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This archived information is dated to the 2008-09 academic year only and may no longer be current.
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Stanford Bulletin, Archive 2008-09
Stanford Bulletin, Archive 2008-09
Graduate courses in Structural Biology
Primarily for graduate students; undergraduates may enroll with consent of instructor.
SBIO 228. Computational Structural Biology
(Same as BIOPHYS 228.) Interatomic forces and interactions such as electrostatics and hydrophobicity, and protein structure in terms of amino acid properties, local chain conformation, secondary structure, domains, and families of folds. How protein motion can be simulated. Bioinformatics introduced in terms of methods that compare proteins via their amino acid sequences and their three-dimensional structures. Structure prediction via simple comparative modeling. How to detect and model remote homologues. Predicting the structure of a protein from knowledge of its amino acid sequence. Via Internet.
3 units, Aut (Levitt, M), Spr (Levitt, M)
SBIO 229. The Eukaryote Chromosome
The principles of chromosome structure and function including the structure, dynamics, and topological forms of DNA; units and hierarchies of DNA coiling in chromosomes; centromeres, telomeres, and basis of chromosome maintenance and sorting in mitosis; mechanism of gene activation with particular regard to enhancer, promoter, and terminator sequences; basis of sequence-specific protein-DNA interaction; and organization and assembly of the cell nucleus. Prerequisite: knowledge of basic biochemistry and cell biology.
3 units, not given this year
SBIO 241. Biological Macromolecules
(Same as BIOC 241, BIOPHYS 241.) The physical and chemical basis of macromolecular function. Forces that stabilize biopolymers with three-dimensional structures and their functional implications. Thermodynamics, molecular forces, and kinetics of enzymatic and diffusional processes, and relationship to their practical application in experimental design and interpretation. Biological function and the level of individual molecular interactions and at the level of complex processes. Case studies. Prerequisites: introductory biochemistry and physical chemistry or consent of instructor.
3-5 units, Aut (Herschlag, D; Puglisi, J; Garcia, K; Ferrell, J; Block, S; Weis, W)
SBIO 242. Methods in Molecular Biophysics
(Same as BIOPHYS 242.) Experimental methods in molecular biophysics from theoretical and practical standpoints. Emphasis is on X-ray diffraction, nuclear magnetic resonance, and fluorescence spectcroscopy. Prerequisite: physical chemistry or consent of instructor.
3 units, Win (Weis, W; Puglisi, J), alternate years, not given next year
SBIO 274. Topics in Nucleic Acid Structure and Function
Principles of nucleic acid structure and function. Methods for investigating nucleic acid structure. Limited to graduate students and postdoctoral fellows in structural biology. Prerequisite: consent of instructor.
2 units, not given this year
SBIO 299. Directed Reading in Structural Biology
Prerequisite: consent of instructor.
1-18 units, Aut (Staff), Win (Staff), Spr (Staff), Sum (Staff)
SBIO 399. Graduate Research
Students undertake investigations sponsored by individual faculty members. Prerequisite: consent of instructor.
1-18 units, Aut (Staff), Win (Staff), Spr (Staff), Sum (Staff)
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