The following table “ Wnt signaling in different developmental processes in the worm and the players involved” has been assembled by David Eisenmann (Latest update June 2002, send comments/corrections here). Thanks to David for this contribution.

Note that whereas some of these developmental processes, such as P2>EMS signaling are somewhat different from the more familiar Wnt signaling events, other Wnt signaling pathways in C. elegans, such as the postembryonic Q migration are “canonical” in the sense that they use the same components as vertebrate/Drosophila pathways.

Protein/gene	P2-> EMS E fate	P2->EMS spindle rot.	VPC fate	Q progeny migration.	P12 fate	T cell polarity	P7.p polarity	V cells	gonad migration
Porcupine	MOM-1 5, 6	MOM-1 20	MOM-1 3
Wnt	MOM-2 5, 6			EGL-20 9	LIN-44 1	LIN-44 24, 25		EGL-20 23
Frizzled	MOM-5 5, 6	MOM-5 20		LIN-17 MIG-1 9, 27	LIN-17 1	LIN-17 14, 15	LIN-17 14, 15	LIN-17 23
Disheveled			MIG-5 26	MIG-5 26	MIG-5 26
GSK3	GSK-3 20	GSK-3 20
Axin**			PRY-1 3	PRY-1 8	PRY-1 3			PRY-1 8, 23
APC	APR-1 5		APR-1 11			no? 31
b-catenin	WRM-1 5		BAR-1 4	BAR-1 8	BAR-1 2	no 28		BAR-1 23	WRM-1? 3
TCF	POP-1 7			POP-1 28, 29		POP-1 28			POP-1 3
target gene			lin-39 4	mab-5 10	egl-5 1			mab-5 23
LIT-1 (NLK)	yes 12, 13, 16		no 3			yes 13
MOM-4 (TAK)	yes 6, 16, 17					no 31
MIG-14 (?) (pka MOM-3)	yes 6	yes 20	yes 2	yes 9	yes 2	no 30, 31	yes 21		yes 2, 19

|------ embryonic ----------||------------------------ postembryonic ------------------------------------------------------|

** pry-1 encodes an Axin homolog

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