Graduate courses in Chemical Engineering

(Same as CHEMENG 140.) Microelectronics processing technologies in industrial sectors such as semiconductor, biotechnology, and energy. The chemistry and transport of microelectronics device fabrication. Solid state materials and electronic devices and chemical processes including crystal growth, chemical vapor deposition, etching, oxidation, doping, diffusion, metallization, plasma processing. Micropatterning involving photolithography and nanopatterning using unconventional soft lithography and self assembly. Recommended: CHEM 33, 171, and PHYSICS 55.

3 units, Spr (Bao, Z)

CHEMENG 260. Polymer Science and Engineering

(Same as CHEMENG 160.) Interrelationships among molecular structure, morphology, and mechanical behavior of polymers. Topics include amorphous and semicrystalline polymers, glass transitions, rubber elasticity, linear viscoelasticity, and rheology. Applications of polymers in biomedical devices and microelectronics. Recommended: CHEM 33 and 171, or equivalent.

3 units, Win (Hwang, L)

CHEMENG 274. Environmental Microbiology I

(Same as CHEMENG 174, CEE 274A.) Basics of microbiology and biochemistry. The biochemical and biophysical principles of biochemical reactions, energetics, and mechanisms of energy conservation. Diversity of microbial catabolism, flow of organic matter in nature: the carbon cycle, and biogeochemical cycles. Bacterial physiology, phylogeny, and the ecology of microbes in soil and marine sediments, bacterial adhesion, and biofilm formation. Microbes in the degradation of pollutants. Prerequisites: CHEM 33, 35, and BIOSCI 41, CHEMENG 181 (formerly 188), or equivalents.

3 units, Aut (Krieger, C), Sum (Staff)

CHEMENG 281. Biochemistry I

(Same as BIO 188, BIO 288, CHEMENG 181, CHEM 181.) (CHEMENG offerings formerly listed as 188/288.) Chemistry of major families of biomolecules including proteins, nucleic acids, carbohydrates, lipids, and cofactors. Structural and mechanistic analysis of properties of proteins including molecular recognition, catalysis, signal transduction, membrane transport, and harvesting of energy from light. Molecular evolution. Prerequisites: CHEM 135 or 171.

3 units, Win (Zare, R; Altman, D)

CHEMENG 283. Biochemistry II

(Same as BIO 189, BIO 289, CHEMENG 183, CHEM 183.) (CHEMENG offerings formerly listed as 189/289.) Metabolism. Glycolysis, gluconeogenesis, citric acid cycle, oxidative phosphorylation, pentose phosphate pathway, glycogen metabolism, fatty acid metabolism, protein degradation and amino acid catabolism, protein translation and amino acid biosynthesis, nucleotide biosynthesis, DNA replication, recombination and repair, lipid and steroid biosynthesis. Medical consequences of impaired metabolism. Therapeutic intervention of metabolism. Prerequisite: BIO 188/288 or CHEM 181 or CHEMENG 181/281 (formerly 188/288).

3 units, Spr (Dunn, A)

CHEMENG 300. Applied Mathematics in the Chemical and Biological Sciences

(Same as CME 330.) Mathematical solution methods via applied problems including chemical reaction sequences, mass and heat transfer in chemical reactors, quantum mechanics, fluid mechanics of reacting systems, and chromatography. Topics include generalized vector space theory, linear operator theory with eigenvalue methods, phase plane methods, perturbation theory (regular and singular), solution of parabolic and elliptic partial differential equations, and transform methods (Laplace and Fourier). Prerequisites: CME 102/ENGR 155A and CME 104/ENGR 155B, or equivalents.

3 units, Aut (Shaqfeh, E)

CHEMENG 310. Microscale Transport in Chemical Engineering

Transport phenomena on small-length scales appropriate to applications in microfluidics, complex fluids, and biology. The basic equations of mass, momentum, and energy, derived for incompressible fluids and simplified to the slow-flow limit. Topics: solution techniques utilizing expansions of harmonic and Green's functions; singularity solutions; flows involving rigid particles and fluid droplets; applications to suspensions; lubrication theory for flows in confined geometries; slender body theory; and capillarity and wetting. Prerequisites: 120A,B, 300, or equivalents.

3 units, Win (Fuller, G)

CHEMENG 340. Molecular Thermodynamics

Classical thermodynamics and quantum mechanics. Development of statistical thermodynamics to address the collective behavior of molecules. Establishment of theories for gas, liquid, and solid phases, including phase transitions and critical behavior. Applications include electrolytes, ion channels, surface adsorption, ligand binding to proteins, hydrogen bonding in water, hydrophobicity, polymers, and proteins.

3 units, Aut (Spakowitz, A)

CHEMENG 345. Fundamentals and Applications of Spectroscopy

Development of theoretical approaches to spectroscopy, including spectroscopic transitions, transition probabilities, and selection rules. Application to photon and electron spectroscopies of the gas and solid phases. Topics: rotational spectroscopy; infrared and Raman vibrational spectroscopies; fluorescence spectroscopy; Auger, x-ray and ultraviolet photoelectron spectroscopies. Prerequisite: CHEM 271 or course in quantum mechanics.

3 units, Win (Jaramillo, T)

CHEMENG 355. Advanced Biochemical Engineering

(Same as BIOE 355.) Combines biological knowledge and methods with quantitative engineering principles. Quantitative review of biochemistry and metabolism; recombinant DNA technology and synthetic biology (metabolic engineering). The production of protein pharaceuticals as a paradigm for the application of chemical engineering principles to advanced process development within the framework of current business and regulatory requirements. Prerequisite: CHEMENG 181 (formerly 188) or BIOSCI 41, or equivalent.

3 units, Spr (Swartz, J)

CHEMENG 442. Structure and Reactivity of Solid Surfaces

The structure of solid surfaces including experimental methods for determining the structure of single crystal surfaces. The adsorption of molecules on these surfaces including the thermodynamics of adsorption processes, surface diffusion, and surface reactions. Molecular structure of adsorbates. Current topics in surface structure and reactivity, including systems for heterogeneous catalysis and electronic materials.

3 units, not given this year

CHEMENG 450. Advances in Biotechnology

Guest academic and industrial speakers. Latest developments in fields such as bioenergy, green process technology, production of industrial chemicals from renewable resources, protein pharmaceutical production, industrial enzyme production, stem cell applications, medical diagnostics, and medical imaging. Biotechnology ethics, business and patenting issues, and entrepreneurship in biotechnology.

3 units, not given this year

CHEMENG 454. Synthetic Biology and Metabolic Engineering

(Same as BIOE 454.) Principles for the design and optimization of new biological systems. Development of new enzymes, metabolic pathways, other metabolic systems, and communication systems among organisms. Example applications include the production of central metabolites, amino acids, pharmaceutical proteins, and isoprenoids. Economic challenges and quantitative assessment of metabolic performance. Pre- or corequisite: CHEMENG 355 or equivalent.

3 units, alternate years, not given this year

CHEMENG 456. Metabolic Biochemistry of Microorganisms

(Same as CEE 274B.) Microbial metabolism, biochemical and metabolic principles, unity and diversity of metabolic pathways, evolution of enzymes and metabolic pathways, microbial degradation of natural and anthropogenic organic compounds, predicting biodegradation, and metabolic origin of life.

3 units, Win (Spormann, A), alternate years, not given next year

CHEMENG 457. Microbial Ecology and Evolution

(Same as CEE 274C.) Structure/function relationship of microbial communities; metabolic and ecological basis of interactions in microbial communities; microbial ecology and population biology in natural and human host systems; and evolution of microbial life. Prerequisite: CEE 274A, CHEMENG 281 (formerly 288), or equivalent.

3 units, not given this year

CHEMENG 458. Recent Advances in Genetic, Cellular, and Biomolecular Systems

Current topics, experimental methods, technologies, quantitative analysis, and mathematical models.

3 units, Aut (Wang, C)

CHEMENG 459. Frontiers in Interdisciplinary Biosciences

(Same as BIO 459, BIOC 459, BIOE 459, CHEM 459, PSYCH 459.) Students register through their affiliated department; otherwise register for CHEMENG 459. For specialists and non-specialists. Sponsored by the Stanford BioX Program. Three seminars per quarter address scientific and technical themes related to interdisciplinary approaches in bioengineering, medicine, and the chemical, physical, and biological sciences. Leading investigators from Stanford and the world present breakthroughs and endeavors that cut across core disciplines. Pre-seminars introduce basic concepts and background for non-experts. Registered students attend all pre-seminars; others welcome. See http://biox.stanford.edu/courses/459.html. Recommended: basic mathematics, biology, chemistry, and physics.

1 unit, Aut (Robertson, C), Win (Robertson, C), Spr (Robertson, C)

CHEMENG 460. Polymer Surfaces and Interfaces

Principles of interfacial thermodynamics and polymer physics applied to polymer surfaces and interfaces. Treatments of intermolecular forces; conformational statistics of macromolecular structure; models for polymer dynamics; tethering of polymers at different interfaces; techniques for chemical modification of surfaces; methods for physical characterization of polymer surfaces and interfaces. Applications in adhesion and biocompatibility. Prerequisite: exposure to principles of polymer science or consent of instructor.

3 units, alternate years, not given this year

CHEMENG 461. Polymeric Materials in Medical Devices

Integrated approach to polymer synthesis, characterization, and processing for polymer properties of technological benefit in biomedical devices. Classes of materials include ultra high molecular weight polyethylene, silicone elastomers, block copolymer segmented polyurethanes, highly orientated nylon fibers, hydrogels, and biodegradable polymers. Applications include prosthetic orthopedic devices, ophthalmic devices, sutures, and drug delivery systems.

3 units, not given this year

CHEMENG 462. Complex Fluids and Non-Newtonian Flows

Division of complex fluids into suspensions, solutions, and melts. Suspensions as colloidal and non-colloidal. Extra stress and relation to the stresslet. Suspension rheology including Brownian and non-Brownian fibers. Microhydrodynamics and the Fokker-Planck equation. Linear viscoelasticity and the weak flow limit. Polymer solutions including single mode (dumbbell) and multimode models. Nonlinear viscoelasticity. Intermolecular effects in nondilute solutions and melts and the concept of reptation. Prerequisites: low Reynolds number hydrodynamics or consent of instructor.

3 units, Win (Shaqfeh, E)

CHEMENG 464. Polymer Chemistry

Polymer material design, synthesis, characterization, and application. Topics include organic and kinetic aspects of polymerization, polymer characterization techniques, and structure and properties of bulk polymers for commercial applications and emerging technologies.

3 units, alternate years, not given this year

CHEMENG 466. Polymer Physics

Concepts and applications in the equilibrium and dynamic behavior of complex fluids. Topics include solution thermodynamics, scaling concepts, semiflexibility, characterization of polymer size (light scattering, osmotic pressure, size-exclusion chromatography, intrinsic viscosity), viscoelasticity, rheological measurements, polyelectrolytes, liquid crystals, biopolymers, and gels.

3 units, Win (Spakowitz, A), alternate years, not given next year

CHEMENG 500. Special Topics in Protein Biotechnology