal1p_p": -1.0}, "id": "ACGAL1PPpp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "N-acetyl-D-galactosamine 1-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACGAL1Ptex"]}, "metabolites": {"acgal1p_p": 1.0, "acgal1p_e": -1.0}, "id": "ACGAL1Ptex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "N-acetyl-D-galactosamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACGALtex"]}, "metabolites": {"acgal_p": 1.0, "acgal_e": -1.0}, "id": "ACGALtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or 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"c1394"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylglucosamine:undecaprenylphosphate N-acetylglucosamine -1-phosphate transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGAMT"]}, "metabolites": {"uacgam_c": -1.0, "ump_c": 1.0, "unaga_c": 1.0, "udcpp_c": -1.0}, "id": "ACGAMT", "gene_reaction_rule": "c4704"}, {"subsystem": "Transport, Inner Membrane", "name": "N-Acetyl-D-glucosamine transport via PEP:Pyr PTS  (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGAptspp"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "acgam_p": -1.0, "acgam6p_c": 1.0}, "id": "ACGAptspp", "gene_reaction_rule": "(c2952 and c1373 and c2950 and c2951) or (c0755 and c2950 and c2951)"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "N-Acetyl-D-glucosamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ACGAtex"]}, "metabolites": {"acgam_p": 1.0, "acgam_e": -1.0}, "id": "ACGAtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Acetylglutamate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGK"]}, "metabolites": {"acg5p_c": 1.0, "acglu_c": -1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "ACGK", "gene_reaction_rule": "c4918"}, {"subsystem": "Arginine and Proline Metabolism", "name": "N-acetylglutamate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACGS"]}, "metabolites": {"glu__L_c": -1.0, "acglu_c": 1.0, "coa_c": 1.0, "h_c": 1.0, "accoa_c": -1.0}, "id": "ACGS", "gene_reaction_rule": "c3412"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "2-aceto-2-hydroxybutanoate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ACHBS"]}, "metabolites": {"2ahbut_c": 1.0, "2obut_c": -1.0, "pyr_c": 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"1hdec9eg3p_c": -1.0, "ACP_c": 1.0, "hdeACP_c": -1.0}, "id": "AGPAT161", "gene_reaction_rule": "c3758"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-octadecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT180"]}, "metabolites": {"ocdcaACP_c": -1.0, "ACP_c": 1.0, "1odecg3p_c": -1.0, "pa180_c": 1.0}, "id": "AGPAT180", "gene_reaction_rule": "c3758"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "1-octadec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGPAT181"]}, "metabolites": {"1odec11eg3p_c": -1.0, "octeACP_c": -1.0, "ACP_c": 1.0, "pa181_c": 1.0}, "id": "AGPAT181", "gene_reaction_rule": "c3758"}, {"subsystem": "Arginine and Proline Metabolism", "name": "N-acetyl-g-glutamyl-phosphate reductase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AGPR"]}, "metabolites": {"nadp_c": -1.0, "nadph_c": 1.0, "acg5p_c": 1.0, "acg5sa_c": -1.0, "h_c": 1.0, "pi_c": -1.0}, "id": "AGPR", "gene_reaction_rule": "c4917"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Silver transport out via proton antiport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AGt3"]}, "metabolites": {"ag_e": 1.0, "h_e": -1.0, "h_c": 1.0, "ag_c": -1.0}, "id": "AGt3", "gene_reaction_rule": "c0658 and c0659 and c0660 and c0661"}, {"subsystem": "Methionine Metabolism", "name": "S-adenosylhomocysteine nucleosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AHCYSNS"]}, "metabolites": {"ade_c": 1.0, "h2o_c": -1.0, "ahcys_c": -1.0, "rhcys_c": 1.0}, "id": "AHCYSNS", "gene_reaction_rule": "c0195"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylaminoimidazolecarboxamide formyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AICART"]}, "metabolites": {"aicar_c": -1.0, "fprica_c": 1.0, "10fthf_c": -1.0, "thf_c": 1.0}, "id": "AICART", "gene_reaction_rule": "c4964"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylaminoimidazole carboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AIRC2"]}, "metabolites": {"5caiz_c": 1.0, "atp_c": -1.0, "hco3_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "air_c": -1.0, "pi_c": 1.0}, "id": "AIRC2", "gene_reaction_rule": "c0636"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylaminoimidazole carboxylase (mutase rxn)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AIRC3"]}, "metabolites": {"5caiz_c": 1.0, "5aizc_c": -1.0}, "id": "AIRC3", "gene_reaction_rule": "c0637"}, {"subsystem": "Citric Acid Cycle", "name": "2-Oxogluterate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AKGDH"]}, "metabolites": {"akg_c": -1.0, "nadh_c": 1.0, "succoa_c": 1.0, "coa_c": -1.0, "nad_c": -1.0, "co2_c": 1.0}, "id": "AKGDH", "gene_reaction_rule": "c0145 and c0803 and c0804"}, {"subsystem": "Transport, Inner Membrane", "name": "2-oxoglutarate reversible transport via symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AKGt2rpp"]}, "metabolites": {"akg_c": 1.0, "akg_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "AKGt2rpp", "gene_reaction_rule": "c3112"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Alpha-ketoglutarate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AKGtex"]}, "metabolites": {"akg_p": 1.0, "akg_e": -1.0}, "id": "AKGtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Transport, Inner Membrane", "name": "D-alanyl-D-alanine (DalaDala) transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAALAabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "alaala_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "alaala_c": 1.0}, "id": "ALAALAabcpp", "gene_reaction_rule": "c4361 and c4358 and c4357 and c4356 and c4355"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "D-alanine-D-alanine ligase (reversible)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAALAr"]}, "metabolites": {"atp_c": -1.0, "ala__D_c": -2.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "alaala_c": 1.0}, "id": "ALAALAr", "gene_reaction_rule": "c0487 or c0110"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-alanyl-D-alanine (DalaDala) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAALAtex"]}, "metabolites": {"alaala_e": -1.0, "alaala_p": 1.0}, "id": "ALAALAtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Murein Recycling", "name": "L-alanyl-gamma-glutamate epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAGLUE"]}, "metabolites": {"LalaDglu_c": -1.0, "LalaLglu_c": 1.0}, "id": "ALAGLUE", "gene_reaction_rule": "c1797"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "Alanine racemase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAR"]}, "metabolites": {"ala__L_c": -1.0, "ala__D_c": 1.0}, "id": "ALAR", "gene_reaction_rule": "c1639 or c5028"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "D-alanine transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALATA_D2"]}, "metabolites": {"pydx5p_c": -1.0, "pyr_c": 1.0, "ala__D_c": -1.0, "pyam5p_c": 1.0}, "id": "ALATA_D2", "gene_reaction_rule": "c3073 or c1003"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "L-alanine transaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALATA_L"]}, "metabolites": {"akg_c": -1.0, "pyr_c": 1.0, "ala__L_c": -1.0, "glu__L_c": 1.0}, "id": "ALATA_L", "gene_reaction_rule": "c2831 or c2916"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Alanine transaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALATA_L2"]}, "metabolites": {"pydx5p_c": -1.0, "pyr_c": 1.0, "ala__L_c": -1.0, "pyam5p_c": 1.0}, "id": "ALATA_L2", "gene_reaction_rule": "c1003 or c3073"}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "ala__L_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "ala__L_p": -1.0}, "id": "ALAabcpp", "gene_reaction_rule": "c4244 and c4245 and c4247 and c4253 and c4246"}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAt2pp", "ALAt2rpp"]}, "metabolites": {"ala__L_c": 1.0, "h_c": 1.0, "h_p": -1.0, "ala__L_p": -1.0}, "id": "ALAt2pp_copy1", "gene_reaction_rule": "c5307"}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAt2pp", "ALAt2rpp"]}, "metabolites": {"ala__L_c": 1.0, "h_c": 1.0, "h_p": -1.0, "ala__L_p": -1.0}, "id": "ALAt2pp_copy2", "gene_reaction_rule": ""}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanine transport in via sodium symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALAt4pp"]}, "metabolites": {"na1_p": -1.0, "na1_c": 1.0, "ala__L_c": 1.0, "ala__L_p": -1.0}, "id": "ALAt4pp", "gene_reaction_rule": "c0011"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-alanine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALAtex"]}, "metabolites": {"ala__L_e": -1.0, "ala__L_p": 1.0}, "id": "ALAtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Alcohol dehydrogenase (glycerol)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALCD19"]}, "metabolites": {"glyald_c": -1.0, "nadh_c": -1.0, "glyc_c": 1.0, "nad_c": 1.0, "h_c": -1.0}, "id": "ALCD19", "gene_reaction_rule": "c0465"}, {"subsystem": "Pyruvate Metabolism", "name": "Alcohol dehydrogenase (ethanol)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALCD2x"]}, "metabolites": {"acald_c": 1.0, "nadh_c": 1.0, "etoh_c": -1.0, "nad_c": -1.0, "h_c": 1.0}, "id": "ALCD2x", "gene_reaction_rule": "c1911 or c1705 or c0465"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Aldehyde dehydrogenase (acetaldehyde, NADP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALDD2y"]}, "metabolites": {"h2o_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "acald_c": -1.0, "h_c": 2.0, "ac_c": 1.0}, "id": "ALDD2y", "gene_reaction_rule": "c4408"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Aldehyde dehydrogenase (propanal, NADP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALDD3y"]}, "metabolites": {"h2o_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "ppa_c": 1.0, "ppal_c": -1.0, "h_c": 2.0}, "id": "ALDD3y", "gene_reaction_rule": "c4408"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Aldehyde dehydrogenase (butanal, NAD)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALDD4"]}, "metabolites": {"h2o_c": -1.0, "btal_c": -1.0, "but_c": 1.0, "h_c": 2.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "ALDD4", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Allose kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALLK"]}, "metabolites": {"all6p_c": 1.0, "all__D_c": -1.0, "atp_c": -1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "ALLK", "gene_reaction_rule": "c5090"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Allose 6-phosphate isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALLPI"]}, "metabolites": {"all6p_c": -1.0, "allul6p_c": 1.0}, "id": "ALLPI", "gene_reaction_rule": "c5096"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Allantoate amidohydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALLTAMH"]}, "metabolites": {"alltt_c": -1.0, "urdglyc_c": 1.0, "h2o_c": -2.0, "h_c": -2.0, "co2_c": 1.0, "nh4_c": 2.0}, "id": "ALLTAMH", "gene_reaction_rule": "c0630"}, {"subsystem": "Nitrogen Metabolism", "name": "Allantoinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALLTN"]}, "metabolites": {"alltt_c": 1.0, "h2o_c": -1.0, "h_c": 1.0, "alltn_c": -1.0}, "id": "ALLTN", "gene_reaction_rule": "c0626"}, {"subsystem": "Transport, Inner Membrane", "name": "Allantoin transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALLTNt2rpp"]}, "metabolites": {"h_p": -1.0, "alltn_p": -1.0, "alltn_c": 1.0, "h_c": 1.0}, "id": "ALLTNt2rpp", "gene_reaction_rule": "c0625"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Allantoin transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALLTNtex"]}, "metabolites": {"alltn_e": -1.0, "alltn_p": 1.0}, "id": "ALLTNtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Allulose 6-phosphate epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALLULPE"]}, "metabolites": {"allul6p_c": -1.0, "f6p_c": 1.0}, "id": "ALLULPE", "gene_reaction_rule": "c5091"}, {"subsystem": "Transport, Inner Membrane", "name": "D-allose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALLabcpp"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "atp_c": -1.0, "all__D_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "all__D_c": 1.0}, "id": "ALLabcpp", "gene_reaction_rule": "c5093 and c5094 and c5092"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Allose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ALLtex"]}, "metabolites": {"all__D_p": 1.0, "all__D_e": -1.0}, "id": "ALLtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Unassigned", "name": "Apolipoprotein N-acyltransferase (phosphatidylethanolamine, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALPATE160pp"]}, "metabolites": {"alpp_p": -1.0, "lpp_p": 1.0, "2agpe160_p": 1.0, "pe160_p": -1.0}, "id": "ALPATE160pp", "gene_reaction_rule": "c0742 and c2072"}, {"subsystem": "Unassigned", "name": "Apolipoprotein N-acyltransferase (phosphatidylglycerol, periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALPATG160pp"]}, "metabolites": {"alpp_p": -1.0, "pg160_p": -1.0, "2agpg160_p": 1.0, "lpp_p": 1.0}, "id": "ALPATG160pp", "gene_reaction_rule": "c0742 and c2072"}, {"subsystem": "Methylglyoxal Metabolism", "name": "Aldose reductase (methylglyoxal)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALR2"]}, "metabolites": {"acetol_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "mthgxl_c": -1.0}, "id": "ALR2", "gene_reaction_rule": "c3746 or c0244 or c2186 or c3737"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Aldose reductase (acetol)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALR4x"]}, "metabolites": {"nadh_c": -1.0, "acetol_c": -1.0, "12ppd__R_c": 1.0, "nad_c": 1.0, "h_c": -1.0}, "id": "ALR4x", "gene_reaction_rule": "c4904"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Altronate hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ALTRH"]}, "metabolites": {"h2o_c": 1.0, "2ddglcn_c": 1.0, "altrn_c": -1.0}, "id": "ALTRH", "gene_reaction_rule": "c3849"}, {"subsystem": "Murein Recycling", "name": "Anhydrous-N-Acetylmuramyl-tripeptide amidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AM3PA"]}, "metabolites": {"anhm_c": 1.0, "h2o_c": -1.0, "LalaDgluMdap_c": 1.0, "anhm3p_c": -1.0}, "id": "AM3PA", "gene_reaction_rule": "c0129"}, {"subsystem": "Murein Recycling", "name": "Anhydrous-N-Acetylmuramyl-tetrapeptide amidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AM4PA"]}, "metabolites": {"anhm_c": 1.0, "anhm4p_c": -1.0, "LalaDgluMdapDala_c": 1.0, "h2o_c": -1.0}, "id": "AM4PA", "gene_reaction_rule": "c0129"}, {"subsystem": "Murein Recycling", "name": "Anhydrous-N-Acetylmuramyl-tetrapeptide L,D-carboxypeptidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AM4PCP"]}, "metabolites": {"anhm4p_c": -1.0, "ala__D_c": 1.0, "h2o_c": -1.0, "anhm3p_c": 1.0}, "id": "AM4PCP", "gene_reaction_rule": "c1641"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Amylomaltase (maltotriose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMALT1"]}, "metabolites": {"glc__D_c": 1.0, "malt_c": -1.0, "malttr_c": -1.0, "maltttr_c": 1.0}, "id": "AMALT1", "gene_reaction_rule": "c4193"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Amylomaltase (maltotetraose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMALT2"]}, "metabolites": {"maltpt_c": 1.0, "glc__D_c": 1.0, "malt_c": -1.0, "maltttr_c": -1.0}, "id": "AMALT2", "gene_reaction_rule": "c4193"}, {"subsystem": "Alternate Carbon 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"4-amino-2-methyl-5-phosphomethylpyrimidine synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMPMS2"]}, "metabolites": {"h2o_c": -1.0, "nad_c": -1.0, "4ampm_c": 1.0, "h_c": 3.0, "for_c": 2.0, "air_c": -1.0, "nadh_c": 1.0}, "id": "AMPMS2", "gene_reaction_rule": "c4951"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "AMP nucleosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMPN"]}, "metabolites": {"r5p_c": 1.0, "ade_c": 1.0, "h2o_c": -1.0, "amp_c": -1.0}, "id": "AMPN", "gene_reaction_rule": "c2444"}, {"subsystem": "Cysteine Metabolism", "name": "Alanyl aminopeptidase (cys-gly)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMPTASECG"]}, "metabolites": {"cys__L_c": 1.0, "h2o_c": -1.0, "gly_c": 1.0, "cgly_c": -1.0}, "id": "AMPTASECG", "gene_reaction_rule": "c0383 or c1075 or c5360 or c3048"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Aminopeptidase (pro-gly)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["AMPTASEPG"]}, "metabolites": {"h2o_c": -1.0, "pro__L_c": 1.0, "gly_c": 1.0, "progly_c": -1.0}, "id": "AMPTASEPG", "gene_reaction_rule": "c5360 or c0383 or c3048 or c1075"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "AMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AMPtex"]}, "metabolites": {"amp_e": -1.0, "amp_p": 1.0}, "id": "AMPtex", "gene_reaction_rule": "c2758 or c1071 or c1822 or c0388"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "GlcNAc-anhMurNAc transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ANHGMtex"]}, "metabolites": {"anhgm_e": -1.0, "anhgm_p": 1.0}, "id": "ANHGMtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Murein Recycling", "name": "1,6-anhydrous-N-Acetylmuramate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ANHMK"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "anhm_c": -1.0, "acmum6p_c": 1.0}, "id": "ANHMK", "gene_reaction_rule": "c2032"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Anthranilate phosphoribosyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ANPRT"]}, "metabolites": {"anth_c": -1.0, "ppi_c": 1.0, "prpp_c": -1.0, "pran_c": 1.0}, "id": "ANPRT", "gene_reaction_rule": "c1729"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Anthranilate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ANS"]}, "metabolites": {"anth_c": 1.0, "glu__L_c": 1.0, "chor_c": -1.0, "h_c": 1.0, "pyr_c": 1.0, "gln__L_c": -1.0}, "id": "ANS", "gene_reaction_rule": "c1729 and c1730"}, {"subsystem": "Threonine and Lysine 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["APG3PAT120"]}, "metabolites": {"1ddecg3p_c": 1.0, "glyc3p_c": -1.0, "pi_c": 1.0, "h_c": 1.0, "ddcap_c": -1.0}, "id": "APG3PAT120", "gene_reaction_rule": "c3809"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Acyl-phosphate:glycerol-3-phosphate acyltransferase (C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["APG3PAT140"]}, "metabolites": {"1tdecg3p_c": 1.0, "glyc3p_c": -1.0, "pi_c": 1.0, "h_c": 1.0, "ttdcap_c": -1.0}, "id": "APG3PAT140", "gene_reaction_rule": "c3809"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Acyl-phosphate:glycerol-3-phosphate acyltransferase (C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["APG3PAT141"]}, "metabolites": {"ttdceap_c": -1.0, "glyc3p_c": -1.0, "pi_c": 1.0, "h_c": 1.0, "1tdec7eg3p_c": 1.0}, "id": "APG3PAT141", "gene_reaction_rule": "c3809"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Acyl-phosphate:glycerol-3-phosphate acyltransferase (C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["APG3PAT160"]}, "metabolites": {"h_c": 1.0, "glyc3p_c": -1.0, "pi_c": 1.0, "1hdecg3p_c": 1.0, "hdcap_c": -1.0}, "id": "APG3PAT160", "gene_reaction_rule": "c3809"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Acyl-phosphate:glycerol-3-phosphate acyltransferase (C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["APG3PAT161"]}, "metabolites": {"hdceap_c": -1.0, "glyc3p_c": -1.0, "pi_c": 1.0, "h_c": 1.0, "1hdec9eg3p_c": 1.0}, "id": "APG3PAT161", "gene_reaction_rule": "c3809"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Acyl-phosphate:glycerol-3-phosphate acyltransferase (C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["APG3PAT180"]}, "metabolites": {"glyc3p_c": -1.0, "pi_c": 1.0, "ocdcap_c": -1.0, "h_c": 1.0, "1odecg3p_c": 1.0}, "id": "APG3PAT180", "gene_reaction_rule": "c3809"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Acyl-phosphate:glycerol-3-phosphate acyltransferase (C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["APG3PAT181"]}, "metabolites": {"1odec11eg3p_c": 1.0, "glyc3p_c": -1.0, "pi_c": 1.0, "h_c": 1.0, "ocdceap_c": -1.0}, "id": "APG3PAT181", "gene_reaction_rule": "c3809"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Acylphosphatase (C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["APH120"]}, "metabolites": {"ddca_c": 1.0, "ddcap_c": -1.0, "h2o_c": -1.0, "pi_c": 1.0, "h_c": 2.0}, "id": "APH120", "gene_reaction_rule": "c1106"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Acylphosphatase (C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["APH140"]}, "metabolites": {"h2o_c": -1.0, "ttdcap_c": -1.0, "ttdca_c": 1.0, "pi_c": 1.0, "h_c": 2.0}, "id": "APH140", "gene_reaction_rule": "c1106"}, {"subsystem": "Glycerophospholipid 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["CHLtex"]}, "metabolites": {"chol_p": 1.0, "chol_e": -1.0}, "id": "CHLtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Unassigned", "name": "Choline dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHOLD"]}, "metabolites": {"chol_c": -1.0, "nadh_c": 1.0, "betald_c": 1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "CHOLD", "gene_reaction_rule": "c0431"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Chorismate mutase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHORM"]}, "metabolites": {"chor_c": -1.0, "pphn_c": 1.0}, "id": "CHORM", "gene_reaction_rule": "c3120 or c3121"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Chorismate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHORS"]}, "metabolites": {"chor_c": 1.0, "pi_c": 1.0, "3psme_c": -1.0}, "id": "CHORS", "gene_reaction_rule": "c2875"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Chorismate pyruvate lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHRPL"]}, "metabolites": {"4hbz_c": 1.0, "chor_c": -1.0, "pyr_c": 1.0}, "id": "CHRPL", "gene_reaction_rule": "c5009"}, {"subsystem": "Transport, Inner Membrane", "name": "Chitobiose transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHTBSptspp"]}, "metabolites": {"chtbs_p": -1.0, "pep_c": -1.0, "pyr_c": 1.0, "chtbs6p_c": 1.0}, "id": "CHTBSptspp", "gene_reaction_rule": "c2951"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Chitobiose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CHTBStex"]}, "metabolites": {"chtbs_p": 1.0, "chtbs_e": -1.0}, "id": "CHTBStex", "gene_reaction_rule": "c2758 or c1071 or c1822 or c0388"}, {"subsystem": "Citric Acid Cycle", "name": "Citrate lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CITL"]}, "metabolites": {"ac_c": 1.0, "oaa_c": 1.0, "cit_c": -1.0}, "id": "CITL", "gene_reaction_rule": "(c0704 and c0706 and citD) and c0702"}, {"subsystem": "Transport, Inner Membrane", "name": "Citrate transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CITt3pp"]}, "metabolites": {"cit_p": 1.0, "h_c": 1.0, "h_p": -1.0, "cit_c": -1.0}, "id": "CITt3pp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Inner Membrane", "name": "Citrate transport via succinate antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CITt7pp"]}, "metabolites": {"succ_p": 1.0, "succ_c": -1.0, "cit_p": -1.0, "cit_c": 1.0}, "id": "CITt7pp", "gene_reaction_rule": "c0700"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Citrate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CITtex"]}, "metabolites": {"cit_e": -1.0, "cit_p": 1.0}, "id": "CITtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Cold lipid A transport via ABC system (periplasm to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLIPAabctex"]}, "metabolites": {"lipa_cold_e": 1.0, "atp_c": -1.0, "h2o_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "lipa_cold_p": -1.0, "pi_c": 1.0}, "id": "CLIPAabctex", "gene_reaction_rule": "c3960 and c3961 and c3959 and c5362 and c5363"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C12:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH120pp"]}, "metabolites": {"h2o_p": -1.0, "pg120_p": 1.0, "pa120_p": 1.0, "h_p": 1.0, "clpn120_p": -1.0}, "id": "CLPNH120pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH140pp"]}, "metabolites": {"pa140_p": 1.0, "h2o_p": -1.0, "pg140_p": 1.0, "clpn140_p": -1.0, "h_p": 1.0}, "id": "CLPNH140pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH141pp"]}, "metabolites": {"pa141_p": 1.0, "pg141_p": 1.0, "clpn141_p": -1.0, "h_p": 1.0, "h2o_p": -1.0}, "id": "CLPNH141pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH160pp"]}, "metabolites": {"pg160_p": 1.0, "h2o_p": -1.0, "clpn160_p": -1.0, "pa160_p": 1.0, "h_p": 1.0}, "id": "CLPNH160pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH161pp"]}, "metabolites": {"pa161_p": 1.0, "h2o_p": -1.0, "clpn161_p": -1.0, "h_p": 1.0, "pg161_p": 1.0}, "id": "CLPNH161pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH180pp"]}, "metabolites": {"clpn180_p": -1.0, "h2o_p": -1.0, "pa180_p": 1.0, "pg180_p": 1.0, "h_p": 1.0}, "id": "CLPNH180pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin hydrolase (periplasm, n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLPNH181pp"]}, "metabolites": {"h2o_p": -1.0, "pg181_p": 1.0, "pa181_p": 1.0, "h_p": 1.0, "clpn181_p": -1.0}, "id": "CLPNH181pp", "gene_reaction_rule": ""}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin synthase (periplasmic, n-C12:0)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CLPNS120pp"]}, "metabolites": {"pg120_p": -2.0, "clpn120_p": 1.0, "glyc_p": 1.0}, "id": "CLPNS120pp", "gene_reaction_rule": "c0872 or c1713"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin synthase (periplasmic, n-C14:0)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CLPNS140pp"]}, "metabolites": {"clpn140_p": 1.0, "pg140_p": -2.0, "glyc_p": 1.0}, "id": "CLPNS140pp", "gene_reaction_rule": "c1713 or c0872"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin synthase (periplasmic, n-C14:1)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CLPNS141pp"]}, "metabolites": {"clpn141_p": 1.0, "pg141_p": -2.0, "glyc_p": 1.0}, "id": "CLPNS141pp", "gene_reaction_rule": "c0872 or c1713"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin synthase (periplasmic, n-C16:0)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CLPNS160pp"]}, "metabolites": {"pg160_p": -2.0, "clpn160_p": 1.0, "glyc_p": 1.0}, "id": "CLPNS160pp", "gene_reaction_rule": "c0872 or c1713"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin synthase (periplasmic, n-C16:1)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CLPNS161pp"]}, "metabolites": {"pg161_p": -2.0, "clpn161_p": 1.0, "glyc_p": 1.0}, "id": "CLPNS161pp", "gene_reaction_rule": "c1713 or c0872"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin synthase (periplasmic, n-C18:0)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CLPNS180pp"]}, "metabolites": {"clpn180_p": 1.0, "pg180_p": -2.0, "glyc_p": 1.0}, "id": "CLPNS180pp", "gene_reaction_rule": "c0872 or c1713"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Cardiolipin synthase (periplasmic, n-C18:1)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CLPNS181pp"]}, "metabolites": {"clpn181_p": 1.0, "glyc_p": 1.0, "pg181_p": -2.0}, "id": "CLPNS181pp", "gene_reaction_rule": "c0872 or c1713"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Chloride transport out via proton antiport (2:1) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CLt3_2pp"]}, "metabolites": {"cl_p": -2.0, "h_c": -1.0, "h_p": 1.0, "cl_c": 2.0}, "id": "CLt3_2pp", "gene_reaction_rule": "c0190 or c1983"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Chloride (Cl-1) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CLtex"]}, "metabolites": {"cl_e": -1.0, "cl_p": 1.0}, "id": "CLtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "CMP nucleosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CMPN"]}, "metabolites": {"h2o_c": -1.0, "csn_c": 1.0, "r5p_c": 1.0, "cmp_c": -1.0}, "id": "CMPN", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "CMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CMPtex"]}, "metabolites": {"cmp_e": -1.0, "cmp_p": 1.0}, "id": "CMPtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Chloramphenicol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CMtex"]}, "metabolites": {"cm_e": -1.0, "cm_p": 1.0}, "id": "CMtex", "gene_reaction_rule": "c1822 or c2758 or c1071 or c0388"}, {"subsystem": "Transport, Outer 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(periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["COBALT2abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "cobalt2_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "cobalt2_p": 1.0}, "id": "COBALT2abcpp", "gene_reaction_rule": "c4262"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Cobalt (Co+2) transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["COBALT2t3pp"]}, "metabolites": {"cobalt2_c": -1.0, "cobalt2_p": 1.0, "h_p": -1.0, "h_c": 1.0}, "id": "COBALT2t3pp", "gene_reaction_rule": "c0827 or c4866"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Cobalt (Co+2) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["COBALT2tex"]}, "metabolites": {"cobalt2_e": -1.0, "cobalt2_p": 1.0}, "id": "COBALT2tex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Cobalt transport in via permease (no H+)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["COBALT2tpp"]}, "metabolites": {"cobalt2_p": -1.0, "cobalt2_c": 1.0}, "id": "COBALT2tpp", "gene_reaction_rule": "c3789 or c4737"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Lipid A core kinase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["COLIPAKpp"]}, "metabolites": {"colipa_p": -1.0, "udcpdp_p": -1.0, "udcpp_p": 1.0, "colipap_p": 1.0}, "id": "COLIPAKpp", "gene_reaction_rule": "c2711"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Core oligosaccharide lipid A diphosphate transport via ABC system (periplasm to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["COLIPAPabctex"]}, "metabolites": {"h2o_c": -1.0, "colipap_e": 1.0, "colipap_p": -1.0, "atp_c": -1.0, "h_c": 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["D_DASH_LACtex"]}, "metabolites": {"lac__D_e": -1.0, "lac__D_p": 1.0}, "id": "D_LACtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "D-Amino acid dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAAD"]}, "metabolites": {"h2o_c": -1.0, "pyr_c": 1.0, "fadh2_c": 1.0, "ala__D_c": -1.0, "nh4_c": 1.0, "fad_c": -1.0}, "id": "DAAD", "gene_reaction_rule": "c1638"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Deoxyadenosine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DADA"]}, "metabolites": {"din_c": 1.0, "dad_2_c": -1.0, "h2o_c": -1.0, "nh4_c": 1.0, "h_c": -1.0}, "id": "DADA", "gene_reaction_rule": "c2015"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Deoxyadenylate kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DADK", "DAMPK"]}, "metabolites": {"dadp_c": 1.0, "damp_c": -1.0, 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{"subsystem": "Transport, Inner Membrane", "name": "D-alanine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DALAt2pp"]}, "metabolites": {"ala__D_c": 1.0, "h_c": 1.0, "h_p": -1.0, "ala__D_p": -1.0}, "id": "DALAt2pp", "gene_reaction_rule": "c5307"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-Alanine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DALAtex"]}, "metabolites": {"ala__D_e": -1.0, "ala__D_p": 1.0}, "id": "DALAtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "DAMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DAMPtex"]}, "metabolites": {"damp_p": 1.0, "damp_e": -1.0}, "id": "DAMPtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2,3-diaminopropionate amonnia lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAPAL"]}, "metabolites": {"h2o_c": -1.0, "pyr_c": 1.0, "nh4_c": 2.0, "23dappa_c": -1.0}, "id": "DAPAL", "gene_reaction_rule": "c3449"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Diaminopimelate decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DAPDC"]}, "metabolites": {"co2_c": 1.0, "lys__L_c": 1.0, "h_c": -1.0, "26dap__M_c": -1.0}, "id": "DAPDC", "gene_reaction_rule": "c3435"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Diaminopimelate epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DAPE"]}, "metabolites": {"26dap_LL_c": -1.0, "26dap__M_c": 1.0}, "id": "DAPE", "gene_reaction_rule": "c4730"}, {"subsystem": "Transport, Inner Membrane", "name": "M-diaminopimelic acid ABC transport (periplasm)", 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"CDP-diacylglycerol synthetase (n-C14:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DASYN140"]}, "metabolites": {"ctp_c": -1.0, "cdpdtdecg_c": 1.0, "ppi_c": 1.0, "pa140_c": -1.0, "h_c": -1.0}, "id": "DASYN140", "gene_reaction_rule": "c0212"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-diacylglycerol synthetase (n-C14:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DASYN141"]}, "metabolites": {"ctp_c": -1.0, "ppi_c": 1.0, "pa141_c": -1.0, "h_c": -1.0, "cdpdtdec7eg_c": 1.0}, "id": "DASYN141", "gene_reaction_rule": "c0212"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-diacylglycerol synthetase (n-C16:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DASYN160"]}, "metabolites": {"ctp_c": -1.0, "pa160_c": -1.0, "ppi_c": 1.0, "cdpdhdecg_c": 1.0, "h_c": -1.0}, "id": "DASYN160", "gene_reaction_rule": "c0212"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-diacylglycerol synthetase (n-C16:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DASYN161"]}, "metabolites": {"pa161_c": -1.0, "ctp_c": -1.0, "ppi_c": 1.0, "cdpdhdec9eg_c": 1.0, "h_c": -1.0}, "id": "DASYN161", "gene_reaction_rule": "c0212"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-diacylglycerol synthetase (n-C18:0)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DASYN180"]}, "metabolites": {"ctp_c": -1.0, "cdpdodecg_c": 1.0, "ppi_c": 1.0, "h_c": -1.0, "pa180_c": -1.0}, "id": "DASYN180", "gene_reaction_rule": "c0212"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "CDP-diacylglycerol synthetase (n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DASYN181"]}, "metabolites": {"ctp_c": -1.0, "ppi_c": 1.0, "cdpdodec11eg_c": 1.0, "pa181_c": -1.0, "h_c": -1.0}, "id": "DASYN181", "gene_reaction_rule": "c0212"}, {"subsystem": "Nucleotide Salvage 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"name": "Diacetylchitobiose-6-phosphate hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DC6PH"]}, "metabolites": {"acgam_c": 1.0, "h2o_c": -1.0, "chtbs6p_c": -1.0, "acgam6p_c": 1.0}, "id": "DC6PH", "gene_reaction_rule": "c2133"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Decanoate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DCAtex"]}, "metabolites": {"dca_e": -1.0, "dca_p": 1.0}, "id": "DCAtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "DCMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DCMPtex"]}, "metabolites": {"dcmp_p": 1.0, "dcmp_e": -1.0}, "id": "DCMPtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "DCTP deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DCTPD"]}, "metabolites": {"h_c": -1.0, "h2o_c": -1.0, "dctp_c": -1.0, "nh4_c": 1.0, "dutp_c": 1.0}, "id": "DCTPD", "gene_reaction_rule": "c2592"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Deoxycytidine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DCYTD"]}, "metabolites": {"dcyt_c": -1.0, "h2o_c": -1.0, "nh4_c": 1.0, "duri_c": 1.0, "h_c": -1.0}, "id": "DCYTD", "gene_reaction_rule": "c2675"}, {"subsystem": "Transport, Inner Membrane", "name": "Deoxycytidine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DCYTt2pp"]}, "metabolites": {"dcyt_c": 1.0, "dcyt_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "DCYTt2pp", "gene_reaction_rule": "c2932 or c3552"}, {"subsystem": "Transport, Outer Membrane", "name": "Deoxycytidine transport via diffusion (extracellular to periplasm)", 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"upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DDGLCNt2rpp"]}, "metabolites": {"2ddglcn_p": -1.0, "2ddglcn_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "DDGLCNt2rpp", "gene_reaction_rule": "c4861"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "2-dehydro-3-deoxy-D-gluconate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DDGLCNtex"]}, "metabolites": {"2ddglcn_p": 1.0, "2ddglcn_e": -1.0}, "id": "DDGLCNtex", "gene_reaction_rule": "c1071 or c1822 or c2758 or c0388"}, {"subsystem": "Alternate Carbon Metabolism", "name": "2-dehydro-3-deoxygluconokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DDGLK"]}, "metabolites": {"h_c": 1.0, "2ddglcn_c": -1.0, "2ddg6p_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "DDGLK", "gene_reaction_rule": "c4337"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DDPA"]}, "metabolites": {"pep_c": -1.0, "e4p_c": -1.0, "pi_c": 1.0, "2dda7p_c": 1.0, "h2o_c": -1.0}, "id": "DDPA", "gene_reaction_rule": "c3122 or c0830 or c2100"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Deoxyguanylate kinase (dGMP:ATP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DGK1"]}, "metabolites": {"dgdp_c": 1.0, "dgmp_c": -1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "DGK1", "gene_reaction_rule": "c4473"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "DGMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DGMPtex"]}, "metabolites": {"dgmp_e": -1.0, "dgmp_p": 1.0}, "id": "DGMPtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Transport, Inner Membrane", "name": "Deoxyguanosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DGSNt2pp"]}, "metabolites": {"dgsn_c": 1.0, "dgsn_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "DGSNt2pp", "gene_reaction_rule": "c3552"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Deoxyguanosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DGSNtex"]}, "metabolites": {"dgsn_p": 1.0, "dgsn_e": -1.0}, "id": "DGSNtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylbutanoate)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHAD1"]}, "metabolites": {"h2o_c": 1.0, "23dhmb_c": -1.0, "3mob_c": 1.0}, "id": "DHAD1", "gene_reaction_rule": "c4693"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Dihydroxy-acid dehydratase (2,3-dihydroxy-3-methylpentanoate)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHAD2"]}, "metabolites": {"23dhmp_c": -1.0, "3mop_c": 1.0, "h2o_c": 1.0}, "id": "DHAD2", "gene_reaction_rule": "c4693"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Dihydroxyacetone phosphotransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHAPT"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "dhap_c": 1.0, "dha_c": -1.0}, "id": "DHAPT", "gene_reaction_rule": "c1658 and c1657 and c1656 and c2950 and c2951"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Dihydroxyacetone transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHAtex"]}, "metabolites": {"dha_e": -1.0, "dha_p": 1.0}, "id": "DHAtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Transport, Inner Membrane", "name": "Dihydroxyacetone transport via facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHAtpp"]}, "metabolites": {"dha_p": -1.0, "dha_c": 1.0}, "id": "DHAtpp", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHBD"]}, "metabolites": {"23dhb_c": 1.0, "nadh_c": 1.0, "23ddhb_c": -1.0, "nad_c": -1.0, "h_c": 1.0}, "id": "DHBD", "gene_reaction_rule": "c0683"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2,3-dihydroxybenzoate adenylate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHBS"]}, "metabolites": {"23dhb_c": -1.0, "23dhba_c": 1.0, "ppi_c": 1.0, "h_c": -1.0, "atp_c": -1.0}, "id": "DHBS", "gene_reaction_rule": "c0681"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2,3-dihydroxybenzoylserine hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHBSH"]}, "metabolites": {"23dhb_c": 1.0, "ser__L_c": 1.0, "h2o_c": -1.0, "23dhbzs_c": -1.0}, "id": "DHBSH", "gene_reaction_rule": ""}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Dihydrodipicolinate reductase (NADPH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHDPRy"]}, "metabolites": {"thdp_c": 1.0, "nadph_c": -1.0, "23dhdp_c": -1.0, "nadp_c": 1.0, "h_c": -1.0}, "id": "DHDPRy", "gene_reaction_rule": "c0037"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Dihydrodipicolinate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHDPS"]}, "metabolites": {"aspsa_c": -1.0, "pyr_c": -1.0, "23dhdp_c": 1.0, "h2o_c": 2.0, "h_c": 1.0}, "id": "DHDPS", "gene_reaction_rule": "c3006"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydrofolate reductase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHFR"]}, "metabolites": {"dhf_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "thf_c": 1.0, "h_c": -1.0}, "id": "DHFR", "gene_reaction_rule": "c1998 or c0058"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydrofolate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHFS"]}, "metabolites": {"dhf_c": 1.0, "atp_c": -1.0, "glu__L_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "dhpt_c": -1.0, "pi_c": 1.0}, "id": "DHFS", "gene_reaction_rule": "c2860"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydromonapterin reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHMPTR"]}, "metabolites": {"nadph_c": -1.0, "thmnp_c": 1.0, "nadp_c": 1.0, "dhmpt_c": -1.0, "h_c": -1.0}, "id": "DHMPTR", "gene_reaction_rule": "c1998"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "1,4-dihydroxy-2-naphthoate octaprenyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHNAOT4"]}, "metabolites": {"co2_c": 1.0, "octdp_c": -1.0, "ppi_c": 1.0, "2dmmql8_c": 1.0, "h_c": -1.0, "dhna_c": -1.0}, "id": "DHNAOT4", "gene_reaction_rule": "c4883"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "1,4-dihydroxy-2-napthoyl-CoA synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHNCOAS"]}, "metabolites": {"sbzcoa_c": -1.0, "h2o_c": 1.0, "h_c": -1.0, "14dhncoa_c": 1.0}, "id": "DHNCOAS", "gene_reaction_rule": "c2805"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "1,4-dihydroxy-2-napthoyl-CoA thioesterase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHNCOAT"]}, "metabolites": {"h2o_c": -1.0, "dhna_c": 1.0, "coa_c": 1.0, "h_c": 1.0, "14dhncoa_c": -1.0}, "id": "DHNCOAT", "gene_reaction_rule": "c0815"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydroneopterin aldolase reversible", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHNPA2r"]}, "metabolites": {"dhnpt_c": -1.0, "6hmhpt_c": 1.0, "gcald_c": 1.0}, "id": "DHNPA2r", "gene_reaction_rule": "c3808"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydroneopterin epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHNPTE"]}, "metabolites": {"dhnpt_c": -1.0, "dhmpt_c": 1.0}, "id": "DHNPTE", "gene_reaction_rule": "c3808"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Dihydoorotic acid dehydrogenase (quinone8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHORD2"]}, "metabolites": {"q8h2_c": 1.0, "dhor__S_c": -1.0, "q8_c": -1.0, "orot_c": 1.0}, "id": "DHORD2", "gene_reaction_rule": "c1081"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Dihydroorotic acid (menaquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHORD5"]}, "metabolites": {"dhor__S_c": -1.0, "mqn8_c": -1.0, "mql8_c": 1.0, "orot_c": 1.0}, "id": "DHORD5", "gene_reaction_rule": "c1081"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Fumarate dependent DHORD", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHORDfum"]}, "metabolites": {"fum_c": -1.0, "succ_c": 1.0, "dhor__S_c": -1.0, "orot_c": 1.0}, "id": "DHORDfum", "gene_reaction_rule": ""}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Dihydroorotase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHORTS"]}, "metabolites": {"cbasp_c": 1.0, "h2o_c": -1.0, "dhor__S_c": -1.0, "h_c": 1.0}, "id": "DHORTS", "gene_reaction_rule": "c1329"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Diaminohydroxyphosphoribosylaminopryrimidine deaminase (25drapp)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPPDA2"]}, "metabolites": {"5apru_c": 1.0, "h2o_c": -1.0, "nh4_c": 1.0, "25drapp_c": -1.0, "h_c": -1.0}, "id": "DHPPDA2", "gene_reaction_rule": "c0524"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydropteroate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPS2"]}, "metabolites": {"dhpt_c": 1.0, "6hmhptpp_c": -1.0, "ppi_c": 1.0, "4abz_c": -1.0}, "id": "DHPS2", "gene_reaction_rule": "c3933"}, {"subsystem": "Methionine Metabolism", "name": "4,5-dihydroxy-2,3-pentanedione cyclization (spontaneous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPTDCs2"]}, "metabolites": {"dhptd_c": -1.0, "mdhdhf_c": 1.0}, "id": "DHPTDCs2", "gene_reaction_rule": "s0001"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Dihydropteridine reductase", "upper_bound": 0.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPTDNR"]}, "metabolites": {"dhptdn_c": -1.0, "thptdn_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -3.0}, "id": "DHPTDNR", "gene_reaction_rule": "c0664"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Dihydropteridine reductase (NADH)", "upper_bound": 0.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHPTDNRN"]}, "metabolites": {"thptdn_c": 1.0, "dhptdn_c": -1.0, "nadh_c": -1.0, "h_c": -3.0, "nad_c": 1.0}, "id": "DHPTDNRN", "gene_reaction_rule": "c0664"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Dihydroneopterin triphosphate 2'-epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DHPTPE"]}, "metabolites": {"dhmptp_c": 1.0, "ahdt_c": -1.0}, "id": "DHPTPE", "gene_reaction_rule": "c2846"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "3-dehydroquinate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHQS"]}, "metabolites": {"3dhq_c": 1.0, "pi_c": 1.0, "2dda7p_c": -1.0}, "id": "DHQS", "gene_reaction_rule": "c4159"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "3-dehydroquinate dehydratase, irreversible", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DHQTi"]}, "metabolites": {"3dhsk_c": 1.0, "h2o_c": 1.0, "3dhq_c": -1.0}, "id": "DHQTi", "gene_reaction_rule": "c2088"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "DIMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DIMPtex"]}, "metabolites": {"dimp_p": 1.0, "dimp_e": -1.0}, "id": "DIMPtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Transport, Inner Membrane", "name": "Deoxyinosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DINSt2pp"]}, "metabolites": {"din_p": -1.0, "din_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "DINSt2pp", 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"ECAP1pp", "gene_reaction_rule": "c4715 and c4705"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Enterobacterial common antigen polymerase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ECAP2pp"]}, "metabolites": {"eca2und_p": -1.0, "unagamuf_p": -1.0, "eca3und_p": 1.0, "udcpdp_p": 1.0, "h_p": 1.0}, "id": "ECAP2pp", "gene_reaction_rule": "c4715 and c4705"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Enterobacterial common antigen polymerase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ECAP3pp"]}, "metabolites": {"eca3und_p": -1.0, "eca4und_p": 1.0, "udcpdp_p": 1.0, "h_p": 1.0, "unagamuf_p": -1.0}, "id": "ECAP3pp", "gene_reaction_rule": "c4715 and c4705"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Enterobacterial common antigen transferase (flippase, cytoplasm to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ECAtpp"]}, "metabolites": {"unagamuf_p": 1.0, "unagamuf_c": -1.0}, "id": "ECAtpp", "gene_reaction_rule": "c4713"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH1"]}, "metabolites": {"b2coa_c": 1.0, "3hbcoa_c": -1.0, "h2o_c": 1.0}, "id": "ECOAH1", "gene_reaction_rule": "c4793 or c2886"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxyhexanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH2"]}, "metabolites": {"3hhcoa_c": -1.0, "h2o_c": 1.0, "hx2coa_c": 1.0}, "id": "ECOAH2", "gene_reaction_rule": "c4793 or c2886"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxyoctanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH3"]}, "metabolites": {"oc2coa_c": 1.0, "h2o_c": 1.0, "3hocoa_c": -1.0}, "id": "ECOAH3", "gene_reaction_rule": "c4793 or c2886"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxydecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH4"]}, "metabolites": {"3hdcoa_c": -1.0, "h2o_c": 1.0, "dc2coa_c": 1.0}, "id": "ECOAH4", "gene_reaction_rule": "c4793 or c2886"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxydodecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH5"]}, "metabolites": {"h2o_c": 1.0, "3hddcoa_c": -1.0, "dd2coa_c": 1.0}, "id": "ECOAH5", "gene_reaction_rule": "c4793 or c2886"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxytetradecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH6"]}, "metabolites": {"h2o_c": 1.0, "3htdcoa_c": -1.0, "td2coa_c": 1.0}, "id": "ECOAH6", "gene_reaction_rule": "c4793 or c2886"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxyhexadecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH7"]}, "metabolites": {"h2o_c": 1.0, "hdd2coa_c": 1.0, "3hhdcoa_c": -1.0}, "id": "ECOAH7", "gene_reaction_rule": "c4793 or c2886"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydratase (3-hydroxyoctadecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ECOAH8"]}, "metabolites": {"3hodcoa_c": -1.0, "od2coa_c": 1.0, "h2o_c": 1.0}, "id": "ECOAH8", "gene_reaction_rule": "c4793 or c2886"}, {"subsystem": "Pentose Phosphate Pathway", "name": "2-dehydro-3-deoxy-phosphogluconate aldolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EDA"]}, "metabolites": {"pyr_c": 1.0, "g3p_c": 1.0, "2ddg6p_c": -1.0}, "id": "EDA", "gene_reaction_rule": "c2263"}, {"subsystem": "Pentose Phosphate Pathway", "name": "6-phosphogluconate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EDD"]}, "metabolites": {"6pgc_c": -1.0, "h2o_c": 1.0, "2ddg6p_c": 1.0}, "id": "EDD", "gene_reaction_rule": "c2264"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Endotoxin Synthesis (lauroyl transferase)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EDTXS1"]}, "metabolites": {"kdo2lipid4_c": -1.0, "kdo2lipid4L_c": 1.0, "ACP_c": 1.0, "ddcaACP_c": -1.0}, "id": "EDTXS1", "gene_reaction_rule": "c1320"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Endotoxin Synthesis (myristoyl transferase)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EDTXS2"]}, "metabolites": {"kdo2lipid4L_c": -1.0, "ACP_c": 1.0, "lipa_c": 1.0, "myrsACP_c": -1.0}, "id": "EDTXS2", "gene_reaction_rule": "c2269"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Endotoxin Synthesis (palmitoleoyl ACP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EDTXS3"]}, "metabolites": {"kdo2lipid4_c": -1.0, "ACP_c": 1.0, "hdeACP_c": -1.0, "kdo2lipid4p_c": 1.0}, "id": "EDTXS3", "gene_reaction_rule": "c2915"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Endotoxin Synthesis (myristoyl transferase)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EDTXS4"]}, "metabolites": {"ACP_c": 1.0, "lipa_cold_c": 1.0, "kdo2lipid4p_c": -1.0, "myrsACP_c": -1.0}, "id": "EDTXS4", "gene_reaction_rule": "c2269"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Enoylglutaryl-[ACP] methyl ester reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EGMEACPR"]}, "metabolites": {"gmeACP_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "egmeACP_c": -1.0}, "id": "EGMEACPR", "gene_reaction_rule": "c1759"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Phosphoethanolamine lipid A transport via ABC system (periplasm to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ENLIPAabctex"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "enlipa_e": 1.0, "h_c": 1.0, "adp_c": 1.0, "enlipa_p": -1.0, "pi_c": 1.0}, "id": "ENLIPAabctex", "gene_reaction_rule": "c3960 and c3961 and c3959 and c5362 and c5363"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Enolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ENO"]}, "metabolites": {"pep_c": 1.0, "h2o_c": 1.0, "2pg_c": -1.0}, "id": "ENO", "gene_reaction_rule": "c3344"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Enterochelin synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ENTCS"]}, "metabolites": {"23dhba_c": -3.0, "seramp_c": -3.0, 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1.0, "nadph_c": -1.0, "h_c": -1.0}, "id": "EPMEACPR", "gene_reaction_rule": "c1759"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Ethanolamine ammonia-lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ETHAAL"]}, "metabolites": {"acald_c": 1.0, "nh4_c": 1.0, "etha_c": -1.0}, "id": "ETHAAL", "gene_reaction_rule": "c2974 and c2975"}, {"subsystem": "Transport, Inner Membrane", "name": "Ethanolamine transport in via proton symport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ETHAt2pp"]}, "metabolites": {"etha_p": -1.0, "etha_c": 1.0, "h_p": -1.0, "h_c": 1.0}, "id": "ETHAt2pp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Ethanolamine transport via diffusion (extracellular)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ETHAtex"]}, "metabolites": {"etha_e": -1.0, "etha_p": 1.0}, "id": "ETHAtex", "gene_reaction_rule": "c0388 or c1071 or c1822 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-1.0, "etoh_p": 1.0}, "id": "ETOHtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Transport, Inner Membrane", "name": "Ethanol reversible transport via diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ETOHtrpp"]}, "metabolites": {"etoh_p": -1.0, "etoh_c": 1.0}, "id": "ETOHtrpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Fructose 6-phosphate aldolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["F6PA"]}, "metabolites": {"g3p_c": 1.0, "dha_c": 1.0, "f6p_c": -1.0}, "id": "F6PA", "gene_reaction_rule": "c0910 or c4905"}, {"subsystem": "Alternate Carbon Metabolism", "name": "D-fructose 6-phosphate phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["F6PP"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "fru_c": 1.0, "f6p_c": -1.0}, "id": "F6PP", "gene_reaction_rule": "c0907"}, {"subsystem": "Transport, Inner Membrane", "name": "Fructose-6-phosphate transport via phosphate antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["F6Pt6_2pp"]}, "metabolites": {"pi_p": 2.0, "pi_c": -2.0, "f6p_p": -1.0, "f6p_c": 1.0}, "id": "F6Pt6_2pp", "gene_reaction_rule": "c4590"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Fructose 6-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["F6Ptex"]}, "metabolites": {"f6p_e": -1.0, "f6p_p": 1.0}, "id": "F6Ptex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Fatty-acyl-ACP hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FA100ACPHi"]}, "metabolites": {"h_c": 1.0, "h2o_c": -1.0, "ACP_c": 1.0, "dcaACP_c": -1.0, "dca_c": 1.0}, "id": "FA100ACPHi", "gene_reaction_rule": "c0514"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Fatty-acyl-ACP hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FA120ACPHi"]}, "metabolites": {"ddca_c": 1.0, "h2o_c": -1.0, "ACP_c": 1.0, "h_c": 1.0, "ddcaACP_c": -1.0}, "id": "FA120ACPHi", "gene_reaction_rule": "c0514"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Fatty-acyl-ACP hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FA140ACPHi"]}, "metabolites": {"h2o_c": -1.0, "ACP_c": 1.0, "ttdca_c": 1.0, "myrsACP_c": -1.0, "h_c": 1.0}, "id": "FA140ACPHi", "gene_reaction_rule": "c0514"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Fatty-acyl-ACP hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FA141ACPHi"]}, "metabolites": {"tdeACP_c": -1.0, "h2o_c": -1.0, "ACP_c": 1.0, "h_c": 1.0, "ttdcea_c": 1.0}, "id": "FA141ACPHi", "gene_reaction_rule": "c0514"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Fatty-acyl-ACP 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"id": "FTHFLi", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-fucose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FUCtex"]}, "metabolites": {"fuc__L_p": 1.0, "fuc__L_e": -1.0}, "id": "FUCtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Transport, Inner Membrane", "name": "L-fucose transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FUCtpp"]}, "metabolites": {"fuc__L_p": -1.0, "fuc__L_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "FUCtpp", "gene_reaction_rule": "c3370"}, {"subsystem": "Citric Acid Cycle", "name": "Fumarase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FUM"]}, "metabolites": {"h2o_c": -1.0, "fum_c": -1.0, "mal__L_c": 1.0}, "id": "FUM", "gene_reaction_rule": "c2004 or c2003"}, {"subsystem": "Transport, Inner 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"c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Galactarate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALCTD"]}, "metabolites": {"h2o_c": 1.0, "5dh4dglc_c": 1.0, "galct__D_c": -1.0}, "id": "GALCTD", "gene_reaction_rule": "c3883"}, {"subsystem": "Alternate Carbon Metabolism", "name": "L-galactonate oxidoreductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALCTLO"]}, "metabolites": {"galctn__L_c": -1.0, "nadh_c": 1.0, "tagur_c": 1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "GALCTLO", "gene_reaction_rule": "c5437"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Galactonate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALCTND"]}, "metabolites": {"galctn__D_c": -1.0, "h2o_c": 1.0, "2dh3dgal_c": 1.0}, "id": "GALCTND", "gene_reaction_rule": "dgoD"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-galactonate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALCTNLtex"]}, "metabolites": {"galctn__L_p": 1.0, "galctn__L_e": -1.0}, "id": "GALCTNLtex", "gene_reaction_rule": "c2758 or c1822 or c1071 or c0388"}, {"subsystem": "Transport, Inner Membrane", "name": "D-galactonate transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALCTNt2pp"]}, "metabolites": {"galctn__D_c": 1.0, "galctn__D_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GALCTNt2pp", "gene_reaction_rule": "c4612"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-galactonate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALCTNtex"]}, "metabolites": {"galctn__D_p": 1.0, "galctn__D_e": -1.0}, "id": "GALCTNtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Transport, Inner Membrane", "name": "D-galactarte transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALCTt2rpp"]}, "metabolites": {"galct__D_p": -1.0, "galct__D_c": 1.0, "h_p": -1.0, "h_c": 1.0}, "id": "GALCTt2rpp", "gene_reaction_rule": "c3353 or c3882"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-galactarte transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALCTtex"]}, "metabolites": {"galct__D_e": -1.0, "galct__D_p": 1.0}, "id": "GALCTtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Galactokinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALKr"]}, "metabolites": {"adp_c": 1.0, "gal_c": -1.0, "gal1p_c": 1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "GALKr", "gene_reaction_rule": "c2570 or c0833"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Aldose-1-epimerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALM2pp"]}, "metabolites": {"gal_p": 1.0, "gal_bD_p": -1.0}, "id": "GALM2pp", "gene_reaction_rule": "c0832"}, {"subsystem": "Alternate Carbon Metabolism", "name": "A-galactosidase (melibiose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALS3"]}, "metabolites": {"glc__D_c": 1.0, "melib_c": -1.0, "gal_c": 1.0, "h2o_c": -1.0}, "id": "GALS3", "gene_reaction_rule": "c5124"}, {"subsystem": "Transport, Inner Membrane", "name": "Galactitol transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALTptspp"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "galt1p_c": 1.0, "galt_p": -1.0}, "id": "GALTptspp", "gene_reaction_rule": "c2619 and c2618 and c2617 and c2950 and c2951"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Galactitol transport 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"name": "UTP-glucose-1-phosphate uridylyltransferase (irreversible)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALUi"]}, "metabolites": {"utp_c": -1.0, "ppi_c": 1.0, "udpg_c": 1.0, "h_c": -1.0, "g1p_c": -1.0}, "id": "GALUi", "gene_reaction_rule": "c1700"}, {"subsystem": "Transport, Inner Membrane", "name": "D-galactose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "gal_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "gal_p": -1.0, "pi_c": 1.0}, "id": "GALabcpp", "gene_reaction_rule": "(c2683 and c2684 and c2682) or (c5328 and c5325 and c5326 and c5327)"}, {"subsystem": "Transport, Inner Membrane", "name": "D-galactose transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALt2pp"]}, "metabolites": {"gal_p": -1.0, "gal_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GALt2pp", "gene_reaction_rule": "c3529"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-galactose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GALtex"]}, "metabolites": {"gal_p": 1.0, "gal_e": -1.0}, "id": "GALtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Transport, Inner Membrane", "name": "D-Glucosamine 6-phosphate transport via phosphate antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GAM6Pt6_2pp"]}, "metabolites": {"pi_p": 2.0, "gam6p_p": -1.0, "gam6p_c": 1.0, "pi_c": -2.0}, "id": "GAM6Pt6_2pp", "gene_reaction_rule": "c4590"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-glucosamine 6-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GAMAN6Ptex"]}, "metabolites": {"gam6p_p": 1.0, "gam6p_e": -1.0}, 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"gene_reaction_rule": "c4826"}, {"subsystem": "Glycine and Serine Metabolism", "name": "Glycine hydroxymethyltransferase, reversible", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GHMT2r"]}, "metabolites": {"mlthf_c": 1.0, "ser__L_c": -1.0, "thf_c": -1.0, "h2o_c": 1.0, "gly_c": 1.0}, "id": "GHMT2r", "gene_reaction_rule": "c3073"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Guanylate kinase (GMP:ATP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GK1"]}, "metabolites": {"gmp_c": -1.0, "gdp_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "GK1", "gene_reaction_rule": "c4473"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "1,4-alpha-glucan branching enzyme (glycogen -> bglycogen)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLBRAN2"]}, "metabolites": {"bglycogen_c": 1.0, "glycogen_c": -1.0}, "id": "GLBRAN2", "gene_reaction_rule": "c4219"}, {"subsystem": "Alternate Carbon 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c5366"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-gluconate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCNtex"]}, "metabolites": {"glcn_p": 1.0, "glcn_e": -1.0}, "id": "GLCNtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Glycogen phosphorylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCP"]}, "metabolites": {"pi_c": -1.0, "glycogen_c": -1.0, "g1p_c": 1.0}, "id": "GLCP", "gene_reaction_rule": "c4194"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Glycogen phosphorylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCP2"]}, "metabolites": {"bglycogen_c": -1.0, "pi_c": -1.0, "g1p_c": 1.0}, "id": "GLCP2", "gene_reaction_rule": "c4194"}, {"subsystem": "Alternate Carbon Metabolism", "name": "5-dehydro-4-deoxyglucarate aldolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCRAL"]}, "metabolites": {"pyr_c": 1.0, "5dh4dglc_c": -1.0, "2h3oppan_c": 1.0}, "id": "GLCRAL", "gene_reaction_rule": "c3881"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glucarate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCRD"]}, "metabolites": {"h2o_c": 1.0, "5dh4dglc_c": 1.0, "glcr_c": -1.0}, "id": "GLCRD", "gene_reaction_rule": "c3352 or gudD"}, {"subsystem": "Transport, Inner Membrane", "name": "D-glucarate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCRt2rpp"]}, "metabolites": {"glcr_p": -1.0, "glcr_c": 1.0, "h_p": -1.0, "h_c": 1.0}, "id": "GLCRt2rpp", "gene_reaction_rule": "c3882 or c3353"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-glucarate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCRtex"]}, "metabolites": {"glcr_e": -1.0, "glcr_p": 1.0}, "id": "GLCRtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Glycogen synthase (ADPGlc)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCS1"]}, "metabolites": {"adp_c": 1.0, "adpglc_c": -1.0, "glycogen_c": 1.0, "h_c": 1.0}, "id": "GLCS1", "gene_reaction_rule": "c4216"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Glucosyltransferase I (LPS core synthesis)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCTR1"]}, "metabolites": {"icolipa_c": -1.0, "udp_c": 1.0, "udpg_c": -1.0, "h_c": 1.0, "gicolipa_c": 1.0}, "id": "GLCTR1", "gene_reaction_rule": "c4455"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-glucuronate 1-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCUR1Ptex"]}, "metabolites": {"glcur1p_p": 1.0, "glcur1p_e": -1.0}, "id": "GLCUR1Ptex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Transport, Inner Membrane", "name": "D-glucuronate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCURt2rpp"]}, "metabolites": {"glcur_c": 1.0, "h_c": 1.0, "h_p": -1.0, "glcur_p": -1.0}, "id": "GLCURt2rpp", "gene_reaction_rule": "c4861 or c3851"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-glucuronat transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCURtex"]}, "metabolites": {"glcur_e": -1.0, "glcur_p": 1.0}, "id": "GLCURtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Transport, Inner Membrane", "name": "D-glucose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "glc__D_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "glc__D_c": 1.0, "pi_c": 1.0}, "id": "GLCabcpp", "gene_reaction_rule": "c2683 and c2684 and c2682"}, {"subsystem": "Transport, Inner Membrane", "name": "D-glucose transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCptspp"]}, "metabolites": {"pep_c": -1.0, "g6p_c": 1.0, "glc__D_p": -1.0, "pyr_c": 1.0}, "id": "GLCptspp", "gene_reaction_rule": "(c2952 and c2013 and c2950 and c2951) or (c2952 and c1373 and c2950 and c2951) or (c2223 and c2224 and c2226 and c2950 and c2951)"}, {"subsystem": "Transport, Inner Membrane", "name": "D-glucose transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCt2pp"]}, "metabolites": {"glc__D_c": 1.0, "glc__D_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GLCt2pp", "gene_reaction_rule": "c3529"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glucose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLCtex", "GLCtexi"]}, "metabolites": {"glc__D_p": 1.0, "glc__D_e": -1.0}, "id": "GLCtex_copy1", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Transport, Outer Membrane", "name": "Glucose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCtex", "GLCtexi"]}, "metabolites": {"glc__D_p": 1.0, "glc__D_e": -1.0}, "id": "GLCtex_copy2", "gene_reaction_rule": "c5006"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Glycogen debranching enzyme (bglycogen -> glycogen)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLDBRAN2"]}, "metabolites": {"bglycogen_c": -1.0, "glycogen_c": 1.0}, "id": "GLDBRAN2", "gene_reaction_rule": "c4218"}, {"subsystem": "Glycolysis/Gluconeogenesis", "name": "Glucose-1-phosphate adenylyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLGC"]}, "metabolites": {"h_c": -1.0, "ppi_c": 1.0, "adpglc_c": 1.0, "atp_c": -1.0, "g1p_c": -1.0}, "id": "GLGC", "gene_reaction_rule": "c4217"}, {"subsystem": "Glutamate Metabolism", "name": "Glutamine synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLNS"]}, "metabolites": {"atp_c": -1.0, "glu__L_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "nh4_c": -1.0, "gln__L_c": 1.0}, "id": "GLNS", "gene_reaction_rule": "c4819"}, {"subsystem": "tRNA Charging", "name": "Glutaminyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLNTRS"]}, "metabolites": {"glntrna_c": 1.0, "atp_c": -1.0, "trnagln_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "gln__L_c": -1.0}, "id": "GLNTRS", "gene_reaction_rule": "c0766"}, {"subsystem": "Transport, Inner Membrane", "name": "L-glutamine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLNabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "gln__L_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "gln__L_c": 1.0}, "id": "GLNabcpp", "gene_reaction_rule": "c0896 and c0895 and c0894"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-glutamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLNtex"]}, "metabolites": {"gln__L_e": -1.0, "gln__L_p": 1.0}, "id": "GLNtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Galactitol-1-phosphate dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLTPD"]}, "metabolites": {"nadh_c": 1.0, "tag6p__D_c": 1.0, "h_c": 1.0, "nad_c": -1.0, "galt1p_c": -1.0}, "id": "GLTPD", "gene_reaction_rule": "c2616"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Glutamate 5-kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLU5K"]}, "metabolites": {"glu__L_c": -1.0, "glu5p_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "GLU5K", "gene_reaction_rule": "c0389"}, {"subsystem": "Transport, Inner Membrane", "name": "4-aminobutyrate/glutamate antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLUABUTt7pp"]}, "metabolites": {"glu__L_p": -1.0, "glu__L_c": 1.0, "4abut_p": 1.0, "4abut_c": -1.0}, "id": "GLUABUTt7pp", "gene_reaction_rule": "c1921"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Gamma-glutamylcysteine synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUCYS"]}, "metabolites": {"cys__L_c": -1.0, "glucys_c": 1.0, "atp_c": -1.0, "glu__L_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "GLUCYS", "gene_reaction_rule": "c3245"}, {"subsystem": "Glutamate Metabolism", "name": "Glutamate Decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUDC"]}, "metabolites": {"glu__L_c": -1.0, "co2_c": 1.0, "h_c": -1.0, "4abut_c": 1.0}, "id": "GLUDC", "gene_reaction_rule": "c1922"}, {"subsystem": "Glutamate Metabolism", "name": "Glutamate dehydrogenase (NADP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLUDy"]}, "metabolites": {"akg_c": 1.0, "h2o_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "glu__L_c": -1.0, "h_c": 1.0, "nh4_c": 1.0}, "id": "GLUDy", "gene_reaction_rule": "c2162"}, {"subsystem": "Glutamate Metabolism", "name": "Glutaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUN"]}, "metabolites": {"glu__L_c": 1.0, "nh4_c": 1.0, "h2o_c": -1.0, "gln__L_c": -1.0}, "id": "GLUN", "gene_reaction_rule": "c2217 or c0605 or c1947"}, {"subsystem": "Glutamate Metabolism", "name": "Glutaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUNpp"]}, "metabolites": {"glu__L_p": 1.0, "gln__L_p": -1.0, "nh4_p": 1.0, "h2o_p": -1.0}, "id": "GLUNpp", "gene_reaction_rule": "c3543"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Glutamine phosphoribosyldiphosphate amidotransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUPRT"]}, "metabolites": {"pram_c": 1.0, "h2o_c": -1.0, "ppi_c": 1.0, "glu__L_c": 1.0, "prpp_c": -1.0, "gln__L_c": -1.0}, "id": "GLUPRT", "gene_reaction_rule": "c2856"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Glutamate racemase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLUR"]}, "metabolites": {"glu__D_c": -1.0, "glu__L_c": 1.0}, "id": "GLUR", "gene_reaction_rule": "c4930"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Glutamyl-tRNA reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUTRR"]}, "metabolites": {"nadp_c": 1.0, "nadph_c": -1.0, "glu1sa_c": 1.0, "trnaglu_c": 1.0, "h_c": -1.0, "glutrna_c": -1.0}, "id": "GLUTRR", "gene_reaction_rule": "c1668"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Glutamyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUTRS"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "trnaglu_c": -1.0, "amp_c": 1.0, "glutrna_c": 1.0, "glu__L_c": -1.0}, "id": "GLUTRS", "gene_reaction_rule": "c2936"}, {"subsystem": "Transport, Inner Membrane", "name": "L-glutamate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "glu__L_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "glu__L_p": -1.0, "pi_c": 1.0}, "id": "GLUabcpp", "gene_reaction_rule": "c0739 and c0738 and c0737 and c0736"}, {"subsystem": "Transport, Inner Membrane", "name": "L-glutamate transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLUt2rpp"]}, "metabolites": {"glu__L_p": -1.0, "glu__L_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GLUt2rpp", "gene_reaction_rule": "c5074"}, {"subsystem": "Transport, Inner Membrane", "name": "Na+/glutamate symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUt4pp"]}, "metabolites": {"na1_p": -1.0, "glu__L_p": -1.0, "glu__L_c": 1.0, "na1_c": 1.0}, "id": "GLUt4pp", "gene_reaction_rule": "c4478"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-glutamate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLUtex"]}, "metabolites": {"glu__L_p": 1.0, "glu__L_e": -1.0}, "id": "GLUtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Glyoxylate Metabolism", "name": "Glyoxalate carboligase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLXCL"]}, "metabolites": {"co2_c": 1.0, "glx_c": -2.0, "h_c": -1.0, "2h3oppan_c": 1.0}, "id": "GLXCL", "gene_reaction_rule": "c0622"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glyceraldehyde transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYALDtex"]}, "metabolites": {"glyald_e": -1.0, "glyald_p": 1.0}, "id": "GLYALDtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Transport, Inner Membrane", "name": "Glyceraldehyde facilitated diffusion (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYALDtpp"]}, "metabolites": {"glyald_c": 1.0, "glyald_p": -1.0}, "id": "GLYALDtpp", "gene_reaction_rule": "c4879"}, {"subsystem": "Glycine and Serine Metabolism", "name": "Glycine C-acetyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYAT"]}, "metabolites": {"coa_c": 1.0, "gly_c": -1.0, "accoa_c": -1.0, "2aobut_c": 1.0}, "id": "GLYAT", "gene_reaction_rule": "c4444"}, {"subsystem": "Transport, Inner Membrane", "name": "Glycine betaine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYBabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "glyb_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "glyb_p": -1.0}, "id": "GLYBabcpp", "gene_reaction_rule": "c2658 and c2659 and c2660 and c2661"}, {"subsystem": "Transport, Inner Membrane", "name": "Glycine betaine transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYBt2pp", "GLYBt6pp"]}, "metabolites": {"glyb_c": 1.0, "h_c": 1.0, "h_p": -1.0, "glyb_p": -1.0}, "id": "GLYBt2pp_copy1", "gene_reaction_rule": "c5116"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glycine betaine transport 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1.0, "h_p": -1.0}, "id": "GLYCLTt2rpp", "gene_reaction_rule": "c3704"}, {"subsystem": "Transport, Inner Membrane", "name": "Glycolate transport via sodium symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCLTt4pp"]}, "metabolites": {"glyclt_p": -1.0, "na1_p": -1.0, "na1_c": 1.0, "glyclt_c": 1.0}, "id": "GLYCLTt4pp", "gene_reaction_rule": "c5062"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glycolate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYCLTtex"]}, "metabolites": {"glyclt_p": 1.0, "glyclt_e": -1.0}, "id": "GLYCLTtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glycolate oxidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCTO2"]}, "metabolites": {"q8h2_c": 1.0, "glyclt_c": -1.0, "glx_c": 1.0, "q8_c": -1.0}, "id": "GLYCTO2", "gene_reaction_rule": "c3709 and glcF and glcE"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glycolate oxidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCTO3"]}, "metabolites": {"mqn8_c": -1.0, "glyclt_c": -1.0, "glx_c": 1.0, "mql8_c": 1.0}, "id": "GLYCTO3", "gene_reaction_rule": "c3709 and glcF and glcE"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Glycolate oxidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLYCTO4"]}, "metabolites": {"glyclt_c": -1.0, "glx_c": 1.0, "2dmmq8_c": -1.0, "2dmmql8_c": 1.0}, "id": "GLYCTO4", "gene_reaction_rule": "c3709 and glcF and glcE"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Glycerol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYCtex"]}, "metabolites": {"glyc_e": -1.0, "glyc_p": 1.0}, "id": "GLYCtex", "gene_reaction_rule": "c0388 or c1071 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{"original_bigg_ids": ["IDONtex"]}, "metabolites": {"idon__L_p": 1.0, "idon__L_e": -1.0}, "id": "IDONtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Histidine Metabolism", "name": "Imidazole-glycerol-3-phosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IG3PS"]}, "metabolites": {"aicar_c": 1.0, "glu__L_c": 1.0, "eig3p_c": 1.0, "h_c": 1.0, "prlp_c": -1.0, "gln__L_c": -1.0}, "id": "IG3PS", "gene_reaction_rule": "c2550 and c2552"}, {"subsystem": "Histidine Metabolism", "name": "Imidazoleglycerol-phosphate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IGPDH"]}, "metabolites": {"h2o_c": 1.0, "imacp_c": 1.0, "eig3p_c": -1.0}, "id": "IGPDH", "gene_reaction_rule": "c2549"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Isoleucine transaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ILETA"]}, "metabolites": {"akg_c": -1.0, "3mop_c": 1.0, "glu__L_c": 1.0, "ile__L_c": -1.0}, "id": "ILETA", "gene_reaction_rule": "c4692"}, {"subsystem": "tRNA Charging", "name": "Isoleucyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ILETRS"]}, "metabolites": {"iletrna_c": 1.0, "trnaile_c": -1.0, "atp_c": -1.0, "ile__L_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0}, "id": "ILETRS", "gene_reaction_rule": "c0030"}, {"subsystem": "Transport, Inner Membrane", "name": "L-isoleucine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ILEabcpp"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "atp_c": -1.0, "ile__L_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "ile__L_p": -1.0}, "id": "ILEabcpp", "gene_reaction_rule": "c4244 and c4245 and c4247 and c4253 and c4246"}, {"subsystem": "Transport, Inner Membrane", "name": "L-isoleucine reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ILEt2rpp"]}, "metabolites": {"ile__L_c": 1.0, "ile__L_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "ILEt2rpp", "gene_reaction_rule": "c0511"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-isoleucine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ILEtex"]}, "metabolites": {"ile__L_p": 1.0, "ile__L_e": -1.0}, "id": "ILEtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "IMP cyclohydrolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IMPC"]}, "metabolites": {"h2o_c": -1.0, "fprica_c": 1.0, "imp_c": -1.0}, "id": "IMPC", "gene_reaction_rule": "c4964"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "IMP dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IMPD"]}, "metabolites": {"xmp_c": 1.0, "h2o_c": -1.0, "h_c": 1.0, "nad_c": -1.0, "nadh_c": 1.0, "imp_c": -1.0}, "id": "IMPD", "gene_reaction_rule": "c3027"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "IMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IMPtex"]}, "metabolites": {"imp_e": -1.0, "imp_p": 1.0}, "id": "IMPtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Transport, Inner Membrane", "name": "Indole transport via proton symport, reversible (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["INDOLEt2rpp"]}, "metabolites": {"indole_c": 1.0, "indole_p": -1.0, "h_p": -1.0, "h_c": 1.0}, "id": "INDOLEt2rpp", "gene_reaction_rule": "c3914"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Indole transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["INDOLEtex"]}, "metabolites": {"indole_e": -1.0, "indole_p": 1.0}, "id": "INDOLEtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Transport, Inner Membrane", "name": "Na+/myo-inositol symporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["INOSTt4pp"]}, "metabolites": {"na1_p": -1.0, "na1_c": 1.0, "inost_c": 1.0, "inost_p": -1.0}, "id": "INOSTt4pp", "gene_reaction_rule": "c4602"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Inosine hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["INSH"]}, "metabolites": {"rib__D_c": 1.0, "h2o_c": -1.0, "hxan_c": 1.0, "ins_c": -1.0}, "id": "INSH", "gene_reaction_rule": "rihC"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Insosine kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["INSK"]}, "metabolites": {"adp_c": 1.0, "imp_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "ins_c": -1.0}, "id": "INSK", "gene_reaction_rule": "c0597"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Inositol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["INSTtex"]}, "metabolites": {"inost_e": -1.0, "inost_p": 1.0}, "id": "INSTtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Transport, Inner Membrane", "name": "Inosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["INSt2pp", "INSt2rpp"]}, "metabolites": {"ins_p": -1.0, "h_c": 1.0, "h_p": -1.0, "ins_c": 1.0}, "id": "INSt2pp_copy1", "gene_reaction_rule": "c3552"}, {"subsystem": "Transport, Inner Membrane", "name": "Inosine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["INSt2pp", "INSt2rpp"]}, "metabolites": {"ins_p": -1.0, "h_c": 1.0, "h_p": -1.0, "ins_c": 1.0}, "id": "INSt2pp_copy2", "gene_reaction_rule": "c2939"}, {"subsystem": "Transport, Outer Membrane", "name": "Inosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["INStex"]}, "metabolites": {"ins_e": -1.0, "ins_p": 1.0}, "id": "INStex", "gene_reaction_rule": "c0521"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Isopentenyl-diphosphate D-isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IPDDI"]}, "metabolites": {"dmpp_c": 1.0, "ipdp_c": -1.0}, "id": "IPDDI", "gene_reaction_rule": "c3467"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (ipdp)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IPDPS"]}, "metabolites": {"h2o_c": 1.0, "ipdp_c": 1.0, "h2mb4p_c": -1.0, "h_c": -1.0, "nad_c": 1.0, "nadh_c": -1.0}, "id": "IPDPS", "gene_reaction_rule": "c0033"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "3-isopropylmalate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IPMD"]}, "metabolites": {"3c4mop_c": 1.0, "3c2hmp_c": -1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "IPMD", "gene_reaction_rule": "c0090"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "3-isopropylmalate dehydratase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IPPMIa"]}, "metabolites": {"2ippm_c": 1.0, "h2o_c": 1.0, "3c2hmp_c": -1.0}, "id": "IPPMIa", "gene_reaction_rule": "c0087 and c0089"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "2-isopropylmalate hydratase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["IPPMIb"]}, "metabolites": {"2ippm_c": -1.0, "h2o_c": -1.0, "3c3hmp_c": 1.0}, "id": "IPPMIb", "gene_reaction_rule": "c0087 and c0089"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "2-isopropylmalate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["IPPS"]}, "metabolites": {"h2o_c": -1.0, "accoa_c": -1.0, "3mob_c": -1.0, "coa_c": 1.0, "h_c": 1.0, "3c3hmp_c": 1.0}, "id": "IPPS", "gene_reaction_rule": "c0091"}, {"subsystem": "Transport, Inner Membrane", "name": "Isethionate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ISETACabcpp"]}, "metabolites": {"isetac_c": 1.0, "h2o_c": -1.0, "atp_c": -1.0, "isetac_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "ISETACabcpp", "gene_reaction_rule": "(c0472 and c0473 and c0475) or (c1079 and c1076 and c1077)"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Isethionate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["ISETACtex"]}, "metabolites": {"isetac_p": 1.0, "isetac_e": -1.0}, "id": "ISETACtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Transport, Inner Membrane", "name": "KDO(2)-lipid IV A transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["K2L4Aabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "kdo2lipid4_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "kdo2lipid4_c": -1.0, "pi_c": 1.0}, "id": "K2L4Aabcpp", "gene_reaction_rule": "c1054"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "KDO(2)-lipid IV A transport via ABC system (periplasm to extracellular)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["K2L4Aabctex"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "kdo2lipid4_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "kdo2lipid4_e": 1.0}, "id": "K2L4Aabctex", "gene_reaction_rule": "c3960 and c3961 and c3959 and c5362 and c5363"}, {"subsystem": "Valine, Leucine, and Isoleucine 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{"subsystem": "Membrane Lipid Metabolism", "name": "Beta-ketoacyl-ACP synthase (2)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KAS15"]}, "metabolites": {"malACP_c": -1.0, "coa_c": 1.0, "h_c": -1.0, "accoa_c": -1.0, "actACP_c": 1.0, "co2_c": 1.0}, "id": "KAS15", "gene_reaction_rule": "c1360"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "3-deoxy-manno-octulosonate cytidylyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KDOCT2"]}, "metabolites": {"ctp_c": -1.0, "ckdo_c": 1.0, "ppi_c": 1.0, "kdo_c": -1.0}, "id": "KDOCT2", "gene_reaction_rule": "c1059"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "3-deoxy-manno-octulosonate-8-phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KDOPP"]}, "metabolites": {"kdo8p_c": -1.0, "h2o_c": -1.0, "kdo_c": 1.0, "pi_c": 1.0}, "id": "KDOPP", "gene_reaction_rule": "c3958"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "3-deoxy -D-manno-octulosonic -acid 8-phosphate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KDOPS"]}, "metabolites": {"pep_c": -1.0, "kdo8p_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0, "ara5p_c": -1.0}, "id": "KDOPS", "gene_reaction_rule": "c1674"}, {"subsystem": "Alternate Carbon Metabolism", "name": "3-keto-L-gulonate 6-phosphate decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["KG6PDC"]}, "metabolites": {"xu5p__L_c": 1.0, "3dhgulnp_c": -1.0, "co2_c": 1.0, "h_c": -1.0}, "id": "KG6PDC", "gene_reaction_rule": "c5285 or c4404"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Potassium ABC transporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["Kabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "k_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "k_c": 1.0, "pi_c": 1.0}, "id": "Kabcpp", "gene_reaction_rule": "(c0783 and c0782 and c0781) or (c0783 and c0782 and c0781 and c0784)"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Potassium transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["Kt2pp"]}, "metabolites": {"k_p": -1.0, "k_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "Kt2pp", "gene_reaction_rule": "(c1768 and c4050 and c4796) or c1715 or c4675"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Potassium transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["Kt3pp"]}, "metabolites": {"k_p": 1.0, "k_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "Kt3pp", "gene_reaction_rule": "c1676 or c0927 or c4125 or c0057"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Potassium transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": 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-1000.0, "notes": {"original_bigg_ids": ["LALADGLUtex"]}, "metabolites": {"LalaDglu_p": 1.0, "LalaDglu_e": -1.0}, "id": "LALADGLUtex", "gene_reaction_rule": "c2758 or c1822 or c0388 or c1071"}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanyl-D-glutamate transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LALADGLUtpp"]}, "metabolites": {"LalaDglu_p": -1.0, "LalaDglu_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "LALADGLUtpp", "gene_reaction_rule": "c2026 or c4295 or c5139 or c0788"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-alanyl-L-glutamate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LALALGLUtex"]}, "metabolites": {"LalaLglu_p": 1.0, "LalaLglu_e": -1.0}, "id": "LALALGLUtex", "gene_reaction_rule": "c2758 or c1822 or c0388 or c1071"}, {"subsystem": "Transport, Inner Membrane", "name": "L-alanyl-L-glutamate transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LALALGLUtpp"]}, "metabolites": {"LalaLglu_p": -1.0, "LalaLglu_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "LALALGLUtpp", "gene_reaction_rule": "c2026 or c4295 or c5139 or c0788"}, {"subsystem": "Methylglyoxal Metabolism", "name": "D-Lactaldehyde:NAD+ 1-oxidoreductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LALDO2x"]}, "metabolites": {"nad_c": 1.0, "nadh_c": -1.0, "h_c": -1.0, "mthgxl_c": -1.0, "lald__D_c": 1.0}, "id": "LALDO2x", "gene_reaction_rule": "c4904"}, {"subsystem": "Methylglyoxal Metabolism", "name": "L-Lactaldehyde:NADP+ 1-oxidoreductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LALDO3"]}, "metabolites": {"nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "lald__L_c": 1.0, "mthgxl_c": -1.0}, "id": "LALDO3", "gene_reaction_rule": ""}, {"subsystem": "Murein Recycling", "name": "L-alanyl-gamma-L-glutamate peptidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LALGP"]}, "metabolites": {"LalaLglu_c": -1.0, "ala__L_c": 1.0, "glu__L_c": 1.0, "h2o_c": -1.0}, "id": "LALGP", "gene_reaction_rule": "c0383"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Lactaldehyde dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LCADi"]}, "metabolites": {"h2o_c": -1.0, "lald__L_c": -1.0, "lac__L_c": 1.0, "h_c": 2.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "LCADi", "gene_reaction_rule": "c1842"}, {"subsystem": "Methylglyoxal Metabolism", "name": "Lacaldehyde reductase (R-propane-1,2-diol forming)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LCARR"]}, "metabolites": {"lald__D_c": -1.0, "nadh_c": -1.0, "12ppd__R_c": 1.0, "nad_c": 1.0, "h_c": -1.0}, "id": "LCARR", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Lacaldehyde reductase (S-propane-1,2-diol forming)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LCARS"]}, "metabolites": {"nad_c": 1.0, "nadh_c": -1.0, "12ppd__S_c": 1.0, "h_c": -1.0, "lald__L_c": -1.0}, "id": "LCARS", "gene_reaction_rule": "c3367"}, {"subsystem": "Transport, Inner Membrane", "name": "Lactose transport via proton aniport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LCTSt3ipp"]}, "metabolites": {"lcts_c": -1.0, "lcts_p": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "LCTSt3ipp", "gene_reaction_rule": "c2706 or c1950"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Lactose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LCTStex"]}, "metabolites": {"lcts_p": 1.0, "lcts_e": -1.0}, "id": "LCTStex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Transport, Inner Membrane", "name": "Lactose transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LCTStpp"]}, "metabolites": {"lcts_c": 1.0, "lcts_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "LCTStpp", "gene_reaction_rule": "c0458"}, {"subsystem": "Pyruvate Metabolism", "name": "D-lactate dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LDH_D"]}, "metabolites": {"pyr_c": 1.0, "nadh_c": 1.0, "lac__D_c": -1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "LDH_D", "gene_reaction_rule": "c2664 or c1827"}, {"subsystem": "Oxidative Phosphorylation", "name": "D-lactate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LDH_D2"]}, "metabolites": {"q8h2_c": 1.0, "pyr_c": 1.0, "lac__D_c": -1.0, "q8_c": -1.0}, "id": "LDH_D2", "gene_reaction_rule": "c2664"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "Leucine transaminase (irreversible)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LEUTAi"]}, "metabolites": {"akg_c": 1.0, "glu__L_c": -1.0, "4mop_c": -1.0, "leu__L_c": 1.0}, "id": "LEUTAi", "gene_reaction_rule": "c4692 or c5031"}, {"subsystem": "tRNA Charging", "name": "Leucyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LEUTRS"]}, "metabolites": {"leutrna_c": 1.0, "leu__L_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "trnaleu_c": -1.0}, "id": "LEUTRS", "gene_reaction_rule": "c0733"}, {"subsystem": "Transport, Inner Membrane", "name": "L-leucine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LEUabcpp"]}, "metabolites": {"leu__L_c": 1.0, "atp_c": -1.0, "h2o_c": -1.0, "leu__L_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "LEUabcpp", "gene_reaction_rule": "(c4244 and c4245 and c4247 and c4253 and c4246) or (c4244 and c4245 and c4247 and c4248 and c4246)"}, {"subsystem": "Transport, Inner Membrane", "name": "L-leucine reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LEUt2rpp"]}, "metabolites": {"leu__L_p": -1.0, "leu__L_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": "LEUt2rpp", "gene_reaction_rule": "c0511"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-leucine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LEUtex"]}, "metabolites": {"leu__L_p": 1.0, "leu__L_e": -1.0}, "id": "LEUtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Methylglyoxal Metabolism", "name": "Lactoylglutathione lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LGTHL"]}, "metabolites": {"gthrd_c": -1.0, "lgt__S_c": 1.0, "mthgxl_c": -1.0}, "id": "LGTHL", "gene_reaction_rule": "c2044"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Lipid (cold) A transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPACabcpp"]}, "metabolites": {"h2o_c": -1.0, "lipa_cold_c": -1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "lipa_cold_p": 1.0, "pi_c": 1.0}, "id": "LIPACabcpp", "gene_reaction_rule": "c1054"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Core oligosaccharide lipid A:hexadecanoate transferase (n-C16:0) (extracellular membrane)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPAHT2ex"]}, "metabolites": {"hdca_e": -1.0, "h_e": -1.0, "h2o_e": 1.0, "hacolipa_e": 1.0, "colipa_e": -1.0}, "id": "LIPAHT2ex", "gene_reaction_rule": "c0713"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Lipid A:hexadecanoate transferase (n-C16:0) (extracellular membrane)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LIPAHTex"]}, "metabolites": {"hdca_e": -1.0, "lipa_e": 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"Lysophospholipase L2 (2-acylglycerophosphoglycerol, n-C18:1)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LPLIPAL2G181"]}, "metabolites": {"ocdcea_c": 1.0, "h2o_c": -1.0, "2agpg181_c": -1.0, "h_c": 1.0, "g3pg_c": 1.0}, "id": "LPLIPAL2G181", "gene_reaction_rule": "c4747"}, {"subsystem": "Glycine and Serine Metabolism", "name": "L-serine dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LSERDHr"]}, "metabolites": {"2amsa_c": 1.0, "ser__L_c": -1.0, "nadp_c": -1.0, "nadph_c": 1.0, "h_c": 1.0}, "id": "LSERDHr", "gene_reaction_rule": "c1965"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Lysine decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSDC"]}, "metabolites": {"15dap_c": 1.0, "co2_c": 1.0, "lys__L_c": -1.0, "h_c": -1.0}, "id": "LYSDC", "gene_reaction_rule": "c0224"}, {"subsystem": "tRNA Charging", "name": "Lysyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSTRS"]}, "metabolites": {"trnalys_c": -1.0, "lys__L_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "lystrna_c": 1.0}, "id": "LYSTRS", "gene_reaction_rule": "c3469"}, {"subsystem": "Transport, Inner Membrane", "name": "L-lysine transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSabcpp"]}, "metabolites": {"h2o_c": -1.0, "lys__L_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "lys__L_p": -1.0, "pi_c": 1.0}, "id": "LYSabcpp", "gene_reaction_rule": "argT and c2849 and c2848 and c2850"}, {"subsystem": "Transport, Inner Membrane", "name": "L-lysine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSt2pp"]}, "metabolites": {"lys__L_c": 1.0, "h_c": 1.0, "h_p": -1.0, "lys__L_p": -1.0}, "id": "LYSt2pp", "gene_reaction_rule": "c2691"}, {"subsystem": "Transport, Inner Membrane", "name": "L-lysine transport out via proton antiport (cytoplasm to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYSt3pp"]}, "metabolites": {"lys__L_c": -1.0, "h_c": 1.0, "h_p": -1.0, "lys__L_p": 1.0}, "id": "LYSt3pp", "gene_reaction_rule": "c3501"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-lysine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LYStex"]}, "metabolites": {"lys__L_e": -1.0, "lys__L_p": 1.0}, "id": "LYStex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Lyxose isomerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYXI"]}, "metabolites": {"xylu__L_c": 1.0, "lyx__L_c": -1.0}, "id": "LYXI", "gene_reaction_rule": "c4852"}, {"subsystem": "Transport, Inner Membrane", "name": "L-Lyxose transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["LYXt2pp"]}, "metabolites": {"lyx__L_p": -1.0, "lyx__L_c": 1.0, "h_p": -1.0, "h_c": 1.0}, "id": "LYXt2pp", "gene_reaction_rule": "c4857"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-Lyxose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["LYXtex"]}, "metabolites": {"lyx__L_e": -1.0, "lyx__L_p": 1.0}, "id": "LYXtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Mannitol-1-phosphate 5-dehydrogenase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["M1PD"]}, "metabolites": {"h_c": 1.0, "nadh_c": 1.0, "mnl1p_c": -1.0, "nad_c": -1.0, "f6p_c": 1.0}, "id": "M1PD", "gene_reaction_rule": "c4417"}, {"subsystem": "Membrane Lipid Metabolism", "name": "Malonyl-ACP decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MACPD"]}, "metabolites": {"acACP_c": 1.0, "co2_c": 1.0, "malACP_c": -1.0, "h_c": -1.0}, "id": "MACPD", "gene_reaction_rule": "c2869"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Malonyl-CoA methyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALCOAMT"]}, "metabolites": {"malcoame_c": 1.0, "amet_c": -1.0, "malcoa_c": -1.0, "ahcys_c": 1.0}, "id": "MALCOAMT", "gene_reaction_rule": "c0857"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Malate decarboxylating oxidoreductase (decarboxylating)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALDDH"]}, "metabolites": {"pyr_c": 1.0, "nadh_c": 1.0, "co2_c": 1.0, "mal__D_c": -1.0, "nad_c": -1.0}, "id": "MALDDH", "gene_reaction_rule": "c2207"}, {"subsystem": "Transport, Inner Membrane", "name": "D-Malate transport via proton symport (2 H) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALDt2_2pp"]}, "metabolites": {"mal__D_p": -1.0, "mal__D_c": 1.0, "h_c": 2.0, "h_p": -2.0}, "id": "MALDt2_2pp", "gene_reaction_rule": "c4340"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-Malate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MALDtex"]}, "metabolites": {"mal__D_p": 1.0, "mal__D_e": -1.0}, "id": "MALDtex", "gene_reaction_rule": "c2758 or c1822 or c0388 or c1071"}, {"subsystem": "Anaplerotic Reactions", "name": "Malate synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALS"]}, "metabolites": {"h2o_c": -1.0, "mal__L_c": 1.0, "glx_c": -1.0, "h_c": 1.0, "accoa_c": -1.0, "coa_c": 1.0}, "id": "MALS", "gene_reaction_rule": "c4971 or c3705"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltose O-acetyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MALTATr"]}, "metabolites": {"coa_c": 1.0, "malt_c": -1.0, "acmalt_c": 1.0, "accoa_c": -1.0}, "id": "MALTATr", "gene_reaction_rule": "c0577"}, {"subsystem": "Transport, Inner Membrane", "name": "Maltohexaose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTHXabcpp"]}, "metabolites": {"h2o_c": -1.0, "malthx_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "malthx_p": -1.0, "pi_c": 1.0}, "id": "MALTHXabcpp", "gene_reaction_rule": "c5004 and c5003 and c5002 and c5005"}, {"subsystem": "Transport, Outer Membrane", "name": "Maltohexaose transport via diffusion (extracellular to periplasm) irreversible", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTHXtexi"]}, "metabolites": {"malthx_e": -1.0, "malthx_p": 1.0}, "id": "MALTHXtexi", "gene_reaction_rule": "c5006"}, {"subsystem": "Transport, Inner Membrane", "name": "Maltopentaose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTPTabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "maltpt_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "maltpt_c": 1.0, "pi_c": 1.0}, "id": "MALTPTabcpp", "gene_reaction_rule": "c5004 and c5003 and c5002 and c5005"}, {"subsystem": "Transport, Outer Membrane", "name": "MaltopentaoseMaltotriose transport via diffusion (extracellular to periplasm) irreversible", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTPTtexi"]}, "metabolites": {"maltpt_p": 1.0, "maltpt_e": -1.0}, "id": "MALTPTtexi", "gene_reaction_rule": "c5006"}, {"subsystem": "Transport, Inner Membrane", "name": "Maltotriose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTTRabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "malttr_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "malttr_c": 1.0}, "id": "MALTTRabcpp", "gene_reaction_rule": "c5004 and c5003 and c5002 and c5005"}, {"subsystem": "Transport, Outer Membrane", "name": "Maltotriose transport via diffusion (extracellular to periplasm) irreversible", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTTRtexi"]}, "metabolites": {"malttr_e": -1.0, "malttr_p": 1.0}, "id": "MALTTRtexi", "gene_reaction_rule": "c5006"}, {"subsystem": "Transport, Inner Membrane", "name": "Maltotetraose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTTTRabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "maltttr_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "maltttr_p": -1.0}, "id": "MALTTTRabcpp", "gene_reaction_rule": "c5004 and c5003 and c5002 and c5005"}, {"subsystem": "Transport, Outer Membrane", "name": "MaltotetraoseMaltotriose transport via diffusion (extracellular to periplasm) irreversible", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTTTRtexi"]}, "metabolites": {"maltttr_e": -1.0, "maltttr_p": 1.0}, "id": "MALTTTRtexi", "gene_reaction_rule": "c5006"}, {"subsystem": "Transport, Inner Membrane", "name": "Maltose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "malt_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "malt_c": 1.0, "pi_c": 1.0}, "id": "MALTabcpp", "gene_reaction_rule": "c5004 and c5003 and c5002 and c5005"}, {"subsystem": "Transport, Inner Membrane", "name": "Maltose transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MALTptspp"]}, "metabolites": {"pep_c": -1.0, "malt_p": -1.0, "malt6p_c": 1.0, "pyr_c": 1.0}, "id": "MALTptspp", "gene_reaction_rule": "c2952 and c2013 and c2950 and c2951"}, {"subsystem": "Transport, Outer Membrane", "name": "MaltoseMaltotriose transport via diffusion (extracellular to periplasm) irreversible", "upper_bound": 1000.0, "lower_bound": 0.0, 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["MALt3pp"]}, "metabolites": {"mal__L_p": 1.0, "mal__L_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "MALt3pp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Malate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MALtex"]}, "metabolites": {"mal__L_p": 1.0, "mal__L_e": -1.0}, "id": "MALtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "Mannose-1-phosphate guanylyltransferase (GDP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MAN1PT2"]}, "metabolites": {"man1p_c": -1.0, "pi_c": 1.0, "gdp_c": -1.0, "h_c": -1.0, "gdpmann_c": 1.0}, "id": "MAN1PT2", "gene_reaction_rule": "c2575"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Mannose-6-phosphate isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MAN6PI"]}, "metabolites": {"man6p_c": -1.0, "f6p_c": 1.0}, "id": "MAN6PI", "gene_reaction_rule": "c2005"}, {"subsystem": "Transport, Inner Membrane", "name": "Mannose-6-phosphate transport via phosphate antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MAN6Pt6_2pp"]}, "metabolites": {"man6p_p": -1.0, "pi_p": 2.0, "man6p_c": 1.0, "pi_c": -2.0}, "id": "MAN6Pt6_2pp", "gene_reaction_rule": "c4590"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Mannose 6-phosphate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MAN6Ptex"]}, "metabolites": {"man6p_p": 1.0, "man6p_e": -1.0}, "id": "MAN6Ptex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Mannonate oxidoreductase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MANAO"]}, "metabolites": {"fruur_c": 1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0, "mana_c": -1.0}, "id": "MANAO", "gene_reaction_rule": "c5403"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "2-O-alpha-mannosyl-D-glycerate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MANGLYCtex"]}, "metabolites": {"manglyc_e": -1.0, "manglyc_p": 1.0}, "id": "MANGLYCtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Transport, Inner Membrane", "name": "D-mannose transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MANptspp"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "man6p_c": 1.0, "man_p": -1.0}, "id": "MANptspp", "gene_reaction_rule": "c2223 and c2224 and c2226 and c2950 and c2951"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "D-mannose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": 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"lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDCP2App"]}, "metabolites": {"h2o_p": -1.0, "murein5p5p_p": -1.0, "alaala_p": 1.0, "murein5p3p_p": 1.0}, "id": "MLDCP2App", "gene_reaction_rule": ""}, {"subsystem": "Murein Biosynthesis", "name": "Murein L,D-carboxypeptidase (murein4p3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDCP2Bpp"]}, "metabolites": {"h2o_p": -1.0, "murein3p3p_p": 1.0, "murein4p3p_p": -1.0, "ala__D_p": 1.0}, "id": "MLDCP2Bpp", "gene_reaction_rule": ""}, {"subsystem": "Murein Biosynthesis", "name": "Murein L,D-carboxypeptidase (murein5px3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDCP3App"]}, "metabolites": {"h2o_p": -1.0, "murein3px3p_p": 1.0, "murein5px3p_p": -1.0, "alaala_p": 1.0}, "id": "MLDCP3App", "gene_reaction_rule": ""}, {"subsystem": "Murein Recycling", "name": "Murein L,D-endopeptidase (murein3px3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDEP1pp"]}, "metabolites": {"h2o_p": -1.0, "murein3px3p_p": -1.0, "murein3p3p_p": 1.0}, "id": "MLDEP1pp", "gene_reaction_rule": ""}, {"subsystem": "Murein Recycling", "name": "Murein L,D-endopeptidase (murein5px3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLDEP2pp"]}, "metabolites": {"h2o_p": -1.0, "murein5px3p_p": -1.0, "murein5p3p_p": 1.0}, "id": "MLDEP2pp", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltotriose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG1"]}, "metabolites": {"glc__D_c": 1.0, "h2o_c": -1.0, "malt_c": 1.0, "malttr_c": -1.0}, "id": "MLTG1", "gene_reaction_rule": "c0513"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltotetraose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG2"]}, "metabolites": {"glc__D_c": 1.0, "h2o_c": -1.0, "malttr_c": 1.0, "maltttr_c": -1.0}, "id": "MLTG2", "gene_reaction_rule": "c0513"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltopentaose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG3"]}, "metabolites": {"maltpt_c": -1.0, "glc__D_c": 1.0, "h2o_c": -1.0, "maltttr_c": 1.0}, "id": "MLTG3", "gene_reaction_rule": "c0513"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltohexaose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG4"]}, "metabolites": {"maltpt_c": 1.0, "glc__D_c": 1.0, "h2o_c": -1.0, "malthx_c": -1.0}, "id": "MLTG4", "gene_reaction_rule": "c0513"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin glucosidase (maltoheptaose)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTG5"]}, "metabolites": {"glc__D_c": 1.0, "malthx_c": 1.0, "h2o_c": -1.0, "malthp_c": -1.0}, "id": "MLTG5", "gene_reaction_rule": "c0513"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein4p4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY1pp"]}, "metabolites": {"murein4p4p_p": -1.0, "anhgm4p_p": 2.0}, "id": "MLTGY1pp", "gene_reaction_rule": "c3081 or c3551 or c5479 or c3384 or c3255 or c1643"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein4p3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY2pp"]}, "metabolites": {"murein4p3p_p": -1.0, "anhgm3p_p": 1.0, "anhgm4p_p": 1.0}, "id": "MLTGY2pp", "gene_reaction_rule": "c1643 or c3081 or c3551 or c5479 or c3384 or c3255"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein3p3p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY3pp"]}, "metabolites": {"murein3p3p_p": -1.0, "anhgm3p_p": 2.0}, "id": "MLTGY3pp", "gene_reaction_rule": "c1643 or c3551 or c3081 or c5479 or c3384 or c3255"}, {"subsystem": "Murein Recycling", "name": "Murein lytic transglycosylase (murein4px4p4p) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MLTGY4pp"]}, "metabolites": {"murein4px4p_p": 1.0, "murein4px4p4p_p": -1.0, "anhgm4p_p": 1.0}, "id": "MLTGY4pp", "gene_reaction_rule": "c3255 or c1643 or c3551 or c3081 or c5479 or c3384"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin phosphorylase (maltopentaose)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MLTP1"]}, "metabolites": {"maltpt_c": -1.0, "pi_c": -1.0, "g1p_c": 1.0, "maltttr_c": 1.0}, "id": "MLTP1", "gene_reaction_rule": "c4194"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin phosphorylase (maltohexaose)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MLTP2"]}, "metabolites": {"maltpt_c": 1.0, "pi_c": -1.0, "malthx_c": -1.0, "g1p_c": 1.0}, "id": "MLTP2", "gene_reaction_rule": "c4194"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Maltodextrin phosphorylase (maltoheptaose)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MLTP3"]}, "metabolites": {"malthx_c": 1.0, "pi_c": -1.0, "malthp_c": -1.0, "g1p_c": 1.0}, "id": "MLTP3", "gene_reaction_rule": "c4194"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "S-methyl-L-methionine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MMETtex"]}, "metabolites": {"mmet_e": -1.0, "mmet_p": 1.0}, "id": "MMETtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Methylmalonyl-CoA mutase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MMM"]}, "metabolites": {"mmcoa__S_c": 1.0, "succoa_c": -1.0}, "id": "MMM", "gene_reaction_rule": "c3498"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Manganese (Mn+2) transport out via proton antiport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MN2t3pp"]}, "metabolites": {"mn2_p": 1.0, "mn2_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "MN2t3pp", "gene_reaction_rule": "c4866 or c0827"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Manganese transport in via permease (no H+)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MN2tpp"]}, "metabolites": {"mn2_p": -1.0, "mn2_c": 1.0}, "id": "MN2tpp", "gene_reaction_rule": "c3789"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Mannose 6-phosphate phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MN6PP"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "man6p_c": -1.0, "man_c": 1.0}, "id": "MN6PP", "gene_reaction_rule": "c0907"}, {"subsystem": "Transport, Inner Membrane", "name": "Mannitol transport via PEP:Pyr PTS (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MNLptspp"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "mnl_p": -1.0, "mnl1p_c": 1.0}, "id": "MNLptspp", "gene_reaction_rule": "c4416 and c2950 and c2951"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Mannitol transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MNLtex"]}, "metabolites": {"mnl_p": 1.0, "mnl_e": -1.0}, "id": "MNLtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Alternate Carbon Metabolism", "name": "D-mannonate hydrolyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MNNH"]}, "metabolites": {"h2o_c": 1.0, "2ddglcn_c": 1.0, "mana_c": -1.0}, "id": "MNNH", "gene_reaction_rule": "c5402"}, {"subsystem": "Transport, Inner Membrane", "name": "Manganese (Mn+2) transport in via 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Biosynthesis / Recycling", "name": "3-deoxy-D-manno-octulosonic acid transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOAT"]}, "metabolites": {"kdolipid4_c": 1.0, "lipidA_c": -1.0, "ckdo_c": -1.0, "h_c": 1.0, "cmp_c": 1.0}, "id": "MOAT", "gene_reaction_rule": "c4457"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "3-deoxy-D-manno-octulosonic acid transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOAT2"]}, "metabolites": {"kdo2lipid4_c": 1.0, "kdolipid4_c": -1.0, "cmp_c": 1.0, "h_c": 1.0, "ckdo_c": -1.0}, "id": "MOAT2", "gene_reaction_rule": "c4457"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Molybdate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOBDabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "mobd_c": 1.0, "mobd_p": -1.0, "adp_c": 1.0, "pi_c": 1.0, "h_c": 1.0}, "id": "MOBDabcpp", "gene_reaction_rule": "(c0840 and c0841 and c0842) or (c2956 and c2958 and c2957 and c4869) or (c2956 and c2958 and c2957)"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Molybdate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MOBDtex"]}, "metabolites": {"mobd_e": -1.0, "mobd_p": 1.0}, "id": "MOBDtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Molybdopterin cytidine dinucleotide synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOCDS"]}, "metabolites": {"ctp_c": -1.0, "mococdp_c": 1.0, "ppi_c": 1.0, "moco_c": -1.0, "h_c": -1.0}, "id": "MOCDS", "gene_reaction_rule": "c3455"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Molybdenum cofactor synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOCOS"]}, "metabolites": {"cu2_c": 1.0, "h2o_c": 1.0, "mobd_c": -1.0, "moco_c": 1.0, "h_c": -2.0, "mptamp_c": -1.0, "amp_c": 1.0}, "id": "MOCOS", "gene_reaction_rule": "c0912"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Molybdopterin guanine dinucleotide synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOGDS"]}, "metabolites": {"ppi_c": 1.0, "gtp_c": -1.0, "moco_c": -1.0, "mocogdp_c": 1.0, "h_c": -1.0}, "id": "MOGDS", "gene_reaction_rule": "c4801 or (c4801 and c4800)"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "3-methyl-2-oxobutanoate hydroxymethyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MOHMT"]}, "metabolites": {"h2o_c": -1.0, "2dhp_c": 1.0, "thf_c": 1.0, "mlthf_c": -1.0, "3mob_c": -1.0}, "id": "MOHMT", "gene_reaction_rule": "c0165"}, {"subsystem": "Citric Acid Cycle", "name": "Malate oxidase", "upper_bound": 1000.0, "lower_bound": -1000.0, 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semialdehyde reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MSAR"]}, "metabolites": {"3hpp_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "msa_c": -1.0}, "id": "MSAR", "gene_reaction_rule": "c1145 or c1965"}, {"subsystem": "Transport, Inner Membrane", "name": "Methanesulfonate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MSO3abcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "mso3_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "mso3_p": -1.0}, "id": "MSO3abcpp", "gene_reaction_rule": "c1079 and c1076 and c1077"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Methanesulfonate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MSO3tex"]}, "metabolites": {"mso3_e": -1.0, "mso3_p": 1.0}, "id": "MSO3tex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Arginine and Proline Metabolism", "name": "Methylthioadenosine nucleosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MTAN"]}, "metabolites": {"5mtr_c": 1.0, "h2o_c": -1.0, "5mta_c": -1.0, "ade_c": 1.0}, "id": "MTAN", "gene_reaction_rule": "c0195"}, {"subsystem": "Folate Metabolism", "name": "Methenyltetrahydrofolate cyclohydrolase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MTHFC"]}, "metabolites": {"h2o_c": -1.0, "10fthf_c": 1.0, "methf_c": -1.0, "h_c": 1.0}, "id": "MTHFC", "gene_reaction_rule": "c0645"}, {"subsystem": "Folate Metabolism", "name": "Methylenetetrahydrofolate dehydrogenase (NADP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["MTHFD"]}, "metabolites": {"nadp_c": -1.0, "nadph_c": 1.0, "methf_c": 1.0, "mlthf_c": -1.0}, "id": "MTHFD", "gene_reaction_rule": "c0645"}, {"subsystem": "Folate Metabolism", "name": "5,10-methylenetetrahydrofolate reductase (NADH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MTHFR2"]}, "metabolites": {"mlthf_c": -1.0, "nadh_c": -1.0, "5mthf_c": 1.0, "nad_c": 1.0, "h_c": -2.0}, "id": "MTHFR2", "gene_reaction_rule": "c4899"}, {"subsystem": "Methionine Metabolism", "name": "(2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran synthesis (spontaneous)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MTHTHFSs"]}, "metabolites": {"h2o_c": -1.0, "mththf_c": 1.0, "mdhdhf_c": -1.0}, "id": "MTHTHFSs", "gene_reaction_rule": "s0001"}, {"subsystem": "Glycine and Serine Metabolism", "name": "N-methyltryptophan oxidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MTRPOX"]}, "metabolites": {"o2_c": -1.0, "h2o_c": -1.0, "Nmtrp_c": -1.0, "fald_c": 1.0, "h2o2_c": 1.0, "trp__L_c": 1.0}, "id": "MTRPOX", "gene_reaction_rule": "c1326"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Nitrious oxide transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["N2Otex"]}, "metabolites": {"n2o_p": 1.0, "n2o_e": -1.0}, "id": "N2Otex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Nitrious oxide transport (diffusion)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["N2Otpp"]}, "metabolites": {"n2o_c": 1.0, "n2o_p": -1.0}, "id": "N2Otpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Arginine and Proline Metabolism", "name": "N-acetylornithine deacetylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACODA"]}, "metabolites": {"glu5sa_c": 1.0, "h2o_c": -1.0, "ac_c": 1.0, "acg5sa_c": -1.0}, "id": "NACODA", "gene_reaction_rule": "c4916"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Nicotinic acid transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NACtex"]}, "metabolites": {"nac_e": -1.0, "nac_p": 1.0}, "id": "NACtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Transport, Inner Membrane", "name": "Nicotinic acid uptake (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NACtpp"]}, "metabolites": {"nac_c": 1.0, "nac_p": -1.0}, "id": "NACtpp", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NAD diphosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADDP"]}, "metabolites": {"h2o_c": -1.0, "nmn_c": 1.0, "h_c": 2.0, "nad_c": -1.0, "amp_c": 1.0}, "id": "NADDP", "gene_reaction_rule": "c4953 or c2945"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (menaquinone-8 & 0 protons)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH10"]}, "metabolites": {"nadh_c": -1.0, "mqn8_c": -1.0, "mql8_c": 1.0, "nad_c": 1.0, "h_c": -1.0}, "id": "NADH10", "gene_reaction_rule": "c1382"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (ubiquinone-8 & 3 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH16pp"]}, "metabolites": {"h_p": 3.0, "q8h2_c": 1.0, "h_c": -4.0, "nad_c": 1.0, "nadh_c": -1.0, "q8_c": -1.0}, "id": "NADH16pp", "gene_reaction_rule": "c2817 and c2818 and c2819 and c2820 and c2821 and c2822 and c2823 and c2824 and c2825 and c2826 and c2827 and c2828 and c2829"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (menaquinone-8 & 3 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH17pp"]}, "metabolites": {"mqn8_c": -1.0, "h_p": 3.0, "h_c": -4.0, "nad_c": 1.0, "nadh_c": -1.0, "mql8_c": 1.0}, "id": "NADH17pp", "gene_reaction_rule": "c2817 and c2818 and c2819 and c2820 and c2821 and c2822 and c2823 and c2824 and c2825 and c2826 and c2827 and c2828 and c2829"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (demethylmenaquinone-8 & 3 protons) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH18pp"]}, "metabolites": {"2dmmq8_c": -1.0, "h_p": 3.0, "2dmmql8_c": 1.0, "h_c": -4.0, "nad_c": 1.0, "nadh_c": -1.0}, "id": "NADH18pp", "gene_reaction_rule": "c2817 and c2818 and c2819 and c2820 and c2821 and c2822 and c2823 and c2824 and c2825 and c2826 and c2827 and c2828 and c2829"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (ubiquinone-8 )", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH5"]}, "metabolites": {"q8h2_c": 1.0, "nadh_c": -1.0, "q8_c": -1.0, "nad_c": 1.0, "h_c": -1.0}, "id": "NADH5", "gene_reaction_rule": "c1382"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADH dehydrogenase (demethylmenaquinone-8 & 0 protons)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADH9"]}, "metabolites": {"nadh_c": -1.0, "2dmmql8_c": 1.0, "2dmmq8_c": -1.0, "nad_c": 1.0, "h_c": -1.0}, "id": "NADH9", "gene_reaction_rule": "c1382"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NAD kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADK"]}, "metabolites": {"adp_c": 1.0, "nadp_c": 1.0, "nad_c": -1.0, "atp_c": -1.0, "h_c": 1.0}, "id": "NADK", "gene_reaction_rule": "c3137"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NAD nucleosidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADN"]}, "metabolites": {"h_c": 1.0, "h2o_c": -1.0, "nad_c": -1.0, "adprib_c": 1.0, "ncam_c": 1.0}, "id": "NADN", "gene_reaction_rule": ""}, {"subsystem": "Oxidative Phosphorylation", "name": "NADPH Quinone Reductase (Ubiquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPHQR2"]}, "metabolites": {"q8h2_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "h_c": -1.0, "q8_c": -1.0}, "id": "NADPHQR2", "gene_reaction_rule": "c3768"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADPH Quinone Reductase (Menaquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPHQR3"]}, "metabolites": {"nadph_c": -1.0, "nadp_c": 1.0, "mqn8_c": -1.0, "h_c": -1.0, "mql8_c": 1.0}, "id": "NADPHQR3", "gene_reaction_rule": "c3768"}, {"subsystem": "Oxidative Phosphorylation", "name": "NADPH Quinone Reductase (2-Demethylmenaquinone-8)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPHQR4"]}, "metabolites": {"nadp_c": 1.0, "nadph_c": -1.0, "2dmmq8_c": -1.0, "2dmmql8_c": 1.0, "h_c": -1.0}, "id": "NADPHQR4", "gene_reaction_rule": "c3768"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NADP phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADPPPS"]}, "metabolites": {"h2o_c": -1.0, "nadp_c": -1.0, "pi_c": 1.0, "nad_c": 1.0}, "id": "NADPPPS", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "NAD synthase (nh3)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADS1"]}, "metabolites": {"dnad_c": -1.0, "atp_c": -1.0, "ppi_c": 1.0, "amp_c": 1.0, "nad_c": 1.0, "nh4_c": -1.0, "h_c": 1.0}, "id": "NADS1", "gene_reaction_rule": "c2139"}, {"subsystem": "Oxidative Phosphorylation", "name": "NAD transhydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NADTRHD"]}, "metabolites": {"nadp_c": 1.0, "nadph_c": -1.0, "nadh_c": 1.0, "nad_c": -1.0}, "id": "NADTRHD", "gene_reaction_rule": "c4923 or (c1994 and c1995)"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Nicotinic acid mononucleotide pyrophosphorylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NAMNPP"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "nicrnt_c": 1.0, 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"metabolites": {"na1_p": 1.0, "na1_c": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "NAt3pp", "gene_reaction_rule": "c0927 or c1676"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Sodium transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NAtex"]}, "metabolites": {"na1_p": 1.0, "na1_e": -1.0}, "id": "NAtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:GDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK1"]}, "metabolites": {"gtp_c": 1.0, "gdp_c": -1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "NDPK1", "gene_reaction_rule": "c0594 or c3041"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Nucleoside-diphosphate kinase (ATP:UDP)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NDPK2"]}, "metabolites": {"udp_c": -1.0, "utp_c": 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["NOVBCNtpp"]}, "metabolites": {"novbcn_e": 1.0, "h_c": 1.0, "h_p": -1.0, "novbcn_p": -1.0}, "id": "NOVBCNtpp", "gene_reaction_rule": "c0581 and c2997 and c3781"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Nitric oxide transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NOtex"]}, "metabolites": {"no_e": -1.0, "no_p": 1.0}, "id": "NOtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "NO transport (diffusion)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["NOtpp"]}, "metabolites": {"no_p": -1.0, "no_c": 1.0}, "id": "NOtpp", "gene_reaction_rule": "s0001"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "5'-nucleotidase (dUMP)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["NTD1"]}, "metabolites": {"h2o_c": -1.0, "pi_c": 1.0, "dump_c": -1.0, 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"Glycerophospholipid Metabolism", "name": "Phospholipase A2 (phosphatidylglycerol, n-C14:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PLIPA2G140pp"]}, "metabolites": {"h2o_p": -1.0, "pg140_p": -1.0, "1agpg140_p": 1.0, "ttdca_p": 1.0, "h_p": 1.0}, "id": "PLIPA2G140pp", "gene_reaction_rule": "c4742"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phospholipase A2 (phosphatidylglycerol, n-C14:1) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PLIPA2G141pp"]}, "metabolites": {"h2o_p": -1.0, "pg141_p": -1.0, "ttdcea_p": 1.0, "1agpg141_p": 1.0, "h_p": 1.0}, "id": "PLIPA2G141pp", "gene_reaction_rule": "c4742"}, {"subsystem": "Glycerophospholipid Metabolism", "name": "Phospholipase A2 (phosphatidylglycerol, n-C16:0) (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PLIPA2G160pp"]}, "metabolites": {"pg160_p": -1.0, "h2o_p": -1.0, "1agpg160_p": 1.0, "h_p": 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["PLIPA2G181pp"]}, "metabolites": {"h2o_p": -1.0, "1agpg181_p": 1.0, "ocdcea_p": 1.0, "h_p": 1.0, "pg181_p": -1.0}, "id": "PLIPA2G181pp", "gene_reaction_rule": "c4742"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Phosphomannomutase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PMANM"]}, "metabolites": {"man1p_c": -1.0, "man6p_c": 1.0}, "id": "PMANM", "gene_reaction_rule": "c2573"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Pyrimidine phosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PMDPHT"]}, "metabolites": {"4r5au_c": 1.0, "h2o_c": -1.0, "pi_c": 1.0, "5aprbu_c": -1.0}, "id": "PMDPHT", "gene_reaction_rule": ""}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Pimeloyl-[ACP] methyl ester esterase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PMEACPE"]}, "metabolites": {"pmeACP_c": -1.0, "h2o_c": -1.0, "pimACP_c": 1.0, 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"c4023"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Pantothenate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PNTOtex"]}, "metabolites": {"pnto__R_e": -1.0, "pnto__R_p": 1.0}, "id": "PNTOtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Peroxyaminoacrylate reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["POAACR"]}, "metabolites": {"3amac_c": 1.0, "h2o_c": 1.0, "nadh_c": -1.0, "poaac_c": -1.0, "nad_c": 1.0}, "id": "POAACR", "gene_reaction_rule": "c1147"}, {"subsystem": "Pyruvate Metabolism", "name": "Pyruvate synthase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["POR5"]}, "metabolites": {"flxso_c": -2.0, "pyr_c": -1.0, "flxr_c": 2.0, "coa_c": -1.0, "h_c": 1.0, "accoa_c": 1.0, "co2_c": 1.0}, "id": "POR5", "gene_reaction_rule": "(c0771 and c1823) or (c3475 and c1823)"}, {"subsystem": "Oxidative Phosphorylation", "name": "Pyruvate oxidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["POX"]}, "metabolites": {"h2o_c": -1.0, "q8h2_c": 1.0, "pyr_c": -1.0, "ac_c": 1.0, "co2_c": 1.0, "q8_c": -1.0}, "id": "POX", "gene_reaction_rule": "c1004"}, {"subsystem": "Anaplerotic Reactions", "name": "Inorganic diphosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPA"]}, "metabolites": {"ppi_c": -1.0, "pi_c": 2.0, "h_c": 1.0, "h2o_c": -1.0}, "id": "PPA", "gene_reaction_rule": "c3311 or c5323 or c3020"}, {"subsystem": "Anaplerotic Reactions", "name": "Inorganic triphosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPA2"]}, "metabolites": {"pppi_c": -1.0, "ppi_c": 1.0, "pi_c": 1.0, "h2o_c": -1.0, "h_c": 1.0}, "id": "PPA2", "gene_reaction_rule": "c3020 or c3311"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Propionate kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PPAKr"]}, "metabolites": {"ppa_c": 1.0, "atp_c": 1.0, "adp_c": -1.0, "ppap_c": -1.0}, "id": "PPAKr", "gene_reaction_rule": "c4530"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Propanal transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PPALtex"]}, "metabolites": {"ppal_p": 1.0, "ppal_e": -1.0}, "id": "PPALtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Transport, Inner Membrane", "name": "Propanal transport via channel (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PPALtpp"]}, "metabolites": {"ppal_p": 1.0, "ppal_c": -1.0}, "id": "PPALtpp", "gene_reaction_rule": ""}, {"subsystem": "Transport, Inner Membrane", "name": "Na+/Propionate symporter (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": 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"h_c": 1.0, "oaa_c": 1.0, "co2_c": -1.0}, "id": "PPC", "gene_reaction_rule": "c4915"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Phosphopantothenoylcysteine decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPCDC"]}, "metabolites": {"pan4p_c": 1.0, "co2_c": 1.0, "4ppcys_c": -1.0, "h_c": -1.0}, "id": "PPCDC", "gene_reaction_rule": "c4463"}, {"subsystem": "Anaplerotic Reactions", "name": "Phosphoenolpyruvate carboxykinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPCK"]}, "metabolites": {"pep_c": 1.0, "co2_c": 1.0, "oaa_c": -1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "PPCK", "gene_reaction_rule": "c4176"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Propanoyl-CoA: succinate CoA-transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPCSCT"]}, "metabolites": {"succ_c": -1.0, "succoa_c": 1.0, "ppa_c": 1.0, "ppcoa_c": -1.0}, "id": "PPCSCT", "gene_reaction_rule": "c3498"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPGPPDP"]}, "metabolites": {"ppgpp_c": -1.0, "gdp_c": 1.0, "ppi_c": 1.0, "h2o_c": -1.0}, "id": "PPGPPDP", "gene_reaction_rule": "c4475"}, {"subsystem": "Oxidative Phosphorylation", "name": "Polyphosphate kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PPK2r"]}, "metabolites": {"pppi_c": 1.0, "ppi_c": -1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "PPK2r", "gene_reaction_rule": "c3019"}, {"subsystem": "Oxidative Phosphorylation", "name": "Polyphosphate kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PPKr"]}, "metabolites": {"ppi_c": 1.0, "pi_c": -1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "PPKr", "gene_reaction_rule": "c3019"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Phosphopentomutase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PPM"]}, "metabolites": {"r5p_c": 1.0, "r1p_c": -1.0}, "id": "PPM", "gene_reaction_rule": "c4150 or c5467"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Phosphopentomutase 2 (deoxyribose)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PPM2"]}, "metabolites": {"2dr1p_c": -1.0, "2dr5p_c": 1.0}, "id": "PPM2", "gene_reaction_rule": "c5467"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Phosphopantothenate-cysteine ligase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPNCL2"]}, "metabolites": {"cys__L_c": -1.0, "cmp_c": 1.0, "ppi_c": 1.0, "4ppcys_c": 1.0, "4ppan_c": -1.0, "h_c": 1.0, "ctp_c": -1.0}, "id": "PPNCL2", "gene_reaction_rule": "c4463"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Prephenate dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, 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"notes": {"original_bigg_ids": ["THRA2i"]}, "metabolites": {"acald_c": 1.0, "gly_c": 1.0, "athr__L_c": -1.0}, "id": "THRA2i", "gene_reaction_rule": "c3073 or c1003"}, {"subsystem": "Threonine and Lysine Metabolism", "name": "Threonine aldolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THRAi"]}, "metabolites": {"acald_c": 1.0, "thr__L_c": -1.0, "gly_c": 1.0}, "id": "THRAi", "gene_reaction_rule": "c3073 or c1003"}, {"subsystem": "Glycine and Serine Metabolism", "name": "L-threonine dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THRD"]}, "metabolites": {"thr__L_c": -1.0, "nadh_c": 1.0, "2aobut_c": 1.0, "nad_c": -1.0, "h_c": 1.0}, "id": "THRD", "gene_reaction_rule": "c4443"}, {"subsystem": "Valine, Leucine, and Isoleucine Metabolism", "name": "L-threonine deaminase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THRD_L"]}, "metabolites": {"thr__L_c": -1.0, "2obut_c": 1.0, "nh4_c": 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Membrane Porin", "name": "Trehalose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TREtex"]}, "metabolites": {"tre_p": 1.0, "tre_e": -1.0}, "id": "TREtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Tryptophanase (L-tryptophan)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TRPAS2"]}, "metabolites": {"h2o_c": -1.0, "pyr_c": 1.0, "nh4_c": 1.0, "trp__L_c": -1.0, "indole_c": 1.0}, "id": "TRPAS2", "gene_reaction_rule": "c4631"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Tryptophan synthase (indoleglycerol phosphate)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRPS1"]}, "metabolites": {"ser__L_c": -1.0, "3ig3p_c": -1.0, "h2o_c": 1.0, "trp__L_c": 1.0, "g3p_c": 1.0}, "id": "TRPS1", "gene_reaction_rule": "c1725 and c1726"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Tryptophan synthase (indole)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRPS2"]}, "metabolites": {"ser__L_c": -1.0, "h2o_c": 1.0, "trp__L_c": 1.0, "indole_c": -1.0}, "id": "TRPS2", "gene_reaction_rule": "c1725 and c1726"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Tryptophan synthase (indoleglycerol phosphate)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRPS3"]}, "metabolites": {"3ig3p_c": -1.0, "g3p_c": 1.0, "indole_c": 1.0}, "id": "TRPS3", "gene_reaction_rule": "c1725 and c1726"}, {"subsystem": "tRNA Charging", "name": "Tryptophanyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TRPTRS"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "trnatrp_c": -1.0, "amp_c": 1.0, "trptrna_c": 1.0, "trp__L_c": -1.0}, "id": "TRPTRS", "gene_reaction_rule": "c4154"}, {"subsystem": "Transport, Inner Membrane", "name": "L-tryptophan reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TRPt2rpp"]}, "metabolites": {"trp__L_c": 1.0, "h_c": 1.0, "h_p": -1.0, "trp__L_p": -1.0}, "id": "TRPt2rpp", "gene_reaction_rule": "c3914 or c4632 or c1902 or c0131"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-tryptophan transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TRPtex"]}, "metabolites": {"trp__L_e": -1.0, "trp__L_p": 1.0}, "id": "TRPtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Tartronate semialdehyde reductase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TRSARr"]}, "metabolites": {"nadh_c": -1.0, "glyc__R_c": 1.0, "2h3oppan_c": -1.0, "nad_c": 1.0, "h_c": -1.0}, "id": "TRSARr", "gene_reaction_rule": "c0624 or c3880"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Thiosulfate transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TSULabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "tsul_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "tsul_c": 1.0}, "id": "TSULabcpp", "gene_reaction_rule": "(c2956 and c2959 and c2958 and c2957) or (c2956 and c2958 and c2957 and c4869)"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Thiosulfate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TSULtex"]}, "metabolites": {"tsul_e": -1.0, "tsul_p": 1.0}, "id": "TSULtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Transport, Outer Membrane", "name": "Tetradecanoate transport via facilitated irreversible diffusion (extracellular to periplasm)", 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Porin", "name": "Tyramine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TYMtex"]}, "metabolites": {"tym_e": -1.0, "tym_p": 1.0}, "id": "TYMtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Tyrosine lyase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TYRL"]}, "metabolites": {"nadp_c": 1.0, "nadph_c": -1.0, "dad_5_c": 1.0, "dhgly_c": 1.0, "tyr__L_c": -1.0, "h_c": 1.0, "met__L_c": 1.0, "4crsol_c": 1.0, "amet_c": -1.0}, "id": "TYRL", "gene_reaction_rule": "c4947"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Phospho-L-tyrosine phosphatase (periplasmic)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TYRPpp"]}, "metabolites": {"pi_p": 1.0, "tyrp_p": -1.0, "tyr__L_p": 1.0, "h2o_p": -1.0}, "id": "TYRPpp", "gene_reaction_rule": "c5045"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Phopho-L-tyrosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TYRPtex"]}, "metabolites": {"tyrp_p": 1.0, "tyrp_e": -1.0}, "id": "TYRPtex", "gene_reaction_rule": "c2758 or c0388 or c1071 or c1822"}, {"subsystem": "Tyrosine, Tryptophan, and Phenylalanine Metabolism", "name": "Tyrosine transaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TYRTA"]}, "metabolites": {"akg_c": -1.0, "34hpp_c": 1.0, "glu__L_c": 1.0, "tyr__L_c": -1.0}, "id": "TYRTA", "gene_reaction_rule": "c5031 or c1070"}, {"subsystem": "tRNA Charging", "name": "Tyrosyl-tRNA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TYRTRS"]}, "metabolites": {"atp_c": -1.0, "ppi_c": 1.0, "tyrtrna_c": 1.0, "trnatyr_c": -1.0, "amp_c": 1.0, "tyr__L_c": -1.0}, "id": "TYRTRS", "gene_reaction_rule": "c2029"}, {"subsystem": "Transport, Inner Membrane", "name": "L-tyrosine reversible transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TYRt2rpp"]}, "metabolites": {"tyr__L_p": -1.0, "h_c": 1.0, "h_p": -1.0, "tyr__L_c": 1.0}, "id": "TYRt2rpp", "gene_reaction_rule": "c1902 or c2323 or c0131 or c0662"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-tyrosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TYRtex"]}, "metabolites": {"tyr__L_e": -1.0, "tyr__L_p": 1.0}, "id": "TYRtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "ThDP adenylyl transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ThDPAT"]}, "metabolites": {"thmpp_c": -1.0, "athtp_c": 1.0, "pi_c": 1.0, "h_c": -1.0, "adp_c": -1.0}, "id": "ThDPAT", "gene_reaction_rule": ""}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "UDP-3-O-(3-hydroxymyristoyl)glucosamine acyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["U23GAAT"]}, "metabolites": {"h_c": 1.0, "u23ga_c": 1.0, "ACP_c": 1.0, "3hmrsACP_c": -1.0, "u3hga_c": -1.0}, "id": "U23GAAT", "gene_reaction_rule": "c0216"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UAAGDS"]}, "metabolites": {"atp_c": -1.0, "26dap__M_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "uamag_c": -1.0, "ugmd_c": 1.0}, "id": "UAAGDS", "gene_reaction_rule": "c0103"}, {"subsystem": "Alternate Carbon Metabolism", "name": "UDP-N-acetyl-D-galactosamine pyrophosphohydrolase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UACGALPpp"]}, 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"name": "Undecaprenyl phosphate transport (cytoplasm to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UDCPPtppi"]}, "metabolites": {"udcpp_p": -1.0, "udcpp_c": 1.0}, "id": "UDCPPtppi", "gene_reaction_rule": ""}, {"subsystem": "Transport, Outer Membrane Porin", "name": "UDP-N-acetyl-D-galactosamine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UDPACGALtex"]}, "metabolites": {"udpacgal_e": -1.0, "udpacgal_p": 1.0}, "id": "UDPACGALtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Alternate Carbon Metabolism", "name": "UDPglucose 4-epimerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UDPG4E"]}, "metabolites": {"udpgal_c": 1.0, "udpg_c": -1.0}, "id": "UDPG4E", "gene_reaction_rule": "c0835"}, {"subsystem": "Alternate Carbon Metabolism", "name": "UDPgalactose pyrophosphohydrolase", 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decarboxylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UDPGDC"]}, "metabolites": {"udpglcur_c": -1.0, "co2_c": 1.0, "udpLa4o_c": 1.0, "nadh_c": 1.0, "nad_c": -1.0}, "id": "UDPGDC", "gene_reaction_rule": "c2797"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "UDP-D-glucuronate transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UDPGLCURtex"]}, "metabolites": {"udpglcur_e": -1.0, "udpglcur_p": 1.0}, "id": "UDPGLCURtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Alternate Carbon Metabolism", "name": "UDPglucose pyrophosphohydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UDPGPpp"]}, "metabolites": {"h2o_p": -1.0, "ump_p": 1.0, "g1p_p": 1.0, "h_p": 2.0, "udpg_p": -1.0}, "id": "UDPGPpp", "gene_reaction_rule": "c0600"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "UDPglucose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UDPGtex"]}, "metabolites": {"udpg_e": -1.0, "udpg_p": 1.0}, "id": "UDPGtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "UDP-4''-ketopentose:UDP-4-amino-4-deoxy-L-arabinose aminotransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UDPKAAT"]}, "metabolites": {"akg_c": 1.0, "glu__L_c": -1.0, "udpLa4o_c": -1.0, "udpLa4n_c": 1.0}, "id": "UDPKAAT", "gene_reaction_rule": "c2795"}, {"subsystem": "Alternate Carbon Metabolism", "name": "UDP-D-glucuronate pyrophosphohydrolase (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UGLCURPpp"]}, "metabolites": {"h2o_p": -1.0, "glcur1p_p": 1.0, "ump_p": 1.0, "h_p": 2.0, "udpglcur_p": -1.0}, "id": "UGLCURPpp", "gene_reaction_rule": "c0600"}, {"subsystem": "Alternate Carbon Metabolism", "name": "UDPglucose--hexose-1-phosphate uridylyltransferase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UGLT"]}, "metabolites": {"udpgal_c": 1.0, "udpg_c": -1.0, "gal1p_c": -1.0, "g1p_c": 1.0}, "id": "UGLT", "gene_reaction_rule": "c0834"}, {"subsystem": "Nitrogen Metabolism", "name": "Ureidoglycolate hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UGLYCH"]}, "metabolites": {"urdglyc_c": -1.0, "h2o_c": -1.0, "glx_c": 1.0, "h_c": -2.0, "co2_c": 1.0, "nh4_c": 2.0}, "id": "UGLYCH", "gene_reaction_rule": "c0620"}, {"subsystem": "Cell Envelope Biosynthesis", "name": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UGMDDS"]}, "metabolites": {"atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "ugmda_c": 1.0, "pi_c": 1.0, "alaala_c": -1.0, "ugmd_c": -1.0}, "id": "UGMDDS", "gene_reaction_rule": "c0104"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "UDP-3-O-acetylglucosamine deacetylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UHGADA"]}, "metabolites": {"u3aga_c": -1.0, "u3hga_c": 1.0, "h2o_c": -1.0, "ac_c": 1.0}, "id": "UHGADA", "gene_reaction_rule": "c0114"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "UDP-L-Ara4N formyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ULA4NFT"]}, "metabolites": {"h_c": 1.0, "udpLa4fn_c": 1.0, "udpLa4n_c": -1.0, "thf_c": 1.0, "10fthf_c": -1.0}, "id": "ULA4NFT", "gene_reaction_rule": "c2797"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Transport (cytoplasm to periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ULA4Ntppi"]}, "metabolites": {"uLa4n_p": 1.0, "uLa4n_c": -1.0}, "id": "ULA4Ntppi", "gene_reaction_rule": "c2800 and c2801"}, {"subsystem": "Murein Recycling", "name": "UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UM3PL"]}, "metabolites": {"LalaDgluMdap_c": -1.0, "atp_c": -1.0, "uamr_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "ugmd_c": 1.0}, "id": "UM3PL", "gene_reaction_rule": "c5331"}, {"subsystem": "Murein Recycling", "name": "UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate-D-alanine L,D-carboxypeptidase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UM4PCP"]}, "metabolites": {"h2o_c": -1.0, "ala__D_c": 1.0, "um4p_c": -1.0, "ugmd_c": 1.0}, "id": "UM4PCP", "gene_reaction_rule": "c1641"}, {"subsystem": "Murein Recycling", "name": "UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate-D-alanine ligase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UM4PL"]}, "metabolites": {"LalaDgluMdapDala_c": -1.0, "atp_c": -1.0, "uamr_c": -1.0, "um4p_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "UM4PL", "gene_reaction_rule": "c5331"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "UMP kinase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UMPK"]}, "metabolites": {"ump_c": -1.0, "udp_c": 1.0, "adp_c": 1.0, "atp_c": -1.0}, "id": "UMPK", "gene_reaction_rule": "c1048 or c0207"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "UMP transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["UMPtex"]}, "metabolites": {"ump_p": 1.0, "ump_e": -1.0}, "id": "UMPtex", "gene_reaction_rule": "c1071 or c1822 or c2758 or c0388"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Undecaprenyl phosphate-L-Ara4FN formylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UPLA4FNF"]}, "metabolites": {"h2o_c": -1.0, "for_c": 1.0, "uLa4fn_c": -1.0, "uLa4n_c": 1.0}, "id": "UPLA4FNF", "gene_reaction_rule": "c2798"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "Undecaprenyl phosphate-L-Ara4FN transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UPLA4FNT"]}, "metabolites": {"udpLa4fn_c": -1.0, "udp_c": 1.0, "uLa4fn_c": 1.0, "udcpp_c": -1.0}, "id": "UPLA4FNT", "gene_reaction_rule": "c2796"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Uroporphyrinogen methyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UPP3MT"]}, "metabolites": {"amet_c": -2.0, "dscl_c": 1.0, "ahcys_c": 2.0, "h_c": 1.0, "uppg3_c": -1.0}, "id": "UPP3MT", "gene_reaction_rule": "c4722 or c4144"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Uroporphyrinogen-III synthase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UPP3S"]}, "metabolites": {"h2o_c": 1.0, "hmbil_c": -1.0, "uppg3_c": 1.0}, "id": "UPP3S", "gene_reaction_rule": "c4723"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Uroporphyrinogen decarboxylase (uroporphyrinogen III)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UPPDC1"]}, "metabolites": {"co2_c": 4.0, "h_c": -4.0, "uppg3_c": -1.0, "cpppg3_c": 1.0}, "id": "UPPDC1", "gene_reaction_rule": "c4954"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Uracil phosphoribosyltransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UPPRT"]}, "metabolites": {"ump_c": 1.0, "ppi_c": 1.0, "prpp_c": -1.0, "ura_c": -1.0}, "id": "UPPRT", "gene_reaction_rule": "c3015"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Peroxyureidoacrylate hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["URACPAH"]}, "metabolites": {"h_c": 1.0, "h2o_c": -1.0, "poaac_c": 1.0, "uracp_c": -1.0, "cbm_c": 1.0}, "id": "URACPAH", "gene_reaction_rule": "c1148"}, {"subsystem": "Transport, Inner Membrane", "name": "Uracil transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["URAt2pp", "URAt2rpp"]}, "metabolites": {"ura_c": 1.0, "ura_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "URAt2pp_copy1", "gene_reaction_rule": "c3014"}, {"subsystem": "Transport, Inner Membrane", "name": "Uracil transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["URAt2pp", "URAt2rpp"]}, "metabolites": {"ura_c": 1.0, "ura_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "URAt2pp_copy2", "gene_reaction_rule": "c1143"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Uracil transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["URAtex"]}, "metabolites": {"ura_p": 1.0, "ura_e": -1.0}, "id": "URAtex", "gene_reaction_rule": "c0388 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"Unassigned", "name": "Uricase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["URIC"]}, "metabolites": {"o2_c": -1.0, "h2o_c": -2.0, "urate_c": -1.0, "h2o2_c": 1.0, "co2_c": 1.0, "alltn_c": 1.0}, "id": "URIC", "gene_reaction_rule": ""}, {"subsystem": "Alternate Carbon Metabolism", "name": "Uridine hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["URIH"]}, "metabolites": {"uri_c": -1.0, "h2o_c": -1.0, "rib__D_c": 1.0, "ura_c": 1.0}, "id": "URIH", "gene_reaction_rule": "c2696 or c0735 or rihC"}, {"subsystem": "Nucleotide Salvage Pathway", "name": "Uridine kinase (GTP:Uridine)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["URIK2"]}, "metabolites": {"ump_c": 1.0, "gtp_c": -1.0, "gdp_c": 1.0, "h_c": 1.0, "uri_c": -1.0}, "id": "URIK2", "gene_reaction_rule": "c2593"}, {"subsystem": "Transport, Inner Membrane", "name": "Uridine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["URIt2pp", "URIt2rpp"]}, "metabolites": {"uri_c": 1.0, "uri_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "URIt2pp_copy1", "gene_reaction_rule": "c2932 or c3552"}, {"subsystem": "Transport, Inner Membrane", "name": "Uridine transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["URIt2pp", "URIt2rpp"]}, "metabolites": {"uri_c": 1.0, "uri_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "URIt2pp_copy2", "gene_reaction_rule": "c2939"}, {"subsystem": "Transport, Outer Membrane", "name": "Uridine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["URItex"]}, "metabolites": {"uri_p": 1.0, "uri_e": -1.0}, "id": "URItex", "gene_reaction_rule": "c0521"}, {"subsystem": "Lipopolysaccharide Biosynthesis / Recycling", "name": "UDP-sugar hydrolase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": 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"xan_c": 1.0, "xtsn_c": -1.0}, "id": "XTSNH", "gene_reaction_rule": "rihC"}, {"subsystem": "Transport, Inner Membrane", "name": "Xanthosine transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XTSNt2rpp"]}, "metabolites": {"xtsn_p": -1.0, "h_c": 1.0, "h_p": -1.0, "xtsn_c": 1.0}, "id": "XTSNt2rpp", "gene_reaction_rule": "c2939"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Xanthosine transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XTSNtex"]}, "metabolites": {"xtsn_e": -1.0, "xtsn_p": 1.0}, "id": "XTSNtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Xylose isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XYLI1"]}, "metabolites": {"xylu__D_c": 1.0, "xyl__D_c": -1.0}, "id": "XYLI1", "gene_reaction_rule": "c4385"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Xylose isomerase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XYLI2"]}, "metabolites": {"glc__D_c": -1.0, "fru_c": 1.0}, "id": "XYLI2", "gene_reaction_rule": "c4385"}, {"subsystem": "Alternate Carbon Metabolism", "name": "Xylulokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["XYLK"]}, "metabolites": {"xylu__D_c": -1.0, "xu5p__D_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "XYLK", "gene_reaction_rule": "c0075 or c4384"}, {"subsystem": "Alternate Carbon Metabolism", "name": "L-xylulokinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["XYLK2"]}, "metabolites": {"xylu__L_c": -1.0, "xu5p__L_c": 1.0, "h_c": 1.0, "atp_c": -1.0, "adp_c": 1.0}, "id": "XYLK2", "gene_reaction_rule": "c0075 or c4403"}, {"subsystem": "Transport, Inner Membrane", "name": "L-xylulose transport in via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["XYLUt2pp"]}, "metabolites": {"xylu__L_c": 1.0, "xylu__L_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "XYLUt2pp", "gene_reaction_rule": "c4399 and c4400 and c4402"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "L-xylulose transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["XYLUtex"]}, "metabolites": {"xylu__L_p": 1.0, "xylu__L_e": -1.0}, "id": "XYLUtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "Transport, Inner Membrane", "name": "D-xylose transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["XYLabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "xyl__D_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "xyl__D_c": 1.0}, "id": "XYLabcpp", "gene_reaction_rule": "c4386 and c4387 and c4388"}, {"subsystem": "Transport, Outer 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"c4866 or c0827"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Zinc transport in via permease (no H+)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ZN2tpp"]}, "metabolites": {"zn2_c": 1.0, "zn2_p": -1.0}, "id": "ZN2tpp", "gene_reaction_rule": "c3789"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Zinc (Zn+2) transport via ABC system (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ZNabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "zn2_p": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "zn2_c": 1.0}, "id": "ZNabcpp", "gene_reaction_rule": "c2271 and c2273 and c2272"}, {"subsystem": "Transport, Outer Membrane Porin", "name": "Zinc (Zn+2) transport via diffusion (extracellular to periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["Zn2tex"]}, "metabolites": {"zn2_e": -1.0, "zn2_p": 1.0}, "id": "Zn2tex", "gene_reaction_rule": "c0388 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exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_4abz_LPAREN_e_RPAREN_"]}, "metabolites": {"4abz_e": -1.0}, "id": "EX_4abz_e", "gene_reaction_rule": ""}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxooctanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HACD3i"]}, "metabolites": {"3oocoa_c": 1.0, "nadh_c": 1.0, "3hocoa_c": -1.0, "nad_c": -1.0, "h_c": 1.0}, "id": "HACD3i", "gene_reaction_rule": "c2886 or c4793"}, {"subsystem": "Transport Inner Membrane", "name": "Phosphoenolpyruvate phosphate antiporter periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PEPt6pp"]}, "metabolites": {"pi_p": 1.0, "pep_c": 1.0, "pep_p": -1.0, "pi_c": -1.0}, "id": "PEPt6pp", "gene_reaction_rule": "c5201"}, {"subsystem": "Transport Outer Membrane Porin", "name": "3 Phospho D glycerate transport via diffusion extracellular to periplasm ", 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"id": "EX_acon_C_e", "gene_reaction_rule": ""}, {"subsystem": "Transport", "name": "Glycine betaine transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["GLYBt2pp", "GLYBt6pp"]}, "metabolites": {"glyb_c": 1.0, "h_c": 1.0, "h_p": -1.0, "glyb_p": -1.0}, "id": "GLYBt2pp_copy2", "gene_reaction_rule": "c5116"}, {"subsystem": "Arginine and Proline Metabolism", "name": "2-keto-4-methylthiobutyrate transamination", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UNK3"]}, "metabolites": {"akg_c": 1.0, "glu__L_c": -1.0, "2kmb_c": -1.0, "met__L_c": 1.0}, "id": "UNK3", "gene_reaction_rule": "c5031"}, {"subsystem": "Transport", "name": "Hexadecanoate transport via proton symport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HDCAt2pp"]}, "metabolites": {"hdca_c": 1.0, "h_c": 1.0, "h_p": -1.0, "hdca_p": -1.0}, "id": "HDCAt2pp", "gene_reaction_rule": "c2889"}, {"subsystem": "Exchange", "name": "Chitobiose exchange", "upper_bound": 0.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_chitob_LPAREN_e_RPAREN_"]}, "metabolites": {"chitob_e": -1.0}, "id": "EX_chitob_e", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Glycosyl transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ENTERGLCT1"]}, "metabolites": {"udp_c": 1.0, "entermg_c": 1.0, "udpg_c": -1.0, "h_c": 1.0, "enter_c": -1.0}, "id": "ENTERGLCT1", "gene_reaction_rule": "c1254"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Glycosyl transferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["ENTERGLCT2"]}, "metabolites": {"h_c": 1.0, "udp_c": 1.0, "udpg_c": -1.0, "entermg_c": -1.0, "salchs4_c": 1.0}, "id": "ENTERGLCT2", "gene_reaction_rule": "c1254"}, {"subsystem": "Alternate Carbon Metabolism", "name": "D Tagatose 1 phosphate kinase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["TAG1PK"]}, "metabolites": {"tagdp__D_c": 1.0, "tag1p__D_c": -1.0, "atp_c": -1.0, "adp_c": 1.0, "h_c": 1.0}, "id": "TAG1PK", "gene_reaction_rule": "c2121"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxohexanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HACD2i"]}, "metabolites": {"3hhcoa_c": -1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0, "3ohcoa_c": 1.0}, "id": "HACD2i", "gene_reaction_rule": "c4793 or c2886"}, {"subsystem": "Exchange", "name": "Ferrioxamine B exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_feroxB_LPAREN_e_RPAREN_"]}, "metabolites": {"feroxB_e": -1.0}, "id": "EX_feroxB_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "Tricarballylate Exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_tcb_LPAREN_e_RPAREN_"]}, "metabolites": {"tcb_e": -1.0}, "id": "EX_tcb_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "Trithionate Exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_tton_LPAREN_e_RPAREN_"]}, "metabolites": {"tton_e": -1.0}, "id": "EX_tton_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "4-Hydroxy-L-threonine Exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_4hthr_LPAREN_e_RPAREN_"]}, "metabolites": {"4hthr_e": -1.0}, "id": "EX_4hthr_e", "gene_reaction_rule": ""}, {"subsystem": "Transport", "name": "1-deoxy-d-xyluose transport", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DXYLUDtex"]}, "metabolites": {"dxyl_e": -1.0, "dxyl_p": 1.0}, "id": "DXYLUDtex", "gene_reaction_rule": "c0388 or c1822 or c2758"}, {"subsystem": "Transport", "name": "Chitobiose transport via PTS", "upper_bound": 0.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CHITOBpts"]}, "metabolites": {"pep_c": -1.0, "pyr_c": 1.0, "chitob_p": -1.0, "chit6p_c": 1.0}, "id": "CHITOBpts", "gene_reaction_rule": "c2135 and c2137 and c2136 and c2950 and c2951"}, {"subsystem": "Histidine metabolism", "name": "Urocanate hydratase", "upper_bound": 0.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["UROCANH"]}, "metabolites": {"4iz5pp_c": 1.0, "h2o_c": -1.0, "urocan_c": -1.0}, "id": "UROCANH", "gene_reaction_rule": ""}, {"subsystem": "Transport Inner Membrane", "name": "Aminoimidazole riboside facilitated transport periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AIRStpp"]}, "metabolites": {"airs_p": -1.0, "airs_c": 1.0}, "id": "AIRStpp", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "Ferrioxamine E exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_feroxE_LPAREN_e_RPAREN_"]}, "metabolites": {"feroxE_e": -1.0}, "id": "EX_feroxE_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "O-acetyl-L-serine sulfhydrylase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SLCYSS"]}, "metabolites": {"ac_c": 1.0, "acser_c": -1.0, "tsul_c": -1.0, "slcys_c": 1.0}, "id": "SLCYSS", "gene_reaction_rule": "c2955"}, {"subsystem": "Exchange", "name": "Phosphoenolpyruvate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_pep_LPAREN_e_RPAREN_"]}, "metabolites": {"pep_e": -1.0}, "id": "EX_pep_e", "gene_reaction_rule": ""}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxododecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HACD5i"]}, "metabolites": {"3oddcoa_c": 1.0, "nadh_c": 1.0, "3hddcoa_c": -1.0, "nad_c": -1.0, "h_c": 1.0}, "id": "HACD5i", "gene_reaction_rule": "c4793 or c2886"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Salmochelin SX via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": 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-1.0, "atp_c": -1.0, "cysi__L_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "cysi__L_p": -1.0, "pi_c": 1.0}, "id": "CYSIabcpp", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "Oxaloacetate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_oaa_LPAREN_e_RPAREN_"]}, "metabolites": {"oaa_e": -1.0}, "id": "EX_oaa_e", "gene_reaction_rule": ""}, {"subsystem": "Transport", "name": "Octadecanoate transport via proton symport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OCDCAt2pp"]}, "metabolites": {"ocdca_p": -1.0, "h_c": 1.0, "h_p": -1.0, "ocdca_c": 1.0}, "id": "OCDCAt2pp", "gene_reaction_rule": "c2890"}, {"subsystem": "Exchange", "name": "Salmochelin-S2-Fe-III Exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_salchs2fe_LPAREN_e_RPAREN_"]}, "metabolites": {"salchs2fe_e": -1.0}, "id": "EX_salchs2fe_e", "gene_reaction_rule": ""}, {"subsystem": "Transport", "name": "L-gulonate 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"metabolites": {"cysi__L_e": -1.0}, "id": "EX_cysi__L_e", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Salmochelin S4 Fe III binding spontaneous ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SALCHS4FEexs"]}, "metabolites": {"salchs4fe_e": 1.0, "salchs4_e": -1.0, "fe3_e": -1.0}, "id": "SALCHS4FEexs", "gene_reaction_rule": "s0001"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Salmochelin S4 Fe III transport via ABC system periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SALCHS4FEabcpp"]}, "metabolites": {"h2o_c": -1.0, "salchs4fe_c": 1.0, "atp_c": -1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "salchs4fe_p": -1.0}, "id": "SALCHS4FEabcpp", "gene_reaction_rule": "c0679 and c0675 and c0677 and c0676"}, {"subsystem": "Transport Outer Membrane Porin", "name": "Citrate transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, 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"coa_c": 1.0}, "id": "NPHS", "gene_reaction_rule": "c2805"}, {"subsystem": "Transport", "name": "Dodecanoate transport via proton symport", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["DDCAt2pp"]}, "metabolites": {"ddca_c": 1.0, "ddca_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "DDCAt2pp", "gene_reaction_rule": "c2892"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Salmochelin s2 Fe III sequestration", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SALCHS2FEexs"]}, "metabolites": {"salchs2fe_e": 1.0, "salchs2_e": -1.0, "fe3_e": -1.0}, "id": "SALCHS2FEexs", "gene_reaction_rule": "s0001"}, {"subsystem": "Exchange", "name": "Deoxy D Ribose exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_drib_LPAREN_e_RPAREN_"]}, "metabolites": {"drib_e": -1.0}, "id": "EX_drib_e", "gene_reaction_rule": ""}, {"subsystem": "Transport, Inner Membrane", "name": "4-hydroxy-L-threonine 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"EX_rnam_e", "gene_reaction_rule": ""}, {"subsystem": "Transport Inner Membrane", "name": "Deoxy D ribose transport via proton symport periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["DRIBtpp"]}, "metabolites": {"drib_p": -1.0, "h_c": 1.0, "h_p": -1.0, "drib_c": 1.0}, "id": "DRIBtpp", "gene_reaction_rule": "c0332"}, {"subsystem": "Exchange", "name": "Aminoimidazole riboside exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_airs_LPAREN_e_RPAREN_"]}, "metabolites": {"airs_e": -1.0}, "id": "EX_airs_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "1-deoxy-D-xylulose Exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_dxyl_LPAREN_e_RPAREN_"]}, "metabolites": {"dxyl_e": -1.0}, "id": "EX_dxyl_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "3 Phospho D glycerate exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": 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"atp_c": -1.0}, "id": "URIDK2r", "gene_reaction_rule": "c0207"}, {"subsystem": "Transport Outer Membrane Porin", "name": "AEP transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AEPtex"]}, "metabolites": {"AEP_e": -1.0, "AEP_p": 1.0}, "id": "AEPtex", "gene_reaction_rule": "c0388 or c1822 or c2758"}, {"subsystem": "Alanine and Aspartate Metabolism", "name": "Valine-pyruvate aminotransferase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["VPAMTr", "VPAMT"]}, "metabolites": {"pyr_c": 1.0, "3mob_c": -1.0, "ala__L_c": -1.0, "val__L_c": 1.0}, "id": "VPAMTr_copy2", "gene_reaction_rule": "c4393"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxooctadecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HACD8i"]}, "metabolites": {"3hodcoa_c": -1.0, "3oodcoa_c": 1.0, "nadh_c": 1.0, "h_c": 1.0, "nad_c": -1.0}, "id": "HACD8i", "gene_reaction_rule": "c4793 or c2886"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Salmochelin s2 Fe III import", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SALCHS2FEtonex"]}, "metabolites": {"salchs2fe_e": -1.0, "h_c": 1.0, "h_p": -1.0, "salchs2fe_p": 1.0}, "id": "SALCHS2FEtonex", "gene_reaction_rule": "c1250"}, {"subsystem": "Exchange", "name": "Undecaprenyl diphosphate galactose-rhamnose-mannose-abequose Exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_udcpo4_LPAREN_e_RPAREN_"]}, "metabolites": {"udcpo4_e": -1.0}, "id": "EX_udcpo4_e", "gene_reaction_rule": ""}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-hydroxyacyl-CoA dehydrogenase (3-oxotetradecanoyl-CoA)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["HACD6i"]}, "metabolites": {"3otdcoa_c": 1.0, "nadh_c": 1.0, "3htdcoa_c": -1.0, "nad_c": -1.0, "h_c": 1.0}, "id": "HACD6i", "gene_reaction_rule": "c4793 or c2886"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-cis-2-trans-enoyl-CoA isomerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CTECOAI7", "HDCOAI"]}, "metabolites": {"hdcoa_c": -1.0, "hdd2coa_c": 1.0}, "id": "CTECOAI7_copy2", "gene_reaction_rule": "c4793"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Biotin sulfoxide reductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["BSORy"]}, "metabolites": {"h2o_c": 1.0, "nadp_c": 1.0, "nadph_c": -1.0, "btnso_c": -1.0, "btn_c": 1.0, "h_c": -1.0}, "id": "BSORy", "gene_reaction_rule": "c4369"}, {"subsystem": "Exchange", "name": "Ferrioxamine G fe exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_feroxGfe_LPAREN_e_RPAREN_"]}, "metabolites": {"feroxGfe_e": -1.0}, "id": "EX_feroxGfe_e", "gene_reaction_rule": ""}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Salmochelin s2 Fe III transport via ABC system periplasm", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["SALCHS2FEabcpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "salchs2fe_p": -1.0, "salchs2fe_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "SALCHS2FEabcpp", "gene_reaction_rule": "c0679 and c0675 and c0677 and c0676"}, {"subsystem": "Membrane Lipid Metabolism", "name": "3-cis-2-trans-enoyl-CoA isomerase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["CTECOAI6", "TDECOAI"]}, "metabolites": {"tdecoa_c": -1.0, "td2coa_c": 1.0}, "id": "CTECOAI6_copy2", "gene_reaction_rule": "c4793"}, {"subsystem": "Transport Inner Membrane", "name": "Oxaloacetate transport via proton symport 2 H  periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["OAAt2_2pp"]}, "metabolites": {"h_c": 2.0, "oaa_c": 1.0, "h_p": -2.0, "oaa_p": -1.0}, "id": "OAAt2_2pp", "gene_reaction_rule": "c4340"}, {"subsystem": "Inorganic Ion Transport and Metabolism", "name": "Manganese Mn2 transport via ABC system periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MNabc"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "mn2_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "mn2_p": -1.0, "pi_c": 1.0}, "id": "MNabc_1", "gene_reaction_rule": "c1600 and c1599 and c1598 and c1820"}, {"subsystem": "Exchange", "name": "Undecaprenyl diphosphate galactose-rhamnose-mannose-abequose-acetyl Exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_udcpo5_LPAREN_e_RPAREN_"]}, "metabolites": {"udcpo5_e": -1.0}, "id": "EX_udcpo5_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "L-gulonate Exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_guln_L_LPAREN_e_RPAREN_"]}, "metabolites": {"guln__L_e": -1.0}, "id": "EX_guln__L_e", "gene_reaction_rule": ""}, {"subsystem": "Pyruvate Metabolism", "name": "Pyruvate flavodoxin oxidoreductase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PFOR"]}, "metabolites": {"fldrd_c": 1.0, "pyr_c": -1.0, "coa_c": -1.0, "h_c": -1.0, "accoa_c": 1.0, "fldox_c": -1.0, "co2_c": 1.0}, "id": "PFOR", "gene_reaction_rule": "(c0771 and c1823) or (c3475 and c1823)"}, {"subsystem": "Transport", "name": "4-hydroxy-L-threonine transport", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["4HTHRtex"]}, "metabolites": {"4hthr_e": -1.0, "4hthr_p": 1.0}, "id": "4HTHRtex", "gene_reaction_rule": "c0388 or c1822 or c2758"}, {"subsystem": "Transport Outer Membrane Porin", "name": "D Glycerate 2 phosphate transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["2PGtex"]}, "metabolites": {"2pg_e": -1.0, "2pg_p": 1.0}, "id": "2PGtex", "gene_reaction_rule": "c0388 or c1822 or c2758"}, {"subsystem": "Exchange", "name": "Ferrioxamine G exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_feroxG_LPAREN_e_RPAREN_"]}, "metabolites": {"feroxG_e": -1.0}, "id": "EX_feroxG_e", "gene_reaction_rule": ""}, {"subsystem": "Transport Outer Membrane Porin", "name": "Formamide transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["FOAMtex"]}, "metabolites": {"foam_p": 1.0, "foam_e": -1.0}, "id": "FOAMtex", "gene_reaction_rule": "c0388 or c1822 or c2758"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "Thiazole phosphate synthesis", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["THZPSN"]}, "metabolites": {"cys__L_c": -1.0, "h2o_c": 1.0, "atp_c": -1.0, "4mpetz_c": 1.0, "ppi_c": 1.0, "ala__L_c": 1.0, "4hba_c": 1.0, "dxyl5p_c": -1.0, "amp_c": 1.0, "tyr__L_c": -1.0, "co2_c": 1.0, "h_c": 1.0}, "id": "THZPSN", "gene_reaction_rule": "c3056 and c4949 and (c4946 and c4947) and c0534 and c4948"}, {"subsystem": "Transport Inner Membrane", "name": "Enterochelin transport2 via ABC system periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["FEENTER2tpp"]}, "metabolites": {"h2o_c": -1.0, "atp_c": -1.0, "enter_p": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0, "enter_c": -1.0}, "id": "FEENTER2tpp", "gene_reaction_rule": "c1253"}, {"subsystem": "Cofactor and Prosthetic Group Biosynthesis", "name": "2C-methyl-D-erythritol 2,4 cyclodiphosphate dehydratase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["MECDPDH2"]}, "metabolites": {"2mecdp_c": -1.0, "h2o_c": 1.0, "nadh_c": -1.0, "h2mb4p_c": 1.0, "nad_c": 1.0}, "id": "MECDPDH2", "gene_reaction_rule": "c3037"}, {"subsystem": "Exchange", "name": "Agmatine/putrescine antiporter (periplasm)", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["AGMPTRCtpp"]}, "metabolites": {"agm_p": -1.0, "ptrc_p": 1.0, "agm_c": 1.0, "ptrc_c": -1.0}, "id": "AGMPTRCtpp", "gene_reaction_rule": "c0662"}, {"subsystem": "Tranpsort, Inner Membrane", "name": "L-galactonate transport via proton symport (periplasm)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GALCTNLt2pp"]}, "metabolites": {"galctn__L_c": 1.0, "galctn__L_p": -1.0, "h_c": 1.0, "h_p": -1.0}, "id": "GALCTNLt2pp", "gene_reaction_rule": "c4921"}, {"subsystem": "Purine and Pyrimidine Biosynthesis", "name": "Phosphoribosylaminoimidazolesuccinocarboxamide synthase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PRASCSi", "PRASCS"]}, "metabolites": {"atp_c": -1.0, "5aizc_c": -1.0, "asp__L_c": -1.0, "25aics_c": 1.0, "h_c": 1.0, "adp_c": 1.0, "pi_c": 1.0}, "id": "PRASCSi_copy2", "gene_reaction_rule": "c3004"}, {"subsystem": "Glutamate Metabolism", "name": "Glutamate synthase (NADPH)", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLUSy"]}, "metabolites": {"akg_c": -1.0, "nadp_c": 1.0, "nadph_c": -1.0, "glu__L_c": 2.0, "h_c": -1.0, "gln__L_c": -1.0}, "id": "GLUSy", "gene_reaction_rule": "c3973 and c3974"}, {"subsystem": "Exchange", "name": "Diacetyl exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_diact_LPAREN_e_RPAREN_"]}, "metabolites": {"diact_e": -1.0}, "id": "EX_diact_e", "gene_reaction_rule": ""}, {"subsystem": "Tryptophan metabolism", "name": "Tryptophan transaminase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["TRPTA"]}, "metabolites": {"akg_c": -1.0, "glu__L_c": 1.0, "indpyr_c": 1.0, "trp__L_c": -1.0}, "id": "TRPTA", "gene_reaction_rule": "c5031"}, {"subsystem": "Lysine Metabolism", "name": "Piperideine dehydrogenase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["PPRDNDH"]}, "metabolites": {"pprdn_c": -1.0, "h2o_c": -2.0, "5aptn_c": 1.0, "h_c": 1.0, "nad_c": -1.0, "nadh_c": 1.0}, "id": "PPRDNDH", "gene_reaction_rule": "c3880"}, {"subsystem": "Lysine Metabolism", "name": "Glutarate-semialdehyde:NAD+ oxidoreductase", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["OXPTNDH"]}, "metabolites": {"h2o_c": -1.0, "oxptn_c": -1.0, "h_c": 2.0, "nad_c": -1.0, "glutar_c": 1.0, "nadh_c": 1.0}, "id": "OXPTNDH", "gene_reaction_rule": "c3209"}, {"subsystem": "Transport", "name": "Inositol transport in via proton symport", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["INSTt2r"]}, "metabolites": {"inost_e": -1.0, "h_e": -1.0, "inost_c": 1.0, "h_c": 1.0}, "id": "INSTt2", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": " R R  2 3 Butanediol exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_btd_RR_LPAREN_e_RPAREN_"]}, "metabolites": {"btd_RR_e": -1.0}, "id": "EX_btd_RR_e", "gene_reaction_rule": ""}, {"subsystem": "Exchange", "name": "1,3-Propanediol exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": 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"metabolites": {"succoa_c": 1.0, "coa_c": -1.0, "oxadpcoa_c": -1.0, "accoa_c": 1.0}, "id": "3OXCOAT", "gene_reaction_rule": "c3441"}, {"subsystem": "Lysine Metabolism", "name": "Glutaryl-CoA synthetase", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["GLCOAS"]}, "metabolites": {"atp_c": -1.0, "glutcoa_c": 1.0, "coa_c": -1.0, "adp_c": 1.0, "glutar_c": -1.0, "pi_c": 1.0}, "id": "GLCOAS", "gene_reaction_rule": "c0806"}, {"subsystem": "Exchange", "name": "D-Arabitol exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_abt_D_LPAREN_e_RPAREN_"]}, "metabolites": {"abt__D_e": -1.0}, "id": "EX_abt__D_e", "gene_reaction_rule": ""}, {"subsystem": "Transport Inner Membrane", "name": "4 hydroxyphenylacetate transport in via proton symport periplasm ", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["4HOXPACt2pp"]}, "metabolites": {"4hphac_p": -1.0, "4hphac_c": 1.0, "h_c": 1.0, "h_p": -1.0}, "id": 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"Cellobiose transport transport via diffusion extracellular to periplasm ", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["CLBtex"]}, "metabolites": {"cellb_p": 1.0, "cellb_e": -1.0}, "id": "CLBtex", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "S_", "name": "3 hydroxy phenylacetic acid exhcnage", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": {"original_bigg_ids": ["EX_3hoxpac_LPAREN_e_RPAREN_"]}, "metabolites": {"3hoxpac_e": -1.0}, "id": "EX_3hoxpac_e", "gene_reaction_rule": ""}, {"subsystem": "S_penicillin_breakdown", "name": "Penicillin transport via outer membrane porin", "upper_bound": 1000.0, "lower_bound": -1000.0, "notes": {"original_bigg_ids": ["PENGt1"]}, "metabolites": {"peng_e": -1.0, "peng_p": 1.0}, "id": "PENGt1", "gene_reaction_rule": "c0388 or c1071 or c1822 or c2758"}, {"subsystem": "S_", "name": " O6 antigen x4 core oligosaccharide lipid A exchange", "upper_bound": 1000.0, "lower_bound": 0.0, "notes": 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{"original_bigg_ids": ["c1394"]}, "name": "ycfX", "id": "c1394"}, {"notes": {"original_bigg_ids": ["c4704"]}, "name": "rfe", "id": "c4704"}, {"notes": {"original_bigg_ids": ["c2952"]}, "name": "crr", "id": "c2952"}, {"notes": {"original_bigg_ids": ["c1373"]}, "name": "ptsG", "id": "c1373"}, {"notes": {"original_bigg_ids": ["c0755"]}, "name": "nagE", "id": "c0755"}, {"notes": {"original_bigg_ids": ["c2951"]}, "name": "ptsI", "id": "c2951"}, {"notes": {"original_bigg_ids": ["c2950"]}, "name": "ptsH", "id": "c2950"}, {"notes": {"original_bigg_ids": ["c4918"]}, "name": "argB", "id": "c4918"}, {"notes": {"original_bigg_ids": ["c3412"]}, "name": "argA", "id": "c3412"}, {"notes": {"original_bigg_ids": ["c4595"]}, "name": "ilvN", "id": "c4595"}, {"notes": {"original_bigg_ids": ["c4596"]}, "name": "ilvB", "id": "c4596"}, {"notes": {"original_bigg_ids": ["c0095"]}, "name": "ilvI", "id": "c0095"}, {"notes": {"original_bigg_ids": ["c0096"]}, "name": "ilvH", "id": "c0096"}, {"notes": 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{"original_bigg_ids": ["c3087"]}, "name": "acpS", "id": "c3087"}, {"notes": {"original_bigg_ids": ["c4268"]}, "name": "yhhU", "id": "c4268"}, {"notes": {"original_bigg_ids": ["c1961"]}, "name": "ydeD", "id": "c1961"}, {"notes": {"original_bigg_ids": ["c3102"]}, "name": "yfiK", "id": "c3102"}, {"notes": {"original_bigg_ids": ["c5062"]}, "name": "actP", "id": "c5062"}, {"notes": {"original_bigg_ids": ["c2015"]}, "name": "add", "id": "c2015"}, {"notes": {"original_bigg_ids": ["c1366"]}, "name": "pabC", "id": "c1366"}, {"notes": {"original_bigg_ids": ["c4135"]}, "name": "pabA", "id": "c4135"}, {"notes": {"original_bigg_ids": ["c2217"]}, "name": "pabB", "id": "c2217"}, {"notes": {"original_bigg_ids": ["c4589"]}, "name": "yicP", "id": "c4589"}, {"notes": {"original_bigg_ids": ["c4479"]}, "name": "yicE", "id": "c4479"}, {"notes": {"original_bigg_ids": ["c4588"]}, "name": "yicO", "id": "c4588"}, {"notes": {"original_bigg_ids": ["c0594"]}, "name": "adk", "id": "c0594"}, {"notes": 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{"original_bigg_ids": ["c0452"]}, "name": "prpC", "id": "c0452"}, {"notes": {"original_bigg_ids": ["c1361"]}, "name": "fabD", "id": "c1361"}, {"notes": {"original_bigg_ids": ["c3044"]}, "name": "sseA", "id": "c3044"}, {"notes": {"original_bigg_ids": ["c0726"]}, "name": "mrdA", "id": "c0726"}, {"notes": {"original_bigg_ids": ["c4166"]}, "name": "mrcA", "id": "c4166"}, {"notes": {"original_bigg_ids": ["c0183"]}, "name": "mrcB", "id": "c0183"}, {"notes": {"original_bigg_ids": ["c0102"]}, "name": "ftsI", "id": "c0102"}, {"notes": {"original_bigg_ids": ["c0924"]}, "name": "dacC", "id": "c0924"}, {"notes": {"original_bigg_ids": ["c3939"]}, "name": "dacB", "id": "c3939"}, {"notes": {"original_bigg_ids": ["c2538"]}, "name": "dacD", "id": "c2538"}, {"notes": {"original_bigg_ids": ["c0722"]}, "name": "dacA", "id": "c0722"}, {"notes": {"original_bigg_ids": ["c2665"]}, "name": "pbpG", "id": "c2665"}, {"notes": {"original_bigg_ids": ["c2874"]}, "name": "mepA", "id": "c2874"}, {"notes": {"original_bigg_ids": ["c3991"]}, "name": "mdh", "id": "c3991"}, {"notes": {"original_bigg_ids": ["c2751"]}, "name": "yojH", "id": "c2751"}, {"notes": {"original_bigg_ids": ["c1912"]}, "name": "sfcA", "id": "c1912"}, {"notes": {"original_bigg_ids": ["c2988"]}, "name": "None", "id": "c2988"}, {"notes": {"original_bigg_ids": ["c3037"]}, "name": "ispG", "id": "c3037"}, {"notes": {"original_bigg_ids": ["c3313"]}, "name": "ispF", "id": "c3313"}, {"notes": {"original_bigg_ids": ["c3314"]}, "name": "ispD", "id": "c3314"}, {"notes": {"original_bigg_ids": ["c3528"]}, "name": "metK", "id": "c3528"}, {"notes": {"original_bigg_ids": ["c0238"]}, "name": "metQ", "id": "c0238"}, {"notes": {"original_bigg_ids": ["c0240"]}, "name": "metN", "id": "c0240"}, {"notes": {"original_bigg_ids": ["c0239"]}, "name": "yaeE", "id": "c0239"}, {"notes": {"original_bigg_ids": ["c4751"]}, "name": "metE", "id": "c4751"}, {"notes": {"original_bigg_ids": ["c4976"]}, "name": "metH", "id": "c4976"}, {"notes": {"original_bigg_ids": ["c5317"]}, "name": "msrA", "id": "c5317"}, {"notes": {"original_bigg_ids": ["c2183"]}, "name": "yeaA", "id": "c2183"}, {"notes": {"original_bigg_ids": ["c2642"]}, "name": "metG", "id": "c2642"}, {"notes": {"original_bigg_ids": ["c5341"]}, "name": "mgtA", "id": "c5341"}, {"notes": {"original_bigg_ids": ["c1100"]}, "name": "mgsA", "id": "c1100"}, {"notes": {"original_bigg_ids": ["c0513"]}, "name": "malZ", "id": "c0513"}, {"notes": {"original_bigg_ids": ["c1643"]}, "name": "mltE", "id": "c1643"}, {"notes": {"original_bigg_ids": ["c3384"]}, "name": "mltA", "id": "c3384"}, {"notes": {"original_bigg_ids": ["c3081"]}, "name": "yfhD", "id": "c3081"}, {"notes": {"original_bigg_ids": ["c3255"]}, "name": "mltB", "id": "c3255"}, {"notes": {"original_bigg_ids": ["c3551"]}, "name": "mltC", "id": "c3551"}, {"notes": {"original_bigg_ids": ["c5479"]}, "name": "slt", "id": "c5479"}, {"notes": {"original_bigg_ids": ["c3498"]}, "name": "None", "id": "c3498"}, {"notes": {"original_bigg_ids": ["c4416"]}, "name": "mtlA", "id": "c4416"}, {"notes": {"original_bigg_ids": ["c5402"]}, "name": "uxuA", "id": "c5402"}, {"notes": {"original_bigg_ids": ["c0866"]}, "name": "moaD", "id": "c0866"}, {"notes": {"original_bigg_ids": ["c4457"]}, "name": "kdtA", "id": "c4457"}, {"notes": {"original_bigg_ids": ["c4869"]}, "name": "sbp", "id": "c4869"}, {"notes": {"original_bigg_ids": ["c0841"]}, "name": "modB", "id": "c0841"}, {"notes": {"original_bigg_ids": ["c0842"]}, "name": "modC", "id": "c0842"}, {"notes": {"original_bigg_ids": ["c0840"]}, "name": "modA", "id": "c0840"}, {"notes": {"original_bigg_ids": ["c2956"]}, "name": "cysA", "id": "c2956"}, {"notes": {"original_bigg_ids": ["c2958"]}, "name": "cysU", "id": "c2958"}, {"notes": {"original_bigg_ids": ["c2957"]}, "name": "cysW", "id": "c2957"}, {"notes": {"original_bigg_ids": ["c3455"]}, "name": "ygfJ", "id": "c3455"}, {"notes": {"original_bigg_ids": ["c0165"]}, "name": "panB", "id": "c0165"}, {"notes": {"original_bigg_ids": ["c0013"]}, "name": "mogA", "id": "c0013"}, {"notes": {"original_bigg_ids": ["c1338"]}, "name": "mviN", "id": "c1338"}, {"notes": {"original_bigg_ids": ["c3042"]}, "name": "pbpC", "id": "c3042"}, {"notes": {"original_bigg_ids": ["c0867"]}, "name": "moaE", "id": "c0867"}, {"notes": {"original_bigg_ids": ["c0911"]}, "name": "moeB", "id": "c0911"}, {"notes": {"original_bigg_ids": ["c1145"]}, "name": "None", "id": "c1145"}, {"notes": {"original_bigg_ids": ["c0645"]}, "name": "folD", "id": "c0645"}, {"notes": {"original_bigg_ids": ["c4899"]}, "name": "metF", "id": "c4899"}, {"notes": {"original_bigg_ids": ["c1326"]}, "name": "solA", "id": "c1326"}, {"notes": {"original_bigg_ids": ["c4953"]}, "name": "nudC", "id": "c4953"}, {"notes": {"original_bigg_ids": ["c2945"]}, "name": "ligA", "id": "c2945"}, {"notes": {"original_bigg_ids": ["c1382"]}, "name": "ndh", "id": "c1382"}, {"notes": {"original_bigg_ids": ["c2817"]}, "name": "nuoN", "id": "c2817"}, {"notes": {"original_bigg_ids": ["c2827"]}, "name": "nuoC", "id": "c2827"}, {"notes": {"original_bigg_ids": ["c2824"]}, "name": "nuoG", "id": "c2824"}, {"notes": {"original_bigg_ids": ["c2826"]}, "name": "nuoE", "id": "c2826"}, {"notes": {"original_bigg_ids": ["c2819"]}, "name": "nuoL", "id": "c2819"}, {"notes": {"original_bigg_ids": ["c2829"]}, "name": "nuoA", "id": "c2829"}, {"notes": {"original_bigg_ids": ["c2822"]}, "name": "nuoI", "id": "c2822"}, {"notes": {"original_bigg_ids": ["c2821"]}, "name": "nuoJ", "id": "c2821"}, {"notes": {"original_bigg_ids": ["c2825"]}, "name": "nuoF", "id": "c2825"}, {"notes": {"original_bigg_ids": ["c2828"]}, "name": "nuoB", "id": "c2828"}, {"notes": {"original_bigg_ids": ["c2818"]}, "name": "nuoM", "id": "c2818"}, {"notes": {"original_bigg_ids": ["c2823"]}, "name": "nuoH", "id": "c2823"}, {"notes": {"original_bigg_ids": ["c2820"]}, "name": "nuoK", "id": "c2820"}, {"notes": {"original_bigg_ids": ["c3137"]}, "name": "ppnK", "id": "c3137"}, {"notes": {"original_bigg_ids": ["c3768"]}, "name": "mdaB", "id": "c3768"}, {"notes": {"original_bigg_ids": ["c2139"]}, "name": "nadE", "id": "c2139"}, {"notes": {"original_bigg_ids": ["c1995"]}, "name": "pntA", "id": "c1995"}, {"notes": {"original_bigg_ids": ["c4923"]}, "name": "udhA", "id": "c4923"}, {"notes": {"original_bigg_ids": ["c1994"]}, "name": "pntB", "id": "c1994"}, {"notes": {"original_bigg_ids": ["c1073"]}, "name": "pncB", "id": "c1073"}, {"notes": {"original_bigg_ids": ["c1634"]}, "name": "nhaB", "id": "c1634"}, {"notes": {"original_bigg_ids": ["c0024"]}, "name": "nhaA", "id": "c0024"}, {"notes": {"original_bigg_ids": ["c3041"]}, "name": "ndk", "id": "c3041"}, {"notes": {"original_bigg_ids": ["c0570"]}, "name": "amtB", "id": "c0570"}, {"notes": {"original_bigg_ids": ["c3267"]}, "name": "ygbD", "id": "c3267"}, {"notes": {"original_bigg_ids": ["norV"]}, "name": "None", "id": "norV"}, {"notes": {"original_bigg_ids": ["c4272"]}, "name": "nikD", "id": "c4272"}, {"notes": 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{"original_bigg_ids": ["c0372"]}, "name": "gmhA", "id": "c0372"}, {"notes": {"original_bigg_ids": ["c2145"]}, "name": "None", "id": "c2145"}, {"notes": {"original_bigg_ids": ["c3319"]}, "name": "cysD", "id": "c3319"}, {"notes": {"original_bigg_ids": ["c3318"]}, "name": "cysN", "id": "c3318"}, {"notes": {"original_bigg_ids": ["c3259"]}, "name": "srlD", "id": "c3259"}, {"notes": {"original_bigg_ids": ["c3256"]}, "name": "srlA", "id": "c3256"}, {"notes": {"original_bigg_ids": ["c3258"]}, "name": "srlB", "id": "c3258"}, {"notes": {"original_bigg_ids": ["c3257"]}, "name": "srlE", "id": "c3257"}, {"notes": {"original_bigg_ids": ["c2999"]}, "name": "dapE", "id": "c2999"}, {"notes": {"original_bigg_ids": ["c4412"]}, "name": "selA", "id": "c4412"}, {"notes": {"original_bigg_ids": ["c2167"]}, "name": "selD", "id": "c2167"}, {"notes": {"original_bigg_ids": ["c2959"]}, "name": "cysP", "id": "c2959"}, {"notes": {"original_bigg_ids": ["c2808"]}, "name": "menD", "id": "c2808"}, {"notes": 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{"original_bigg_ids": ["k_c"]}, "charge": 1, "formula": "K", "compartment": "c", "id": "k_c"}, {"name": "Glycine", "notes": {"original_bigg_ids": ["gly_c"]}, "charge": 0, "formula": "C2H5NO2", "compartment": "c", "id": "gly_c"}, {"name": "5-Methyltetrahydrofolate", "notes": {"original_bigg_ids": ["5mthf_c"]}, "charge": -1, "formula": "C20H24N7O6", "compartment": "c", "id": "5mthf_c"}, {"name": "Undecaprenyl diphosphate", "notes": {"original_bigg_ids": ["udcpdp_c"]}, "charge": -3, "formula": "C55H89O7P2", "compartment": "c", "id": "udcpdp_c"}, {"name": "Biotin", "notes": {"original_bigg_ids": ["btn_c"]}, "charge": -1, "formula": "C10H15N2O3S", "compartment": "c", "id": "btn_c"}, {"name": "UTP", "notes": {"original_bigg_ids": ["utp_c"]}, "charge": -4, "formula": "C9H11N2O15P3", "compartment": "c", "id": "utp_c"}, {"name": "Molybdate", "notes": {"original_bigg_ids": ["mobd_c"]}, "charge": -2, "formula": "MoO4", "compartment": "c", "id": "mobd_c"}, {"name": "Cardiolipin (tetrahexadecanoyl, n-C16:0)", "notes": {"original_bigg_ids": ["clpn160_p"]}, "charge": -2, "formula": "C73H140O17P2", "compartment": "p", "id": "clpn160_p"}, {"name": "H2O", "notes": {"original_bigg_ids": ["h2o_c"]}, "charge": 0, "formula": "H2O", "compartment": "c", "id": "h2o_c"}, {"name": "Menaquinol 8", "notes": {"original_bigg_ids": ["mql8_c"]}, "charge": 0, "formula": "C51H74O2", "compartment": "c", "id": "mql8_c"}, {"name": "L-Phenylalanine", "notes": {"original_bigg_ids": ["phe_DASH_L_c"]}, "charge": 0, "formula": "C9H11NO2", "compartment": "c", "id": "phe__L_c"}, {"name": "Two linked disacharide tripeptide murein units (uncrosslinked, middle of chain)", "notes": {"original_bigg_ids": ["murein3p3p_p"]}, "charge": -4, "formula": "C68H104N12O38", "compartment": "p", "id": "murein3p3p_p"}, {"name": "Siroheme", "notes": {"original_bigg_ids": ["sheme_c"]}, "charge": -8, "formula": "C42H36FeN4O16", "compartment": "c", "id": "sheme_c"}, {"name": "Ubiquinol-8", "notes": {"original_bigg_ids": ["q8h2_c"]}, "charge": 0, "formula": "C49H76O4", "compartment": "c", "id": "q8h2_c"}, {"name": "Nicotinamide adenine dinucleotide - reduced", "notes": {"original_bigg_ids": ["nadh_c"]}, "charge": -2, "formula": "C21H27N7O14P2", "compartment": "c", "id": "nadh_c"}, {"name": "2-Demethylmenaquinol 8", "notes": {"original_bigg_ids": ["2dmmql8_c"]}, "charge": 0, "formula": "C50H72O2", "compartment": "c", "id": "2dmmql8_c"}, {"name": "L-Methionine", "notes": {"original_bigg_ids": ["met_DASH_L_c"]}, "charge": 0, "formula": "C5H11NO2S", "compartment": "c", "id": "met__L_c"}, {"name": "L-Asparagine", "notes": {"original_bigg_ids": ["asn_DASH_L_c"]}, "charge": 0, "formula": "C4H8N2O3", "compartment": "c", "id": "asn__L_c"}, {"name": "Three disacharide linked murein units (tetrapeptide crosslinked tetrapeptide (A2pm->D-ala) & tetrapeptide corsslinked tetrapeptide (A2pm->D-ala)) (middle of chain)", "notes": {"original_bigg_ids": ["murein4px4px4p_p"]}, "charge": -6, "formula": "C111H167N21O58", "compartment": "p", "id": "murein4px4px4p_p"}, {"name": "Flavin adenine dinucleotide oxidized", "notes": {"original_bigg_ids": ["fad_c"]}, "charge": -2, "formula": "C27H31N9O15P2", "compartment": "c", "id": "fad_c"}, {"name": "Phosphatidylethanolamine (dihexadecanoyl, n-C16:0)", "notes": {"original_bigg_ids": ["pe160_c"]}, "charge": 0, "formula": "C37H74N1O8P1", "compartment": "c", "id": "pe160_c"}, {"name": "Enterochelin", "notes": {"original_bigg_ids": ["enter_c"]}, "charge": 0, "formula": "C30H27N3O15", "compartment": "c", "id": "enter_c"}, {"name": "Phosphatidylglycerol (dihexadec-9-enoyl, n-C16:1)", "notes": {"original_bigg_ids": ["pg161_c"]}, "charge": -1, "formula": "C38H70O10P1", "compartment": "c", "id": "pg161_c"}, {"name": "Mn2+", "notes": {"original_bigg_ids": ["mn2_c"]}, "charge": 2, "formula": "Mn", "compartment": "c", "id": "mn2_c"}, {"name": "Phosphatidylethanolamine (dioctadec-11-enoyl, n-C18:1)", "notes": {"original_bigg_ids": ["pe181_p"]}, "charge": 0, "formula": "C41H78N1O8P1", "compartment": "p", "id": "pe181_p"}, {"name": "Phosphatidylethanolamine (dihexadec-9enoyl, n-C16:1)", "notes": {"original_bigg_ids": ["pe161_c"]}, "charge": 0, "formula": "C37H70N1O8P1", "compartment": "c", "id": "pe161_c"}, {"name": "L-Proline", "notes": {"original_bigg_ids": ["pro_DASH_L_c"]}, "charge": 0, "formula": "C5H9NO2", "compartment": "c", "id": "pro__L_c"}, {"name": "Phosphatidylglycerol (dihexadecanoyl, n-C16:0)", "notes": {"original_bigg_ids": ["pg160_p"]}, "charge": -1, "formula": "C38H74O10P1", "compartment": "p", "id": "pg160_p"}, {"name": "L-Tryptophan", "notes": {"original_bigg_ids": ["trp_DASH_L_c"]}, "charge": 0, "formula": "C11H12N2O2", "compartment": "c", "id": "trp__L_c"}, {"name": "DATP", "notes": {"original_bigg_ids": ["datp_c"]}, "charge": -4, "formula": "C10H12N5O12P3", "compartment": "c", "id": "datp_c"}, {"name": "Succinyl-CoA", "notes": {"original_bigg_ids": ["succoa_c"]}, "charge": -5, "formula": "C25H35N7O19P3S", "compartment": "c", "id": "succoa_c"}, {"name": "L-Aspartate", "notes": {"original_bigg_ids": ["asp_DASH_L_c"]}, "charge": -1, "formula": "C4H6NO4", "compartment": "c", "id": "asp__L_c"}, {"name": "DGTP", "notes": {"original_bigg_ids": ["dgtp_c"]}, "charge": -4, "formula": "C10H12N5O13P3", "compartment": "c", "id": "dgtp_c"}, {"name": "Core oligosaccharide lipid A", "notes": {"original_bigg_ids": ["colipa_e"]}, "charge": -11, "formula": "C176H303N2O100P4", "compartment": "e", "id": "colipa_e"}, {"name": "Zinc", "notes": {"original_bigg_ids": ["zn2_c"]}, "charge": 2, "formula": "Zn", "compartment": "c", "id": "zn2_c"}, {"name": "Phosphatidylethanolamine (dihexadecanoyl, n-C16:0)", "notes": {"original_bigg_ids": ["pe160_p"]}, "charge": 0, "formula": "C37H74N1O8P1", "compartment": "p", "id": "pe160_p"}, {"name": "Spermidine", "notes": {"original_bigg_ids": ["spmd_c"]}, "charge": 3, "formula": "C7H22N3", "compartment": "c", "id": "spmd_c"}, {"name": "Two disacharide linked murein units, pentapeptide crosslinked tetrapeptide (A2pm->D-ala) (middle of chain)", "notes": {"original_bigg_ids": ["murein5px4p_p"]}, "charge": -4, "formula": "C77H117N15O40", "compartment": "p", "id": "murein5px4p_p"}, {"name": "2-Octaprenyl-6-hydroxyphenol", "notes": {"original_bigg_ids": ["2ohph_c"]}, "charge": 0, "formula": "C46H70O2", "compartment": "c", "id": "2ohph_c"}, {"name": "KDO(2)-lipid IV(A)", "notes": {"original_bigg_ids": ["kdo2lipid4_e"]}, "charge": -6, "formula": "C84H148N2O37P2", "compartment": "e", "id": "kdo2lipid4_e"}, {"name": "(R)-Propane-1,2-diol", "notes": {"original_bigg_ids": ["12ppd_DASH_R_e"]}, "charge": 0, "formula": "C3H8O2", "compartment": "e", "id": "12ppd__R_e"}, {"name": "(S)-Propane-1,2-diol", "notes": {"original_bigg_ids": ["12ppd_DASH_S_e"]}, "charge": 0, "formula": "C3H8O2", "compartment": "e", "id": "12ppd__S_e"}, {"name": "1,4-alpha-D-glucan", "notes": {"original_bigg_ids": ["14glucan_e"]}, "charge": 0, "formula": "C36H62O31", "compartment": "e", "id": "14glucan_e"}, {"name": "1,5-Diaminopentane", "notes": {"original_bigg_ids": ["15dap_e"]}, "charge": 2, "formula": "C5H16N2", "compartment": "e", "id": "15dap_e"}, {"name": "2',3'-Cyclic AMP", "notes": {"original_bigg_ids": ["23camp_e"]}, "charge": -1, "formula": "C10H11N5O6P", "compartment": "e", "id": "23camp_e"}, {"name": "2',3'-Cyclic CMP", "notes": {"original_bigg_ids": ["23ccmp_e"]}, "charge": -1, "formula": "C9H11N3O7P", "compartment": "e", "id": "23ccmp_e"}, {"name": "2',3'-Cyclic GMP", "notes": {"original_bigg_ids": ["23cgmp_e"]}, "charge": -1, "formula": "C10H11N5O7P", "compartment": "e", "id": "23cgmp_e"}, {"name": "2',3'-Cyclic UMP", "notes": {"original_bigg_ids": ["23cump_e"]}, "charge": -1, "formula": "C9H10N2O8P", "compartment": "e", "id": "23cump_e"}, {"name": "2,3-diaminopropionate", "notes": {"original_bigg_ids": ["23dappa_e"]}, "charge": 1, "formula": "C3H9N2O2", "compartment": "e", "id": "23dappa_e"}, {"name": "Meso-2,6-Diaminoheptanedioate", "notes": {"original_bigg_ids": ["26dap_DASH_M_e"]}, "charge": 0, "formula": "C7H14N2O4", "compartment": "e", "id": "26dap__M_e"}, {"name": "2-Dehydro-3-deoxy-D-gluconate", "notes": {"original_bigg_ids": ["2ddglcn_e"]}, "charge": -1, "formula": "C6H9O6", "compartment": "e", "id": "2ddglcn_e"}, {"name": "3,4-Dihydroxyphenylacetaldehyde", "notes": {"original_bigg_ids": ["34dhpac_e"]}, "charge": 0, "formula": "C8H8O3", "compartment": "e", "id": "34dhpac_e"}, {"name": "3'-AMP", "notes": {"original_bigg_ids": ["3amp_e"]}, "charge": -2, "formula": "C10H12N5O7P", "compartment": "e", "id": "3amp_e"}, {"name": "3'-cmp", "notes": {"original_bigg_ids": ["3cmp_e"]}, "charge": -2, "formula": "C9H12N3O8P", "compartment": "e", "id": "3cmp_e"}, {"name": "3'-GMP", "notes": {"original_bigg_ids": ["3gmp_e"]}, "charge": -2, "formula": "C10H12N5O8P", "compartment": "e", "id": "3gmp_e"}, {"name": "3-hydroxycinnamic acid", "notes": {"original_bigg_ids": ["3hcinnm_e"]}, "charge": -1, "formula": "C9H7O3", "compartment": "e", "id": "3hcinnm_e"}, {"name": "3-Hydroxypropanoate", "notes": {"original_bigg_ids": ["3hpp_e"]}, "charge": -1, "formula": "C3H5O3", "compartment": "e", "id": "3hpp_e"}, {"name": "3-(3-hydroxy-phenyl)propionate", "notes": {"original_bigg_ids": ["3hpppn_e"]}, "charge": -1, "formula": "C9H9O3", "compartment": "e", "id": "3hpppn_e"}, {"name": "3'-UMP", "notes": {"original_bigg_ids": ["3ump_e"]}, "charge": -2, "formula": "C9H11N2O9P", "compartment": "e", "id": "3ump_e"}, {"name": "4-Aminobutanoate", "notes": {"original_bigg_ids": ["4abut_e"]}, "charge": 0, "formula": "C4H9NO2", "compartment": "e", "id": "4abut_e"}, {"name": "4-Hydroxyphenylacetaldehyde", "notes": {"original_bigg_ids": ["4hoxpacd_e"]}, "charge": 0, "formula": "C8H8O2", "compartment": "e", "id": "4hoxpacd_e"}, {"name": "5-Dehydro-D-gluconate", "notes": {"original_bigg_ids": ["5dglcn_e"]}, "charge": -1, "formula": "C6H9O7", "compartment": "e", "id": "5dglcn_e"}, {"name": "5-Methylthio-D-ribose", "notes": {"original_bigg_ids": ["5mtr_e"]}, "charge": 0, "formula": "C6H12O4S", "compartment": "e", "id": "5mtr_e"}, {"name": "L-alanine-D-glutamate", "notes": {"original_bigg_ids": ["LalaDglu_e"]}, "charge": -1, "formula": "C8H13N2O5", "compartment": "e", "id": "LalaDglu_e"}, {"name": "L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate", "notes": {"original_bigg_ids": ["LalaDgluMdap_e"]}, "charge": -1, "formula": "C15H25N4O8", "compartment": "e", "id": "LalaDgluMdap_e"}, {"name": "L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine", "notes": {"original_bigg_ids": ["LalaDgluMdapDala_e"]}, "charge": -1, "formula": "C18H30N5O9", "compartment": "e", "id": "LalaDgluMdapDala_e"}, {"name": "L-alanine-L-glutamate", "notes": {"original_bigg_ids": ["LalaLglu_e"]}, "charge": -1, "formula": "C8H13N2O5", "compartment": "e", "id": "LalaLglu_e"}, {"name": "Acetate", "notes": {"original_bigg_ids": ["ac_e"]}, "charge": -1, "formula": "C2H3O2", "compartment": "e", "id": "ac_e"}, {"name": "Acetoacetate", "notes": {"original_bigg_ids": ["acac_e"]}, "charge": -1, "formula": "C4H5O3", "compartment": "e", "id": "acac_e"}, {"name": "Acetaldehyde", "notes": {"original_bigg_ids": ["acald_e"]}, "charge": 0, "formula": "C2H4O", "compartment": "e", "id": "acald_e"}, {"name": "N-Acetyl-D-galactosamine", "notes": {"original_bigg_ids": ["acgal_e"]}, "charge": 0, "formula": "C8H15NO6", "compartment": "e", "id": "acgal_e"}, {"name": "N-Acetyl-D-galactosamine 1-phosphate", "notes": {"original_bigg_ids": ["acgal1p_e"]}, "charge": -2, "formula": "C8H14NO9P", "compartment": "e", "id": "acgal1p_e"}, {"name": "N-Acetyl-D-glucosamine", "notes": {"original_bigg_ids": ["acgam_e"]}, "charge": 0, "formula": "C8H15NO6", "compartment": "e", "id": "acgam_e"}, {"name": "N-Acetyl-D-glucosamine 1-phosphate", "notes": {"original_bigg_ids": ["acgam1p_e"]}, "charge": -2, "formula": "C8H14NO9P", "compartment": "e", "id": "acgam1p_e"}, {"name": "N-Acetyl-D-mannosamine", "notes": {"original_bigg_ids": ["acmana_e"]}, "charge": 0, "formula": "C8H15NO6", "compartment": "e", "id": "acmana_e"}, {"name": "N-Acetylmuramate", "notes": {"original_bigg_ids": ["acmum_e"]}, "charge": -1, "formula": "C11H18NO8", "compartment": "e", "id": "acmum_e"}, {"name": "N-Acetylneuraminate", "notes": {"original_bigg_ids": ["acnam_e"]}, "charge": -1, "formula": "C11H18NO9", "compartment": "e", "id": "acnam_e"}, {"name": "4-Amino-4-deoxy-L-arabinose modified core oligosaccharide lipid A", "notes": {"original_bigg_ids": ["acolipa_e"]}, "charge": -9, "formula": "C181H314N3O103P4", "compartment": "e", "id": "acolipa_e"}, {"name": "O-Acetyl-L-serine", "notes": {"original_bigg_ids": ["acser_e"]}, "charge": 0, "formula": "C5H9NO4", "compartment": "e", "id": "acser_e"}, {"name": "Adenine", "notes": {"original_bigg_ids": ["ade_e"]}, "charge": 0, "formula": "C5H5N5", "compartment": "e", "id": "ade_e"}, {"name": "Adenosine", "notes": {"original_bigg_ids": ["adn_e"]}, "charge": 0, "formula": "C10H13N5O4", "compartment": "e", "id": "adn_e"}, {"name": "Adenosylcobalamin", "notes": {"original_bigg_ids": ["adocbl_e"]}, "charge": 0, "formula": "C72H100CoN18O17P", "compartment": "e", "id": "adocbl_e"}, {"name": "Silver", "notes": {"original_bigg_ids": ["ag_e"]}, "charge": 1, "formula": "Ag", "compartment": "e", "id": "ag_e"}, {"name": "Agmatine", "notes": {"original_bigg_ids": ["agm_e"]}, "charge": 2, "formula": "C5H16N4", "compartment": "e", "id": "agm_e"}, {"name": "2-Oxoglutarate", "notes": {"original_bigg_ids": ["akg_e"]}, "charge": -2, "formula": "C5H4O5", "compartment": "e", "id": "akg_e"}, {"name": "Beta-Alanine", "notes": {"original_bigg_ids": ["ala_DASH_B_e"]}, "charge": 0, "formula": "C3H7NO2", "compartment": "e", "id": "ala_B_e"}, {"name": "D-Alanine", "notes": {"original_bigg_ids": ["ala_DASH_D_e"]}, "charge": 0, "formula": "C3H7NO2", "compartment": "e", "id": "ala__D_e"}, {"name": "L-Alanine", "notes": {"original_bigg_ids": ["ala_DASH_L_e"]}, "charge": 0, "formula": "C3H7NO2", "compartment": "e", "id": "ala__L_e"}, 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"D-Carnitine", "notes": {"original_bigg_ids": ["crn_DASH_D_e"]}, "charge": 0, "formula": "C7H15NO3", "compartment": "e", "id": "crn__D_e"}, {"name": "Cytosine", "notes": {"original_bigg_ids": ["csn_e"]}, "charge": 0, "formula": "C4H5N3O", "compartment": "e", "id": "csn_e"}, {"name": "Cu+", "notes": {"original_bigg_ids": ["cu_e"]}, "charge": 1, "formula": "Cu", "compartment": "e", "id": "cu_e"}, {"name": "Cu2+", "notes": {"original_bigg_ids": ["cu2_e"]}, "charge": 2, "formula": "Cu", "compartment": "e", "id": "cu2_e"}, {"name": "Hydrogen cyanide", "notes": {"original_bigg_ids": ["cyan_e"]}, "charge": 0, "formula": "CHN", "compartment": "e", "id": "cyan_e"}, {"name": "Cyanate", "notes": {"original_bigg_ids": ["cynt_e"]}, "charge": -1, "formula": "CNO", "compartment": "e", "id": "cynt_e"}, {"name": "D-Cysteine", "notes": {"original_bigg_ids": ["cys_DASH_D_e"]}, "charge": 0, "formula": "C3H7NO2S", "compartment": "e", "id": "cys__D_e"}, {"name": "L-Cysteine", "notes": {"original_bigg_ids": 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"e", "id": "eca4colipa_e"}, {"name": "Phosphoethanolamine KDO(2)-lipid (A)", "notes": {"original_bigg_ids": ["enlipa_e"]}, "charge": -6, "formula": "C112H202N3O42P3", "compartment": "e", "id": "enlipa_e"}, {"name": "Enterochelin", "notes": {"original_bigg_ids": ["enter_e"]}, "charge": 0, "formula": "C30H27N3O15", "compartment": "e", "id": "enter_e"}, {"name": "Ethanolamine", "notes": {"original_bigg_ids": ["etha_e"]}, "charge": 1, "formula": "C2H8NO", "compartment": "e", "id": "etha_e"}, {"name": "Ethanesulfonate", "notes": {"original_bigg_ids": ["ethso3_e"]}, "charge": -1, "formula": "C2H5O3S", "compartment": "e", "id": "ethso3_e"}, {"name": "Ethanol", "notes": {"original_bigg_ids": ["etoh_e"]}, "charge": 0, "formula": "C2H6O", "compartment": "e", "id": "etoh_e"}, {"name": "D-Fructose 6-phosphate", "notes": {"original_bigg_ids": ["f6p_e"]}, "charge": -2, "formula": "C6H11O9P", "compartment": "e", "id": "f6p_e"}, {"name": "Formaldehyde", "notes": {"original_bigg_ids": ["fald_e"]}, 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"notes": {"original_bigg_ids": ["lys_DASH_L_e"]}, "charge": 1, "formula": "C6H15N2O2", "compartment": "e", "id": "lys__L_e"}, {"name": "L-Lyxose", "notes": {"original_bigg_ids": ["lyx_DASH_L_e"]}, "charge": 0, "formula": "C5H10O5", "compartment": "e", "id": "lyx__L_e"}, {"name": "D-Malate", "notes": {"original_bigg_ids": ["mal_DASH_D_e"]}, "charge": -2, "formula": "C4H4O5", "compartment": "e", "id": "mal__D_e"}, {"name": "L-Malate", "notes": {"original_bigg_ids": ["mal_DASH_L_e"]}, "charge": -2, "formula": "C4H4O5", "compartment": "e", "id": "mal__L_e"}, {"name": "Maltose", "notes": {"original_bigg_ids": ["malt_e"]}, "charge": 0, "formula": "C12H22O11", "compartment": "e", "id": "malt_e"}, {"name": "Maltohexaose", "notes": {"original_bigg_ids": ["malthx_e"]}, "charge": 0, "formula": "C36H62O31", "compartment": "e", "id": "malthx_e"}, {"name": "Maltopentaose", "notes": {"original_bigg_ids": ["maltpt_e"]}, "charge": 0, "formula": "C30H52O26", "compartment": "e", "id": "maltpt_e"}, {"name": "Maltotriose", "notes": {"original_bigg_ids": ["malttr_e"]}, "charge": 0, "formula": "C18H32O16", "compartment": "e", "id": "malttr_e"}, {"name": "Maltotetraose", "notes": {"original_bigg_ids": ["maltttr_e"]}, "charge": 0, "formula": "C24H42O21", "compartment": "e", "id": "maltttr_e"}, {"name": "D-Mannose", "notes": {"original_bigg_ids": ["man_e"]}, "charge": 0, "formula": "C6H12O6", "compartment": "e", "id": "man_e"}, {"name": "D-Mannose 6-phosphate", "notes": {"original_bigg_ids": ["man6p_e"]}, "charge": -2, "formula": "C6H11O9P", "compartment": "e", "id": "man6p_e"}, {"name": "2(alpha-D-Mannosyl)-D-glycerate", "notes": {"original_bigg_ids": ["manglyc_e"]}, "charge": -1, "formula": "C9H15O9", "compartment": "e", "id": "manglyc_e"}, {"name": "Melibiose", "notes": {"original_bigg_ids": ["melib_e"]}, "charge": 0, "formula": "C12H22O11", "compartment": "e", "id": "melib_e"}, {"name": "Methanol", "notes": {"original_bigg_ids": ["meoh_e"]}, "charge": 0, "formula": "CH4O1", "compartment": "e", "id": "meoh_e"}, {"name": "D-Methionine", "notes": {"original_bigg_ids": ["met_DASH_D_e"]}, "charge": 0, "formula": "C5H10NO2S", "compartment": "e", "id": "met__D_e"}, {"name": "L-Methionine", "notes": {"original_bigg_ids": ["met_DASH_L_e"]}, "charge": 0, "formula": "C5H11NO2S", "compartment": "e", "id": "met__L_e"}, {"name": "L-methionine-R-sulfoxide", "notes": {"original_bigg_ids": ["metsox_DASH_R_DASH_L_e"]}, "charge": 0, "formula": "C5H11NO3S", "compartment": "e", "id": "metsox_R__L_e"}, {"name": "L-Methionine Sulfoxide", "notes": {"original_bigg_ids": ["metsox_DASH_S_DASH_L_e"]}, "charge": 0, "formula": "C5H11NO3S", "compartment": "e", "id": "metsox_S__L_e"}, {"name": "Magnesium", "notes": {"original_bigg_ids": ["mg2_e"]}, "charge": 2, "formula": "Mg", "compartment": "e", "id": "mg2_e"}, {"name": "Minocycline", "notes": {"original_bigg_ids": ["mincyc_e"]}, "charge": 0, "formula": "C23H27N3O7", "compartment": "e", "id": "mincyc_e"}, {"name": "Myo-Inositol 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"notes": {"original_bigg_ids": ["na1_e"]}, "charge": 1, "formula": "Na", "compartment": "e", "id": "na1_e"}, {"name": "Nicotinate", "notes": {"original_bigg_ids": ["nac_e"]}, "charge": -1, "formula": "C6H4NO2", "compartment": "e", "id": "nac_e"}, {"name": "Ammonium", "notes": {"original_bigg_ids": ["nh4_e"]}, "charge": 1, "formula": "H4N", "compartment": "e", "id": "nh4_e"}, {"name": "Nickel", "notes": {"original_bigg_ids": ["ni2_e"]}, "charge": 2, "formula": "Ni", "compartment": "e", "id": "ni2_e"}, {"name": "NMN", "notes": {"original_bigg_ids": ["nmn_e"]}, "charge": -1, "formula": "C11H14N2O8P", "compartment": "e", "id": "nmn_e"}, {"name": "Nitric oxide", "notes": {"original_bigg_ids": ["no_e"]}, "charge": 0, "formula": "NO", "compartment": "e", "id": "no_e"}, {"name": "Nitrite", "notes": {"original_bigg_ids": ["no2_e"]}, "charge": -1, "formula": "NO2", "compartment": "e", "id": "no2_e"}, {"name": "Nitrate", "notes": {"original_bigg_ids": ["no3_e"]}, "charge": -1, "formula": "NO3", "compartment": "e", "id": "no3_e"}, {"name": "Novobiocin", "notes": {"original_bigg_ids": ["novbcn_e"]}, "charge": 0, "formula": "C31H36N2O11", "compartment": "e", "id": "novbcn_e"}, {"name": "(O16 antigen)x4 core oligosaccharide lipid A", "notes": {"original_bigg_ids": ["o16a4colipa_e"]}, "charge": -11, "formula": "C312H523N6O200P4", "compartment": "e", "id": "o16a4colipa_e"}, {"name": "O2", "notes": {"original_bigg_ids": ["o2_e"]}, "charge": 0, "formula": "O2", "compartment": "e", "id": "o2_e"}, {"name": "Superoxide anion", "notes": {"original_bigg_ids": ["o2s_e"]}, "charge": -1, "formula": "O2", "compartment": "e", "id": "o2s_e"}, {"name": "Octadecanoate (n-C18:0)", "notes": {"original_bigg_ids": ["ocdca_e"]}, "charge": -1, "formula": "C18H35O2", "compartment": "e", "id": "ocdca_e"}, {"name": "Octadecenoate (n-C18:1)", "notes": {"original_bigg_ids": ["ocdcea_e"]}, "charge": -1, "formula": "C18H33O2", "compartment": "e", "id": "ocdcea_e"}, {"name": "Octanoate (n-C8:0)", "notes": 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"id": "pydxn_e"}, {"name": "Pyruvate", "notes": {"original_bigg_ids": ["pyr_e"]}, "charge": -1, "formula": "C3H3O3", "compartment": "e", "id": "pyr_e"}, {"name": "Quinate", "notes": {"original_bigg_ids": ["quin_e"]}, "charge": 0, "formula": "C7H12O6", "compartment": "e", "id": "quin_e"}, {"name": "Alpha-D-Ribose 5-phosphate", "notes": {"original_bigg_ids": ["r5p_e"]}, "charge": -2, "formula": "C5H9O8P", "compartment": "e", "id": "r5p_e"}, {"name": "Rifampin", "notes": {"original_bigg_ids": ["rfamp_e"]}, "charge": 0, "formula": "C43H58N4O12", "compartment": "e", "id": "rfamp_e"}, {"name": "D-Ribose", "notes": {"original_bigg_ids": ["rib_DASH_D_e"]}, "charge": 0, "formula": "C5H10O5", "compartment": "e", "id": "rib__D_e"}, {"name": "L-Rhamnose", "notes": {"original_bigg_ids": ["rmn_e"]}, "charge": 0, "formula": "C6H12O5", "compartment": "e", "id": "rmn_e"}, {"name": "D-Sorbitol", "notes": {"original_bigg_ids": ["sbt_DASH_D_e"]}, "charge": 0, "formula": "C6H14O6", "compartment": "e", 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"id": "ttdcea_c"}, {"name": "Hexadecanoate (n-C16:0)", "notes": {"original_bigg_ids": ["hdca_c"]}, "charge": -1, "formula": "C16H31O2", "compartment": "c", "id": "hdca_c"}, {"name": "Hexadecenoate (n-C16:1)", "notes": {"original_bigg_ids": ["hdcea_c"]}, "charge": -1, "formula": "C16H29O2", "compartment": "c", "id": "hdcea_c"}, {"name": "Octadecanoate (n-C18:0)", "notes": {"original_bigg_ids": ["ocdca_c"]}, "charge": -1, "formula": "C18H35O2", "compartment": "c", "id": "ocdca_c"}, {"name": "Phosphatidylethanolamine (dioctadecanoyl, n-C18:0)", "notes": {"original_bigg_ids": ["pe180_c"]}, "charge": 0, "formula": "C41H82N1O8P1", "compartment": "c", "id": "pe180_c"}, {"name": "Octadecenoate (n-C18:1)", "notes": {"original_bigg_ids": ["ocdcea_c"]}, "charge": -1, "formula": "C18H33O2", "compartment": "c", "id": "ocdcea_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C12:0)", "notes": {"original_bigg_ids": ["2agpg120_c"]}, "charge": -1, "formula": "C18H36O9P1", "compartment": "c", "id": "2agpg120_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C12:0)", "notes": {"original_bigg_ids": ["2agpg120_p"]}, "charge": -1, "formula": "C18H36O9P1", "compartment": "p", "id": "2agpg120_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C14:0)", "notes": {"original_bigg_ids": ["2agpg140_p"]}, "charge": -1, "formula": "C20H40O9P1", "compartment": "p", "id": "2agpg140_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C14:0)", "notes": {"original_bigg_ids": ["2agpg140_c"]}, "charge": -1, "formula": "C20H40O9P1", "compartment": "c", "id": "2agpg140_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C14:1)", "notes": {"original_bigg_ids": ["2agpg141_p"]}, "charge": -1, "formula": "C20H38O9P1", "compartment": "p", "id": "2agpg141_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C14:1)", "notes": {"original_bigg_ids": ["2agpg141_c"]}, "charge": -1, "formula": "C20H38O9P1", "compartment": "c", "id": "2agpg141_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:0)", "notes": {"original_bigg_ids": ["2agpg160_c"]}, "charge": -1, "formula": "C22H44O9P1", "compartment": "c", "id": "2agpg160_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:0)", "notes": {"original_bigg_ids": ["2agpg160_p"]}, "charge": -1, "formula": "C22H44O9P1", "compartment": "p", "id": "2agpg160_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:1)", "notes": {"original_bigg_ids": ["2agpg161_p"]}, "charge": -1, "formula": "C22H42O9P1", "compartment": "p", "id": "2agpg161_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C16:1)", "notes": {"original_bigg_ids": ["2agpg161_c"]}, "charge": -1, "formula": "C22H42O9P1", "compartment": "c", "id": "2agpg161_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:0)", "notes": {"original_bigg_ids": ["2agpg180_p"]}, "charge": -1, "formula": "C24H48O9P1", "compartment": "p", "id": "2agpg180_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:0)", "notes": {"original_bigg_ids": ["2agpg180_c"]}, "charge": -1, "formula": "C24H48O9P1", "compartment": "c", "id": "2agpg180_c"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:1)", "notes": {"original_bigg_ids": ["2agpg181_p"]}, "charge": -1, "formula": "C24H46O9P1", "compartment": "p", "id": "2agpg181_p"}, {"name": "2-Acyl-sn-glycero-3-phosphoglycerol (n-C18:1)", "notes": {"original_bigg_ids": ["2agpg181_c"]}, "charge": -1, "formula": "C24H46O9P1", "compartment": "c", "id": "2agpg181_c"}, {"name": "Phosphatidylglycerol (didodecanoyl, n-C12:0)", "notes": {"original_bigg_ids": ["pg120_c"]}, "charge": -1, "formula": "C30H58O10P1", "compartment": "c", "id": "pg120_c"}, {"name": "Phosphatidylglycerol (ditetradecanoyl, n-C14:0)", "notes": {"original_bigg_ids": ["pg140_c"]}, "charge": -1, "formula": "C34H66O10P1", "compartment": "c", "id": "pg140_c"}, {"name": "Phosphatidylglycerol (ditetradec-7-enoyl, n-C14:1)", "notes": {"original_bigg_ids": ["pg141_c"]}, "charge": -1, "formula": "C34H62O10P1", "compartment": "c", "id": "pg141_c"}, {"name": "Phosphatidylglycerol (dioctadecanoyl, n-C18:0)", "notes": {"original_bigg_ids": ["pg180_c"]}, "charge": -1, "formula": "C42H82O10P1", "compartment": "c", "id": "pg180_c"}, {"name": "2-Dehydro-L-gulonate", "notes": {"original_bigg_ids": ["2dhguln_c"]}, "charge": -1, "formula": "C6H9O7", "compartment": "c", "id": "2dhguln_c"}, {"name": "D-Gluconate", "notes": {"original_bigg_ids": ["glcn_c"]}, "charge": -1, "formula": "C6H11O7", "compartment": "c", "id": "glcn_c"}, {"name": "L-Idonate", "notes": {"original_bigg_ids": ["idon_DASH_L_c"]}, "charge": -1, "formula": "C6H11O7", "compartment": "c", "id": "idon__L_c"}, {"name": "4-Amino-2-methyl-5-phosphomethylpyrimidine", "notes": {"original_bigg_ids": ["4ampm_c"]}, "charge": -2, "formula": "C6H8N3O4P", "compartment": "c", "id": "4ampm_c"}, {"name": "2-Methyl-4-amino-5-hydroxymethylpyrimidine diphosphate", "notes": {"original_bigg_ids": ["2mahmp_c"]}, "charge": -3, "formula": "C6H8N3O7P2", "compartment": "c", "id": "2mahmp_c"}, {"name": "3,4-Dihydroxyphenylacetaldehyde", "notes": {"original_bigg_ids": ["34dhpac_p"]}, "charge": 0, "formula": "C8H8O3", "compartment": "p", "id": "34dhpac_p"}, {"name": "3-Aminoacrylate", "notes": {"original_bigg_ids": ["3amac_c"]}, "charge": -1, "formula": "C3H4NO2", "compartment": "c", "id": "3amac_c"}, {"name": "Malonate semialdehyde", "notes": {"original_bigg_ids": ["msa_c"]}, "charge": -1, "formula": "C3H3O3", "compartment": "c", "id": "msa_c"}, {"name": "Trans-Dec-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["tdec2eACP_c"]}, "charge": -1, "formula": "C21H37N2O8PRS", "compartment": "c", "id": "tdec2eACP_c"}, {"name": "(R)-3-Hydroxydecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hdecACP_c"]}, "charge": -1, "formula": "C21H39N2O9PRS", "compartment": "c", "id": "3hdecACP_c"}, {"name": "(R)-3-Hydroxydodecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hddecACP_c"]}, "charge": -1, "formula": "C23H43N2O9PRS", "compartment": "c", "id": "3hddecACP_c"}, {"name": "Trans-Dodec-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["tddec2eACP_c"]}, "charge": -1, "formula": "C23H41N2O8PRS", "compartment": "c", "id": "tddec2eACP_c"}, {"name": "(R)-3-hydroxy-cis-dodec-5-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hcddec5eACP_c"]}, "charge": -1, "formula": "C23H41N2O9PRS", "compartment": "c", "id": "3hcddec5eACP_c"}, {"name": "Trans-3-cis-5-dodecenoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["t3c5ddeceACP_c"]}, "charge": -1, "formula": "C23H39N2O8PRS", "compartment": "c", "id": "t3c5ddeceACP_c"}, {"name": "(R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hmrsACP_c"]}, "charge": -1, "formula": "C25H47N2O9PRS", "compartment": "c", "id": "3hmrsACP_c"}, {"name": "Trans-Tetradec-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["tmrs2eACP_c"]}, "charge": -1, "formula": "C25H45N2O8PRS", "compartment": "c", "id": "tmrs2eACP_c"}, {"name": "(R)-3-hydroxy-cis-myristol-7-eoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hcmrs7eACP_c"]}, "charge": -1, "formula": "C25H45N2O9PRS", "compartment": "c", "id": "3hcmrs7eACP_c"}, {"name": "Trans-3-cis-7-myristoleoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["t3c7mrseACP_c"]}, "charge": -1, "formula": "C25H43N2O8PRS", "compartment": "c", "id": "t3c7mrseACP_c"}, {"name": "Trans-Hexadec-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["tpalm2eACP_c"]}, "charge": -1, "formula": "C27H49N2O8PRS", "compartment": "c", "id": "tpalm2eACP_c"}, {"name": "R-3-hydroxypalmitoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hpalmACP_c"]}, "charge": -1, "formula": "C27H51N2O9PRS", "compartment": "c", "id": "3hpalmACP_c"}, {"name": "Trans-3-cis-9-palmitoleoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["t3c9palmeACP_c"]}, "charge": -1, "formula": "C27H47N2O8PRS", "compartment": "c", "id": "t3c9palmeACP_c"}, {"name": "(R)-3-hydroxy-cis-palm-9-eoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hcpalm9eACP_c"]}, "charge": -1, "formula": "C27H49N2O9PRS", "compartment": "c", "id": "3hcpalm9eACP_c"}, {"name": "Trans-octadec-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["toctd2eACP_c"]}, "charge": -1, "formula": "C29H53N2O8PRS", "compartment": "c", "id": "toctd2eACP_c"}, {"name": "(R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hoctaACP_c"]}, "charge": -1, "formula": "C29H55N2O9PRS", "compartment": "c", "id": "3hoctaACP_c"}, {"name": "Trans-3-cis-11-vacceoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["t3c11vaceACP_c"]}, "charge": -1, "formula": "C29H51N2O8PRS", "compartment": "c", "id": "t3c11vaceACP_c"}, {"name": "(R)-3-hydroxy-cis-vacc-11-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hcvac11eACP_c"]}, "charge": -1, "formula": "C29H53N2O9PRS", "compartment": "c", "id": "3hcvac11eACP_c"}, {"name": "(3R)-3-Hydroxyacyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3haACP_c"]}, "charge": -1, "formula": "C15H27N2O9PRS", "compartment": "c", "id": "3haACP_c"}, {"name": "But-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["but2eACP_c"]}, "charge": -1, "formula": "C15H25N2O8PRS", "compartment": "c", "id": "but2eACP_c"}, {"name": "(R)-3-Hydroxyhexanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hhexACP_c"]}, "charge": -1, "formula": "C17H31N2O9PRS", "compartment": "c", "id": "3hhexACP_c"}, {"name": "Trans-Hex-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["thex2eACP_c"]}, "charge": -1, "formula": "C17H29N2O8PRS", "compartment": "c", "id": "thex2eACP_c"}, {"name": "(R)-3-Hydroxyoctanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3hoctACP_c"]}, "charge": -1, "formula": "C19H35N2O9PRS", "compartment": "c", "id": "3hoctACP_c"}, {"name": "Trans-Oct-2-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["toct2eACP_c"]}, "charge": -1, "formula": "C19H33N2O8PRS", "compartment": "c", "id": "toct2eACP_c"}, {"name": "3-Hydroxypropanoate", "notes": {"original_bigg_ids": ["3hpp_p"]}, "charge": -1, "formula": "C3H5O3", "compartment": "p", "id": "3hpp_p"}, {"name": "3-Hydroxypropanoate", "notes": {"original_bigg_ids": ["3hpp_c"]}, "charge": -1, "formula": "C3H5O3", "compartment": "c", "id": "3hpp_c"}, {"name": "3-Dehydro-L-gulonate", "notes": {"original_bigg_ids": ["3dhguln_c"]}, "charge": -1, "formula": "C6H9O7", "compartment": "c", "id": "3dhguln_c"}, {"name": "3-keto-L-gulonate-6-phosphate", "notes": {"original_bigg_ids": ["3dhgulnp_c"]}, "charge": -3, "formula": "C6H8O10P", "compartment": "c", "id": "3dhgulnp_c"}, {"name": "Phosphate", "notes": {"original_bigg_ids": ["pi_p"]}, "charge": -2, "formula": "HO4P", "compartment": "p", "id": "pi_p"}, {"name": "Uridine", "notes": {"original_bigg_ids": ["uri_p"]}, "charge": 0, "formula": "C9H12N2O6", "compartment": "p", "id": "uri_p"}, {"name": "Cytidine", "notes": {"original_bigg_ids": ["cytd_p"]}, "charge": 0, "formula": "C9H13N3O5", "compartment": "p", "id": "cytd_p"}, {"name": "Adenosine", "notes": {"original_bigg_ids": ["adn_p"]}, "charge": 0, "formula": "C10H13N5O4", "compartment": "p", "id": "adn_p"}, {"name": "Guanosine", "notes": {"original_bigg_ids": ["gsn_p"]}, "charge": 0, "formula": "C10H13N5O5", "compartment": "p", "id": "gsn_p"}, {"name": "3-Oxodecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3odecACP_c"]}, "charge": -1, "formula": "C21H37N2O9PRS", "compartment": "c", "id": "3odecACP_c"}, {"name": "3-Oxododecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3oddecACP_c"]}, "charge": -1, "formula": "C23H41N2O9PRS", "compartment": "c", "id": "3oddecACP_c"}, {"name": "3-oxo-cis-dodec-5-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ocddec5eACP_c"]}, "charge": -1, "formula": "C23H39N2O9PRS", "compartment": "c", "id": "3ocddec5eACP_c"}, {"name": "3-Oxotetradecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3omrsACP_c"]}, "charge": -1, "formula": "C25H45N2O9PRS", "compartment": "c", "id": "3omrsACP_c"}, {"name": "3-oxo-cis-myristol-7-eoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ocmrs7eACP_c"]}, "charge": -1, "formula": "C25H43N2O9PRS", "compartment": "c", "id": "3ocmrs7eACP_c"}, {"name": "3-Oxohexadecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3opalmACP_c"]}, "charge": -1, "formula": "C27H49N2O9PRS", "compartment": "c", "id": "3opalmACP_c"}, {"name": "3-oxo-cis-palm-9-eoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ocpalm9eACP_c"]}, "charge": -1, "formula": "C27H47N2O9PRS", "compartment": "c", "id": "3ocpalm9eACP_c"}, {"name": "3-Oxooctadecanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ooctdACP_c"]}, "charge": -1, "formula": "C29H53N2O9PRS", "compartment": "c", "id": "3ooctdACP_c"}, {"name": "3-oxo-cis-vacc-11-enoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ocvac11eACP_c"]}, "charge": -1, "formula": "C29H51N2O9PRS", "compartment": "c", "id": "3ocvac11eACP_c"}, {"name": "Acetoacetyl-ACP", "notes": {"original_bigg_ids": ["actACP_c"]}, "charge": -1, "formula": "C15H25N2O9PRS", "compartment": "c", "id": "actACP_c"}, {"name": "3-Oxohexanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ohexACP_c"]}, "charge": -1, "formula": "C17H29N2O9PRS", "compartment": "c", "id": "3ohexACP_c"}, {"name": "3-Oxooctanoyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["3ooctACP_c"]}, "charge": -1, "formula": "C19H33N2O9PRS", "compartment": "c", "id": "3ooctACP_c"}, {"name": "CO2", "notes": {"original_bigg_ids": ["co2_c"]}, "charge": 0, "formula": "CO2", "compartment": "c", "id": "co2_c"}, {"name": "Octanoyl-ACP (n-C8:0ACP)", "notes": {"original_bigg_ids": ["ocACP_c"]}, "charge": -1, "formula": "C19H35N2O8PRS", "compartment": "c", "id": "ocACP_c"}, {"name": "Malonyl-[acyl-carrier protein]", "notes": {"original_bigg_ids": ["malACP_c"]}, "charge": -2, "formula": "C14H22N2O10PRS", "compartment": "c", "id": "malACP_c"}, {"name": "Acyl carrier protein", "notes": {"original_bigg_ids": ["ACP_c"]}, "charge": -1, "formula": "C11H21N2O7PRS", "compartment": "c", "id": "ACP_c"}, {"name": "Decanoyl-ACP (n-C10:0ACP)", "notes": {"original_bigg_ids": ["dcaACP_c"]}, "charge": -1, "formula": "C21H39N2O8PRS", "compartment": "c", "id": "dcaACP_c"}, {"name": "Cis-dec-3-enoyl-[acyl-carrier protein] (n-C10:1)", "notes": {"original_bigg_ids": ["cdec3eACP_c"]}, "charge": -1, "formula": "C21H37N2O8PRS", "compartment": "c", "id": "cdec3eACP_c"}, {"name": "Dodecanoyl-ACP (n-C12:0ACP)", "notes": {"original_bigg_ids": ["ddcaACP_c"]}, "charge": -1, "formula": "C23H43N2O8PRS", "compartment": "c", "id": "ddcaACP_c"}, {"name": "Cis-dodec-5-enoyl-[acyl-carrier protein] (n-C12:1)", "notes": {"original_bigg_ids": ["cddec5eACP_c"]}, "charge": -1, "formula": "C23H41N2O8PRS", "compartment": "c", "id": "cddec5eACP_c"}, {"name": "Myristoyl-ACP (n-C14:0ACP)", "notes": {"original_bigg_ids": ["myrsACP_c"]}, "charge": -1, "formula": "C25H47N2O8PRS", "compartment": "c", "id": "myrsACP_c"}, {"name": "Cis-tetradec-7-enoyl-[acyl-carrier protein] (n-C14:1)", "notes": {"original_bigg_ids": ["tdeACP_c"]}, "charge": -1, "formula": "C25H45N2O8PRS", "compartment": "c", "id": "tdeACP_c"}, {"name": "Palmitoyl-ACP (n-C16:0ACP)", "notes": {"original_bigg_ids": ["palmACP_c"]}, "charge": -1, "formula": "C27H51N2O8PRS", "compartment": "c", "id": "palmACP_c"}, {"name": "Cis-hexadec-9-enoyl-[acyl-carrier protein] (n-C16:1)", "notes": {"original_bigg_ids": ["hdeACP_c"]}, "charge": -1, "formula": "C27H49N2O8PRS", "compartment": "c", "id": "hdeACP_c"}, {"name": "Butyryl-ACP (n-C4:0ACP)", "notes": {"original_bigg_ids": ["butACP_c"]}, "charge": -1, "formula": "C15H27N2O8PRS", "compartment": "c", "id": "butACP_c"}, {"name": "Hexanoyl-ACP (n-C6:0ACP)", "notes": {"original_bigg_ids": ["hexACP_c"]}, "charge": -1, "formula": 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"C131H231N2O60P3", "compartment": "c", "id": "hphhlipa_c"}, {"name": "4-Methyl-5-(2-phosphoethyl)-thiazole", "notes": {"original_bigg_ids": ["4mpetz_c"]}, "charge": -2, "formula": "C6H8NO4PS", "compartment": "c", "id": "4mpetz_c"}, {"name": "4-Methyl-5-(2-hydroxyethyl)-thiazole", "notes": {"original_bigg_ids": ["4mhetz_c"]}, "charge": 0, "formula": "C6H9NOS", "compartment": "c", "id": "4mhetz_c"}, {"name": "D-Mannose 6-phosphate", "notes": {"original_bigg_ids": ["man6p_c"]}, "charge": -2, "formula": "C6H11O9P", "compartment": "c", "id": "man6p_c"}, {"name": "Hg2+", "notes": {"original_bigg_ids": ["hg2_p"]}, "charge": 2, "formula": "Hg", "compartment": "p", "id": "hg2_p"}, {"name": "Hg2+", "notes": {"original_bigg_ids": ["hg2_c"]}, "charge": 2, "formula": "Hg", "compartment": "c", "id": "hg2_c"}, {"name": "L-Histidinol", "notes": {"original_bigg_ids": ["histd_c"]}, "charge": 1, "formula": "C6H12N3O", "compartment": "c", "id": "histd_c"}, {"name": "L-Histidinol phosphate", "notes": 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phosphatidylglycerol (n-C18:0)", "notes": {"original_bigg_ids": ["apg180_c"]}, "charge": -1, "formula": "C60H116O11P", "compartment": "c", "id": "apg180_c"}, {"name": "Acyl phosphatidylglycerol (n-C18:1)", "notes": {"original_bigg_ids": ["apg181_c"]}, "charge": -1, "formula": "C60H110O11P", "compartment": "c", "id": "apg181_c"}, {"name": "TRNA(Lys)", "notes": {"original_bigg_ids": ["trnalys_c"]}, "charge": 0, "formula": "R", "compartment": "c", "id": "trnalys_c"}, {"name": "L-Lysine-tRNA (Lys)", "notes": {"original_bigg_ids": ["lystrna_c"]}, "charge": 2, "formula": "C6H14N2OR", "compartment": "c", "id": "lystrna_c"}, {"name": "L-Lyxose", "notes": {"original_bigg_ids": ["lyx_DASH_L_c"]}, "charge": 0, "formula": "C5H10O5", "compartment": "c", "id": "lyx__L_c"}, {"name": "L-Xylulose", "notes": {"original_bigg_ids": ["xylu_DASH_L_c"]}, "charge": 0, "formula": "C5H10O5", "compartment": "c", "id": "xylu__L_c"}, {"name": "L-Lyxose", "notes": {"original_bigg_ids": ["lyx_DASH_L_p"]}, "charge": 0, "formula": "C5H10O5", "compartment": "p", "id": "lyx__L_p"}, {"name": "D-Mannitol 1-phosphate", "notes": {"original_bigg_ids": ["mnl1p_c"]}, "charge": -2, "formula": "C6H13O9P", "compartment": "c", "id": "mnl1p_c"}, {"name": "Malonyl-CoA methyl ester", "notes": {"original_bigg_ids": ["malcoame_c"]}, "charge": -4, "formula": "C25H36N7O19P3S", "compartment": "c", "id": "malcoame_c"}, {"name": "D-Malate", "notes": {"original_bigg_ids": ["mal_DASH_D_c"]}, "charge": -2, "formula": "C4H4O5", "compartment": "c", "id": "mal__D_c"}, {"name": "D-Malate", "notes": {"original_bigg_ids": ["mal_DASH_D_p"]}, "charge": -2, "formula": "C4H4O5", "compartment": "p", "id": "mal__D_p"}, {"name": "Acetyl-maltose", "notes": {"original_bigg_ids": ["acmalt_c"]}, "charge": 0, "formula": "C14H24O12", "compartment": "c", "id": "acmalt_c"}, {"name": "Maltopentaose", "notes": {"original_bigg_ids": ["maltpt_p"]}, "charge": 0, "formula": "C30H52O26", "compartment": "p", "id": "maltpt_p"}, {"name": "Maltotriose", "notes": {"original_bigg_ids": ["malttr_p"]}, "charge": 0, "formula": "C18H32O16", "compartment": "p", "id": "malttr_p"}, {"name": "Maltotetraose", "notes": {"original_bigg_ids": ["maltttr_p"]}, "charge": 0, "formula": "C24H42O21", "compartment": "p", "id": "maltttr_p"}, {"name": "Maltose", "notes": {"original_bigg_ids": ["malt_p"]}, "charge": 0, "formula": "C12H22O11", "compartment": "p", "id": "malt_p"}, {"name": "Maltose 6'-phosphate", "notes": {"original_bigg_ids": ["malt6p_c"]}, "charge": -2, "formula": "C12H21O14P", "compartment": "c", "id": "malt6p_c"}, {"name": "L-Malate", "notes": {"original_bigg_ids": ["mal_DASH_L_p"]}, "charge": -2, "formula": "C4H4O5", "compartment": "p", "id": "mal__L_p"}, {"name": "D-Mannose 6-phosphate", "notes": {"original_bigg_ids": ["man6p_p"]}, "charge": -2, "formula": "C6H11O9P", "compartment": "p", "id": "man6p_p"}, {"name": "D-Mannonate", "notes": {"original_bigg_ids": ["mana_c"]}, "charge": -1, "formula": "C6H11O7", "compartment": "c", "id": 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tetrapeptide murein units (uncrosslinked, middle of chain)", "notes": {"original_bigg_ids": ["murein5p4p_p"]}, "charge": -4, "formula": "C77H119N15O41", "compartment": "p", "id": "murein5p4p_p"}, {"name": "Two linked disacharide pentapeptide and tripeptide murein units (uncrosslinked, middle of chain)", "notes": {"original_bigg_ids": ["murein5p3p_p"]}, "charge": -4, "formula": "C74H114N14O40", "compartment": "p", "id": "murein5p3p_p"}, {"name": "Two linked disacharide tetrapeptide and tripeptide murein units (uncrosslinked, middle of chain)", "notes": {"original_bigg_ids": ["murein4p3p_p"]}, "charge": -4, "formula": "C71H109N13O39", "compartment": "p", "id": "murein4p3p_p"}, {"name": "Three disacharide linked murein units (tetrapeptide crosslinked tetrapeptide (A2pm->D-ala), one uncrosslinked tetrapaptide) (middle of chain)", "notes": {"original_bigg_ids": ["murein4px4p4p_p"]}, "charge": -6, "formula": "C111H169N21O59", "compartment": "p", "id": "murein4px4p4p_p"}, {"name": 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"Nitrite", "notes": {"original_bigg_ids": ["no2_c"]}, "charge": -1, "formula": "NO2", "compartment": "c", "id": "no2_c"}, {"name": "Nitrite", "notes": {"original_bigg_ids": ["no2_p"]}, "charge": -1, "formula": "NO2", "compartment": "p", "id": "no2_p"}, {"name": "Nitrate", "notes": {"original_bigg_ids": ["no3_p"]}, "charge": -1, "formula": "NO3", "compartment": "p", "id": "no3_p"}, {"name": "Nitrate", "notes": {"original_bigg_ids": ["no3_c"]}, "charge": -1, "formula": "NO3", "compartment": "c", "id": "no3_c"}, {"name": "Novobiocin", "notes": {"original_bigg_ids": ["novbcn_p"]}, "charge": 0, "formula": "C31H36N2O11", "compartment": "p", "id": "novbcn_p"}, {"name": "Nitric oxide", "notes": {"original_bigg_ids": ["no_p"]}, "charge": 0, "formula": "NO", "compartment": "p", "id": "no_p"}, {"name": "Xanthosine", "notes": {"original_bigg_ids": ["xtsn_c"]}, "charge": 0, "formula": "C10H12N4O6", "compartment": "c", "id": "xtsn_c"}, {"name": "Xanthosine", "notes": {"original_bigg_ids": ["xtsn_p"]}, "charge": 0, "formula": "C10H12N4O6", "compartment": "p", "id": "xtsn_p"}, {"name": "Xanthosine 5'-phosphate", "notes": {"original_bigg_ids": ["xmp_p"]}, "charge": -2, "formula": "C10H11N4O9P", "compartment": "p", "id": "xmp_p"}, {"name": "DIMP", "notes": {"original_bigg_ids": ["dimp_c"]}, "charge": -2, "formula": "C10H11N4O7P", "compartment": "c", "id": "dimp_c"}, {"name": "UMP", "notes": {"original_bigg_ids": ["ump_p"]}, "charge": -2, "formula": "C9H11N2O9P", "compartment": "p", "id": "ump_p"}, {"name": "Thymidine", "notes": {"original_bigg_ids": ["thymd_c"]}, "charge": 0, "formula": "C10H14N2O5", "compartment": "c", "id": "thymd_c"}, {"name": "Thymidine", "notes": {"original_bigg_ids": ["thymd_p"]}, "charge": 0, "formula": "C10H14N2O5", "compartment": "p", "id": "thymd_p"}, {"name": "DIDP", "notes": {"original_bigg_ids": ["didp_c"]}, "charge": -3, "formula": "C10H11N4O10P2", "compartment": "c", "id": "didp_c"}, {"name": "XDP", "notes": {"original_bigg_ids": ["xdp_c"]}, 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["o16aund_c"]}, "charge": -2, "formula": "C89H145N1O32P2", "compartment": "c", "id": "o16aund_c"}, {"name": "Superoxide anion", "notes": {"original_bigg_ids": ["o2s_p"]}, "charge": -1, "formula": "O2", "compartment": "p", "id": "o2s_p"}, {"name": "3-Hydroxyglutaryl-[acyl-carrier protein] methyl ester", "notes": {"original_bigg_ids": ["hgmeACP_c"]}, "charge": -1, "formula": "C17H29N2O11PRS", "compartment": "c", "id": "hgmeACP_c"}, {"name": "3-Oxo-glutaryl-[acyl-carrier protein] methyl ester", "notes": {"original_bigg_ids": ["ogmeACP_c"]}, "charge": -1, "formula": "C17H27N2O11PRS", "compartment": "c", "id": "ogmeACP_c"}, {"name": "2-Oxo-3-hydroxy-4-phosphobutanoate", "notes": {"original_bigg_ids": ["ohpb_c"]}, "charge": -3, "formula": "C4H4O8P", "compartment": "c", "id": "ohpb_c"}, {"name": "2-Octaprenyl-6-methoxyphenol", "notes": {"original_bigg_ids": ["2omph_c"]}, "charge": 0, "formula": "C47H72O2", "compartment": "c", "id": "2omph_c"}, {"name": "2-Octaprenyl-3-methyl-6-methoxy- 1,4-benzoquinol", "notes": {"original_bigg_ids": ["2ommbl_c"]}, "charge": 0, "formula": "C48H74O3", "compartment": "c", "id": "2ommbl_c"}, {"name": "2-Octaprenyl-6-methoxy-1,4-benzoquinol", "notes": {"original_bigg_ids": ["2ombzl_c"]}, "charge": 0, "formula": "C47H72O3", "compartment": "c", "id": "2ombzl_c"}, {"name": "Orotidine 5'-phosphate", "notes": {"original_bigg_ids": ["orot5p_c"]}, "charge": -3, "formula": "C10H10N2O11P", "compartment": "c", "id": "orot5p_c"}, {"name": "2-Octaprenylphenol", "notes": {"original_bigg_ids": ["2oph_c"]}, "charge": 0, "formula": "C46H70O", "compartment": "c", "id": "2oph_c"}, {"name": "3-Hydroxypimeloyl-[acyl-carrier protein] methyl ester", "notes": {"original_bigg_ids": ["hpmeACP_c"]}, "charge": -1, "formula": "C19H33N2O11PRS", "compartment": "c", "id": "hpmeACP_c"}, {"name": "3-Oxo-pimeloyl-[acyl-carrier protein] methyl ester", "notes": {"original_bigg_ids": ["opmeACP_c"]}, "charge": -1, "formula": "C19H31N2O11PRS", "compartment": "c", "id": "opmeACP_c"}, {"name": "Orotate", "notes": {"original_bigg_ids": ["orot_p"]}, "charge": -1, "formula": "C5H3N2O4", "compartment": "p", "id": "orot_p"}, {"name": "Oxalureate", "notes": {"original_bigg_ids": ["oxur_c"]}, "charge": -1, "formula": "C3H3N2O4", "compartment": "c", "id": "oxur_c"}, {"name": "Phenylacetaldehyde", "notes": {"original_bigg_ids": ["pacald_c"]}, "charge": 0, "formula": "C8H8O", "compartment": "c", "id": "pacald_c"}, {"name": "Phenylacetaldehyde", "notes": {"original_bigg_ids": ["pacald_p"]}, "charge": 0, "formula": "C8H8O", "compartment": "p", "id": "pacald_p"}, {"name": "(R)-Pantothenate", "notes": {"original_bigg_ids": ["pnto_DASH_R_c"]}, "charge": -1, "formula": "C9H16NO5", "compartment": "c", "id": "pnto__R_c"}, {"name": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine", "notes": {"original_bigg_ids": ["ugmda_c"]}, "charge": -4, "formula": "C41H61N9O28P2", "compartment": "c", "id": "ugmda_c"}, {"name": "Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine", "notes": {"original_bigg_ids": ["uagmda_c"]}, "charge": -4, "formula": "C87H139N7O23P2", "compartment": "c", "id": "uagmda_c"}, {"name": "Pyridoxine 5'-phosphate", "notes": {"original_bigg_ids": ["pdx5p_c"]}, "charge": -2, "formula": "C8H10NO6P", "compartment": "c", "id": "pdx5p_c"}, {"name": "Pyridoxine", "notes": {"original_bigg_ids": ["pydxn_c"]}, "charge": 0, "formula": "C8H11NO3", "compartment": "c", "id": "pydxn_c"}, {"name": "Phosphatidylethanolamine (didodecanoyl, n-C12:0)", "notes": {"original_bigg_ids": ["pe120_p"]}, "charge": 0, "formula": "C29H58N1O8P1", "compartment": "p", "id": "pe120_p"}, {"name": "Phosphatidylethanolamine (ditetradecanoyl, n-C14:0)", "notes": {"original_bigg_ids": ["pe140_p"]}, "charge": 0, "formula": "C33H66N1O8P1", "compartment": "p", "id": "pe140_p"}, {"name": "Phosphatidylethanolamine (ditetradec-7-enoyl, n-C14:1)", "notes": 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"charge": -3, "formula": "C2H2O6P", "compartment": "c", "id": "2pglyc_c"}, {"name": "Phosphatidylglycerophosphate (didodecanoyl, n-C12:0)", "notes": {"original_bigg_ids": ["pgp120_p"]}, "charge": -3, "formula": "C30H57O13P2", "compartment": "p", "id": "pgp120_p"}, {"name": "Phosphatidylglycerophosphate (didodecanoyl, n-C12:0)", "notes": {"original_bigg_ids": ["pgp120_c"]}, "charge": -3, "formula": "C30H57O13P2", "compartment": "c", "id": "pgp120_c"}, {"name": "Phosphatidylglycerophosphate (ditetradecanoyl, n-C14:0)", "notes": {"original_bigg_ids": ["pgp140_p"]}, "charge": -3, "formula": "C34H65O13P2", "compartment": "p", "id": "pgp140_p"}, {"name": "Phosphatidylglycerophosphate (ditetradecanoyl, n-C14:0)", "notes": {"original_bigg_ids": ["pgp140_c"]}, "charge": -3, "formula": "C34H65O13P2", "compartment": "c", "id": "pgp140_c"}, {"name": "Phosphatidylglycerophosphate (ditetradec-7-enoyl, n-C14:1)", "notes": {"original_bigg_ids": ["pgp141_c"]}, "charge": -3, "formula": "C34H61O13P2", "compartment": "c", "id": "pgp141_c"}, {"name": "Phosphatidylglycerophosphate (ditetradec-7-enoyl, n-C14:1)", "notes": {"original_bigg_ids": ["pgp141_p"]}, "charge": -3, "formula": "C34H61O13P2", "compartment": "p", "id": "pgp141_p"}, {"name": "Phosphatidylglycerophosphate (dihexadecanoyl, n-C16:0)", "notes": {"original_bigg_ids": ["pgp160_c"]}, "charge": -3, "formula": "C38H73O13P2", "compartment": "c", "id": "pgp160_c"}, {"name": "Phosphatidylglycerophosphate (dihexadecanoyl, n-C16:0)", "notes": {"original_bigg_ids": ["pgp160_p"]}, "charge": -3, "formula": "C38H73O13P2", "compartment": "p", "id": "pgp160_p"}, {"name": "Phosphatidylglycerophosphate (dihexadec-9-enoyl, n-C16:1)", "notes": {"original_bigg_ids": ["pgp161_c"]}, "charge": -3, "formula": "C38H69O13P2", "compartment": "c", "id": "pgp161_c"}, {"name": "Phosphatidylglycerophosphate (dihexadec-9-enoyl, n-C16:1)", "notes": {"original_bigg_ids": ["pgp161_p"]}, "charge": -3, "formula": "C38H69O13P2", "compartment": "p", "id": "pgp161_p"}, {"name": "Phosphatidylglycerophosphate (dioctadecanoyl, n-C18:0)", "notes": {"original_bigg_ids": ["pgp180_p"]}, "charge": -3, "formula": "C42H81O13P2", "compartment": "p", "id": "pgp180_p"}, {"name": "Phosphatidylglycerophosphate (dioctadecanoyl, n-C18:0)", "notes": {"original_bigg_ids": ["pgp180_c"]}, "charge": -3, "formula": "C42H81O13P2", "compartment": "c", "id": "pgp180_c"}, {"name": "Phosphatidylglycerophosphate (dioctadec-11-enoyl, n-C18:1)", "notes": {"original_bigg_ids": ["pgp181_p"]}, "charge": -3, "formula": "C42H77O13P2", "compartment": "p", "id": "pgp181_p"}, {"name": "Phosphatidylglycerophosphate (dioctadec-11-enoyl, n-C18:1)", "notes": {"original_bigg_ids": ["pgp181_c"]}, "charge": -3, "formula": "C42H77O13P2", "compartment": "c", "id": "pgp181_c"}, {"name": "Protoheme", "notes": {"original_bigg_ids": ["pheme_p"]}, "charge": -2, "formula": "C34H30FeN4O4", "compartment": "p", "id": "pheme_p"}, {"name": "Phenylpyruvate", "notes": {"original_bigg_ids": ["phpyr_c"]}, "charge": -1, "formula": "C9H7O3", "compartment": "c", "id": "phpyr_c"}, {"name": "L-Phenylalanine", "notes": {"original_bigg_ids": ["phe_DASH_L_p"]}, "charge": 0, "formula": "C9H11NO2", "compartment": "p", "id": "phe__L_p"}, {"name": "4-(1-D-Ribitylamino)-5-aminouracil", "notes": {"original_bigg_ids": ["4r5au_c"]}, "charge": 0, "formula": "C9H16N4O6", "compartment": "c", "id": "4r5au_c"}, {"name": "D-4'-Phosphopantothenate", "notes": {"original_bigg_ids": ["4ppan_c"]}, "charge": -3, "formula": "C9H15NO8P", "compartment": "c", "id": "4ppan_c"}, {"name": "(R)-Pantothenate", "notes": {"original_bigg_ids": ["pnto_DASH_R_p"]}, "charge": -1, "formula": "C9H16NO5", "compartment": "p", "id": "pnto__R_p"}, {"name": "Peroxyaminoacrylate", "notes": {"original_bigg_ids": ["poaac_c"]}, "charge": 0, "formula": "C3H5NO3", "compartment": "c", "id": "poaac_c"}, {"name": "Propanoyl phosphate", "notes": {"original_bigg_ids": ["ppap_c"]}, "charge": -2, "formula": "C3H5O5P", "compartment": 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{"original_bigg_ids": ["pppn_p"]}, "charge": -1, "formula": "C9H9O2", "compartment": "p", "id": "pppn_p"}, {"name": "Phenylpropanoate", "notes": {"original_bigg_ids": ["pppn_c"]}, "charge": -1, "formula": "C9H9O2", "compartment": "c", "id": "pppn_c"}, {"name": "Phosphonate", "notes": {"original_bigg_ids": ["ppt_p"]}, "charge": -2, "formula": "HO3P", "compartment": "p", "id": "ppt_p"}, {"name": "2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine", "notes": {"original_bigg_ids": ["fpram_c"]}, "charge": -1, "formula": "C8H15N3O8P", "compartment": "c", "id": "fpram_c"}, {"name": "1-(5-Phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide", "notes": {"original_bigg_ids": ["prfp_c"]}, "charge": -4, "formula": "C15H21N5O15P2", "compartment": "c", "id": "prfp_c"}, {"name": "1-(5-Phosphoribosyl)-AMP", "notes": {"original_bigg_ids": ["prbamp_c"]}, "charge": -4, "formula": "C15H19N5O14P2", "compartment": "c", "id": "prbamp_c"}, {"name": "L-Prolinylglycine", "notes": 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"compartment": "p", "id": "salchs4_p"}, {"name": "2-Aminoethylphosphonate", "notes": {"original_bigg_ids": ["AEP_e"]}, "charge": -1, "formula": "C2H7N1O3P1", "compartment": "e", "id": "AEP_e"}, {"name": "Oxaloacetate", "notes": {"original_bigg_ids": ["oaa_p"]}, "charge": -2, "formula": "C4H2O5", "compartment": "p", "id": "oaa_p"}, {"name": "Tetrathionate", "notes": {"original_bigg_ids": ["tet_p"]}, "charge": -2, "formula": "O6S4", "compartment": "p", "id": "tet_p"}, {"name": "Pseudouridine 5  phosphate C9H11N2O9P", "notes": {"original_bigg_ids": ["psd5p_c"]}, "charge": -2, "formula": "C9H13N2O9P", "compartment": "c", "id": "psd5p_c"}, {"name": "O-antigen-x20-core-oligosaccharide-lipid-A", "notes": {"original_bigg_ids": ["colipa20Oag_e"]}, "charge": -11, "formula": "C656H1103N2O440P4", "compartment": "e", "id": "colipa20Oag_e"}, {"name": "D-biotin d-sulfoxide", "notes": {"original_bigg_ids": ["btnso_c"]}, "charge": -1, "formula": "C10H15N2O4S", "compartment": "c", "id": "btnso_c"}, {"name": "2-3-dihydroxybenzoylserine trimer", "notes": {"original_bigg_ids": ["23dhbzs3_c"]}, "charge": 0, "formula": "C30H29N3O16", "compartment": "c", "id": "23dhbzs3_c"}, {"name": "Residual-atoms-of-reaction-DMBZIDSYN", "notes": {"original_bigg_ids": ["remnant1_e"]}, "charge": 0, "formula": "C4H2N2O3", "compartment": "e", "id": "remnant1_e"}, {"name": "D-Tagatose", "notes": {"original_bigg_ids": ["tag_DASH_D_p"]}, "charge": 0, "formula": "C6H12O6", "compartment": "p", "id": "tag__D_p"}, {"name": "N Ribosylnicotinamide C11H15N2O5", "notes": {"original_bigg_ids": ["rnam_e"]}, "charge": 1, "formula": "C11H15N2O5", "compartment": "e", "id": "rnam_e"}, {"name": "Cis-Aconitate", "notes": {"original_bigg_ids": ["acon_DASH_C_p"]}, "charge": -3, "formula": "C6H3O6", "compartment": "p", "id": "acon_C_p"}, {"name": "Adenosylcobalamin-phosphate", "notes": {"original_bigg_ids": ["adocblp_c"]}, "charge": -2, "formula": "C72H99CoN18O20P2", "compartment": "c", "id": "adocblp_c"}, {"name": "Cobalt-precorrin-2", "notes": {"original_bigg_ids": ["codscl2_c"]}, "charge": -7, "formula": "C42H39CoN4O16", "compartment": "c", "id": "codscl2_c"}, {"name": "Aminoimidazole-riboside", "notes": {"original_bigg_ids": ["airs_e"]}, "charge": 0, "formula": "C8H13N3O4", "compartment": "e", "id": "airs_e"}, {"name": "2-Aminoethylphosphonate", "notes": {"original_bigg_ids": ["AEP_p"]}, "charge": -1, "formula": "C2H7N1O3P1", "compartment": "p", "id": "AEP_p"}, {"name": "Salmochelin-S2-Fe-III", "notes": {"original_bigg_ids": ["salchs2fe_p"]}, "charge": 0, "formula": "C42FeH49N3O26", "compartment": "p", "id": "salchs2fe_p"}, {"name": "Undecaprenyl diphosphate galactose-rhamnose-mannose-abequose", "notes": {"original_bigg_ids": ["udcpo4_e"]}, "charge": -2, "formula": "C79H132O24P2", "compartment": "e", "id": "udcpo4_e"}, {"name": "Ferrioxamine-G-fe", "notes": {"original_bigg_ids": ["feroxGfe_e"]}, "charge": 0, "formula": "C27H46FeN6O10", "compartment": "e", "id": "feroxGfe_e"}, {"name": "Salmochelin-S2-Fe-III", "notes": {"original_bigg_ids": ["salchs2fe_c"]}, "charge": 0, "formula": "C42FeH49N3O26", "compartment": "c", "id": "salchs2fe_c"}, {"name": "Undecaprenyl diphosphate galactose-rhamnose-mannose-abequose-acetyl", "notes": {"original_bigg_ids": ["udcpo5_e"]}, "charge": -2, "formula": "C81H134O25P2", "compartment": "e", "id": "udcpo5_e"}, {"name": "Ferrioxamine-G", "notes": {"original_bigg_ids": ["feroxG_e"]}, "charge": 0, "formula": "C27H46N6O10", "compartment": "e", "id": "feroxG_e"}, {"name": "Formamide", "notes": {"original_bigg_ids": ["foam_p"]}, "charge": 0, "formula": "CH3NO", "compartment": "p", "id": "foam_p"}, {"name": "4-Hydroxy-benzyl alcohol", "notes": {"original_bigg_ids": ["4hba_c"]}, "charge": 0, "formula": "C7H8O2", "compartment": "c", "id": "4hba_c"}, {"notes": {"original_bigg_ids": ["diact_e"]}, "compartment": "e", "name": "Diacetyl", "charge": 0, "id": "diact_e"}, {"notes": {"original_bigg_ids": ["indpyr_c"]}, "compartment": "c", "name": "Indolepyruvate C11H8NO3", "charge": 0, "id": "indpyr_c"}, {"notes": {"original_bigg_ids": ["pprdn_c"]}, "compartment": "c", "name": "Piperideine", "charge": 0, "id": "pprdn_c"}, {"notes": {"original_bigg_ids": ["5aptn_c"]}, "compartment": "c", "name": "5-Aminopentanoate", "charge": 0, "id": "5aptn_c"}, {"notes": {"original_bigg_ids": ["glutar_c"]}, "compartment": "c", "name": "Glutarate", "charge": 0, "id": "glutar_c"}, {"notes": {"original_bigg_ids": ["oxptn_c"]}, "compartment": "c", "name": "5-Oxopentanoate", "charge": 0, "id": "oxptn_c"}, {"notes": {"original_bigg_ids": ["btd_DASH_RR_e"]}, "compartment": "e", "name": " R R  2 3 Butanediol C4H10O2", "charge": 0, "id": "btd_RR_e"}, {"notes": {"original_bigg_ids": ["13ppd_e"]}, "compartment": "e", "name": "1,3-Propanediol", "charge": 0, "id": "13ppd_e"}, {"notes": {"original_bigg_ids": ["rbt_e"]}, "compartment": "e", "name": "Ribitol", "charge": 0, "id": "rbt_e"}, {"notes": {"original_bigg_ids": ["cellb_e"]}, "compartment": "e", "name": "Cellobiose", "charge": 0, "id": "cellb_e"}, {"notes": {"original_bigg_ids": ["bz_e"]}, "compartment": "e", "name": "Benzoate", "charge": 0, "id": "bz_e"}, {"name": "3-Oxoadipyl-CoA", "notes": {"original_bigg_ids": ["oxadpcoa_c"]}, "charge": -5, "formula": "C27H37N7O20P3S", "compartment": "c", "id": "oxadpcoa_c"}, {"notes": {"original_bigg_ids": ["glutcoa_c"]}, "compartment": "c", "name": "Glutaryl-CoA", "charge": 0, "id": "glutcoa_c"}, {"notes": {"original_bigg_ids": ["abt_DASH_D_e"]}, "compartment": "e", "name": "D-Arabitol", "charge": 0, "id": "abt__D_e"}, {"notes": {"original_bigg_ids": ["4hphac_c"]}, "compartment": "c", "name": "4-Hydroxyphenylacetate", "charge": 0, "id": "4hphac_c"}, {"name": "4-Hydroxyphenylacetate", "notes": {"original_bigg_ids": ["4hphac_p"]}, "charge": -1, "formula": "C8H7O3", "compartment": "p", "id": "4hphac_p"}, {"name": "Cyanate", "notes": {"original_bigg_ids": ["cynt_c"]}, "charge": -1, "formula": "CNO", "compartment": "c", "id": "cynt_c"}, {"name": "S-Methyl-L-methionine", "notes": {"original_bigg_ids": ["mmet_c"]}, "charge": 1, "formula": "C6H14NO2S", "compartment": "c", "id": "mmet_c"}, {"name": "Salicylate", "notes": {"original_bigg_ids": ["salc_c"]}, "charge": 0, "formula": "C7H5O3", "compartment": "c", "id": "salc_c"}, {"name": "2(alpha-D-Mannosyl-6-phosphate)-D-glycerate", "notes": {"original_bigg_ids": ["man6pglyc_c"]}, "charge": -3, "formula": "C9H14O12P", "compartment": "c", "id": "man6pglyc_c"}, {"name": "Fe p", "notes": {"original_bigg_ids": ["fe_p"]}, "charge": 0, "formula": "Fe", "compartment": "p", "id": "fe_p"}, {"name": "Fe p", "notes": {"original_bigg_ids": ["fe_e"]}, "charge": 0, "formula": "Fe", "compartment": "e", "id": "fe_e"}, {"name": "Fe p", "notes": {"original_bigg_ids": ["fe_c"]}, "charge": 0, "formula": "Fe", "compartment": "c", "id": "fe_c"}, {"name": "Psicoselysine", "notes": {"original_bigg_ids": ["psclys_c"]}, "charge": 1, "formula": "C12H25N2O7", "compartment": "c", "id": "psclys_c"}, {"name": "3-(3-hydroxy-phenyl)propionate", "notes": {"original_bigg_ids": ["3hpppn_c"]}, "charge": -1, "formula": "C9H9O3", "compartment": "c", "id": "3hpppn_c"}, {"name": "3-hydroxycinnamic acid", "notes": {"original_bigg_ids": ["3hcinnm_c"]}, "charge": -1, "formula": "C9H7O3", "compartment": "c", "id": "3hcinnm_c"}, {"name": "KO-KDO-LIPID A", "notes": {"original_bigg_ids": ["kokdolipidA_e"]}, "charge": 0, "formula": "C110H196N2O40P2", "compartment": "e", "id": "kokdolipidA_e"}, {"name": "D Galactosamine 6 phosphate C6H14NO8P", "notes": {"original_bigg_ids": ["galam6p_c"]}, "charge": 0, "formula": "C6H14NO8P", "compartment": "c", "id": "galam6p_c"}, {"name": "2-(Hydroxymethyl)phenol", "notes": {"original_bigg_ids": ["2hymeph_c"]}, "charge": 0, "formula": "C7H8O2", "compartment": "c", "id": "2hymeph_c"}, {"name": "Salicin", "notes": {"original_bigg_ids": ["salcn_c"]}, "charge": 0, "formula": "C13H18O7", "compartment": "c", "id": "salcn_c"}, {"name": "Cellobiose", "notes": {"original_bigg_ids": ["cellb_p"]}, "charge": 0, "formula": "C12H22O11", "compartment": "p", "id": "cellb_p"}, {"name": "3 Hydroxyphenylacetic acid C8H8O3", "notes": {"original_bigg_ids": ["3hoxpac_e"]}, "charge": 0, "formula": "C8H8O3", "compartment": "e", "id": "3hoxpac_e"}, {"name": "Penicillin G C16H18N2O4S", "notes": {"original_bigg_ids": ["peng_p"]}, "charge": 0, "formula": "C16H18N2O4S", "compartment": "p", "id": "peng_p"}, {"name": "Penicillin G C16H18N2O4S", "notes": {"original_bigg_ids": ["peng_e"]}, "charge": 0, "formula": "C16H18N2O4S", "compartment": "e", "id": "peng_e"}, {"name": " O6 antigen x4 core oligosaccharide lipid A O225H390N2O120P2", "notes": {"original_bigg_ids": ["o6a4colipa_e"]}, "charge": 0, "formula": "O225H390N2O120P2", "compartment": "e", "id": "o6a4colipa_e"}, {"name": "UDP-N-acetyl-D-galactosamine", "notes": {"original_bigg_ids": ["udpacgal_c"]}, "charge": 0, "formula": "C17H25N3O17P2", "compartment": "c", "id": "udpacgal_c"}, {"name": "D Galactosamine C6H13NO5", "notes": {"original_bigg_ids": ["galam_p"]}, "charge": 0, "formula": "C6H13NO5", "compartment": "p", "id": "galam_p"}, {"name": "R1 glucosyl glucosyl inner core oligosaccharide lipid A with laurate C141H226N2O73P4", "notes": {"original_bigg_ids": ["ggicolipaBR1_c"]}, "charge": 0, "formula": "C141H226N2O73P4", "compartment": "c", "id": "ggicolipaBR1_c"}, {"name": "R1 glucosyl inner core oligosaccharide lipid A with laurate C135H216N2O68P4", "notes": {"original_bigg_ids": ["gicolipaBR1_c"]}, "charge": 0, "formula": "C135H216N2O68P4", "compartment": "c", "id": "gicolipaBR1_c"}, {"name": "3 Hydroxyphenylacetic acid C8H8O3", "notes": {"original_bigg_ids": ["3hoxpac_p"]}, "charge": 0, "formula": "C8H8O3", "compartment": "p", "id": "3hoxpac_p"}, {"name": "6 Aminopenicillanic acid C8H12N2O3S", "notes": {"original_bigg_ids": ["6apa_e"]}, "charge": 0, "formula": "C8H12N2O3S", "compartment": "e", "id": "6apa_e"}, {"name": "6 Aminopenicillanic acid C8H12N2O3S", "notes": {"original_bigg_ids": ["6apa_p"]}, "charge": 0, "formula": "C8H12N2O3S", "compartment": "p", "id": "6apa_p"}, {"name": "(R)-Methylmalonyl-CoA", "notes": {"original_bigg_ids": ["mmcoa_R_c"]}, "charge": 0, "formula": "C25H35N7O19P3S", "compartment": "c", "id": "mmcoa__R_c"}, {"name": "D Galactosamine C6H13NO5", "notes": {"original_bigg_ids": ["galam_e"]}, "charge": 0, "formula": "C6H13NO5", "compartment": "e", "id": "galam_e"}, {"name": "R1 galactosyl glucosyl glucosyl glucosyl inner core oligosaccharide lipid A with laurate C153H246N2O83P4", "notes": {"original_bigg_ids": ["gagggicolipaBR1_c"]}, "charge": 0, "formula": "C153H246N2O83P4", "compartment": "c", "id": "gagggicolipaBR1_c"}, {"name": "Core oligosaccharide lipid A with laurate C159H256N2O88P4", "notes": {"original_bigg_ids": ["colipaB_c"]}, "charge": 0, "formula": "C159H256N2O88P4", "compartment": "c", "id": "colipaB_c"}, {"name": "R1 glucosyl glucosyl glucosyl inner core oligosaccharide lipid A with laurate C147H236N2O78P4", "notes": {"original_bigg_ids": ["gggicolipaBR1_c"]}, "charge": 0, "formula": "C147H236N2O78P4", "compartment": "c", "id": "gggicolipaBR1_c"}, {"name": "Heptosyl phospho heptosyl heptosyl kdo2 lipidA with laurate C122H195N2O54P3", "notes": {"original_bigg_ids": ["hphhlipaB_c"]}, "charge": 0, "formula": "C122H195N2O54P3", "compartment": "c", "id": "hphhlipaB_c"}, {"name": "R1 inner core oligosaccharide lipid A  E coli  with laurate C129H206N2O63P4", "notes": {"original_bigg_ids": ["icolipaBR1_c"]}, "charge": 0, "formula": "C129H206N2O63P4", "compartment": "c", "id": "icolipaBR1_c"}, {"name": "1' Phosphoethanolamin lipidIVa C70H132N3O26P3", "notes": {"original_bigg_ids": ["enlipidA_p"]}, "charge": 0, "formula": "C70H132N3O26P3", "compartment": "p", "id": "enlipidA_p"}, {"notes": {"original_bigg_ids": ["LptA_p"]}, "compartment": "p", "name": "Periplasmic lipid A binding protein ", "charge": 0, "id": "LptA_p"}, {"name": "1' Phosphoethanolamin lipidIVa C70H132N3O26P3", "notes": {"original_bigg_ids": ["enlipidA_LptA_p"]}, "charge": 0, "formula": "C70H132N3O26P3", "compartment": "p", "id": "enlipidA_LptA_p"}, {"name": "3 Nitrotyramine C8H15N2", "notes": {"original_bigg_ids": ["3ntym_e"]}, "charge": 0, "formula": "C8H15N2", "compartment": "e", "id": "3ntym_e"}, {"name": "Salicin", "notes": {"original_bigg_ids": ["salcn_p"]}, "charge": 0, "formula": "C13H18O7", "compartment": "p", "id": "salcn_p"}, {"name": "Salicin", "notes": {"original_bigg_ids": ["salcn_e"]}, "charge": 0, "formula": "C13H18O7", "compartment": "e", "id": "salcn_e"}, {"name": "Cellobiose 6 phosphate C12H21O14P", "notes": {"original_bigg_ids": ["cellb6p_c"]}, "charge": 0, "formula": "C12H21O14P", "compartment": "c", "id": "cellb6p_c"}, {"name": "1' Phosphoethanolamin lipidIVa C70H132N3O26P3", "notes": {"original_bigg_ids": ["enlipidA_e"]}, "charge": 0, "formula": "C70H132N3O26P3", "compartment": "e", "id": "enlipidA_e"}, {"name": "4 Hydroxyphenylacetic acid C8H8O3", "notes": {"original_bigg_ids": ["4hoxpac_e"]}, "charge": 0, "formula": "C8H8O3", "compartment": "e", "id": "4hoxpac_e"}, {"name": "Phenylacetic acid", "notes": {"original_bigg_ids": ["pac_e"]}, "charge": 0, "formula": "C8H7O2", "compartment": "e", "id": "pac_e"}, {"name": "N Acetyl D galactosamine 6 phosphate C8H16NO9P", "notes": {"original_bigg_ids": ["acgal6p_c"]}, "charge": 0, "formula": "C8H16NO9P", "compartment": "c", "id": "acgal6p_c"}, {"name": "Salicin 6 phosphate C13H19O10P", "notes": {"original_bigg_ids": ["salcn6p_c"]}, "charge": 0, "formula": "C13H19O10P", "compartment": "c", "id": "salcn6p_c"}, {"name": "Heptosyl phospho heptosyl heptosyl kdo2 lipidA C131H211N2O60P3", "notes": {"original_bigg_ids": ["hphhlipaA_c"]}, "charge": 0, "formula": "C131H211N2O60P3", "compartment": "c", "id": "hphhlipaA_c"}, {"name": "R1 inner core oligosaccharide lipid A  E coli  C131H210N2O63P4", "notes": {"original_bigg_ids": ["icolipaAR1_c"]}, "charge": 0, "formula": "C131H210N2O63P4", "compartment": "c", "id": "icolipaAR1_c"}, {"name": "R1 glucosyl glucosyl inner core oligosaccharide lipid A C143H230N2O73P4", "notes": {"original_bigg_ids": ["ggicolipaAR1_c"]}, "charge": 0, "formula": "C143H230N2O73P4", "compartment": "c", "id": "ggicolipaAR1_c"}, {"name": "R1 glucosyl inner core oligosaccharide lipid A C137H220N2O68P4", "notes": {"original_bigg_ids": ["gicolipaAR1_c"]}, "charge": 0, "formula": "C137H220N2O68P4", "compartment": "c", "id": "gicolipaAR1_c"}, {"name": "Cellobiose", "notes": {"original_bigg_ids": ["cellb_c"]}, "charge": 0, "formula": "C12H22O11", "compartment": "c", "id": "cellb_c"}, {"name": "Raffinose C18H32O16", "notes": {"original_bigg_ids": ["raffin_e"]}, "charge": 0, "formula": "C18H32O16", "compartment": "e", "id": "raffin_e"}, {"name": "2 3 2'3' Tetrakis beta hydroxymyristoyl  D glucosaminyl 1 6 beta D glucosamine 1 4' bisphosphate C68H126N2O23P2", "notes": {"original_bigg_ids": ["lipidA_core_e_p"]}, "charge": 0, "formula": "C68H126N2O23P2", "compartment": "p", "id": "lipidA_core_e_p"}, {"name": "Phenylacetic acid", "notes": {"original_bigg_ids": ["pac_p"]}, "charge": 0, "formula": "C8H7O2", "compartment": "p", "id": "pac_p"}, {"name": "Core oligosaccharide lipid A C161H260N2O88P4", "notes": {"original_bigg_ids": ["colipaA_c"]}, "charge": 0, "formula": "C161H260N2O88P4", "compartment": "c", "id": "colipaA_c"}, {"name": "R1 galactosyl glucosyl glucosyl glucosyl inner core oligosaccharide lipid A C155H250N2O83P4", "notes": {"original_bigg_ids": ["gagggicolipaAR1_c"]}, "charge": 0, "formula": "C155H250N2O83P4", "compartment": "c", "id": "gagggicolipaAR1_c"}, {"name": "R1 glucosyl glucosyl glucosyl inner core oligosaccharide lipid A C149H240N2O78P4", "notes": {"original_bigg_ids": ["gggicolipaAR1_c"]}, "charge": 0, "formula": "C149H240N2O78P4", "compartment": "c", "id": "gggicolipaAR1_c"}, {"name": "Raffinose C18H32O16", "notes": {"original_bigg_ids": ["raffin_p"]}, "charge": 0, "formula": "C18H32O16", "compartment": "p", "id": "raffin_p"}, {"name": "D Arabinose C5H10O5", "notes": {"original_bigg_ids": ["arab_DASH_D_p"]}, "charge": 0, "formula": "C5H10O5", "compartment": "p", "id": "arab__D_p"}, {"name": "D Arabinose C5H10O5", "notes": {"original_bigg_ids": ["arab_DASH_D_c"]}, "charge": 0, "formula": "C5H10O5", "compartment": "c", "id": "arab__D_c"}, {"name": "D-Ribulose", "notes": {"original_bigg_ids": ["rbl_DASH_D_c"]}, "charge": 0, "formula": "C5H10O5", "compartment": "c", "id": "rbl__D_c"}, {"name": "D Arabinose C5H10O5", "notes": {"original_bigg_ids": ["arab_DASH_D_e"]}, "charge": 0, "formula": "C5H10O5", "compartment": "e", "id": "arab__D_e"}, {"notes": {"original_bigg_ids": ["cdigmp_c"]}, "compartment": "c", "name": "Cyclic diguanosine monophosphate", "charge": 0, "id": "cdigmp_c"}, {"notes": {"original_bigg_ids": ["dkfp_c"]}, "compartment": "c", "name": "6-deoxy-5-ketofructose 1-phosphate", "charge": 0, "id": "dkfp_c"}, {"name": "Phospho-heptosyl-phospho-heptosyl-heptosyl-kdo2-lipidA", "notes": {"original_bigg_ids": ["phphhlipa_c"]}, "charge": -10, "formula": "C131H230N2O63P4", "compartment": "c", "id": "phphhlipa_c"}, {"name": "Galactosyl-glucosyl-inner core oligosaccharide lipid A", "notes": {"original_bigg_ids": ["gagicolipa_c"]}, "charge": -11, "formula": "C157H271N2O84P4", "compartment": "c", "id": "gagicolipa_c"}, {"name": "Glucosyl-galactosyl-glucosyl-inner core oligosaccharide lipid A", "notes": {"original_bigg_ids": ["ggagicolipa_c"]}, "charge": -11, "formula": "C163H281N2O89P4", "compartment": "c", "id": "ggagicolipa_c"}, {"name": "2,3-dehydroadipyl-CoA", "notes": {"original_bigg_ids": ["23dhacoa_c"]}, "charge": -5, "formula": "C27H37N7O19P3S", "compartment": "c", "id": "23dhacoa_c"}, {"name": "(3S)-3-Hydroxyadipyl-CoA", "notes": {"original_bigg_ids": ["3hadpcoa_c"]}, "charge": -5, "formula": "C27H39N7O20P3S", "compartment": "c", "id": "3hadpcoa_c"}, {"notes": {"original_bigg_ids": ["srb1p_c"]}, "compartment": "c", "name": "Sorbose 1-phosphate", "charge": 0, "id": "srb1p_c"}, {"notes": {"original_bigg_ids": ["gggagicolipa_c"]}, "compartment": "c", "name": "Glucosyl-glucosyl-galactosyl-glucosyl-inner core oligosaccharide lipid A", "charge": 0, "id": "gggagicolipa_c"}, {"notes": {"original_bigg_ids": ["nicrns_c"]}, "compartment": "c", "name": "Nicotinate D-ribonucleoside", "charge": 0, "id": "nicrns_c"}, {"notes": {"original_bigg_ids": ["2ombz_c"]}, "compartment": "c", "name": "2-Octaprenyl-6-methoxy-1,4-benzoquinone", "charge": 0, "id": "2ombz_c"}, {"notes": {"original_bigg_ids": ["2ommb_c"]}, "compartment": "c", "name": "2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone", "charge": 0, "id": "2ommb_c"}, {"notes": {"original_bigg_ids": ["ah6p_DASH_D_c"]}, "compartment": "c", "name": "Arabino-3-hexulose-6-P", "charge": 0, "id": "ah6p__D_c"}, {"notes": {"original_bigg_ids": ["3hmp_c"]}, "compartment": "c", "name": "3-Hydroxy-2-methylpropanoate", "charge": 0, "id": "3hmp_c"}, {"notes": {"original_bigg_ids": ["3hibutcoa_c"]}, "compartment": "c", "name": "(S)-3-Hydroxyisobutyryl-CoA", "charge": 0, "id": "3hibutcoa_c"}, {"notes": {"original_bigg_ids": ["dhlam_c"]}, "compartment": "c", "name": "Dihydrolipoamide C8H17NOS2", "charge": 0, "id": "dhlam_c"}, {"notes": {"original_bigg_ids": ["lpam_c"]}, "compartment": "c", "name": "Lipoamide C8H15NOS2", "charge": 0, "id": "lpam_c"}, {"notes": {"original_bigg_ids": ["6pgg_c"]}, "compartment": "c", "name": "6pgg c", "charge": 0, "id": "6pgg_c"}], "version": 1, "id": "ic_1306"}