Alignment of several interesting Fz family members made by RN using the ClustalW program on DeCypher (July 15, 1999)

fz3/mouse       --------------------MAVSWIVFDLWLLTVFLG---QIGGHS--------LFSCE
fz4/mouse       ------MAWPGTGPS---SRGAPGGVGLRLGLLLQFLLLLRPTLGFGD-----EEERRCD
fz8/mouse       ---------MEWGYL-----LEVTSLLAALAVLQRSSG-AAAASAK---------ELACQ
fz5/human       ---------MARPDP-----SAPPSLL--LLLLAQLVG-RAAAASK---------APVCQ
fzd9/human      -----MAVAPLRGALLLWQLLAAGGAALEIGRFD-------PERGRG--------AAPCQ
fz1/rat         LEAPLLLGVRAQPAG---QVSG-PGQQRPPPPQPQQGG--QQYNGERG--ISIPDHGYCQ
fz2/rat         --------MRARSAL---PRSALPRLLLPLLLLPAAGP--AQFHGEKG--ISIPDHGFCQ
fz/Dros         ILPTLIQGVQRYDQS---PLDASPYYRSGGGLMASSG---TELDG-------LPHHNRCE
fz2/Dros/       GLVLLLTSCRADGPL-----HSADHGMGGMGMGGHGLD-ASPAPGYGVPAIPKDPNLRCE
                                                            .             *:
                 ________________________CRD_________________________________
fz3/mouse       PITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAPIC
fz4/mouse       PIRIAMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMC
fz8/mouse       EITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPIC
fz5/human       EITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCTMYTPIC
fzd9/human      AVEIPMCRGIGYNLTRMPNLLGHTSQGEAAAELAEFAPLVQYGCHSHLRFFLCSLYAPMC
fz1/rat         PISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVC
fz2/rat         PISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVC
fz/Dros         PITISICKNIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVC
fz2/Dros/       EITIPMCRGIGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPIC
                 : :  * .: **   :**  .*  *  *   :  : *:::  *    : :**:   *:*

               ________________CRD_________________
fz3/mouse       M-EYGRVTLPCRRLCQRAYSECSKLMEMFG-VPWPEDMECSRFPDCD-EPYPRLVDLN--
fz4/mouse       TEKINIPIGPCGGMCLSVKRRCEPVLREFG-FAWPDTLNCSKFPPQN-DHNHMCMEGP--
fz8/mouse       LEDYKKPLPPCRSVCERAKAGCAPLMRQYG-FAWPDRMRCDRLPEQG-NPDTLCMDYN-R
fz5/human       LPDYHKPLPPCRSVCERAKAGCSPLMRQYG-FAWPERMSCDRLPVLGRDAEVLCMDYN-R
fzd9/human      TDQVSTPIPACRPMCEQARLRCAPIMEQFN-FGWPDSLDCARLPTRN-DPHALCMEAPEN
fz1/rat         T-VLEQALPPCRSLCERA-QGCEALMNKFG-FQWPDTLKCEKFPVHG--AGELCVGQNTS
fz2/rat         T-VLEQAIPPCRSICERARQGCEALMNKFG-FQWPERLRCEHFPRHG--AEQICVGQNHS
fz/Dros         T-ILERPIPPCRSLCESA-RVCEKLMKTYN-FNWPENLECSKFPVHG--GEDLCVAENTT
fz2/Dros/       LEDYHKPLPVCRSVCERARSGCAPIMQQYS-FEWPERMACEHLPLHG-DPDNLCMEQPSY
                          *  :*  .   *           **. : *  :*          :


fz3/mouse       --------------------------------------------------LVGDPTE---
fz4/mouse       ---GDEE--------------------------------------------VPLPHKTP-
fz8/mouse       TDLTTAAPSPPRRLPPPPPPGEQPPSGSGHSRPPGARPPHRGGSSRGSGDAAAAPPSRGG
fz5/human       SEATTAPPRP---FPAKP---TLP--G-----PP--------------G----APAS-GG
fzd9/human      ATAGPAEPHK----GLGM----LP--------------------------VAPRPARPPG
fz1/rat         DKGTPTPSL-------------L--------------------------PEFWTSNPQHG
fz2/rat         EDG--TPAL-------------L--------------------------TTAPPSGLQPG
fz/Dros         SSA----------------------------------------------STAATPTRSVA
fz2/Dros/       TEAGSGGSSG----GSGG---SGSGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCR-GR
                                                                    .

                                                  _________TM1____________
fz3/mouse       YSFLHVRDCSPPCPN------MYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTR
fz4/mouse       --LNCVLKCGYDAG--------LYSRSAKEFTDIWMAVWASLCFISTTFTVLTFLIDSSR
fz8/mouse       -KTGQIANCALPCHN------PFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMER
fz5/human       -RTGQVPNCAVPCYQ------PSFSADERTFATFWIGLWSVLCFISTSTTVATFLIDMDT
fzd9/human      --RSCAPRCGPGVEV-------FWSRRDKDFALVWMAVWSALCFFSTAFTVLTFLLEPHR
fz1/rat         LGEK---DCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRR
fz2/rat         LGER---DCAAPCEPARPDGSMFFSHHHTRFARLWILTWSVLCCASTFFTVTTSLVAMQR
fz/Dros         VGGKDLHDCGAPCH------AMFFPERERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSR
fz2/Dros/       QRIAGVPNCGIPCKG------PFFSNDEKDFAGLWIALWSGLCFCSTLMTLTTFIIDTER
                        *                          :   : :*      :. *
                          ____________TM2______
fz3/mouse       FRYPERPIIFYAVCYMMVSLIFFIGFLLE-DRVACNASSP--------------------
fz4/mouse       FSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDF-----------------------
fz8/mouse       FKYPERPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGRGGAGGAAAAGAGAAG
fz5/human       FRYPERPIIFLSACYLCVSLGFLVRLVVGHASVACS------------------------
fzd9/human      FQYPERPIIFLSMCYNVYSLAFLIRAVAGAQSVACD------------------------
fz1/rat         FSYPERPIIFLSGCYTAVAVAYIAGFLLE-DRVVCNDKFAE-------------------
fz2/rat         FRYPERPIIFLSGCYTMVSVAYIAGFVLQ-ERVVCNERFSE-------------------
fz/Dros         FRYPERAIVFLAVCYLVVGCAYVAGLGAG-DSVSCREPFPPPVK---LG-----------
fz2/Dros/       FKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACDG-----------------------
                * ****.::* . **   .  :.
                                                     ____________TM3_________
fz3/mouse       --------------AQYKASTVTQGSHNK-ACTMLFMVLYFFTMAGSVWWVILTITWFLA
fz4/mouse       --------------EEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLA
fz8/mouse       RGASSPGARGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLA
fz5/human       R----------------EHNHIHYETTGPALCTIVFLLVYFFGMASSIWWVILSLTWFLA
fzd9/human      --------------QEAGALYVIQEGLENTGCTLVFLLLYYFGMASSLWWVVLTLTWFLA
fz1/rat         ----------------DGARTVAQGTKKE-GCTILFMMLYFFSMASSIWWVILSLTWFLA
fz2/rat         ----------------DGYRTVGQGTKKE-GCTILFMMLYFFSMASSIWWVILSLTWFLA
fz/Dros         --------------RLQMMSTITQGHRQTTSCTVLFMALYFCCMAAFAWWSCLAFAWFLA
fz2/Dros/       -------------------LLLRESSTGPHSCTLVFLLTYFFGMASSIWWVILTFTWFLA
                                     :         *   ::   :  :..  **  ::: ::*:
                                  ____________TM4____
fz3/mouse       AVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYF
fz4/mouse       AGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGF
fz8/mouse       AGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGF
fz5/human       AAMKWGNEAIAGYGQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRRF
fzd9/human      AGKKWGHEAIEAHGSYFHMAAWGLPALKTIVILTLRKVAGDELTGLCYVASTDAAALTGF
fz1/rat         AGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGF
fz2/rat         AGMKWGHAAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNRLDPLRGF
fz/Dros         AGLKWGHEAIENKSHLFHLVAWAVPALQTISVLALAKVEGDILSGVCFVGQLDTHSLGAF
fz2/Dros/       AGLKWGNEAITKHSQYFHLAAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTF
                :  **.  *:   .  **  **  *   .:  * :  :  . : *:*:.          *
                  ______________TM5______                             _______
fz3/mouse       VLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKE-----NQDKLVKFMIRIGVFSILYL
fz4/mouse       VVAPLFTYLVIGTLFIAAGLVALFKIRSNLQK-DG----TKTDKLERLMVKIGVFSVLYT
fz8/mouse       VLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQGGP---TKTHKLEKLMIRLGLFTVLYT
fz5/human       VLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQ-GG----TKTDKLEKLMIRIGIFTLLYT
fzd9/human      VLVPLSGYLVLGSSFLLTGFVALFHIRKIMKT-GG----TNTEKLEKLMVKIGVFSILYT
fz1/rat         VLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKH-DG----TKTEKLEKLMVRIGVFSVLYT
fz2/rat         VLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKH-DG----TKTEPLERLMVRIGVFSVLYT
fz/Dros         LILPLCIYLSIGALFLLAGFISLFRIRTVMKT-DG----KRTDKLERLMLRIGFFSGLFI
fz2/Dros/       VLAPLFVYLVIGTTFLMAGFVSLFRIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYT
                :  *    : :*  :   .  :*  ::  :            . : ::  :: .*: *:
                  ___TM6______                                       ________
fz3/mouse       VPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQMS-------RPDLILFLM
fz4/mouse       VPATCVIACYFYEISNWALFRYSADDS--------------------------NMAVEML
fz8/mouse       VPAAVVVACLFYEQHNRPRWEATHNCPCLRDLQPDQARR-------------PDYAVFML
fz5/human       VPASIVVACYLYEQHYRESWEAALTCACPGHDTGQPRAK-------------PEYWVLML
fzd9/human      VPATCVIVCYVYERLNMDFWRLRATEQPCAAAAGPGGRRDCSLP----GGSVPTVAVFML
fz1/rat         VPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQGGGGVPPHPPMSPDFTVFMI
fz2/rat         VPATIVIACYFYEQAFREHWERSWVSQHCKSLAIPCPAHYT-------PRTSPDFTVYMI
fz/Dros         LPAVGLLGCLFYEYYNFDEWMIQWHRDICKPFSIPCPAARAPGS----PEARPIFQIFMV
fz2/Dros/       VPATIVIGCYLYEAAYFEDWIKALACPCAQVK--GPGKK-------------PLYSVLML
                 *    : . . *                                             ::
                  _______TM7______
fz3/mouse       KYLMALIVGIPSIFWVGSKKTCFEWASFFHGRRKKEIVNESRQVLQEPDFAQSLLRDPNT
fz4/mouse       KIFMSLLVGITSGMWIWSAKTLHTWQKCS-----------NRLVNSGKVK-----REKRG
fz8/mouse       KYFMCLVVGITSGVWVWSGKTLESWRALC-----------TRCCWASKGAAVGAGAGGSG
fz5/human       KYFMCLVVGITSGVWIWSGKTVESWRRFT-----------SRCCCRPR-------RGHK-
fzd9/human      KIFMSLVVGITSGVWVWSSKTFQTWQSLC-----------YRKIAAGRARA----KACRA
fz1/rat         KYLMTLIVGITSGFWIWSGKTLNSWRKFY-----------TRLTNSK--------QGETT
fz2/rat         KYLMTLIVGITSGFWIWSGKTLHSWRKFY-----------TRLTNSR--------HGETT
fz/Dros         KYLCSMLVGVTSSVWLYSSKTMVSWRNFV-----------ERLQGKEPRT-----RAQAY
fz2/Dros/       KYFMALAVGITSGVWIWSGKTLESWRRFW-----------RRLLGAPDRTGANQALIKQR
                : :  :  *  : .*: * **   :