History of these pages

December 18, 2009

• new page on the history of the Wnt meeting
• new meetings
• new page on Wntless
• new table on small molecules
• new page on gene expression sites
• Signaling pathway diagram simplified, for clarity
• Mouse Wnt2/2b phenotype in lung development
• Mouse Wnt9b phenotype in kidney development
• Frizzled-4 phenotype in vasculature CNS and retina
• Frizzled-3,6 phenotype in midbrain
• Novel mouse GSK3 phenotype in neural development
• New target genes, NeuroD, Gbx2, Sox17
• Human WTX mutations in skeletal dysplasia
• TNIK and KLF4 interact with beta-catenin

June 2, 2009

• Google search window for the Wnt homepage added
• Axin interacts with myc
• Sirtuin1 interacts with beta-catenin
• Various Mouse Wnt5a phenotypes
• New small molecules
• new target genes, Jagged, Wnt3a

December 16, 2008

• Mouse Wnt3a phenotype in HSC self-renewal
• Mouse Wnt7b phenotype in the Kidney and vasculature CNS
• Mouse Wnt7a phenotype in the vasculature CNS
• Frizzled-5 phenotype in ocular development
• Dishevelled3 phenotype in cardiac outflow tract
• Mouse LRP5 implicated Bone formation (through serotonin synthesis)
• CDK8, AGGF1 and VHL interact with beta-catenin
• IGFBP binds to Frizzled
• new target genes, N-myc, snail

September 1, 2008

• Human Wnt10B mutations in Split-Hand/Foot Malformation
• Human Wnt4 mutations in SERKAL syndrome
• Mouse Wnt7B phenotype in the lung
• new target genes, Oct4, CTLA-4
• More micro-array expression profiling of Wnt targets
• Page on Evolutionary conservation of Wnt signaling updated; Wnts in Trichoplax (placozoans) and Wnt signaling during regeneration of Planaria.
• Frizzled-5 phenotype in neuronal survival in the parafascicular nucleus
• b-catenin phenotypes in adrenal cortex

January 3, 2008

• Human Wnt10A mutations in Odonto-onycho-dermal dysplasia
• Drosophila Wnt4 phenotype in synaptic target specificity
• C. elegans Wnt phenotypes
• Fhit and Nek2 bind to beta-catenin
• Smad3 binds to Axin
• Mutant forms of LRP5 implicated in human Hyperparathyroidism
• Mouse Wnt5a phenotype in mammary gland development
• SFRP2 phenotype
• new target genes, NKX2.2, LGR5/GPR49, P16ink4A, Gremlin

August 1, 2007: 10 years of the Wnt homepage!

• new page on alternative Wnt receptors
• Human LRP6 implicated in heart disease and Alzheimer
• Human Porcupine in Focal dermal hypoplasia
• Human WNT7a in Fuhrmann syndrome
• Human VANGL1 in neural tube defects
• Human RSPO4 in autosomal recessive anonychia
• Human WTX in Wilms tumor
• New pathway component, WTX
• Mouse Wnt5a and Nkd phenotypes
• Novel mouse GSK3 phenotypes
• Wnt signaling in regeneration Zebrafish
• New small molecules, IQ1 and QS11
• New mouse Wnt reporter
• more reviews
• new target genes, Islet1, MMPs, Cdx1

November 20, 2006

• Update on meetings 2007!
• Page on Evolutionary conservation of Wnt signaling updated; Wnts in sponges
• target genes nanog, SALL4, Jagged1
• Human AXIN1 phenotype
• Lrp6 mouse phenotype
• more reviews

July 26, 2006

• New pathway components (Hyrax, Wls/Evi, Retromer, MACF1)
• Wnt9a phenotype in the mouse
• Wnt2b phenotype in Zebrafish
• more reviews
• New small molecule
• new target gene, iNOS

April 20, 2006

• 2 new meetings for 2007!
• C. elegans Wnt signaling linked to Wormbook
• C. elegans Wnt and Frizzled phenotypes in neuron migration
• Frizzled8 activated by R-spondin
• Frizzled4 activated by Wnt5A and LRP5
• WNT10B mutations in human obesity (see diseases as well)
• LEF1 mutations in human sebaceous tumors
• TCF4 associated with type II diabetes in humans (see diseases as well)
• Page on SFRP updated, new Sizzled function, Sfrp1 and Sfrp2 phenotypes
• Various new regulators (KLHL12-Cullin-3 ubiquitin ligase; PR130; the MED12 subunit in Mediator
• KLHL12 binds to Dsh
• Mouse Dvl1/Dvl2 phenotype in convergent extension
• target genes RANK ligand, FGF9, CCN1/Cyr61, Runx2, new profiling data
• more reviews
• Zebrafish Wnt genes uppdated, linked to ZFIN
• Dickkopf3 phenotype in mouse and a Dickkopf gene in Hydra
• LRP6 can mediate internalization and lethality of Anthrax Toxin

January 3, 2006

• New page on micro-array expression profiling of Wnt targets
• new reviews
• New pathway component (CK1gamma, Hint1)
• b-catenin phenotypes in pancreas, chondrogenesis
• Lgl binds to Dishevelled interactions
• Wnt3A phenotype in left-right asymmetry Mouse
• Wnt3 involved in medial-lateral retinotectal topography Mouse
• Wnt3 in hippocampal neurogenesis Mouse
• Wnt7B phenotype in vasculature Mouse
• Wnt9B phenotype in Mouse kidney development
• Wnt11 in Zebrafish gastrulation by controlling cell cohesion through Rab5c and E-cadherin
• Mouse Dickkopf-2 phenotype in bone
• SFRP1 regulates growth of retinal ganglion cell axons
• Drosophila Wnt4 phenotype in retinal projections
• Drosophila WntD phenotype in innate immunity
• Frizzled-4 phenotype Impaired Corpora Lutea Formation
• New target genes , Cdx4, interleukin8, Tiam
• New small molecule inhibitor of Dsh

July 13, 2005

• Page on Evolutionary conservation of Wnt signaling updated; Wnt family in the Nematostella
• Axin updated, functional equivalence Axin/Axin2 and Axin 2 KO phenotype
• Page on Frat updated, triple KO in mice.
• Dishevelled page updated.
• Mouse Wnt10B phenotype
• Mouse Frizzled 5 and 9 phenotypes
• Xenopus Wnt11 phenotype in axis
• More small molecules
• Several new pathway components (PR72, G, Shisa)
• New target genes (FGF20, L1. EGFR) and several microarray studies
• Binding FOXO to b-catenin: interactions
• TCF4-Jun binding in pathway and interactions
• Epigenetic loss SFRP in Wnt-Cancer
• Several reviews added
• Page on meetings updated, link to Keystone Wnt/ß-catenin meeting in 2006

December 1, 2004

• New page on how to activate Wnt signaling in cells
• LRP phenotypes (dorsal thalamus, bone) in mouse. Spontaneous LRP mutant in mice.
• Dkk, SOX9, PTTG, Delta-like and others in target genes
• Dkk added to table of feedback targets
• Bcl9/legless role in beta-catenin transport to the nucleus
• WNT5B associated with human diabetes, see also Disease Table
• Derailed/RYK, RYK-Dsh interactions added to pathway and interactions.
• CtBP binding to APC in pathway
• 14-3-3 binding to beta-catenin interactions
• Mouse Naked 1 mutant
• Tissue specific APC knockouts in mice
• b-catenin phenotype in joints
• Several reviews added
• Page on meetings updated, link to Aberdeen Wnt meeting.

September 14, 2004

• Several reviews added
• ß-catenin phenotypes added
• Dapper-Frodo relationship clarified in pathway and interactions.
• Human WNT4 mutation in Mullerian-duct regression, see also Table
• small molecules to manipulate Wnt signaling updated
• Links to MGI updated
• Maternal b-catenin mouse phenotype
• PSD95 and Magi3 added as Fz binding proteins in interactions

June 28, 2004

• New table: Feedback targets: Wnt signaling components that are regulated by the signal
• LRP phenotypes (Human FEVR) and mouse double LRP 5,6
• Norrin added to pathway, interactions and Human Disease Table
• Axin mutations in Table, human tooth agenesis
• Par5/14-3-3 added to pathway
• Wnt5A as tumor suppressor on Wnt in cancer diagram
• 2 Cell stage pathway figure updated
• Mouse Frizzled 6 phenotype
• Dkk2-Kremen2 interaction added
• Mouse TCF1,4 double mutant phenotype
• Several reviews added
• ß-catenin phenotypes added
• Mouse Wnt5A and Wnt7A phenotypes
• FGF18, neurogenin, nemo and others in target genes

March 11, 2004

• Page on TCF updated, TCF 3 KO. All 4 TCF genes in the mouse are now knocked-out.
• review added , Convergence of Wnt, b-catenin, and Cadherin Pathways
• Page on Wnt in primitive organisms updated; Wnt in the planarian Girardia tigrina
• Page added on small molecules to manipulate Wnt signaling
• Human WNT3 mutation in Tetra-amelia
• Mouse and Zebrafish SFRP mutant phenotypes added
• Table added on human diseases and Wnt signaling

December 22, 2003

• New page on reagents
• Wnt 4 (anterior-posterior guidance commissural axons) and Wnt5a (in lympoid tumors) phenotypes in the mouse
• Mouse Frizzled 3 mutant phenotype (commissural axons)
• Page on Wnt in primitive organisms updated; b-catenin in Nematostella, Fz in sponges.
• Meetings updated, Keystone meetings
• Several reviews added

October 14, 2003

• New page on Wnt reporters in animals
• Several reviews added
• Chibby, Dsh-Fz, Eph, PKC added to interactions
• Links to PubMed updated, renewed
• Page on TCF updated, nomenclature
• Wise and LKB1 (XEEK1) added to pathway
• Many genes added to target genes
• Zebrafish APC mutant
• Zebrafish Wnt11 mutant phenotype (hypoblast migration)
• Fz4-Wnt5A interaction added

September 4, 2003

• Wnt4 phenotype in the gonad of the mouse
• Several reviews added
• Meetings updated, 2004 Wnt meeting

July, 1 2003

• Wnt11 loss of function phenotype in the mouse
• E-Cadherin, Twist, stromelysin added to target genes
• Chibby, Disabled-2 added to pathway
• review added: Stem cells in the skin: waste not, Wnt not.Genes Dev. 2003
• Note on availibity antiserum to mouse Wnt3a on antibody page and Wnt protein page
• Meetings updated

April 20, 2003

• New Wnt protein page and purification methods
• Wnt3A phenotype in Mouse segmentation clock
• Wnt9A/B renamed (from Wnt14/15) in mouse, human vertebrate tables
• Syntenic linkage table updated, includes Drosophila Wnt genes
• Drosophila Wnt5 phenotype in axon guidance
• Zebrafish Wnt1/10B phenotype

March 3, 2003

• Boca/mesd added to pathway
• Wnt3 phenotype in Mouse AER, Wnt5A in Mouse chondrocytes
• Osteocalcin/Proglucagon added to target genes
• Several reviews added
• Page on Porcupine updated, new links
• More structural information on GSK and Frat.

January 3, 2003

• Links to Human and Mouse Wnt genes updated with links to MGI, GeneCards
• Interpro links added to many proteins
• Page on Dishevelled updated with phenotypes and new links to MGI, GeneCards
• Eda, Ephrin, Pitx2, MBP4, VEGF, FGF4 added to target genes
• Pitx2-b-catenin interaction added to pathway
• Mouse LRP5 phenotype added
• New reviews added
• Wnt-2b phenotype in mouse Wnt genes
• Gordon conferences added to meetings

October 11, 2002

• New Figure Wnt-Hedgehog comparison
• Page on LRP unpdated, new mouse and human phenotypes
• Interactions Drosophila Frizzleds and Wnts added
• Gastrin and Nr-CAM added to target genes
• Frizzled 3 phenotype in mouse
• Wnt-7B phenotype in the Mouse lung
• I-mfa added to protein-protein interactions
• Juan March meeting added

August 15, 2002

• Diversin added to pathway and protein-protein interactions
• New Target genes, complete data set microarray experiment
• Wnt-11 function in Xenopus
• Dishevelled mutants in Drosophila
• Human Frizzled 4 mutant phenotype
• Mouse Wnt5A lung phenotype

June 13, 2002

• New page on how to inhibit Wnt signaling
• Several new Target genes
• Drosophila Wnt-4 phenotype added
• New players in page on protein-protein interactions
• New players (Kremen, Dapper, Frodo) in pathway
• Pry1 (Axin) added to C. elegans table

April 10, 2002

Major update, new lay out.

• Entirely new page on protein-protein interactions
• Page on APC
• Expanded page on b-catenin
• Page on porcupine
• Page on GSK, with structure
• Page on GBP/Frat
• Mouse Wnt-1; Wnt-4 phenotype. Cloning Mouse Wnt-14
• Legless, Pygopus, CK1alpha, PP2A in pathway
• Lgs/Bcl9 added to Wnt in cancer diagram
• Page on Wnt protein production updated
• Human LRP5 phenotype
• Frizzled structure, phenotypes
• Drosophila Wnt-2 phenotype
• Several new Target genes
• Dickkopf mouse phenotype
• More reviews

Sept 10, 2001

• HBP1 and Brg-1 added to pathway
• Wnt-7B phenotype added to mouse genes

August 1, 2001

• Page added on LRP/Arrow
• Page added on Naked
• Page added on Dickkopf
• New Frizzled and smoothened mouse KO phenotypes
• Axin mutation in Zebrafish
• Stra6 and Wrch1 added to target genes
• Par1 added to pathway
• Table syntenic linkage groups of Wnt genes added
• Several new reviews added
• Zebrafish Wnt-8 phenotype added

June 22, 2001

• Table C. elegans Wnt signaling added